{ "directed": true, "multigraph": false, "graph": {}, "nodes": [ { "id": "reaction_10584068", "map_id": "none", "name": "Transcriptional activation of FAS monomer gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10594322", "map_id": "none", "name": "p-Y701-STAT1-1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O00910", "map_id": "O00910", "name": "dstA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281381", "map_id": "DDB_G0281381", "name": "dstA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BD4", "map_id": "Q54BD4", "name": "dstC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293532", "map_id": "DDB_G0293532", "name": "dstC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q70GP4", "map_id": "Q70GP4", "name": "dstB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268638", "map_id": "DDB_G0268638", "name": "dstB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86I20", "map_id": "Q86I20", "name": "dstD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275167", "map_id": "DDB_G0275167", "name": "dstD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10594334", "map_id": "none", "name": "p-Y701-STAT1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10597154", "map_id": "none", "name": "Activation of ISG15 by UBA7 E1 ligase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. 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For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10595036", "map_id": "Q55C16", "name": "uba1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0270272", "map_id": "DDB_G0270272", "name": "uba1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_113592", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10595029", "map_id": "Q54CI1", "name": "ISG15", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0292984", "map_id": "DDB_G0292984", "name": "ISG15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_111294", "map_id": "CHEBI:29888", "name": "PPi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10597151", "map_id": "none", "name": "ISG15:UBA7", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54CI1", "map_id": "Q54CI1", "name": "ISG15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55C16", "map_id": "Q55C16", "name": "uba1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_76577", "map_id": "CHEBI:16027", "name": "AMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10597170", "map_id": "none", "name": "Transfer of ISG15 from E1 to E2 (UBCH8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. 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For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10596135", "map_id": "none", "name": "Homologues of NEDD4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "C7G034", "map_id": "C7G034", "name": "HUWE1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285063", "map_id": "DDB_G0285063", "name": "HUWE1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QF1", "map_id": "Q54QF1", "name": "HECW2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283983", "map_id": "DDB_G0283983", "name": "HECW2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10597156", "map_id": "none", "name": "ISG15:NEDD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10599224", "map_id": "none", "name": "Competitive inhibition of translation initiation by ISGylated 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. 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For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10599208", "map_id": "none", "name": "ISGylated 4EHP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "B0G0Z1", "map_id": "B0G0Z1", "name": "EIF4E2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284841", "map_id": "DDB_G0284841", "name": "EIF4E2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54E38", "map_id": "Q54E38", "name": "EIF4E3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291820", "map_id": "DDB_G0291820", "name": "EIF4E3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BQ5", "map_id": "Q55BQ5", "name": "EIF4E2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54P37", "map_id": "Q54P37", "name": "EIF4E2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54T63", "map_id": "Q54T63", "name": "EIF4E2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54D12", "map_id": "Q54D12", "name": "HERC6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292586", "map_id": "DDB_G0292586", "name": "HERC6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NH2", "map_id": "Q54NH2", "name": "HERC6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Q67", "map_id": "Q54Q67", "name": "HERC6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54I29", "map_id": "Q54I29", "name": "ARIH2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289043", "map_id": "DDB_G0289043", "name": "ARIH2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10599220", "map_id": "none", "name": "eIF4F:mRNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55FE0", "map_id": "Q55FE0", "name": "eif4e", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268574", "map_id": "DDB_G0268574", "name": "eif4e", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q553R3", "map_id": "Q553R3", "name": "eif4g", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275395", "map_id": "DDB_G0275395", "name": "eif4g", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55D61", "map_id": "Q55D61", "name": "tifA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269192", "map_id": "DDB_G0269192", "name": "tifA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90529", "map_id": "P90529", "name": "ifdA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269146", "map_id": "DDB_G0269146", "name": "ifdA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10599222", "map_id": "none", "name": "ISGylated 4EHP:mRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10599218", "map_id": "none", "name": "EIF4F", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10597192", "map_id": "none", "name": "ISGylation of host proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10597149", "map_id": "none", "name": "ISG15:UBCH8:ISG15 E3 ligase", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10597188", "map_id": "none", "name": "ISG15 targets", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10597147", "map_id": "none", "name": "ISG15 E3 ligases", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10597190", "map_id": "none", "name": "ISGylated host proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10599179", "map_id": "none", "name": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_141681", "map_id": "none", "name": "polypeptide", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10599176", "map_id": "none", "name": "USP18-like proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54DT4", "map_id": "Q54DT4", "name": "USP18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292046", "map_id": "DDB_G0292046", "name": "USP18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q553T4", "map_id": "Q553T4", "name": "USP9X", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275415", "map_id": "DDB_G0275415", "name": "USP9X", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599226", "map_id": "none", "name": "ISGylation of protein translation regulator 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10599206", "map_id": "none", "name": "Homologues of EIF4E2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10597165", "map_id": "none", "name": "ISGylation of E2 conjugating enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10597160", "map_id": "none", "name": "E2 congugating enzymes", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86K32", "map_id": "Q86K32", "name": "ube2n", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277267", "map_id": "DDB_G0277267", "name": "ube2n", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10597162", "map_id": "none", "name": "ISGylated E2 conjugating enzymes", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10597167", "map_id": "none", "name": "Interaction of E3 ligase with ISG15:E2 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10594178", "map_id": "none", "name": "Translocation of STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10594164", "map_id": "none", "name": "IFNG-activated factor (GAF)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10594176", "map_id": "none", "name": "IFNG-activated factor (GAF)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10594217", "map_id": "none", "name": "PIAS1 binds p-STAT1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10594201", "map_id": "none", "name": "Homologues of PIAS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54V57", "map_id": "Q54V57", "name": "PIAS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280603", "map_id": "DDB_G0280603", "name": "PIAS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q555X5", "map_id": "Q555X5", "name": "pisA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274743", "map_id": "DDB_G0274743", "name": "pisA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10594213", "map_id": "none", "name": "Homologues of SUMO1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q8N0B4", "map_id": "Q8N0B4", "name": "SUMO", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286189", "map_id": "DDB_G0286189", "name": "SUMO", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FZ7", "map_id": "Q55FZ7", "name": "UBE2I-G97-SUMO1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267886", "map_id": "DDB_G0267886", "name": "UBE2I-G97-SUMO1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10594215", "map_id": "none", "name": "p-STAT1 dimer:PIAS:SUMO1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10612656", "map_id": "none", "name": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10612625", "map_id": "none", "name": "p-Y705-STAT3 dimer, p-Y614-STAT6 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10612654", "map_id": "none", "name": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10612627", "map_id": "none", "name": "p-Y705-STAT3, p-Y641-STAT6 dimerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10612621", "map_id": "none", "name": "p-Y705-STAT3,p-Y641-STAT6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10612900", "map_id": "none", "name": "Expression of HSP90B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10612898", "map_id": "Q9NKX1", "name": "grp94", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "DDB_G0280057", "map_id": "DDB_G0280057", "name": "grp94", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10597019", "map_id": "none", "name": "p-Y705-STAT3 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10612808", "map_id": "none", "name": "p-Y-STATs dimerize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10612804", "map_id": "none", "name": "p-Y701-STAT1,p-Y705-STAT3,p-Y641-STAT6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10612806", "map_id": "none", "name": "p-Y701-STAT1 dimer,p-Y705-STAT3 dimer,p-Y641-STAT6 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10612812", "map_id": "none", "name": "p-Y-STATs translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10612810", "map_id": "none", "name": "p-Y701-STAT1 dimer,p-Y705-STAT3 dimer,p-Y641-STAT6 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10592978", "map_id": "none", "name": "TXLNA (IL14) binds syntaxin1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10592964", "map_id": "Q54HM5", "name": "STX1A", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0289379", "map_id": "DDB_G0289379", "name": "STX1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10592962", "map_id": "Q54GD1", "name": "TXLNA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0290231", "map_id": "DDB_G0290231", "name": "TXLNA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10592966", "map_id": "none", "name": "TXLNA:STX1A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54GD1", "map_id": "Q54GD1", "name": "TXLNA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HM5", "map_id": "Q54HM5", "name": "STX1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10592976", "map_id": "none", "name": "STXA1:SNAP25,STXBP2, VAMP2", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54QC8", "map_id": "Q54QC8", "name": "sec1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283937", "map_id": "DDB_G0283937", "name": "sec1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ZW8", "map_id": "Q54ZW8", "name": "scfd2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277343", "map_id": "DDB_G0277343", "name": "scfd2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YE6", "map_id": "Q54YE6", "name": "culC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284903", "map_id": "DDB_G0284903", "name": "culC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GN5", "map_id": "Q55GN5", "name": "SNAP23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267590", "map_id": "DDB_G0267590", "name": "SNAP23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10624948", "map_id": "none", "name": "TXLNA (IL14) binds syntaxin3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10624944", "map_id": "none", "name": "Homologues of STX3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q55DR2", "map_id": "Q55DR2", "name": "STX4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270556", "map_id": "DDB_G0270556", "name": "STX4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10624946", "map_id": "none", "name": "TXLNA:STX3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10624952", "map_id": "none", "name": "TXLNA (IL14) binds syntaxin4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10589716", "map_id": "none", "name": "Homologues of STX4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10624950", "map_id": "none", "name": "TXLNA:STX4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10593044", "map_id": "none", "name": "Phosphorylated MKK3/MKK6 migrates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10593036", "map_id": "none", "name": "p-S189,T193-MAP2K3, p-S207,T211-MAP2K6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54HS0", "map_id": "Q54HS0", "name": "MAP2K6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289277", "map_id": "DDB_G0289277", "name": "MAP2K6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10593042", "map_id": "none", "name": "p-S189,T193-MAP2K3, p-S207,T211-MAP2K6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10593080", "map_id": "none", "name": "activated human TAK1 phosphorylates MKK3/MKK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10593078", "map_id": "none", "name": "MAP2K3,MAP2K6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_29370", "map_id": "CHEBI:456216", "name": "ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10593069", "map_id": "none", "name": "p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P0CG78", "map_id": "P0CG78", "name": "ubqF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289449", "map_id": "DDB_G0289449", "name": "ubqF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P0CG79", "map_id": "P0CG79", "name": "ubqG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282369", "map_id": "DDB_G0282369", "name": "ubqG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P0CG80", "map_id": "P0CG80", "name": "ubqI", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291928", "map_id": "DDB_G0291928", "name": "ubqI", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P0CG81", "map_id": "P0CG81", "name": "ubqH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279721", "map_id": "DDB_G0279721", "name": "ubqH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P0CG88", "map_id": "P0CG88", "name": "ubqJ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269458", "map_id": "DDB_G0269458", "name": "ubqJ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P14797", "map_id": "P14797", "name": "ubqC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276765", "map_id": "DDB_G0276765", "name": "ubqC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P0CG76", "map_id": "P0CG76", "name": "ubqA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282295", "map_id": "DDB_G0282295", "name": "ubqA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FC5", "map_id": "Q54FC5", "name": "TRAF6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293202", "map_id": "DDB_G0293202", "name": "TRAF6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GA0", "map_id": "Q55GA0", "name": "TRAF6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GA8", "map_id": "Q55GA8", "name": "TRAF6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FD5", "map_id": "Q54FD5", "name": "TRAF6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FG0", "map_id": "Q54FG0", "name": "TRAF6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86AY4", "map_id": "Q86AY4", "name": "TRAF6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86K46", "map_id": "Q86K46", "name": "TRAF6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IP3", "map_id": "Q54IP3", "name": "TRAF6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NN4", "map_id": "Q54NN4", "name": "TRAF6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86KX6", "map_id": "Q86KX6", "name": "TRAF6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86L54", "map_id": "Q86L54", "name": "TRAF6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WD3", "map_id": "Q54WD3", "name": "TRAF6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YP8", "map_id": "Q54YP8", "name": "TRAF6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P11467", "map_id": "P11467", "name": "zfaA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290961", "map_id": "DDB_G0290961", "name": "zfaA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXR0", "map_id": "Q1ZXR0", "name": "TRAF6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q557K0", "map_id": "Q557K0", "name": "TRAF6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q557K2", "map_id": "Q557K2", "name": "TRAF6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54C11", "map_id": "Q54C11", "name": "TRAF6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54F79", "map_id": "Q54F79", "name": "TRAF6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q559R2", "map_id": "Q559R2", "name": "TRAF6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55A66", "map_id": "Q55A66", "name": "TRAF6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FB9", "map_id": "Q54FB9", "name": "TRAF6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LU8", "map_id": "Q54LU8", "name": "phospho-p-IRAK2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286465", "map_id": "DDB_G0286465", "name": "phospho-p-IRAK2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10587141", "map_id": "none", "name": "ERK1/2/5 activate RSK1/2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_29358", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10587082", "map_id": "none", "name": "Ribosomal protein S6 kinase", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q8MYF1", "map_id": "Q8MYF1", "name": "RPS6KA3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277449", "map_id": "DDB_G0277449", "name": "RPS6KA3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34102", "map_id": "P34102", "name": "pkgC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286125", "map_id": "DDB_G0286125", "name": "pkgC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_113582", "map_id": "CHEBI:456216", "name": "ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10587136", "map_id": "none", "name": "Phospho-Ribosomal protein S6 kinase", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10587138", "map_id": "none", "name": "p-T1218, Y220 MAPK7 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P42525", "map_id": "P42525", "name": "erkA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286353", "map_id": "DDB_G0286353", "name": "erkA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10587284", "map_id": "none", "name": "ERKs are inactivated by protein phosphatase 2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_113518", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_113550", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10587274", "map_id": "none", "name": "MAPK7 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10587281", "map_id": "none", "name": "PP2A-ABdeltaC complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54VB6", "map_id": "Q54VB6", "name": "psrA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280469", "map_id": "DDB_G0280469", "name": "psrA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10587820", "map_id": "none", "name": "ERKs are inactivated by dual-specific phosphatases (DUSPs)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10587817", "map_id": "none", "name": "ERK-specific DUSP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55BI8", "map_id": "Q55BI8", "name": "DUSP7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285449", "map_id": "DDB_G0285449", "name": "DUSP7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54N84", "map_id": "Q54N84", "name": "DUSP7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Y32", "map_id": "Q54Y32", "name": "mpl3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278445", "map_id": "DDB_G0278445", "name": "mpl3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q556Y8", "map_id": "Q556Y8", "name": "DUSP7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10593072", "map_id": "none", "name": "Activated TAK1 phosphorylates MKK4/MKK7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10593050", "map_id": "none", "name": "MAP2K7,MAP2K4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10593060", "map_id": "none", "name": "p-MAP2K4/p-MAP2K7", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10624354", "map_id": "none", "name": "p-Y-STAT3 binds p-STAT5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10624350", "map_id": "none", "name": "Homologues of p-Y705-STAT3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10624340", "map_id": "none", "name": "p-Y649-STAT5A, p-STAT5B", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10624352", "map_id": "none", "name": "p-Y-STAT3:p-STAT5A,p-STAT5B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10624388", "map_id": "none", "name": "p-Y-STAT3:p-STAT5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10624386", "map_id": "none", "name": "p-Y-STAT3:p-STAT5A,p-STAT5B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10624407", "map_id": "none", "name": "p-Y701-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10624403", "map_id": "none", "name": "Homologues of p-Y701-STAT1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10624405", "map_id": "none", "name": "p-Y-STAT1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10624411", "map_id": "none", "name": "p-Y649-STAT5A, p-STAT5B dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10624409", "map_id": "none", "name": "p-STAT5A,p-STAT5B dimer", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10624415", "map_id": "none", "name": "p-Y701-STAT1 binds p-Y705-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10624413", "map_id": "none", "name": "p-Y701-STAT1:p-Y705-STAT3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10624429", "map_id": "none", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10624427", "map_id": "none", "name": "p-Y701-STAT1:p-Y705-STAT3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10597005", "map_id": "none", "name": "Phosphorylated STAT1, STAT3 form dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10596997", "map_id": "none", "name": "p-Y701-STAT1, p-Y705-STAT3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10597003", "map_id": "none", "name": "p-Y701-STAT1 dimer,p-Y705-STAT3 dimer,p-Y701-STAT1:p-Y705-STAT3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10597023", "map_id": "none", "name": "STAT1 and STAT3 dimers translocate to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10597021", "map_id": "none", "name": "STAT1/3 homo and heterodimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10624538", "map_id": "none", "name": "STAT3 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10589922", "map_id": "none", "name": "Homologues of STAT3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10593345", "map_id": "none", "name": "Pellino ubiquitinates IRAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10593334", "map_id": "none", "name": "hp-IRAK1: p-Pellino-1,2,(3):UBE2N:UBE2V1:K63polyUb", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54D06", "map_id": "Q54D06", "name": "ube2v", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292596", "map_id": "DDB_G0292596", "name": "ube2v", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10593342", "map_id": "none", "name": "K63polyUb-hp-IRAK1:p-Pellino-1,2,(3):UBE2N:UBE2V1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10593026", "map_id": "none", "name": "IRAK1 induces oligomerisation of TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10592841", "map_id": "none", "name": "p-2S,S376,T,T209,T387-IRAK1:TRAF6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10584497", "map_id": "none", "name": "Homologues of TRAF6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10592843", "map_id": "none", "name": "hp-IRAK1:3xTRAF6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10623333", "map_id": "none", "name": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10592845", "map_id": "none", "name": "UBE2N:UBE2V1:K63polyUb", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10592847", "map_id": "none", "name": "hp-IRAK1:3xTRAF6:3xUBE2N:UBE2V1:K63polyUb", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10592922", "map_id": "none", "name": "TRAF6 is K63 poly-ubiquitinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10592919", "map_id": "none", "name": "hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10623337", "map_id": "none", "name": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10587623", "map_id": "none", "name": "UBE2N:UBE2V1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10623335", "map_id": "none", "name": "hp-IRAK1:3xK63polyUb-TRAF6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10593870", "map_id": "none", "name": "p62:MEKK3 binds to TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10593866", "map_id": "none", "name": "MAP3K3:SQSTM1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55CE3", "map_id": "Q55CE3", "name": "SQSTM1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270098", "map_id": "DDB_G0270098", "name": "SQSTM1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PX0", "map_id": "Q54PX0", "name": "MAP3K3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284251", "map_id": "DDB_G0284251", "name": "MAP3K3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CA6", "map_id": "Q55CA6", "name": "MAP3K3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T2I8", "map_id": "Q8T2I8", "name": "sepA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276465", "map_id": "DDB_G0276465", "name": "sepA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10593868", "map_id": "none", "name": "MAP3K3:SQSTM1:TRAF6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10619777", "map_id": "none", "name": "BRWD1 binds SMARCA4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10619773", "map_id": "Q54MP8", "name": "BRWD1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0285837", "map_id": "DDB_G0285837", "name": "PHIP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10602136", "map_id": "Q55C32", "name": "SMARCA4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0271052", "map_id": "DDB_G0271052", "name": "SMARCA4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10619775", "map_id": "none", "name": "BRWD1:SMARCA4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55C32", "map_id": "Q55C32", "name": "SMARCA4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MP8", "map_id": "Q54MP8", "name": "PHIP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10619802", "map_id": "none", "name": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10619780", "map_id": "Q54F38", "name": "phospho-H3v1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0291185", "map_id": "DDB_G0291185", "name": "H3v1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10619800", "map_id": "none", "name": "BRWD1:AcK(9,14,18,79)-p(S10,T11)-histone H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54F38", "map_id": "Q54F38", "name": "H3v1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10623473", "map_id": "none", "name": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10623469", "map_id": "none", "name": "p-Y705-STAT3:p-Y693-STAT4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10623471", "map_id": "none", "name": "p-Y705-STAT3:p-Y693-STAT4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10623479", "map_id": "none", "name": "p-Y705-STAT3 binds p-Y693-STAT4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10623421", "map_id": "none", "name": "Homologues of p-Y693-STAT4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10596995", "map_id": "none", "name": "Homologues of p-Y705-STAT3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10623467", "map_id": "none", "name": "p-STAT1:p-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10623463", "map_id": "none", "name": "p-STAT1:p-STAT4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10623465", "map_id": "none", "name": "p-Y693-STAT4:p-Y701-STAT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10623475", "map_id": "none", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10597001", "map_id": "none", "name": "p-Y701-STAT1: p-Y-705-STAT3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10597017", "map_id": "none", "name": "p-Y701-STAT1:p-Y705-STAT3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10623481", "map_id": "none", "name": "p-STAT1 binds p-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10594320", "map_id": "none", "name": "Homologues of p-Y701-STAT1-1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10623477", "map_id": "none", "name": "p-Y693-STAT4 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10623423", "map_id": "none", "name": "p-Y693-STAT4 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10623437", "map_id": "none", "name": "Y693-STAT4 dimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10623435", "map_id": "none", "name": "Y963-STAT4 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10624465", "map_id": "none", "name": "p-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10623451", "map_id": "none", "name": "Homologues of p-STAT1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10624463", "map_id": "none", "name": "2 x p-STAT1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10612568", "map_id": "none", "name": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10596999", "map_id": "none", "name": "p-Y705-STAT3 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10624491", "map_id": "none", "name": "p-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10624477", "map_id": "none", "name": "2 x p-STAT3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10624489", "map_id": "none", "name": "2xp-STAT3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10612570", "map_id": "none", "name": "p-Y705-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10624495", "map_id": "none", "name": "p-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10624475", "map_id": "none", "name": "Homologues of p-STAT3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10624509", "map_id": "none", "name": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10624507", "map_id": "none", "name": "2 x p-STAT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10603411", "map_id": "none", "name": "PAK1 binds RAC1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10590366", "map_id": "none", "name": "PAK1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55DD4", "map_id": "Q55DD4", "name": "pakD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269696", "map_id": "DDB_G0269696", "name": "pakD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GV3", "map_id": "Q55GV3", "name": "pakC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267450", "map_id": "DDB_G0267450", "name": "pakC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55D99", "map_id": "Q55D99", "name": "pakA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269166", "map_id": "DDB_G0269166", "name": "pakA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q869N2", "map_id": "Q869N2", "name": "pakB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276459", "map_id": "DDB_G0276459", "name": "pakB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10588143", "map_id": "none", "name": "RAC1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P34144", "map_id": "P34144", "name": "rac1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277869", "map_id": "DDB_G0277869", "name": "rac1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29438", "map_id": "CHEBI:15996", "name": "GTP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10603409", "map_id": "none", "name": "RAC1:GTP:PAK1 dimer:RAC1:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10603426", "map_id": "none", "name": "PAK1 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10603423", "map_id": "none", "name": "RAC1-GTP:p-S144,T423-PAK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10611057", "map_id": "none", "name": "PPT1 hydrolyses palmitoylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1605715", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_5690533", "map_id": "none", "name": "PALM:protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_3632881", "map_id": "CHEBI:15756", "name": "PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6785219", "map_id": "CHEBI:36080", "name": "protein", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_5690516", "map_id": "CHEBI:15756", "name": "PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10611054", "map_id": "Q54N35", "name": "PPT1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "DDB_G0285533", "map_id": "DDB_G0285533", "name": "PPT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10624098", "map_id": "none", "name": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_8957387", "map_id": "CHEBI:15456", "name": "3HA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_8957386", "map_id": "CHEBI:50998", "name": "t2E-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113521", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10624095", "map_id": "Q54T75", "name": "HTD2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0281965", "map_id": "DDB_G0281965", "name": "HTD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10593969", "map_id": "none", "name": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_548819", "map_id": "CHEBI:15514", "name": "AA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29508", "map_id": "CHEBI:15531", "name": "Mal-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_113528", "map_id": "CHEBI:16526", "name": "CO2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_548816", "map_id": "CHEBI:63821", "name": "3ODCT-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_76194", "map_id": "CHEBI:15346", "name": "CoA-SH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10593966", "map_id": "none", "name": "ELOVL1,2,3,5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q55BY4", "map_id": "Q55BY4", "name": "ELOVL2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271066", "map_id": "DDB_G0271066", "name": "ELOVL2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C7FZW5", "map_id": "C7FZW5", "name": "ELOVL2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10593985", "map_id": "none", "name": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_70106", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29364", "map_id": "CHEBI:16474", "name": "NADPH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_548812", "map_id": "CHEBI:50571", "name": "3OOD-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_548836", "map_id": "CHEBI:50583", "name": "3HODC-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29366", "map_id": "CHEBI:18009", "name": "NADP+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10593982", "map_id": "none", "name": "HSD17B3,12", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q869Y3", "map_id": "Q869Y3", "name": "HSD17B3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275049", "map_id": "DDB_G0275049", "name": "HSD17B3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10593995", "map_id": "none", "name": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_548809", "map_id": "CHEBI:50570", "name": "TOD-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_428139", "map_id": "CHEBI:15541", "name": "ST-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10593990", "map_id": "Q55C17", "name": "gpsn2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0270270", "map_id": "DDB_G0270270", "name": "gpsn2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10593978", "map_id": "none", "name": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_200993", "map_id": "CHEBI:15525", "name": "PALM-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10593975", "map_id": "none", "name": "Homologues of ELOVL7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10587452", "map_id": "none", "name": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29356", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10587449", "map_id": "none", "name": "ACSL1,3,5,6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54JK0", "map_id": "Q54JK0", "name": "ACSL1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288001", "map_id": "DDB_G0288001", "name": "ACSL1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DR6", "map_id": "Q55DR6", "name": "fcsA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269242", "map_id": "DDB_G0269242", "name": "fcsA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXQ4", "map_id": "Q1ZXQ4", "name": "fcsB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269474", "map_id": "DDB_G0269474", "name": "fcsB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10593980", "map_id": "none", "name": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_548794", "map_id": "CHEBI:15527", "name": "ICS-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_548829", "map_id": "CHEBI:52328", "name": "3ODC-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10607615", "map_id": "none", "name": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_5676631", "map_id": "CHEBI:15456", "name": "VLC3HA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5676634", "map_id": "CHEBI:50998", "name": "2,3-TE-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10607612", "map_id": "none", "name": "PTPLs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54Y54", "map_id": "Q54Y54", "name": "PTPLA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278683", "map_id": "DDB_G0278683", "name": "PTPLA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YR9", "map_id": "Q54YR9", "name": "PTPLB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278113", "map_id": "DDB_G0278113", "name": "PTPLB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10611854", "map_id": "none", "name": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5695985", "map_id": "CHEBI:27283", "name": "VLCFA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5695971", "map_id": "CHEBI:61910", "name": "VLCFA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10611851", "map_id": "none", "name": "ACSBG1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55CD5", "map_id": "Q55CD5", "name": "ACSBG1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270106", "map_id": "DDB_G0270106", "name": "ACSBG1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10611870", "map_id": "none", "name": "ACSF3 ligates CoA-SH to VLCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_29374", "map_id": "CHEBI:15346", "name": "CoA-SH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5696008", "map_id": "CHEBI:27283", "name": "VLCFA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113593", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_159448", "map_id": "CHEBI:16027", "name": "adenosine 5'-monophosphate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_159450", "map_id": "CHEBI:29888", "name": "PPi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5696003", "map_id": "CHEBI:61910", "name": "VLCFA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10611867", "map_id": "Q54HD3", "name": "ACSF3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0289539", "map_id": "DDB_G0289539", "name": "ACSF3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10587362", "map_id": "none", "name": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111627", "map_id": "CHEBI:17544", "name": "HCO3-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_76183", "map_id": "CHEBI:15351", "name": "Ac-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29372", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10581617", "map_id": "Q54J08", "name": "accA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_76190", "map_id": "CHEBI:30769", "name": "CIT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10581606", "map_id": "none", "name": "ACLY tetramer transforms CIT to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_76213", "map_id": "CHEBI:30744", "name": "OA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10581603", "map_id": "none", "name": "ACLY tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54YA2", "map_id": "Q54YA2", "name": "ACLY", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278341", "map_id": "DDB_G0278341", "name": "ACLY", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10581675", "map_id": "none", "name": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10581672", "map_id": "none", "name": "FASN dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10584076", "map_id": "none", "name": "Formation of fatty acid synthase (FAS) dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10625008", "map_id": "none", "name": "HRSP12 deaminates 2AA to 2OBUTA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9014643", "map_id": "CHEBI:58020", "name": "2AA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29382", "map_id": "CHEBI:16134", "name": "NH3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_936714", "map_id": "CHEBI:30831", "name": "2OBUTA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10625005", "map_id": "Q86KR5", "name": "Q86KR5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0277761", "map_id": "DDB_G0277761", "name": "Q86KR5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625000", "map_id": "none", "name": "SDS dimers:PXLP dehydrate L-Thr to 2AA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_351990", "map_id": "CHEBI:57926", "name": "L-Thr", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10624997", "map_id": "none", "name": "PXLP-SDS dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86B06", "map_id": "Q86B06", "name": "sds", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272787", "map_id": "DDB_G0272787", "name": "sds", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10585185", "map_id": "none", "name": "Ral-GDS binds to Ras-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10585181", "map_id": "none", "name": "Homologues of RALGDS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8IS18", "map_id": "Q8IS18", "name": "gefE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269252", "map_id": "DDB_G0269252", "name": "gefE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WL2", "map_id": "Q54WL2", "name": "RASGRF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279569", "map_id": "DDB_G0279569", "name": "RASGRF2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q552M5", "map_id": "Q552M5", "name": "gefY", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276019", "map_id": "DDB_G0276019", "name": "gefY", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IS19", "map_id": "Q8IS19", "name": "gefD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289667", "map_id": "DDB_G0289667", "name": "gefD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8SSQ3", "map_id": "Q8SSQ3", "name": "gefM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274607", "map_id": "DDB_G0274607", "name": "gefM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54L90", "map_id": "Q54L90", "name": "gflB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286773", "map_id": "DDB_G0286773", "name": "gflB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86G47", "map_id": "Q86G47", "name": "gefQ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289665", "map_id": "DDB_G0289665", "name": "gefQ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10585144", "map_id": "none", "name": "p21 RAS:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q55CB0", "map_id": "Q55CB0", "name": "rasU", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270138", "map_id": "DDB_G0270138", "name": "rasU", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CB7", "map_id": "Q55CB7", "name": "rasY", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270126", "map_id": "DDB_G0270126", "name": "rasY", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CB8", "map_id": "Q55CB8", "name": "rasX", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270124", "map_id": "DDB_G0270124", "name": "rasX", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CB9", "map_id": "Q55CB9", "name": "rasV", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270736", "map_id": "DDB_G0270736", "name": "rasV", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P03967", "map_id": "P03967", "name": "rasD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292996", "map_id": "DDB_G0292996", "name": "rasD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P15064", "map_id": "P15064", "name": "rasG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293434", "map_id": "DDB_G0293434", "name": "rasG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CC0", "map_id": "Q55CC0", "name": "rasW", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270122", "map_id": "DDB_G0270122", "name": "rasW", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q75J93", "map_id": "Q75J93", "name": "cpras1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277381", "map_id": "DDB_G0277381", "name": "cpras1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P32252", "map_id": "P32252", "name": "rasB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292998", "map_id": "DDB_G0292998", "name": "rasB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P32253", "map_id": "P32253", "name": "rasC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281385", "map_id": "DDB_G0281385", "name": "rasC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P32254", "map_id": "P32254", "name": "rasS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283537", "map_id": "DDB_G0283537", "name": "rasS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QY0", "map_id": "Q54QY0", "name": "rsmA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283547", "map_id": "DDB_G0283547", "name": "rsmA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VD5", "map_id": "Q54VD5", "name": "S-Farn-Me-PalmS KRAS4A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280437", "map_id": "DDB_G0280437", "name": "S-Farn-Me-PalmS KRAS4A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CA9", "map_id": "Q55CA9", "name": "rasZ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270140", "map_id": "DDB_G0270140", "name": "rasZ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10585183", "map_id": "none", "name": "Ras-GTP:RalGDS complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10626117", "map_id": "none", "name": "SGK phosphorylates SRF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10626105", "map_id": "Q54TY7", "name": "srfA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0281387", "map_id": "DDB_G0281387", "name": "phospho-srfA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10626108", "map_id": "Q54TY7", "name": "phospho-srfA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10626114", "map_id": "none", "name": "Homologues of p-T256,S422-SGK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54IF2", "map_id": "Q54IF2", "name": "phospho-p-T256,S422-SGK1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288795", "map_id": "DDB_G0288795", "name": "phospho-p-T256,S422-SGK1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54644", "map_id": "P54644", "name": "phospho-pkbA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268620", "map_id": "DDB_G0268620", "name": "phospho-pkbA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10587062", "map_id": "none", "name": "ERK5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10587058", "map_id": "P42525", "name": "phospho-erkA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10587060", "map_id": "P42525", "name": "phospho-erkA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10591923", "map_id": "none", "name": "PAN2-PAN3 complex partially deadenylates mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10591908", "map_id": "none", "name": "Translatable mRNA Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q75K16", "map_id": "Q75K16", "name": "EIF4B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275459", "map_id": "DDB_G0275459", "name": "EIF4B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BM2", "map_id": "Q54BM2", "name": "pabpc1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293558", "map_id": "DDB_G0293558", "name": "pabpc1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10591904", "map_id": "none", "name": "Partially Deadenylated mRNA Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10591920", "map_id": "none", "name": "PAN2-PAN3 Complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55DD5", "map_id": "Q55DD5", "name": "pan2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269694", "map_id": "DDB_G0269694", "name": "pan2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P0CD65", "map_id": "P0CD65", "name": "pan3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279129", "map_id": "DDB_G0279129", "name": "pan3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10623223", "map_id": "none", "name": "ZCCHC6, ZCCHC11 are mRNA uridyltransferases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6782337", "map_id": "CHEBI:73747", "name": "uridine residue", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10623193", "map_id": "none", "name": "Uridylated partially Deadenylated mRNA Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10623220", "map_id": "none", "name": "ZCCHC6, ZCCHC11", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8T2J7", "map_id": "Q8T2J7", "name": "ZCCHC6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281431", "map_id": "DDB_G0281431", "name": "ZCCHC6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Y43", "map_id": "Q54Y43", "name": "ZCCHC6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TZ1", "map_id": "Q54TZ1", "name": "ZCCHC6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625515", "map_id": "none", "name": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9026293", "map_id": "CHEBI:140222", "name": "14(S)-Hp-DPAn-3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29368", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9026311", "map_id": "CHEBI:140258", "name": "MaR3n-3 DPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10591746", "map_id": "Q54W35", "name": "lipA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0279909", "map_id": "DDB_G0279909", "name": "lipA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625519", "map_id": "none", "name": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9025012", "map_id": "CHEBI:140220", "name": "14(S)-Hp-DHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9026307", "map_id": "CHEBI:140200", "name": "13,14(S)-epoxy-DPAn-3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10600421", "map_id": "none", "name": "ALOX12:Fe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86H96", "map_id": "Q86H96", "name": "ALOX12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275577", "map_id": "DDB_G0275577", "name": "ALOX12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54W35", "map_id": "Q54W35", "name": "lipA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_71067", "map_id": "CHEBI:29033", "name": "Fe2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10625517", "map_id": "none", "name": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9608444", "map_id": "CHEBI:53488", "name": "DPAn-3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10587587", "map_id": "none", "name": "eNOS synthesizes NO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29468", "map_id": "CHEBI:32682", "name": "L-Arg", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_202124", "map_id": "CHEBI:16480", "name": "NO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29968", "map_id": "CHEBI:16349", "name": "L-Cit", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10587584", "map_id": "none", "name": "p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_74112", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "O00897", "map_id": "O00897", "name": "calB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269104", "map_id": "DDB_G0269104", "name": "calB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P02599", "map_id": "P02599", "name": "calA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279407", "map_id": "DDB_G0279407", "name": "calA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7Z2B8", "map_id": "Q7Z2B8", "name": "mlcD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277917", "map_id": "DDB_G0277917", "name": "mlcD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54651", "map_id": "P54651", "name": "hspD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267400", "map_id": "DDB_G0267400", "name": "hspD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_917877", "map_id": "CHEBI:17627", "name": "heme", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_29426", "map_id": "CHEBI:29105", "name": "Zn2+", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_76629", "map_id": "CHEBI:17621", "name": "FMN", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "Q55CT1", "map_id": "Q55CT1", "name": "redB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269912", "map_id": "DDB_G0269912", "name": "redB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_113596", "map_id": "CHEBI:16238", "name": "FAD", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_29870", "map_id": "CHEBI:15372", "name": "BH4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5693375", "map_id": "CHEBI:25682", "name": "ADMA", "type": "inhibitor", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10587763", "map_id": "none", "name": "depalmitoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10587546", "map_id": "none", "name": "palmitoylated, myristoylated eNOS dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_76168", "map_id": "CHEBI:15756", "name": "PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17941", "compartment_display": "early endosome", "complex": "false" }, { "id": "species_10587591", "map_id": "none", "name": "myristoylated eNOS dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10587760", "map_id": "none", "name": "LYPLA1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54T49", "map_id": "Q54T49", "name": "LYPLA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282005", "map_id": "DDB_G0282005", "name": "LYPLA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10587749", "map_id": "none", "name": "palmitoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10587589", "map_id": "Q55CT1", "name": "redB", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10587719", "map_id": "Q55CT1", "name": "redB", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10587746", "map_id": "none", "name": "Homologues of ZDHHC21", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q54VH7", "map_id": "Q54VH7", "name": "ZDHHC21", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293930", "map_id": "DDB_G0293930", "name": "ZDHHC21", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86A83", "map_id": "Q86A83", "name": "ZDHHC21", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q552M6", "map_id": "Q552M6", "name": "ZDHHC21", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q555N7", "map_id": "Q555N7", "name": "ZDHHC21", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54B34", "map_id": "Q54B34", "name": "ZDHHC21", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598261", "map_id": "none", "name": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10587580", "map_id": "none", "name": "p-S1177-eNOS:CaM:HSP90:p-AKT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10598276", "map_id": "none", "name": "Salvage - Sepiapterin is reduced to BH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1497811", "map_id": "CHEBI:16095", "name": "sepiapterin", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1497857", "map_id": "CHEBI:15375", "name": "BH2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10597898", "map_id": "none", "name": "p-SPR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54GP3", "map_id": "Q54GP3", "name": "sprA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290009", "map_id": "DDB_G0290009", "name": "sprA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10587753", "map_id": "none", "name": "N-myristoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_184174", "map_id": "CHEBI:15532", "name": "MYS-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10587751", "map_id": "Q55CT1", "name": "redB", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10598265", "map_id": "none", "name": "BH2 binding can lead to eNOS uncoupling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10598263", "map_id": "none", "name": "p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10587773", "map_id": "none", "name": "eNOS translocation from Golgi to Caveolae", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "reaction_10587597", "map_id": "none", "name": "depalmitoylated eNOS translocates from plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10587595", "map_id": "none", "name": "myristoylated eNOS dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10598268", "map_id": "none", "name": "Uncoupled eNOS favours the formation of superoxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1222424", "map_id": "CHEBI:18421", "name": "O2.-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10587599", "map_id": "none", "name": "AKT1 binds eNOS complex via HSP90", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10587563", "map_id": "none", "name": "eNOS:CaM:HSP90", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10586949", "map_id": "none", "name": "Homologues of p-T308,S473-AKT1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10587571", "map_id": "none", "name": "eNOS:CaM:HSP90:p-AKT1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10587582", "map_id": "none", "name": "AKT1 phosphorylates eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10592001", "map_id": "none", "name": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_429974", "map_id": "none", "name": "mature mRNA (eukaryotic, capped and deadenylated)", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_109402", "map_id": "CHEBI:16695", "name": "UMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_113578", "map_id": "CHEBI:17345", "name": "GMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_109395", "map_id": "CHEBI:17361", "name": "CMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_429926", "map_id": "none", "name": "capped oligoribonucleotide", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10591998", "map_id": "none", "name": "Exosome:SKI complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54HV0", "map_id": "Q54HV0", "name": "DG1091", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289175", "map_id": "DDB_G0289175", "name": "DG1091", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54S59", "map_id": "Q54S59", "name": "wdr61", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282793", "map_id": "DDB_G0282793", "name": "wdr61", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86K90", "map_id": "Q86K90", "name": "SKIV2L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277211", "map_id": "DDB_G0277211", "name": "SKIV2L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BJ2", "map_id": "Q55BJ2", "name": "EXOSC9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271100", "map_id": "DDB_G0271100", "name": "EXOSC9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VM4", "map_id": "Q54VM4", "name": "exosc7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280251", "map_id": "DDB_G0280251", "name": "exosc7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CU6", "map_id": "Q54CU6", "name": "EXOSC8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292692", "map_id": "DDB_G0292692", "name": "EXOSC8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BB0", "map_id": "Q55BB0", "name": "EXOSC6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271396", "map_id": "DDB_G0271396", "name": "EXOSC6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54EU6", "map_id": "Q54EU6", "name": "EXOSC4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291328", "map_id": "DDB_G0291328", "name": "EXOSC4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Q83", "map_id": "Q54Q83", "name": "EXOSC5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284053", "map_id": "DDB_G0284053", "name": "EXOSC5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54EV5", "map_id": "Q54EV5", "name": "EXOSC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291310", "map_id": "DDB_G0291310", "name": "EXOSC2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54N99", "map_id": "Q54N99", "name": "EXOSC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285377", "map_id": "DDB_G0285377", "name": "EXOSC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BH9", "map_id": "Q54BH9", "name": "DIS3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293614", "map_id": "DDB_G0293614", "name": "DIS3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KWX9", "map_id": "Q7KWX9", "name": "exosc3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276783", "map_id": "DDB_G0276783", "name": "exosc3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QJ0", "map_id": "Q54QJ0", "name": "HBS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283769", "map_id": "DDB_G0283769", "name": "HBS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10597571", "map_id": "none", "name": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10597257", "map_id": "none", "name": "RBL1:E2F4:TFDP1,TFDP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54FX2", "map_id": "Q54FX2", "name": "phospho-rblA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290551", "map_id": "DDB_G0290551", "name": "phospho-rblA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KWP1", "map_id": "Q7KWP1", "name": "TFDP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276799", "map_id": "DDB_G0276799", "name": "TFDP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Q23", "map_id": "Q54Q23", "name": "phospho-p-S12-E2F6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284129", "map_id": "DDB_G0284129", "name": "phospho-p-S12-E2F6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10597559", "map_id": "none", "name": "Cyclin E/A:CDK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P34112", "map_id": "P34112", "name": "phospho-cdk1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272813", "map_id": "DDB_G0272813", "name": "phospho-cdk1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10597569", "map_id": "none", "name": "RBL1:E2F4:DP1/2:Cyclin E/A:CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10597575", "map_id": "none", "name": "p107 (RBL1) binds CyclinE/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10597255", "map_id": "Q54FX2", "name": "rblA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10597573", "map_id": "none", "name": "RBL1:Cyclin E/A:CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10597563", "map_id": "none", "name": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10597246", "map_id": "none", "name": "RBL2:E2F4,E2F5:TFDP1,TFDP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10597561", "map_id": "none", "name": "RBL2:E2F4/5:DP1/2:Cyclin E/A:CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10597274", "map_id": "none", "name": "Recruitment of HDAC1 by p130 (RBL2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10597270", "map_id": "Q55FN5", "name": "hdaA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0268024", "map_id": "DDB_G0268024", "name": "hdaA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10597272", "map_id": "none", "name": "HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55FN5", "map_id": "Q55FN5", "name": "hdaA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10597567", "map_id": "none", "name": "p130 (RBL2) binds Cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10597229", "map_id": "Q54FX2", "name": "rblA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10597565", "map_id": "none", "name": "RBL2:Cyclin E/A:CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10597278", "map_id": "none", "name": "Recruitment of HDAC1 by p107 (RBL1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10597276", "map_id": "none", "name": "HDAC1:RBL1:E2F4:TFDP1,TFDP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10586837", "map_id": "none", "name": "FLAD1 phosphorylates FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_73524", "map_id": "CHEBI:17621", "name": "FMN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29386", "map_id": "CHEBI:16238", "name": "FAD", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10586834", "map_id": "Q54RS3", "name": "FLAD1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0282955", "map_id": "DDB_G0282955", "name": "FLAD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586847", "map_id": "none", "name": "2xENPP1 hydrolyzes FAD to FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10586844", "map_id": "none", "name": "2xENPP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54MJ8", "map_id": "Q54MJ8", "name": "ENPP6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285897", "map_id": "DDB_G0285897", "name": "ENPP6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10604772", "map_id": "none", "name": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_5221122", "map_id": "CHEBI:29089", "name": "1,2-diacyl-glycerol 3-phosphate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_5221124", "map_id": "CHEBI:17815", "name": "DAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_10603651", "map_id": "none", "name": "LPIN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "Q75JA1", "map_id": "Q75JA1", "name": "LPIN1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271730", "map_id": "DDB_G0271730", "name": "LPIN1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10602755", "map_id": "none", "name": "ATP hydrolysis by HSP70", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602750", "map_id": "none", "name": "HSP40:HSP70:ATP:nascent protein", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P36415", "map_id": "P36415", "name": "hspB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269144", "map_id": "DDB_G0269144", "name": "hspB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VQ1", "map_id": "Q54VQ1", "name": "ddj1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280037", "map_id": "DDB_G0280037", "name": "ddj1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ED3", "map_id": "Q54ED3", "name": "dnaja1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291568", "map_id": "DDB_G0291568", "name": "dnaja1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10602752", "map_id": "none", "name": "HSP40:HSP70:ADP:nascent protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10602748", "map_id": "none", "name": "HSP40s", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10605698", "map_id": "none", "name": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10589012", "map_id": "Q55FM3", "name": "PTGES3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0268042", "map_id": "DDB_G0268042", "name": "PTGES3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10605696", "map_id": "none", "name": "HSP90:ATP:FKBP5:STIP1:HSP70:nascent protein", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54QI6", "map_id": "Q54QI6", "name": "FKBP5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283815", "map_id": "DDB_G0283815", "name": "FKBP5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DA8", "map_id": "Q54DA8", "name": "sti1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292404", "map_id": "DDB_G0292404", "name": "sti1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10602796", "map_id": "Q54DA8", "name": "sti1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10602861", "map_id": "none", "name": "HSP70:ATP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10605561", "map_id": "none", "name": "HSP90:ATP:FKBP5:PTGES3:nascent protein:", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55FM3", "map_id": "Q55FM3", "name": "PTGES3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10605704", "map_id": "none", "name": "SH binds SHR within the HSP90 chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5618094", "map_id": "none", "name": "SH", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_193057", "map_id": "CHEBI:17347", "name": "TEST", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_469662", "map_id": "CHEBI:16330", "name": "DHTEST", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:16973", "map_id": "CHEBI:16973", "name": "CHEBI:16973", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17650", "map_id": "CHEBI:17650", "name": "CHEBI:17650", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:27584", "map_id": "CHEBI:27584", "name": "CHEBI:27584", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_193055", "map_id": "CHEBI:17026", "name": "P4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10605702", "map_id": "none", "name": "HSP90:ATP:FKBP4:PTGES3:SHR", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10605571", "map_id": "none", "name": "HSP90:ATP:FKBP4:PTGES3:SHR:SH", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10605706", "map_id": "none", "name": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605688", "map_id": "none", "name": "HSP90:ATP:STIP1:HSP70:nascent protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10605557", "map_id": "Q54QI6", "name": "FKBP5", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10627342", "map_id": "none", "name": "NR3C1 binds NR3C1 agonists", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9678859", "map_id": "none", "name": "NR3C1 agonists", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10605575", "map_id": "none", "name": "HSP90:ATP:FKBP4:PTGES3:NR3C1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10627340", "map_id": "none", "name": "HSP90:ATP:FKBP4:PTGES3:NR3C1:NR3C1 agonists", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10605708", "map_id": "none", "name": "ATP binding to HSP90 triggers conformation change", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602808", "map_id": "none", "name": "HSP90:STIP1:HSP70:nascent protein", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10602863", "map_id": "none", "name": "HSP70 binds to HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602859", "map_id": "none", "name": "HSP40:nascent protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10605710", "map_id": "none", "name": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605690", "map_id": "none", "name": "HSP90:ATP:FKBP4:STIP1:HSP70:nascent protein", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10605565", "map_id": "none", "name": "HSP90:ATP:FKBP4:PTGES3:nascent protein:", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10627379", "map_id": "none", "name": "SH binds NR3C1 (in HSP90:ATP:FKBP4:PTGES3:NR3C1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605577", "map_id": "none", "name": "HSP90:ATP:FKBP4:PTGES3:NR3C1:SH", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10605685", "map_id": "none", "name": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605581", "map_id": "none", "name": "HSP90:ATP:PTGES3:FKBP52:SHR:SH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10605587", "map_id": "none", "name": "HSP90:ATP:PTGES3:FKBP52:NR3C1:SH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10605683", "map_id": "none", "name": "Dynein:Dynactin:microtubule", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P54703", "map_id": "P54703", "name": "dicA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280849", "map_id": "DDB_G0280849", "name": "dicA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86A88", "map_id": "Q86A88", "name": "dlcB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274815", "map_id": "DDB_G0274815", "name": "dlcB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CI8", "map_id": "Q54CI8", "name": "dync1li1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292904", "map_id": "DDB_G0292904", "name": "dync1li1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34036", "map_id": "P34036", "name": "dhcA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276355", "map_id": "DDB_G0276355", "name": "dhcA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VD6", "map_id": "Q54VD6", "name": "dynA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280435", "map_id": "DDB_G0280435", "name": "dynA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ZI7", "map_id": "Q54ZI7", "name": "dynC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277561", "map_id": "DDB_G0277561", "name": "dynC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54N50", "map_id": "Q54N50", "name": "dynB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285503", "map_id": "DDB_G0285503", "name": "dynB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P13021", "map_id": "P13021", "name": "acpA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267374", "map_id": "DDB_G0267374", "name": "acpA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P13022", "map_id": "P13022", "name": "acpB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272104", "map_id": "DDB_G0272104", "name": "acpB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JY2", "map_id": "Q54JY2", "name": "arpH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287739", "map_id": "DDB_G0287739", "name": "arpH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FM4", "map_id": "Q54FM4", "name": "dynF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290757", "map_id": "DDB_G0290757", "name": "dynF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VS0", "map_id": "Q54VS0", "name": "dynD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280175", "map_id": "DDB_G0280175", "name": "dynD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XU5", "map_id": "Q54XU5", "name": "dynE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278579", "map_id": "DDB_G0278579", "name": "dynE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54I79", "map_id": "Q54I79", "name": "arpA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288937", "map_id": "DDB_G0288937", "name": "arpA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29420", "map_id": "CHEBI:17552", "name": "GDP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10627419", "map_id": "none", "name": "Androgens binds AR (in the HSP90 chaperone complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8979218", "map_id": "none", "name": "Androgens", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_193079", "map_id": "CHEBI:16422", "name": "ANDST", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:29117", "map_id": "CHEBI:29117", "name": "CHEBI:29117", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10627413", "map_id": "none", "name": "HSP90:ATP:FKBP4:PTGES3:AR", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10627417", "map_id": "none", "name": "HSP90:ATP:FKBP4:PTGES3:AR:Androgens", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10602810", "map_id": "none", "name": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602802", "map_id": "none", "name": "HSP90:HSP90", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10605692", "map_id": "none", "name": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605563", "map_id": "Q54QI6", "name": "FKBP4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10605567", "map_id": "none", "name": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10584784", "map_id": "none", "name": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_73663", "map_id": "CHEBI:46245", "name": "CoQ", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10584773", "map_id": "none", "name": "ETF:FADH2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54YZ4", "map_id": "Q54YZ4", "name": "etfb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277991", "map_id": "DDB_G0277991", "name": "etfb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_31649", "map_id": "CHEBI:17877", "name": "FADH2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "Q54FD7", "map_id": "Q54FD7", "name": "etfa", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290927", "map_id": "DDB_G0290927", "name": "etfa", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_76633", "map_id": "CHEBI:17976", "name": "QH2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10584771", "map_id": "none", "name": "ETF:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10584781", "map_id": "Q54XM6", "name": "etfdh", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0278849", "map_id": "DDB_G0278849", "name": "etfdh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10612771", "map_id": "none", "name": "NUBPL transfers 4Fe-4S to Complex I subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10612759", "map_id": "none", "name": "NDUF subunits", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54NI6", "map_id": "Q54NI6", "name": "ndufs7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285239", "map_id": "DDB_G0285239", "name": "ndufs7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86K57", "map_id": "Q86K57", "name": "NDUFS8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277231", "map_id": "DDB_G0277231", "name": "NDUFS8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q34312", "map_id": "Q34312", "name": "nad11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0294052", "map_id": "DDB_G0294052", "name": "nad11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23883", "map_id": "Q23883", "name": "nad7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0294030", "map_id": "DDB_G0294030", "name": "nad7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10610755", "map_id": "none", "name": "NUBPL:4Fe-4S", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54F15", "map_id": "Q54F15", "name": "nubpl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291193", "map_id": "DDB_G0291193", "name": "nubpl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10610753", "map_id": "Q54F15", "name": "nubpl", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10612769", "map_id": "none", "name": "NDUF:4Fe-4S subunits", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10612787", "map_id": "none", "name": "NUBPL transfers 4Fe-4S to NDUFV1, V2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10612781", "map_id": "Q54F10", "name": "ndufv2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0291173", "map_id": "DDB_G0291173", "name": "ndufv2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10612776", "map_id": "Q54I90", "name": "ndufv1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0288875", "map_id": "DDB_G0288875", "name": "ndufv1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10612783", "map_id": "none", "name": "NDUFV1:4Fe-4S:FMN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q54I90", "map_id": "Q54I90", "name": "ndufv1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10612785", "map_id": "none", "name": "NDUFV2:4Fe-4S", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q54F10", "map_id": "Q54F10", "name": "ndufv2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10610757", "map_id": "none", "name": "NUBPL binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_169274", "map_id": "none", "name": "4Fe-4S", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10616447", "map_id": "none", "name": "NDUF subunits bind to form the IP subcomplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10612767", "map_id": "none", "name": "NDUFS8:2x4Fe-4S", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10615711", "map_id": "none", "name": "NDUFAF7:NDUFS2:2x4Fe-4S", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54S83", "map_id": "Q54S83", "name": "midA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282615", "map_id": "DDB_G0282615", "name": "midA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10612765", "map_id": "none", "name": "NDUFS7:4Fe-4S", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10615723", "map_id": "P22237", "name": "nad9", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0294032", "map_id": "DDB_G0294032", "name": "nad9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10615718", "map_id": "none", "name": "NDUFA9:FAD", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q559Z0", "map_id": "Q559Z0", "name": "ndufa9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272266", "map_id": "DDB_G0272266", "name": "ndufa9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10615725", "map_id": "none", "name": "IP subcomplex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P22237", "map_id": "P22237", "name": "nad9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10584776", "map_id": "none", "name": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10584136", "map_id": "none", "name": "Electron transfer from ubiquinol to cytochrome c of complex III", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_113529", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10584033", "map_id": "none", "name": "Cytochrome c (oxidised)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "CHEBI:38574", "map_id": "CHEBI:38574", "name": "CHEBI:38574", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q869N1", "map_id": "Q869N1", "name": "cytC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275537", "map_id": "DDB_G0275537", "name": "cytC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10584031", "map_id": "none", "name": "Cytochrome c (reduced)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "CHEBI:38573", "map_id": "CHEBI:38573", "name": "CHEBI:38573", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_163953", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10584133", "map_id": "none", "name": "Ubiquinol-cytochrome c reductase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q1ZXP3", "map_id": "Q1ZXP3", "name": "uqcrh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271774", "map_id": "DDB_G0271774", "name": "uqcrh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q37311", "map_id": "Q37311", "name": "cytB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0294078", "map_id": "DDB_G0294078", "name": "cytB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NW9", "map_id": "Q54NW9", "name": "ucr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284947", "map_id": "DDB_G0284947", "name": "ucr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54V76", "map_id": "Q54V76", "name": "UQCRQ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280569", "map_id": "DDB_G0280569", "name": "UQCRQ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q4W6B5", "map_id": "Q4W6B5", "name": "mppB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288777", "map_id": "DDB_G0288777", "name": "mppB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54M82", "map_id": "Q54M82", "name": "UQCRB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286171", "map_id": "DDB_G0286171", "name": "UQCRB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54D07", "map_id": "Q54D07", "name": "cyc1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292594", "map_id": "DDB_G0292594", "name": "cyc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QR8", "map_id": "Q54QR8", "name": "UQCR10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283669", "map_id": "DDB_G0283669", "name": "UQCR10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86A84", "map_id": "Q86A84", "name": "mppA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274809", "map_id": "DDB_G0274809", "name": "mppA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10616628", "map_id": "none", "name": "AKT phosphorylates KAT6A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10616601", "map_id": "none", "name": "KAT6A:ING5:MEAF6:BRPF1,(2,3)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54QM3", "map_id": "Q54QM3", "name": "BRPF3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283859", "map_id": "DDB_G0283859", "name": "BRPF3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B0G130", "map_id": "B0G130", "name": "phospho-p-T369-KAT6A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279699", "map_id": "DDB_G0279699", "name": "phospho-p-T369-KAT6A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q869X5", "map_id": "Q869X5", "name": "phospho-p-T369-KAT6A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NG3", "map_id": "Q54NG3", "name": "MEAF6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285275", "map_id": "DDB_G0285275", "name": "MEAF6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PN9", "map_id": "Q54PN9", "name": "dng1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284411", "map_id": "DDB_G0284411", "name": "dng1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10616626", "map_id": "none", "name": "p-T369-KAT6A:ING5:MEAF6:BRPF1,(2,3)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10587267", "map_id": "none", "name": "p-T,p-S-AKT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10622674", "map_id": "none", "name": "PIN1 binds phosphorylated PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10622667", "map_id": "none", "name": "p-S326-PIP4K2B dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55GN6", "map_id": "Q55GN6", "name": "PIP4K2A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292190", "map_id": "DDB_G0292190", "name": "PIP4K2A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86A02", "map_id": "Q86A02", "name": "PIPkinA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275635", "map_id": "DDB_G0275635", "name": "PIPkinA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86D86", "map_id": "Q86D86", "name": "rpkA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283615", "map_id": "DDB_G0283615", "name": "rpkA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54M96", "map_id": "Q54M96", "name": "PIP4K2A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DL4", "map_id": "Q54DL4", "name": "PIP4K2A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q556H0", "map_id": "Q556H0", "name": "PIP4K2A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VR4", "map_id": "Q54VR4", "name": "PIP4K2A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10594992", "map_id": "Q55EZ0", "name": "pinA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0268618", "map_id": "DDB_G0268618", "name": "pinA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10622672", "map_id": "none", "name": "p-S326-PIP4K2B dimers:PIN1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55EZ0", "map_id": "Q55EZ0", "name": "pinA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617814", "map_id": "none", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_6810408", "map_id": "CHEBI:16500", "name": "PI5P", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_6810412", "map_id": "CHEBI:18348", "name": "PI(4,5)P2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10617811", "map_id": "none", "name": "PIP4K2 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10617479", "map_id": "none", "name": "ING2 binds PI5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10603513", "map_id": "Q54PN9", "name": "dng1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10617477", "map_id": "none", "name": "ING2:PI5P", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "reaction_10622670", "map_id": "none", "name": "MAP2K6 phosphorylates PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10622656", "map_id": "none", "name": "PIP4K2B dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10593040", "map_id": "Q54HS0", "name": "phospho-p-S207,T211-MAP2K6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10616616", "map_id": "none", "name": "KAT6A acetylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10616607", "map_id": "none", "name": "KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:p-S15,S20-TP53", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54MF7", "map_id": "Q54MF7", "name": "PML", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285989", "map_id": "DDB_G0285989", "name": "PML", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_113560", "map_id": "CHEBI:15351", "name": "Ac-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_2485002", "map_id": "CHEBI:15346", "name": "CoA-SH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10616613", "map_id": "none", "name": "KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,K382,p-S15,S20-TP53 Tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10577937", "map_id": "none", "name": "PRODH oxidises L-Pro to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113597", "map_id": "CHEBI:16238", "name": "FAD", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_379717", "map_id": "CHEBI:60039", "name": "L-Pro", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_113590", "map_id": "CHEBI:17388", "name": "1PYR-5COOH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_164934", "map_id": "CHEBI:17877", "name": "FADH2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10577934", "map_id": "Q86H28", "name": "prodh", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0275669", "map_id": "DDB_G0275669", "name": "prodh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10623999", "map_id": "none", "name": "PRODH2 oxidises HPRO to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6784215", "map_id": "CHEBI:18240", "name": "HPRO", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10612516", "map_id": "Q86H28", "name": "prodh", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "reaction_10597318", "map_id": "none", "name": "RHAG transports CO2 from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1237009", "map_id": "CHEBI:16526", "name": "CO2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10592544", "map_id": "none", "name": "Homologues of RHAG", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q8I0L6", "map_id": "Q8I0L6", "name": "rhgB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280059", "map_id": "DDB_G0280059", "name": "rhgB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NIV0", "map_id": "Q9NIV0", "name": "rhgA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283389", "map_id": "DDB_G0283389", "name": "rhgA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10597320", "map_id": "none", "name": "AQP1 tetramer transports CO2 from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10592019", "map_id": "none", "name": "AQP1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9U8P7", "map_id": "Q9U8P7", "name": "aqpA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267378", "map_id": "DDB_G0267378", "name": "aqpA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10608673", "map_id": "none", "name": "FEN1 cleaves displaced ssDNA flaps during MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10608663", "map_id": "none", "name": "Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54EK9", "map_id": "Q54EK9", "name": "RBBP8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291466", "map_id": "DDB_G0291466", "name": "RBBP8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BN2", "map_id": "Q54BN2", "name": "MRE11A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293546", "map_id": "DDB_G0293546", "name": "MRE11A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CS9", "map_id": "Q54CS9", "name": "rad50", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292786", "map_id": "DDB_G0292786", "name": "rad50", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NU0", "map_id": "Q54NU0", "name": "repG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284987", "map_id": "DDB_G0284987", "name": "repG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10608670", "map_id": "none", "name": "Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10577480", "map_id": "Q54NU0", "name": "repG", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_68454", "map_id": "none", "name": "Flap", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10608661", "map_id": "none", "name": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_30555", "map_id": "CHEBI:16516", "name": "dNTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10608650", "map_id": "none", "name": "Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54S42", "map_id": "Q54S42", "name": "POLQ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282679", "map_id": "DDB_G0282679", "name": "POLQ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GU8", "map_id": "Q55GU8", "name": "adprt4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267468", "map_id": "DDB_G0267468", "name": "adprt4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HY5", "map_id": "Q54HY5", "name": "PAR-PARP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289141", "map_id": "DDB_G0289141", "name": "PAR-PARP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54X55", "map_id": "Q54X55", "name": "adprt1B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279195", "map_id": "DDB_G0279195", "name": "adprt1B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8I7C6", "map_id": "Q8I7C6", "name": "adprt2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292820", "map_id": "DDB_G0292820", "name": "adprt2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XI2", "map_id": "Q54XI2", "name": "adprt1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278741", "map_id": "DDB_G0278741", "name": "adprt1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_113541", "map_id": "CHEBI:29888", "name": "PPi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10608658", "map_id": "none", "name": "Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10608677", "map_id": "none", "name": "MRN recruits LIG3:XRCC1 to MMEJ sites", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10580807", "map_id": "none", "name": "LIG3:XRCC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q86H44", "map_id": "Q86H44", "name": "XRCC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275653", "map_id": "DDB_G0275653", "name": "XRCC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QM4", "map_id": "Q54QM4", "name": "lig3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283857", "map_id": "DDB_G0283857", "name": "lig3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10608675", "map_id": "none", "name": "Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10608666", "map_id": "none", "name": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_427523", "map_id": "CHEBI:57540", "name": "NAD+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_427497", "map_id": "CHEBI:17154", "name": "NAM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10606279", "map_id": "none", "name": "PAR-PARP1,PAR-PARP2 dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10608644", "map_id": "none", "name": "POLQ homodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10608637", "map_id": "none", "name": "MRN and RBBP8 resect DNA DSBs in MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10608630", "map_id": "none", "name": "DNA DSB:MRN:RBBP8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10608634", "map_id": "none", "name": "Microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10608652", "map_id": "none", "name": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10606233", "map_id": "none", "name": "PARP1,PARP2 dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10608369", "map_id": "none", "name": "CHEK1 phosphorylates RAD51", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10608364", "map_id": "Q557E6", "name": "RAD51", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0273139", "map_id": "DDB_G0273139", "name": "RAD51", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10608367", "map_id": "Q557E6", "name": "phospho-p-T309-RAD51", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10577605", "map_id": "Q54WD7", "name": "phospho-p-S317,S345-CHEK1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0279719", "map_id": "DDB_G0279719", "name": "phospho-p-S317,S345-CHEK1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10608453", "map_id": "none", "name": "BCDX2 complex stabilizes RAD51 filament", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10608435", "map_id": "none", "name": "3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54BU8", "map_id": "Q54BU8", "name": "BRCA2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293414", "map_id": "DDB_G0293414", "name": "BRCA2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q557E6", "map_id": "Q557E6", "name": "RAD51", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86IV6", "map_id": "Q86IV6", "name": "DNA2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274777", "map_id": "DDB_G0274777", "name": "DNA2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Q57", "map_id": "Q54Q57", "name": "RMI1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284153", "map_id": "DDB_G0284153", "name": "RMI1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DM3", "map_id": "Q54DM3", "name": "BLM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292130", "map_id": "DDB_G0292130", "name": "BLM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GC4", "map_id": "Q54GC4", "name": "RMI2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290275", "map_id": "DDB_G0290275", "name": "RMI2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T2T7", "map_id": "Q8T2T7", "name": "top3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275257", "map_id": "DDB_G0275257", "name": "top3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ED2", "map_id": "Q54ED2", "name": "exo1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291570", "map_id": "DDB_G0291570", "name": "exo1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LI7", "map_id": "Q54LI7", "name": "phospho-p-S990,Ac-K1249-BRIP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286621", "map_id": "DDB_G0286621", "name": "phospho-p-S990,Ac-K1249-BRIP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10608449", "map_id": "none", "name": "BCDX2 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q1ZXF0", "map_id": "Q1ZXF0", "name": "rad51d", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285287", "map_id": "DDB_G0285287", "name": "rad51d", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PJ7", "map_id": "Q54PJ7", "name": "rad51c", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284507", "map_id": "DDB_G0284507", "name": "rad51c", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54G98", "map_id": "Q54G98", "name": "XRCC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290297", "map_id": "DDB_G0290297", "name": "XRCC2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10608451", "map_id": "none", "name": "3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:BCDX2 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10608379", "map_id": "none", "name": "CHEK1 phosphorylates BRCA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10608374", "map_id": "Q54BU8", "name": "BRCA2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10608377", "map_id": "Q54BU8", "name": "phospho-p-T3387-BRCA2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10608473", "map_id": "none", "name": "Long-range resection of DNA DSBs by EXO1 or DNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10608468", "map_id": "none", "name": "3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10608470", "map_id": "none", "name": "3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10581776", "map_id": "none", "name": "Formation of RAD52 heptameric ring structure complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10581772", "map_id": "Q55E38", "name": "RAD52", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0269406", "map_id": "DDB_G0269406", "name": "RAD52", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10581774", "map_id": "none", "name": "RAD52 heptamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55E38", "map_id": "Q55E38", "name": "RAD52", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10612584", "map_id": "none", "name": "FANCD2 binds FANCI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10612575", "map_id": "Q55F81", "name": "FANCD2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0268216", "map_id": "DDB_G0268216", "name": "FANCD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10612580", "map_id": "Q54BR4", "name": "FANCI", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0293476", "map_id": "DDB_G0293476", "name": "FANCI", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10612582", "map_id": "none", "name": "FANCD2:FANCI", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54BR4", "map_id": "Q54BR4", "name": "FANCI", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55F81", "map_id": "Q55F81", "name": "FANCD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10582999", "map_id": "none", "name": "cAMP induces dissociation of inactive PKA tetramers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10582995", "map_id": "none", "name": "PKA tetramer:4xcAMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P34099", "map_id": "P34099", "name": "pkaC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283907", "map_id": "DDB_G0283907", "name": "pkaC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34100", "map_id": "P34100", "name": "pkaD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277145", "map_id": "DDB_G0277145", "name": "pkaD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34103", "map_id": "P34103", "name": "pkgD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284029", "map_id": "DDB_G0284029", "name": "pkgD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P05987", "map_id": "P05987", "name": "pkaR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279413", "map_id": "DDB_G0279413", "name": "pkaR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MM62", "map_id": "Q8MM62", "name": "pdeE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276027", "map_id": "DDB_G0276027", "name": "pdeE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_30389", "map_id": "CHEBI:17489", "name": "cAMP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10582991", "map_id": "none", "name": "Homologues of PRKACA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10582997", "map_id": "none", "name": "cAMP:PKA regulatory subunit", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10611073", "map_id": "none", "name": "UCHL3, SENP8 cleave NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10611064", "map_id": "none", "name": "UCHL3,SENP8:NEDD8(1-88)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54T48", "map_id": "Q54T48", "name": "uch1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282007", "map_id": "DDB_G0282007", "name": "uch1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XV3", "map_id": "Q54XV3", "name": "nedd8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278711", "map_id": "DDB_G0278711", "name": "nedd8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10611070", "map_id": "Q54XV3", "name": "nedd8", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10611068", "map_id": "none", "name": "UCHL3,SENP8:NEDD8", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10623717", "map_id": "none", "name": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10623697", "map_id": "none", "name": "NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54TI6", "map_id": "Q54TI6", "name": "ube2m", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281725", "map_id": "DDB_G0281725", "name": "ube2m", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GP1", "map_id": "Q54GP1", "name": "DCUN1D1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290025", "map_id": "DDB_G0290025", "name": "DCUN1D1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RP0", "map_id": "Q54RP0", "name": "agtA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283005", "map_id": "DDB_G0283005", "name": "agtA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KWS8", "map_id": "Q7KWS8", "name": "BTRC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276283", "map_id": "DDB_G0276283", "name": "BTRC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P42524", "map_id": "P42524", "name": "cycB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275493", "map_id": "DDB_G0275493", "name": "cycB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T2F2", "map_id": "Q8T2F2", "name": "CCNF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277439", "map_id": "DDB_G0277439", "name": "CCNF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54UQ3", "map_id": "Q54UQ3", "name": "FBXW4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280895", "map_id": "DDB_G0280895", "name": "FBXW4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55G05", "map_id": "Q55G05", "name": "FBXL3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290985", "map_id": "DDB_G0290985", "name": "FBXL3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FA1", "map_id": "Q54FA1", "name": "FBXL3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PH6", "map_id": "Q54PH6", "name": "FBXL3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54F90", "map_id": "Q54F90", "name": "FBXW7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291003", "map_id": "DDB_G0291003", "name": "FBXW7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DF3", "map_id": "Q54DF3", "name": "FBXO10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292302", "map_id": "DDB_G0292302", "name": "FBXO10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54N86", "map_id": "Q54N86", "name": "FBXW9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285445", "map_id": "DDB_G0285445", "name": "FBXW9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54K33", "map_id": "Q54K33", "name": "rbx1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287629", "map_id": "DDB_G0287629", "name": "rbx1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P52285", "map_id": "P52285", "name": "fpaA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269230", "map_id": "DDB_G0269230", "name": "fpaA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q557E4", "map_id": "Q557E4", "name": "fpaB-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273251", "map_id": "DDB_G0273251", "name": "fpaB-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O60999", "map_id": "O60999", "name": "culA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291972", "map_id": "DDB_G0291972", "name": "culA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DR0", "map_id": "Q54DR0", "name": "commd1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292074", "map_id": "DDB_G0292074", "name": "commd1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MP2", "map_id": "Q54MP2", "name": "CCDC22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285813", "map_id": "DDB_G0285813", "name": "CCDC22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10623709", "map_id": "none", "name": "NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10623518", "map_id": "Q54TI6", "name": "ube2m", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10623715", "map_id": "none", "name": "CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10624069", "map_id": "none", "name": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10623818", "map_id": "none", "name": "NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54CS2", "map_id": "Q54CS2", "name": "culD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292794", "map_id": "DDB_G0292794", "name": "culD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B0M0P5", "map_id": "B0M0P5", "name": "repE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286013", "map_id": "DDB_G0286013", "name": "repE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54E28", "map_id": "Q54E28", "name": "DCAF11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291832", "map_id": "DDB_G0291832", "name": "DCAF11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q551N8", "map_id": "Q551N8", "name": "ERCC8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276481", "map_id": "DDB_G0276481", "name": "ERCC8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MK9", "map_id": "Q54MK9", "name": "DCAF6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285955", "map_id": "DDB_G0285955", "name": "DCAF6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KWL3", "map_id": "Q7KWL3", "name": "wdsof1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276815", "map_id": "DDB_G0276815", "name": "wdsof1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IY4", "map_id": "Q54IY4", "name": "RFWD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288453", "map_id": "DDB_G0288453", "name": "RFWD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SD4", "map_id": "Q54SD4", "name": "rbbD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282529", "map_id": "DDB_G0282529", "name": "rbbD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QW6", "map_id": "Q54QW6", "name": "RBBP7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283565", "map_id": "DDB_G0283565", "name": "RBBP7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KL5", "map_id": "Q54KL5", "name": "wdr5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287273", "map_id": "DDB_G0287273", "name": "wdr5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DC7", "map_id": "Q55DC7", "name": "WDR5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290127", "map_id": "DDB_G0290127", "name": "WDR5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GJ0", "map_id": "Q54GJ0", "name": "WDR5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54M93", "map_id": "Q54M93", "name": "WDR5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VP0", "map_id": "Q54VP0", "name": "WDR5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54K75", "map_id": "Q54K75", "name": "WDR5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DE3", "map_id": "Q55DE3", "name": "DCAF5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269686", "map_id": "DDB_G0269686", "name": "DCAF5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MH6", "map_id": "Q54MH6", "name": "rbbE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285847", "map_id": "DDB_G0285847", "name": "rbbE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q552R1", "map_id": "Q552R1", "name": "wdr68", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275925", "map_id": "DDB_G0275925", "name": "wdr68", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10624064", "map_id": "Q54XV3", "name": "nedd8", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10624066", "map_id": "none", "name": "CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10611193", "map_id": "none", "name": "COP9 signalosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54PF3", "map_id": "Q54PF3", "name": "csn5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284597", "map_id": "DDB_G0284597", "name": "csn5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QX3", "map_id": "Q54QX3", "name": "csn1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283587", "map_id": "DDB_G0283587", "name": "csn1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HL6", "map_id": "Q54HL6", "name": "csn2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289361", "map_id": "DDB_G0289361", "name": "csn2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BD5", "map_id": "Q55BD5", "name": "csn7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271282", "map_id": "DDB_G0271282", "name": "csn7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54E53", "map_id": "Q54E53", "name": "csn3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291848", "map_id": "DDB_G0291848", "name": "csn3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54C92", "map_id": "Q54C92", "name": "csn6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293180", "map_id": "DDB_G0293180", "name": "csn6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q75K24", "map_id": "Q75K24", "name": "csn8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275471", "map_id": "DDB_G0275471", "name": "csn8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54B82", "map_id": "Q54B82", "name": "csn4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293844", "map_id": "DDB_G0293844", "name": "csn4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10623720", "map_id": "none", "name": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10623695", "map_id": "none", "name": "CRL1 E3 ubiquitin ligase:COMMDs:CCDC22", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10623652", "map_id": "none", "name": "DCUN1Ds", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10623542", "map_id": "none", "name": "NEDD8-AcM-UBE2M", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10623656", "map_id": "none", "name": "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10623629", "map_id": "none", "name": "CRL5 E3 ubiquitin ligase:COMMDs:CCDC22", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XZJ3", "map_id": "Q9XZJ3", "name": "culB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267384", "map_id": "DDB_G0267384", "name": "culB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XF7", "map_id": "Q54XF7", "name": "culE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278991", "map_id": "DDB_G0278991", "name": "culE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54J43", "map_id": "Q54J43", "name": "cnrM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288307", "map_id": "DDB_G0288307", "name": "cnrM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54X83", "map_id": "Q54X83", "name": "ASB3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279139", "map_id": "DDB_G0279139", "name": "ASB3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Q05", "map_id": "Q54Q05", "name": "tceb1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284201", "map_id": "DDB_G0284201", "name": "tceb1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10623576", "map_id": "none", "name": "NEDD8-AcM-UBE2F", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54J12", "map_id": "Q54J12", "name": "UBE2F", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288697", "map_id": "DDB_G0288697", "name": "UBE2F", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94490", "map_id": "Q94490", "name": "ubcB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284865", "map_id": "DDB_G0284865", "name": "ubcB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IK3", "map_id": "Q54IK3", "name": "UBE2F", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10623654", "map_id": "none", "name": "NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10623977", "map_id": "none", "name": "CAND1 binds cytosolic CRL E3 ubiquitin ligases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10623973", "map_id": "none", "name": "CRL E3 ubiquitin ligases", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54PM1", "map_id": "Q54PM1", "name": "LRR1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284461", "map_id": "DDB_G0284461", "name": "LRR1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LV9", "map_id": "Q54LV9", "name": "BTBD6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286387", "map_id": "DDB_G0286387", "name": "BTBD6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BF8", "map_id": "Q55BF8", "name": "KBTBD8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271372", "map_id": "DDB_G0271372", "name": "KBTBD8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DL2", "map_id": "Q54DL2", "name": "KCTD6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292144", "map_id": "DDB_G0292144", "name": "KCTD6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54D84", "map_id": "Q54D84", "name": "triA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292436", "map_id": "DDB_G0292436", "name": "triA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86AD8", "map_id": "Q86AD8", "name": "DG1106", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271500", "map_id": "DDB_G0271500", "name": "DG1106", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XA6", "map_id": "Q54XA6", "name": "KLHL42", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279093", "map_id": "DDB_G0279093", "name": "KLHL42", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NZ5", "map_id": "Q54NZ5", "name": "culC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10611216", "map_id": "Q86KD1", "name": "cand1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0274167", "map_id": "DDB_G0274167", "name": "cand1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10623975", "map_id": "none", "name": "CRL E3 ubiquitin ligase:CAND1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86KD1", "map_id": "Q86KD1", "name": "cand1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10623983", "map_id": "none", "name": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10623979", "map_id": "Q86KD1", "name": "cand1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10623754", "map_id": "none", "name": "RBX1:CUL4:DDB1:DCAFs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10623981", "map_id": "none", "name": "CRL4 E3 ubiquitin ligase:CAND1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10623823", "map_id": "none", "name": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10623726", "map_id": "none", "name": "NEDD8-AcM-UBE2M", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10623780", "map_id": "none", "name": "CRL4 E3 ubiquitin ligase:COMMDs:CCDC22", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10623792", "map_id": "none", "name": "DCUN1D1,2,4,5", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10623794", "map_id": "none", "name": "NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10623821", "map_id": "none", "name": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10623796", "map_id": "Q54TI6", "name": "ube2m", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10623985", "map_id": "none", "name": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10623778", "map_id": "none", "name": "COMMDs:CCDC22", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10624084", "map_id": "none", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10624075", "map_id": "none", "name": "RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10624080", "map_id": "Q55BU7", "name": "ubxd7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0270358", "map_id": "DDB_G0270358", "name": "ubxd7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10624082", "map_id": "none", "name": "RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55BU7", "map_id": "Q55BU7", "name": "ubxd7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10624090", "map_id": "none", "name": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10623713", "map_id": "Q54GP1", "name": "MyrG-DCUN1D3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10623515", "map_id": "none", "name": "Release of mature NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10611066", "map_id": "Q54XV3", "name": "nedd8", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10610849", "map_id": "Q54T48", "name": "uch1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10623993", "map_id": "none", "name": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10623627", "map_id": "none", "name": "COMMDs:CCDC22", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10623991", "map_id": "none", "name": "CRL E3 ubiquitin ligase:COMMDs:CCDC22", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10624062", "map_id": "none", "name": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10624049", "map_id": "none", "name": "NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10624059", "map_id": "none", "name": "CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10619704", "map_id": "none", "name": "COP9", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10623679", "map_id": "none", "name": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10623676", "map_id": "none", "name": "NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10623557", "map_id": "none", "name": "Homologues of AcM-UBE2F", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10585332", "map_id": "none", "name": "Association of Cdh1 with the APC/C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10577382", "map_id": "Q54KM3", "name": "cdh1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0287259", "map_id": "DDB_G0287259", "name": "cdh1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10577377", "map_id": "none", "name": "phosphorylated anaphase promoting complex (APC/C)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54XS6", "map_id": "Q54XS6", "name": "ube2c", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278775", "map_id": "DDB_G0278775", "name": "ube2c", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VV5", "map_id": "Q54VV5", "name": "anapc5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280113", "map_id": "DDB_G0280113", "name": "anapc5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXE6", "map_id": "Q1ZXE6", "name": "anapc6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286233", "map_id": "DDB_G0286233", "name": "anapc6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NC6", "map_id": "Q54NC6", "name": "anapc1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285349", "map_id": "DDB_G0285349", "name": "anapc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YA9", "map_id": "Q54YA9", "name": "ANAPC7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278327", "map_id": "DDB_G0278327", "name": "ANAPC7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55ER5", "map_id": "Q55ER5", "name": "anapc10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268992", "map_id": "DDB_G0268992", "name": "anapc10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86B11", "map_id": "Q86B11", "name": "anapc8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272775", "map_id": "DDB_G0272775", "name": "anapc8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q551S9", "map_id": "Q551S9", "name": "anapc2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276377", "map_id": "DDB_G0276377", "name": "anapc2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54C30", "map_id": "Q54C30", "name": "cdc26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293230", "map_id": "DDB_G0293230", "name": "cdc26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54L48", "map_id": "Q54L48", "name": "anapc11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286909", "map_id": "DDB_G0286909", "name": "anapc11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54J83", "map_id": "Q54J83", "name": "anapc3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288223", "map_id": "DDB_G0288223", "name": "anapc3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NI1", "map_id": "Q54NI1", "name": "anapc4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285223", "map_id": "DDB_G0285223", "name": "anapc4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54I43", "map_id": "Q54I43", "name": "ube2s", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289021", "map_id": "DDB_G0289021", "name": "ube2s", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10577384", "map_id": "none", "name": "phospho-APC/C:Cdh1 complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54KM3", "map_id": "Q54KM3", "name": "cdh1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10585450", "map_id": "none", "name": "Dissociation of Cdc20 from APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10585386", "map_id": "none", "name": "CDC20:p-APC/C", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54MZ3", "map_id": "Q54MZ3", "name": "cdc20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285601", "map_id": "DDB_G0285601", "name": "cdc20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10583643", "map_id": "Q54MZ3", "name": "cdc20", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10587270", "map_id": "none", "name": "AKT can phosphorylate RSK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10587243", "map_id": "Q8MYF1", "name": "RPS6KB2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10587247", "map_id": "Q8MYF1", "name": "phospho-p-S15,S356-RPS6KB2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10603208", "map_id": "none", "name": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10585338", "map_id": "none", "name": "Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10585340", "map_id": "none", "name": "Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10603227", "map_id": "none", "name": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10603218", "map_id": "none", "name": "EHMT1:EHMT2:Cdh1:p-APC/C", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10576865", "map_id": "none", "name": "Ub", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10603224", "map_id": "none", "name": "Ub-EHMT1:Ub-EHMT2:Cdh1:p-APC/C", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10603210", "map_id": "none", "name": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10585336", "map_id": "none", "name": "Cdh1:phospho-APC/C complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10576705", "map_id": "none", "name": "CCNA:p-T160-CDK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10598257", "map_id": "none", "name": "ETA is phosphorylated to PETA by CHK/ETNK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1498751", "map_id": "CHEBI:16000", "name": "ETA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_428686", "map_id": "CHEBI:17553", "name": "PETA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10598254", "map_id": "none", "name": "CHK/ETNK", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q554D8", "map_id": "Q554D8", "name": "etnkB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275265", "map_id": "DDB_G0275265", "name": "etnkB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q869T9", "map_id": "Q869T9", "name": "etnkA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274955", "map_id": "DDB_G0274955", "name": "etnkA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598075", "map_id": "none", "name": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1500603", "map_id": "CHEBI:16732", "name": "CDP-ETA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1500596", "map_id": "CHEBI:17815", "name": "DAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_1500581", "map_id": "CHEBI:16038", "name": "PE", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10598072", "map_id": "none", "name": "CEPT1/EPT1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q8T2Q6", "map_id": "Q8T2Q6", "name": "captD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275235", "map_id": "DDB_G0275235", "name": "captD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XM0", "map_id": "Q54XM0", "name": "captB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278947", "map_id": "DDB_G0278947", "name": "captB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q550W1", "map_id": "Q550W1", "name": "captC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276763", "map_id": "DDB_G0276763", "name": "captC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AQ3", "map_id": "Q55AQ3", "name": "captA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271794", "map_id": "DDB_G0271794", "name": "captA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29926", "map_id": "CHEBI:18420", "name": "Mg2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_266099", "map_id": "CHEBI:29035", "name": "Mn2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10598234", "map_id": "none", "name": "PA is dephosphorylated to DAG by LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_426755", "map_id": "CHEBI:16337", "name": "PA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10598231", "map_id": "none", "name": "LPIN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10598223", "map_id": "none", "name": "PETA and CTP are condensed to CDP-ETA by PCY2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_110614", "map_id": "CHEBI:17677", "name": "CTP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10598220", "map_id": "none", "name": "PCYT2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q55BZ4", "map_id": "Q55BZ4", "name": "pctA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270298", "map_id": "DDB_G0270298", "name": "pctA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10583607", "map_id": "none", "name": "MAOA:FAD oxidatively deaminates of 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_209914", "map_id": "CHEBI:28790", "name": "5HT", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_500604", "map_id": "CHEBI:50157", "name": "5HIALD", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29408", "map_id": "CHEBI:16240", "name": "H2O2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10583604", "map_id": "none", "name": "MAOA:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q54RP5", "map_id": "Q54RP5", "name": "MAOA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282999", "map_id": "DDB_G0282999", "name": "MAOA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10589900", "map_id": "none", "name": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113526", "map_id": "CHEBI:57540", "name": "NAD+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_380598", "map_id": "CHEBI:50157", "name": "HIALD", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_380593", "map_id": "CHEBI:27823", "name": "HIAA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_29362", "map_id": "CHEBI:57945", "name": "NADH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10578724", "map_id": "none", "name": "ALDH2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54FY3", "map_id": "Q54FY3", "name": "hydA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290479", "map_id": "DDB_G0290479", "name": "hydA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10583105", "map_id": "none", "name": "Inactivation of PLC beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10582955", "map_id": "none", "name": "Activated PLC beta 1/4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q55EP5", "map_id": "Q55EP5", "name": "gpaJ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268802", "map_id": "DDB_G0268802", "name": "gpaJ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T130", "map_id": "Q8T130", "name": "gpaK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276343", "map_id": "DDB_G0276343", "name": "gpaK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P16051", "map_id": "P16051", "name": "gpaB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276267", "map_id": "DDB_G0276267", "name": "gpaB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P16894", "map_id": "P16894", "name": "gpaA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283349", "map_id": "DDB_G0283349", "name": "gpaA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34042", "map_id": "P34042", "name": "gpaD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285425", "map_id": "DDB_G0285425", "name": "gpaD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34043", "map_id": "P34043", "name": "gpaE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286185", "map_id": "DDB_G0286185", "name": "gpaE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34044", "map_id": "P34044", "name": "gpaF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283151", "map_id": "DDB_G0283151", "name": "gpaF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34045", "map_id": "P34045", "name": "gpaG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276455", "map_id": "DDB_G0276455", "name": "gpaG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34046", "map_id": "P34046", "name": "gpaH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284469", "map_id": "DDB_G0284469", "name": "gpaH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KV6", "map_id": "Q54KV6", "name": "gpaC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287031", "map_id": "DDB_G0287031", "name": "gpaC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54R41", "map_id": "Q54R41", "name": "gpaI", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283419", "map_id": "DDB_G0283419", "name": "gpaI", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54UG5", "map_id": "Q54UG5", "name": "gbqA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280965", "map_id": "DDB_G0280965", "name": "gbqA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VG1", "map_id": "Q54VG1", "name": "gpaL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280351", "map_id": "DDB_G0280351", "name": "gpaL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q02158", "map_id": "Q02158", "name": "plc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292736", "map_id": "DDB_G0292736", "name": "plc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10583103", "map_id": "none", "name": "G-protein alpha:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10582859", "map_id": "Q02158", "name": "plc", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10592511", "map_id": "none", "name": "CaMKK autophosphorylates in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10592503", "map_id": "none", "name": "CaMKK:CALM1:4xCa2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55CW1", "map_id": "Q55CW1", "name": "phospho-samkD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270680", "map_id": "DDB_G0270680", "name": "phospho-samkD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10592508", "map_id": "none", "name": "p-CaMKK:CALM1:4xCa2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10583076", "map_id": "none", "name": "cAMP hydrolysis by Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10583073", "map_id": "none", "name": "activated PDE1 dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q23917", "map_id": "Q23917", "name": "phospho-regA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284331", "map_id": "DDB_G0284331", "name": "phospho-regA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86H13", "map_id": "Q86H13", "name": "phospho-Pde4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289121", "map_id": "DDB_G0289121", "name": "phospho-Pde4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10583078", "map_id": "none", "name": "Calmodulin activates Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10583042", "map_id": "none", "name": "CALM1:4xCa2+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10583044", "map_id": "none", "name": "Adenylate cyclase produces cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10583022", "map_id": "none", "name": "Adenylate cyclase (Mg2+ cofactor)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q03100", "map_id": "Q03100", "name": "acaA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281545", "map_id": "DDB_G0281545", "name": "acaA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10623546", "map_id": "none", "name": "cAMP binds PKA tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10582993", "map_id": "none", "name": "PKA tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10582958", "map_id": "none", "name": "PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_179856", "map_id": "CHEBI:18348", "name": "PI(4,5)P2", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_114520", "map_id": "CHEBI:16595", "name": "I(1,4,5)P3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_112275", "map_id": "CHEBI:18035", "name": "DAGs", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10577793", "map_id": "none", "name": "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29728", "map_id": "CHEBI:58272", "name": "3PG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29800", "map_id": "CHEBI:57604", "name": "1,3BPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10577790", "map_id": "none", "name": "PGK complexes", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9GPM4", "map_id": "Q9GPM4", "name": "pgkA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287595", "map_id": "DDB_G0287595", "name": "pgkA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10589604", "map_id": "none", "name": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_113544", "map_id": "CHEBI:30797", "name": "MAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113548", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_198498", "map_id": "CHEBI:30797", "name": "MAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10589601", "map_id": "Q54PY7", "name": "ucpC", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0284225", "map_id": "DDB_G0284225", "name": "ucpC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586982", "map_id": "none", "name": "malate + NAD+ <=> oxaloacetate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29360", "map_id": "CHEBI:57540", "name": "NAD+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_73473", "map_id": "CHEBI:57945", "name": "NADH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10586979", "map_id": "none", "name": "malate dehydrogenase 1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54GE6", "map_id": "Q54GE6", "name": "mdhA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290207", "map_id": "DDB_G0290207", "name": "mdhA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10577773", "map_id": "none", "name": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30014", "map_id": "CHEBI:32966", "name": "F1,6PP", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29512", "map_id": "CHEBI:57634", "name": "Fru(6)P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10577770", "map_id": "none", "name": "FBP tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q6RYT0", "map_id": "Q6RYT0", "name": "fbp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270836", "map_id": "DDB_G0270836", "name": "fbp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10589548", "map_id": "none", "name": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29404", "map_id": "CHEBI:29985", "name": "L-Glu", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_113553", "map_id": "CHEBI:29991", "name": "L-Asp", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_29448", "map_id": "CHEBI:29991", "name": "L-Asp", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_113552", "map_id": "CHEBI:29985", "name": "L-Glu", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10589543", "map_id": "Q54RB9", "name": "mcfO", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0283329", "map_id": "DDB_G0283329", "name": "mcfO", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10589775", "map_id": "none", "name": "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_113594", "map_id": "CHEBI:16810", "name": "2OG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_29406", "map_id": "CHEBI:16810", "name": "2OG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10586969", "map_id": "none", "name": "SLC25A11 homodimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q54PY7", "map_id": "Q54PY7", "name": "ucpC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10577775", "map_id": "none", "name": "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29578", "map_id": "CHEBI:59776", "name": "GA3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_75970", "map_id": "CHEBI:57642", "name": "DHAP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10577742", "map_id": "none", "name": "TPI1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q869R8", "map_id": "Q869R8", "name": "tpiA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274471", "map_id": "DDB_G0274471", "name": "tpiA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10577777", "map_id": "none", "name": "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10577732", "map_id": "none", "name": "GAPDH tetramers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q94469", "map_id": "Q94469", "name": "gpdA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275153", "map_id": "DDB_G0275153", "name": "gpdA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578553", "map_id": "none", "name": "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30485", "map_id": "CHEBI:58289", "name": "2PG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10578550", "map_id": "none", "name": "PGAM dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54NE6", "map_id": "Q54NE6", "name": "gpmA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285311", "map_id": "DDB_G0285311", "name": "gpmA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10577757", "map_id": "none", "name": "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30537", "map_id": "CHEBI:58225", "name": "G6P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10577752", "map_id": "none", "name": "GPI dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q5V9E9", "map_id": "Q5V9E9", "name": "gpi", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283673", "map_id": "DDB_G0283673", "name": "gpi", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586972", "map_id": "none", "name": "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10577628", "map_id": "none", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29492", "map_id": "CHEBI:58702", "name": "PEP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10577625", "map_id": "Q869Z4", "name": "pck2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0271904", "map_id": "DDB_G0271904", "name": "pck2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10577820", "map_id": "none", "name": "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10577817", "map_id": "none", "name": "enolase dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54RK5", "map_id": "Q54RK5", "name": "enoA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283137", "map_id": "DDB_G0283137", "name": "enoA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55F83", "map_id": "Q55F83", "name": "enoB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268214", "map_id": "DDB_G0268214", "name": "enoB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578556", "map_id": "none", "name": "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10577690", "map_id": "none", "name": "ALDOB tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86A67", "map_id": "Q86A67", "name": "fba", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274375", "map_id": "DDB_G0274375", "name": "fba", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10589599", "map_id": "none", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113573", "map_id": "CHEBI:15996", "name": "GTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113587", "map_id": "CHEBI:30744", "name": "OAA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_372364", "map_id": "CHEBI:58702", "name": "PEP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113525", "map_id": "CHEBI:17552", "name": "GDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_29376", "map_id": "CHEBI:16526", "name": "CO2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10589596", "map_id": "Q869Z4", "name": "pck2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10577886", "map_id": "none", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10577869", "map_id": "none", "name": "GOT2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q55F21", "map_id": "Q55F21", "name": "aatA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268664", "map_id": "DDB_G0268664", "name": "aatA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10602325", "map_id": "none", "name": "p-S407-STAT6 is phosphorylated at Tyr641", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602323", "map_id": "none", "name": "Homologues of p-S407-STAT6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10602295", "map_id": "none", "name": "Homologues of p-S407,Y641-STAT6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10602311", "map_id": "none", "name": "p-S407,Y641-STAT6 dimer migrates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602297", "map_id": "none", "name": "p-S407,Y641-STAT6 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10602309", "map_id": "none", "name": "p-S407,Y641-STAT6 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10602313", "map_id": "none", "name": "p-S407,Y641-STAT6 is dimerized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10597394", "map_id": "none", "name": "Activation of TWIK-related K+ channel (TREK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_29804", "map_id": "CHEBI:29103", "name": "K+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_74126", "map_id": "CHEBI:29103", "name": "K+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10597391", "map_id": "none", "name": "TREK homodimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q86K40", "map_id": "Q86K40", "name": "KCNK15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277255", "map_id": "DDB_G0277255", "name": "KCNK15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T268", "map_id": "Q8T268", "name": "KCNK15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598007", "map_id": "none", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[6]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_426925", "map_id": "CHEBI:16110", "name": "PC", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_1524028", "map_id": "CHEBI:17504", "name": "1-acyl LPC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_1524021", "map_id": "CHEBI:57560", "name": "LCFA(-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10598004", "map_id": "Q54QX6", "name": "PNPLA8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0283551", "map_id": "DDB_G0283551", "name": "PNPLA8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10597944", "map_id": "none", "name": "1-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1500578", "map_id": "CHEBI:17984", "name": "acyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10597927", "map_id": "none", "name": "LPCAT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54XX2", "map_id": "Q54XX2", "name": "MBOAT7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278541", "map_id": "DDB_G0278541", "name": "MBOAT7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54X10", "map_id": "Q54X10", "name": "LPCAT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279277", "map_id": "DDB_G0279277", "name": "LPCAT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10597930", "map_id": "none", "name": "2-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_975614", "map_id": "CHEBI:16728", "name": "2-acyl LPC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10621983", "map_id": "none", "name": "THEM86B hydrolyses PMCHO, PMETAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8874447", "map_id": "none", "name": "PMCHO, PMETAM", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "CHEBI:17810", "map_id": "CHEBI:17810", "name": "CHEBI:17810", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17476", "map_id": "CHEBI:17476", "name": "CHEBI:17476", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8874450", "map_id": "none", "name": "GPCHO, GPETAM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "CHEBI:36313", "map_id": "CHEBI:36313", "name": "CHEBI:36313", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:36314", "map_id": "CHEBI:36314", "name": "CHEBI:36314", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5696116", "map_id": "CHEBI:35746", "name": "fatty aldehyde", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10621980", "map_id": "Q86H31", "name": "tmem86", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0275665", "map_id": "DDB_G0275665", "name": "tmem86", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598014", "map_id": "none", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[5]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10597959", "map_id": "Q54PS7", "name": "plbD", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0284449", "map_id": "DDB_G0284449", "name": "plbD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10582832", "map_id": "none", "name": "Cleavage of the 3'-end of the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10582828", "map_id": "none", "name": "Capped Intronless Histone pre-mRNA:CBC:ZFP100 Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55A45", "map_id": "Q55A45", "name": "snrpb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272320", "map_id": "DDB_G0272320", "name": "snrpb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C7G054", "map_id": "C7G054", "name": "snrpE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0302414", "map_id": "DDB_G0302414", "name": "snrpE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86L45", "map_id": "Q86L45", "name": "snrpD3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273003", "map_id": "DDB_G0273003", "name": "snrpD3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XP2", "map_id": "Q54XP2", "name": "snrpf", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278821", "map_id": "DDB_G0278821", "name": "snrpf", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54F84", "map_id": "Q54F84", "name": "LSM10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291015", "map_id": "DDB_G0291015", "name": "LSM10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RX0", "map_id": "Q54RX0", "name": "snrpG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282863", "map_id": "DDB_G0282863", "name": "snrpG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55D17", "map_id": "Q55D17", "name": "ncbp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269814", "map_id": "DDB_G0269814", "name": "ncbp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KR9", "map_id": "Q54KR9", "name": "ncbp2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287197", "map_id": "DDB_G0287197", "name": "ncbp2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10582830", "map_id": "none", "name": "Mature intronless transcript derived Histone pre-mRNA:CBC complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10582465", "map_id": "none", "name": "U7 snRNP:ZNF473", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10582834", "map_id": "none", "name": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10582432", "map_id": "none", "name": "Capped Intronless Histone pre-mRNA:CBC complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10627229", "map_id": "none", "name": "DKC1 binds SHQ1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10627225", "map_id": "Q55EC4", "name": "SHQ1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0269304", "map_id": "DDB_G0269304", "name": "SHQ1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10584005", "map_id": "Q54T81", "name": "nola4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0281933", "map_id": "DDB_G0281933", "name": "nola4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10627227", "map_id": "none", "name": "DKC1:SHQ1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54T81", "map_id": "Q54T81", "name": "nola4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55EC4", "map_id": "Q55EC4", "name": "SHQ1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10600850", "map_id": "none", "name": "PLK1 hyperphosphorylates Condensin II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10600834", "map_id": "none", "name": "p-T210-PLK1:Phosphorylated Condensin II:Nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q86HN7", "map_id": "Q86HN7", "name": "phospho-PLK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274503", "map_id": "DDB_G0274503", "name": "phospho-PLK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q76NW2", "map_id": "Q76NW2", "name": "H4b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276863", "map_id": "DDB_G0276863", "name": "H4b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PK4", "map_id": "Q54PK4", "name": "smc2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284499", "map_id": "DDB_G0284499", "name": "smc2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ID6", "map_id": "Q54ID6", "name": "phospho-p-S-NCAPG2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288819", "map_id": "DDB_G0288819", "name": "phospho-p-S-NCAPG2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DZ9", "map_id": "Q54DZ9", "name": "phospho-p-S-NCAPH2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291894", "map_id": "DDB_G0291894", "name": "phospho-p-S-NCAPH2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LV0", "map_id": "Q54LV0", "name": "smc4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286403", "map_id": "DDB_G0286403", "name": "smc4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XY3", "map_id": "Q54XY3", "name": "phospho-p-T1415,S1419-NCAPD3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278701", "map_id": "DDB_G0278701", "name": "phospho-p-T1415,S1419-NCAPD3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10600847", "map_id": "none", "name": "Hyperphosphorylated Condensin II:Nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10600854", "map_id": "none", "name": "PLK1 binds phosphorylated condensin II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10600852", "map_id": "none", "name": "Phosphorylated Condensin II:Nucleosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10583697", "map_id": "Q86HN7", "name": "phospho-PLK", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10600826", "map_id": "none", "name": "Condensin II complex binds H4K20me1-containing nucleosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10600587", "map_id": "none", "name": "Condensin II", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10600624", "map_id": "none", "name": "Nucleosome with H3K4me2/3:H4K20me1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10600824", "map_id": "none", "name": "Condensin II:Nucleosome with H4K20me1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10600589", "map_id": "none", "name": "Condensin II:RB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10600637", "map_id": "none", "name": "PHF8 demethylates histone H4K20me1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10600630", "map_id": "none", "name": "PHF8:Nucleosome with H3K4me2/3:H4K20me1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_113671", "map_id": "CHEBI:16810", "name": "2OG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_113685", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10600634", "map_id": "none", "name": "PHF8:Nucleosome with H3K4me2/3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_29478", "map_id": "CHEBI:16842", "name": "CH2O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_159942", "map_id": "CHEBI:16526", "name": "CO2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_159939", "map_id": "CHEBI:30031", "name": "SUCCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10600591", "map_id": "none", "name": "RB1 binds condensin II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10577547", "map_id": "Q54FX2", "name": "rblA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10595203", "map_id": "none", "name": "Activation of Rap1 by membrane-associated GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10589459", "map_id": "none", "name": "RAP1:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P18613", "map_id": "P18613", "name": "rapA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291237", "map_id": "DDB_G0291237", "name": "rapA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BW0", "map_id": "Q55BW0", "name": "rapC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270340", "map_id": "DDB_G0270340", "name": "rapC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86L51", "map_id": "Q86L51", "name": "rapB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272857", "map_id": "DDB_G0272857", "name": "rapB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10589457", "map_id": "none", "name": "RAP1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10590642", "map_id": "none", "name": "Rap1 cAMP-GEFs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54TK8", "map_id": "Q54TK8", "name": "gefP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281573", "map_id": "DDB_G0281573", "name": "gefP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IS12", "map_id": "Q8IS12", "name": "gefN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275703", "map_id": "DDB_G0275703", "name": "gefN", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10589538", "map_id": "none", "name": "Activation of Rap1 by cytosolic GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10589535", "map_id": "none", "name": "CalDAG-GEFs:DAG:Ca2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_6797635", "map_id": "CHEBI:17815", "name": "1,2-DAG", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "Q55FD8", "map_id": "Q55FD8", "name": "phospho-gefV", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268578", "map_id": "DDB_G0268578", "name": "phospho-gefV", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GH9", "map_id": "Q55GH9", "name": "phospho-gefW", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267666", "map_id": "DDB_G0267666", "name": "phospho-gefW", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IS11", "map_id": "Q8IS11", "name": "phospho-gefO", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290267", "map_id": "DDB_G0290267", "name": "phospho-gefO", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IS14", "map_id": "Q8IS14", "name": "phospho-gefJ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277913", "map_id": "DDB_G0277913", "name": "phospho-gefJ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IS15", "map_id": "Q8IS15", "name": "phospho-gefI", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277915", "map_id": "DDB_G0277915", "name": "phospho-gefI", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IS16", "map_id": "Q8IS16", "name": "phospho-gefH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276963", "map_id": "DDB_G0276963", "name": "phospho-gefH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IS20", "map_id": "Q8IS20", "name": "phospho-gefC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282381", "map_id": "DDB_G0282381", "name": "phospho-gefC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IS21", "map_id": "Q8IS21", "name": "phospho-gefB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269222", "map_id": "DDB_G0269222", "name": "phospho-gefB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8SSQ0", "map_id": "Q8SSQ0", "name": "phospho-gefR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274605", "map_id": "DDB_G0274605", "name": "phospho-gefR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8SSW7", "map_id": "Q8SSW7", "name": "phospho-gefS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271868", "map_id": "DDB_G0271868", "name": "phospho-gefS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B0M0P8", "map_id": "B0M0P8", "name": "phospho-gefL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276371", "map_id": "DDB_G0276371", "name": "phospho-gefL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8ST25", "map_id": "Q8ST25", "name": "phospho-gefG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272032", "map_id": "DDB_G0272032", "name": "phospho-gefG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54C94", "map_id": "Q54C94", "name": "phospho-gefF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293006", "map_id": "DDB_G0293006", "name": "phospho-gefF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FF3", "map_id": "Q54FF3", "name": "phospho-gefK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290901", "map_id": "DDB_G0290901", "name": "phospho-gefK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54H95", "map_id": "Q54H95", "name": "phospho-p-T133-RASGRP3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289613", "map_id": "DDB_G0289613", "name": "phospho-p-T133-RASGRP3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PQ4", "map_id": "Q54PQ4", "name": "phospho-gefA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284329", "map_id": "DDB_G0284329", "name": "phospho-gefA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XL4", "map_id": "Q54XL4", "name": "phospho-p-T133-RASGRP3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10600085", "map_id": "none", "name": "Translocation of tetracosapentaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2046050", "map_id": "CHEBI:63546", "name": "TPA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_211579", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_5228339", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_2046055", "map_id": "CHEBI:63546", "name": "TPA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_211606", "map_id": "CHEBI:456216", "name": "ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10590195", "map_id": "Q8T8P3", "name": "abcD2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "false" }, { "id": "DDB_G0293194", "map_id": "DDB_G0293194", "name": "abcD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10600087", "map_id": "none", "name": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_2046066", "map_id": "CHEBI:15531", "name": "Malonyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2046042", "map_id": "CHEBI:15508", "name": "GLA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_113601", "map_id": "CHEBI:16474", "name": "NADPH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_113519", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_113564", "map_id": "CHEBI:18009", "name": "NADP+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_162743", "map_id": "CHEBI:15346", "name": "CoA-SH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_159751", "map_id": "CHEBI:16526", "name": "CO2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2046045", "map_id": "CHEBI:27979", "name": "DGL-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10600071", "map_id": "none", "name": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2046053", "map_id": "CHEBI:15514", "name": "AA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2046060", "map_id": "CHEBI:63544", "name": "DTA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10593964", "map_id": "none", "name": "Homologues of ELOVL2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10600089", "map_id": "none", "name": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_2046048", "map_id": "CHEBI:63548", "name": "TTA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10600091", "map_id": "none", "name": "Activation of linoleic acid to linoleoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2046044", "map_id": "CHEBI:17351", "name": "LINA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2046064", "map_id": "CHEBI:16027", "name": "adenosine 5'-monophosphate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_2046049", "map_id": "CHEBI:29888", "name": "PPi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_2046063", "map_id": "CHEBI:15530", "name": "LA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10600073", "map_id": "none", "name": "ACSL1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10599749", "map_id": "none", "name": "NDST1-4 N-deacetylates GlcNAc residues in heparan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_2022884", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10599746", "map_id": "none", "name": "Heparan(3)-PGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "Q55E77", "map_id": "Q55E77", "name": "HS(6)-AGRN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10599718", "map_id": "none", "name": "Heparan(4)-PGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_2022890", "map_id": "CHEBI:15366", "name": "CH3COO-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10599730", "map_id": "Q55GK8", "name": "kil1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "DDB_G0267630", "map_id": "DDB_G0267630", "name": "kil1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599739", "map_id": "none", "name": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_741440", "map_id": "CHEBI:17980", "name": "PAPS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10599725", "map_id": "none", "name": "HS(1)-PGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_742343", "map_id": "CHEBI:17985", "name": "PAP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10600141", "map_id": "none", "name": "HS3STs sulfate GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10599765", "map_id": "none", "name": "HS(3)-PGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10599772", "map_id": "none", "name": "HS(4)-PGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10600128", "map_id": "Q55GK8", "name": "kil1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10599821", "map_id": "none", "name": "Some HSPGs are secreted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10599787", "map_id": "none", "name": "HSPGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10599819", "map_id": "none", "name": "HSPGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10600126", "map_id": "none", "name": "HS3ST1 sulfates GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10600121", "map_id": "Q55GK8", "name": "kil1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10599661", "map_id": "none", "name": "XYLTs transfer Xyl to core protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10599635", "map_id": "none", "name": "GAG core proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_742361", "map_id": "CHEBI:16082", "name": "UDP-Xyl", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10599642", "map_id": "none", "name": "xylosyl-core proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_205687", "map_id": "CHEBI:17659", "name": "UDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10599658", "map_id": "none", "name": "XYLT1, XYLT2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q55F91", "map_id": "Q55F91", "name": "XYLT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269558", "map_id": "DDB_G0269558", "name": "XYLT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DR5", "map_id": "Q55DR5", "name": "XYLT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10600145", "map_id": "none", "name": "NAGLU hydrolyses heparan chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2090053", "map_id": "CHEBI:63645", "name": "Heparan chain(2)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1678743", "map_id": "CHEBI:17411", "name": "GlcNAc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2065212", "map_id": "CHEBI:63505", "name": "CS/HS precursor", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10599153", "map_id": "Q54DW5", "name": "NAGLU(59-743)", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "DDB_G0291998", "map_id": "DDB_G0291998", "name": "NAGLU(59-743)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10600147", "map_id": "none", "name": "GLB1 hydrolyses linker chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2090075", "map_id": "CHEBI:63503", "name": "linker chain(2)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1605637", "map_id": "CHEBI:28061", "name": "Gal", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2090063", "map_id": "CHEBI:15936", "name": "D-xylose", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10598338", "map_id": "Q54GE1", "name": "glb1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "DDB_G0290217", "map_id": "DDB_G0290217", "name": "glb1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10600149", "map_id": "none", "name": "HGSNAT oligomer acetylates Heparan chain(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_2090045", "map_id": "CHEBI:63811", "name": "Heparan chain(1)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10599125", "map_id": "none", "name": "HGSNAT oligomer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "Q54LX9", "map_id": "Q54LX9", "name": "HGSNAT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286315", "map_id": "DDB_G0286315", "name": "HGSNAT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599156", "map_id": "none", "name": "NAGLU hydrolyses Heparan sulfate chain(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2090069", "map_id": "CHEBI:63807", "name": "Heparan sulfate chain(4)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2090080", "map_id": "CHEBI:63808", "name": "Heparan sulfate chain(5)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10599751", "map_id": "none", "name": "HS-GAGs translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10599134", "map_id": "none", "name": "HS/HPIN-PGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10598515", "map_id": "none", "name": "HS/HPIN-PGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10599128", "map_id": "none", "name": "HGSNAT oligomer acetylates Heparan sulfate chain(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_2090040", "map_id": "CHEBI:63806", "name": "Heparan sulfate chain(3)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10599148", "map_id": "none", "name": "IDUA hydrolyses Heparan sulfate chain(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2090033", "map_id": "CHEBI:63666", "name": "Heparan sulfate chain(1)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2090072", "map_id": "CHEBI:63805", "name": "Heparan sulfate chain(2)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1678617", "map_id": "CHEBI:28481", "name": "aldehydo-L-iduronic acid", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10599145", "map_id": "Q54J53", "name": "IDUA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "DDB_G0288289", "map_id": "DDB_G0288289", "name": "IDUA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10600143", "map_id": "none", "name": "IDUA hydrolyses Heparan sulfate chain(6)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2090055", "map_id": "CHEBI:63809", "name": "Heparan sulfate chain(6)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2090070", "map_id": "CHEBI:63810", "name": "Heparan sulfate chain(7)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10593201", "map_id": "none", "name": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10577037", "map_id": "none", "name": "Ub", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10584754", "map_id": "none", "name": "K63polyUb", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10593152", "map_id": "none", "name": "p-IRAK2:K63-linked pUb oligo-TRAF6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10617650", "map_id": "none", "name": "NSF and SNAPs bind cis-SNARE at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10611694", "map_id": "none", "name": "NSF hexamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q75JI3", "map_id": "Q75JI3", "name": "nsfA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276153", "map_id": "DDB_G0276153", "name": "nsfA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10611703", "map_id": "none", "name": "SNAPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54NP6", "map_id": "Q54NP6", "name": "snpA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285111", "map_id": "DDB_G0285111", "name": "snpA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10617648", "map_id": "none", "name": "SEC22B:STX18:USE1L:BNIP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q55CR0", "map_id": "Q55CR0", "name": "SEC22B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269942", "map_id": "DDB_G0269942", "name": "SEC22B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GJ4", "map_id": "Q55GJ4", "name": "BNIP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267646", "map_id": "DDB_G0267646", "name": "BNIP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TZ2", "map_id": "Q54TZ2", "name": "STX18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281429", "map_id": "DDB_G0281429", "name": "STX18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LH0", "map_id": "Q54LH0", "name": "USE1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286811", "map_id": "DDB_G0286811", "name": "USE1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10617536", "map_id": "none", "name": "SEC22B:STX18:USE1:BNIP1L:3xSNAPs:NSF hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10617491", "map_id": "none", "name": "RAB:GTP recruits GBF1 to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10617199", "map_id": "none", "name": "RAB1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q552K3", "map_id": "Q552K3", "name": "rab1E", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275969", "map_id": "DDB_G0275969", "name": "rab1E", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NU2", "map_id": "Q54NU2", "name": "rab1D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284985", "map_id": "DDB_G0284985", "name": "rab1D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34139", "map_id": "P34139", "name": "rab1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283757", "map_id": "DDB_G0283757", "name": "rab1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KWT0", "map_id": "Q7KWT0", "name": "rabW", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276295", "map_id": "DDB_G0276295", "name": "rabW", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q558I0", "map_id": "Q558I0", "name": "rabF1-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272905", "map_id": "DDB_G0272905", "name": "rabF1-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34141", "map_id": "P34141", "name": "rabA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291233", "map_id": "DDB_G0291233", "name": "rabA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34140", "map_id": "P34140", "name": "rab1B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277867", "map_id": "DDB_G0277867", "name": "rab1B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54EW9", "map_id": "Q54EW9", "name": "rabU", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291293", "map_id": "DDB_G0291293", "name": "rabU", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34143", "map_id": "P34143", "name": "rabC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271736", "map_id": "DDB_G0271736", "name": "rabC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10616771", "map_id": "none", "name": "Homologues of GBF1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86KG9", "map_id": "Q86KG9", "name": "GBF1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290771", "map_id": "DDB_G0290771", "name": "GBF1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FL9", "map_id": "Q54FL9", "name": "GBF1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54X30", "map_id": "Q54X30", "name": "GBF1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10617489", "map_id": "none", "name": "RAB1:GTP:GBF1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10617507", "map_id": "none", "name": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10617503", "map_id": "none", "name": "Golgi-to-ER cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q86JE5", "map_id": "Q86JE5", "name": "kdelr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272124", "map_id": "DDB_G0272124", "name": "kdelr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q769F9", "map_id": "Q769F9", "name": "empA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288053", "map_id": "DDB_G0288053", "name": "empA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BN0", "map_id": "Q54BN0", "name": "empB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293540", "map_id": "DDB_G0293540", "name": "empB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q556J9", "map_id": "Q556J9", "name": "surf1-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272889", "map_id": "DDB_G0272889", "name": "surf1-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q769F6", "map_id": "Q769F6", "name": "empD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277923", "map_id": "DDB_G0277923", "name": "empD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q769F7", "map_id": "Q769F7", "name": "empC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278969", "map_id": "DDB_G0278969", "name": "empC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10616863", "map_id": "none", "name": "ARFGAP1,2,3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54DK9", "map_id": "Q54DK9", "name": "ARFGAP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292148", "map_id": "DDB_G0292148", "name": "ARFGAP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TP9", "map_id": "Q54TP9", "name": "ARFGAP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10617497", "map_id": "Q55CR0", "name": "SEC22B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10617495", "map_id": "none", "name": "RAB1:GTP:GBF1:ARF:GTP:coatomer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q55EZ6", "map_id": "Q55EZ6", "name": "copd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268702", "map_id": "DDB_G0268702", "name": "copd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23924", "map_id": "Q23924", "name": "copb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284735", "map_id": "DDB_G0284735", "name": "copb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HL0", "map_id": "Q54HL0", "name": "copG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289371", "map_id": "DDB_G0289371", "name": "copG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CA7", "map_id": "Q54CA7", "name": "copZb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293086", "map_id": "DDB_G0293086", "name": "copZb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HD4", "map_id": "Q54HD4", "name": "copZa", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289523", "map_id": "DDB_G0289523", "name": "copZa", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YD8", "map_id": "Q54YD8", "name": "copb2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278285", "map_id": "DDB_G0278285", "name": "copb2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FU2", "map_id": "Q55FU2", "name": "cope", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267950", "map_id": "DDB_G0267950", "name": "cope", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FR9", "map_id": "Q55FR9", "name": "copa", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267982", "map_id": "DDB_G0267982", "name": "copa", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10617233", "map_id": "none", "name": "p24 dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10617505", "map_id": "none", "name": "RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10617539", "map_id": "none", "name": "NSF ATPase activity dissociates cis-SNARE at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10617532", "map_id": "Q54LH0", "name": "USE1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10617527", "map_id": "Q54TZ2", "name": "STX18", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10587872", "map_id": "Q55CR0", "name": "SEC22B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10617522", "map_id": "Q55GJ4", "name": "BNIP1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10617652", "map_id": "none", "name": "COPI vesicle uncoating at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10617646", "map_id": "none", "name": "RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo:NBAS:RINT1:ZW10:STX18:USE1L:BNIP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q55CJ0", "map_id": "Q55CJ0", "name": "RINT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270040", "map_id": "DDB_G0270040", "name": "RINT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CA1", "map_id": "Q55CA1", "name": "ZW10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270150", "map_id": "DDB_G0270150", "name": "ZW10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YZ1", "map_id": "Q54YZ1", "name": "NBAS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277997", "map_id": "DDB_G0277997", "name": "NBAS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10617644", "map_id": "none", "name": "Golgi-to-ER cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10616843", "map_id": "none", "name": "coatomer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10617604", "map_id": "none", "name": "p24 dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10611571", "map_id": "none", "name": "RAB1:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10618658", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10618647", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2:RAB18:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54UJ4", "map_id": "Q54UJ4", "name": "RAB3GAP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281043", "map_id": "DDB_G0281043", "name": "RAB3GAP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DM6", "map_id": "Q54DM6", "name": "RAB3GAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292124", "map_id": "DDB_G0292124", "name": "RAB3GAP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GY8", "map_id": "Q54GY8", "name": "rab18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289827", "map_id": "DDB_G0289827", "name": "rab18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10618655", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2:RAB18:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10618649", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10618633", "map_id": "none", "name": "RAB18:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10618645", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10618509", "map_id": "none", "name": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_8848483", "map_id": "CHEBI:17504", "name": "2-lysophosphatidylcholine", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_429785", "map_id": "CHEBI:16110", "name": "PC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10618506", "map_id": "Q54IG1", "name": "AGPAT3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "DDB_G0288863", "map_id": "DDB_G0288863", "name": "AGPAT3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10589211", "map_id": "none", "name": "Arginine<=>Agmatine+CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_351164", "map_id": "CHEBI:17431", "name": "AGM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10589208", "map_id": "Q54UF3", "name": "odc", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0281109", "map_id": "DDB_G0281109", "name": "odc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10590640", "map_id": "none", "name": "Transport of L1 into endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17940", "compartment_display": "endosome" }, { "id": "species_10590638", "map_id": "none", "name": "L1:AP-2 Clathrin complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20592", "compartment_display": "clathrin-coated endocytic vesicle", "complex": "true" }, { "id": "Q54F41", "map_id": "Q54F41", "name": "SH3RF1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291131", "map_id": "DDB_G0291131", "name": "SH3RF1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DN5", "map_id": "Q54DN5", "name": "AF310889_1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291984", "map_id": "DDB_G0291984", "name": "AF310889_1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P25870", "map_id": "P25870", "name": "chcA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277221", "map_id": "DDB_G0277221", "name": "chcA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MN58", "map_id": "Q8MN58", "name": "clc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277403", "map_id": "DDB_G0277403", "name": "clc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54H39", "map_id": "Q54H39", "name": "ap2s1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289721", "map_id": "DDB_G0289721", "name": "ap2s1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54X82", "map_id": "Q54X82", "name": "ap1b1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279141", "map_id": "DDB_G0279141", "name": "ap1b1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86KI1", "map_id": "Q86KI1", "name": "ap2a1-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273439", "map_id": "DDB_G0273439", "name": "ap2a1-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54672", "map_id": "P54672", "name": "apm2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277139", "map_id": "DDB_G0277139", "name": "apm2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10594030", "map_id": "none", "name": "Formation of clathrin coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10585860", "map_id": "none", "name": "Homologues of SH3GL2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10594019", "map_id": "none", "name": "L1:clathrin-coated vesicle", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10594027", "map_id": "none", "name": "Dynamin-1/2/3", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10611540", "map_id": "none", "name": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10611519", "map_id": "none", "name": "GCSH:SAMDLL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54JV8", "map_id": "Q54JV8", "name": "gcvH1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287773", "map_id": "DDB_G0287773", "name": "gcvH1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:14949", "map_id": "CHEBI:14949", "name": "CHEBI:14949", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_200671", "map_id": "CHEBI:15635", "name": "THF", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10611532", "map_id": "none", "name": "GCSH:DHLL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:50746", "map_id": "CHEBI:50746", "name": "CHEBI:50746", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5693978", "map_id": "CHEBI:16134", "name": "NH3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5693984", "map_id": "CHEBI:12071", "name": "5,10-methylene-THF", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10611537", "map_id": "Q54DD3", "name": "gcvT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0292326", "map_id": "DDB_G0292326", "name": "gcvT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10611545", "map_id": "none", "name": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10611515", "map_id": "Q54JV8", "name": "gcvH1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10611542", "map_id": "none", "name": "DLD dimer:2xFAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54EW8", "map_id": "Q54EW8", "name": "lpd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291648", "map_id": "DDB_G0291648", "name": "lpd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10611530", "map_id": "none", "name": "PXLP-K754-GLDC dimer decarboxylates Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_159549", "map_id": "CHEBI:57305", "name": "Gly", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10611527", "map_id": "none", "name": "PXLP-K754-GLDC dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54KM7", "map_id": "Q54KM7", "name": "gcvP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287255", "map_id": "DDB_G0287255", "name": "gcvP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10590766", "map_id": "none", "name": "cGMP is degraded by PDEs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30991", "map_id": "CHEBI:16356", "name": "cGMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10590763", "map_id": "none", "name": "cGMP phosphodiesterases", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "B0G0Y8", "map_id": "B0G0Y8", "name": "pde3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268634", "map_id": "DDB_G0268634", "name": "pde3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10590749", "map_id": "none", "name": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10590744", "map_id": "Q55CT1", "name": "redB", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10618498", "map_id": "none", "name": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_30209", "map_id": "CHEBI:17336", "name": "atROL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2534407", "map_id": "CHEBI:17616", "name": "atR-PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10611937", "map_id": "Q54GC1", "name": "dgat2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0290279", "map_id": "DDB_G0290279", "name": "dgat2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10590501", "map_id": "none", "name": "FAR1 reduces PalmCoA to HXOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_8848577", "map_id": "CHEBI:16125", "name": "HXOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10590498", "map_id": "Q54I12", "name": "FAR1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "false" }, { "id": "DDB_G0289081", "map_id": "DDB_G0289081", "name": "FAR1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10590503", "map_id": "none", "name": "FAR2 reduces PalmCoA to HXOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "reaction_10618495", "map_id": "none", "name": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8848499", "map_id": "CHEBI:75584", "name": "PALM-PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10611935", "map_id": "none", "name": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_192172", "map_id": "CHEBI:17984", "name": "Acyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_5696426", "map_id": "CHEBI:75627", "name": "ARACOH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_5696412", "map_id": "CHEBI:10036", "name": "arachidyl ester", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10611932", "map_id": "Q54GC1", "name": "dgat2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10588683", "map_id": "none", "name": "Tryptophan is hydroxylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29500", "map_id": "CHEBI:57912", "name": "L-Trp", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_71112", "map_id": "CHEBI:15374", "name": "4aOH-BH4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_209911", "map_id": "CHEBI:17780", "name": "5HTP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10588680", "map_id": "none", "name": "TPH:Fe++", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54XS1", "map_id": "Q54XS1", "name": "pah", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278781", "map_id": "DDB_G0278781", "name": "pah", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10588667", "map_id": "none", "name": "Methylation of N-acetyl-5-HT to form melatonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_71284", "map_id": "CHEBI:15414", "name": "AdoMet", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_209793", "map_id": "CHEBI:17697", "name": "Ac5HT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_209934", "map_id": "CHEBI:16796", "name": "MLT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_71285", "map_id": "CHEBI:16680", "name": "AdoHcy", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10588664", "map_id": "none", "name": "Homologues of ASMT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86I40", "map_id": "Q86I40", "name": "omt4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275013", "map_id": "DDB_G0275013", "name": "omt4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54B59", "map_id": "Q54B59", "name": "omt12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293888", "map_id": "DDB_G0293888", "name": "omt12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GZ0", "map_id": "Q54GZ0", "name": "omt9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289823", "map_id": "DDB_G0289823", "name": "omt9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54S95", "map_id": "Q54S95", "name": "omt7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282591", "map_id": "DDB_G0282591", "name": "omt7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T638", "map_id": "Q8T638", "name": "dmtA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289329", "map_id": "DDB_G0289329", "name": "dmtA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54B60", "map_id": "Q54B60", "name": "omt11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293886", "map_id": "DDB_G0293886", "name": "omt11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FP4", "map_id": "Q54FP4", "name": "omt10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290719", "map_id": "DDB_G0290719", "name": "omt10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86HS9", "map_id": "Q86HS9", "name": "omt2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274941", "map_id": "DDB_G0274941", "name": "omt2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10606827", "map_id": "none", "name": "Active MTORC1 phosphorylates ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10606817", "map_id": "none", "name": "MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "Q54D08", "map_id": "Q54D08", "name": "lst8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292592", "map_id": "DDB_G0292592", "name": "lst8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86C65", "map_id": "Q86C65", "name": "tor", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281569", "map_id": "DDB_G0281569", "name": "tor", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BR7", "map_id": "Q55BR7", "name": "raptor", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270398", "map_id": "DDB_G0270398", "name": "raptor", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PK6", "map_id": "Q54PK6", "name": "RRAGD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284495", "map_id": "DDB_G0284495", "name": "RRAGD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IK1", "map_id": "Q54IK1", "name": "ragA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288701", "map_id": "DDB_G0288701", "name": "ragA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86J23", "map_id": "Q86J23", "name": "LAMTOR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274833", "map_id": "DDB_G0274833", "name": "LAMTOR3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DY3", "map_id": "Q54DY3", "name": "LAMTOR4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291948", "map_id": "DDB_G0291948", "name": "LAMTOR4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXA8", "map_id": "Q1ZXA8", "name": "LAMTOR1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292160", "map_id": "DDB_G0292160", "name": "LAMTOR1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54F59", "map_id": "Q54F59", "name": "mapbpip", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291091", "map_id": "DDB_G0291091", "name": "mapbpip", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QW5", "map_id": "Q54QW5", "name": "LAMTOR5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283567", "map_id": "DDB_G0283567", "name": "LAMTOR5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DD9", "map_id": "Q54DD9", "name": "rsmD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292318", "map_id": "DDB_G0292318", "name": "rsmD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54J54", "map_id": "Q54J54", "name": "ATG101", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288287", "map_id": "DDB_G0288287", "name": "ATG101", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BY0", "map_id": "Q55BY0", "name": "U81000", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269162", "map_id": "DDB_G0269162", "name": "U81000", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86CS2", "map_id": "Q86CS2", "name": "atg1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292390", "map_id": "DDB_G0292390", "name": "atg1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10606824", "map_id": "none", "name": "MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10607979", "map_id": "none", "name": "The phagophore extends from the PIP3-enriched structure", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10606839", "map_id": "none", "name": "ATG14:PIK3C3:PIK3R4:p-S15-BECN1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54JI9", "map_id": "Q54JI9", "name": "phospho-atg6B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288021", "map_id": "DDB_G0288021", "name": "phospho-atg6B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54676", "map_id": "P54676", "name": "pikE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289601", "map_id": "DDB_G0289601", "name": "pikE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54S77", "map_id": "Q54S77", "name": "vps15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282627", "map_id": "DDB_G0282627", "name": "vps15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10607970", "map_id": "none", "name": "ATG14:PIK3C3:PIK3R4:p-S15-BECN1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "true" }, { "id": "species_10607975", "map_id": "Q54NA3", "name": "atg9", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "false" }, { "id": "DDB_G0285323", "map_id": "DDB_G0285323", "name": "atg9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10626468", "map_id": "none", "name": "Parkin binds Ub:UBE2N:UBE2V1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10596322", "map_id": "none", "name": "Homologues of PARK2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8T2Q2", "map_id": "Q8T2Q2", "name": "ARIH2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IL3", "map_id": "Q54IL3", "name": "ARIH2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XG4", "map_id": "Q54XG4", "name": "ARIH2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10626464", "map_id": "none", "name": "Ub:UBE2N:UBE2V1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10626466", "map_id": "none", "name": "Ub:UBE2N:UBE2V1:PRKN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10626478", "map_id": "none", "name": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10626474", "map_id": "none", "name": "Homologues of Misfolded CETN1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54IY3", "map_id": "Q54IY3", "name": "cenA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288427", "map_id": "DDB_G0288427", "name": "cenA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54X77", "map_id": "Q54X77", "name": "cenB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279151", "map_id": "DDB_G0279151", "name": "cenB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10626476", "map_id": "none", "name": "Misfolded proteins:PRKN:UBE2N:UBE2V1:Ub", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10626510", "map_id": "none", "name": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10626506", "map_id": "none", "name": "Ub:Misfolded proteins:PRKN:UBE2N:UBE2V1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54U44", "map_id": "Q54U44", "name": "abcC12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280973", "map_id": "DDB_G0280973", "name": "abcC12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54P13", "map_id": "Q54P13", "name": "abcC8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284867", "map_id": "DDB_G0284867", "name": "abcC8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8ST87", "map_id": "Q8ST87", "name": "abcC10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280977", "map_id": "DDB_G0280977", "name": "abcC10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LE6", "map_id": "Q54LE6", "name": "abcC5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286559", "map_id": "DDB_G0286559", "name": "abcC5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JR2", "map_id": "Q54JR2", "name": "abcC3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287691", "map_id": "DDB_G0287691", "name": "abcC3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10626492", "map_id": "none", "name": "PolyUb:Misfolded proteins:PRKN:UBE2N:UBE2V1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10626494", "map_id": "none", "name": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10626490", "map_id": "none", "name": "PolyUb-Misfolded Proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10626480", "map_id": "none", "name": "UBE2N:UBE2V1:PRKN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10626559", "map_id": "none", "name": "Aggresome dissociates from dynein and microtubule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_18667", "compartment_display": "microtubule organizing center" }, { "id": "species_10626551", "map_id": "none", "name": "Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18667", "compartment_display": "microtubule organizing center", "complex": "true" }, { "id": "Q54X15", "map_id": "Q54X15", "name": "hdaD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279267", "map_id": "DDB_G0279267", "name": "hdaD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10626557", "map_id": "none", "name": "Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10589898", "map_id": "none", "name": "Microtubule", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10605681", "map_id": "none", "name": "Dynein complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10626508", "map_id": "none", "name": "Parkin transfers Ub to misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10626541", "map_id": "none", "name": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10626537", "map_id": "none", "name": "PolyUb-Misfolded Proteins:HDAC6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10626539", "map_id": "none", "name": "PolyUb-Misfolded Proteins:HDAC6:Dynein complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10623347", "map_id": "none", "name": "FUNDC1 is phosphorylated by CK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10623342", "map_id": "Q75K07", "name": "FUNDC1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "DDB_G0277699", "map_id": "DDB_G0277699", "name": "phospho-p-S17-FUNDC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10623345", "map_id": "Q75K07", "name": "phospho-p-S13-FUNDC1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10601344", "map_id": "none", "name": "Casein kinase II", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54PF1", "map_id": "Q54PF1", "name": "csnk2b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284601", "map_id": "DDB_G0284601", "name": "csnk2b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q02720", "map_id": "Q02720", "name": "casK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276885", "map_id": "DDB_G0276885", "name": "casK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LR6", "map_id": "Q54LR6", "name": "CSNK2A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286481", "map_id": "DDB_G0286481", "name": "CSNK2A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10623360", "map_id": "none", "name": "FUNDC1 is phosphorylated by ULK1 at Ser17", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10623357", "map_id": "Q75K07", "name": "phospho-p-S17-FUNDC1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10623349", "map_id": "Q86CS2", "name": "atg1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "reaction_10623351", "map_id": "none", "name": "ULK1 Translocates to the mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10606654", "map_id": "Q86CS2", "name": "atg1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10624119", "map_id": "none", "name": "LC3 binds the autophagosome membrane Atg5-Atg12 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_21994", "compartment_display": "phagocytic vesicle" }, { "id": "species_10604606", "map_id": "none", "name": "ATG5:ATG12", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222693", "compartment_display": "phagocytic vesicle membrane", "complex": "true" }, { "id": "Q86CR6", "map_id": "Q86CR6", "name": "atg12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282929", "map_id": "DDB_G0282929", "name": "atg12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GT9", "map_id": "Q54GT9", "name": "atg5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289881", "map_id": "DDB_G0289881", "name": "atg5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10624115", "map_id": "none", "name": "p-S17-FUNDC1:LC3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q86CR8", "map_id": "Q86CR8", "name": "atg8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286191", "map_id": "DDB_G0286191", "name": "atg8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54G11", "map_id": "Q54G11", "name": "MAP1LC3B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290491", "map_id": "DDB_G0290491", "name": "MAP1LC3B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q75K07", "map_id": "Q75K07", "name": "phospho-p-S17-FUNDC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10624117", "map_id": "none", "name": "p-S17-FUNDC1:LC3:ATG5:ATG12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10624121", "map_id": "none", "name": "Phosphorylated FUNDC1 links damaged mitochondria to LC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10624113", "map_id": "none", "name": "LC3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10627184", "map_id": "none", "name": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10627180", "map_id": "none", "name": "ATM dimer:Ub-p-PEX5:SQSTM1:NBR1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "Q54Q21", "map_id": "Q54Q21", "name": "Q54Q21", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284133", "map_id": "DDB_G0284133", "name": "Q54Q21", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MD1", "map_id": "Q54MD1", "name": "phospho-pex5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286033", "map_id": "DDB_G0286033", "name": "phospho-pex5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10607651", "map_id": "none", "name": "Homologues of MAP1LC3B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10627182", "map_id": "none", "name": "ATM dimer:Ub-p-PEX5:SQSTM1:NBR1:MAP1LC3B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10627166", "map_id": "none", "name": "NBR1 binds MAP1LC3B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10627162", "map_id": "Q54Q21", "name": "Q54Q21", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "false" }, { "id": "species_10627164", "map_id": "none", "name": "NBR1:MAP1LC3B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10606829", "map_id": "none", "name": "p-AMPK:AMP binds the ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10606668", "map_id": "none", "name": "ULK1:ATG13:RB1CC1:ATG101", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10589958", "map_id": "none", "name": "p-AMPK heterotrimer:AMP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54UG7", "map_id": "Q54UG7", "name": "PRKAB2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281089", "map_id": "DDB_G0281089", "name": "PRKAB2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T277", "map_id": "Q8T277", "name": "prkag", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272542", "map_id": "DDB_G0272542", "name": "prkag", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YF2", "map_id": "Q54YF2", "name": "phospho-snfA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277905", "map_id": "DDB_G0277905", "name": "phospho-snfA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MV2", "map_id": "Q54MV2", "name": "phospho-mrkB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285643", "map_id": "DDB_G0285643", "name": "phospho-mrkB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10606670", "map_id": "none", "name": "p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10607596", "map_id": "none", "name": "WIPIs bind PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5693050", "map_id": "CHEBI:17283", "name": "PI3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "false" }, { "id": "species_10607592", "map_id": "none", "name": "WIPI1,WIPI2,(WDR45,WDR45B)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54NA2", "map_id": "Q54NA2", "name": "atg18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285375", "map_id": "DDB_G0285375", "name": "atg18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10607594", "map_id": "none", "name": "WIPI1,WIPI2,(WDR45,WDR45B):PI3P", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "true" }, { "id": "species_1806200", "map_id": "CHEBI:17283", "name": "PI3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "reaction_10607732", "map_id": "none", "name": "ULK1 phosphorylates Beclin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10607717", "map_id": "none", "name": "Beclin-1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10607729", "map_id": "none", "name": "p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10608055", "map_id": "none", "name": "ATG7:ATG3:LC3 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10607764", "map_id": "none", "name": "LC3:CysO263-ATG3:ATG7 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86CR9", "map_id": "Q86CR9", "name": "atg7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271096", "map_id": "DDB_G0271096", "name": "atg7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q550A8", "map_id": "Q550A8", "name": "atg3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277319", "map_id": "DDB_G0277319", "name": "atg3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10607673", "map_id": "none", "name": "CysO263-ATG3:LC3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10607749", "map_id": "none", "name": "ATG7 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10607737", "map_id": "none", "name": "MTMR14, MTMR3 dephosphorylate PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5676030", "map_id": "CHEBI:26034", "name": "PI3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_426639", "map_id": "CHEBI:16749", "name": "PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10607734", "map_id": "none", "name": "MTMR3,MTMR14", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54H00", "map_id": "Q54H00", "name": "MTMR14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289807", "map_id": "DDB_G0289807", "name": "MTMR14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54C52", "map_id": "Q54C52", "name": "MTMR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293258", "map_id": "DDB_G0293258", "name": "MTMR3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55E04", "map_id": "Q55E04", "name": "MTMR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GQ1", "map_id": "Q54GQ1", "name": "MTMR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55E58", "map_id": "Q55E58", "name": "pats1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269250", "map_id": "DDB_G0269250", "name": "pats1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PL3", "map_id": "Q54PL3", "name": "MTMR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55EE1", "map_id": "Q55EE1", "name": "MTMR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PT8", "map_id": "Q54PT8", "name": "MTMR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TD5", "map_id": "Q54TD5", "name": "MTMR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YC2", "map_id": "Q54YC2", "name": "MTMR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AZ2", "map_id": "Q55AZ2", "name": "MTMR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXD2", "map_id": "Q1ZXD2", "name": "MTMR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BL7", "map_id": "Q55BL7", "name": "MTMR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10607739", "map_id": "none", "name": "ULK complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10607573", "map_id": "none", "name": "p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10606842", "map_id": "none", "name": "Beclin-1 complex phosphorylates PtdIns", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10607741", "map_id": "none", "name": "WIPI2 binds ATG12:ATG5:ATG16L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10607693", "map_id": "none", "name": "WIPI2:PI(3,5)P2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "true" }, { "id": "species_1806205", "map_id": "CHEBI:16851", "name": "PI(3,5)P2", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10607691", "map_id": "none", "name": "ATG16L1 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O15736", "map_id": "O15736", "name": "tipD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275323", "map_id": "DDB_G0275323", "name": "tipD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10607695", "map_id": "none", "name": "ATG16L1 complex:WIPI2:PI(3,5)P2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "true" }, { "id": "reaction_10606846", "map_id": "none", "name": "Rheb in the MTORC1 complex hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10584242", "map_id": "none", "name": "Active mTORC1 complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10589976", "map_id": "none", "name": "mTORC1:Ragulator:Rag:GNP:RHEB:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10607747", "map_id": "none", "name": "Beclin-1 complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10607745", "map_id": "none", "name": "BECN1 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10606850", "map_id": "none", "name": "Active MTORC1 binds the ULK1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10607753", "map_id": "none", "name": "ATG12 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10607684", "map_id": "Q86CR6", "name": "atg12", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10607751", "map_id": "none", "name": "ATG12:ATG7 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10607564", "map_id": "none", "name": "MTORC1 dissociates from ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10607256", "map_id": "none", "name": "MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10606822", "map_id": "none", "name": "p-S758-ULK1:ATG13:RB1CC1:ATG101", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10584309", "map_id": "none", "name": "mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10625487", "map_id": "none", "name": "ATG12 forms a thioester bond with ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10608021", "map_id": "none", "name": "ATG12:ATG7:CysO572-ATG7", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10608017", "map_id": "none", "name": "Autophagosome maturation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5683628", "compartment_display": "autophagosome membrane" }, { "id": "species_10607675", "map_id": "none", "name": "LC3:PE", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "true" }, { "id": "species_10608008", "map_id": "none", "name": "LC3:PE", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5683628", "compartment_display": "autophagosome membrane", "complex": "true" }, { "id": "species_10608015", "map_id": "none", "name": "UVRAG complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54JC5", "map_id": "Q54JC5", "name": "UVRAG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288175", "map_id": "DDB_G0288175", "name": "UVRAG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10594491", "map_id": "none", "name": "ESCRT-III", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54GK9", "map_id": "Q54GK9", "name": "chmp2a1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290087", "map_id": "DDB_G0290087", "name": "chmp2a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KZ4", "map_id": "Q54KZ4", "name": "chmp6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287021", "map_id": "DDB_G0287021", "name": "chmp6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54P63", "map_id": "Q54P63", "name": "chmp3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284769", "map_id": "DDB_G0284769", "name": "chmp3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JK4", "map_id": "Q54JK4", "name": "chmp5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287993", "map_id": "DDB_G0287993", "name": "chmp5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86H98", "map_id": "Q86H98", "name": "chmp4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275573", "map_id": "DDB_G0275573", "name": "chmp4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10607824", "map_id": "none", "name": "LC3 is cleaved by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10607793", "map_id": "none", "name": "LC3 family precursors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10607665", "map_id": "none", "name": "LC3 family", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10607821", "map_id": "none", "name": "ATG4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q557H7", "map_id": "Q557H7", "name": "atg4-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273443", "map_id": "DDB_G0273443", "name": "atg4-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10607826", "map_id": "none", "name": "LC3 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10607760", "map_id": "none", "name": "LC3:CysO572-ATG7:ATG7", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10607698", "map_id": "none", "name": "ATG16L1 complex transfers LC3 from ATG3 to PE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5681998", "map_id": "CHEBI:16038", "name": "PE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "false" }, { "id": "species_10607677", "map_id": "Q550A8", "name": "atg3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10608023", "map_id": "none", "name": "LC3:ATG7 dimer binds ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10607762", "map_id": "none", "name": "LC3:CysO572-ATG7:ATG7:ATG3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10607767", "map_id": "none", "name": "ATG3 transfers LC3 from ATG7 to ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10607576", "map_id": "none", "name": "ULK1 phosphorylates ATG13 and RB1CC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10606812", "map_id": "none", "name": "p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10607258", "map_id": "none", "name": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10608090", "map_id": "none", "name": "ULK1 is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10606684", "map_id": "none", "name": "AMPK (complex) phosphorylates ULK1 (complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10606681", "map_id": "none", "name": "p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10606815", "map_id": "none", "name": "Thr-180 of ULK1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10607966", "map_id": "none", "name": "LC3 de-lipidation by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10611248", "map_id": "none", "name": "APEH hydrolyses NAc-Ser-protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5691496", "map_id": "none", "name": "NAc-Ser:protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_5691517", "map_id": "CHEBI:83690", "name": "NAc-Ser residue", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6785226", "map_id": "CHEBI:36080", "name": "protein", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10611245", "map_id": "Q55GA9", "name": "APEH", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0267742", "map_id": "DDB_G0267742", "name": "APEH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10616060", "map_id": "none", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10616038", "map_id": "none", "name": "ETF1 dimer:eRF3:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7YZN9", "map_id": "Q7YZN9", "name": "erf3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277919", "map_id": "DDB_G0277919", "name": "erf3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BMX0", "map_id": "Q9BMX0", "name": "erf1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288613", "map_id": "DDB_G0288613", "name": "erf1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10616045", "map_id": "none", "name": "Me-Q185-ETF1 dimer:eRF3:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10616057", "map_id": "none", "name": "N6AMT1:TRMT112", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54DT3", "map_id": "Q54DT3", "name": "N6AMT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292048", "map_id": "DDB_G0292048", "name": "N6AMT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54N57", "map_id": "Q54N57", "name": "TRMT112", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285489", "map_id": "DDB_G0285489", "name": "TRMT112", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10601939", "map_id": "none", "name": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10601743", "map_id": "none", "name": "SUMO1:C93-UBE2I", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54KR7", "map_id": "Q54KR7", "name": "UBE2I", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287153", "map_id": "DDB_G0287153", "name": "UBE2I", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NGP4", "map_id": "Q9NGP4", "name": "ubc9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287693", "map_id": "DDB_G0287693", "name": "ubc9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10601921", "map_id": "none", "name": "RANGAP1 homodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "Q54N16", "map_id": "Q54N16", "name": "SUMO1-K524-RANGAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285563", "map_id": "DDB_G0285563", "name": "SUMO1-K524-RANGAP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10601725", "map_id": "none", "name": "Homologues of UBE2I", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10601936", "map_id": "none", "name": "SUMO1:RANGAP1 homodimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "reaction_10626247", "map_id": "none", "name": "RCC1 stimulates GDP to GTP exchange on RAN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1598585", "compartment_display": "chromosome" }, { "id": "species_10587842", "map_id": "none", "name": "RAN:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P33519", "map_id": "P33519", "name": "ranA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291235", "map_id": "DDB_G0291235", "name": "ranA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10626239", "map_id": "none", "name": "RAN:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10626244", "map_id": "Q55C31", "name": "RCC1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_1598585", "compartment_display": "chromosome", "complex": "false" }, { "id": "DDB_G0270246", "map_id": "DDB_G0270246", "name": "RCC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10626251", "map_id": "none", "name": "RAN:GTP recruits nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9624879", "map_id": "none", "name": "Nuclear envelope vesicle", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_10626249", "map_id": "none", "name": "RAN:GTP:Nuclear envelope vesicles", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "reaction_10626254", "map_id": "none", "name": "RAN stimulates fusion of nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9624890", "map_id": "none", "name": "Fused nuclear envelope vesicles", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "reaction_10627210", "map_id": "none", "name": "CHMP7 binds CC2D1B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10627194", "map_id": "Q54QK5", "name": "CC2D1B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "DDB_G0283793", "map_id": "DDB_G0283793", "name": "CC2D1B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10627200", "map_id": "none", "name": "LEMD2:ESCRT-III:IST1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "Q54I39", "map_id": "Q54I39", "name": "IST1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289029", "map_id": "DDB_G0289029", "name": "IST1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10627202", "map_id": "none", "name": "LEM2D:ESCRT-III:IST1:CC2D1B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "Q54QK5", "map_id": "Q54QK5", "name": "CC2D1B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10627208", "map_id": "none", "name": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10594774", "map_id": "Q54PT2", "name": "vps4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0284347", "map_id": "DDB_G0284347", "name": "vps4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10627204", "map_id": "none", "name": "LEM2D:ESCRT-III:IST1:CC2D1B:SPAST", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "Q54KQ7", "map_id": "Q54KQ7", "name": "SPAST", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287165", "map_id": "DDB_G0287165", "name": "SPAST", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10627206", "map_id": "none", "name": "LEM2D:ESCRT-III:IST1:CC2D1B:SPAST:VPS4A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "Q54PT2", "map_id": "Q54PT2", "name": "vps4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10627215", "map_id": "none", "name": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10589894", "map_id": "none", "name": "alpha-beta tubulin dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10627212", "map_id": "none", "name": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10627189", "map_id": "Q54KQ7", "name": "SPAST", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10606306", "map_id": "none", "name": "AKR1B1 reduces Glc to D-sorbitol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_70113", "map_id": "CHEBI:17925", "name": "Glc", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_5652213", "map_id": "CHEBI:17924", "name": "D-sorbitol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10586772", "map_id": "none", "name": "Homologues of AKR1B1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55FL3", "map_id": "Q55FL3", "name": "alrC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268058", "map_id": "DDB_G0268058", "name": "alrC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6IMN8", "map_id": "Q6IMN8", "name": "alrA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293850", "map_id": "DDB_G0293850", "name": "alrA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NZ7", "map_id": "Q54NZ7", "name": "alrB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285053", "map_id": "DDB_G0285053", "name": "alrB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FL2", "map_id": "Q55FL2", "name": "AKR1C4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268562", "map_id": "DDB_G0268562", "name": "AKR1C4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10577683", "map_id": "none", "name": "KHK dimer phosphorylates Fru to Fru 1-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29532", "map_id": "CHEBI:15824", "name": "Fru", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_31221", "map_id": "CHEBI:18105", "name": "Fru 1-P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10577680", "map_id": "none", "name": "KHK dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54D80", "map_id": "Q54D80", "name": "KHK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292440", "map_id": "DDB_G0292440", "name": "KHK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10577703", "map_id": "none", "name": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30393", "map_id": "CHEBI:17378", "name": "GA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10577700", "map_id": "none", "name": "TKFC:2Mg2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55EE0", "map_id": "Q55EE0", "name": "dhak", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269274", "map_id": "DDB_G0269274", "name": "dhak", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10577693", "map_id": "none", "name": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10617821", "map_id": "none", "name": "ALDH1A1 oxidises GA to DGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6799497", "map_id": "CHEBI:32398", "name": "DGA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10578688", "map_id": "none", "name": "ALDH1A1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54IU0", "map_id": "Q54IU0", "name": "ALDH1A3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288521", "map_id": "DDB_G0288521", "name": "ALDH1A3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10605267", "map_id": "none", "name": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10605263", "map_id": "none", "name": "MSH2:MSH6:ATP:DNA containing 1-2 base mismatch", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q553L4", "map_id": "Q553L4", "name": "msh2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275809", "map_id": "DDB_G0275809", "name": "msh2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GU9", "map_id": "Q55GU9", "name": "msh6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268614", "map_id": "DDB_G0268614", "name": "msh6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10577431", "map_id": "none", "name": "PCNA homotrimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54K47", "map_id": "Q54K47", "name": "pcna", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287607", "map_id": "DDB_G0287607", "name": "pcna", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10605249", "map_id": "none", "name": "MLH1:PMS2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54KD8", "map_id": "Q54KD8", "name": "mlh1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287393", "map_id": "DDB_G0287393", "name": "mlh1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QA0", "map_id": "Q54QA0", "name": "pms1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283981", "map_id": "DDB_G0283981", "name": "pms1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10605265", "map_id": "none", "name": "MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10605283", "map_id": "none", "name": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10605280", "map_id": "none", "name": "MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10605300", "map_id": "none", "name": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10605296", "map_id": "Q54ED2", "name": "exo1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10605298", "map_id": "none", "name": "EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10605302", "map_id": "none", "name": "MSH2:MSH6 exchanges ADP for ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10605287", "map_id": "none", "name": "MSH2:MSH6:ADP:DNA containing 1-2 base mismatch", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10605289", "map_id": "none", "name": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10605285", "map_id": "none", "name": "MSH2:MSH6:ADP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_5358514", "map_id": "none", "name": "DNA containing mismatch or 1-2 base IDL", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10605291", "map_id": "none", "name": "DNA ligase I ligates single stranded nick in double stranded DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_5358610", "map_id": "none", "name": "DNA containing single strand nick (5' phosphate, 3' hydroxyl)", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_109966", "map_id": "none", "name": "Repaired double-stranded DNA", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_164121", "map_id": "CHEBI:16027", "name": "AMP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10577488", "map_id": "Q869E1", "name": "lig1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0274493", "map_id": "DDB_G0274493", "name": "lig1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10605389", "map_id": "none", "name": "Formation of MSH2:MSH6 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10605259", "map_id": "Q55GU9", "name": "msh6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10605254", "map_id": "Q553L4", "name": "msh2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10605391", "map_id": "none", "name": "Formation of MSH1:PMS2 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10605247", "map_id": "Q54QA0", "name": "pms1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10605242", "map_id": "Q54KD8", "name": "mlh1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10605387", "map_id": "none", "name": "Formation of MSH2:MSH3 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10605272", "map_id": "Q1ZXH0", "name": "msh3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0281683", "map_id": "DDB_G0281683", "name": "msh3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10605274", "map_id": "none", "name": "MSH2:MSH3:ADP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q1ZXH0", "map_id": "Q1ZXH0", "name": "msh3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10605278", "map_id": "none", "name": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_5358527", "map_id": "none", "name": "DNA containing IDL of 2 or more bases", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10605276", "map_id": "none", "name": "MSH2:MSH3:ADP:DNA containing IDL of 2 bases or more", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10582371", "map_id": "none", "name": "Phosphorylation (Ser5) of RNA pol II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10582368", "map_id": "none", "name": "Pol II transcription complex containing extruded transcript to +30", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54P04", "map_id": "Q54P04", "name": "polr2g", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284891", "map_id": "DDB_G0284891", "name": "polr2g", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54R66", "map_id": "Q54R66", "name": "polr2k", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283365", "map_id": "DDB_G0283365", "name": "polr2k", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GG8", "map_id": "Q55GG8", "name": "rpb9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268306", "map_id": "DDB_G0268306", "name": "rpb9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P35084", "map_id": "P35084", "name": "phospho-polr2a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279193", "map_id": "DDB_G0279193", "name": "phospho-polr2a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54EH2", "map_id": "Q54EH2", "name": "polr2e", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291636", "map_id": "DDB_G0291636", "name": "polr2e", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54J75", "map_id": "Q54J75", "name": "polr2b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288257", "map_id": "DDB_G0288257", "name": "polr2b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DH7", "map_id": "Q54DH7", "name": "polr2c", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292244", "map_id": "DDB_G0292244", "name": "polr2c", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YW8", "map_id": "Q54YW8", "name": "polr2h", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278039", "map_id": "DDB_G0278039", "name": "polr2h", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FA8", "map_id": "Q54FA8", "name": "polr2f", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291037", "map_id": "DDB_G0291037", "name": "polr2f", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86JJ5", "map_id": "Q86JJ5", "name": "polr2j", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277677", "map_id": "DDB_G0277677", "name": "polr2j", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54S04", "map_id": "Q54S04", "name": "polr2d", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282739", "map_id": "DDB_G0282739", "name": "polr2d", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AB6", "map_id": "Q55AB6", "name": "polr2l", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272036", "map_id": "DDB_G0272036", "name": "polr2l", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WV4", "map_id": "Q54WV4", "name": "gtf2f1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279377", "map_id": "DDB_G0279377", "name": "gtf2f1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KT7", "map_id": "Q54KT7", "name": "gtf2f2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287131", "map_id": "DDB_G0287131", "name": "gtf2f2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54C29", "map_id": "Q54C29", "name": "gtf2h4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293228", "map_id": "DDB_G0293228", "name": "gtf2h4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86KZ2", "map_id": "Q86KZ2", "name": "gtf2h2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272362", "map_id": "DDB_G0272362", "name": "gtf2h2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55G81", "map_id": "Q55G81", "name": "repD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267414", "map_id": "DDB_G0267414", "name": "repD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CT8", "map_id": "Q55CT8", "name": "gtf2h5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269906", "map_id": "DDB_G0269906", "name": "gtf2h5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54I13", "map_id": "Q54I13", "name": "mnat1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289079", "map_id": "DDB_G0289079", "name": "mnat1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54685", "map_id": "P54685", "name": "cdk7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285417", "map_id": "DDB_G0285417", "name": "cdk7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55F19", "map_id": "Q55F19", "name": "cycH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268668", "map_id": "DDB_G0268668", "name": "cycH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FP1", "map_id": "Q55FP1", "name": "gtf2h1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268014", "map_id": "DDB_G0268014", "name": "gtf2h1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86IB5", "map_id": "Q86IB5", "name": "gtf2h3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275517", "map_id": "DDB_G0275517", "name": "gtf2h3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O00835", "map_id": "O00835", "name": "repB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278729", "map_id": "DDB_G0278729", "name": "repB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10582364", "map_id": "none", "name": "Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10582386", "map_id": "none", "name": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10582382", "map_id": "Q54K42", "name": "phospho-p-SUPT5H", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0287661", "map_id": "DDB_G0287661", "name": "phospho-p-SUPT5H", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10582376", "map_id": "Q54Y13", "name": "RNMT", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0278479", "map_id": "DDB_G0278479", "name": "RNMT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10582360", "map_id": "none", "name": "RNA Pol II with phosphorylated CTD: CE complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54HV6", "map_id": "Q54HV6", "name": "RNGTT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289199", "map_id": "DDB_G0289199", "name": "RNGTT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10582384", "map_id": "none", "name": "CE:Pol II CTD:Spt5 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54Y13", "map_id": "Q54Y13", "name": "RNMT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54K42", "map_id": "Q54K42", "name": "phospho-p-SUPT5H", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10582362", "map_id": "none", "name": "Activation of GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10583326", "map_id": "none", "name": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10582366", "map_id": "none", "name": "RNA Polymerase II CTD (phosphorylated) binds to CE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10582358", "map_id": "Q54HV6", "name": "RNGTT", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10577491", "map_id": "none", "name": "Joining of adjacent Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_68452", "map_id": "none", "name": "Okazaki fragment", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_69172", "map_id": "none", "name": "ligated okazaki fragment", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10577467", "map_id": "none", "name": "Formation of Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10577460", "map_id": "none", "name": "Processive complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54N97", "map_id": "Q54N97", "name": "pold1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285381", "map_id": "DDB_G0285381", "name": "pold1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TN8", "map_id": "Q54TN8", "name": "POLD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281641", "map_id": "DDB_G0281641", "name": "POLD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B0G131", "map_id": "B0G131", "name": "POLD3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0294609", "map_id": "DDB_G0294609", "name": "POLD3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SV8", "map_id": "Q54SV8", "name": "pola1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282191", "map_id": "DDB_G0282191", "name": "pola1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MM7", "map_id": "Q54MM7", "name": "PRIM1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285853", "map_id": "DDB_G0285853", "name": "PRIM1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BM5", "map_id": "Q55BM5", "name": "prim2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270442", "map_id": "DDB_G0270442", "name": "prim2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54S08", "map_id": "Q54S08", "name": "polA2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282731", "map_id": "DDB_G0282731", "name": "polA2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10577464", "map_id": "none", "name": "Processive complex:Okazaki fragment complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10577458", "map_id": "none", "name": "DNA Polymerase delta tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10577483", "map_id": "none", "name": "Removal of remaining Flap", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10577473", "map_id": "none", "name": "Processive complex:Okazaki fragments:Remaining Flap", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10577475", "map_id": "none", "name": "Processive complex:nicked DNA from adjacent Okazaki fragments", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10577471", "map_id": "none", "name": "Formation of the Flap Intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10577469", "map_id": "none", "name": "Processive complex:Okazaki fragment:Flap", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10595408", "map_id": "none", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_964831", "map_id": "none", "name": "(GlcNAc)2 (Man)8 glycans", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "CHEBI:60629", "map_id": "CHEBI:60629", "name": "CHEBI:60629", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:60628", "map_id": "CHEBI:60628", "name": "CHEBI:60628", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:60627", "map_id": "CHEBI:60627", "name": "CHEBI:60627", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_964752", "map_id": "CHEBI:4208", "name": "Man", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_964740", "map_id": "CHEBI:59087", "name": "(GlcNAc)2 (Man)5 (Asn)1", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10595395", "map_id": "none", "name": "MAN1A1/A2/C1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q54CH4", "map_id": "Q54CH4", "name": "MAN1C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292918", "map_id": "DDB_G0292918", "name": "MAN1C1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PP9", "map_id": "Q54PP9", "name": "MAN1C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PQ0", "map_id": "Q54PQ0", "name": "MAN1C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PQ1", "map_id": "Q54PQ1", "name": "MAN1C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55EU0", "map_id": "Q55EU0", "name": "MAN1C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10595410", "map_id": "none", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_964828", "map_id": "CHEBI:60637", "name": "(GlcNAc)2 (Man)7bc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10595398", "map_id": "none", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_915149", "map_id": "CHEBI:59092", "name": "(GlcNAc)2 (Man)9", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10595406", "map_id": "none", "name": "Addition of GlcNAc to the glycan on the A arm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_914003", "map_id": "CHEBI:16264", "name": "UDP-GlcNAc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_964837", "map_id": "CHEBI:60625", "name": "(GlcNAc)3 (Man)5 (Asn)1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10595403", "map_id": "Q54IX1", "name": "gnt3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "false" }, { "id": "DDB_G0288463", "map_id": "DDB_G0288463", "name": "gnt3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10593280", "map_id": "none", "name": "AUF1:mRNA complex is destroyed", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10593278", "map_id": "none", "name": "Ubiquitinated AUF1 Tetramer: Destabilized mRNA Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86I71", "map_id": "Q86I71", "name": "Ub-HNRNPD-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279695", "map_id": "DDB_G0279695", "name": "Ub-HNRNPD-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WE9", "map_id": "Q54WE9", "name": "Ub-HNRNPD-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10577240", "map_id": "none", "name": "26S proteasome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55GJ6", "map_id": "Q55GJ6", "name": "psmB6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267390", "map_id": "DDB_G0267390", "name": "psmB6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXD3", "map_id": "Q1ZXD3", "name": "psmD3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288621", "map_id": "DDB_G0288621", "name": "psmD3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BC8", "map_id": "Q54BC8", "name": "psmB5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293784", "map_id": "DDB_G0293784", "name": "psmB5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DM7", "map_id": "Q54DM7", "name": "psmA2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292122", "map_id": "DDB_G0292122", "name": "psmA2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BC6", "map_id": "Q54BC6", "name": "psmD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293752", "map_id": "DDB_G0293752", "name": "psmD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QR2", "map_id": "Q54QR2", "name": "psmB7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283679", "map_id": "DDB_G0283679", "name": "psmB7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27562", "map_id": "Q27562", "name": "psmA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282363", "map_id": "DDB_G0282363", "name": "psmA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NQ0", "map_id": "Q54NQ0", "name": "psmD13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285105", "map_id": "DDB_G0285105", "name": "psmD13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34120", "map_id": "P34120", "name": "psmA7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272831", "map_id": "DDB_G0272831", "name": "psmA7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86IJ1", "map_id": "Q86IJ1", "name": "psmD14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272566", "map_id": "DDB_G0272566", "name": "psmD14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DB2", "map_id": "Q54DB2", "name": "PSME4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292398", "map_id": "DDB_G0292398", "name": "PSME4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54UJ0", "map_id": "Q54UJ0", "name": "psmD12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281051", "map_id": "DDB_G0281051", "name": "psmD12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q556Q0", "map_id": "Q556Q0", "name": "psmB4-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273163", "map_id": "DDB_G0273163", "name": "psmB4-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54S82", "map_id": "Q54S82", "name": "PSMF1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282617", "map_id": "DDB_G0282617", "name": "PSMF1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54UB5", "map_id": "Q54UB5", "name": "psmD11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281315", "map_id": "DDB_G0281315", "name": "psmD11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55D66", "map_id": "Q55D66", "name": "psmB3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269772", "map_id": "DDB_G0269772", "name": "psmB3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q967U1", "map_id": "Q967U1", "name": "psmE3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285099", "map_id": "DDB_G0285099", "name": "psmE3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HW1", "map_id": "Q54HW1", "name": "psmD10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289189", "map_id": "DDB_G0289189", "name": "psmD10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DY7", "map_id": "Q55DY7", "name": "psmB2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269472", "map_id": "DDB_G0269472", "name": "psmB2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JM5", "map_id": "Q54JM5", "name": "psmD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287953", "map_id": "DDB_G0287953", "name": "psmD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PJ1", "map_id": "Q54PJ1", "name": "psmC6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284517", "map_id": "DDB_G0284517", "name": "psmC6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q552Y8", "map_id": "Q552Y8", "name": "psmD9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275753", "map_id": "DDB_G0275753", "name": "psmD9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86A21", "map_id": "Q86A21", "name": "psmB1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272969", "map_id": "DDB_G0272969", "name": "psmB1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P02889", "map_id": "P02889", "name": "psmD8-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272564", "map_id": "DDB_G0272564", "name": "psmD8-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34124", "map_id": "P34124", "name": "psmC5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292382", "map_id": "DDB_G0292382", "name": "psmC5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34123", "map_id": "P34123", "name": "psmC4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289003", "map_id": "DDB_G0289003", "name": "psmC4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WI8", "map_id": "Q54WI8", "name": "psmD7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279633", "map_id": "DDB_G0279633", "name": "psmD7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XM7", "map_id": "Q54XM7", "name": "psmA6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278847", "map_id": "DDB_G0278847", "name": "psmA6", "type": 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}, { "id": "DDB_G0270784", "map_id": "DDB_G0270784", "name": "psmC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27563", "map_id": "Q27563", "name": "psmA3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267408", "map_id": "DDB_G0267408", "name": "psmA3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10593258", "map_id": "none", "name": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10593573", "map_id": "none", "name": "Homologues of RAB27B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114584", "compartment_display": "platelet dense granule membrane", "complex": "true" }, { "id": "Q54P07", "map_id": "Q54P07", "name": "rab32D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285051", "map_id": "DDB_G0285051", "name": "rab32D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T193", "map_id": "Q8T193", "name": "GGC-RAB30", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0294577", "map_id": "DDB_G0294577", "name": "GGC-RAB30", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54S62", "map_id": "Q54S62", "name": "GGC-RAB30", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXG2", "map_id": "Q1ZXG2", "name": "GGC-RAB30", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54S63", "map_id": "Q54S63", "name": "rsmN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282651", "map_id": "DDB_G0282651", "name": "rsmN", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXN9", "map_id": "Q1ZXN9", "name": "GGC-RAB30", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55EF0", "map_id": "Q55EF0", "name": "rabT2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269262", "map_id": "DDB_G0269262", "name": "rabT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54E92", "map_id": "Q54E92", "name": "rabG1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291738", "map_id": "DDB_G0291738", "name": "rabG1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55EG6", "map_id": "Q55EG6", "name": "rabT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268910", "map_id": "DDB_G0268910", "name": "rabT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FL2", "map_id": "Q54FL2", "name": "rabG2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290783", "map_id": "DDB_G0290783", "name": "rabG2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86JC8", "map_id": "Q86JC8", "name": "rabH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275955", "map_id": "DDB_G0275955", "name": "rabH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54G48", "map_id": "Q54G48", "name": "rabO", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290407", "map_id": "DDB_G0290407", "name": "rabO", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86JP5", "map_id": "Q86JP5", "name": "rabR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271980", "map_id": "DDB_G0271980", "name": "rabR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10593601", "map_id": "none", "name": "Homologues of RAB27B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10593475", "map_id": "none", "name": "Exocytosis of platelet alpha granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10593433", "map_id": "none", "name": "Platelet alpha granule contents", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114506", "compartment_display": "platelet alpha granule lumen", "complex": "true" }, { "id": "Q55ET7", "map_id": "Q55ET7", "name": "OLA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268758", "map_id": "DDB_G0268758", "name": "OLA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DM8", "map_id": "Q55DM8", "name": "SRGN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269600", "map_id": "DDB_G0269600", "name": "SRGN", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FE2", "map_id": "Q55FE2", "name": "TOR1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268156", "map_id": "DDB_G0268156", "name": "TOR1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q553C3", "map_id": "Q553C3", "name": "VTI1B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275765", "map_id": "DDB_G0275765", "name": "VTI1B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KR6", "map_id": "Q54KR6", "name": "PCYOX1L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287201", "map_id": "DDB_G0287201", "name": "PCYOX1L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T2H0", "map_id": "Q8T2H0", "name": "cyri", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272190", "map_id": "DDB_G0272190", "name": "cyri", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P05095", "map_id": "P05095", "name": "abpA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268632", "map_id": "DDB_G0268632", "name": "abpA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54V78", "map_id": "Q54V78", "name": "ACTN1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280565", "map_id": "DDB_G0280565", "name": "ACTN1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PA3", "map_id": "Q54PA3", "name": "MAGED2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284679", "map_id": "DDB_G0284679", "name": "MAGED2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54D77", "map_id": "Q54D77", "name": "GTPBP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292538", "map_id": "DDB_G0292538", "name": "GTPBP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10593473", "map_id": "none", "name": "Platelet alpha granule contents", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10593506", "map_id": "none", "name": "Exocytosis of platelet dense granule content", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10593494", "map_id": "none", "name": "Platelet dense granule content", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114524", "compartment_display": "platelet dense granule lumen", "complex": "true" }, { "id": "Q54F16", "map_id": "Q54F16", "name": "CTSW", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291191", "map_id": "DDB_G0291191", "name": "CTSW", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P04988", "map_id": "P04988", "name": "cprA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290957", "map_id": "DDB_G0290957", "name": "cprA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10593504", "map_id": "none", "name": "Platelet dense granule content", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10593830", "map_id": "none", "name": "Release of platelet cytosolic components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10593734", "map_id": "none", "name": "Platelet releasate cytosolic proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54TA6", "map_id": "Q54TA6", "name": "TUBA1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281889", "map_id": "DDB_G0281889", "name": "TUBA1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P32255", "map_id": "P32255", "name": "tubA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287689", "map_id": "DDB_G0287689", "name": "tubA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GQ5", "map_id": "Q55GQ5", "name": "sodA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267420", "map_id": "DDB_G0267420", "name": "sodA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RN1", "map_id": "Q54RN1", "name": "sodB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283021", "map_id": "DDB_G0283021", "name": "sodB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RQ1", "map_id": "Q54RQ1", "name": "sodC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282993", "map_id": "DDB_G0282993", "name": "sodC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RX2", "map_id": "Q54RX2", "name": "TAGLN2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282859", "map_id": "DDB_G0282859", "name": "TAGLN2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54W22", "map_id": "Q54W22", "name": "PLEK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282287", "map_id": "DDB_G0282287", "name": "PLEK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q551W8", "map_id": "Q551W8", "name": "PLEK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ST8", "map_id": "Q54ST8", "name": "PLEK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q556T3", "map_id": "Q556T3", "name": "fip-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273107", "map_id": "DDB_G0273107", "name": "fip-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PQ2", "map_id": "Q54PQ2", "name": "ACTB(1-375)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287981", "map_id": "DDB_G0287981", "name": "ACTB(1-375)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q553U6", "map_id": "Q553U6", "name": "act22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275023", "map_id": "DDB_G0275023", "name": "act22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q554S6", "map_id": "Q554S6", "name": "act17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274131", "map_id": "DDB_G0274131", "name": "act17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CU2", "map_id": "Q55CU2", "name": "act26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269902", "map_id": "DDB_G0269902", "name": "act26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DS6", "map_id": "Q55DS6", "name": "ACTB(1-375)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P07828", "map_id": "P07828", "name": "act18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289489", "map_id": "DDB_G0289489", "name": "act18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DY5", "map_id": "Q55DY5", "name": "ACTB(1-375)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P07829", "map_id": "P07829", "name": "act3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289487", "map_id": "DDB_G0289487", "name": "act3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55EU6", "map_id": "Q55EU6", "name": "act23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268744", "map_id": "DDB_G0268744", "name": "act23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P07830", "map_id": "P07830", "name": "act9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269234", "map_id": "DDB_G0269234", "name": "act9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GX7", "map_id": "Q54GX7", "name": "act10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289811", "map_id": "DDB_G0289811", "name": "act10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HE7", "map_id": "Q54HE7", "name": "act28", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289511", "map_id": "DDB_G0289511", "name": "act28", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HE9", "map_id": "Q54HE9", "name": "act27", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289533", "map_id": "DDB_G0289533", "name": "act27", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HF0", "map_id": "Q54HF0", "name": "act25", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289507", "map_id": "DDB_G0289507", "name": "act25", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HF1", "map_id": "Q54HF1", "name": "act24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289505", "map_id": "DDB_G0289505", "name": "act24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JL1", "map_id": "Q54JL1", "name": "ACTB(1-375)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JV5", "map_id": "Q54JV5", "name": "arpG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287779", "map_id": "DDB_G0287779", "name": "arpG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54L54", "map_id": "Q54L54", "name": "act29", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286893", "map_id": "DDB_G0286893", "name": "act29", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JD4", "map_id": "Q54JD4", "name": "HABP4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288133", "map_id": "DDB_G0288133", "name": "HABP4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54686", "map_id": "P54686", "name": "aip1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278733", "map_id": "DDB_G0278733", "name": "aip1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54K81", "map_id": "Q54K81", "name": "talB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287505", "map_id": "DDB_G0287505", "name": "talB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P24639", "map_id": "P24639", "name": "nxnA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269160", "map_id": "DDB_G0269160", "name": "nxnA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PW0", "map_id": "Q54PW0", "name": "ANXA5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284261", "map_id": "DDB_G0284261", "name": "ANXA5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10593828", "map_id": "none", "name": "Platelet releasate cytosolic proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10593644", "map_id": "none", "name": "Surface deployment of platelet alpha granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10593628", "map_id": "none", "name": "Platelet alpha granule membrane components that are released on degranulation", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114510", "compartment_display": "platelet alpha granule membrane", "complex": "true" }, { "id": "Q55CV7", "map_id": "Q55CV7", "name": "tspC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270986", "map_id": "DDB_G0270986", "name": "tspC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CW7", "map_id": "Q55CW7", "name": "tspB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269872", "map_id": "DDB_G0269872", "name": "tspB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CV4", "map_id": "Q55CV4", "name": "tspD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270682", "map_id": "DDB_G0270682", "name": "tspD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CV5", "map_id": "Q55CV5", "name": "tspA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269110", "map_id": "DDB_G0269110", "name": "tspA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FQ9", "map_id": "Q55FQ9", "name": "lmpC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267440", "map_id": "DDB_G0267440", "name": "lmpC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BKJ9", "map_id": "Q9BKJ9", "name": "lmpB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287035", "map_id": "DDB_G0287035", "name": "lmpB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XYS8", "map_id": "Q9XYS8", "name": "lmpA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267406", "map_id": "DDB_G0267406", "name": "lmpA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RR0", "map_id": "Q54RR0", "name": "JFC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282977", "map_id": "DDB_G0282977", "name": "JFC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10593642", "map_id": "none", "name": "Platelet alpha granule membrane components that are released on degranulation", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10622966", "map_id": "none", "name": "AHR:2xHSP90:AIP:PTGES3 binds TCDD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10622994", "map_id": "none", "name": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10623002", "map_id": "none", "name": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10623000", "map_id": "none", "name": "2xHSP90AB1:AIP:PTGES3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10622998", "map_id": "none", "name": "AHR:TCDD", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10616539", "map_id": "none", "name": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_179838", "map_id": "CHEBI:16618", "name": "PI(3,4,5)P3", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10582573", "map_id": "none", "name": "AKT2:THEM4,TRIB3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q556W3", "map_id": "Q556W3", "name": "THEM4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273293", "map_id": "DDB_G0273293", "name": "THEM4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10582559", "map_id": "Q556W3", "name": "THEM4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10582575", "map_id": "none", "name": "AKT2:PIP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10582601", "map_id": "none", "name": "PDPK1 phosphorylates AKT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10582598", "map_id": "none", "name": "p-T309,S474-AKT2:PIP3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10582584", "map_id": "none", "name": "PDPK1:PIP3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54TW2", "map_id": "Q54TW2", "name": "pdkA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281471", "map_id": "DDB_G0281471", "name": "pdkA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10582586", "map_id": "none", "name": "PDPK1 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10582582", "map_id": "Q54TW2", "name": "pdkA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10583853", "map_id": "none", "name": "p-S295-PDE3B hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10583850", "map_id": "none", "name": "Homologues of p-S295-PDE3B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10605020", "map_id": "none", "name": "ATP6AP1 binds V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_10581337", "map_id": "Q557I5", "name": "ATP6AP1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "false" }, { "id": "DDB_G0273483", "map_id": "DDB_G0273483", "name": "ATP6AP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10581332", "map_id": "none", "name": "V-ATPase", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "P54647", "map_id": "P54647", "name": "vatA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287127", "map_id": "DDB_G0287127", "name": "vatA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MML6", "map_id": "Q8MML6", "name": "vatH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274553", "map_id": "DDB_G0274553", "name": "vatH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AH5", "map_id": "Q55AH5", "name": "vatF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271882", "map_id": "DDB_G0271882", "name": "vatF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86A77", "map_id": "Q86A77", "name": "atp6v1d", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274331", "map_id": "DDB_G0274331", "name": "atp6v1d", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O00780", "map_id": "O00780", "name": "vatE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275701", "map_id": "DDB_G0275701", "name": "vatE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Z13", "map_id": "Q54Z13", "name": "atp6v1g", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277971", "map_id": "DDB_G0277971", "name": "atp6v1g", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q76NU1", "map_id": "Q76NU1", "name": "vatB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277401", "map_id": "DDB_G0277401", "name": "vatB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54648", "map_id": "P54648", "name": "vatC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284473", "map_id": "DDB_G0284473", "name": "vatC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54641", "map_id": "P54641", "name": "vatD-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273071", "map_id": "DDB_G0273071", "name": "vatD-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86AS7", "map_id": "Q86AS7", "name": "ATP6V0B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274141", "map_id": "DDB_G0274141", "name": "ATP6V0B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54E04", "map_id": "Q54E04", "name": "vatM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291858", "map_id": "DDB_G0291858", "name": "vatM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54642", "map_id": "P54642", "name": "vatP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274381", "map_id": "DDB_G0274381", "name": "vatP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10581339", "map_id": "none", "name": "V-ATPase:ATP6AP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "Q557I5", "map_id": "Q557I5", "name": "ATP6AP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10581342", "map_id": "none", "name": "Endosome acidification", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17940", "compartment_display": "endosome" }, { "id": "species_74722", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171907", "compartment_display": "endosome lumen", "complex": "false" }, { "id": "reaction_10586962", "map_id": "none", "name": "PDPK1 phosphorylates AKT at T308", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10586941", "map_id": "none", "name": "p-S-AKT:PDPK1:PIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10586959", "map_id": "none", "name": "p-T,p-S-AKT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10587030", "map_id": "none", "name": "TORC2 (mTOR) phosphorylates AKT at S473", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10587009", "map_id": "none", "name": "AKT:PIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10586939", "map_id": "none", "name": "p-S-AKT:PIP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10587023", "map_id": "none", "name": "TORC2 complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O77203", "map_id": "O77203", "name": "piaA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277399", "map_id": "DDB_G0277399", "name": "piaA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9Y0C9", "map_id": "Q9Y0C9", "name": "ripA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284611", "map_id": "DDB_G0284611", "name": "ripA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10587028", "map_id": "none", "name": "AKT:PIP3:THEM4/TRIB3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10600856", "map_id": "none", "name": "PIP3 recruits PDPK1 to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10587607", "map_id": "Q54TW2", "name": "pdkA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10600858", "map_id": "none", "name": "AKT binds PDPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10604751", "map_id": "none", "name": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10604748", "map_id": "none", "name": "RASA1:p21 RAS:GTP:SPG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54Q13", "map_id": "Q54Q13", "name": "RASA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284177", "map_id": "DDB_G0284177", "name": "RASA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_428662", "map_id": "CHEBI:16393", "name": "SPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_5218688", "map_id": "CHEBI:37550", "name": "S1P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10585895", "map_id": "Q54Q13", "name": "RASA1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10604744", "map_id": "Q6B516", "name": "phospho-sgkB", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0284545", "map_id": "DDB_G0284545", "name": "sgkB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10597490", "map_id": "none", "name": "Self-ubiquitination of RNF41", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10596295", "map_id": "none", "name": "Homologues of RNF41", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q559W7", "map_id": "Q559W7", "name": "RNF41", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283193", "map_id": "DDB_G0283193", "name": "RNF41", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CL1", "map_id": "Q55CL1", "name": "RNF41", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RD2", "map_id": "Q54RD2", "name": "RNF41", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10597487", "map_id": "none", "name": "Ub-RNF41", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10599553", "map_id": "none", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_994141", "map_id": "CHEBI:16322", "name": "I(1,3,4,5,6)P5", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1629755", "map_id": "CHEBI:62928", "name": "5-PP-IP4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10599359", "map_id": "none", "name": "IP6K1/3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54B75", "map_id": "Q54B75", "name": "IP6K1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293860", "map_id": "DDB_G0293860", "name": "IP6K1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QM1", "map_id": "Q54QM1", "name": "IP6K1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XR3", "map_id": "Q54XR3", "name": "IP6K1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AP4", "map_id": "Q55AP4", "name": "IP6K1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599443", "map_id": "none", "name": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629736", "map_id": "CHEBI:62926", "name": "1-PP-IP4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1629738", "map_id": "CHEBI:62931", "name": "1,5-(PP)2-IP3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10599522", "map_id": "none", "name": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_994149", "map_id": "CHEBI:15844", "name": "I(3,4,5,6)P4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10599364", "map_id": "none", "name": "ITPK1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55D87", "map_id": "Q55D87", "name": "ITPK1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269746", "map_id": "DDB_G0269746", "name": "ITPK1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599362", "map_id": "none", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629765", "map_id": "CHEBI:30164", "name": "5-PP-IP5", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1629759", "map_id": "CHEBI:62985", "name": "5-PPP-IP5", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10599446", "map_id": "none", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629740", "map_id": "CHEBI:62919", "name": "1-PP-IP5", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1629732", "map_id": "CHEBI:62923", "name": "1,5-(PP)2-IP4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10599432", "map_id": "none", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629770", "map_id": "CHEBI:17401", "name": "IP6", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10599429", "map_id": "Q54J22", "name": "IPPK", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0288351", "map_id": "DDB_G0288351", "name": "IPPK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599370", "map_id": "none", "name": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10599562", "map_id": "none", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10597363", "map_id": "none", "name": "Activation of Ca2+ activated Potassium channels with small conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10597360", "map_id": "none", "name": "Small conductance Ca2+ activated potassium channel", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q55CX3", "map_id": "Q55CX3", "name": "KCNN3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269864", "map_id": "DDB_G0269864", "name": "KCNN3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10597350", "map_id": "none", "name": "Activation of Ca2+ activated Potassium channels with Intermediate conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10597347", "map_id": "Q55CX3", "name": "KCNN4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10597483", "map_id": "none", "name": "Activation of TALK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10597480", "map_id": "none", "name": "TALK 1and 2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10597466", "map_id": "none", "name": "Activation of TRESK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10597463", "map_id": "none", "name": "TRESK homodimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10597405", "map_id": "none", "name": "Activation of THIK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10597402", "map_id": "none", "name": "THIK1 homodimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10597455", "map_id": "none", "name": "Activation of TASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10597452", "map_id": "none", "name": "TASK", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10597434", "map_id": "none", "name": "Activation of tandem pore domain in a weak inwardly rectifying K+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10597431", "map_id": "none", "name": "TWIK channels", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10590872", "map_id": "none", "name": "GABAB heterodimeric receptor binds GABA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10589803", "map_id": "none", "name": "GABBR1:GABBR2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54F54", "map_id": "Q54F54", "name": "grlP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291095", "map_id": "DDB_G0291095", "name": "grlP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54K09", "map_id": "Q54K09", "name": "grlQ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287905", "map_id": "DDB_G0287905", "name": "grlQ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ET0", "map_id": "Q54ET0", "name": "grlE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291356", "map_id": "DDB_G0291356", "name": "grlE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_352003", "map_id": "CHEBI:59888", "name": "GABA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10589805", "map_id": "none", "name": "GABBR1:GABBR2:GABA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_916850", "map_id": "CHEBI:59888", "name": "GABA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10584963", "map_id": "none", "name": "Adenylate cyclase increases the GTPase activity of Gi alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10584931", "map_id": "none", "name": "(Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10584949", "map_id": "none", "name": "(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10584951", "map_id": "none", "name": "Dissociation of the Gi alpha:G olf complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10584933", "map_id": "none", "name": "G alpha-olf:GDP complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10584947", "map_id": "none", "name": "G-protein alpha (i):GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10584938", "map_id": "none", "name": "Adenylate cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10584935", "map_id": "none", "name": "(Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10584940", "map_id": "none", "name": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10584867", "map_id": "none", "name": "G alpha-olf:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10584929", "map_id": "none", "name": "G-protein alpha (i):GTP:Adenylate cyclase", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10583667", "map_id": "none", "name": "Formation of Exon Junction Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10579667", "map_id": "none", "name": "Magoh-Y14 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54ME8", "map_id": "Q54ME8", "name": "RBM8A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286007", "map_id": "DDB_G0286007", "name": "RBM8A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55E21", "map_id": "Q55E21", "name": "magoh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270866", "map_id": "DDB_G0270866", "name": "magoh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10579651", "map_id": "none", "name": "Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55BF5", "map_id": "Q55BF5", "name": "sf3b5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271312", "map_id": "DDB_G0271312", "name": "sf3b5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86JC5", "map_id": "Q86JC5", "name": "SF3B1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275957", "map_id": "DDB_G0275957", "name": "SF3B1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXF6", "map_id": "Q1ZXF6", "name": "sf3b2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284555", "map_id": "DDB_G0284555", "name": "sf3b2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LY9", "map_id": "Q54LY9", "name": "SF3B6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286297", "map_id": "DDB_G0286297", "name": "SF3B6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IV3", "map_id": "Q54IV3", "name": "ddx42", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288501", "map_id": "DDB_G0288501", "name": "ddx42", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SA7", "map_id": "Q54SA7", "name": "sf3b3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282569", "map_id": "DDB_G0282569", "name": "sf3b3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BG2", "map_id": "Q54BG2", "name": "SMNDC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293636", "map_id": "DDB_G0293636", "name": "SMNDC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PP4", "map_id": "Q54PP4", "name": "PHF5A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284403", "map_id": "DDB_G0284403", "name": "PHF5A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TL3", "map_id": "Q54TL3", "name": "U2SURP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281687", "map_id": "DDB_G0281687", "name": "U2SURP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CI7", "map_id": "Q55CI7", "name": "CHERP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271014", "map_id": "DDB_G0271014", "name": "CHERP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Q46", "map_id": "Q54Q46", "name": "SNRPA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284101", "map_id": "DDB_G0284101", "name": "SNRPA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54J05", "map_id": "Q54J05", "name": "snrpb2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288391", "map_id": "DDB_G0288391", "name": "snrpb2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YX5", "map_id": "Q54YX5", "name": "2xMe-SNRPD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278027", "map_id": "DDB_G0278027", "name": "2xMe-SNRPD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NC5", "map_id": "Q54NC5", "name": "snrpd2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285395", "map_id": "DDB_G0285395", "name": "snrpd2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q553B1", "map_id": "Q553B1", "name": "helB1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275443", "map_id": "DDB_G0275443", "name": "helB1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NJ4", "map_id": "Q54NJ4", "name": "dhx15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285213", "map_id": "DDB_G0285213", "name": "dhx15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BL6", "map_id": "Q55BL6", "name": "RBM17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270450", "map_id": "DDB_G0270450", "name": "RBM17", "type": "gene_component", 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"false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270020", "map_id": "DDB_G0270020", "name": "SF3A3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q557T0", "map_id": "Q557T0", "name": "cwc15-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273383", "map_id": "DDB_G0273383", "name": "cwc15-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KWK5", "map_id": "Q7KWK5", "name": "prp19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276803", "map_id": "DDB_G0276803", "name": "prp19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SG7", "map_id": "Q54SG7", "name": "spf27", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282763", "map_id": "DDB_G0282763", "name": "spf27", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WZ0", "map_id": "Q54WZ0", "name": "cdc5l", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279311", "map_id": "DDB_G0279311", "name": "cdc5l", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CN1", "map_id": "Q54CN1", "name": "WBP11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292846", "map_id": "DDB_G0292846", "name": "WBP11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WP9", "map_id": "Q54WP9", "name": "PLRG1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279507", "map_id": "DDB_G0279507", "name": "PLRG1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CT3", "map_id": "Q54CT3", "name": "CTNNBL1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292778", "map_id": "DDB_G0292778", "name": "CTNNBL1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TW32", "map_id": "Q9TW32", "name": "cypB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269120", "map_id": "DDB_G0269120", "name": "cypB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9UA41", "map_id": "Q9UA41", "name": "cypD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280401", "map_id": "DDB_G0280401", "name": "cypD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QS2", "map_id": "Q54QS2", "name": "PPIE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283663", "map_id": "DDB_G0283663", "name": "PPIE", "type": 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"inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272108", "map_id": "DDB_G0272108", "name": "DG1074", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XP4", "map_id": "Q54XP4", "name": "crnkl1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278819", "map_id": "DDB_G0278819", "name": "crnkl1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T295", "map_id": "Q8T295", "name": "prpf8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274229", "map_id": "DDB_G0274229", "name": "prpf8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ST0", "map_id": "Q54ST0", "name": "NHP2L1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282243", "map_id": "DDB_G0282243", "name": "NHP2L1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q553S5", "map_id": "Q553S5", "name": "txnl4a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275407", "map_id": "DDB_G0275407", "name": "txnl4a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55A15", "map_id": "Q55A15", "name": "PRPF6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272374", "map_id": "DDB_G0272374", "name": "PRPF6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54R72", "map_id": "Q54R72", "name": "EFTUD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283359", "map_id": "DDB_G0283359", "name": "EFTUD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AR8", "map_id": "Q55AR8", "name": "snrnp40", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271788", "map_id": "DDB_G0271788", "name": "snrnp40", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TF6", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10579612", "map_id": "Q54QF2", "name": "CWC25", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10579597", "map_id": "Q55D61", "name": "tifA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10579592", "map_id": "none", "name": "Cleavage and Polyadenylation Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10579497", "map_id": "none", "name": "Spliceosomal B Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54XH4", "map_id": "Q54XH4", "name": "USP39", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278929", "map_id": "DDB_G0278929", "name": "USP39", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TQ2", "map_id": "Q54TQ2", "name": "SART1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281621", "map_id": "DDB_G0281621", "name": "SART1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WN2", "map_id": "Q54WN2", "name": "SNRNP27", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279535", "map_id": "DDB_G0279535", "name": "SNRNP27", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54K20", "map_id": "Q54K20", "name": "PRPF4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287635", "map_id": "DDB_G0287635", "name": "PRPF4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86J17", "map_id": "Q86J17", "name": "ppiH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274281", "map_id": "DDB_G0274281", "name": "ppiH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T2A7", "map_id": "Q8T2A7", "name": "PRPF3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274213", "map_id": "DDB_G0274213", "name": "PRPF3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C7G068", "map_id": "C7G068", "name": "prpf31", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289595", "map_id": "DDB_G0289595", "name": "prpf31", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HF6", "map_id": "Q54HF6", "name": "lsm7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289499", "map_id": "DDB_G0289499", "name": "lsm7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KX4", "map_id": "Q54KX4", "name": "lsm4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287053", "map_id": "DDB_G0287053", "name": "lsm4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55EX5", "map_id": "Q55EX5", "name": "lsm5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268716", "map_id": "DDB_G0268716", "name": "lsm5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXD5", "map_id": "Q1ZXD5", "name": "lsm8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288479", "map_id": "DDB_G0288479", "name": "lsm8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXK3", "map_id": "Q1ZXK3", "name": "lsm3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277107", "map_id": "DDB_G0277107", "name": "lsm3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q552U1", "map_id": "Q552U1", "name": "lsm6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275719", "map_id": "DDB_G0275719", "name": "lsm6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YA5", "map_id": "Q54YA5", "name": "snrpC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278335", "map_id": "DDB_G0278335", "name": "snrpC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FQ0", "map_id": "Q55FQ0", "name": "snrnp70", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268004", "map_id": "DDB_G0268004", "name": "snrnp70", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LX5", "map_id": "Q54LX5", "name": "WBP4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286361", "map_id": "DDB_G0286361", "name": "WBP4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86IV3", "map_id": "Q86IV3", "name": "PRPF38A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274361", "map_id": "DDB_G0274361", "name": "PRPF38A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10579607", "map_id": "Q54GS9", "name": "GPKOW", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10579602", "map_id": "Q54MH3", "name": "dhx16", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10579617", "map_id": "Q55G43", "name": "CWC27", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0268358", "map_id": "DDB_G0268358", "name": "CWC27", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10579055", "map_id": "Q54WN2", "name": "SNRNP27", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10579002", "map_id": "none", "name": "LSM2-8 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10579050", "map_id": "Q54TQ2", "name": "SART1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10579478", "map_id": "Q54LX5", "name": "WBP4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10579623", "map_id": "none", "name": "Spliceosomal Intermediate C (Bact) Complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55G43", "map_id": "Q55G43", "name": "CWC27", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10579060", "map_id": "Q54XH4", "name": "USP39", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10579301", "map_id": "none", "name": "U1 snRNP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10578963", "map_id": "none", "name": "U4 snRNP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10579473", "map_id": "Q86IV3", "name": "PRPF38A", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10579630", "map_id": "none", "name": "Formation of the active Spliceosomal C (B*) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10581544", "map_id": "none", "name": "Formation of AT-AC C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10581540", "map_id": "none", "name": "ATAC B Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55CC1", "map_id": "Q55CC1", "name": "RNPC3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270734", "map_id": "DDB_G0270734", "name": "RNPC3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10581532", "map_id": "none", "name": "U4 ATAC snRNP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10581542", "map_id": "none", "name": "ATAC C Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10581546", "map_id": "none", "name": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10590100", "map_id": "none", "name": "cAMP activates EPAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10590096", "map_id": "none", "name": "Homologues of RAPGEF4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10590098", "map_id": "none", "name": "RAPGEF4:cAMP Complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10590135", "map_id": "none", "name": "cAMP activates EPAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10590131", "map_id": "none", "name": "Homologues of RAPGEF3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10590133", "map_id": "none", "name": "RAPGEF3:cAMP complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10590141", "map_id": "none", "name": "RAP1A exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10590137", "map_id": "none", "name": "RAP1A:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10590139", "map_id": "none", "name": "RAP1A:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10590124", "map_id": "none", "name": "ER calcium channels open in response to activated PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10590114", "map_id": "none", "name": "Ca-channel (closed)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9NA13", "map_id": "Q9NA13", "name": "iplA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292564", "map_id": "DDB_G0292564", "name": "iplA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10590122", "map_id": "none", "name": "Ca-channel (open)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10586788", "map_id": "none", "name": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_195655", "map_id": "CHEBI:27910", "name": "7dhDESOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_196420", "map_id": "CHEBI:17737", "name": "DESMOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10586785", "map_id": "Q54PP1", "name": "erg24", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0284407", "map_id": "DDB_G0284407", "name": "erg24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586760", "map_id": "none", "name": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_194691", "map_id": "CHEBI:18252", "name": "ZYMOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_195691", "map_id": "CHEBI:16290", "name": "CHdOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10586757", "map_id": "Q55E32", "name": "ebp", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0269414", "map_id": "DDB_G0269414", "name": "ebp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10627239", "map_id": "none", "name": "PM20D1 hydrolyzes oleoyl-phe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_109276", "map_id": "CHEBI:15377", "name": "H2O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_9673044", "map_id": "CHEBI:134020", "name": "oleoyl-Phe", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_351993", "map_id": "CHEBI:58095", "name": "L-Phe", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_9673048", "map_id": "CHEBI:30823", "name": "oleate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10627234", "map_id": "Q55DL1", "name": "PM20D1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "DDB_G0270582", "map_id": "DDB_G0270582", "name": "PM20D1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10627237", "map_id": "none", "name": "PM20D1 transforms oleoyl-phe from oleate and phe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10594189", "map_id": "none", "name": "SGT1 binds HSP90", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10594185", "map_id": "P54651", "name": "hspD", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10594183", "map_id": "Q55ED0", "name": "sugt1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0269292", "map_id": "DDB_G0269292", "name": "sugt1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10594187", "map_id": "none", "name": "SUGT1:HSP90", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55ED0", "map_id": "Q55ED0", "name": "sugt1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10590742", "map_id": "none", "name": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_74016", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10590739", "map_id": "none", "name": "ATP2B1-4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P54678", "map_id": "P54678", "name": "patA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277861", "map_id": "DDB_G0277861", "name": "patA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HG6", "map_id": "Q54HG6", "name": "ATP2B3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289473", "map_id": "DDB_G0289473", "name": "ATP2B3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PE8", "map_id": "Q54PE8", "name": "ATP2B3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10613009", "map_id": "none", "name": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10612993", "map_id": "none", "name": "32S pre-rRNA:Rix1:LAS1L:NOL9:SENP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q75JW2", "map_id": "Q75JW2", "name": "LAS1L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272176", "map_id": "DDB_G0272176", "name": "LAS1L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Z27", "map_id": "Q54Z27", "name": "nol9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", 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pre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoW", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10612963", "map_id": "Q75JW2", "name": "LAS1L", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10612968", "map_id": "Q54Z27", "name": "nol9", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10613007", "map_id": "none", "name": "GNL3:EBNA1BP2:DDX21:PES1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54P34", "map_id": "Q54P34", "name": "EBNA1BP2", "type": 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10613417", "map_id": "Q54VD8", "name": "rio1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0280431", "map_id": "DDB_G0280431", "name": "rio1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10613415", "map_id": "none", "name": "18SE pre-40S particle", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55BY1", "map_id": "Q55BY1", "name": "rpsA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270316", "map_id": "DDB_G0270316", "name": "rpsA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54EG3", "map_id": "Q54EG3", "name": "rps14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291526", "map_id": "DDB_G0291526", "name": "rps14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90526", "map_id": "P90526", "name": "rps3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293000", "map_id": "DDB_G0293000", "name": "rps3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": 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"complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287351", "map_id": "DDB_G0287351", "name": "DHX37", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KWM6", "map_id": "Q7KWM6", "name": "EMG1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272732", "map_id": "DDB_G0272732", "name": "EMG1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BA1", "map_id": "Q55BA1", "name": "UTP18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271240", "map_id": "DDB_G0271240", "name": "UTP18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PE0", "map_id": "Q54PE0", "name": "pwp2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284621", "map_id": "DDB_G0284621", "name": "pwp2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WN5", "map_id": "Q54WN5", "name": "utp6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279601", "map_id": "DDB_G0279601", "name": "utp6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q550V0", "map_id": "Q550V0", "name": "WDR36", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277019", "map_id": "DDB_G0277019", "name": "WDR36", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54S79", "map_id": "Q54S79", "name": "wdr3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282623", "map_id": "DDB_G0282623", "name": "wdr3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54UU6", "map_id": "Q54UU6", "name": "krr1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280805", "map_id": "DDB_G0280805", "name": "krr1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86IZ9", "map_id": "Q86IZ9", "name": "ddx52", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274325", "map_id": "DDB_G0274325", "name": "ddx52", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BV0", "map_id": "Q54BV0", "name": "RRP9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293412", "map_id": "DDB_G0293412", "name": "RRP9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CW0", "map_id": "Q55CW0", "name": "fbl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269878", "map_id": "DDB_G0269878", "name": "fbl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FI4", "map_id": "Q55FI4", "name": "nop58", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268098", "map_id": "DDB_G0268098", "name": "nop58", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MT2", "map_id": "Q54MT2", "name": "nop56", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285679", "map_id": "DDB_G0285679", "name": "nop56", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VT4", "map_id": "Q54VT4", "name": "ddx47", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280147", "map_id": "DDB_G0280147", "name": "ddx47", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54EN2", "map_id": "Q54EN2", "name": "NOL6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291438", "map_id": "DDB_G0291438", "name": "NOL6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XT8", "map_id": "Q54XT8", "name": "RRP36", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278751", "map_id": "DDB_G0278751", "name": "RRP36", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55D06", "map_id": "Q55D06", "name": "RRP7A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269830", "map_id": "DDB_G0269830", "name": "RRP7A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GG4", "map_id": "Q54GG4", "name": "PDCD11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290181", "map_id": "DDB_G0290181", "name": "PDCD11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54K79", "map_id": "Q54K79", "name": "NOP14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287537", "map_id": "DDB_G0287537", "name": "NOP14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VA5", "map_id": "Q54VA5", "name": "WDR46", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280489", "map_id": "DDB_G0280489", "name": "WDR46", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T2Q3", "map_id": "Q8T2Q3", "name": "WDR43", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275141", "map_id": "DDB_G0275141", "name": "WDR43", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55EH5", "map_id": "Q55EH5", "name": "WDR75", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268898", "map_id": "DDB_G0268898", "name": "WDR75", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QV4", "map_id": "Q54QV4", "name": "UTP15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283581", "map_id": "DDB_G0283581", "name": "UTP15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ML4", "map_id": "Q54ML4", "name": "heatr1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285875", "map_id": "DDB_G0285875", "name": "heatr1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55C50", "map_id": "Q55C50", "name": "utp11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270230", "map_id": "DDB_G0270230", "name": "utp11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10613241", "map_id": "none", "name": "18SE pre-rRNA:SSU processome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10613282", "map_id": "none", "name": "EXOSC10:C1D:MPHOSPH6:SKIV2L2:Exosome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q86IE2", "map_id": "Q86IE2", "name": "SKIV2L2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275633", "map_id": "DDB_G0275633", "name": "SKIV2L2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ZS3", "map_id": "Q54ZS3", "name": "MPHOSPH6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277279", "map_id": "DDB_G0277279", "name": "MPHOSPH6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AW0", "map_id": "Q55AW0", "name": "exosc10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271572", "map_id": "DDB_G0271572", "name": "exosc10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10613246", "map_id": "Q55AW0", "name": "exosc10", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10613265", "map_id": "Q54Q83", "name": "EXOSC5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10613280", "map_id": "Q86IE2", "name": "SKIV2L2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10613464", "map_id": "none", "name": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10613450", "map_id": "none", "name": "47S pre-rRNA:SSU processome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10613454", "map_id": "none", "name": "45S pre-rRNA:SSU processome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10613459", "map_id": "Q55CS4", "name": "XRN2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0269922", "map_id": "DDB_G0269922", "name": "XRN2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10613107", "map_id": "Q55BA1", "name": "UTP18", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10613131", "map_id": "none", "name": "UTPC complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10613462", "map_id": "Q54E37", "name": "NCL", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10613085", "map_id": "none", "name": "UTPA complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10590291", "map_id": "none", "name": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389548", "map_id": "CHEBI:151", "name": "ISCIT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389556", "map_id": "CHEBI:18009", "name": "NADP+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_193465", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389536", "map_id": "CHEBI:16526", "name": "CO2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389537", "map_id": "CHEBI:16810", "name": "2OG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_113602", "map_id": "CHEBI:16474", "name": "NADPH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10590288", "map_id": "none", "name": "IDH1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "Q75JR2", "map_id": "Q75JR2", "name": "idhM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272210", "map_id": "DDB_G0272210", "name": "idhM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617763", "map_id": "none", "name": "AKT1 dephosphorylation by PP2A-B56-beta,gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. 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For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10590479", "map_id": "none", "name": "Homologues of AKT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10617760", "map_id": "none", "name": "PP2A-B56-beta,gamma", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_1806240", "map_id": "CHEBI:16500", "name": "PI5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10598646", "map_id": "none", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10598643", "map_id": "none", "name": "PIP4K2 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10599019", "map_id": "none", "name": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_392417", "map_id": "CHEBI:17526", "name": "PI4P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10598592", "map_id": "none", "name": "PIP5K1A-C", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10611344", "map_id": "none", "name": "DCLRE1C (ARTEMIS) processes DNA DSB ends", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10608592", "map_id": "none", "name": "p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:DNA DSB ends", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54UC0", "map_id": "Q54UC0", "name": "dnapkcs", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281167", "map_id": "DDB_G0281167", "name": "dnapkcs", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MA9", "map_id": "Q54MA9", "name": "ku70", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286069", "map_id": "DDB_G0286069", "name": "ku70", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LY5", "map_id": "Q54LY5", "name": "ku80", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286303", "map_id": "DDB_G0286303", "name": "ku80", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10611341", "map_id": "none", "name": "p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:Trimmed DNA DSB ends", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10611360", "map_id": "none", "name": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10611358", "map_id": "none", "name": "p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:Ligatable DNA DSB ends", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10608604", "map_id": "none", "name": "XRCC4:LIG4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54CR9", "map_id": "Q54CR9", "name": "lig4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292760", "map_id": "DDB_G0292760", "name": "lig4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YJ7", "map_id": "Q54YJ7", "name": "xrcc4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278203", "map_id": "DDB_G0278203", "name": "xrcc4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10608613", "map_id": "Q1ZXF2", "name": "polB", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0284713", "map_id": "DDB_G0284713", "name": "polB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10608611", "map_id": "none", "name": "NHEJ1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54P54", "map_id": "Q54P54", "name": "NHEJ1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284785", "map_id": "DDB_G0284785", "name": "NHEJ1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10608617", "map_id": "none", "name": "p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Ligatable DNA DSB ends", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q1ZXF2", "map_id": "Q1ZXF2", "name": "polB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10608595", "map_id": "none", "name": "PRKDC phosphorylates DCLRE1C at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10608588", "map_id": "none", "name": "p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S645-DCLRE1C:DNA DSB ends", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10611369", "map_id": "none", "name": "DNA-PKcs autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10611366", "map_id": "none", "name": "PRKDC:XRCC5:XRCC6:DNA DSB ends", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10608586", "map_id": "none", "name": "p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:DNA DSB ends", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10611384", "map_id": "none", "name": "TDP1 and TDP2 process unligatable DSB ends", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10611381", "map_id": "none", "name": "(TDP1,TDP2)", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10611390", "map_id": "none", "name": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10611388", "map_id": "none", "name": "XRCC5:XRCC6:DNA DSBs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10611362", "map_id": "Q54UC0", "name": "dnapkcs", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10608622", "map_id": "none", "name": "POLL or POLM extends aligned DNA DSB ends to fill gaps", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10608619", "map_id": "none", "name": "p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S516,S645-DCLRE1C:XRCC4:LIG4:NHEJ1:POLL,POLM:Extended ligatable DNA DSB ends", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10599936", "map_id": "none", "name": "RAC1 and CDC42 activate PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10583374", "map_id": "none", "name": "RAC1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10590364", "map_id": "none", "name": "Homologues of PAK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10599932", "map_id": "none", "name": "RAC1:GTP,CDC42:GTP:PAK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10600039", "map_id": "none", "name": "Branching and elongation of mother and daughter filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10600037", "map_id": "none", "name": "Mother filament:ARP2/3:actin:ADP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O96626", "map_id": "O96626", "name": "arcE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288319", "map_id": "DDB_G0288319", "name": "arcE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O96622", "map_id": "O96622", "name": "arcA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277825", "map_id": "DDB_G0277825", "name": "arcA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O96623", "map_id": "O96623", "name": "arcB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282813", "map_id": "DDB_G0282813", "name": "arcB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O96624", "map_id": "O96624", "name": "arcC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292804", "map_id": "DDB_G0292804", "name": "arcC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P42528", "map_id": "P42528", "name": "arpC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283755", "map_id": "DDB_G0283755", "name": "arpC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O96625", "map_id": "O96625", "name": "arcD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269102", "map_id": "DDB_G0269102", "name": "arcD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O96621", "map_id": "O96621", "name": "arpB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272106", "map_id": "DDB_G0272106", "name": "arpB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10587698", "map_id": "none", "name": "G-actin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10599621", "map_id": "none", "name": "Mother filament:branching complex:daughter filament", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10599993", "map_id": "none", "name": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10599576", "map_id": "none", "name": "F-actin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10599989", "map_id": "none", "name": "WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q869Q3", "map_id": "Q869Q3", "name": "napA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274519", "map_id": "DDB_G0274519", "name": "napA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FT9", "map_id": "Q55FT9", "name": "phospho-abiA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267956", "map_id": "DDB_G0267956", "name": "phospho-abiA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54X65", "map_id": "Q54X65", "name": "brk1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279175", "map_id": "DDB_G0279175", "name": "brk1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6UK63", "map_id": "Q6UK63", "name": "pirA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287855", "map_id": "DDB_G0287855", "name": "pirA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10599991", "map_id": "none", "name": "Mother filament:branching complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10600666", "map_id": "none", "name": "Detachment of WASP/WAVE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10599987", "map_id": "none", "name": "WAVE2, WASP, N-WASP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10599934", "map_id": "none", "name": "Autophosphorylation of PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10592613", "map_id": "none", "name": "Homologues of p-S144,T423-PAK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10622818", "map_id": "none", "name": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10583736", "map_id": "none", "name": "Homologues of EEF1A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P0CT31", "map_id": "P0CT31", "name": "eef1a1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269134", "map_id": "DDB_G0269134", "name": "eef1a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P0CT32", "map_id": "P0CT32", "name": "eef1a2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269136", "map_id": "DDB_G0269136", "name": "eef1a2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10622810", "map_id": "none", "name": "Homologues of Me3K79-EEF1A1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10622815", "map_id": "Q86A24", "name": "N6AMT2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0272708", "map_id": "DDB_G0272708", "name": "N6AMT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622855", "map_id": "none", "name": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605038", "map_id": "P90532", "name": "cdcD", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0288065", "map_id": "DDB_G0288065", "name": "cdcD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10622843", "map_id": "P90532", "name": "cdcD", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10622852", "map_id": "none", "name": "Homologues of VCPKMT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54UI5", "map_id": "Q54UI5", "name": "VCPKMT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288643", "map_id": "DDB_G0288643", "name": "VCPKMT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IN5", "map_id": "Q54IN5", "name": "VCPKMT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622829", "map_id": "none", "name": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_77087", "map_id": "CHEBI:15414", "name": "AdoMet", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10579254", "map_id": "P36415", "name": "hspB", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_77502", "map_id": "CHEBI:16680", "name": "AdoHcy", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10622821", "map_id": "P36415", "name": "hspB", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10622826", "map_id": "Q54UI5", "name": "METTL21A", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10622877", "map_id": "none", "name": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10622869", "map_id": "none", "name": "Homologues of Me3K318-EEF1A1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10622874", "map_id": "Q54Y42", "name": "METTL10", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0278427", "map_id": "DDB_G0278427", "name": "METTL10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10588690", "map_id": "none", "name": "CYP2R1 25-hydroxylates VD3 to 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8963870", "map_id": "CHEBI:28940", "name": "VD3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_8963879", "map_id": "CHEBI:17933", "name": "25(OH)D", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10588687", "map_id": "Q1ZXF5", "name": "cyp508A4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0284535", "map_id": "DDB_G0284535", "name": "cyp508A4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586707", "map_id": "none", "name": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193829", "map_id": "CHEBI:48834", "name": "5beta-cholestan-7alpha,12alpha,27-triol-3-one", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_193843", "map_id": "CHEBI:17278", "name": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10586594", "map_id": "none", "name": "Homologues of AKR1C4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10586709", "map_id": "none", "name": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_192194", "map_id": "CHEBI:18431", "name": "Cholest-5-ene-3beta,7alpha,27-triol", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_193835", "map_id": "CHEBI:48825", "name": "4CHOL7a,27DONE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10586611", "map_id": "none", "name": "Homologues of HSD3B7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54XR1", "map_id": "Q54XR1", "name": "HSD3B7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281487", "map_id": "DDB_G0281487", "name": "HSD3B7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TU9", "map_id": "Q54TU9", "name": "HSD3B7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586711", "map_id": "none", "name": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9617026", "map_id": "CHEBI:48833", "name": "4CHOL7a,12a,27TONE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10586581", "map_id": "none", "name": "Homologues of AKR1D1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10586713", "map_id": "none", "name": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193830", "map_id": "CHEBI:48778", "name": "5beta-cholestan-7alpha,27-diol-3-one", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10586715", "map_id": "none", "name": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193842", "map_id": "CHEBI:28540", "name": "5beta-cholestan-3alpha,7alpha,26-triol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10586705", "map_id": "none", "name": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_192189", "map_id": "CHEBI:37640", "name": "CHOL7a,24(S)DIOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_193724", "map_id": "CHEBI:63838", "name": "4CHOL7a,24(S)DONE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10586697", "map_id": "none", "name": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193760", "map_id": "CHEBI:63829", "name": "5beta-cholestan-7alpha,24(S)-diol-3-one", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10586699", "map_id": "none", "name": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193745", "map_id": "CHEBI:63839", "name": "4CHOL7a,12a,24(S)TONE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_193707", "map_id": "CHEBI:63830", "name": "5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10586701", "map_id": "none", "name": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_213285", "map_id": "CHEBI:63831", "name": "5beta-cholestan-3alpha,7alpha,24(S)-triol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10586703", "map_id": "none", "name": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193728", "map_id": "CHEBI:63834", "name": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10586688", "map_id": "none", "name": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_113535", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_193442", "map_id": "CHEBI:15494", "name": "25(S) DHCA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_113575", "map_id": "CHEBI:16240", "name": "H2O2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_193459", "map_id": "CHEBI:27393", "name": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10586633", "map_id": "none", "name": "ACOX2:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "Q54GQ6", "map_id": "Q54GQ6", "name": "acox1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289993", "map_id": "DDB_G0289993", "name": "acox1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586691", "map_id": "none", "name": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_193422", "map_id": "CHEBI:52050", "name": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_192307", "map_id": "CHEBI:57540", "name": "NAD+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_192305", "map_id": "CHEBI:57945", "name": "NADH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_192339", "map_id": "CHEBI:27379", "name": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10586623", "map_id": "none", "name": "HSD17B4 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "Q54XZ0", "map_id": "Q54XZ0", "name": "mfeB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277911", "map_id": "DDB_G0277911", "name": "mfeB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586626", "map_id": "none", "name": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_141343", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_192342", "map_id": "CHEBI:27505", "name": "THCA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10586597", "map_id": "none", "name": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_193732", "map_id": "CHEBI:27403", "name": "3,7,24THCA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_193403", "map_id": "CHEBI:28533", "name": "3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10586599", "map_id": "none", "name": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_192195", "map_id": "CHEBI:28477", "name": "4CHOL7a,12aDONE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10586695", "map_id": "none", "name": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "reaction_10586614", "map_id": "none", "name": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_192114", "map_id": "CHEBI:17500", "name": "7 alpha-hydroxycholesterol", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_192136", "map_id": "CHEBI:17899", "name": "4CHOL7aOLONE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10586584", "map_id": "none", "name": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191980", "map_id": "CHEBI:2290", "name": "5beta-cholestan-7alpha-ol-3-one", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10586616", "map_id": "none", "name": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_192030", "map_id": "CHEBI:28047", "name": "5beta-cholestan-3alpha,7alpha-diol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10586636", "map_id": "none", "name": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_192316", "map_id": "CHEBI:37643", "name": "25(S) THCA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10586686", "map_id": "none", "name": "ABCB11 transports bile salts from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_193416", "map_id": "none", "name": "bile salts", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:17687", "map_id": "CHEBI:17687", "name": "CHEBI:17687", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:36274", "map_id": "CHEBI:36274", "name": "CHEBI:36274", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16525", "map_id": "CHEBI:16525", "name": "CHEBI:16525", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28865", "map_id": "CHEBI:28865", "name": "CHEBI:28865", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_193479", "map_id": "none", "name": "bile salts", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:9407", "map_id": "CHEBI:9407", "name": "CHEBI:9407", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10586683", "map_id": "none", "name": "Homologues of ABCB11", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54BT3", "map_id": "Q54BT3", "name": "abcB2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293438", "map_id": "DDB_G0293438", "name": "abcB2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T9W4", "map_id": "Q8T9W4", "name": "abcB3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291714", "map_id": "DDB_G0291714", "name": "abcB3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10620155", "map_id": "none", "name": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8868399", "map_id": "CHEBI:42977", "name": "25OH-CHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_8868400", "map_id": "CHEBI:42977", "name": "25OH-CHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10620152", "map_id": "none", "name": "OSBPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54QP6", "map_id": "Q54QP6", "name": "osbH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283709", "map_id": "DDB_G0283709", "name": "osbH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MPQ7", "map_id": "Q8MPQ7", "name": "osbA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280053", "map_id": "DDB_G0280053", "name": "osbA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86HL8", "map_id": "Q86HL8", "name": "osbE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274517", "map_id": "DDB_G0274517", "name": "osbE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RM1", "map_id": "Q54RM1", "name": "osbG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283035", "map_id": "DDB_G0283035", "name": "osbG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54EF5", "map_id": "Q54EF5", "name": "osbL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291562", "map_id": "DDB_G0291562", "name": "osbL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86HV4", "map_id": "Q86HV4", "name": "osbF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276427", "map_id": "DDB_G0276427", "name": "osbF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CR2", "map_id": "Q55CR2", "name": "osbC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269940", "map_id": "DDB_G0269940", "name": "osbC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CR3", "map_id": "Q55CR3", "name": "osbB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269938", "map_id": "DDB_G0269938", "name": "osbB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NM4", "map_id": "Q54NM4", "name": "osbJ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285141", "map_id": "DDB_G0285141", "name": "osbJ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86KG4", "map_id": "Q86KG4", "name": "osbD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272498", "map_id": "DDB_G0272498", "name": "osbD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ID7", "map_id": "Q54ID7", "name": "osbK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288817", "map_id": "DDB_G0288817", "name": "osbK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586559", "map_id": "none", "name": "Cholesterol is hydroxylated to 25-hydroxycholesterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176478", "map_id": "CHEBI:16113", "name": "CHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_192148", "map_id": "CHEBI:42977", "name": "25OH-CHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10586556", "map_id": "none", "name": "CH25H (Fe2+ cofactor)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q55D52", "map_id": "Q55D52", "name": "CH25H", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279611", "map_id": "DDB_G0279611", "name": "CH25H", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55D54", "map_id": "Q55D54", "name": "CH25H", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WK0", "map_id": "Q54WK0", "name": "CH25H", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586717", "map_id": "none", "name": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_196366", "map_id": "CHEBI:63843", "name": "pregn-5-ene-3,20-dione-17-ol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_193092", "map_id": "CHEBI:17252", "name": "17aHPROG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10586654", "map_id": "none", "name": "HSD2B1 dimer, HSD3B2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10586780", "map_id": "none", "name": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193124", "map_id": "CHEBI:28750", "name": "17aHPREG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10586657", "map_id": "none", "name": "Pregn-5-ene-3,20-dione isomerizes to progesterone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_196344", "map_id": "CHEBI:63837", "name": "pregn-5-ene-3,20-dione", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10586778", "map_id": "none", "name": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193103", "map_id": "CHEBI:16581", "name": "PREG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10586775", "map_id": "none", "name": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_196095", "map_id": "CHEBI:17998", "name": "ISCAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_196066", "map_id": "CHEBI:63910", "name": "MePeOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10627409", "map_id": "none", "name": "SRD5A3 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10603671", "map_id": "Q54PN2", "name": "SRD5A3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0284423", "map_id": "DDB_G0284423", "name": "SRD5A3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586669", "map_id": "none", "name": "HSD17B3-like proteins reducde ANDST to TEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10586666", "map_id": "none", "name": "HSD17B3-like Proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10586671", "map_id": "none", "name": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176626", "map_id": "CHEBI:28689", "name": "DHEA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10594144", "map_id": "none", "name": "HSD17B1 hydrogenates E1 to EST17b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193066", "map_id": "CHEBI:17263", "name": "E1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_193132", "map_id": "CHEBI:16469", "name": "EST17b", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10594141", "map_id": "none", "name": "HSD17B1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q556S5", "map_id": "Q556S5", "name": "HSD17B1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273855", "map_id": "DDB_G0273855", "name": "HSD17B1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10612176", "map_id": "none", "name": "AKR1B15 reduces EST17b to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113563", "map_id": "CHEBI:18009", "name": "NADP+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5696835", "map_id": "CHEBI:16469", "name": "EST17b", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5696848", "map_id": "CHEBI:17263", "name": "E1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113600", "map_id": "CHEBI:16474", "name": "NADPH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10612173", "map_id": "none", "name": "Homologues of AKR1B15", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10586465", "map_id": "none", "name": "Reduction of presqualene diphosphate to form squalene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191265", "map_id": "CHEBI:15442", "name": "PSQPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_191269", "map_id": "CHEBI:15440", "name": "SQNE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10586462", "map_id": "none", "name": "FDFT:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54DR1", "map_id": "Q54DR1", "name": "fdfT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292072", "map_id": "DDB_G0292072", "name": "fdfT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586752", "map_id": "none", "name": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_194657", "map_id": "CHEBI:63844", "name": "4CZYMOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_194661", "map_id": "CHEBI:52386", "name": "ZYMONE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10586724", "map_id": "Q54TU9", "name": "NSDHL", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10586467", "map_id": "none", "name": "Two FPP molecules dimerize to form presqualene diphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191385", "map_id": "CHEBI:17407", "name": "FAPP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10586435", "map_id": "none", "name": "Squalene 2,3-epoxide cyclizes, forming lanosterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191309", "map_id": "CHEBI:15441", "name": "SQOX", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_194634", "map_id": "CHEBI:16521", "name": "LNSOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10586432", "map_id": "Q55D85", "name": "cas1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0269226", "map_id": "DDB_G0269226", "name": "cas1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586722", "map_id": "none", "name": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_194644", "map_id": "CHEBI:17813", "name": "4,4DMCHtOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_194735", "map_id": "CHEBI:63842", "name": "4C4MZYMOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10586719", "map_id": "Q55D54", "name": "MSMO1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10586727", "map_id": "none", "name": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_194667", "map_id": "CHEBI:50593", "name": "dh4MZYMOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10586409", "map_id": "none", "name": "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191409", "map_id": "CHEBI:17211", "name": "GPP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_191362", "map_id": "CHEBI:16584", "name": "IPPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10586406", "map_id": "none", "name": "FDPS,GGPS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54BK1", "map_id": "Q54BK1", "name": "ggps1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293588", "map_id": "DDB_G0293588", "name": "ggps1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NH03", "map_id": "Q9NH03", "name": "fps", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278735", "map_id": "DDB_G0278735", "name": "fps", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586729", "map_id": "none", "name": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_194723", "map_id": "CHEBI:63841", "name": "4MZYMOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10586445", "map_id": "none", "name": "Mevalonate is phosphorylated to mevalonate-5-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191424", "map_id": "CHEBI:17710", "name": "MVA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_191296", "map_id": "CHEBI:17436", "name": "MVA5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10586442", "map_id": "none", "name": "MVK dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86AG7", "map_id": "Q86AG7", "name": "mvk", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272018", "map_id": "DDB_G0272018", "name": "mvk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586477", "map_id": "none", "name": "MVD decarboxylates MVA5PP to IPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191403", "map_id": "CHEBI:15899", "name": "MVA5PP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10586474", "map_id": "none", "name": "MVD dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54YQ9", "map_id": "Q54YQ9", "name": "mvd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278607", "map_id": "DDB_G0278607", "name": "mvd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586412", "map_id": "none", "name": "Addition of isopentenyl pyrophosphate to DMAPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191324", "map_id": "CHEBI:16057", "name": "DMAPP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10623693", "map_id": "none", "name": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8952135", "map_id": "CHEBI:134117", "name": "presqualene monophosphate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10623690", "map_id": "Q54UH9", "name": "PLPP6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0281069", "map_id": "DDB_G0281069", "name": "PLPP6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586417", "map_id": "none", "name": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191293", "map_id": "CHEBI:15345", "name": "ACA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_191374", "map_id": "CHEBI:15467", "name": "bHMG-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10586414", "map_id": "Q86HL5", "name": "hgsB", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0274871", "map_id": "DDB_G0274871", "name": "hgsB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586737", "map_id": "none", "name": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_194681", "map_id": "CHEBI:17813", "name": "4,4DMCHtOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_194725", "map_id": "CHEBI:16474", "name": "NADPH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_194688", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_194668", "map_id": "CHEBI:18009", "name": "NADP+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_194704", "map_id": "CHEBI:18364", "name": "14DMLANOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_10586734", "map_id": "Q55GJ9", "name": "AF308470", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "DDB_G0267448", "map_id": "DDB_G0267448", "name": "AF308470", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586386", "map_id": "none", "name": "Squalene is oxidized to its epoxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10586383", "map_id": "none", "name": "SQLE:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54BK7", "map_id": "Q54BK7", "name": "SQLE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293584", "map_id": "DDB_G0293584", "name": "SQLE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586455", "map_id": "none", "name": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10586452", "map_id": "none", "name": "IDI1 or 2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9NH02", "map_id": "Q9NH02", "name": "ipi", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290011", "map_id": "DDB_G0290011", "name": "ipi", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586745", "map_id": "none", "name": "CYP51A1 demethylates LNSOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29460", "map_id": "CHEBI:30751", "name": "HCOOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10586742", "map_id": "Q1ZXH9", "name": "cyp51", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0279403", "map_id": "DDB_G0279403", "name": "cyp51", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586427", "map_id": "none", "name": "HMGCR dimer reduces bHMG-CoA to MVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10586424", "map_id": "none", "name": "HMGCR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "P34135", "map_id": "P34135", "name": "hmgA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269142", "map_id": "DDB_G0269142", "name": "hmgA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10616679", "map_id": "none", "name": "EBP isomerizes ZYMSTNL to LTHSOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_6807048", "map_id": "CHEBI:16608", "name": "ZYMSTNL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_6807054", "map_id": "CHEBI:17168", "name": "LTHSOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10616681", "map_id": "none", "name": "DHCR7 reduces 7-dehydroCHOL to CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_6807057", "map_id": "CHEBI:17759", "name": "7-dehydroCHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_193384", "map_id": "CHEBI:16113", "name": "CHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10604925", "map_id": "none", "name": "ARV1 transports CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_171095", "map_id": "CHEBI:16113", "name": "CHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10604922", "map_id": "Q54GD9", "name": "arv1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0290221", "map_id": "DDB_G0290221", "name": "arv1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586750", "map_id": "none", "name": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_194633", "map_id": "CHEBI:18364", "name": "14DMLANOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10586747", "map_id": "Q55GJ9", "name": "AF308470", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10580109", "map_id": "none", "name": "Formation of eIF2:GDP:eIF2B intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10580105", "map_id": "none", "name": "eIF2B subunits complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54I81", "map_id": "Q54I81", "name": "eif2b1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288961", "map_id": "DDB_G0288961", "name": "eif2b1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RF3", "map_id": "Q54RF3", "name": "eif2b5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283163", "map_id": "DDB_G0283163", "name": "eif2b5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FQ8", "map_id": "Q54FQ8", "name": "eif2b3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290693", "map_id": "DDB_G0290693", "name": "eif2b3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54EY2", "map_id": "Q54EY2", "name": "eif2b2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291271", "map_id": "DDB_G0291271", "name": "eif2b2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FM3", "map_id": "Q54FM3", "name": "eif2b4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290759", "map_id": "DDB_G0290759", "name": "eif2b4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10580049", "map_id": "none", "name": "eIF2:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54XD8", "map_id": "Q54XD8", "name": "eif2s3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278967", "map_id": "DDB_G0278967", "name": "eif2s3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q869N9", "map_id": "Q869N9", "name": "eif2s1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271862", "map_id": "DDB_G0271862", "name": "eif2s1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54T27", "map_id": "Q54T27", "name": "eif2s2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282035", "map_id": "DDB_G0282035", "name": "eif2s2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10580107", "map_id": "none", "name": "eIF2:GDP: eIF2B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10580399", "map_id": "none", "name": "eIF2 activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10580004", "map_id": "none", "name": "eIF2:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10616599", "map_id": "none", "name": "CK2 binds FACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10583211", "map_id": "none", "name": "FACT complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54G78", "map_id": "Q54G78", "name": "ssrp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290331", "map_id": "DDB_G0290331", "name": "ssrp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54S43", "map_id": "Q54S43", "name": "spt16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282677", "map_id": "DDB_G0282677", "name": "spt16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10616595", "map_id": "none", "name": "Casein kinase II", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10616597", "map_id": "none", "name": "CK2:FACT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10603956", "map_id": "none", "name": "SUMOylation of NOP58 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10601786", "map_id": "none", "name": "SUMO2:UBE2I", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54SX2", "map_id": "Q54SX2", "name": "UBE2I-G92-SUMO3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282161", "map_id": "DDB_G0282161", "name": "UBE2I-G92-SUMO3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10603928", "map_id": "Q55FI4", "name": "nop58", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10603953", "map_id": "Q55FI4", "name": "nop58", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10603944", "map_id": "none", "name": "SUMOylation of NOP58 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10603942", "map_id": "none", "name": "2SUMO1:NOP58", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10583553", "map_id": "none", "name": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_114521", "compartment_display": "platelet dense tubular network membrane" }, { "id": "species_139827", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_114580", "compartment_display": "platelet dense tubular network lumen", "complex": "false" }, { "id": "species_10583550", "map_id": "none", "name": "IP3R tetramer:I(1,4,5)P3:4xCa2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114521", "compartment_display": "platelet dense tubular network membrane", "complex": "true" }, { "id": "reaction_10598400", "map_id": "none", "name": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1605716", "map_id": "CHEBI:18313", "name": "Gb3Cer", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1605601", "map_id": "CHEBI:17950", "name": "LacCer", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10598397", "map_id": "none", "name": "GLA dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q54EG4", "map_id": "Q54EG4", "name": "GLA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291524", "map_id": "DDB_G0291524", "name": "GLA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55B10", "map_id": "Q55B10", "name": "melA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271490", "map_id": "DDB_G0271490", "name": "melA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598437", "map_id": "none", "name": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_429807", "map_id": "CHEBI:17761", "name": "CERA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1606609", "map_id": "CHEBI:16393", "name": "SPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1861754", "map_id": "CHEBI:33575", "name": "RCOOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10598434", "map_id": "none", "name": "ASAH2-like proteins", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10598343", "map_id": "none", "name": "Beta-galactosidase hydrolyses GM1 to GM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1605677", "map_id": "CHEBI:61048", "name": "GM1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "species_1605610", "map_id": "CHEBI:51013", "name": "GM2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "reaction_10598425", "map_id": "none", "name": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_429776", "map_id": "CHEBI:17636", "name": "SPHM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1610735", "map_id": "CHEBI:18132", "name": "ChoP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10598422", "map_id": "none", "name": "SMPD2,3:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q86IG2", "map_id": "Q86IG2", "name": "SMPD3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288017", "map_id": "DDB_G0288017", "name": "SMPD3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXD9", "map_id": "Q1ZXD9", "name": "SMPD3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598408", "map_id": "none", "name": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1605713", "map_id": "CHEBI:17636", "name": "SPHM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1605750", "map_id": "CHEBI:18132", "name": "ChoP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1605673", "map_id": "CHEBI:52639", "name": "CERA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10598405", "map_id": "Q54C16", "name": "sgmB", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "DDB_G0293210", "map_id": "DDB_G0293210", "name": "sgmB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598427", "map_id": "none", "name": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1605592", "map_id": "CHEBI:18368", "name": "Glucosylceramide", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10599629", "map_id": "none", "name": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_1861782", "map_id": "CHEBI:18368", "name": "Glucosylceramide", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10599626", "map_id": "Q54D71", "name": "GBA2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0292446", "map_id": "DDB_G0292446", "name": "GBA2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598508", "map_id": "none", "name": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10598505", "map_id": "Q54MJ8", "name": "ENPP7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10598383", "map_id": "none", "name": "Both hexosaminidase A and B can cleave GalNAc from globoside", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1605608", "map_id": "CHEBI:61360", "name": "Globoside", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1605658", "map_id": "CHEBI:28037", "name": "GalNAc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10598380", "map_id": "none", "name": "HEXA,B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q54K55", "map_id": "Q54K55", "name": "hexb1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287597", "map_id": "DDB_G0287597", "name": "hexb1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SC9", "map_id": "Q54SC9", "name": "hexa2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282539", "map_id": "DDB_G0282539", "name": "hexa2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54K56", "map_id": "Q54K56", "name": "hexb2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287659", "map_id": "DDB_G0287659", "name": "hexb2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MU9", "map_id": "Q54MU9", "name": "HEXA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285647", "map_id": "DDB_G0285647", "name": "HEXA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P13723", "map_id": "P13723", "name": "hexa1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287033", "map_id": "DDB_G0287033", "name": "hexa1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10605541", "map_id": "none", "name": "ATP2B4 binds to NOS1, inhibiting it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10590737", "map_id": "none", "name": "Homologues of ATP2B4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10605539", "map_id": "none", "name": "ATP2B4:NOS1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10595189", "map_id": "none", "name": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10595116", "map_id": "none", "name": "p-IRAK2:oligo-TRAF6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10595186", "map_id": "none", "name": "p-IRAK2:K63-linked pUb oligo-TRAF6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10595191", "map_id": "none", "name": "IRAK2 induces TRAF6 oligomerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10595114", "map_id": "none", "name": "TRAF6:p-IRAK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10595194", "map_id": "none", "name": "Activated TRAF6 synthesizes unanchored polyubiquitin chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10595760", "map_id": "none", "name": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10595757", "map_id": "none", "name": "p-IRAK2:oligo-TRAF6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10595762", "map_id": "none", "name": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10595755", "map_id": "none", "name": "TRAF6:p-IRAK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10584367", "map_id": "none", "name": "Association of LBP with LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10584361", "map_id": "none", "name": "Homologues of LBP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q54JE8", "map_id": "Q54JE8", "name": "LBP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288097", "map_id": "DDB_G0288097", "name": "LBP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BA2", "map_id": "Q55BA2", "name": "BPI", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271242", "map_id": "DDB_G0271242", "name": "BPI", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JE7", "map_id": "Q54JE7", "name": "LBP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_166005", "map_id": "CHEBI:16412", "name": "LPS", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10584363", "map_id": "none", "name": "LBP:bacterial LPS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10584365", "map_id": "Q55BA2", "name": "BPI", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10616640", "map_id": "none", "name": "HMGB1 release from cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10589181", "map_id": "Q55C24", "name": "nhp6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0270260", "map_id": "DDB_G0270260", "name": "nhp6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10616549", "map_id": "Q55C24", "name": "nhp6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10616553", "map_id": "none", "name": "HMGB1 binds LTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_181015", "map_id": "CHEBI:28640", "name": "Lipoteichoic acid", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10616551", "map_id": "none", "name": "HC23,45-HMGB1:LTA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q55C24", "map_id": "Q55C24", "name": "nhp6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10620682", "map_id": "none", "name": "oxPL binds LBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_2186967", "map_id": "CHEBI:60156", "name": "oxidized phospholipids", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10620680", "map_id": "none", "name": "LBP:oxPL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10616557", "map_id": "none", "name": "HMGB1 binds LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10616555", "map_id": "none", "name": "HC23,45-HMGB1:LPS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10625430", "map_id": "none", "name": "RHOT1 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10625411", "map_id": "none", "name": "RHOT1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q55G45", "map_id": "Q55G45", "name": "gemA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267830", "map_id": "DDB_G0267830", "name": "gemA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10625426", "map_id": "none", "name": "Homologues of MYO19", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q9U1M8", "map_id": "Q9U1M8", "name": "myoI", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274455", "map_id": "DDB_G0274455", "name": "myoI", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54696", "map_id": "P54696", "name": "myoH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289447", "map_id": "DDB_G0289447", "name": "myoH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TW28", "map_id": "Q9TW28", "name": "myoM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292262", "map_id": "DDB_G0292262", "name": "myoM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54697", "map_id": "P54697", "name": "myoJ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272112", "map_id": "DDB_G0272112", "name": "myoJ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10625428", "map_id": "none", "name": "RHOT1:GTP:RHOT1 effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10625416", "map_id": "none", "name": "RHOT1 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10625413", "map_id": "none", "name": "RHOT1:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10607623", "map_id": "none", "name": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5687536", "map_id": "CHEBI:85309", "name": "isoAsp", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5687529", "map_id": "CHEBI:31882", "name": "MetAsp", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10607620", "map_id": "Q9GPS6", "name": "pcmA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0280979", "map_id": "DDB_G0280979", "name": "pcmA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10627360", "map_id": "none", "name": "APC/C:Cdh1 polyubiquitinates SKP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10627357", "map_id": "none", "name": "RB1:SKP2:APC/C:Cdh1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10585955", "map_id": "none", "name": "PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10585442", "map_id": "none", "name": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10585356", "map_id": "none", "name": "cell cycle proteins:phospho-APC/C:Cdh1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54WX4", "map_id": "Q54WX4", "name": "aurK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279343", "map_id": "DDB_G0279343", "name": "aurK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10585371", "map_id": "none", "name": "multiubiquitinated cell cycle protein:APC/C:Cdh1 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10585957", "map_id": "none", "name": "APC/C:Cdh1-mediated degradation of Skp2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10585327", "map_id": "none", "name": "26S proteasome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10585373", "map_id": "none", "name": "Degradation of multiubiquitinated cell cycle proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10585358", "map_id": "none", "name": "Association of cell cycle proteins with the APC/C:Cdh1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10585354", "map_id": "none", "name": "(APC/C:Cdh1)-targeted cell cycle proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10585448", "map_id": "none", "name": "SCF-mediated degradation of Emi1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10585434", "map_id": "none", "name": "SCF-associated multiubiquitinated Emi1complexes", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10585446", "map_id": "none", "name": "Cdc20/Cdh1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10585428", "map_id": "none", "name": "BTRC:CUL1:SKP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10585437", "map_id": "none", "name": "Ubiquitination of Emi1 by SCF-beta-TrCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10585432", "map_id": "none", "name": "SCF-beta-TrCP:phospho-Emi1 complexes", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10585961", "map_id": "none", "name": "Association of Cyclin A:Cdk2 with Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10583654", "map_id": "none", "name": "Binding of the MCC complex to the APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10583650", "map_id": "none", "name": "hBUBR1:hBUB3:MAD2*:CDC20 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54CV5", "map_id": "Q54CV5", "name": "bub1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292676", "map_id": "DDB_G0292676", "name": "bub1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q556Y9", "map_id": "Q556Y9", "name": "mad2l1-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273201", "map_id": "DDB_G0273201", "name": "mad2l1-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DM1", "map_id": "Q54DM1", "name": "bub3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292134", "map_id": "DDB_G0292134", "name": "bub3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10583652", "map_id": "none", "name": "MCC:APC/C complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10583660", "map_id": "none", "name": "Formation of the MCC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10583638", "map_id": "Q54DM1", "name": "bub3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10583648", "map_id": "Q556Y9", "name": "mad2l1-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10583633", "map_id": "Q54CV5", "name": "bub1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10583658", "map_id": "none", "name": "Inactivation of APC/C via CDC20 sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10583656", "map_id": "none", "name": "MAD2*CDC20 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10585343", "map_id": "none", "name": "Phosphorylation of Cdh1 by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10585390", "map_id": "none", "name": "Dissociation of phospho-Cdh1 from the APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10585236", "map_id": "none", "name": "phospho-Cdh1:phospho-APC/C complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10585192", "map_id": "Q54KM3", "name": "phospho-cdh1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10585234", "map_id": "none", "name": "phosphorylated anaphase promoting complex (APC/C)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10585458", "map_id": "none", "name": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10585456", "map_id": "none", "name": "hBUBR1:hBUB3:MAD2* complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10585452", "map_id": "none", "name": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10585411", "map_id": "none", "name": "Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10585413", "map_id": "none", "name": "multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10585369", "map_id": "none", "name": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10585364", "map_id": "none", "name": "Cdc2:Cyclin A:MCC:APC/C complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10585366", "map_id": "none", "name": "multiubiquitinated Cyclin A associated with MCC:APC/C complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10585888", "map_id": "none", "name": "Multiubiquitination of Nek2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10585881", "map_id": "none", "name": "Nek2A:MCC:APC/C complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55BN8", "map_id": "Q55BN8", "name": "nek2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270814", "map_id": "DDB_G0270814", "name": "nek2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10585885", "map_id": "none", "name": "Multiubiquitinated Nek2A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10585890", "map_id": "none", "name": "Degradation of multiubiquitinated Nek2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10585883", "map_id": "none", "name": "Association of Nek2A with MCC:APC/C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10585879", "map_id": "Q55BN8", "name": "nek2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10585444", "map_id": "none", "name": "Degradation of multiubiquitinated Securin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10585398", "map_id": "none", "name": "CDC20:pAPC/C:K11polyUb-PTTG1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10585401", "map_id": "none", "name": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10585394", "map_id": "none", "name": "CDC20:p-APC/C:PTTG1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10585384", "map_id": "none", "name": "Free APC/C phosphorylated by Plk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10585330", "map_id": "none", "name": "Degradation of multiubiquitinated Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10585238", "map_id": "none", "name": "multiubiquitinated Cdh1 associated with APC/C", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10585241", "map_id": "none", "name": "Multiubiquitination of APC/C-associated Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10598791", "map_id": "none", "name": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_172574", "compartment_display": "late endosome membrane" }, { "id": "species_1806198", "map_id": "CHEBI:17283", "name": "PI3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_172574", "compartment_display": "late endosome membrane", "complex": "false" }, { "id": "species_1806195", "map_id": "CHEBI:16749", "name": "PI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_172574", "compartment_display": "late endosome membrane", "complex": "false" }, { "id": "species_10598788", "map_id": "none", "name": "MTM1,MTMR2,MTMR4,MTMR7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10599016", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_172574", "compartment_display": "late endosome membrane" }, { "id": "species_1806289", "map_id": "CHEBI:16851", "name": "PI(3,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_172574", "compartment_display": "late endosome membrane", "complex": "false" }, { "id": "species_1806212", "map_id": "CHEBI:16500", "name": "PI5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_172574", "compartment_display": "late endosome membrane", "complex": "false" }, { "id": "reaction_10599004", "map_id": "none", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_172574", "compartment_display": "late endosome membrane" }, { "id": "species_10598879", "map_id": "none", "name": "PIK3C2A/3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54S78", "map_id": "Q54S78", "name": "PIK3C2A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282625", "map_id": "DDB_G0282625", "name": "PIK3C2A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FX5", "map_id": "Q55FX5", "name": "PIK3C2A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54673", "map_id": "P54673", "name": "pikA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278727", "map_id": "DDB_G0278727", "name": "pikA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54674", "map_id": "P54674", "name": "pikB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283081", "map_id": "DDB_G0283081", "name": "pikB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54675", "map_id": "P54675", "name": "pikC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275011", "map_id": "DDB_G0275011", "name": "pikC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599088", "map_id": "none", "name": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_1524146", "map_id": "CHEBI:16749", "name": "PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_1806217", "map_id": "CHEBI:17526", "name": "PI4P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10598801", "map_id": "Q54ZN9", "name": "PI4KA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0277537", "map_id": "DDB_G0277537", "name": "PI4KA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599059", "map_id": "none", "name": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10599048", "map_id": "Q55AW9", "name": "sac1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "DDB_G0271630", "map_id": "DDB_G0271630", "name": "sac1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598871", "map_id": "none", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_1806230", "map_id": "CHEBI:16152", "name": "PI(3,4)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10598868", "map_id": "none", "name": "PIK3C2A/G", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10599081", "map_id": "none", "name": "PI4KB binds to ARF1/3:GTP at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10599079", "map_id": "none", "name": "Homologues of PI4KB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P54677", "map_id": "P54677", "name": "pikD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288485", "map_id": "DDB_G0288485", "name": "pikD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LR9", "map_id": "Q54LR9", "name": "PI4KB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286479", "map_id": "DDB_G0286479", "name": "PI4KB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10598835", "map_id": "none", "name": "ARF1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "O00909", "map_id": "O00909", "name": "arfA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289173", "map_id": "DDB_G0289173", "name": "arfA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Y34", "map_id": "Q54Y34", "name": "ARF1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292332", "map_id": "DDB_G0292332", "name": "ARF1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXA5", "map_id": "Q1ZXA5", "name": "ARF1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YV7", "map_id": "Q54YV7", "name": "arrL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278057", "map_id": "DDB_G0278057", "name": "arrL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HK2", "map_id": "Q54HK2", "name": "arrF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289435", "map_id": "DDB_G0289435", "name": "arrF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AR1", "map_id": "Q55AR1", "name": "arrC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271792", "map_id": "DDB_G0271792", "name": "arrC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JJ3", "map_id": "Q54JJ3", "name": "arrH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288015", "map_id": "DDB_G0288015", "name": "arrH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SH9", "map_id": "Q54SH9", "name": "arrA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282457", "map_id": "DDB_G0282457", "name": "arrA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54V41", "map_id": "Q54V41", "name": "arrK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280633", "map_id": "DDB_G0280633", "name": "arrK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54V47", "map_id": "Q54V47", "name": "arrJ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280621", "map_id": "DDB_G0280621", "name": "arrJ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VB0", "map_id": "Q54VB0", "name": "arrE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280479", "map_id": "DDB_G0280479", "name": "arrE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10598837", "map_id": "none", "name": "ARF1/3:GTP:PI4KB", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10598809", "map_id": "none", "name": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_1806165", "map_id": "CHEBI:18348", "name": "PI(4,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10598806", "map_id": "Q8I7P3", "name": "Dd5P4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0267462", "map_id": "DDB_G0267462", "name": "Dd5P4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598840", "map_id": "none", "name": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "reaction_10599051", "map_id": "none", "name": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_1806159", "map_id": "CHEBI:17283", "name": "PI3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10599115", "map_id": "none", "name": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10599112", "map_id": "none", "name": "TPTE2-like proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q54MG8", "map_id": "Q54MG8", "name": "TPTE2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285967", "map_id": "DDB_G0285967", "name": "TPTE2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598911", "map_id": "none", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "reaction_10599056", "map_id": "none", "name": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1806234", "map_id": "CHEBI:17526", "name": "PI4P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10599053", "map_id": "Q55AW9", "name": "sac1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10598804", "map_id": "none", "name": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10617403", "map_id": "none", "name": "PI3P is dephosphorylated to PI by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10617398", "map_id": "none", "name": "MTMR2:SBF1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10617400", "map_id": "none", "name": "SBF1 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10598734", "map_id": "none", "name": "Homologues of MTMR2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10617396", "map_id": "none", "name": "Homologues of SBF1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10617406", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6809774", "map_id": "CHEBI:16851", "name": "PI(3,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_422529", "map_id": "CHEBI:16500", "name": "PI5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10599073", "map_id": "none", "name": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_202247", "map_id": "CHEBI:16152", "name": "PI(3,4)P2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10587224", "map_id": "Q8T9S7", "name": "pteN", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0286557", "map_id": "DDB_G0286557", "name": "phospho-pteN", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598595", "map_id": "none", "name": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10599043", "map_id": "none", "name": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10599040", "map_id": "none", "name": "PIK3(2)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54DK0", "map_id": "Q54DK0", "name": "PIK3R6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292252", "map_id": "DDB_G0292252", "name": "PIK3R6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617313", "map_id": "none", "name": "MTMR8 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10617309", "map_id": "none", "name": "Homologues of MTMR9", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10617283", "map_id": "Q54C52", "name": "MTMR8", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10617311", "map_id": "none", "name": "MTMR8:MTMR9", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10598914", "map_id": "none", "name": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_426658", "map_id": "CHEBI:16749", "name": "PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10598818", "map_id": "none", "name": "SYNJs,OCRL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8I7P3", "map_id": "Q8I7P3", "name": "Dd5P4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54D97", "map_id": "Q54D97", "name": "Dd5P3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292392", "map_id": "DDB_G0292392", "name": "Dd5P3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599013", "map_id": "none", "name": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10599010", "map_id": "none", "name": "PIK3C(1)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10598821", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_1806224", "map_id": "CHEBI:16851", "name": "PI(3,5)P2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1806276", "map_id": "CHEBI:17283", "name": "PI3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10598796", "map_id": "none", "name": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10598793", "map_id": "none", "name": "PIP5K1A/B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10599086", "map_id": "none", "name": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10599083", "map_id": "none", "name": "SYNJ/INPP5(1)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54PV1", "map_id": "Q54PV1", "name": "Dd5P2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284187", "map_id": "DDB_G0284187", "name": "Dd5P2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54W40", "map_id": "Q54W40", "name": "INPP5J", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279927", "map_id": "DDB_G0279927", "name": "INPP5J", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617325", "map_id": "none", "name": "MTMR6 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10598992", "map_id": "none", "name": "Homologues of MTMR6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10617323", "map_id": "none", "name": "MTMR6:MTMR9", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10617330", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10617327", "map_id": "none", "name": "MTMR6:MTMR9,MTMR8:MTMR9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10599091", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10598999", "map_id": "none", "name": "MTM1,MTMR1,MTMR3,MTMR6,MTMR14,SYNJ1,SYNJ2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10617333", "map_id": "none", "name": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10599062", "map_id": "none", "name": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10587227", "map_id": "none", "name": "PTEN dephosphorylates PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10599002", "map_id": "none", "name": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10598909", "map_id": "none", "name": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10598906", "map_id": "none", "name": "INPP5(2)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10599070", "map_id": "none", "name": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10599067", "map_id": "none", "name": "PIP4K2/5K1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10618317", "map_id": "none", "name": "ENPP6 hydrolyzes lysophosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_2239407", "map_id": "CHEBI:60479", "name": "lysophosphatidylcholine", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_6814794", "map_id": "CHEBI:18132", "name": "ChoP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_6814795", "map_id": "CHEBI:17408", "name": "MAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10618314", "map_id": "Q54MJ8", "name": "ENPP6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10598240", "map_id": "none", "name": "PC:PITPNB is transported from the Golgi membrane to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10598146", "map_id": "none", "name": "PC:PITPNB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9NCL8", "map_id": "Q9NCL8", "name": "pitA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290069", "map_id": "DDB_G0290069", "name": "pitA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10598238", "map_id": "none", "name": "PC:PITPNB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10598259", "map_id": "none", "name": "PI:PITPNB is transported from the ER membrane to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10598242", "map_id": "none", "name": "PI:PITPNB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10598144", "map_id": "none", "name": "PI:PITPNB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10598148", "map_id": "none", "name": "PI is exchanged with PC by PITPNB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "reaction_10599024", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_1806259", "map_id": "CHEBI:16500", "name": "PI5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "species_10599021", "map_id": "none", "name": "MTM1,MTMR2,MTMR4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10617363", "map_id": "none", "name": "MTMR12 binds MTM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10617359", "map_id": "none", "name": "Homologues of MTMR12", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10598708", "map_id": "none", "name": "Homologues of MTM1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10617361", "map_id": "none", "name": "MTM1:MTMR12", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10598882", "map_id": "none", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_1806199", "map_id": "CHEBI:16749", "name": "PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "reaction_10617367", "map_id": "none", "name": "MTMR12 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10617365", "map_id": "none", "name": "MTMR2:MTMR12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10618629", "map_id": "none", "name": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8849959", "map_id": "none", "name": "PI(4,5)P2, PI(3,4)P2, PI(3,4,5)P3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "species_1806238", "map_id": "CHEBI:16152", "name": "PI(3,4)P2", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_8849958", "map_id": "none", "name": "PI5P, PI3P, PI(3,5)P2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "species_10618626", "map_id": "none", "name": "Homologues of INPP5F", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "Q86HL0", "map_id": "Q86HL0", "name": "INPP5F", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290653", "map_id": "DDB_G0290653", "name": "INPP5F", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AW9", "map_id": "Q55AW9", "name": "sac1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FY6", "map_id": "Q54FY6", "name": "INPP5F", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599065", "map_id": "none", "name": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "reaction_10617370", "map_id": "none", "name": "PI3P is dephosphorylated to PI by MTM1:MTMR12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "reaction_10599118", "map_id": "none", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_1806180", "map_id": "CHEBI:17526", "name": "PI4P", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10598854", "map_id": "none", "name": "PIK3C2A:Ca2+/Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10598208", "map_id": "none", "name": "PC is hydrolyzed to PA and choline by PLD1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_264618", "map_id": "CHEBI:15354", "name": "Cho", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10598205", "map_id": "none", "name": "PLD1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54WR4", "map_id": "Q54WR4", "name": "pldB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279483", "map_id": "DDB_G0279483", "name": "pldB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Z25", "map_id": "Q54Z25", "name": "pldC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277949", "map_id": "DDB_G0277949", "name": "pldC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Q49", "map_id": "Q54Q49", "name": "PLD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284155", "map_id": "DDB_G0284155", "name": "PLD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54UK0", "map_id": "Q54UK0", "name": "pldA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281031", "map_id": "DDB_G0281031", "name": "pldA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10612690", "map_id": "none", "name": "DDHD1,2 hydrolyse PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1602448", "map_id": "CHEBI:16337", "name": "PA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1602447", "map_id": "CHEBI:16975", "name": "1-acyl LPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1602366", "map_id": "CHEBI:57560", "name": "LCFA(-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10612687", "map_id": "none", "name": "DDHD1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86KP6", "map_id": "Q86KP6", "name": "PITPNM3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276935", "map_id": "DDB_G0276935", "name": "PITPNM3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54EA5", "map_id": "Q54EA5", "name": "SEC23IP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291694", "map_id": "DDB_G0291694", "name": "SEC23IP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DN9", "map_id": "Q55DN9", "name": "PITPNM3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DP0", "map_id": "Q55DP0", "name": "PITPNM3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10594009", "map_id": "none", "name": "G3P is acylated to 1-acyl LPA by AGPAT6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_76114", "map_id": "CHEBI:15978", "name": "G3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1500604", "map_id": "CHEBI:16975", "name": "1-acyl LPA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10581703", "map_id": "Q554U0", "name": "AGPAT6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0274969", "map_id": "DDB_G0274969", "name": "AGPAT9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10623946", "map_id": "none", "name": "PLD6 dimer hydrolyses cardiolipin to PA and PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_189422", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_8954419", "map_id": "CHEBI:28494", "name": "cardiolipin", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_8954401", "map_id": "CHEBI:17517", "name": "PG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_1500590", "map_id": "CHEBI:16337", "name": "PA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10623943", "map_id": "none", "name": "PLD6 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q54TK6", "map_id": "Q54TK6", "name": "PLD6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281695", "map_id": "DDB_G0281695", "name": "PLD6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10585976", "map_id": "none", "name": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_188458", "map_id": "CHEBI:15978", "name": "G3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_188451", "map_id": "CHEBI:57642", "name": "DHAP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10585973", "map_id": "Q54QC1", "name": "GPD2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0283951", "map_id": "DDB_G0283951", "name": "GPD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10597949", "map_id": "none", "name": "1-acyl LPA is acylated to PA by AGPAT5 (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_1500580", "map_id": "CHEBI:16975", "name": "1-acyl LPA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10597946", "map_id": "Q54IT8", "name": "AGPAT5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "DDB_G0288523", "map_id": "DDB_G0288523", "name": "LPGAT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622766", "map_id": "none", "name": "ACP6 hydrolyses MYS-LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_8878649", "map_id": "CHEBI:62833", "name": "MYS-LPA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_8934414", "map_id": "CHEBI:75562", "name": "1-MMG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10622763", "map_id": "Q54PR9", "name": "cf60", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0284363", "map_id": "DDB_G0284363", "name": "cf60", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10581726", "map_id": "none", "name": "1-acyl LPA is acylated to PA by AGPAT (LPAAT)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10581723", "map_id": "none", "name": "AGPAT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54IT8", "map_id": "Q54IT8", "name": "LPGAT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CZ2", "map_id": "Q55CZ2", "name": "LPGAT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54EU4", "map_id": "Q54EU4", "name": "AGPAT2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q554U0", "map_id": "Q554U0", "name": "AGPAT9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IG1", "map_id": "Q54IG1", "name": "AGPAT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10611940", "map_id": "none", "name": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_5696449", "map_id": "CHEBI:17408", "name": "MAG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_6782195", "map_id": "CHEBI:17984", "name": "Acyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10598028", "map_id": "none", "name": "DAG is acylated to TAG by DGAT1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1500594", "map_id": "CHEBI:17855", "name": "TAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10598025", "map_id": "none", "name": "DGAT1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q55BH9", "map_id": "Q55BH9", "name": "dgat1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271342", "map_id": "DDB_G0271342", "name": "dgat1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GC1", "map_id": "Q54GC1", "name": "dgat2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10618492", "map_id": "none", "name": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10618487", "map_id": "Q54GC1", "name": "dgat2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10598017", "map_id": "none", "name": "MLCL is acylated to CL by LCLAT1 (ER)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1524069", "map_id": "CHEBI:60430", "name": "MLCL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_1524081", "map_id": "CHEBI:28494", "name": "CL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10581717", "map_id": "none", "name": "Homologues of LCLAT1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10598019", "map_id": "none", "name": "DLCL is acylated to MLCL by LCLAT1 (ER)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1524080", "map_id": "CHEBI:60431", "name": "DLCL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10597996", "map_id": "none", "name": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_1524075", "map_id": "CHEBI:16110", "name": "PC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_1498773", "map_id": "CHEBI:60430", "name": "MLCL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_1524072", "map_id": "CHEBI:28494", "name": "cardiolipin", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_1524079", "map_id": "CHEBI:17504", "name": "1-acyl LPC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10597993", "map_id": "Q54DX7", "name": "taz", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0291922", "map_id": "DDB_G0291922", "name": "taz", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598012", "map_id": "none", "name": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_1524083", "map_id": "CHEBI:16038", "name": "PE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_1524089", "map_id": "CHEBI:29017", "name": "1-acyl LPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "reaction_10605155", "map_id": "none", "name": "CPNEs bind PL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10605151", "map_id": "none", "name": "CPNEs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54P51", "map_id": "Q54P51", "name": "cpnC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284791", "map_id": "DDB_G0284791", "name": "cpnC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GG1", "map_id": "Q55GG1", "name": "cpnD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267688", "map_id": "DDB_G0267688", "name": "cpnD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXB3", "map_id": "Q1ZXB3", "name": "cpnF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291498", "map_id": "DDB_G0291498", "name": "cpnF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FY7", "map_id": "Q54FY7", "name": "cpnE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290529", "map_id": "DDB_G0290529", "name": "cpnE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7YXU4", "map_id": "Q7YXU4", "name": "cpnA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293008", "map_id": "DDB_G0293008", "name": "cpnA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86K21", "map_id": "Q86K21", "name": "cpnB-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272875", "map_id": "DDB_G0272875", "name": "cpnB-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_171142", "map_id": "CHEBI:16247", "name": "PL", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10605153", "map_id": "none", "name": "CPNEs:PL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10598166", "map_id": "none", "name": "PA is converted to CDP-DAG by CDS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_426955", "map_id": "CHEBI:17962", "name": "CDP-DAG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10598163", "map_id": "none", "name": "CDS1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q55D90", "map_id": "Q55D90", "name": "cdsA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269742", "map_id": "DDB_G0269742", "name": "cdsA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598092", "map_id": "none", "name": "CDP-DAG is converted to PI by CDIPT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_426910", "map_id": "CHEBI:17268", "name": "Ins", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10598089", "map_id": "none", "name": "CDIPT:Mg2+/Mn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54P27", "map_id": "Q54P27", "name": "CDIPT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284857", "map_id": "DDB_G0284857", "name": "CDIPT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10620477", "map_id": "none", "name": "PITPNM1,2,3 exchange PI for PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10620474", "map_id": "none", "name": "PITPNM1,2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9NCL7", "map_id": "Q9NCL7", "name": "pitB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274579", "map_id": "DDB_G0274579", "name": "pitB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54D93", "map_id": "Q54D93", "name": "pitD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292426", "map_id": "DDB_G0292426", "name": "pitD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VC7", "map_id": "Q54VC7", "name": "pitE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280449", "map_id": "DDB_G0280449", "name": "pitE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598213", "map_id": "none", "name": "PC is converted to PS by PTDSS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_200736", "map_id": "CHEBI:33384", "name": "L-Ser", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1500646", "map_id": "CHEBI:18303", "name": "PS", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10598210", "map_id": "Q1ZXJ3", "name": "pssA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0278159", "map_id": "DDB_G0278159", "name": "pssA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598156", "map_id": "none", "name": "PE is converted to PS by PTDSS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10598153", "map_id": "Q1ZXJ3", "name": "pssA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10598171", "map_id": "none", "name": "PA is converted to CDP-DAG by CDS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_1524101", "map_id": "CHEBI:16337", "name": "PA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_110577", "map_id": "CHEBI:17677", "name": "CTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_1524064", "map_id": "CHEBI:17962", "name": "CDP-DAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10598168", "map_id": "Q55D90", "name": "cdsA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "reaction_10619810", "map_id": "none", "name": "MFSD2A transports LPC from extracellular region to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_8865642", "map_id": "CHEBI:64567", "name": "LPC (22:6)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_74113", "map_id": "CHEBI:29101", "name": "Na+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_8865629", "map_id": "CHEBI:64567", "name": "LPC (22:6)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_83910", "map_id": "CHEBI:29101", "name": "Na+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10619807", "map_id": "Q54SX3", "name": "MFSD2A", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0282159", "map_id": "DDB_G0282159", "name": "MFSD2A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598179", "map_id": "none", "name": "PE is methylated to PC by PEMT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10598176", "map_id": "Q54SD5", "name": "pemtA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0282527", "map_id": "DDB_G0282527", "name": "pemtA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598082", "map_id": "none", "name": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_1524057", "map_id": "CHEBI:17815", "name": "DAG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_1524060", "map_id": "CHEBI:16436", "name": "CDP-Cho", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10598079", "map_id": "none", "name": "CHPT1:Mg2+/Mn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10611829", "map_id": "none", "name": "ABHD3 hydrolyses LPC(14:0) to 1AGPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_5694502", "map_id": "CHEBI:64483", "name": "LPC(14:0)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_5694457", "map_id": "CHEBI:11230", "name": "1AGPC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10611826", "map_id": "none", "name": "Homologues of ABHD3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q55C73", "map_id": "Q55C73", "name": "ABHD3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270192", "map_id": "DDB_G0270192", "name": "ABHD3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54H38", "map_id": "Q54H38", "name": "abhd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289723", "map_id": "DDB_G0289723", "name": "abhd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10589593", "map_id": "none", "name": "AcCho is hydrolyzed to Cho and acetate by ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_372533", "map_id": "CHEBI:15355", "name": "AcCho", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_1524044", "map_id": "CHEBI:30089", "name": "acetate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_264638", "map_id": "CHEBI:15354", "name": "Cho", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10589588", "map_id": "none", "name": "Homologues of ACHE", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54ET7", "map_id": "Q54ET7", "name": "CES3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291344", "map_id": "DDB_G0291344", "name": "CES3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86L18", "map_id": "Q86L18", "name": "CES3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P18142", "map_id": "P18142", "name": "D2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283085", "map_id": "DDB_G0283085", "name": "D2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54N21", "map_id": "Q54N21", "name": "CES3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WD8", "map_id": "Q54WD8", "name": "CES3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P21837", "map_id": "P21837", "name": "cryS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285419", "map_id": "DDB_G0285419", "name": "cryS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10589591", "map_id": "none", "name": "ACHE:ACHEIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10598121", "map_id": "none", "name": "Cho is phosphorylated to PCho by CHK dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1524071", "map_id": "CHEBI:36700", "name": "PCho", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10598118", "map_id": "none", "name": "CHK dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10598137", "map_id": "none", "name": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10598134", "map_id": "none", "name": "PCYT1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54GD2", "map_id": "Q54GD2", "name": "PCYT1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290229", "map_id": "DDB_G0290229", "name": "PCYT1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598058", "map_id": "none", "name": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10598055", "map_id": "none", "name": "CEPT1:Mg2+/Mn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10592589", "map_id": "none", "name": "Cho transports from the extracellular space to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10592586", "map_id": "none", "name": "CTL1-5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54I48", "map_id": "Q54I48", "name": "slc44a2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289013", "map_id": "DDB_G0289013", "name": "slc44a2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IJ2", "map_id": "Q54IJ2", "name": "SLC44A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288717", "map_id": "DDB_G0288717", "name": "SLC44A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10597968", "map_id": "none", "name": "2-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498730", "map_id": "CHEBI:27923", "name": "2-acyl LPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_1483256", "map_id": "CHEBI:17517", "name": "PG", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10597938", "map_id": "none", "name": "LPGAT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10597941", "map_id": "none", "name": "1-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498740", "map_id": "CHEBI:62747", "name": "1-acyl LPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10597985", "map_id": "none", "name": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498750", "map_id": "CHEBI:16870", "name": "GPCho", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10597962", "map_id": "none", "name": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10597954", "map_id": "none", "name": "1-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498733", "map_id": "CHEBI:28914", "name": "1-acyl LPI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10597951", "map_id": "Q54XX2", "name": "MBOAT7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10598010", "map_id": "none", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[11]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10597965", "map_id": "none", "name": "2-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498737", "map_id": "CHEBI:62746", "name": "2-acyl LPI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10598021", "map_id": "none", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498738", "map_id": "CHEBI:29017", "name": "1-acyl LPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10598023", "map_id": "none", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10597980", "map_id": "none", "name": "2-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498729", "map_id": "CHEBI:28936", "name": "2-acyl LPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10597977", "map_id": "none", "name": "LPEAT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10597983", "map_id": "none", "name": "1-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10597988", "map_id": "none", "name": "2-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498722", "map_id": "CHEBI:37646", "name": "2-acyl LPS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10597972", "map_id": "none", "name": "LPSAT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10597975", "map_id": "none", "name": "1-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498724", "map_id": "CHEBI:52603", "name": "1-acyl LPS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10620264", "map_id": "none", "name": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_33625", "map_id": "CHEBI:18303", "name": "PS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10620261", "map_id": "none", "name": "OSBPL5,8,10", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10601149", "map_id": "none", "name": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1598585", "compartment_display": "chromosome" }, { "id": "species_2537690", "map_id": "none", "name": "Chromatin", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_1598585", "compartment_display": "chromosome", "complex": "false" }, { "id": "species_10601101", "map_id": "none", "name": "Cohesin:PDS5:WAPAL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54QR0", "map_id": "Q54QR0", "name": "phospho-p-STAG2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283681", "map_id": "DDB_G0283681", "name": "phospho-p-STAG2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54E85", "map_id": "Q54E85", "name": "smc1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291752", "map_id": "DDB_G0291752", "name": "smc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q552D9", "map_id": "Q552D9", "name": "smc3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276101", "map_id": "DDB_G0276101", "name": "smc3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q550H7", "map_id": "Q550H7", "name": "phospho-p-S454-RAD21", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276977", "map_id": "DDB_G0276977", "name": "phospho-p-S454-RAD21", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q552Q7", "map_id": "Q552Q7", "name": "pds5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275929", "map_id": "DDB_G0275929", "name": "pds5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10601141", "map_id": "none", "name": "NIPBL:MAU2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54RK7", "map_id": "Q54RK7", "name": "NIPBL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283099", "map_id": "DDB_G0283099", "name": "NIPBL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54S35", "map_id": "Q54S35", "name": "MAU2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282689", "map_id": "DDB_G0282689", "name": "MAU2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10601147", "map_id": "none", "name": "Cohesin:PDS5:WAPAL:NIPBL:MAU2:Chromatin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10626171", "map_id": "none", "name": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_9619052", "map_id": "none", "name": "ACEI pro-drugs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_8878776", "map_id": "CHEBI:30879", "name": "Alcohol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_9619021", "map_id": "none", "name": "hydrolysed ACEIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10611415", "map_id": "none", "name": "CES1 trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10582448", "map_id": "none", "name": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10582444", "map_id": "none", "name": "Homologues of SLBP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54J82", "map_id": "Q54J82", "name": "SLBP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288225", "map_id": "DDB_G0288225", "name": "SLBP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q75J91", "map_id": "Q75J91", "name": "SLBP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10582446", "map_id": "none", "name": "Capped Intronless Histone pre-mRNA:CBP80:CBP20:SLBP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10582469", "map_id": "none", "name": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10582467", "map_id": "none", "name": "Capped Intronless Histone pre-mRNA:CBP80:CBP20:SLBP:ZFP100 Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10582473", "map_id": "none", "name": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10582471", "map_id": "none", "name": "Mature Intronless transcript derived Histone mRNA:SLBP:CBP80:CBP20", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10600404", "map_id": "none", "name": "PGH2 is reduced to PGF2a by AKR1C3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_265283", "map_id": "CHEBI:15554", "name": "PGH2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_879535", "map_id": "CHEBI:15553", "name": "PGF2a", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10589015", "map_id": "none", "name": "Prostaglandin E synthase isomerizes PGH2 to PGE2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_265287", "map_id": "CHEBI:15551", "name": "PGE2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10600407", "map_id": "none", "name": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_879629", "map_id": "CHEBI:15555", "name": "PGD2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2142710", "map_id": "CHEBI:27595", "name": "11epi-PGF2a", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10583842", "map_id": "none", "name": "salicylic acid + Coenzyme A + ATP => salicylate-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_159559", "map_id": "CHEBI:16914", "name": "SAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_159557", "map_id": "CHEBI:32587", "name": "Salicylate-CoA thioester", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10583839", "map_id": "none", "name": "ACSM2B-like proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q8SSN6", "map_id": "Q8SSN6", "name": "ACSM5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276337", "map_id": "DDB_G0276337", "name": "ACSM5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q551W4", "map_id": "Q551W4", "name": "ACSM5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10585793", "map_id": "none", "name": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_177153", "map_id": "CHEBI:8082", "name": "phenylacetate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_177137", "map_id": "CHEBI:15537", "name": "phenylacetyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10583822", "map_id": "none", "name": "xenobiotic/medium-chain fatty acid:CoA ligases", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10583825", "map_id": "none", "name": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_159446", "map_id": "CHEBI:30746", "name": "BENZA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_159447", "map_id": "CHEBI:15515", "name": "BEZ-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10625238", "map_id": "none", "name": "RHOBTB1 binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10625234", "map_id": "none", "name": "Homologues of RHOBTB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "Q54HZ7", "map_id": "Q54HZ7", "name": "racM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289103", "map_id": "DDB_G0289103", "name": "racM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23862", "map_id": "Q23862", "name": "racE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280975", "map_id": "DDB_G0280975", "name": "racE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YY4", "map_id": "Q54YY4", "name": "racN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278009", "map_id": "DDB_G0278009", "name": "racN", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54N82", "map_id": "Q54N82", "name": "RHOBTB1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285453", "map_id": "DDB_G0285453", "name": "RHOBTB1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GPQ9", "map_id": "Q9GPQ9", "name": "racJ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292560", "map_id": "DDB_G0292560", "name": "racJ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GPQ8", "map_id": "Q9GPQ8", "name": "racL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292816", "map_id": "DDB_G0292816", "name": "racL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GPS0", "map_id": "Q9GPS0", "name": "racG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269178", "map_id": "DDB_G0269178", "name": "racG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GPR7", "map_id": "Q9GPR7", "name": "racH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269240", "map_id": "DDB_G0269240", "name": "racH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O96390", "map_id": "O96390", "name": "racF1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269176", "map_id": "DDB_G0269176", "name": "racF1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GPS3", "map_id": "Q9GPS3", "name": "racF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276967", "map_id": "DDB_G0276967", "name": "racF2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34146", "map_id": "P34146", "name": "rac1C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282365", "map_id": "DDB_G0282365", "name": "rac1C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34145", "map_id": "P34145", "name": "rac1B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268622", "map_id": "DDB_G0268622", "name": "rac1B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34149", "map_id": "P34149", "name": "racC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293526", "map_id": "DDB_G0293526", "name": "racC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34148", "map_id": "P34148", "name": "racB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279605", "map_id": "DDB_G0279605", "name": "racB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXJ6", "map_id": "Q1ZXJ6", "name": "racQ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278011", "map_id": "DDB_G0278011", "name": "racQ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34150", "map_id": "P34150", "name": "racD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291976", "map_id": "DDB_G0291976", "name": "racD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10625236", "map_id": "none", "name": "RHOBTB1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10625269", "map_id": "none", "name": "RHOBTB1 binds interacting proteins at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10625265", "map_id": "none", "name": "RHOBTB1 interacting proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10625267", "map_id": "none", "name": "RHOBTB1:GTP:RHOBTB1 interacting proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10625322", "map_id": "none", "name": "RHOBTB2 binds interacting proteins at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10625307", "map_id": "none", "name": "RHOBTB2:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "species_10625318", "map_id": "none", "name": "RHOBTB2 interacting proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10625320", "map_id": "none", "name": "RHOBTB2:GTP:RHOBTB2 interacting proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10625366", "map_id": "none", "name": "RHOV binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10625360", "map_id": "none", "name": "RHOV:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10625362", "map_id": "none", "name": "RHOV effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10625364", "map_id": "none", "name": "RHOV:GTP:RHOV effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10625370", "map_id": "none", "name": "RHOV binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10625368", "map_id": "none", "name": "RHOV:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10627382", "map_id": "none", "name": "RAC1 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10605813", "map_id": "none", "name": "RHOA,RHOG,RAC1,CDC42:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10624907", "map_id": "none", "name": "RAC1 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10624903", "map_id": "none", "name": "RAC1 effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54WW0", "map_id": "Q54WW0", "name": "NISCH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290421", "map_id": "DDB_G0290421", "name": "NISCH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54G40", "map_id": "Q54G40", "name": "NISCH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q867X6", "map_id": "Q867X6", "name": "cybA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267460", "map_id": "DDB_G0267460", "name": "cybA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86GL4", "map_id": "Q86GL4", "name": "noxB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287101", "map_id": "DDB_G0287101", "name": "noxB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54F44", "map_id": "Q54F44", "name": "noxC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291117", "map_id": "DDB_G0291117", "name": "noxC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q867T7", "map_id": "Q867T7", "name": "ncfA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288773", "map_id": "DDB_G0288773", "name": "ncfA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54I34", "map_id": "Q54I34", "name": "IQGAP3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289033", "map_id": "DDB_G0289033", "name": "IQGAP3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54K32", "map_id": "Q54K32", "name": "rgaA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287585", "map_id": "DDB_G0287585", "name": "rgaA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O00899", "map_id": "O00899", "name": "gapA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269140", "map_id": "DDB_G0269140", "name": "gapA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XYS3", "map_id": "Q9XYS3", "name": "noxA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289653", "map_id": "DDB_G0289653", "name": "noxA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10624905", "map_id": "none", "name": "RAC1:GTP:RAC1 effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10624927", "map_id": "none", "name": "RAC1 GDIs block activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10599930", "map_id": "none", "name": "RAC1:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10624923", "map_id": "none", "name": "ARHGDIA,ARHGDIB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q95UP9", "map_id": "Q95UP9", "name": "rdiB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280049", "map_id": "DDB_G0280049", "name": "rdiB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95UQ1", "map_id": "Q95UQ1", "name": "rdiA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291077", "map_id": "DDB_G0291077", "name": "rdiA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10624925", "map_id": "none", "name": "RAC1:GDP:RAC1 GDIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10624700", "map_id": "none", "name": "RAC1 GEFs activate RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10624697", "map_id": "none", "name": "RAC1 GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54LN3", "map_id": "Q54LN3", "name": "Q54LN3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286543", "map_id": "DDB_G0286543", "name": "Q54LN3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BQ8", "map_id": "Q55BQ8", "name": "DOCK4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292004", "map_id": "DDB_G0292004", "name": "DOCK4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DS6", "map_id": "Q54DS6", "name": "docA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291974", "map_id": "DDB_G0291974", "name": "docA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DW1", "map_id": "Q54DW1", "name": "DOCK4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PB7", "map_id": "Q54PB7", "name": "DOCK4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SG9", "map_id": "Q54SG9", "name": "TIAM1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282475", "map_id": "DDB_G0282475", "name": "TIAM1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BV5", "map_id": "Q54BV5", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293396", "map_id": "DDB_G0293396", "name": "FGD5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YP1", "map_id": "Q54YP1", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XW8", "map_id": "Q54XW8", "name": "gxcII", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278703", "map_id": "DDB_G0278703", "name": "gxcII", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54C56", "map_id": "Q54C56", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DL8", "map_id": "Q55DL8", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BY9", "map_id": "Q54BY9", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YZ6", "map_id": "Q54YZ6", "name": "racgef1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277987", "map_id": "DDB_G0277987", "name": "racgef1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54F88", "map_id": "Q54F88", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86HN1", "map_id": "Q86HN1", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DW7", "map_id": "Q54DW7", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55G61", "map_id": "Q55G61", "name": "gxcGG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268354", "map_id": "DDB_G0268354", "name": "gxcGG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GP2", "map_id": "Q54GP2", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54G10", "map_id": "Q54G10", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86K95", "map_id": "Q86K95", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NG0", "map_id": "Q54NG0", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54J14", "map_id": "Q54J14", "name": "gxcH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288377", "map_id": "DDB_G0288377", "name": "gxcH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54P81", "map_id": "Q54P81", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54P24", "map_id": "Q54P24", "name": "grfA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284845", "map_id": "DDB_G0284845", "name": "grfA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SR5", "map_id": "Q54SR5", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54S15", "map_id": "Q54S15", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XA7", "map_id": "Q54XA7", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VX2", "map_id": "Q54VX2", "name": "FGD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10624829", "map_id": "none", "name": "RAC1 GAPs stimulate RAC1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10624826", "map_id": "none", "name": "RAC1 GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54BP9", "map_id": "Q54BP9", "name": "gacV", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293510", "map_id": "DDB_G0293510", "name": "gacV", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXE1", "map_id": "Q1ZXE1", "name": "gacM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287895", "map_id": "DDB_G0287895", "name": "gacM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54E35", "map_id": "Q54E35", "name": "gacEE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291840", "map_id": "DDB_G0291840", "name": "gacEE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BF1", "map_id": "Q54BF1", "name": "gacE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293654", "map_id": "DDB_G0293654", "name": "gacE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86B03", "map_id": "Q86B03", "name": "ARHGAP12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276833", "map_id": "DDB_G0276833", "name": "ARHGAP12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PG5", "map_id": "Q54PG5", "name": "gacC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284571", "map_id": "DDB_G0284571", "name": "gacC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FG5", "map_id": "Q54FG5", "name": "gacJJ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290873", "map_id": "DDB_G0290873", "name": "gacJJ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86I31", "map_id": "Q86I31", "name": "gacFF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275085", "map_id": "DDB_G0275085", "name": "gacFF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XE8", "map_id": "Q54XE8", "name": "gacP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279009", "map_id": "DDB_G0279009", "name": "gacP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q553X3", "map_id": "Q553X3", "name": "gacI", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275185", "map_id": "DDB_G0275185", "name": "gacI", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MV3", "map_id": "Q54MV3", "name": "gacJ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285641", "map_id": "DDB_G0285641", "name": "gacJ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86IG9", "map_id": "Q86IG9", "name": "gacH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272694", "map_id": "DDB_G0272694", "name": "gacH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10624960", "map_id": "none", "name": "RAC2 GDIs block activation of RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10624954", "map_id": "none", "name": "RAC2:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10624919", "map_id": "none", "name": "Homologues of ARHGDIA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10624958", "map_id": "none", "name": "ARHGDIA:RAC2:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10624982", "map_id": "none", "name": "RAC2 translocates to the phagocytic vesicle membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10583458", "map_id": "none", "name": "RAC2:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10606729", "map_id": "none", "name": "RAC2:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222693", "compartment_display": "phagocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10627542", "map_id": "none", "name": "RAC2 translocates to the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10627524", "map_id": "none", "name": "RAC2:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10624980", "map_id": "none", "name": "RAC2 GEFs activate RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10624977", "map_id": "none", "name": "RAC2 GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10627540", "map_id": "none", "name": "RAC2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10627536", "map_id": "none", "name": "RAC2 mitochondrial effectors", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10627538", "map_id": "none", "name": "RAC2:GTP:RAC2 mitochondrial effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10624970", "map_id": "none", "name": "RAC2 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10624966", "map_id": "none", "name": "RAC2 plasma membrane effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10624968", "map_id": "none", "name": "RAC2:GTP:RAC2 cytosolic effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10624975", "map_id": "none", "name": "RAC2 GAPs stimulate RAC2 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10624972", "map_id": "none", "name": "RAC2 GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54FF4", "map_id": "Q54FF4", "name": "gacL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290891", "map_id": "DDB_G0290891", "name": "gacL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8SSN9", "map_id": "Q8SSN9", "name": "gacF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274243", "map_id": "DDB_G0274243", "name": "gacF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TH9", "map_id": "Q54TH9", "name": "gacY", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281739", "map_id": "DDB_G0281739", "name": "gacY", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XT6", "map_id": "Q54XT6", "name": "gacR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278755", "map_id": "DDB_G0278755", "name": "gacR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54J98", "map_id": "Q54J98", "name": "gacX", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288205", "map_id": "DDB_G0288205", "name": "gacX", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DW9", "map_id": "Q55DW9", "name": "gacZ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269496", "map_id": "DDB_G0269496", "name": "gacZ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ND2", "map_id": "Q54ND2", "name": "ARHGAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285391", "map_id": "DDB_G0285391", "name": "ARHGAP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10627580", "map_id": "none", "name": "RAC2 translocates to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10627578", "map_id": "none", "name": "RAC2:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10625394", "map_id": "none", "name": "RAC3 GDIs block activation of RAC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10625388", "map_id": "none", "name": "RAC3 GDIs", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10625374", "map_id": "none", "name": "RAC3:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P34147", "map_id": "P34147", "name": "racA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286555", "map_id": "DDB_G0286555", "name": "racA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10625392", "map_id": "none", "name": "RAC3:GDP:RAC3 GDIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10627586", "map_id": "none", "name": "RAC3 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10625376", "map_id": "none", "name": "RAC3:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10627584", "map_id": "none", "name": "RAC3:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10625381", "map_id": "none", "name": "RAC3 GEFs activate RAC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10625378", "map_id": "none", "name": "RAC3 GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10625386", "map_id": "none", "name": "RAC3 GAPs stimulate RAC3 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10625383", "map_id": "none", "name": "RAC3 GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10625404", "map_id": "none", "name": "RAC3 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10625400", "map_id": "none", "name": "RAC3 effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10625402", "map_id": "none", "name": "RAC3:GTP:RAC3 effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10625193", "map_id": "none", "name": "RHOU binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10625189", "map_id": "none", "name": "RHOU effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10625172", "map_id": "none", "name": "RHOU:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10625191", "map_id": "none", "name": "RHOU:GTP:RHOU effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10625198", "map_id": "none", "name": "RHOU auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10625195", "map_id": "none", "name": "RHOU:GDP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10625079", "map_id": "none", "name": "RHOH binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10625063", "map_id": "none", "name": "Homologues of RHOH", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10625065", "map_id": "none", "name": "RHOH:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10625077", "map_id": "none", "name": "GDIs bind RHOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10625073", "map_id": "none", "name": "ARHGDIA,ARHGDIB,ARHGDIG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10625075", "map_id": "none", "name": "RHOH:GTP:RHOH GDIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10625134", "map_id": "none", "name": "RHOH binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10625130", "map_id": "none", "name": "RHOH effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10625132", "map_id": "none", "name": "RHOH:GTP:RHOH effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10605858", "map_id": "none", "name": "IQGAPs bind CALM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10605847", "map_id": "none", "name": "RAC1,CDC42:GTP:IQGAPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10587556", "map_id": "none", "name": "CALM1:4Ca2+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10605853", "map_id": "none", "name": "RAC1:GTP,CDC42:GTP:IQGAPs:CALM1:4Ca2+", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10605849", "map_id": "none", "name": "GTP-bound RAC1 and CDC42 bind IQGAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605845", "map_id": "none", "name": "IQGAP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10605855", "map_id": "none", "name": "IQGAPs bind F-actin, which is inhibited by calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605851", "map_id": "none", "name": "RAC1,CDC42:GTP:IQGAP:F-actin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10606803", "map_id": "none", "name": "PAK2 phosphorylates myosin regulatory light chain (MRLC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10606794", "map_id": "none", "name": "Smooth muscle/non-muscle myosin II", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P08799", "map_id": "P08799", "name": "mhcA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286355", "map_id": "DDB_G0286355", "name": "mhcA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P09402", "map_id": "P09402", "name": "mlcE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277859", "map_id": "DDB_G0277859", "name": "mlcE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P13833", "map_id": "P13833", "name": "phospho-mlcR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276077", "map_id": "DDB_G0276077", "name": "phospho-mlcR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10606800", "map_id": "none", "name": "p-T19-MRLC-Smooth muscle/non-muscle myosin II", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10605892", "map_id": "none", "name": "Homologues of p-S141,T402-PAK2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10624235", "map_id": "none", "name": "RAC1 and CDC42 activate PAK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10590382", "map_id": "none", "name": "PAK3 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10590380", "map_id": "Q55GV3", "name": "pakC", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10605872", "map_id": "none", "name": "CDC42:GTP,RAC1:GTP:PAK3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10605901", "map_id": "none", "name": "Autophosphorylation of PAK1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605874", "map_id": "none", "name": "CDC42:GTP,RAC1:GTP:PAK1,PAK2,PAK3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10605898", "map_id": "none", "name": "p-S,T-PAK1,2,3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10624237", "map_id": "none", "name": "RAC1 and CDC42 activate PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10590378", "map_id": "none", "name": "PAK2 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10605870", "map_id": "none", "name": "CDC42:GTP,RAC1:GTP:PAK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10590376", "map_id": "none", "name": "Homologues of PAK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10606784", "map_id": "none", "name": "NOX3 complex:RAC1:GTP generates superoxide from oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_352327", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_3299686", "map_id": "CHEBI:18421", "name": "O2.-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10606781", "map_id": "none", "name": "NOX3 complex:RAC1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10606786", "map_id": "none", "name": "RAC1:GTP binds NOX3 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10606779", "map_id": "none", "name": "NOX3 Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10606759", "map_id": "none", "name": "RAC1:GTP binds NOX1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10606755", "map_id": "none", "name": "NOX1 Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10606757", "map_id": "none", "name": "NOX1 complex:RAC1:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10606762", "map_id": "none", "name": "NOX1 complex:RAC1:GTP generates superoxide from oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10613711", "map_id": "none", "name": "PIK3C3:PIK3R4 phosphorylates PI to PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1222693", "compartment_display": "phagocytic vesicle membrane" }, { "id": "species_1524165", "map_id": "CHEBI:16749", "name": "PI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1629751", "map_id": "CHEBI:17283", "name": "PI3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10613708", "map_id": "none", "name": "PIK3C3:PIK3R4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222693", "compartment_display": "phagocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10627463", "map_id": "none", "name": "RHOBTB3 binds interacting proteins at trans-Golgi network", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10627457", "map_id": "none", "name": "RHOBTB3:ATP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "species_10627459", "map_id": "none", "name": "RHOBTB3 interacting proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q1ZXB7", "map_id": "Q1ZXB7", "name": "rabK2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290791", "map_id": "DDB_G0290791", "name": "rabK2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54K69", "map_id": "Q54K69", "name": "rab7B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287553", "map_id": "DDB_G0287553", "name": "rab7B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P36411", "map_id": "P36411", "name": "rab7A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269236", "map_id": "DDB_G0269236", "name": "rab7A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FK8", "map_id": "Q54FK8", "name": "rabM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290829", "map_id": "DDB_G0290829", "name": "rabM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXB9", "map_id": "Q1ZXB9", "name": "rabK3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290831", "map_id": "DDB_G0290831", "name": "rabK3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXB8", "map_id": "Q1ZXB8", "name": "RAB9A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0294571", "map_id": "DDB_G0294571", "name": "RAB9A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q552H0", "map_id": "Q552H0", "name": "RAB9A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FK4", "map_id": "Q54FK4", "name": "rabK1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290833", "map_id": "DDB_G0290833", "name": "rabK1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FK2", "map_id": "Q54FK2", "name": "rabN2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290793", "map_id": "DDB_G0290793", "name": "rabN2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FK7", "map_id": "Q54FK7", "name": "rabL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290779", "map_id": "DDB_G0290779", "name": "rabL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FK5", "map_id": "Q54FK5", "name": "rabN1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290789", "map_id": "DDB_G0290789", "name": "rabN1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10627461", "map_id": "none", "name": "RHOBTB3:ATP:RHOBTB3 interacting proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10627465", "map_id": "none", "name": "RHOBTB3 binds ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10627455", "map_id": "none", "name": "Homologues of RHOBTB3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10627470", "map_id": "none", "name": "RHOBTB3 hydrolyzes ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10627467", "map_id": "none", "name": "RHOBTB3:ADP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10625434", "map_id": "none", "name": "RHOT2 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10625432", "map_id": "none", "name": "RHOT2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10588961", "map_id": "none", "name": "Autoubiquitination of phospho-COP1(Ser-387 )", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10588954", "map_id": "Q54IY4", "name": "phospho-p-S387-RFWD2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10588958", "map_id": "none", "name": "ubiquitinated phospho-COP1(ser-387)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10588963", "map_id": "none", "name": "Proteasome mediated degradation of COP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10588956", "map_id": "none", "name": "Translocation of COP1 from the nucleus to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10588952", "map_id": "Q54IY4", "name": "phospho-p-S387-RFWD2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10591483", "map_id": "none", "name": "eNoSC deacetylates histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10591466", "map_id": "none", "name": "Chromatin with acetylated H3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O15819", "map_id": "O15819", "name": "H3a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267402", "map_id": "DDB_G0267402", "name": "H3a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_427498", "map_id": "CHEBI:76279", "name": "2'-O-acetyl-ADP-ribose", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10588889", "map_id": "none", "name": "Chromatin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10591480", "map_id": "none", "name": "eNoSC", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54CP1", "map_id": "Q54CP1", "name": "rrp8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292960", "map_id": "DDB_G0292960", "name": "rrp8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GV7", "map_id": "Q54GV7", "name": "sir2D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289967", "map_id": "DDB_G0289967", "name": "sir2D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10591486", "map_id": "none", "name": "eNoSC dimethylates histone H3 at lysine-9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10581485", "map_id": "none", "name": "Chromatin (H3K9me2)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10596528", "map_id": "none", "name": "Transfer of Ub from E2 to substrate and release of E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10596521", "map_id": "none", "name": "Ag-substrate:E3:E2:Ub", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54ZG5", "map_id": "Q54ZG5", "name": "RNF144B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277577", "map_id": "DDB_G0277577", "name": "RNF144B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q75JS0", "map_id": "Q75JS0", "name": "ZNRF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272202", "map_id": "DDB_G0272202", "name": "ZNRF2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54E43", "map_id": "Q54E43", "name": "RNF213", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291812", "map_id": "DDB_G0291812", "name": "RNF213", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q557Q0", "map_id": "Q557Q0", "name": "RNF213", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GE4", "map_id": "Q55GE4", "name": "RNF213", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FZ8", "map_id": "Q54FZ8", "name": "RNF213", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q557G6", "map_id": "Q557G6", "name": "RNF213", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C7G038", "map_id": "C7G038", "name": "RNF213", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JE9", "map_id": "Q54JE9", "name": "UBR2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292128", "map_id": "DDB_G0292128", "name": "UBR2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QZ3", "map_id": "Q54QZ3", "name": "UBR2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q75JM9", "map_id": "Q75JM9", "name": "UBR2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DM4", "map_id": "Q54DM4", "name": "UBR2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JT8", "map_id": "Q54JT8", "name": "UBR2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JV0", "map_id": "Q54JV0", "name": "UBR2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IW6", "map_id": "Q54IW6", "name": "UBR2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LZ6", "map_id": "Q54LZ6", "name": "RNF19B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286289", "map_id": "DDB_G0286289", "name": "RNF19B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AE0", "map_id": "Q55AE0", "name": "RNF19A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285763", "map_id": "DDB_G0285763", "name": "RNF19A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MZ0", "map_id": "Q54MZ0", "name": "RNF19A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PV3", "map_id": "Q54PV3", "name": "RNF19A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TL7", "map_id": "Q54TL7", "name": "RLIM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281679", "map_id": "DDB_G0281679", "name": "RLIM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KP2", "map_id": "Q54KP2", "name": "TRIP12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287221", "map_id": "DDB_G0287221", "name": "TRIP12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GG5", "map_id": "Q54GG5", "name": "HECTD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290179", "map_id": "DDB_G0290179", "name": "HECTD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XF1", "map_id": "Q54XF1", "name": "RBBP6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279003", "map_id": "DDB_G0279003", "name": "RBBP6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q553F3", "map_id": "Q553F3", "name": "ubc2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275787", "map_id": "DDB_G0275787", "name": "ubc2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10596525", "map_id": "none", "name": "E3:Ub:substrate", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10596517", "map_id": "none", "name": "E2 Ubiquitin-conjugating enzyme", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10596448", "map_id": "none", "name": "E3 ligases in proteasomal degradation", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10596579", "map_id": "none", "name": "Release of E3 from polyubiquitinated substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10596577", "map_id": "none", "name": "E3:K48-polyubiquitinated substrate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_983123", "map_id": "none", "name": "K48polyUb-antigenic substrate", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10596610", "map_id": "none", "name": "Transfer of ubiquitin from E1 to E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10596607", "map_id": "none", "name": "E1 bound ubiquitin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10596605", "map_id": "none", "name": "Ubiquitin activating E1 enzymes", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10596519", "map_id": "none", "name": "Ubiquitin:E2 conjugating enzymes", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10596613", "map_id": "none", "name": "E1 mediated ubiquitin activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10596581", "map_id": "none", "name": "Proteasomal cleavage of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_983032", "map_id": "CHEBI:25676", "name": "oligopeptide fragment (8-16aa)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8942986", "map_id": "CHEBI:59869", "name": "L-amino acid", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_983036", "map_id": "CHEBI:25676", "name": "precursor peptide fragment (>16 aa)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10623191", "map_id": "none", "name": "THOP1 cleaves oligopeptide fragment (8-16aa)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8955634", "map_id": "CHEBI:25676", "name": "oligopeptide fragment (3-7aa)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10623188", "map_id": "Q54DD2", "name": "THOP1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0292362", "map_id": "DDB_G0292362", "name": "THOP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10596663", "map_id": "none", "name": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10596660", "map_id": "none", "name": "IFN gamma stimulated aminopeptidases", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q557I4", "map_id": "Q557I4", "name": "ERAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273419", "map_id": "DDB_G0273419", "name": "ERAP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CT4", "map_id": "Q55CT4", "name": "psaA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270994", "map_id": "DDB_G0270994", "name": "psaA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CY7", "map_id": "Q55CY7", "name": "psaB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270670", "map_id": "DDB_G0270670", "name": "psaB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10596616", "map_id": "none", "name": "Polyubiquitination of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10596618", "map_id": "none", "name": "Interaction of E3 with substrate and E2-Ub complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_983035", "map_id": "none", "name": "antigenic substrate", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10596569", "map_id": "none", "name": "Transport of Antigen peptide in to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_983034", "map_id": "CHEBI:25676", "name": "oligopeptide fragment", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10596566", "map_id": "none", "name": "TAP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54BU4", "map_id": "Q54BU4", "name": "abcB1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293416", "map_id": "DDB_G0293416", "name": "abcB1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T9W1", "map_id": "Q8T9W1", "name": "tagD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286123", "map_id": "DDB_G0286123", "name": "tagD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54683", "map_id": "P54683", "name": "tagB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286119", "map_id": "DDB_G0286119", "name": "tagB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23868", "map_id": "Q23868", "name": "tagC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286121", "map_id": "DDB_G0286121", "name": "tagC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10596648", "map_id": "none", "name": "Trimming of peptides in ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_8943716", "map_id": "CHEBI:59869", "name": "L-amino acid", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_983033", "map_id": "CHEBI:25676", "name": "Antigen peptide", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10596645", "map_id": "none", "name": "ERAP1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10588094", "map_id": "none", "name": "Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10587919", "map_id": "none", "name": "SAR1B:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q559R0", "map_id": "Q559R0", "name": "sarA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272296", "map_id": "DDB_G0272296", "name": "sarA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10588090", "map_id": "none", "name": "SEC23:SEC24", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54T59", "map_id": "Q54T59", "name": "sec23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281985", "map_id": "DDB_G0281985", "name": "sec23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54U61", "map_id": "Q54U61", "name": "sec24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281255", "map_id": "DDB_G0281255", "name": "sec24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Z72", "map_id": "Q54Z72", "name": "sec24l", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277797", "map_id": "DDB_G0277797", "name": "sec24l", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10588092", "map_id": "none", "name": "SAR1B:GTP:SEC23:SEC24", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10597282", "map_id": "none", "name": "Proteasomal clevage of exogenous antigen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1236719", "map_id": "CHEBI:16670", "name": "Exogenous soluble antigen", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10583537", "map_id": "none", "name": "PLC-beta hydrolyses PIP2 to DAG and IP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10583532", "map_id": "none", "name": "PLC-beta:G-alpha(q/11):PIP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10583534", "map_id": "none", "name": "PLC-beta:G-alpha(q/11):DAG:IP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10624320", "map_id": "none", "name": "G alpha (q):RGS dissociates to inactive G alpha (q)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10624315", "map_id": "none", "name": "G alpha (q):GDP:RGS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54LD1", "map_id": "Q54LD1", "name": "RGS16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286817", "map_id": "DDB_G0286817", "name": "RGS16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54M81", "map_id": "Q54M81", "name": "RGS16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q556I3", "map_id": "Q556I3", "name": "RGS16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55E55", "map_id": "Q55E55", "name": "RGS16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10590812", "map_id": "none", "name": "G-protein alpha (q/11):GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10624295", "map_id": "none", "name": "RGS1,2,3,4,5,13,16,17,18,19,21", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10590869", "map_id": "none", "name": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10582953", "map_id": "none", "name": "G protein alpha:GTP complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10590867", "map_id": "none", "name": "RGS proteins active for G alpha (q)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10624299", "map_id": "none", "name": "Active G alpha (q) binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10624297", "map_id": "none", "name": "G alpha (q):GTP:RGS", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10583555", "map_id": "none", "name": "Binding of IP3 to IP3 receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10583548", "map_id": "none", "name": "IP3R tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114521", "compartment_display": "platelet dense tubular network membrane", "complex": "true" }, { "id": "reaction_10591430", "map_id": "none", "name": "DAG is metabolized by DAGL to 2-AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_114519", "map_id": "CHEBI:17815", "name": "DAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_426026", "map_id": "CHEBI:35366", "name": "Fatty Acid", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_426030", "map_id": "CHEBI:52392", "name": "2AG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10591427", "map_id": "none", "name": "Diacylglycerol lipase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54ET1", "map_id": "Q54ET1", "name": "DAGLB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291354", "map_id": "DDB_G0291354", "name": "DAGLB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GX3", "map_id": "Q54GX3", "name": "DAGLB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YL1", "map_id": "Q54YL1", "name": "DAGLB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10591452", "map_id": "none", "name": "DAG kinase produces phosphatidic acid from DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_76108", "map_id": "CHEBI:29089", "name": "1,2-daG3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10591435", "map_id": "P34125", "name": "dgkA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0277223", "map_id": "DDB_G0277223", "name": "dgkA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10624318", "map_id": "none", "name": "G alpha (q) in G (q):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10580531", "map_id": "none", "name": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_83960", "map_id": "CHEBI:17821", "name": "Thy", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_73541", "map_id": "CHEBI:27468", "name": "5,6-Dihydrothymine", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10580469", "map_id": "none", "name": "DPYD dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55FT1", "map_id": "Q55FT1", "name": "pyd1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267966", "map_id": "DDB_G0267966", "name": "pyd1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10580482", "map_id": "none", "name": "5,6-dihydrouracil + H2O => beta-ureidopropionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_73584", "map_id": "CHEBI:15901", "name": "5,6-Dihydrouracil", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_73588", "map_id": "CHEBI:18261", "name": "UPROP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10580479", "map_id": "none", "name": "DPYS tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55DL0", "map_id": "Q55DL0", "name": "pyd2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269246", "map_id": "DDB_G0269246", "name": "pyd2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10580533", "map_id": "none", "name": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_73617", "map_id": "CHEBI:1670", "name": "UIBA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10580535", "map_id": "none", "name": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_73619", "map_id": "CHEBI:16320", "name": "3AIB", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_31633", "map_id": "CHEBI:28938", "name": "NH4+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10580489", "map_id": "none", "name": "UPB1:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q964D8", "map_id": "Q964D8", "name": "pyd3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274123", "map_id": "DDB_G0274123", "name": "pyd3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10581240", "map_id": "none", "name": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500430", "map_id": "none", "name": "(d)Ura", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:16450", "map_id": "CHEBI:16450", "name": "CHEBI:16450", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16704", "map_id": "CHEBI:16704", "name": "CHEBI:16704", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_83962", "map_id": "CHEBI:17568", "name": "Ura", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_500244", "map_id": "none", "name": "R1P, dRibP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:28542", "map_id": "CHEBI:28542", "name": "CHEBI:28542", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_112016", "map_id": "CHEBI:35425", "name": "R1P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10581235", "map_id": "none", "name": "UPP1, UPP2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54PM8", "map_id": "Q54PM8", "name": "udpA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284431", "map_id": "DDB_G0284431", "name": "udpA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10580472", "map_id": "none", "name": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10580492", "map_id": "none", "name": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_73590", "map_id": "CHEBI:16958", "name": "b-Ala", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10623846", "map_id": "none", "name": "MECR dimer reduces tdec2-CoA to DEC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77343", "map_id": "CHEBI:10723", "name": "tdec2-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77308", "map_id": "CHEBI:28493", "name": "DEC-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10623843", "map_id": "none", "name": "MECR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54YT4", "map_id": "Q54YT4", "name": "mecr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278095", "map_id": "DDB_G0278095", "name": "mecr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10582430", "map_id": "none", "name": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77341", "map_id": "CHEBI:28325", "name": "(S)-Hydroxydecanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10578064", "map_id": "none", "name": "ECHS1 hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q1ZXF1", "map_id": "Q1ZXF1", "name": "echs1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285071", "map_id": "DDB_G0285071", "name": "echs1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586368", "map_id": "none", "name": "Internalization of gap junction plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10586270", "map_id": "none", "name": "Homologues of MYO6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10586248", "map_id": "none", "name": "Planar gap junction plaques associated with Dab2 and Dynamin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10586366", "map_id": "none", "name": "Invaginating gap junction plaques", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10586370", "map_id": "none", "name": "Lysosomal degradation of gap junction plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10586762", "map_id": "none", "name": "Dynamin is recruited to the gap junction plaque", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10586246", "map_id": "none", "name": "Dynamin", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10586226", "map_id": "none", "name": "planar gap junction plaques associated with Dab2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10576483", "map_id": "none", "name": "Orc5 associates with Orc3:Orc2:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10576479", "map_id": "Q54C22", "name": "orcE", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0293214", "map_id": "DDB_G0293214", "name": "orcE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10576472", "map_id": "none", "name": "Orc3:Orc2:origin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55CU7", "map_id": "Q55CU7", "name": "orcB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269894", "map_id": "DDB_G0269894", "name": "orcB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BR6", "map_id": "Q55BR6", "name": "orcC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271078", "map_id": "DDB_G0271078", "name": "orcC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10576481", "map_id": "none", "name": "Orc5:Orc3:Orc2:origin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54C22", "map_id": "Q54C22", "name": "orcE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10576501", "map_id": "none", "name": "Orc1 associates with Orc4:Orc5:Orc3:Orc2:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10576490", "map_id": "none", "name": "Orc4:Orc5:Orc3:Orc2:origin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q86AD6", "map_id": "Q86AD6", "name": "orcD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271562", "map_id": "DDB_G0271562", "name": "orcD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10576497", "map_id": "Q54RM2", "name": "orcA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0283073", "map_id": "DDB_G0283073", "name": "phospho-orcA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10576499", "map_id": "none", "name": "Orc1:Orc4:Orc5:Orc3:Orc2:origin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54RM2", "map_id": "Q54RM2", "name": "phospho-orcA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10576474", "map_id": "none", "name": "Orc3 associates with Orc2 constitutively bound at origins of replication", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10576463", "map_id": "Q55BR6", "name": "orcC", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10576470", "map_id": "none", "name": "Orc2:origin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10576492", "map_id": "none", "name": "Orc4 associates with Orc5:Orc3:Orc2:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10576488", "map_id": "Q86AD6", "name": "orcD", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10576510", "map_id": "none", "name": "Orc6 associates with Orc1:Orc4:Orc5:Orc3:Orc2:origin complexes, forming ORC:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10576506", "map_id": "Q54P62", "name": "orcF", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0284771", "map_id": "DDB_G0284771", "name": "orcF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10576508", "map_id": "none", "name": "ORC complex bound to origin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54P62", "map_id": "Q54P62", "name": "orcF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10600374", "map_id": "none", "name": "Growing HA is extruded from the cell by ABCC5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_2142896", "map_id": "none", "name": "HA polymer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_2162224", "map_id": "CHEBI:64024", "name": "GlcA-\u03b21,3-GlcNAc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2160848", "map_id": "none", "name": "HA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10597751", "map_id": "none", "name": "Homologues of ABCC5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54V86", "map_id": "Q54V86", "name": "abcC13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280539", "map_id": "DDB_G0280539", "name": "abcC13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T6H3", "map_id": "Q8T6H3", "name": "abcC6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287593", "map_id": "DDB_G0287593", "name": "abcC6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54EK2", "map_id": "Q54EK2", "name": "abcC7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291243", "map_id": "DDB_G0291243", "name": "abcC7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T6H8", "map_id": "Q8T6H8", "name": "abcC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280541", "map_id": "DDB_G0280541", "name": "abcC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54K24", "map_id": "Q54K24", "name": "abcC14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287589", "map_id": "DDB_G0287589", "name": "abcC14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VC1", "map_id": "Q54VC1", "name": "abcC15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280459", "map_id": "DDB_G0280459", "name": "abcC15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VJ0", "map_id": "Q54VJ0", "name": "abcC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280055", "map_id": "DDB_G0280055", "name": "abcC2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NL1", "map_id": "Q54NL1", "name": "abcC9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285165", "map_id": "DDB_G0285165", "name": "abcC9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10611339", "map_id": "none", "name": "CEMIP hydrolyses HA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_5693343", "map_id": "CHEBI:64024", "name": "GlcA-b1,3-GlcNAc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10611336", "map_id": "none", "name": "Homologues of CEMIP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q54KF6", "map_id": "Q54KF6", "name": "CEMIP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287365", "map_id": "DDB_G0287365", "name": "CEMIP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55D62", "map_id": "Q55D62", "name": "CEMIP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10616531", "map_id": "none", "name": "PLK3 phosphorylates CDC25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10581492", "map_id": "Q54QM6", "name": "cdc25", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0283617", "map_id": "DDB_G0283617", "name": "phospho-cdc25", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10616519", "map_id": "Q54QM6", "name": "phospho-cdc25", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10616528", "map_id": "none", "name": "Homologues of PLK3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54BR8", "map_id": "Q54BR8", "name": "cbfB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293470", "map_id": "DDB_G0293470", "name": "cbfB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10613702", "map_id": "none", "name": "BTG2 binds CCR4-NOT complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10613698", "map_id": "none", "name": "CCR4-NOT Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q554L0", "map_id": "Q554L0", "name": "CNOT4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275005", "map_id": "DDB_G0275005", "name": "CNOT4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55D59", "map_id": "Q55D59", "name": "RQCD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269778", "map_id": "DDB_G0269778", "name": "RQCD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HH3", "map_id": "Q54HH3", "name": "CNOT6L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289461", "map_id": "DDB_G0289461", "name": "CNOT6L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PZ4", "map_id": "Q54PZ4", "name": "CNOT8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285269", "map_id": "DDB_G0285269", "name": "CNOT8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NG7", "map_id": "Q54NG7", "name": "CNOT8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXI2", "map_id": "Q1ZXI2", "name": "cnot11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279005", "map_id": "DDB_G0279005", "name": "cnot11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q75JL4", "map_id": "Q75JL4", "name": "DG1040", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276029", "map_id": "DDB_G0276029", "name": "DG1040", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54U17", "map_id": "Q54U17", "name": "CNOT10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281363", "map_id": "DDB_G0281363", "name": "CNOT10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PG2", "map_id": "Q54PG2", "name": "CNOT2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284577", "map_id": "DDB_G0284577", "name": "CNOT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AA8", "map_id": "Q55AA8", "name": "CNOT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272056", "map_id": "DDB_G0272056", "name": "CNOT3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10613634", "map_id": "Q54NU5", "name": "btg", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0285069", "map_id": "DDB_G0285069", "name": "btg", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10613700", "map_id": "none", "name": "BTG2:CCR4-NOT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54NU5", "map_id": "Q54NU5", "name": "btg", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10616032", "map_id": "none", "name": "TP53I3 oxidoreductase generates unstable semiquinones", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6799725", "map_id": "CHEBI:34055", "name": "1,2-Naphthoquinone", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6799726", "map_id": "CHEBI:15817", "name": "semiquinone", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10615972", "map_id": "none", "name": "TP53I3 Dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q75JT6", "map_id": "Q75JT6", "name": "TP53I3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272440", "map_id": "DDB_G0272440", "name": "TP53I3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10616466", "map_id": "none", "name": "RABGGTA binds RABGGTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10616462", "map_id": "B0G172", "name": "rabggtb", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0290671", "map_id": "DDB_G0290671", "name": "rabggtb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10616457", "map_id": "Q55DQ4", "name": "rabggta", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0269570", "map_id": "DDB_G0269570", "name": "rabggta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10616464", "map_id": "none", "name": "RGGT", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q55DQ4", "map_id": "Q55DQ4", "name": "rabggta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B0G172", "map_id": "B0G172", "name": "rabggtb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10615974", "map_id": "none", "name": "TP53I3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10615970", "map_id": "Q75JT6", "name": "TP53I3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10616475", "map_id": "none", "name": "CHM binds RGGT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10616471", "map_id": "Q54VT9", "name": "CHM", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0280143", "map_id": "DDB_G0280143", "name": "CHML", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10616473", "map_id": "none", "name": "RGGT:CHM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54VT9", "map_id": "Q54VT9", "name": "CHML", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10616445", "map_id": "none", "name": "PIDD1 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10616441", "map_id": "Q54PM1", "name": "phospho-p-T788-PIDD1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10616443", "map_id": "Q54PM1", "name": "phospho-p-T788-PIDD1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10616491", "map_id": "none", "name": "TRIAP1 binds PRELID1, PRELID3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space" }, { "id": "species_10616485", "map_id": "Q54G07", "name": "slmo", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "DDB_G0290499", "map_id": "DDB_G0290499", "name": "slmo", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10616480", "map_id": "Q54KL1", "name": "TRIAP1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "DDB_G0287279", "map_id": "DDB_G0287279", "name": "TRIAP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10616489", "map_id": "none", "name": "TRIAP1:PRELID1, PRELID3A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "Q54KL1", "map_id": "Q54KL1", "name": "TRIAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54G07", "map_id": "Q54G07", "name": "slmo", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10616494", "map_id": "none", "name": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "reaction_10613581", "map_id": "none", "name": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10613565", "map_id": "none", "name": "CCNK:CDK12:Elongation Complex at DNA Repair Genes", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54LJ0", "map_id": "Q54LJ0", "name": "CCNT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286617", "map_id": "DDB_G0286617", "name": "CCNT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q75JA4", "map_id": "Q75JA4", "name": "CTDP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271690", "map_id": "DDB_G0271690", "name": "CTDP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55F13", "map_id": "Q55F13", "name": "NELFCD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268678", "map_id": "DDB_G0268678", "name": "NELFCD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Q08", "map_id": "Q54Q08", "name": "NELFB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284195", "map_id": "DDB_G0284195", "name": "NELFB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q556Z2", "map_id": "Q556Z2", "name": "CDK9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273207", "map_id": "DDB_G0273207", "name": "CDK9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NF2", "map_id": "Q54NF2", "name": "spt4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285293", "map_id": "DDB_G0285293", "name": "spt4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CM9", "map_id": "Q55CM9", "name": "TCEB3B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269992", "map_id": "DDB_G0269992", "name": "TCEB3B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XU3", "map_id": "Q54XU3", "name": "TCEA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278963", "map_id": "DDB_G0278963", "name": "TCEA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YG9", "map_id": "Q54YG9", "name": "tcea1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278241", "map_id": "DDB_G0278241", "name": "tcea1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10613578", "map_id": "none", "name": "CCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genes", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10613541", "map_id": "none", "name": "TORC2 complex phosphorylates SGK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10613531", "map_id": "none", "name": "Homologues of SGK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10613539", "map_id": "none", "name": "Homologues of p-S422-SGK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10613551", "map_id": "none", "name": "PDPK1 phosphorylates SGK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10613549", "map_id": "none", "name": "Homologues of p-T256,S422-SGK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10577717", "map_id": "none", "name": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_31467", "map_id": "CHEBI:16938", "name": "D-Glucono-1,5-lactone 6-phosphate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10577714", "map_id": "none", "name": "G6PD dimer and tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q557D2", "map_id": "Q557D2", "name": "g6pd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273131", "map_id": "DDB_G0273131", "name": "g6pd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10605925", "map_id": "none", "name": "PRDX1 overoxidizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605917", "map_id": "none", "name": "PRDX1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q555L5", "map_id": "Q555L5", "name": "prdx4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274859", "map_id": "DDB_G0274859", "name": "prdx4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10605922", "map_id": "none", "name": "HOOS-C52-PRDX1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10605942", "map_id": "none", "name": "SESN1,2,3 bind overoxidized PRDX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605938", "map_id": "none", "name": "SESN1,2,3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54WU6", "map_id": "Q54WU6", "name": "SESN2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279427", "map_id": "DDB_G0279427", "name": "SESN2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10605940", "map_id": "none", "name": "SESN1,2,3:HOOS-C52-PRDX1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10578681", "map_id": "none", "name": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111745", "map_id": "CHEBI:17858", "name": "GSSG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29450", "map_id": "CHEBI:16856", "name": "GSH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10578678", "map_id": "none", "name": "GSR-2:FAD dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8T137", "map_id": "Q8T137", "name": "gsr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272754", "map_id": "DDB_G0272754", "name": "gsr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10589979", "map_id": "none", "name": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10586987", "map_id": "none", "name": "AKT phosphorylates TSC2, inhibiting it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10584141", "map_id": "Q54VB2", "name": "TSC2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0280527", "map_id": "DDB_G0280527", "name": "phospho-p-S939,T1462-TSC2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10586984", "map_id": "Q54VB2", "name": "phospho-p-S939,T1462-TSC2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10605946", "map_id": "none", "name": "SESN1,2,3 bind AMPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605944", "map_id": "none", "name": "SESN1,2,3:p-AMPK heterotrimer:AMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10624930", "map_id": "none", "name": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_1614595", "map_id": "CHEBI:16094", "name": "S2O3(2-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_9013199", "map_id": "CHEBI:18407", "name": "HCN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_9013207", "map_id": "CHEBI:17359", "name": "SO3(2-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_9013191", "map_id": "CHEBI:29200", "name": "HSCN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10624637", "map_id": "Q54E40", "name": "MPST", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0291816", "map_id": "DDB_G0291816", "name": "CysS248-MPST", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617891", "map_id": "none", "name": "ADO oxidises 2AET to HTAU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6814151", "map_id": "CHEBI:17141", "name": "2AET", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1655445", "map_id": "CHEBI:16668", "name": "HTAU", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10617888", "map_id": "none", "name": "ADO:Fe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q556I2", "map_id": "Q556I2", "name": "ado-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273031", "map_id": "DDB_G0273031", "name": "ado-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10624640", "map_id": "none", "name": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_9012724", "map_id": "CHEBI:17137", "name": "HSO3-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_9012592", "map_id": "CHEBI:16208", "name": "3MPYR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113557", "map_id": "CHEBI:15361", "name": "PYR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10598498", "map_id": "none", "name": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111707", "map_id": "CHEBI:35235", "name": "L-Cys", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1614519", "map_id": "CHEBI:16345", "name": "3-Sulfinoalanine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10598495", "map_id": "none", "name": "CDO1:Fe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54K68", "map_id": "Q54K68", "name": "CDO1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287555", "map_id": "DDB_G0287555", "name": "CDO1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10624934", "map_id": "none", "name": "MPST transfers sulfur from sulfanegen to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_9013543", "map_id": "none", "name": "sulfanegen", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10624932", "map_id": "none", "name": "MPST transfers sulfur from 3MPYR to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10598477", "map_id": "none", "name": "Excess homocysteine yields homolanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_174369", "map_id": "CHEBI:17230", "name": "HCYS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1614532", "map_id": "CHEBI:16136", "name": "H2S", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1614594", "map_id": "CHEBI:62856", "name": "HLAN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10598474", "map_id": "none", "name": "PXLP-K212-CTH tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55DV9", "map_id": "Q55DV9", "name": "cysA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269122", "map_id": "DDB_G0269122", "name": "cysA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625805", "map_id": "none", "name": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10625803", "map_id": "Q54E40", "name": "CysS248-MPST", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10625811", "map_id": "none", "name": "CysS248-MPST:TXN2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10625807", "map_id": "none", "name": "CysS248-MPST:TXN2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54NX3", "map_id": "Q54NX3", "name": "2xHC-TXN2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284939", "map_id": "DDB_G0284939", "name": "2xHC-TXN2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54E40", "map_id": "Q54E40", "name": "CysS248-MPST", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10602636", "map_id": "Q54NX3", "name": "2xHC-TXN2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_1655881", "map_id": "CHEBI:16136", "name": "H2S", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10598483", "map_id": "none", "name": "Excess cysteine yields lanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1614582", "map_id": "CHEBI:21347", "name": "L-Lanthionine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10625809", "map_id": "none", "name": "TXN2 binds CysS248-MPST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10602633", "map_id": "Q54NX3", "name": "TXN2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10598485", "map_id": "none", "name": "Cysteine is degraded to serine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10598488", "map_id": "none", "name": "Homocysteine is degraded to oxobutanoate and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10598464", "map_id": "none", "name": "Sulfite is oxidized to sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113533", "map_id": "CHEBI:15379", "name": "O2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_1614538", "map_id": "CHEBI:17359", "name": "sulfite(2-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_1614617", "map_id": "CHEBI:16240", "name": "H2O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_1614584", "map_id": "CHEBI:16189", "name": "SO4(2-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10598461", "map_id": "none", "name": "holo-SUOX", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54XJ8", "map_id": "Q54XJ8", "name": "SUOX", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278893", "map_id": "DDB_G0278893", "name": "SUOX", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_947539", "map_id": "CHEBI:25372", "name": "MoCo", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10598466", "map_id": "none", "name": "Sulfate is exported to the cytosol in exchange for dicarboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_174375", "map_id": "CHEBI:16189", "name": "SO4(2-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10599916", "map_id": "none", "name": "Phosphorylated MOB1A proteins associate with LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10599890", "map_id": "none", "name": "p-MOB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54BM4", "map_id": "Q54BM4", "name": "phospho-mobC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293706", "map_id": "DDB_G0293706", "name": "phospho-mobC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CR8", "map_id": "Q54CR8", "name": "phospho-mobB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292758", "map_id": "DDB_G0292758", "name": "phospho-mobB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XJ0", "map_id": "Q54XJ0", "name": "phospho-mobA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278907", "map_id": "DDB_G0278907", "name": "phospho-mobA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QV0", "map_id": "Q54QV0", "name": "phospho-mob2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283625", "map_id": "DDB_G0283625", "name": "phospho-mob2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10599858", "map_id": "none", "name": "LATS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q1ZXI5", "map_id": "Q1ZXI5", "name": "LATS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278845", "map_id": "DDB_G0278845", "name": "LATS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HD2", "map_id": "Q54HD2", "name": "ndrD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289543", "map_id": "DDB_G0289543", "name": "ndrD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54P47", "map_id": "Q54P47", "name": "ndrC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284839", "map_id": "DDB_G0284839", "name": "ndrC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10599892", "map_id": "none", "name": "LATS:p-MOB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10624545", "map_id": "none", "name": "GSTZ1 dimer dehalogenates DCA to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_9010792", "map_id": "none", "name": "DCA", "type": "inhibitor", "sub_type": "other", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_904849", "map_id": "CHEBI:16891", "name": "glyoxylate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_3301973", "map_id": "CHEBI:17883", "name": "HCl", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10624542", "map_id": "none", "name": "GSTZ1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54YN2", "map_id": "Q54YN2", "name": "mai", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278155", "map_id": "DDB_G0278155", "name": "mai", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_1655887", "map_id": "CHEBI:16856", "name": "GSH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10583891", "map_id": "none", "name": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_162860", "map_id": "CHEBI:15820", "name": "GDP-Man", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_449299", "map_id": "CHEBI:16214", "name": "DOLP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_162681", "map_id": "CHEBI:15809", "name": "DOLP-Man", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10583888", "map_id": "none", "name": "DPM1:DPM2:DPM3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54LP3", "map_id": "Q54LP3", "name": "dpm1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286519", "map_id": "DDB_G0286519", "name": "dpm1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q556K9", "map_id": "Q556K9", "name": "dpm2-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272588", "map_id": "DDB_G0272588", "name": "dpm2-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q76NT6", "map_id": "Q76NT6", "name": "dpm3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277435", "map_id": "DDB_G0277435", "name": "dpm3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10611745", "map_id": "none", "name": "COPII coat binds TRAPPCII and RAB1:GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13959", "compartment_display": "COPII-coated ER to Golgi transport vesicle" }, { "id": "species_10588070", "map_id": "none", "name": "COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13945", "compartment_display": "ER to Golgi transport vesicle membrane", "complex": "true" }, { "id": "Q559Q3", "map_id": "Q559Q3", "name": "(Glc)3(GlcNAc)2(Man)9-CTSC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272298", "map_id": "DDB_G0272298", "name": "(Glc)3(GlcNAc)2(Man)9-CTSC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54J84", "map_id": "Q54J84", "name": "(Glc)3(GlcNAc)2(Man)9-CTSZ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288221", "map_id": "DDB_G0288221", "name": "(Glc)3(GlcNAc)2(Man)9-CTSZ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ME1", "map_id": "Q54ME1", "name": "gmsA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286015", "map_id": "DDB_G0286015", "name": "gmsA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54R55", "map_id": "Q54R55", "name": "(Glc)3(GlcNAc)2(Man)9-CTSZ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VR1", "map_id": "Q54VR1", "name": "(Glc)3(GlcNAc)2(Man)9-CTSZ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T2J5", "map_id": "Q8T2J5", "name": "LMAN2L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271968", "map_id": "DDB_G0271968", "name": "LMAN2L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FD0", "map_id": "Q55FD0", "name": "GOSR2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268452", "map_id": "DDB_G0268452", "name": "GOSR2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ZH1", "map_id": "Q54ZH1", "name": "syn5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277565", "map_id": "DDB_G0277565", "name": "syn5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CT5", "map_id": "Q55CT5", "name": "sec31", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270992", "map_id": "DDB_G0270992", "name": "sec31", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DS8", "map_id": "Q54DS8", "name": "sec13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292052", "map_id": "DDB_G0292052", "name": "sec13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10611620", "map_id": "none", "name": "TRAPPCII", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54UU1", "map_id": "Q54UU1", "name": "trappc4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280827", "map_id": "DDB_G0280827", "name": "trappc4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TK7", "map_id": "Q54TK7", "name": "TRAPPC6A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281693", "map_id": "DDB_G0281693", "name": "TRAPPC6A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RV6", "map_id": "Q54RV6", "name": "trappc2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282887", "map_id": "DDB_G0282887", "name": "trappc2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CU7", "map_id": "Q54CU7", "name": "trappc2l", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292690", "map_id": "DDB_G0292690", "name": "trappc2l", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YG5", "map_id": "Q54YG5", "name": "trappc5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278643", "map_id": "DDB_G0278643", "name": "trappc5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q557G3", "map_id": "Q557G3", "name": "trappc1-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273467", "map_id": "DDB_G0273467", "name": "trappc1-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q555X3", "map_id": "Q555X3", "name": "TRAPPC9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274803", "map_id": "DDB_G0274803", "name": "TRAPPC9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q556Z3", "map_id": "Q556Z3", "name": "trapcc10-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273209", "map_id": "DDB_G0273209", "name": "trapcc10-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86K94", "map_id": "Q86K94", "name": "trappc3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277135", "map_id": "DDB_G0277135", "name": "trappc3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10611622", "map_id": "none", "name": "COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13959", "compartment_display": "COPII-coated ER to Golgi transport vesicle", "complex": "true" }, { "id": "reaction_10588096", "map_id": "none", "name": "SEC31:SEC13 and v-SNARE recruitment", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10587867", "map_id": "none", "name": "SEC31A:SEC13:SEC23IP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10587880", "map_id": "none", "name": "ER-to-ERGIC v-SNARES", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10588000", "map_id": "none", "name": "COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q55BR0", "map_id": "Q55BR0", "name": "wimA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269198", "map_id": "DDB_G0269198", "name": "wimA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10588002", "map_id": "none", "name": "COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10588082", "map_id": "none", "name": "SAR1 Activation And Membrane Binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10588074", "map_id": "none", "name": "SAR1B:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10588079", "map_id": "Q54M76", "name": "PREB", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0286167", "map_id": "DDB_G0286167", "name": "PREB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10611842", "map_id": "none", "name": "Loss of SAR1B GTPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10587994", "map_id": "none", "name": "COPII cargo receptors:SAR1B:GTP:SEC23:SEC24", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10587992", "map_id": "none", "name": "COPII cargo:receptors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10618326", "map_id": "none", "name": "TBC1D20 binds RAB1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10611792", "map_id": "none", "name": "RAB1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "species_10618322", "map_id": "Q54RT5", "name": "TBC1D20", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "false" }, { "id": "DDB_G0283055", "map_id": "DDB_G0283055", "name": "TBC1D20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10618324", "map_id": "none", "name": "RAB1:GTP:TBC1D20", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "Q54RT5", "map_id": "Q54RT5", "name": "TBC1D20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10611687", "map_id": "none", "name": "PP6 dephosphorylates SEC24", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10611666", "map_id": "none", "name": "p-SEC24", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10588088", "map_id": "none", "name": "SEC24", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10611684", "map_id": "none", "name": "PP6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55FM2", "map_id": "Q55FM2", "name": "PPP6R1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268044", "map_id": "DDB_G0268044", "name": "PPP6R1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U9A3", "map_id": "Q9U9A3", "name": "ppp6c", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272118", "map_id": "DDB_G0272118", "name": "ppp6c", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10611800", "map_id": "none", "name": "CSNK1D phosphorylates SEC23", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10611760", "map_id": "none", "name": "COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "Q54C46", "map_id": "Q54C46", "name": "GORASP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293248", "map_id": "DDB_G0293248", "name": "GORASP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q553R1", "map_id": "Q553R1", "name": "USO1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275331", "map_id": "DDB_G0275331", "name": "USO1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10611766", "map_id": "none", "name": "COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "species_10611764", "map_id": "Q54T59", "name": "phospho-sec23", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10611797", "map_id": "Q556Y4", "name": "cak1-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "false" }, { "id": "reaction_10611738", "map_id": "none", "name": "NSF and SNAPs bind cis-SNARE complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10611734", "map_id": "none", "name": "cis-SNARE", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "Q54IJ1", "map_id": "Q54IJ1", "name": "scfd1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288719", "map_id": "DDB_G0288719", "name": "scfd1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SJ2", "map_id": "Q54SJ2", "name": "BET1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282433", "map_id": "DDB_G0282433", "name": "BET1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10611736", "map_id": "none", "name": "cis-SNARE:NSF hexamer:3xSNAP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "reaction_10618329", "map_id": "none", "name": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "reaction_10611629", "map_id": "none", "name": "Nucleotide exchange on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13959", "compartment_display": "COPII-coated ER to Golgi transport vesicle" }, { "id": "species_10611626", "map_id": "none", "name": "COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13959", "compartment_display": "COPII-coated ER to Golgi transport vesicle", "complex": "true" }, { "id": "reaction_10611741", "map_id": "none", "name": "NSF ATPase activity dissociates cis-SNARE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10611710", "map_id": "Q55FD0", "name": "GOSR2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "false" }, { "id": "species_10611724", "map_id": "none", "name": "STX5,17", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "species_10611708", "map_id": "Q54SJ2", "name": "BET1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "false" }, { "id": "species_10611732", "map_id": "none", "name": "ER-to-ERGIC v-SNARES", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "species_10611715", "map_id": "Q54IJ1", "name": "scfd1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10611839", "map_id": "none", "name": "Inner coat assembly and cargo binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10617088", "map_id": "none", "name": "ERGIC-to-Golgi vesicles bind dynein:dynactin ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_432051", "compartment_display": "transport vesicle" }, { "id": "species_10617084", "map_id": "none", "name": "RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_432051", "compartment_display": "transport vesicle", "complex": "true" }, { "id": "Q54BK5", "map_id": "Q54BK5", "name": "PalmC-YKT6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293712", "map_id": "DDB_G0293712", "name": "PalmC-YKT6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q550R2", "map_id": "Q550R2", "name": "ctxB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276893", "map_id": "DDB_G0276893", "name": "ctxB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10617086", "map_id": "none", "name": "RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_432051", "compartment_display": "transport vesicle", "complex": "true" }, { "id": "reaction_10617281", "map_id": "none", "name": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10617276", "map_id": "none", "name": "cis-SNARE:3xSNAP:NSF hexamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q54QH2", "map_id": "Q54QH2", "name": "GOSR1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283831", "map_id": "DDB_G0283831", "name": "GOSR1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10617262", "map_id": "Q55FD0", "name": "GOSR2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10617256", "map_id": "Q54SJ2", "name": "BET1L", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10617258", "map_id": "Q54ZH1", "name": "syn5", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10617237", "map_id": "Q54SJ2", "name": "BET1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10617143", "map_id": "Q54BK5", "name": "PalmC-YKT6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10617254", "map_id": "Q54QH2", "name": "GOSR1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10616792", "map_id": "none", "name": "GBF1 stimulates ARF nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10616785", "map_id": "none", "name": "RAB1:GTP:GBF1:USO1:ARF:GDP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "species_10616789", "map_id": "none", "name": "RAB1:GTP:GBF1:USO1:ARF:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "reaction_10616779", "map_id": "none", "name": "RAB1:GTP recruits GBF1 to the ERGIC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10616775", "map_id": "none", "name": "USO1 homodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10616777", "map_id": "none", "name": "RAB1:GTP:GBF1:USO1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "reaction_10617272", "map_id": "none", "name": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10617268", "map_id": "none", "name": "cis-Golgi t-SNARES", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10617249", "map_id": "none", "name": "RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q54YV5", "map_id": "Q54YV5", "name": "TMEM115", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278061", "map_id": "DDB_G0278061", "name": "TMEM115", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LC8", "map_id": "Q54LC8", "name": "cog7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286705", "map_id": "DDB_G0286705", "name": "cog7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54C87", "map_id": "Q54C87", "name": "COG4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293106", "map_id": "DDB_G0293106", "name": "COG4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ZB3", "map_id": "Q54ZB3", "name": "cog1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277691", "map_id": "DDB_G0277691", "name": "cog1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54UC2", "map_id": "Q54UC2", "name": "cog2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281163", "map_id": "DDB_G0281163", "name": "cog2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BB8", "map_id": "Q55BB8", "name": "cog8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271388", "map_id": "DDB_G0271388", "name": "cog8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HE0", "map_id": "Q54HE0", "name": "cog5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289535", "map_id": "DDB_G0289535", "name": "cog5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CT0", "map_id": "Q54CT0", "name": "cog6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292784", "map_id": "DDB_G0292784", "name": "cog6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TT4", "map_id": "Q54TT4", "name": "cog3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281511", "map_id": "DDB_G0281511", "name": "cog3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10617270", "map_id": "none", "name": "RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10617278", "map_id": "none", "name": "cis-Golgi cis-SNARE binds NSF and SNAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10617274", "map_id": "none", "name": "cis-Golgi cis SNARE bundle", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10616847", "map_id": "none", "name": "Active ARF recruits coatomer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10616845", "map_id": "none", "name": "RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "reaction_10611650", "map_id": "none", "name": "SEC4C,D bind GOSR2 and STX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10587933", "map_id": "Q54Z72", "name": "sec24l", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10587931", "map_id": "none", "name": "GOSR2,STX5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10587937", "map_id": "Q54T59", "name": "sec23", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10587939", "map_id": "none", "name": "SEC23A:SEC24C,D:GOSR2,STX5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10611654", "map_id": "none", "name": "SEC24A,B:SEC23A bind SEC22B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10588084", "map_id": "Q54U61", "name": "sec24", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10611652", "map_id": "none", "name": "SEC24A,B:SEC23A:SEC22B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10611743", "map_id": "none", "name": "LMAN family proteins bind glycosylated cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10587988", "map_id": "none", "name": "glycosylated LMAN cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10587954", "map_id": "none", "name": "LMAN family receptors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10587990", "map_id": "none", "name": "LMAN receptor:glycosylated cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10626054", "map_id": "none", "name": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10626042", "map_id": "none", "name": "Homologues of DAPP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54CE1", "map_id": "Q54CE1", "name": "phospho-p-Y139-DAPP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293166", "map_id": "DDB_G0293166", "name": "phospho-p-Y139-DAPP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54U56", "map_id": "Q54U56", "name": "phospho-p-Y139-DAPP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10626052", "map_id": "none", "name": "p-Y139-DAPP1:PIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10597136", "map_id": "none", "name": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10585874", "map_id": "none", "name": "p21 RAS:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10597133", "map_id": "none", "name": "p-RASGRP1,3:DAG", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10627377", "map_id": "none", "name": "FKBP1A binds tacrolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10584268", "map_id": "Q54UR2", "name": "FKBP1A", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0280877", "map_id": "DDB_G0280877", "name": "FKBP1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_9678991", "map_id": "none", "name": "tacrolimus", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10627375", "map_id": "none", "name": "FKBP1A:tacrolimus", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54UR2", "map_id": "Q54UR2", "name": "FKBP1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622977", "map_id": "none", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10622972", "map_id": "none", "name": "RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1 gene:H3K4me2-Nucleosome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54HI0", "map_id": "Q54HI0", "name": "prmt2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289445", "map_id": "DDB_G0289445", "name": "prmt2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54UJ3", "map_id": "Q54UJ3", "name": "SIN3A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281045", "map_id": "DDB_G0281045", "name": "SIN3A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10622974", "map_id": "none", "name": "RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1B gene:H3K4me2,H3R2me2a-Nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10622950", "map_id": "none", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10622945", "map_id": "none", "name": "RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2-Nucleosome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10622947", "map_id": "none", "name": "RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2,H3R2me2a-Nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10622986", "map_id": "none", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10622981", "map_id": "none", "name": "RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2-Nucleosome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10622983", "map_id": "none", "name": "RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2,H3R2me2a-Nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10622941", "map_id": "none", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10622927", "map_id": "none", "name": "RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2-Nucleosome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10622938", "map_id": "none", "name": "RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2,H3R2me2a-Nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10583367", "map_id": "none", "name": "Release of Cytochrome c from mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10583365", "map_id": "Q869N1", "name": "cytC", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10583363", "map_id": "Q869N1", "name": "cytC", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10582546", "map_id": "none", "name": "Recognition and Binding of Core Promoter Elements by TFIID", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10580910", "map_id": "none", "name": "TFIID", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54DH8", "map_id": "Q54DH8", "name": "taf1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292242", "map_id": "DDB_G0292242", "name": "taf1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q555L9", "map_id": "Q555L9", "name": "TAF12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274697", "map_id": "DDB_G0274697", "name": "TAF12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XM9", "map_id": "Q54XM9", "name": "taf11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278843", "map_id": "DDB_G0278843", "name": "taf11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BH6", "map_id": "Q55BH6", "name": "TAF7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271338", "map_id": "DDB_G0271338", "name": "TAF7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IW7", "map_id": "Q54IW7", "name": "TAF6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288471", "map_id": "DDB_G0288471", "name": "TAF6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KH7", "map_id": "Q54KH7", "name": "TAF5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287337", "map_id": "DDB_G0287337", "name": "TAF5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55A39", "map_id": "Q55A39", "name": "TAF9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272360", "map_id": "DDB_G0272360", "name": "TAF9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54X70", "map_id": "Q54X70", "name": "TAF4B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279179", "map_id": "DDB_G0279179", "name": "TAF4B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C7G081", "map_id": "C7G081", "name": "taf2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292724", "map_id": "DDB_G0292724", "name": "taf2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CN8", "map_id": "Q54CN8", "name": "taf13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292838", "map_id": "DDB_G0292838", "name": "taf13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P26355", "map_id": "P26355", "name": "tbpA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275617", "map_id": "DDB_G0275617", "name": "tbpA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_109627", "map_id": "none", "name": "DNA containing RNA Polymerase II promoter", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10581548", "map_id": "none", "name": "pol II promoter:TFIID complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10582548", "map_id": "none", "name": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10580844", "map_id": "Q54FD6", "name": "gtf2b", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0290929", "map_id": "DDB_G0290929", "name": "gtf2b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10580839", "map_id": "none", "name": "TFIIA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54G80", "map_id": "Q54G80", "name": "gtf2a1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290327", "map_id": "DDB_G0290327", "name": "gtf2a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ND1", "map_id": "Q54ND1", "name": "gtf2a2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285343", "map_id": "DDB_G0285343", "name": "gtf2a2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10581550", "map_id": "none", "name": "pol II promoter:TFIID:TFIIA:TFIIB complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54FD6", "map_id": "Q54FD6", "name": "gtf2b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10581556", "map_id": "none", "name": "Binding of TFIIE to the growing preinitiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10580922", "map_id": "none", "name": "TFIIE", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q557M8", "map_id": "Q557M8", "name": "gtf2e1-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273525", "map_id": "DDB_G0273525", "name": "gtf2e1-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KJ8", "map_id": "Q54KJ8", "name": "gtf2e2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287307", "map_id": "DDB_G0287307", "name": "gtf2e2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10581552", "map_id": "none", "name": "pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10581554", "map_id": "none", "name": "pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF:TFIIE complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10582550", "map_id": "none", "name": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10578889", "map_id": "none", "name": "RNA Polymerase II (unphosphorylated):TFIIF complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10582552", "map_id": "none", "name": "Formation of the closed pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10580699", "map_id": "none", "name": "TFIIH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10581638", "map_id": "none", "name": "pol II closed pre-initiation complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10582721", "map_id": "none", "name": "Cleavage of dihydrouracil by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10582718", "map_id": "none", "name": "NTHL1:DHU-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q86K43", "map_id": "Q86K43", "name": "NTH1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277247", "map_id": "DDB_G0277247", "name": "NTH1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_30140", "map_id": "CHEBI:15901", "name": "DHU", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10582704", "map_id": "none", "name": "NTHL1:AP-dsDNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10582691", "map_id": "none", "name": "Cleavage of uracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10582684", "map_id": "none", "name": "UNG-1:(Ura:Gua)-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P53766", "map_id": "P53766", "name": "uglA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277877", "map_id": "DDB_G0277877", "name": "uglA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29554", "map_id": "CHEBI:17568", "name": "Ura", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10582688", "map_id": "none", "name": "UNG-1:AP-dsDNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10582707", "map_id": "none", "name": "Cleavage of thymine glycol by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10582702", "map_id": "none", "name": "NTHL1:Tg-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_110223", "map_id": "CHEBI:29128", "name": "Tg", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10582728", "map_id": "none", "name": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10582725", "map_id": "none", "name": "NTHL1:FapyA-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_5637659", "map_id": "CHEBI:27983", "name": "FapyA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10582747", "map_id": "none", "name": "Excision of FapyG by OGG1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10582744", "map_id": "none", "name": "OGG1:FapyG-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54CZ3", "map_id": "Q54CZ3", "name": "OGG1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292618", "map_id": "DDB_G0292618", "name": "OGG1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5636006", "map_id": "CHEBI:29145", "name": "FapyG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10582739", "map_id": "none", "name": "OGG1:AP-dsDNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10582698", "map_id": "none", "name": "Cleavage of 5-hydroxyluracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10582695", "map_id": "none", "name": "UNG-1:5-OHU-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_110216", "map_id": "CHEBI:29115", "name": "5-OHU", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10582714", "map_id": "none", "name": "Cleavage of cytosine glycol by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10582711", "map_id": "none", "name": "NTHL1:Cg-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_110225", "map_id": "CHEBI:29127", "name": "Cg", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10604323", "map_id": "none", "name": "Secretion of SOD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10604321", "map_id": "none", "name": "SOD3 tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_437295", "map_id": "CHEBI:29036", "name": "Cu2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10602381", "map_id": "none", "name": "SOD3 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10602402", "map_id": "none", "name": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602399", "map_id": "none", "name": "2xHC-SOD1:Zn2+:Cu2+ dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10602373", "map_id": "none", "name": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_3299683", "map_id": "CHEBI:18421", "name": "O2.-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10602370", "map_id": "none", "name": "SOD2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q55BJ9", "map_id": "Q55BJ9", "name": "sod2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271106", "map_id": "DDB_G0271106", "name": "sod2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10602664", "map_id": "none", "name": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_1655882", "map_id": "CHEBI:17858", "name": "GSSG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10602661", "map_id": "none", "name": "GSR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10602668", "map_id": "none", "name": "Superoxide reduces cytochrome c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_3341308", "map_id": "CHEBI:18421", "name": "O2-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_189461", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "reaction_10602384", "map_id": "none", "name": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_351626", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_351629", "map_id": "CHEBI:16240", "name": "H2O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10602421", "map_id": "none", "name": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602414", "map_id": "none", "name": "CCS:Zn2+:2xCu1+:SOD1:Zn2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:49552", "map_id": "CHEBI:49552", "name": "CHEBI:49552", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54F73", "map_id": "Q54F73", "name": "ccs", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291031", "map_id": "DDB_G0291031", "name": "ccs", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10602418", "map_id": "none", "name": "CCS:Zn2+:Cu1+ dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10603063", "map_id": "none", "name": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602412", "map_id": "none", "name": "SOD1:Zn2+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10603059", "map_id": "none", "name": "CCS:Zn2+:2xCu1+ dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10603061", "map_id": "none", "name": "2xSOD1:CCS:Zn2+:2xCu1+ dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10616759", "map_id": "none", "name": "NOX4, NOX5 reduce O2 to O2.-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10616756", "map_id": "none", "name": "NOX4, NOX5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10623544", "map_id": "none", "name": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10603066", "map_id": "none", "name": "PRDX5 reduces peroxynitrite to nitrite using TXN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_3697881", "map_id": "CHEBI:25941", "name": "Peroxynitrite", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_3697842", "map_id": "CHEBI:16301", "name": "Nitrite", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10602650", "map_id": "Q54N76", "name": "PRDX5-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0285741", "map_id": "DDB_G0285741", "name": "PRDX5-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10603197", "map_id": "none", "name": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space" }, { "id": "species_189481", "map_id": "CHEBI:16240", "name": "H2O2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10603194", "map_id": "none", "name": "SOD1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "reaction_10581788", "map_id": "none", "name": "2 H2O2 => O2 + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_10581785", "map_id": "none", "name": "CAT tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "O77229", "map_id": "O77229", "name": "catA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274595", "map_id": "DDB_G0274595", "name": "catA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10602655", "map_id": "none", "name": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10602652", "map_id": "none", "name": "PRDX3,5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54W09", "map_id": "Q54W09", "name": "PRDX3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279973", "map_id": "DDB_G0279973", "name": "PRDX3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54N76", "map_id": "Q54N76", "name": "PRDX5-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10602686", "map_id": "none", "name": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602683", "map_id": "none", "name": "PRDX6:GSTP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q556P3", "map_id": "Q556P3", "name": "GSTP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273153", "map_id": "DDB_G0273153", "name": "GSTP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FF3", "map_id": "Q55FF3", "name": "gsta1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268138", "map_id": "DDB_G0268138", "name": "gsta1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86AU1", "map_id": "Q86AU1", "name": "gsta4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274263", "map_id": "DDB_G0274263", "name": "gsta4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QV7", "map_id": "Q54QV7", "name": "gsta5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283575", "map_id": "DDB_G0283575", "name": "gsta5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VI4", "map_id": "Q54VI4", "name": "gsta3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280317", "map_id": "DDB_G0280317", "name": "gsta3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q556G3", "map_id": "Q556G3", "name": "gsta2-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272632", "map_id": "DDB_G0272632", "name": "gsta2-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SE2", "map_id": "Q54SE2", "name": "PRDX6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282517", "map_id": "DDB_G0282517", "name": "PRDX6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10600900", "map_id": "none", "name": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1131972", "map_id": "CHEBI:16960", "name": "ADP-D-ribose", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_73578", "map_id": "CHEBI:78679", "name": "R5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10600897", "map_id": "none", "name": "NUDT5 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54S89", "map_id": "Q54S89", "name": "NUDT5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282603", "map_id": "DDB_G0282603", "name": "NUDT5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10577424", "map_id": "none", "name": "RFC binding displaces Pol Alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10577420", "map_id": "none", "name": "RFC Heteropentamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54BN3", "map_id": "Q54BN3", "name": "rfc3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293702", "map_id": "DDB_G0293702", "name": "rfc3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54E21", "map_id": "Q54E21", "name": "rfc2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291868", "map_id": "DDB_G0291868", "name": "rfc2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ST4", "map_id": "Q54ST4", "name": "rfc5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282235", "map_id": "DDB_G0282235", "name": "rfc5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MD4", "map_id": "Q54MD4", "name": "rfc4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286027", "map_id": "DDB_G0286027", "name": "rfc4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MH9", "map_id": "Q54MH9", "name": "rfc1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285961", "map_id": "DDB_G0285961", "name": "rfc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10577245", "map_id": "none", "name": "RNA primer-DNA primer:origin duplex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10577422", "map_id": "none", "name": "RFC Heteropentamer:RNA primer-DNA primer:origin duplex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10577462", "map_id": "none", "name": "Formation of Processive Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10577437", "map_id": "none", "name": "RNA primer-DNA primer:origin duplex:PCNA ", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10577435", "map_id": "none", "name": "Loading of PCNA - Sliding Clamp Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10577433", "map_id": "none", "name": "RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10577439", "map_id": "none", "name": "RFC dissociates after sliding clamp formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10618449", "map_id": "none", "name": "RAB33B:GTP binds RIC1:RGP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10618445", "map_id": "none", "name": "RIC1:RGP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54WR7", "map_id": "Q54WR7", "name": "RIC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279477", "map_id": "DDB_G0279477", "name": "RIC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q76NU4", "map_id": "Q76NU4", "name": "DG1122", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277397", "map_id": "DDB_G0277397", "name": "DG1122", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10618439", "map_id": "none", "name": "RAB33B:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "O76173", "map_id": "O76173", "name": "Rab1C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269174", "map_id": "DDB_G0269174", "name": "Rab1C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10618447", "map_id": "none", "name": "RAB33B:GTP:RIC1:RGP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10618433", "map_id": "none", "name": "CYTH proteins stimulate ARF1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10618424", "map_id": "none", "name": "ARF1:GTP:CYTH1,2,3,4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10618430", "map_id": "none", "name": "ARF1:GDP:CYTH1,2,3,4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10618612", "map_id": "none", "name": "The COG complex binds RABs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10617130", "map_id": "none", "name": "COG complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10618608", "map_id": "none", "name": "other COG-interacting RABs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q559X6", "map_id": "Q559X6", "name": "rab2B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272138", "map_id": "DDB_G0272138", "name": "rab2B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55ET3", "map_id": "Q55ET3", "name": "rabQ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268760", "map_id": "DDB_G0268760", "name": "rabQ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P36409", "map_id": "P36409", "name": "rab2A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292268", "map_id": "DDB_G0292268", "name": "rab2A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FK2", "map_id": "Q55FK2", "name": "rab6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268068", "map_id": "DDB_G0268068", "name": "rab6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10618610", "map_id": "none", "name": "COG complex:RABs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10618426", "map_id": "none", "name": "CYTH proteins bind ARF1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10618402", "map_id": "none", "name": "CYTH1,2,3,4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10618379", "map_id": "none", "name": "NSF and SNAPs bind the cis-SNARE at the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10618375", "map_id": "none", "name": "STX:PalmC-YKT6:BET1L:GOSR1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10618377", "map_id": "none", "name": "STX5:PalmC-YKT6:BET1L:GOSR1:NSF hexamer:3xSNAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10617758", "map_id": "none", "name": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10617754", "map_id": "none", "name": "other COG interacting snares", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q54CK6", "map_id": "Q54CK6", "name": "vti1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292974", "map_id": "DDB_G0292974", "name": "vti1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54R67", "map_id": "Q54R67", "name": "VTI1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283363", "map_id": "DDB_G0283363", "name": "VTI1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q551H5", "map_id": "Q551H5", "name": "STX16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276575", "map_id": "DDB_G0276575", "name": "STX16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PW2", "map_id": "Q54PW2", "name": "syn6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284185", "map_id": "DDB_G0284185", "name": "syn6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54I20", "map_id": "Q54I20", "name": "STX6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289063", "map_id": "DDB_G0289063", "name": "STX6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PQ5", "map_id": "Q54PQ5", "name": "STX6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GE3", "map_id": "Q54GE3", "name": "vps45", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290213", "map_id": "DDB_G0290213", "name": "vps45", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10617756", "map_id": "none", "name": "COG complex:Golgi snares", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10618382", "map_id": "none", "name": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "reaction_10606649", "map_id": "none", "name": "ADRM1:26S proteaseome binds UCHL5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10606638", "map_id": "Q54N38", "name": "uch2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0285527", "map_id": "DDB_G0285527", "name": "uch2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10606645", "map_id": "none", "name": "ADRM1:26S proteasome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q556N5", "map_id": "Q556N5", "name": "adrm1-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272624", "map_id": "DDB_G0272624", "name": "adrm1-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10606647", "map_id": "none", "name": "ADRM1:26S proteasome:UCHL5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54N38", "map_id": "Q54N38", "name": "uch2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10611049", "map_id": "none", "name": "UCHL1, UCHL3 cleave ubiquitin adducts", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10611044", "map_id": "none", "name": "UCHL1,UCHL3:Ub-Lys", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_1131871", "map_id": "CHEBI:32551", "name": "L-lysine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_459", "compartment_display": "cytoplasm", "complex": "false" }, { "id": "species_10611046", "map_id": "none", "name": "UCHL1,UCHL3:Ub", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10606686", "map_id": "none", "name": "ADRM1 binds 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10606643", "map_id": "Q556N5", "name": "adrm1-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10590556", "map_id": "none", "name": "Association of CCT/TriC with sphingosine kinase 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10590508", "map_id": "Q6B516", "name": "sgkB", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10590552", "map_id": "none", "name": "CCT/TRiC:ADP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55BM4", "map_id": "Q55BM4", "name": "tcp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269190", "map_id": "DDB_G0269190", "name": "tcp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TD3", "map_id": "Q54TD3", "name": "cct5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281849", "map_id": "DDB_G0281849", "name": "cct5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ER7", "map_id": "Q54ER7", "name": "cct7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291225", "map_id": "DDB_G0291225", "name": "cct7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q76NU3", "map_id": "Q76NU3", "name": "cct6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277493", "map_id": "DDB_G0277493", "name": "cct6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ES9", "map_id": "Q54ES9", "name": "cct2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291358", "map_id": "DDB_G0291358", "name": "cct2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CL2", "map_id": "Q54CL2", "name": "cct4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292872", "map_id": "DDB_G0292872", "name": "cct4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TH8", "map_id": "Q54TH8", "name": "cct3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281741", "map_id": "DDB_G0281741", "name": "cct3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q552J0", "map_id": "Q552J0", "name": "cct8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276233", "map_id": "DDB_G0276233", "name": "cct8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10590554", "map_id": "none", "name": "CCT/TRiC:ADP:Sphingosine kinase 1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q6B516", "map_id": "Q6B516", "name": "sgkB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617873", "map_id": "none", "name": "TRiC/CCT binds unfolded G-protein beta subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10589812", "map_id": "P36408", "name": "gpbA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0277143", "map_id": "DDB_G0277143", "name": "gpbA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10617871", "map_id": "none", "name": "Unfolded G-protein beta subunit:CCT/TRiC:ADP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P36408", "map_id": "P36408", "name": "gpbA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617879", "map_id": "none", "name": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10617877", "map_id": "none", "name": "Unfolded G-protein beta subunit:CCT/TRiC:ATP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10617881", "map_id": "none", "name": "ATP binds G-protein beta associated TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10611316", "map_id": "none", "name": "CECRI deaminates Ade-Rib to Ino", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_83908", "map_id": "CHEBI:16335", "name": "Ade-Rib", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_2022135", "map_id": "CHEBI:16134", "name": "NH3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_83921", "map_id": "CHEBI:17596", "name": "Ino", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10611313", "map_id": "none", "name": "CECR1:Zn2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q553U5", "map_id": "Q553U5", "name": "ADA2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275179", "map_id": "DDB_G0275179", "name": "ADA2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10608345", "map_id": "none", "name": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen" }, { "id": "species_5685882", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "false" }, { "id": "species_10608214", "map_id": "none", "name": "Homologues of pro-SFTPB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "true" }, { "id": "B0G0Z4", "map_id": "B0G0Z4", "name": "SFTPB(25-200)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292508", "map_id": "DDB_G0292508", "name": "SFTPB(25-200)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55C30", "map_id": "Q55C30", "name": "SFTPB(25-200)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54C60", "map_id": "Q54C60", "name": "sapA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293010", "map_id": "DDB_G0293010", "name": "sapA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55EI1", "map_id": "Q55EI1", "name": "SFTPB(25-200)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54D30", "map_id": "Q54D30", "name": "SFTPB(25-200)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86KA8", "map_id": "Q86KA8", "name": "SFTPB(25-200)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54F52", "map_id": "Q54F52", "name": "SFTPB(25-200)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LG3", "map_id": "Q54LG3", "name": "SFTPB(25-200)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SX7", "map_id": "Q54SX7", "name": "SFTPB(25-200)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WE4", "map_id": "Q54WE4", "name": "SFTPB(25-200)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10608286", "map_id": "none", "name": "Homologues of SFTPB(280-381)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "true" }, { "id": "species_10608238", "map_id": "none", "name": "Homologues of SFTPB(201-279)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "true" }, { "id": "species_10608262", "map_id": "none", "name": "Homologues of SFTPB(25-200)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "true" }, { "id": "species_10608342", "map_id": "none", "name": "NAPSA, CTSH, PGA3-5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "true" }, { "id": "O76856", "map_id": "O76856", "name": "ctsD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279411", "map_id": "DDB_G0279411", "name": "ctsD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10612937", "map_id": "none", "name": "SFTPB binds itself", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen" }, { "id": "species_10608347", "map_id": "none", "name": "SFTPB dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "true" }, { "id": "reaction_10626233", "map_id": "none", "name": "pro-SFTPB translocates from ER membrane to multivesicle body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10626231", "map_id": "none", "name": "Homologues of pro-SFTPB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10608074", "map_id": "none", "name": "ABCA3 transports PC, PG from ER membrane to lamellar body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_2133233", "compartment_display": "lamellar body membrane" }, { "id": "species_5684863", "map_id": "none", "name": "PC, PG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_5684869", "map_id": "none", "name": "PC, PG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_80738", "compartment_display": "lamellar body", "complex": "true" }, { "id": "species_10608071", "map_id": "none", "name": "Homologues of ABCA3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_2133233", "compartment_display": "lamellar body membrane", "complex": "true" }, { "id": "Q8T6J1", "map_id": "Q8T6J1", "name": "abcA6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291245", "map_id": "DDB_G0291245", "name": "abcA6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T6J2", "map_id": "Q8T6J2", "name": "abcA5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274119", "map_id": "DDB_G0274119", "name": "abcA5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T6J5", "map_id": "Q8T6J5", "name": "abcA2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267438", "map_id": "DDB_G0267438", "name": "abcA2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BT5", "map_id": "Q54BT5", "name": "abcA3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293436", "map_id": "DDB_G0293436", "name": "abcA3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q555Z5", "map_id": "Q555Z5", "name": "abcA4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274121", "map_id": "DDB_G0274121", "name": "abcA4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BC0", "map_id": "Q55BC0", "name": "abcA8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271138", "map_id": "DDB_G0271138", "name": "abcA8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T5Z7", "map_id": "Q8T5Z7", "name": "abcA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291994", "map_id": "DDB_G0291994", "name": "abcA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10592403", "map_id": "none", "name": "ZnT5 transports zinc into secretory granules in pancreatic beta cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen" }, { "id": "species_216785", "map_id": "CHEBI:29105", "name": "Zn2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen", "complex": "false" }, { "id": "species_10592400", "map_id": "none", "name": "Homologues of SLC30A5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_216813", "compartment_display": "secretory granule membrane", "complex": "true" }, { "id": "Q54F34", "map_id": "Q54F34", "name": "SLC30A5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291141", "map_id": "DDB_G0291141", "name": "SLC30A5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55E98", "map_id": "Q55E98", "name": "SLC30A5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10592411", "map_id": "none", "name": "SLC30A8 transports Zn2+ from cytosol to secretory granule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10592408", "map_id": "Q54QU8", "name": "SLC30A8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_216813", "compartment_display": "secretory granule membrane", "complex": "false" }, { "id": "DDB_G0283629", "map_id": "DDB_G0283629", "name": "SLC30A8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10589007", "map_id": "none", "name": "Exocyst complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10588988", "map_id": "Q54VZ8", "name": "exoc8", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0279991", "map_id": "DDB_G0279991", "name": "exoc8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10588973", "map_id": "Q54VX5", "name": "exoc2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0280081", "map_id": "DDB_G0280081", "name": "exoc2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10589003", "map_id": "Q558Z9", "name": "exoc7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0272991", "map_id": "DDB_G0272991", "name": "exoc7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10588968", "map_id": "Q54P76", "name": "exoc4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0284833", "map_id": "DDB_G0284833", "name": "exoc4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10588998", "map_id": "Q54BP6", "name": "exoc3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_216813", "compartment_display": "secretory granule membrane", "complex": "false" }, { "id": "DDB_G0293520", "map_id": "DDB_G0293520", "name": "exoc3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10588983", "map_id": "Q54B27", "name": "exoc6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0293936", "map_id": "DDB_G0293936", "name": "exoc6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10588978", "map_id": "B0G163", "name": "exoc5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0287881", "map_id": "DDB_G0287881", "name": "exoc5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10588993", "map_id": "Q54NV1", "name": "exoc1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0285067", "map_id": "DDB_G0285067", "name": "exoc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10589005", "map_id": "none", "name": "Exocyst Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54NV1", "map_id": "Q54NV1", "name": "exoc1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B0G163", "map_id": "B0G163", "name": "exoc5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54B27", "map_id": "Q54B27", "name": "exoc6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BP6", "map_id": "Q54BP6", "name": "exoc3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54P76", "map_id": "Q54P76", "name": "exoc4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q558Z9", "map_id": "Q558Z9", "name": "exoc7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VX5", "map_id": "Q54VX5", "name": "exoc2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VZ8", "map_id": "Q54VZ8", "name": "exoc8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599268", "map_id": "none", "name": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10599262", "map_id": "none", "name": "Signal Recognition Particle", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q556L1", "map_id": "Q556L1", "name": "srp14-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272590", "map_id": "DDB_G0272590", "name": "srp14-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54EP7", "map_id": "Q54EP7", "name": "srp72", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291412", "map_id": "DDB_G0291412", "name": "srp72", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GL2", "map_id": "Q55GL2", "name": "srp9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267622", "map_id": "DDB_G0267622", "name": "srp9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q554G7", "map_id": "Q554G7", "name": "srp19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275211", "map_id": "DDB_G0275211", "name": "srp19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q75K18", "map_id": "Q75K18", "name": "srp54", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275455", "map_id": "DDB_G0275455", "name": "srp54", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXE8", "map_id": "Q1ZXE8", "name": "srp68", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285821", "map_id": "DDB_G0285821", "name": "srp68", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10599264", "map_id": "none", "name": "ribosome:mRNA:polypeptide+signal", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54G86", "map_id": "Q54G86", "name": "rpl23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290315", "map_id": "DDB_G0290315", "name": "rpl23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XI5", "map_id": "Q54XI5", "name": "rpl9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278959", "map_id": "DDB_G0278959", "name": "rpl9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54X53", "map_id": "Q54X53", "name": "rpl21", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279387", "map_id": "DDB_G0279387", "name": "rpl21", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P13023", "map_id": "P13023", "name": "rpl8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274113", "map_id": "DDB_G0274113", "name": "rpl8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P14329", "map_id": "P14329", "name": "rpl19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281565", "map_id": "DDB_G0281565", "name": "rpl19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ZD1", "map_id": "Q54ZD1", "name": "rpl7a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277629", "map_id": "DDB_G0277629", "name": "rpl7a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MK8", "map_id": "Q54MK8", "name": "rpl18a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285881", "map_id": "DDB_G0285881", "name": "rpl18a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P11874", "map_id": "P11874", "name": "rpl7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276441", "map_id": "DDB_G0276441", "name": "rpl7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VZ4", "map_id": "Q54VZ4", "name": "rpl18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279997", "map_id": "DDB_G0279997", "name": "rpl18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54D63", "map_id": "Q54D63", "name": "rpl6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292460", "map_id": "DDB_G0292460", "name": "rpl6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NG2", "map_id": "Q54NG2", "name": "rpl17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285277", "map_id": "DDB_G0285277", "name": "rpl17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34113", "map_id": "P34113", "name": "rpl3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291862", "map_id": "DDB_G0291862", "name": "rpl3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TW3", "map_id": "Q54TW3", "name": "rpl29", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281469", "map_id": "DDB_G0281469", "name": "rpl29", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QM8", "map_id": "Q54QM8", "name": "rpl26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283741", "map_id": "DDB_G0283741", "name": "rpl26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GS21", "map_id": "Q9GS21", "name": "rpl28", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282379", "map_id": "DDB_G0282379", "name": "rpl28", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GK6", "map_id": "Q54GK6", "name": "rpl22a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290091", "map_id": "DDB_G0290091", "name": "rpl22a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P48160", "map_id": "P48160", "name": "rpl27a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292388", "map_id": "DDB_G0292388", "name": "rpl27a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BE6", "map_id": "Q55BE6", "name": "rpl27", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271298", "map_id": "DDB_G0271298", "name": "rpl27", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VN6", "map_id": "Q54VN6", "name": "rpl24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280229", "map_id": "DDB_G0280229", "name": "rpl24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BQ3", "map_id": "Q54BQ3", "name": "rpl23a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293502", "map_id": "DDB_G0293502", "name": "rpl23a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54J69", "map_id": "Q54J69", "name": "rpl10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288273", "map_id": "DDB_G0288273", "name": "rpl10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P22683", "map_id": "P22683", "name": "rplp2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283393", "map_id": "DDB_G0283393", "name": "rplp2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AQ9", "map_id": "Q55AQ9", "name": "rpl36", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271668", "map_id": "DDB_G0271668", "name": "rpl36", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BN7", "map_id": "Q55BN7", "name": "rpl35a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270424", "map_id": "DDB_G0270424", "name": "rpl35a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P22684", "map_id": "P22684", "name": "rplp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277907", "map_id": "DDB_G0277907", "name": "rplp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P22685", "map_id": "P22685", "name": "rplp0", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286501", "map_id": "DDB_G0286501", "name": "rplp0", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": 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"name": "rpl30", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270380", "map_id": "DDB_G0270380", "name": "rpl30", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XX3", "map_id": "Q54XX3", "name": "rpl5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278539", "map_id": "DDB_G0278539", "name": "rpl5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86K01", "map_id": "Q86K01", "name": "rpl15-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272893", "map_id": "DDB_G0272893", "name": "rpl15-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Z09", "map_id": "Q54Z09", "name": "rpl14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277975", "map_id": "DDB_G0277975", "name": "rpl14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q553M7", "map_id": "Q553M7", "name": "rpl13a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275881", "map_id": "DDB_G0275881", "name": "rpl13a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54E20", "map_id": "Q54E20", "name": "rpl13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291870", "map_id": "DDB_G0291870", "name": "rpl13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Z69", "map_id": "Q54Z69", "name": "rpl4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277803", "map_id": "DDB_G0277803", "name": "rpl4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54J50", "map_id": "Q54J50", "name": "rpl12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288295", "map_id": "DDB_G0288295", "name": "rpl12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P16168", "map_id": "P16168", "name": "rpl11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279189", "map_id": "DDB_G0279189", "name": "rpl11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GJ7", "map_id": "Q55GJ7", "name": "rpl38", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268302", "map_id": "DDB_G0268302", "name": "rpl38", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MG6", "map_id": "Q54MG6", "name": "rpl37", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285971", "map_id": "DDB_G0285971", "name": "rpl37", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86L05", "map_id": "Q86L05", "name": "rpl10a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276871", "map_id": "DDB_G0276871", "name": "rpl10a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10599266", "map_id": "none", "name": "SRP:polypeptide+signal:ribosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10583761", "map_id": "none", "name": "Regeneration of eEF1A:GTP by eEF1B activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10583756", "map_id": "none", "name": "eEF1A:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10583752", "map_id": "none", "name": "eEF1B complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9GRF8", "map_id": "Q9GRF8", "name": "efa1B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284035", "map_id": "DDB_G0284035", "name": "efa1B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B0G141", "map_id": "B0G141", "name": "efa1G", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282979", "map_id": "DDB_G0282979", "name": "efa1G", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10583758", "map_id": "none", "name": "eEF1B:GDP exchange complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10583738", "map_id": "none", "name": "eEF1A:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10583771", "map_id": "none", "name": "GTP-binding activates eEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10583767", "map_id": "P15112", "name": "efbA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0288373", "map_id": "DDB_G0288373", "name": "efbA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10583769", "map_id": "none", "name": "eEF2:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P15112", "map_id": "P15112", "name": "efbA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10583754", "map_id": "none", "name": "Formation of eEF1B complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10583743", "map_id": "Q9GRF8", "name": "efa1B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10583750", "map_id": "B0G141", "name": "efa1G", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10583745", "map_id": "Q9GRF8", "name": "efa1B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10583720", "map_id": "none", "name": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10583711", "map_id": "none", "name": "43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54YJ6", "map_id": "Q54YJ6", "name": "eif1a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278205", "map_id": "DDB_G0278205", "name": "eif1a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54EQ1", "map_id": "Q54EQ1", "name": "eif3K", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291404", "map_id": "DDB_G0291404", "name": "eif3K", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QW1", "map_id": "Q54QW1", "name": "eif3B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283597", "map_id": "DDB_G0283597", "name": "eif3B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86LA2", "map_id": "Q86LA2", "name": "eif3L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272076", "map_id": "DDB_G0272076", "name": "eif3L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54UD0", "map_id": "Q54UD0", "name": "eif3H", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281153", "map_id": "DDB_G0281153", "name": "eif3H", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KZ8", "map_id": "Q54KZ8", "name": "eif3m", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287005", "map_id": "DDB_G0287005", "name": "eif3m", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86B20", "map_id": "Q86B20", "name": "eif3A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272078", "map_id": "DDB_G0272078", "name": "eif3A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KI0", "map_id": "Q54KI0", "name": "eif3J", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287333", "map_id": "DDB_G0287333", "name": "eif3J", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q554U9", "map_id": "Q554U9", "name": "eif3d", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274627", "map_id": "DDB_G0274627", "name": "eif3d", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MT0", "map_id": "Q54MT0", "name": "eif3I", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285683", "map_id": "DDB_G0285683", "name": "eif3I", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54X97", "map_id": "Q54X97", "name": "eif3C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279109", "map_id": "DDB_G0279109", "name": "eif3C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WM4", "map_id": "Q54WM4", "name": "eif3G", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279549", "map_id": "DDB_G0279549", "name": "eif3G", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CC5", "map_id": "Q54CC5", "name": "eif3E", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293052", "map_id": "DDB_G0293052", "name": "eif3E", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54C49", "map_id": "Q54C49", "name": "eif3f", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293254", "map_id": "DDB_G0293254", "name": "eif3f", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10583716", "map_id": "Q553M7", "name": "phospho-rpl13a", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10583718", "map_id": "none", "name": "phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10583724", "map_id": "none", "name": "Dissociation of L13a from the 60s ribosomal subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10580367", "map_id": "none", "name": "60S ribosomal complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10583722", "map_id": "none", "name": "60s ribosomal complex lacking L13a subunit", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10580149", "map_id": "Q553M7", "name": "rpl13a", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10580065", "map_id": "none", "name": "Formation of the cap-binding eIF4F complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10580029", "map_id": "Q553R3", "name": "eif4g", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10580024", "map_id": "Q55FE0", "name": "eif4e", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10580019", "map_id": "none", "name": "eIF4A subunits complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10580031", "map_id": "none", "name": "eIF4F", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10583713", "map_id": "none", "name": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10583709", "map_id": "Q54BM2", "name": "pabpc1A", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10583704", "map_id": "none", "name": "Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10580008", "map_id": "none", "name": "43S complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10579985", "map_id": "Q54YJ6", "name": "eif1a", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10583773", "map_id": "none", "name": "Formation of translation initiation complexes containing mRNA that does not circularize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10580071", "map_id": "none", "name": "mRNA:eIF4F:eIF4B:eIF4H", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10580040", "map_id": "none", "name": "48S complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10580074", "map_id": "none", "name": "Cap-bound mRNA is activated by helicases ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10580038", "map_id": "Q75K16", "name": "EIF4H", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10580036", "map_id": "Q75K16", "name": "EIF4B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10580069", "map_id": "none", "name": "eIF4F:mRNP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_72595", "map_id": "none", "name": "RNA-binding protein in RNP (ribonucleoprotein) complexes", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10580063", "map_id": "none", "name": "Release of eIF4E from the inactive eIF4E:4E-BP complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10580061", "map_id": "none", "name": "eIF4E:4E-BP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54DU8", "map_id": "Q54DU8", "name": "febA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291990", "map_id": "DDB_G0291990", "name": "febA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10580059", "map_id": "Q54DU8", "name": "febA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10580054", "map_id": "none", "name": "Ribosomal scanning ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_72617", "map_id": "none", "name": "eIF1", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10580396", "map_id": "none", "name": "Start codon recognition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10580045", "map_id": "Q54LA1", "name": "eif5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0286753", "map_id": "DDB_G0286753", "name": "eif5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10580002", "map_id": "none", "name": "EIF2S1:EIF2S2:EIF2S3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10580394", "map_id": "none", "name": "Formation of the 43S pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10580390", "map_id": "none", "name": "40S:eIF3:eIF1A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10580006", "map_id": "none", "name": "ternary complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10580076", "map_id": "none", "name": "De novo formation of eIF2:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10580078", "map_id": "none", "name": "Met-tRNAi binds to eIF2:GTP to form the ternary complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_72393", "map_id": "none", "name": "Met-tRNAi", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10580384", "map_id": "none", "name": "eIF5B:GTP is hydrolyzed and released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10580378", "map_id": "none", "name": "80S:Met-tRNAi:mRNA:eIF5B:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54XP6", "map_id": "Q54XP6", "name": "eif5b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278815", "map_id": "DDB_G0278815", "name": "eif5b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10580382", "map_id": "none", "name": "80S:Met-tRNAi:mRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10580380", "map_id": "none", "name": "eIF5B:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10580051", "map_id": "none", "name": "eIF2:GTP is hydrolyzed, eIFs are released ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10580047", "map_id": "none", "name": "40S:Met-tRNAi:mRNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10579980", "map_id": "none", "name": "eIF3 subunits complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10580386", "map_id": "none", "name": "The 60S subunit joins the translation initiation complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10580376", "map_id": "none", "name": "eIF5B:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10580388", "map_id": "none", "name": "Release of 40S and 60S subunits from the 80S ribosome ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10580369", "map_id": "none", "name": "80S ribosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10580392", "map_id": "none", "name": "eIF3 and eIF1A bind to the 40S subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10593013", "map_id": "none", "name": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10593010", "map_id": "none", "name": "PPA2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54PV8", "map_id": "Q54PV8", "name": "ppa1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284265", "map_id": "DDB_G0284265", "name": "ppa1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_109496", "map_id": "CHEBI:18420", "name": "Mg2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10578737", "map_id": "none", "name": "pyrophosphate + H2O => 2 orthophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10578734", "map_id": "none", "name": "PPA1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10601713", "map_id": "none", "name": "SENP1,2,5 proteolytically process SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10601709", "map_id": "Q54SX2", "name": "SUMO3(1-103)", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10601711", "map_id": "Q54SX2", "name": "SUMO3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10601673", "map_id": "none", "name": "SENP1,2,5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10601685", "map_id": "none", "name": "SENP1,2,5 proteolytically process SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10601681", "map_id": "Q54SX2", "name": "SUMO2(1-95)", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10601683", "map_id": "Q54SX2", "name": "SUMO2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10601676", "map_id": "none", "name": "SENP1,2,5 proteolytically process SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10601662", "map_id": "none", "name": "Homologues of SUMO1(2-101)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10601746", "map_id": "none", "name": "Transfer of SUMO1 from E1 to UBE2I (UBC9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10601653", "map_id": "none", "name": "SUMO1:UBA2:SAE1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54L40", "map_id": "Q54L40", "name": "uba2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286919", "map_id": "DDB_G0286919", "name": "uba2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WI4", "map_id": "Q54WI4", "name": "sae1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279641", "map_id": "DDB_G0279641", "name": "sae1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10601638", "map_id": "none", "name": "UBA2:SAE1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10601656", "map_id": "none", "name": "Conjugation of SUMO1 to UBA2:SAE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10603971", "map_id": "none", "name": "SUMOylation of Histone H4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10581418", "map_id": "Q76NW2", "name": "H4b", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10603969", "map_id": "none", "name": "SUMO1:HIST1H4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10604098", "map_id": "none", "name": "SUMOylation of HDAC2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10603140", "map_id": "Q55FN5", "name": "hdaA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10604096", "map_id": "none", "name": "SUMO1:HDAC2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10604058", "map_id": "none", "name": "SUMOylation of HDAC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604056", "map_id": "none", "name": "2SUMO1:HDAC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10603949", "map_id": "none", "name": "SUMOylation of Histone H4 with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10601799", "map_id": "none", "name": "SUMO3:UBE2I", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10603947", "map_id": "Q76NW2", "name": "H4b", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10603395", "map_id": "none", "name": "PIAS1 SUMOylates DDX5 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10579094", "map_id": "Q54CE0", "name": "ddx17", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10603392", "map_id": "Q54CE0", "name": "ddx17", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10603490", "map_id": "none", "name": "SUMOylation of DAXX with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10602165", "map_id": "Q54WP8", "name": "DAXX", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0279509", "map_id": "DDB_G0279509", "name": "SUMO1-K630,K631-DAXX", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10603488", "map_id": "none", "name": "2SUMO1:DAXX", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54WP8", "map_id": "Q54WP8", "name": "SUMO1-K630,K631-DAXX", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10603511", "map_id": "none", "name": "TOPORS SUMOylates SIN3A with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10590689", "map_id": "Q54UJ3", "name": "SIN3A", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10603503", "map_id": "none", "name": "SUMO1:SIN3A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10603508", "map_id": "Q54UA7", "name": "TOPORS", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0281183", "map_id": "DDB_G0281183", "name": "SUMO1-K560-TOPORS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10603528", "map_id": "none", "name": "SUMOylation of ING2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10603526", "map_id": "none", "name": "SUMO1:ING2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10603563", "map_id": "none", "name": "SUMOylation of HIPK2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10603548", "map_id": "Q54QV3", "name": "yakA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0283605", "map_id": "DDB_G0283605", "name": "yakA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10603561", "map_id": "none", "name": "SUMO1:HIPK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54QV3", "map_id": "Q54QV3", "name": "yakA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10603389", "map_id": "none", "name": "SUMOylation of DDX5 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10603387", "map_id": "none", "name": "SUMO1:DDX5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10603374", "map_id": "none", "name": "SUMOylation of DDX17 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10603354", "map_id": "none", "name": "Homologues of DDX17", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54CB8", "map_id": "Q54CB8", "name": "SUMO1-K50-DDX17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293064", "map_id": "DDB_G0293064", "name": "SUMO1-K50-DDX17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10603372", "map_id": "none", "name": "SUMO1:DDX17", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10604146", "map_id": "none", "name": "SUMOylation of TOP2B with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604127", "map_id": "none", "name": "Homologues of TOP2B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P90520", "map_id": "P90520", "name": "top2mt", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279737", "map_id": "DDB_G0279737", "name": "top2mt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BP5", "map_id": "Q55BP5", "name": "top2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270418", "map_id": "DDB_G0270418", "name": "top2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10604144", "map_id": "none", "name": "SUMO1:TOP2B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10604151", "map_id": "none", "name": "PIAS4 SUMOylates TOP2A with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10601801", "map_id": "none", "name": "UBE2I:SUMO2,UBE2I:SUMO3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10604103", "map_id": "Q55BP5", "name": "top2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10604149", "map_id": "Q55BP5", "name": "top2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10601810", "map_id": "none", "name": "Homologues of PIAS4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10604118", "map_id": "none", "name": "SUMOylation of TOP2A with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604116", "map_id": "none", "name": "SUMO1:TOP2A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10604075", "map_id": "none", "name": "SUMOylation of PCNA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10577429", "map_id": "Q54K47", "name": "pcna", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10604073", "map_id": "none", "name": "SUMO1:PCNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10604171", "map_id": "none", "name": "SUMOylation of TOP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604156", "map_id": "Q54RC3", "name": "top1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0283205", "map_id": "DDB_G0283205", "name": "top1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10604169", "map_id": "none", "name": "SUMO1:TOP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54RC3", "map_id": "Q54RC3", "name": "top1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10604001", "map_id": "none", "name": "SUMOylation of MDC1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10603996", "map_id": "Q86IG6", "name": "MDC1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0272690", "map_id": "DDB_G0272690", "name": "MDC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10603999", "map_id": "Q86IG6", "name": "SUMO2,3-K1840-MDC1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10603872", "map_id": "none", "name": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10603852", "map_id": "Q54YJ7", "name": "xrcc4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10603865", "map_id": "none", "name": "SUMO1:XRCC4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10603869", "map_id": "none", "name": "PIAS1,2-1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10603847", "map_id": "none", "name": "PIAS4 SUMOylates PARP1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10600664", "map_id": "none", "name": "Homologues of PARP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10603845", "map_id": "none", "name": "Homologues of SUMO2,3-K203,K486-PARP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10601830", "map_id": "none", "name": "PIAS1,4 SUMOylates BRCA1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10601773", "map_id": "Q54C05", "name": "BRCA1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0293300", "map_id": "DDB_G0293300", "name": "SUMO2,3-BRCA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10601828", "map_id": "none", "name": "SUMO1:BRCA1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54C05", "map_id": "Q54C05", "name": "SUMO2,3-BRCA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10601812", "map_id": "none", "name": "PIAS1,4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10603718", "map_id": "none", "name": "PIAS4 SUMOylates PARP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10603716", "map_id": "none", "name": "2SUMO1:PARP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10601901", "map_id": "none", "name": "UBE2I, HDAC7 SUMOylate PML with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10601869", "map_id": "Q54MF7", "name": "PML", "type": "inhibitor", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10601884", "map_id": "none", "name": "3SUMO1:PML", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10601898", "map_id": "none", "name": "UBE2I,HDAC7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54VQ7", "map_id": "Q54VQ7", "name": "hdaC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280195", "map_id": "DDB_G0280195", "name": "hdaC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10602028", "map_id": "none", "name": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10601093", "map_id": "none", "name": "Cohesin Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10601992", "map_id": "none", "name": "SUMOylated Cohesin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10602025", "map_id": "none", "name": "SMC5-SMC6 Complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54HN3", "map_id": "Q54HN3", "name": "NSMCE2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289341", "map_id": "DDB_G0289341", "name": "NSMCE2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54T56", "map_id": "Q54T56", "name": "EID3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281991", "map_id": "DDB_G0281991", "name": "EID3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FE3", "map_id": "Q54FE3", "name": "smc5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290919", "map_id": "DDB_G0290919", "name": "smc5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54X37", "map_id": "Q54X37", "name": "NSMCE1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279231", "map_id": "DDB_G0279231", "name": "NSMCE1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54I56", "map_id": "Q54I56", "name": "smc6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288993", "map_id": "DDB_G0288993", "name": "smc6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10603823", "map_id": "none", "name": "PIAS4 SUMOylates HERC2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10603779", "map_id": "none", "name": "Homologues of HERC2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54Q89", "map_id": "Q54Q89", "name": "HERC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284033", "map_id": "DDB_G0284033", "name": "HERC2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MP76", "map_id": "Q8MP76", "name": "HERC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54R64", "map_id": "Q54R64", "name": "HERC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54S74", "map_id": "Q54S74", "name": "HERC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SA3", "map_id": "Q54SA3", "name": "HERC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WU2", "map_id": "Q54WU2", "name": "HERC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CR5", "map_id": "Q55CR5", "name": "HERC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DD2", "map_id": "Q55DD2", "name": "HERC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B0G136", "map_id": "B0G136", "name": "HERC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GN7", "map_id": "Q55GN7", "name": "HERC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10603821", "map_id": "none", "name": "SUMO1:HERC2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10603889", "map_id": "none", "name": "SUMOylation of RAD52 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10603887", "map_id": "none", "name": "3SUMO1:RAD52", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10604016", "map_id": "none", "name": "SUMOylation of MDC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604014", "map_id": "none", "name": "SUMO1:MDC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q86IG6", "map_id": "Q86IG6", "name": "MDC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10601815", "map_id": "none", "name": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10601804", "map_id": "Q54C05", "name": "SUMO2,3-BRCA1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10603991", "map_id": "none", "name": "SUMOylation of XPC with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10603976", "map_id": "Q1ZXA6", "name": "rad4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0292296", "map_id": "DDB_G0292296", "name": "rad4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10603989", "map_id": "none", "name": "SUMO1:XPC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q1ZXA6", "map_id": "Q1ZXA6", "name": "rad4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10601914", "map_id": "none", "name": "SUMOylation of PML with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10601911", "map_id": "Q54MF7", "name": "SUMO3-K65,K160,K490-PML", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10603903", "map_id": "none", "name": "SUMOylation of BLM with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10603894", "map_id": "Q54DM3", "name": "BLM", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10603900", "map_id": "Q54DM3", "name": "4SUMO2,3-BLM", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10602897", "map_id": "none", "name": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10602878", "map_id": "none", "name": "Homologues of MTA1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q1ZXA2", "map_id": "Q1ZXA2", "name": "mybS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293468", "map_id": "DDB_G0293468", "name": "mybS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MS4", "map_id": "Q54MS4", "name": "SUMO2,3-K509-MTA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285693", "map_id": "DDB_G0285693", "name": "SUMO2,3-K509-MTA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10602886", "map_id": "none", "name": "Homologues of SUMO2,3-K509-MTA1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10602894", "map_id": "none", "name": "PIAS1,3,4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10601851", "map_id": "none", "name": "PIAS4 SUMOylates TP53BP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10601835", "map_id": "Q54LN0", "name": "TP53BP1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0286539", "map_id": "DDB_G0286539", "name": "SUMO1-K-TP53BP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10601848", "map_id": "none", "name": "SUMO1:TP53BP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54LN0", "map_id": "Q54LN0", "name": "SUMO1-K-TP53BP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10603474", "map_id": "none", "name": "SUMOylation of UBE2I with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10603472", "map_id": "none", "name": "SUMO1:K14-UBE2I", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10603446", "map_id": "none", "name": "SUMOylation of PIAS4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10603444", "map_id": "none", "name": "SUMO1:PIAS4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10603757", "map_id": "none", "name": "SUMOylation of TOPORS with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10603755", "map_id": "none", "name": "SUMO1:TOPORS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54UA7", "map_id": "Q54UA7", "name": "SUMO1-K560-TOPORS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10620075", "map_id": "none", "name": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29424", "map_id": "CHEBI:57305", "name": "Gly", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10620063", "map_id": "none", "name": "Polyglycylated microtubule", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10620072", "map_id": "none", "name": "TTLL3,TTLL8,TTLL10", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54TU1", "map_id": "Q54TU1", "name": "TTLL8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281541", "map_id": "DDB_G0281541", "name": "TTLL8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10623090", "map_id": "none", "name": "RNF152 polyubiquitinates RRAGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10623077", "map_id": "none", "name": "Ub:UBE2N", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10623079", "map_id": "none", "name": "RNF152:RRAGA:GDP:Ub:UBE2N", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "Q54L05", "map_id": "Q54L05", "name": "TRIM32", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286991", "map_id": "DDB_G0286991", "name": "TRIM32", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10623087", "map_id": "none", "name": "K63polyUb-K142,K220,K230,K244-RRAGA:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10623070", "map_id": "Q54L05", "name": "RNF152", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "species_10587616", "map_id": "Q86K32", "name": "ube2n", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10623282", "map_id": "none", "name": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10623255", "map_id": "Q54KQ4", "name": "SHPRH", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0287171", "map_id": "DDB_G0287171", "name": "SHPRH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10623270", "map_id": "none", "name": "Ub:UBE2N:UBE2V2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10623264", "map_id": "none", "name": "RAD18:UBE2B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54XR0", "map_id": "Q54XR0", "name": "rad18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278935", "map_id": "DDB_G0278935", "name": "rad18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10612435", "map_id": "none", "name": "MonoUb:K164-PCNA homotrimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10623272", "map_id": "none", "name": "SHPRH:monoUb:K164-PCNA:RAD18:UBE2B:Ub:UBE2N:UBE2V2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54KQ4", "map_id": "Q54KQ4", "name": "SHPRH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10623906", "map_id": "none", "name": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10623900", "map_id": "none", "name": "PEX5S,L:PEX13:PEX14:PEX2:PEX10:PEX12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "Q54CL3", "map_id": "Q54CL3", "name": "pex13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292870", "map_id": "DDB_G0292870", "name": "pex13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54C55", "map_id": "Q54C55", "name": "pex14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293264", "map_id": "DDB_G0293264", "name": "pex14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54S31", "map_id": "Q54S31", "name": "pex10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282693", "map_id": "DDB_G0282693", "name": "pex10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54N40", "map_id": "Q54N40", "name": "pex12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285523", "map_id": "DDB_G0285523", "name": "pex12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10623902", "map_id": "none", "name": "Ub:UBE2D1,2,3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10623904", "map_id": "none", "name": "PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10623280", "map_id": "none", "name": "SHPRH polyubiquitinates monoubiquitinated PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10623277", "map_id": "none", "name": "K63polyUb-K164-PCNA homotrimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10608545", "map_id": "none", "name": "UBE2N:UBE2V2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10623062", "map_id": "none", "name": "RNF144A binds PRKDC and Ubiquitin:UBE2L3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10623047", "map_id": "Q54UC0", "name": "dnapkcs", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10623056", "map_id": "none", "name": "Homologues of RNF144A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "Q54QC7", "map_id": "Q54QC7", "name": "RNF144A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283939", "map_id": "DDB_G0283939", "name": "RNF144A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10623058", "map_id": "none", "name": "Ub:UBE2L3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10623060", "map_id": "none", "name": "RNF144A:PRKDC:Ub:UBE2L3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10623092", "map_id": "none", "name": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10623072", "map_id": "none", "name": "RRAGA:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10623306", "map_id": "none", "name": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10623299", "map_id": "none", "name": "Homologues of HLTF", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54T24", "map_id": "Q54T24", "name": "helE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281949", "map_id": "DDB_G0281949", "name": "helE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B0G105", "map_id": "B0G105", "name": "HLTF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282115", "map_id": "DDB_G0282115", "name": "HLTF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SZ4", "map_id": "Q54SZ4", "name": "HLTF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10623301", "map_id": "none", "name": "HLTF:monoUb:K164-PCNA:RAD18:UBE2B:Ub:UBE2N:UBE2V2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10623304", "map_id": "none", "name": "HLTF polyubiquitinates monoubiquitinated PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10623068", "map_id": "none", "name": "RNF144A polyubiquitinates PRKDC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10596492", "map_id": "Q54TE1", "name": "UBE2L3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10623065", "map_id": "Q54UC0", "name": "dnapkcs", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10623916", "map_id": "none", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10623913", "map_id": "none", "name": "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "species_10577361", "map_id": "none", "name": "Homologues of UBE2D1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10619202", "map_id": "none", "name": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10576913", "map_id": "none", "name": "Homologues of RPS27A(1-76)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10579845", "map_id": "none", "name": "Homologues of RPS27A(77-156)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10619199", "map_id": "none", "name": "UCHL3,USP7,USP9X", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q869U4", "map_id": "Q869U4", "name": "USP7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276443", "map_id": "DDB_G0276443", "name": "USP7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10619233", "map_id": "none", "name": "OTULIN,USP5 cleaves UBC yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10619230", "map_id": "none", "name": "Homologues of UBC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10577007", "map_id": "none", "name": "Homologues of UBC(457-532)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10577021", "map_id": "none", "name": "Homologues of UBC(533-608)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10577035", "map_id": "none", "name": "Homologues of UBC(609-684)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10576923", "map_id": "none", "name": "Homologues of UBC(1-76)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10576937", "map_id": "none", "name": "Homologues of UBC(77-152)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10576951", "map_id": "none", "name": "Homologues of UBC(153-228)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10576965", "map_id": "none", "name": "Homologues of UBC(229-304)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10576979", "map_id": "none", "name": "Homologues of UBC(305-380)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10576993", "map_id": "none", "name": "Homologues of UBC(381-456)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10610786", "map_id": "P54201", "name": "ubpA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0291239", "map_id": "DDB_G0291239", "name": "ubpA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10619237", "map_id": "none", "name": "OTULIN,USP5 cleaves UBB yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10619235", "map_id": "P14797", "name": "ubqC", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10576919", "map_id": "P14797", "name": "ubqC", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10576917", "map_id": "P14797", "name": "ubqC", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10576915", "map_id": "P14797", "name": "ubqC", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10619151", "map_id": "none", "name": "UBA1 conjugates ubiquitin to nuclear E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10619115", "map_id": "none", "name": "E2 ubiquitin conjugating enzyme (UBA1 substrate)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54F00", "map_id": "Q54F00", "name": "Ub-C86-UBE2T", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291199", "map_id": "DDB_G0291199", "name": "Ub-C86-UBE2T", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55EY8", "map_id": "Q55EY8", "name": "ube2w", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268938", "map_id": "DDB_G0268938", "name": "ube2w", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VG3", "map_id": "Q54VG3", "name": "UBE2G2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280347", "map_id": "DDB_G0280347", "name": "UBE2G2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10619098", "map_id": "none", "name": "Ub-Cys632-UBA1:ubiquitin adenylate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10619149", "map_id": "none", "name": "Ub:E2 (UBA1 substrate)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10619064", "map_id": "none", "name": "UBA1:ubiquitin adenylate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10618924", "map_id": "none", "name": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618888", "map_id": "none", "name": "Ub-Cys625-UBA6:ubiquitin adenylate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q550P6", "map_id": "Q550P6", "name": "UBA6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277047", "map_id": "DDB_G0277047", "name": "UBA6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10618890", "map_id": "none", "name": "E2 ubiquitin conjugating enzyme (UBA6 substrate)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q555G0", "map_id": "Q555G0", "name": "UBE2Z", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274897", "map_id": "DDB_G0274897", "name": "UBE2Z", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10618892", "map_id": "none", "name": "UBA6:ubiquitin adenylate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10618922", "map_id": "none", "name": "Ub:E2 (UBA6 substrate)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10619216", "map_id": "none", "name": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10619214", "map_id": "none", "name": "Homologues of UBA52(1-128)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10580280", "map_id": "none", "name": "Homologues of RPL40", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10619153", "map_id": "none", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10619096", "map_id": "none", "name": "Ub-Cys632-UBA1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10619094", "map_id": "none", "name": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10619068", "map_id": "none", "name": "E2 ubiquitin conjugating enzyme (UBA1 substrate)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54VW9", "map_id": "Q54VW9", "name": "UBE2H", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280091", "map_id": "DDB_G0280091", "name": "UBE2H", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q75JE1", "map_id": "Q75JE1", "name": "UBE2G1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271726", "map_id": "DDB_G0271726", "name": "UBE2G1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10619072", "map_id": "none", "name": "Ub-Cys632-UBA1:ubiquitin adenylate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10619092", "map_id": "none", "name": "Ub:E2 (UBA1 substrate)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10619074", "map_id": "none", "name": "UBA1:ubiquitin adenylate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10619159", "map_id": "none", "name": "UBA1 conjugates ubiquitin to UBA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10619070", "map_id": "none", "name": "Ub-Cys632-UBA1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10619156", "map_id": "none", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10619162", "map_id": "none", "name": "UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10596583", "map_id": "Q55C16", "name": "uba1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10619066", "map_id": "none", "name": "UBA1 adenylates ubiquitin in the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10618926", "map_id": "Q55C16", "name": "uba1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10619164", "map_id": "none", "name": "UBA1 conjugates ubiquitin to UBA1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10594387", "map_id": "none", "name": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10594356", "map_id": "none", "name": "Tn antigens", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "Q54KS2", "map_id": "Q54KS2", "name": "Core 8 (MUC4)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287193", "map_id": "DDB_G0287193", "name": "Core 8 (MUC4)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ZU4", "map_id": "Q54ZU4", "name": "Core 8 (MUC19)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277357", "map_id": "DDB_G0277357", "name": "Core 8 (MUC19)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10594385", "map_id": "none", "name": "Core 5 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10594407", "map_id": "none", "name": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10594405", "map_id": "none", "name": "Core 6 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10594441", "map_id": "none", "name": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_735700", "map_id": "CHEBI:16650", "name": "UDP-GalNAc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10594439", "map_id": "none", "name": "Core 7 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10594397", "map_id": "none", "name": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_735682", "map_id": "CHEBI:18307", "name": "UDP-Gal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10594395", "map_id": "none", "name": "Core 8 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10603666", "map_id": "none", "name": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_4419987", "map_id": "CHEBI:17407", "name": "E,E-FPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_4419982", "map_id": "CHEBI:37531", "name": "pPPP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10603663", "map_id": "none", "name": "DHDDS:NUS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54EN3", "map_id": "Q54EN3", "name": "DHDDS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291436", "map_id": "DDB_G0291436", "name": "DHDDS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AK1", "map_id": "Q55AK1", "name": "NUS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271830", "map_id": "DDB_G0271830", "name": "NUS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10603674", "map_id": "none", "name": "SRD5A3 reduces pPNOL to DCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_4419981", "map_id": "CHEBI:67132", "name": "pPNOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_449221", "map_id": "CHEBI:16091", "name": "DCHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10592733", "map_id": "none", "name": "DOLK phosphorylates DCHOL to DOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_110094", "map_id": "CHEBI:17239", "name": "CDP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10592730", "map_id": "Q54MS7", "name": "DOLK", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0285689", "map_id": "DDB_G0285689", "name": "DOLK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10592749", "map_id": "none", "name": "DOLPP1 dephosphorylates DOLDP to DOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_449744", "map_id": "CHEBI:15750", "name": "DOLDP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10592746", "map_id": "Q86IX2", "name": "dolpp1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0274591", "map_id": "DDB_G0274591", "name": "dolpp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10592768", "map_id": "none", "name": "PMM1,2 isomerise Man6P to Man1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_532562", "map_id": "CHEBI:17369", "name": "Man6P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_532531", "map_id": "CHEBI:35374", "name": "Man1P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10592765", "map_id": "none", "name": "PMM1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54X03", "map_id": "Q54X03", "name": "pmmA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279289", "map_id": "DDB_G0279289", "name": "pmmA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86B09", "map_id": "Q86B09", "name": "pmmB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272781", "map_id": "DDB_G0272781", "name": "pmmB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10593934", "map_id": "none", "name": "MPI isomerises Fru6P to Man6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10593931", "map_id": "Q54PA0", "name": "mpi", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0284685", "map_id": "DDB_G0284685", "name": "mpi", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10592802", "map_id": "none", "name": "Synthesis of dolichyl-phosphate-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_29410", "map_id": "CHEBI:18066", "name": "UDP-Glc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_532214", "map_id": "CHEBI:15812", "name": "DbGP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_110096", "map_id": "CHEBI:17659", "name": "UDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10592799", "map_id": "Q54J42", "name": "alg5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0288321", "map_id": "DDB_G0288321", "name": "alg5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10591655", "map_id": "none", "name": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_428040", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_428639", "map_id": "CHEBI:17012", "name": "Neu5Ac", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_428633", "map_id": "CHEBI:17012", "name": "Neu5Ac", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10591652", "map_id": "Q54W37", "name": "SLC17A5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "DDB_G0280761", "map_id": "DDB_G0280761", "name": "SLC17A3(1-498)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10612709", "map_id": "none", "name": "FUK phosphorylates beta-Fuc to Fuc1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6787678", "map_id": "CHEBI:42589", "name": "beta-Fuc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6787542", "map_id": "CHEBI:12387", "name": "Fuc1P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10612706", "map_id": "Q55DE9", "name": "FUK", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0269678", "map_id": "DDB_G0269678", "name": "FUK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10612727", "map_id": "none", "name": "GMDS dehydrates GDP-Man to GDP-DHDMan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6787618", "map_id": "CHEBI:16955", "name": "GDP-DHDMan", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10612724", "map_id": "Q1ZXF7", "name": "gmd", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0284553", "map_id": "DDB_G0284553", "name": "gmd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10594121", "map_id": "none", "name": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_742368", "map_id": "CHEBI:17009", "name": "GDP-Fuc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_205683", "map_id": "CHEBI:17009", "name": "GDP-Fuc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10594118", "map_id": "Q550W6", "name": "slc35c1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "DDB_G0277007", "map_id": "DDB_G0277007", "name": "slc35c1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10612730", "map_id": "none", "name": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6787646", "map_id": "CHEBI:86476", "name": "GDP-KDGal", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10612716", "map_id": "none", "name": "TSTA3 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55C77", "map_id": "Q55C77", "name": "ger", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270184", "map_id": "DDB_G0270184", "name": "ger", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10612701", "map_id": "none", "name": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10612698", "map_id": "Q54NH4", "name": "FPGT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0285257", "map_id": "DDB_G0285257", "name": "FPGT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10612719", "map_id": "none", "name": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10592786", "map_id": "none", "name": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29494", "map_id": "CHEBI:15713", "name": "UTP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_532204", "map_id": "CHEBI:7125", "name": "AcGlcN1P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_162756", "map_id": "CHEBI:16264", "name": "UDP-GlcNAc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10592783", "map_id": "none", "name": "2xUAP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54GN5", "map_id": "Q54GN5", "name": "uap1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290055", "map_id": "DDB_G0290055", "name": "uap1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10593001", "map_id": "none", "name": "Acetylation of glucosamine 6-phosphate to GlcNAc6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_449701", "map_id": "CHEBI:15873", "name": "GlcN6P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_449703", "map_id": "CHEBI:15784", "name": "AcGlcN6P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10592998", "map_id": "none", "name": "2xGNPNAT1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54WR8", "map_id": "Q54WR8", "name": "gna1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279475", "map_id": "DDB_G0279475", "name": "gna1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10592991", "map_id": "none", "name": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29472", "map_id": "CHEBI:58359", "name": "L-Gln", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10592988", "map_id": "none", "name": "GFPT1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54LK1", "map_id": "Q54LK1", "name": "GFPT2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286603", "map_id": "DDB_G0286603", "name": "GFPT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10592725", "map_id": "none", "name": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_449222", "map_id": "CHEBI:18278", "name": "GlcNAcDOLDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10592722", "map_id": "P0CD61", "name": "alg7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0290751", "map_id": "DDB_G0290751", "name": "alg7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10592741", "map_id": "none", "name": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_449229", "map_id": "CHEBI:15809", "name": "DOLP-Man", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_449312", "map_id": "CHEBI:59088", "name": "(GlcNAc)2 (Man)7 (PP-Dol)1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_449311", "map_id": "CHEBI:16214", "name": "DOLP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_449365", "map_id": "CHEBI:59091", "name": "(GlcNAc)2 (Man)8 (PP-Dol)1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10592738", "map_id": "Q55FZ9", "name": "alg12", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0267884", "map_id": "DDB_G0267884", "name": "alg12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10592706", "map_id": "B0G0Z6", "name": "mpdu1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0295677", "map_id": "DDB_G0295677", "name": "mpdu1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10592820", "map_id": "none", "name": "Addition of the first mannose to the N-glycan precursor by ALG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_449293", "map_id": "CHEBI:18341", "name": "N,N'-DCDOLDP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_449283", "map_id": "CHEBI:18396", "name": "MDCDD", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10592817", "map_id": "P90522", "name": "alg1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0286011", "map_id": "DDB_G0286011", "name": "alg1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10592708", "map_id": "none", "name": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_449298", "map_id": "CHEBI:53022", "name": "(GlcNAc)2 (Man)5 (PP-Dol)1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_449315", "map_id": "CHEBI:53023", "name": "(GlcNAc)2 (Man)6 (PP-Dol)1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10592700", "map_id": "Q55F69", "name": "alg3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0268238", "map_id": "DDB_G0268238", "name": "alg3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10592776", "map_id": "none", "name": "Addition of the first glucose to the N-glycan precursor by ALG6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_449371", "map_id": "CHEBI:37637", "name": "(GlcNAc)2 (Man)9 (PP-Dol)1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_532542", "map_id": "CHEBI:15812", "name": "DbGP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_449649", "map_id": "CHEBI:59081", "name": "(Glc)1 (GlcNAc)2 (Man)9 (PP-Dol)1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10592773", "map_id": "Q54QG6", "name": "alg6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0283841", "map_id": "DDB_G0283841", "name": "alg6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10592794", "map_id": "none", "name": "Addition of a second mannose to the N-glycan precursor by ALG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_449737", "map_id": "CHEBI:59085", "name": "(GlcNAc)2 (Man)2 (PP-Dol)1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10592791", "map_id": "Q7KWM5", "name": "alg2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0272730", "map_id": "DDB_G0272730", "name": "alg2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10592810", "map_id": "none", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10592807", "map_id": "Q54WW9", "name": "alg9", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0279349", "map_id": "DDB_G0279349", "name": "alg9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10592717", "map_id": "none", "name": "Addition of a second glucose to the N-glycan precursor by ALG8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_449638", "map_id": "CHEBI:53020", "name": "(Glc)2 (GlcNAc)2 (Man)9 (PP-Dol)1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10592714", "map_id": "Q554E2", "name": "alg8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0275261", "map_id": "DDB_G0275261", "name": "alg8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10592812", "map_id": "none", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "reaction_10619185", "map_id": "none", "name": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10596971", "map_id": "none", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_8853371", "map_id": "none", "name": "unfolded protein:GlcNAc", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8853381", "map_id": "none", "name": "GlcNAc (Man)9-5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_8853396", "map_id": "CHEBI:91280", "name": "alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_6799540", "map_id": "CHEBI:91284", "name": "alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:91283", "map_id": "CHEBI:91283", "name": "CHEBI:91283", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:91282", "map_id": "CHEBI:91282", "name": "CHEBI:91282", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:91281", "map_id": "CHEBI:91281", "name": "CHEBI:91281", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10619182", "map_id": "Q55G89", "name": "ENGASE", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0268520", "map_id": "DDB_G0268520", "name": "ENGASE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10596973", "map_id": "none", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10596969", "map_id": "none", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_927893", "compartment_display": "endoplasmic reticulum quality control compartment", "complex": "true" }, { "id": "reaction_10594300", "map_id": "none", "name": "Binding of ERp57", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10594296", "map_id": "none", "name": "unfolded protein:(Glc)1 (GlcNAc)2 (Man)9 (Asn)1:chaperone", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "CHEBI:59080", "map_id": "CHEBI:59080", "name": "CHEBI:59080", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BA8", "map_id": "Q55BA8", "name": "cnxA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271144", "map_id": "DDB_G0271144", "name": "cnxA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23858", "map_id": "Q23858", "name": "crtA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283539", "map_id": "DDB_G0283539", "name": "crtA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10594000", "map_id": "Q54EN4", "name": "pdi2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "DDB_G0291434", "map_id": "DDB_G0291434", "name": "pdi2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10594298", "map_id": "none", "name": "unfolded protein:(Glc)1 (GlcNAc)2 (Man)9 (Asn)1:chaperone:ERp57", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "Q54EN4", "map_id": "Q54EN4", "name": "pdi2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10595778", "map_id": "none", "name": "Trimming of mannoses on the alpha1,6 arm by MAN2A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_975819", "map_id": "CHEBI:60615", "name": "(GlcNAc)3 (Man)3 (Asn)1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10595775", "map_id": "none", "name": "MAN2:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q54KN4", "map_id": "Q54KN4", "name": "manF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287231", "map_id": "DDB_G0287231", "name": "manF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10596981", "map_id": "none", "name": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_975910", "map_id": "CHEBI:59520", "name": "NGP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_205689", "map_id": "CHEBI:17552", "name": "GDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_1028779", "map_id": "none", "name": "NGP:1,6-GlcNAc", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10596978", "map_id": "Q54Y16", "name": "FUT8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "DDB_G0278473", "map_id": "DDB_G0278473", "name": "FUT8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10611509", "map_id": "none", "name": "FUT3 transfers L-fucose to Gal1,3GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_5693930", "map_id": "CHEBI:18915", "name": "Gal1,3GlcNAc group", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_5693933", "map_id": "CHEBI:18914", "name": "Gal1,3Fuc1,4GlcNAc group", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10611506", "map_id": "none", "name": "Homologues of FUT3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q54PK0", "map_id": "Q54PK0", "name": "FUT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284775", "map_id": "DDB_G0284775", "name": "FUT3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86J24", "map_id": "Q86J24", "name": "FUT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54P60", "map_id": "Q54P60", "name": "FUT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PH9", "map_id": "Q54PH9", "name": "fut1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284467", "map_id": "DDB_G0284467", "name": "fut1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PK3", "map_id": "Q54PK3", "name": "fut4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284551", "map_id": "DDB_G0284551", "name": "fut4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RA6", "map_id": "Q54RA6", "name": "FUT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PJ9", "map_id": "Q54PJ9", "name": "FUT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10611469", "map_id": "none", "name": "FUCA1 hydrolyses NGP:1,6-GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_6784247", "map_id": "none", "name": "NGP:1,6-GlcNAc", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_6784248", "map_id": "CHEBI:59520", "name": "NGP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_6784249", "map_id": "CHEBI:2181", "name": "L-fucose", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10611466", "map_id": "none", "name": "FUCA1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "P10901", "map_id": "P10901", "name": "alfA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274391", "map_id": "DDB_G0274391", "name": "alfA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q551C1", "map_id": "Q551C1", "name": "FUCA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276661", "map_id": "DDB_G0276661", "name": "FUCA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10595786", "map_id": "none", "name": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_981613", "map_id": "none", "name": "Glycoprotein with bifurcating GlcNAc in position 3", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10595783", "map_id": "Q559V4", "name": "gnt7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "DDB_G0272422", "map_id": "DDB_G0272422", "name": "gnt7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10620710", "map_id": "none", "name": "FarC-PTP4A2 binds RABGGTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10620704", "map_id": "none", "name": "Homologues of FarC-PTP4A2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54DU9", "map_id": "Q54DU9", "name": "FarC-PTP4A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292024", "map_id": "DDB_G0292024", "name": "FarC-PTP4A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86IL4", "map_id": "Q86IL4", "name": "FarC-PTP4A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10620706", "map_id": "B0G172", "name": "rabggtb", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10620708", "map_id": "none", "name": "FarC-PTP4A2:RABGGTB", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10620725", "map_id": "none", "name": "RGGT binds the RAB-binding subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1131164", "map_id": "CHEBI:48861", "name": "geranylgeranyl diphosphate", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10620714", "map_id": "none", "name": "RABGGTA:RABGGTB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10620721", "map_id": "none", "name": "CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10620723", "map_id": "none", "name": "RABGGTA:RABGGTB:CHMs:GGPP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10621957", "map_id": "none", "name": "RGGT geranylgeranylates RAB proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10621130", "map_id": "none", "name": "RGGT:CHMs:RABs:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86JP3", "map_id": "Q86JP3", "name": "rab5A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271984", "map_id": "DDB_G0271984", "name": "rab5A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RY4", "map_id": "Q54RY4", "name": "rabV", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282899", "map_id": "DDB_G0282899", "name": "rabV", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P20790", "map_id": "P20790", "name": "rab8A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280043", "map_id": "DDB_G0280043", "name": "rab8A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXE7", "map_id": "Q1ZXE7", "name": "rabZ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286169", "map_id": "DDB_G0286169", "name": "rabZ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P20791", "map_id": "P20791", "name": "rab8B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276399", "map_id": "DDB_G0276399", "name": "rab8B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MXQ2", "map_id": "Q8MXQ2", "name": "rab32C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275675", "map_id": "DDB_G0275675", "name": "rab32C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXC0", "map_id": "Q1ZXC0", "name": "GGC-RAB38", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290827", "map_id": "DDB_G0290827", "name": "GGC-RAB38", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QR3", "map_id": "Q54QR3", "name": "rab32A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283603", "map_id": "DDB_G0283603", "name": "rab32A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P36412", "map_id": "P36412", "name": "rab11A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269238", "map_id": "DDB_G0269238", "name": "rab11A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86JP0", "map_id": "Q86JP0", "name": "RAB11B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0294583", "map_id": "DDB_G0294583", "name": "RAB11B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_1132084", "map_id": "CHEBI:33019", "name": "PPi(3-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10621952", "map_id": "none", "name": "CHMs:GGC-RABs:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10621954", "map_id": "none", "name": "RGGTA:RGGTB:GGPP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10620716", "map_id": "none", "name": "RABGGTA and RABGGTB bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10620712", "map_id": "Q55DQ4", "name": "rabggta", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10621132", "map_id": "none", "name": "RGGT:CHM binds RABs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10621128", "map_id": "none", "name": "RABs:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10583985", "map_id": "none", "name": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8855657", "map_id": "CHEBI:15935", "name": "N-acetylglucosaminyl-PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_8855661", "map_id": "CHEBI:24275", "name": "glucosaminyl-PI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_29416", "map_id": "CHEBI:15366", "name": "CH3COO-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10583982", "map_id": "Q54C64", "name": "pigl", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0293136", "map_id": "DDB_G0293136", "name": "pigl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10583923", "map_id": "none", "name": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10583920", "map_id": "none", "name": "GPI-GnT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q86K35", "map_id": "Q86K35", "name": "pigH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277289", "map_id": "DDB_G0277289", "name": "pigH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86JM6", "map_id": "Q86JM6", "name": "PIGP(26-158)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272006", "map_id": "DDB_G0272006", "name": "PIGP(26-158)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QB2", "map_id": "Q54QB2", "name": "PIGA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283965", "map_id": "DDB_G0283965", "name": "PIGA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54M40", "map_id": "Q54M40", "name": "pigC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286221", "map_id": "DDB_G0286221", "name": "pigC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WP5", "map_id": "Q54WP5", "name": "PIGQ-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279515", "map_id": "DDB_G0279515", "name": "PIGQ-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10583954", "map_id": "none", "name": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8855659", "map_id": "CHEBI:53056", "name": "mannose (a1-4) glucosaminyl-acyl-PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_8855663", "map_id": "none", "name": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10583951", "map_id": "Q54WY9", "name": "PIGN", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0279313", "map_id": "DDB_G0279313", "name": "PIGN", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10583938", "map_id": "none", "name": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8855660", "map_id": "CHEBI:77364", "name": "(ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10583935", "map_id": "none", "name": "PIGF:PIGG", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54PB0", "map_id": "Q54PB0", "name": "PIGF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284667", "map_id": "DDB_G0284667", "name": "PIGF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q551Y7", "map_id": "Q551Y7", "name": "PIGG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276251", "map_id": "DDB_G0276251", "name": "PIGG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10583977", "map_id": "none", "name": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8855665", "map_id": "CHEBI:52572", "name": "glucosaminyl-acyl-PI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_162872", "map_id": "CHEBI:16214", "name": "dolichyl phosphate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10583974", "map_id": "none", "name": "GPI mannosyltransferase I", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54QP2", "map_id": "Q54QP2", "name": "pigX", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283717", "map_id": "DDB_G0283717", "name": "pigX", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IA4", "map_id": "Q54IA4", "name": "pigm", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288899", "map_id": "DDB_G0288899", "name": "pigm", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10583993", "map_id": "none", "name": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8855667", "map_id": "CHEBI:53058", "name": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10583990", "map_id": "Q54UQ5", "name": "PIGV", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0280891", "map_id": "DDB_G0280891", "name": "PIGV", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10583962", "map_id": "none", "name": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8855656", "map_id": "CHEBI:53059", "name": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10583959", "map_id": "Q54PM5", "name": "PIGB", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0284435", "map_id": "DDB_G0284435", "name": "PIGB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10583946", "map_id": "none", "name": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8855664", "map_id": "none", "name": "mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10583943", "map_id": "Q1ZXB4", "name": "smp3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0291660", "map_id": "DDB_G0291660", "name": "smp3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10583871", "map_id": "none", "name": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_75967", "map_id": "CHEBI:37554", "name": "FACoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8855666", "map_id": "CHEBI:52572", "name": "glucosaminyl-acyl-PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10583868", "map_id": "Q54MC0", "name": "pigw", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0286111", "map_id": "DDB_G0286111", "name": "pigw", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10623183", "map_id": "none", "name": "GPLD1 hydrolyses GPI-anchors from proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10623153", "map_id": "none", "name": "GPI-anchored proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54WG1", "map_id": "Q54WG1", "name": "VNN1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279675", "map_id": "DDB_G0279675", "name": "VNN1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54I77", "map_id": "Q54I77", "name": "cleaved GPI-CPM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288963", "map_id": "DDB_G0288963", "name": "cleaved GPI-CPM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54G06", "map_id": "Q54G06", "name": "xpnpep1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290501", "map_id": "DDB_G0290501", "name": "xpnpep1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10623175", "map_id": "none", "name": "proteins with cleaved GPI-anchors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_2197633", "map_id": "CHEBI:16749", "name": "PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10623180", "map_id": "Q86AV9", "name": "pldG", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "DDB_G0276919", "map_id": "DDB_G0276919", "name": "pldG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10605201", "map_id": "none", "name": "DPH6 ligates ammonium to diphthine-EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605193", "map_id": "P15112", "name": "efbA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10605198", "map_id": "Q54Y82", "name": "DPH6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0278373", "map_id": "DDB_G0278373", "name": "DPH6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10605237", "map_id": "none", "name": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605217", "map_id": "P15112", "name": "efbA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_353106", "map_id": "CHEBI:17509", "name": "MTAD", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10605204", "map_id": "P15112", "name": "efbA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10605234", "map_id": "none", "name": "DPH1:DPH2:DPH3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7KWL8", "map_id": "Q7KWL8", "name": "DPH3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277061", "map_id": "DDB_G0277061", "name": "DPH3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PW5", "map_id": "Q54PW5", "name": "dph1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284257", "map_id": "DDB_G0284257", "name": "dph1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B0G132", "map_id": "B0G132", "name": "dph2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0295687", "map_id": "DDB_G0295687", "name": "dph2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10605215", "map_id": "none", "name": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605207", "map_id": "P15112", "name": "efbA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10605212", "map_id": "Q75JG8", "name": "dph5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0276115", "map_id": "DDB_G0276115", "name": "dph5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10612822", "map_id": "none", "name": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_6788753", "map_id": "CHEBI:86019", "name": "S-FARN-Cys", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6788758", "map_id": "CHEBI:87167", "name": "S-FARN-CME", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10612819", "map_id": "none", "name": "ICMT:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q558K8", "map_id": "Q558K8", "name": "icmt-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272799", "map_id": "DDB_G0272799", "name": "icmt-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10588135", "map_id": "none", "name": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10588102", "map_id": "P13651", "name": "eif5a", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0284861", "map_id": "DDB_G0284861", "name": "eif5a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10588123", "map_id": "P13651", "name": "eif5a", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10588132", "map_id": "none", "name": "DOHH:Fe++", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q556G4", "map_id": "Q556G4", "name": "dohh-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272634", "map_id": "DDB_G0272634", "name": "dohh-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10588118", "map_id": "none", "name": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_204628", "map_id": "CHEBI:15725", "name": "1,3-diaminopropane", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10588106", "map_id": "P13651", "name": "eif5a", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_204635", "map_id": "CHEBI:16610", "name": "SPM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10588115", "map_id": "none", "name": "DHPS tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54MQ7", "map_id": "Q54MQ7", "name": "dhps", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285725", "map_id": "DDB_G0285725", "name": "dhps", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10621975", "map_id": "none", "name": "OTUD3 deubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10621972", "map_id": "Q8T9S7", "name": "pteN", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10616721", "map_id": "Q55FY4", "name": "OTUD3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0267906", "map_id": "DDB_G0267906", "name": "OTUD3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10612360", "map_id": "none", "name": "YOD1 binds VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10612356", "map_id": "Q55BI3", "name": "yod1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0271346", "map_id": "DDB_G0271346", "name": "yod1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10612358", "map_id": "none", "name": "YOD1:VCP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55BI3", "map_id": "Q55BI3", "name": "yod1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P90532", "map_id": "P90532", "name": "cdcD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10611237", "map_id": "none", "name": "MYSM1 deubiquitinates Histone H2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10611232", "map_id": "none", "name": "MYSM1:EP300:KAT2B:Ub-histone H2A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54R05", "map_id": "Q54R05", "name": "KAT2B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283459", "map_id": "DDB_G0283459", "name": "KAT2B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54J55", "map_id": "Q54J55", "name": "mybX", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288285", "map_id": "DDB_G0288285", "name": "mybX", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q550R6", "map_id": "Q550R6", "name": "MYSM1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277033", "map_id": "DDB_G0277033", "name": "MYSM1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10611234", "map_id": "none", "name": "MYSM1:EP300:KAT2B:Histone H2A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10611958", "map_id": "none", "name": "STAMBPL1 is a deubiquitinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10584752", "map_id": "none", "name": "K63-Ub", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10611955", "map_id": "Q54Q40", "name": "DG1039", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0284037", "map_id": "DDB_G0284037", "name": "DG1039", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10611240", "map_id": "none", "name": "PSMD14 cleaves K63-linked ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10577042", "map_id": "Q86IJ1", "name": "psmD14", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10612001", "map_id": "none", "name": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10611992", "map_id": "none", "name": "USP17:PolyUb-RCE1, PolyUb-CDC25A, PolyUb-DDX58, PolyUb-IFIH1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54QM6", "map_id": "Q54QM6", "name": "phospho-cdc25", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86L44", "map_id": "Q86L44", "name": "helF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0294407", "map_id": "DDB_G0294407", "name": "helF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86J16", "map_id": "Q86J16", "name": "USP17L2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274827", "map_id": "DDB_G0274827", "name": "USP17L2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10611998", "map_id": "none", "name": "USP17L1,USP17L2:RCE1, CDC25A, DDX58, IFIH1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10609754", "map_id": "none", "name": "PolyUb", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10610823", "map_id": "none", "name": "USP16,USP21 deubiquitinate Histone H2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10610818", "map_id": "none", "name": "USP16,USP21:Ub-histone H2A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55EJ1", "map_id": "Q55EJ1", "name": "USP21", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268872", "map_id": "DDB_G0268872", "name": "USP21", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86KB3", "map_id": "Q86KB3", "name": "USP45", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274207", "map_id": "DDB_G0274207", "name": "USP45", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10610820", "map_id": "none", "name": "USP16,USP22:Histone H2A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10609766", "map_id": "none", "name": "ADRM1:26S proteaseome binds USP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10609762", "map_id": "Q55BC4", "name": "USP14", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0271264", "map_id": "DDB_G0271264", "name": "USP14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10609764", "map_id": "none", "name": "ADRM1:26S proteasome:USP14", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55BC4", "map_id": "Q55BC4", "name": "USP14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10610793", "map_id": "none", "name": "USP5 cleaves polyubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10610788", "map_id": "none", "name": "USP5:PolyUb", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P54201", "map_id": "P54201", "name": "ubpA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10610790", "map_id": "none", "name": "USP5:Ub", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10612299", "map_id": "none", "name": "USP19 deubiquitinates RNF123", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10612294", "map_id": "none", "name": "USP19:K63polyUb-RNF123", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "B0G199", "map_id": "B0G199", "name": "USP19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293770", "map_id": "DDB_G0293770", "name": "USP19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PQ7", "map_id": "Q54PQ7", "name": "USP19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54N05", "map_id": "Q54N05", "name": "RNF123", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285581", "map_id": "DDB_G0285581", "name": "RNF123", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10612296", "map_id": "none", "name": "USP19:RNF123", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10611978", "map_id": "none", "name": "USP25 deubiquitinates DDX58", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10611966", "map_id": "none", "name": "USP25:PolyUb-DDX58", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10611968", "map_id": "none", "name": "USP25:DDX58", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10612202", "map_id": "none", "name": "USP44 deubiquitinates CDC20", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10612197", "map_id": "none", "name": "USP44:PolyUb-CDC20", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10610745", "map_id": "none", "name": "PolyUb", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10612199", "map_id": "none", "name": "USP44:CDC20", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10612234", "map_id": "none", "name": "USP49 deubiquitinates H2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10612229", "map_id": "none", "name": "USP49:Ub-histone H2B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10612231", "map_id": "none", "name": "USP49:Histone H2B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10620654", "map_id": "none", "name": "USP4 deubiquitinate TRAF2,TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10620649", "map_id": "none", "name": "USP4:PolyUb-TRAF2, PolyUb-TRAF6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10620651", "map_id": "none", "name": "TRAF2, TRAF6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10611973", "map_id": "B0G199", "name": "USP4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10612268", "map_id": "none", "name": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10612261", "map_id": "none", "name": "USP37:RUVLB1:PSMC5:PolyUb-CCNA1,PolyUb-CCNA2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54C28", "map_id": "Q54C28", "name": "RUVBL1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293226", "map_id": "DDB_G0293226", "name": "RUVBL1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10612265", "map_id": "none", "name": "USP37:RUVLB1:PSMC5:CCNA1,CCNA2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10612468", "map_id": "none", "name": "USP17 deubiquitinates SUDS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10612463", "map_id": "none", "name": "USP17:K63polyUb-SUDS3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54PU3", "map_id": "Q54PU3", "name": "K63polyUb-SUDS3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284289", "map_id": "DDB_G0284289", "name": "K63polyUb-SUDS3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10610329", "map_id": "none", "name": "K63polyUb", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10612465", "map_id": "none", "name": "USP17:SUDS3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10612280", "map_id": "none", "name": "USP13 deubiquitinates BECN1,USP10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10612275", "map_id": "none", "name": "USP13:K63polyUb-BECN1,K63polyUb-USP10", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10612277", "map_id": "none", "name": "USP13:BECN1,USP10", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10612155", "map_id": "none", "name": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10612104", "map_id": "none", "name": "CYLD:K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54XX5", "map_id": "Q54XX5", "name": "phospho-p-S166-RIPK1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278535", "map_id": "DDB_G0278535", "name": "phospho-p-S166-RIPK1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10612152", "map_id": "none", "name": "TRAF2,TRAF6,IKBKG,RIPK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10610842", "map_id": "none", "name": "USP21 deubiquitinates RIPK1,DDX58", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10610835", "map_id": "none", "name": "USP21:PolyUb-RIPK1, PolyUb-DDX58", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10610839", "map_id": "none", "name": "USP21:RIPK1,DDX58", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10612029", "map_id": "none", "name": "USP12, USP26 deubiquitinate AR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10612022", "map_id": "none", "name": "USP12:WDR48:WDR20,USP26:PolyUb-AR", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54ZP5", "map_id": "Q54ZP5", "name": "WDR48", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277533", "map_id": "DDB_G0277533", "name": "WDR48", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54G37", "map_id": "Q54G37", "name": "usp12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290453", "map_id": "DDB_G0290453", "name": "usp12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54UB2", "map_id": "Q54UB2", "name": "WDR20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281319", "map_id": "DDB_G0281319", "name": "WDR20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10612026", "map_id": "none", "name": "USP12:WDR48:WDR20,USP26:AR", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10610748", "map_id": "none", "name": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10609773", "map_id": "none", "name": "USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q8T9S7", "map_id": "Q8T9S7", "name": "phospho-pteN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10609777", "map_id": "none", "name": "USP7:TP53,MDM2,MDM4,FOXO4,PTEN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10595007", "map_id": "none", "name": "CYLD mediated deubiquitination of DDX58 (RIG-I)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10595000", "map_id": "Q86L44", "name": "helF", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10595002", "map_id": "Q86L44", "name": "helF", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10595004", "map_id": "Q54ZW5", "name": "rps3a", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10609757", "map_id": "none", "name": "PARK2 autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10608777", "map_id": "none", "name": "Homologues of polyUb-PARK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10608751", "map_id": "none", "name": "ATXN3 family cleave Ub chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10608748", "map_id": "none", "name": "ATXN3,ATXN3L,JOSD1,JOSD2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55DI9", "map_id": "Q55DI9", "name": "JOSD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269646", "map_id": "DDB_G0269646", "name": "JOSD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10590032", "map_id": "none", "name": "IRE1 binds IRE1 forming dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10590020", "map_id": "Q55GJ2", "name": "ireA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0267650", "map_id": "DDB_G0267650", "name": "phospho-ireA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10590022", "map_id": "none", "name": "IRE1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q55GJ2", "map_id": "Q55GJ2", "name": "phospho-ireA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10590030", "map_id": "none", "name": "IRE1 dimer autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10590027", "map_id": "none", "name": "p-S724-IRE1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10590082", "map_id": "none", "name": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10590078", "map_id": "none", "name": "Homologues of ATF6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54Q90", "map_id": "Q54Q90", "name": "bzpL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284023", "map_id": "DDB_G0284023", "name": "bzpL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WU0", "map_id": "Q54WU0", "name": "bzpC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279439", "map_id": "DDB_G0279439", "name": "bzpC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10590052", "map_id": "none", "name": "Homologues of ATF6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10590886", "map_id": "none", "name": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10590058", "map_id": "none", "name": "Homologues of ATF6(1-419)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10590878", "map_id": "none", "name": "Homologues of ATF6(380-419)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10589991", "map_id": "none", "name": "Homologues of ATF6(1-380)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10590883", "map_id": "Q552N4", "name": "MBTPS2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "DDB_G0275939", "map_id": "DDB_G0275939", "name": "MBTPS2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10590072", "map_id": "none", "name": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10590064", "map_id": "none", "name": "Homologues of ATF6(420-670)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10590069", "map_id": "Q54SL5", "name": "MBTPS1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "DDB_G0282397", "map_id": "DDB_G0282397", "name": "MBTPS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10589999", "map_id": "none", "name": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10589997", "map_id": "none", "name": "Homologues of ATF6(1-380)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10590040", "map_id": "none", "name": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10590037", "map_id": "none", "name": "p-S52-EIF2S1:EIF2S2:EIF2S3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10590013", "map_id": "none", "name": "PERK dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54R98", "map_id": "Q54R98", "name": "EIF2AK2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283301", "map_id": "DDB_G0283301", "name": "EIF2AK2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10590015", "map_id": "none", "name": "Dimerization of PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10590004", "map_id": "Q54R98", "name": "EIF2AK3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10577620", "map_id": "none", "name": "Phosphorylation of Cdc25A at Ser-123 by Chk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10577539", "map_id": "Q54QM6", "name": "cdc25", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10577598", "map_id": "Q54QM6", "name": "phospho-cdc25", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10577617", "map_id": "Q54VI1", "name": "phospho-fhkE", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0280321", "map_id": "DDB_G0280321", "name": "phospho-fhkE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10577608", "map_id": "none", "name": "Phosphorylation of Cdc25A at Ser-123 by Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10577596", "map_id": "none", "name": "Proteolytic degradation of ubiquitinated-Cdc25A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10577594", "map_id": "none", "name": "Ub-p-S123-CDC25A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10626291", "map_id": "none", "name": "HEXB cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2162223", "map_id": "none", "name": "GlcNAc-GlcA-GlcNAc", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10598378", "map_id": "none", "name": "bHEXB", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10600527", "map_id": "none", "name": "HEXA cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10598376", "map_id": "none", "name": "HEXA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10612384", "map_id": "none", "name": "UVSSA:USP7 deubiquitinates ERCC6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10612375", "map_id": "none", "name": "Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54X62", "map_id": "Q54X62", "name": "ZNF830", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279177", "map_id": "DDB_G0279177", "name": "ZNF830", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TY2", "map_id": "Q54TY2", "name": "ERCC6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281441", "map_id": "DDB_G0281441", "name": "ERCC6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10612381", "map_id": "none", "name": "TC-NER pre-incision complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10612308", "map_id": "none", "name": "Active RNA Pol II complex transcribes lesion-containing DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10612301", "map_id": "none", "name": "Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_6781829", "map_id": "CHEBI:17972", "name": "ribonucleoside triphosphate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10612305", "map_id": "none", "name": "Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10612328", "map_id": "none", "name": "ERCC8 (CSA) binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10612315", "map_id": "none", "name": "Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10612324", "map_id": "none", "name": "ERCC8:DDB1:CUL4:RBX1:COP9 Signalosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10612326", "map_id": "none", "name": "Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10612330", "map_id": "none", "name": "ERCC6 binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10612313", "map_id": "Q54TY2", "name": "ERCC6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10612349", "map_id": "none", "name": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10612346", "map_id": "none", "name": "Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10612303", "map_id": "none", "name": "RNA Pol II initiates transcription from damaged DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10578887", "map_id": "none", "name": "RNA Polymerase II holoenzyme complex (unphosphorylated)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_5688114", "map_id": "none", "name": "Distorted dsDNA", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10590490", "map_id": "none", "name": "Dephosphorylation of AKT by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10590487", "map_id": "none", "name": "AKT", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10590274", "map_id": "none", "name": "PP2A", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10624161", "map_id": "none", "name": "LIPs hydrolyze TG to DAG and LCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_171126", "map_id": "CHEBI:17855", "name": "TAGs", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_174602", "map_id": "CHEBI:15904", "name": "LCFAs", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_174675", "map_id": "CHEBI:18035", "name": "DAGs", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10624158", "map_id": "none", "name": "digestive LIPs", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10591551", "map_id": "none", "name": "Proton-coupled di- and tri-peptide cotransport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_428037", "map_id": "none", "name": "Di-peptides/tri-peptides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:90799", "map_id": "CHEBI:90799", "name": "CHEBI:90799", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:47923", "map_id": "CHEBI:47923", "name": "CHEBI:47923", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_428026", "map_id": "none", "name": "Di-peptides/tri-peptides", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10591548", "map_id": "Q55G06", "name": "SLC15A2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0267874", "map_id": "DDB_G0267874", "name": "SLC15A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10581636", "map_id": "none", "name": "NTP Binds Active Site of RNA Polymerase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10581630", "map_id": "none", "name": "pol II open pre-initiation complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_30595", "map_id": "none", "name": "NTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10581634", "map_id": "none", "name": "Pol II initiation complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10581644", "map_id": "none", "name": "Newly Formed Phosphodiester Bond Stabilized and PPi Released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10581642", "map_id": "none", "name": "Pol II Initiation complex with phosphodiester-PPi intermediate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10580924", "map_id": "none", "name": "pol II transcription complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10581646", "map_id": "none", "name": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10581767", "map_id": "none", "name": "RNA Polymerase II Promoter Opening: First Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10581650", "map_id": "none", "name": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10581608", "map_id": "none", "name": "pol II transcription complex containing 3 Nucleotide long transcript", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10581648", "map_id": "none", "name": "pol II transcription complex containing 4 nucleotide long transcript", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10626119", "map_id": "none", "name": "Unwinding of DNA for the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10581611", "map_id": "none", "name": "Addition of the third nucleotide on the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10626121", "map_id": "none", "name": "Unwinding DNA for the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10582826", "map_id": "none", "name": "Addition of nucleotides between position +11 and +30", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10582331", "map_id": "none", "name": "pol II transcription complex containing 11 nucleotide long transcript", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10582333", "map_id": "none", "name": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10581677", "map_id": "none", "name": "pol II transcription complex containing 9 nucleotide long transcript", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10581679", "map_id": "none", "name": "Addition of Nucleotides 5 through 9 on the growing Transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10590450", "map_id": "none", "name": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389894", "map_id": "CHEBI:63803", "name": "trans-2,3-dehydropristanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389982", "map_id": "CHEBI:63914", "name": "3-hydroxypristanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10590437", "map_id": "none", "name": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389893", "map_id": "CHEBI:64039", "name": "(2S) Pristanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10590434", "map_id": "none", "name": "ACOX2:FAD, ACOXL:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "Q54LF1", "map_id": "Q54LF1", "name": "ACOXL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286669", "map_id": "DDB_G0286669", "name": "ACOXL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10590452", "map_id": "none", "name": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389996", "map_id": "CHEBI:15371", "name": "3-ketopristanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10590447", "map_id": "none", "name": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_10590444", "map_id": "none", "name": "ACOX3:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "Q8MMS1", "map_id": "Q8MMS1", "name": "ACOX3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277477", "map_id": "DDB_G0277477", "name": "ACOX3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10619972", "map_id": "none", "name": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_8866574", "map_id": "CHEBI:61560", "name": "dNTP(4-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_8866608", "map_id": "CHEBI:18274", "name": "2'-deoxynucleoside", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_8866567", "map_id": "CHEBI:18036", "name": "PPPi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10619969", "map_id": "none", "name": "SAMHD1:Zn2+ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "B0G107", "map_id": "B0G107", "name": "SAMHD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272484", "map_id": "DDB_G0272484", "name": "SAMHD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29892", "map_id": "CHEBI:16497", "name": "dGTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10601235", "map_id": "none", "name": "ITPA hydrolyses ITP to IMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2509836", "map_id": "CHEBI:16039", "name": "ITP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29602", "map_id": "CHEBI:17202", "name": "IMP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10601232", "map_id": "none", "name": "ITPA dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54LQ6", "map_id": "Q54LQ6", "name": "itpa", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286495", "map_id": "DDB_G0286495", "name": "itpa", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10581202", "map_id": "none", "name": "Hypoxanthine + H2O + O2 => Xanthine + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_113599", "map_id": "CHEBI:17368", "name": "Hyp", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_30064", "map_id": "CHEBI:17712", "name": "XAN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10581199", "map_id": "none", "name": "XDH dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:44074", "map_id": "CHEBI:44074", "name": "CHEBI:44074", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FB7", "map_id": "Q54FB7", "name": "xdh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291047", "map_id": "DDB_G0291047", "name": "xdh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10581222", "map_id": "none", "name": "Guanine + H2O => Xanthine + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_83956", "map_id": "CHEBI:16235", "name": "Gua", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10581219", "map_id": "none", "name": "GDA dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86AW9", "map_id": "Q86AW9", "name": "guaD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277743", "map_id": "DDB_G0277743", "name": "guaD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10601238", "map_id": "none", "name": "ITPA hydrolyses XTP to XMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2509848", "map_id": "CHEBI:10049", "name": "XTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111584", "map_id": "CHEBI:15652", "name": "XMP", "type": "inhibitor", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10601241", "map_id": "none", "name": "ITPA hydrolyses dITP to dIMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2509835", "map_id": "CHEBI:28807", "name": "dITP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_109330", "map_id": "CHEBI:28806", "name": "dIMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10581224", "map_id": "none", "name": "Xanthine + H2O + O2 => Urate + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30034", "map_id": "CHEBI:17775", "name": "urate", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10581212", "map_id": "none", "name": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500120", "map_id": "none", "name": "(d)GMP, (d)IMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:16192", "map_id": "CHEBI:16192", "name": "CHEBI:16192", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_500118", "map_id": "none", "name": "Gu-Rib, dG, Ino, dI", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:17172", "map_id": "CHEBI:17172", "name": "CHEBI:17172", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28997", "map_id": "CHEBI:28997", "name": "CHEBI:28997", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16750", "map_id": "CHEBI:16750", "name": "CHEBI:16750", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10581209", "map_id": "none", "name": "NT5C2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54XC1", "map_id": "Q54XC1", "name": "nt5c2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279053", "map_id": "DDB_G0279053", "name": "nt5c2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10612835", "map_id": "none", "name": "AK6 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_6788813", "map_id": "none", "name": "(d)NMPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "CHEBI:15918", "map_id": "CHEBI:15918", "name": "CHEBI:15918", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_109386", "map_id": "CHEBI:17713", "name": "2'-deoxyadenosine 5'-monophosphate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6788807", "map_id": "none", "name": "(d)NDPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "CHEBI:16174", "map_id": "CHEBI:16174", "name": "CHEBI:16174", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28846", "map_id": "CHEBI:28846", "name": "CHEBI:28846", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10612832", "map_id": "Q54Y03", "name": "AK6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0278493", "map_id": "DDB_G0278493", "name": "AK6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10582661", "map_id": "none", "name": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6788782", "map_id": "none", "name": "(d)NDPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_6788778", "map_id": "none", "name": "(d)NMPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10582658", "map_id": "none", "name": "AK5,7,8,9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54CT8", "map_id": "Q54CT8", "name": "adkB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292730", "map_id": "DDB_G0292730", "name": "adkB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QJ9", "map_id": "Q54QJ9", "name": "adkA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283805", "map_id": "DDB_G0283805", "name": "adkA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10582663", "map_id": "none", "name": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10580715", "map_id": "none", "name": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500071", "map_id": "none", "name": "(d)GMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_500077", "map_id": "none", "name": "(d)GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:28862", "map_id": "CHEBI:28862", "name": "CHEBI:28862", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10580712", "map_id": "Q54XF2", "name": "guk1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0279001", "map_id": "DDB_G0279001", "name": "guk1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10580555", "map_id": "none", "name": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_499997", "map_id": "none", "name": "dUMP, TMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_500742", "map_id": "CHEBI:17622", "name": "dUMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_109366", "map_id": "CHEBI:17013", "name": "TMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_499999", "map_id": "none", "name": "dUDP, TDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:28850", "map_id": "CHEBI:28850", "name": "CHEBI:28850", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:18075", "map_id": "CHEBI:18075", "name": "CHEBI:18075", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10580552", "map_id": "none", "name": "DTYMK dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54GN2", "map_id": "Q54GN2", "name": "dtymk", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290033", "map_id": "DDB_G0290033", "name": "dtymk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10593837", "map_id": "none", "name": "(d)NDP + ATP <=> (d)NTP + ADP (NME4)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_482803", "map_id": "none", "name": "(d)NDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_113581", "map_id": "CHEBI:456216", "name": "ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_482807", "map_id": "none", "name": "(d)NTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_500739", "map_id": "CHEBI:17625", "name": "dUTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_29604", "map_id": "CHEBI:16284", "name": "dATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_30185", "map_id": "CHEBI:16311", "name": "dCTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_30187", "map_id": "CHEBI:18077", "name": "dTTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10593834", "map_id": "none", "name": "NME4 hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "P34093", "map_id": "P34093", "name": "ndkM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279911", "map_id": "DDB_G0279911", "name": "ndkM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10582668", "map_id": "none", "name": "ADP + ADP <=> AMP + ATP [AK2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10582665", "map_id": "Q54QJ9", "name": "adkA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "reaction_10616659", "map_id": "none", "name": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6806885", "map_id": "CHEBI:16862", "name": "NDP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6806881", "map_id": "CHEBI:17326", "name": "NTP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10616656", "map_id": "none", "name": "NME1:NME3 heterohexamer, NME2P1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10580565", "map_id": "none", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10580562", "map_id": "none", "name": "CTPS tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54V77", "map_id": "Q54V77", "name": "ctps", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280567", "map_id": "DDB_G0280567", "name": "ctps", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10580407", "map_id": "none", "name": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500009", "map_id": "none", "name": "(d)CMP, UMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_500006", "map_id": "none", "name": "(d)CDP, UDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10580404", "map_id": "P20425", "name": "pyrK", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0287495", "map_id": "DDB_G0287495", "name": "pyrK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10593654", "map_id": "none", "name": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_482627", "map_id": "none", "name": "(d)NDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_482625", "map_id": "none", "name": "(d)NTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10593651", "map_id": "none", "name": "nucleoside diphosphate kinase 1A:5B heterohexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10612827", "map_id": "none", "name": "AK4 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6788802", "map_id": "none", "name": "(d)NMPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_6788801", "map_id": "none", "name": "(d)NDPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10612824", "map_id": "Q54CT8", "name": "adkB", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10593851", "map_id": "none", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10593848", "map_id": "none", "name": "CTPS2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10580575", "map_id": "none", "name": "dUTP + H2O => dUMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10580572", "map_id": "none", "name": "DUT trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54BW5", "map_id": "Q54BW5", "name": "dut", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293374", "map_id": "DDB_G0293374", "name": "dut", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10580545", "map_id": "none", "name": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_83928", "map_id": "CHEBI:17748", "name": "Thy-dRib", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10580542", "map_id": "none", "name": "TK1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q27564", "map_id": "Q27564", "name": "thyB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289179", "map_id": "DDB_G0289179", "name": "thyB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10580529", "map_id": "none", "name": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500829", "map_id": "none", "name": "Cyt-Rib, dC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:15698", "map_id": "CHEBI:15698", "name": "CHEBI:15698", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17562", "map_id": "CHEBI:17562", "name": "CHEBI:17562", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10580526", "map_id": "none", "name": "CDA tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54I82", "map_id": "Q54I82", "name": "cda", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288933", "map_id": "DDB_G0288933", "name": "cda", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10623936", "map_id": "none", "name": "UCKL1 phosphorylates urindine, cytidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500759", "map_id": "none", "name": "Cyt-Rib, Ura-Rib", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_500761", "map_id": "none", "name": "CMP, UMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10623933", "map_id": "Q8T154", "name": "udkB", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0274559", "map_id": "DDB_G0274559", "name": "udkB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10582628", "map_id": "none", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10582625", "map_id": "none", "name": "UCK2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55EL3", "map_id": "Q55EL3", "name": "udkA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269034", "map_id": "DDB_G0269034", "name": "udkA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T154", "map_id": "Q8T154", "name": "udkB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10580519", "map_id": "none", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10580516", "map_id": "none", "name": "UCK1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10581238", "map_id": "none", "name": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10580502", "map_id": "none", "name": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500828", "map_id": "none", "name": "(d)CMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10580499", "map_id": "none", "name": "DCK dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54YL2", "map_id": "Q54YL2", "name": "dak", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278191", "map_id": "DDB_G0278191", "name": "dak", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10582606", "map_id": "none", "name": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_500822", "map_id": "none", "name": "dC, Thy-dRib, dU", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_500823", "map_id": "none", "name": "dCMP, TMP, dUMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10582603", "map_id": "Q54YL2", "name": "dak", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10582353", "map_id": "none", "name": "AMP + H2O => IMP + NH4+ (AMPD)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10582350", "map_id": "none", "name": "AMPD tetramers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54DD0", "map_id": "Q54DD0", "name": "amdA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292266", "map_id": "DDB_G0292266", "name": "amdA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10581184", "map_id": "none", "name": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_500224", "map_id": "none", "name": "dA, dG, dI", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:17256", "map_id": "CHEBI:17256", "name": "CHEBI:17256", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_500222", "map_id": "none", "name": "dAMP, dGMP, dIMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10581181", "map_id": "none", "name": "DGUOK dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10582544", "map_id": "none", "name": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500173", "map_id": "none", "name": "Ade-Rib, dA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_83909", "map_id": "CHEBI:16335", "name": "Ade-Rib", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_500088", "map_id": "none", "name": "(d)AMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10582541", "map_id": "none", "name": "ADK", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54MB5", "map_id": "Q54MB5", "name": "adk", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286057", "map_id": "DDB_G0286057", "name": "adk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10581192", "map_id": "none", "name": "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH4+ (ADA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500172", "map_id": "none", "name": "Ino, dI", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10581189", "map_id": "Q54KF3", "name": "ada", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0287371", "map_id": "DDB_G0287371", "name": "ada", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10582554", "map_id": "none", "name": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500201", "map_id": "none", "name": "dA, dG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_500199", "map_id": "none", "name": "dAMP, dGMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10580768", "map_id": "none", "name": "GAR + 10-Formyl-THF => FGAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111338", "map_id": "CHEBI:18349", "name": "PRGA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_419151", "map_id": "CHEBI:15637", "name": "10-formyl-THF", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111354", "map_id": "CHEBI:18272", "name": "N-Formyl-GAR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111355", "map_id": "CHEBI:15635", "name": "THF", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10580754", "map_id": "Q54GJ2", "name": "purD", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0290121", "map_id": "DDB_G0290121", "name": "purD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10580771", "map_id": "none", "name": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111292", "map_id": "CHEBI:17284", "name": "PRA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10580723", "map_id": "none", "name": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10580720", "map_id": "P32073", "name": "guaA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0281551", "map_id": "DDB_G0281551", "name": "guaA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10580757", "map_id": "none", "name": "FGAM + ATP => AIR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111369", "map_id": "CHEBI:18413", "name": "FGAM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111370", "map_id": "CHEBI:28843", "name": "AIR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10582854", "map_id": "none", "name": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_35141", "map_id": "CHEBI:15919", "name": "ADS", "type": "inhibitor", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10582851", "map_id": "none", "name": "ADSS, ADSSL1 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P21900", "map_id": "P21900", "name": "purA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285429", "map_id": "DDB_G0285429", "name": "purA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10627338", "map_id": "none", "name": "IMPDH tetramers binds IMPDH inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9678719", "map_id": "none", "name": "IMPDH inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10580730", "map_id": "none", "name": "IMPDH1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54QQ0", "map_id": "Q54QQ0", "name": "impdh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283701", "map_id": "DDB_G0283701", "name": "impdh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10580733", "map_id": "none", "name": "IMPDH tetramers:IMPDH inhibitors", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10580746", "map_id": "none", "name": "FAICAR => IMP + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111427", "map_id": "CHEBI:18381", "name": "FAICAR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10580743", "map_id": "none", "name": "ATIC dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86L14", "map_id": "Q86L14", "name": "purH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277087", "map_id": "DDB_G0277087", "name": "purH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10580765", "map_id": "none", "name": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10580762", "map_id": "Q54JC8", "name": "purL", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0288145", "map_id": "DDB_G0288145", "name": "purL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10580749", "map_id": "none", "name": "AICAR + 10-Formyl-THF => FAICAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111409", "map_id": "CHEBI:18406", "name": "AICAR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10580735", "map_id": "none", "name": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10580433", "map_id": "none", "name": "CAD hexamer transforms CAP to N-carb-L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111647", "map_id": "CHEBI:17672", "name": "CAP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111628", "map_id": "CHEBI:15859", "name": "N-carb-L-Asp", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10580427", "map_id": "none", "name": "CAD hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P20054", "map_id": "P20054", "name": "pyr1-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276335", "map_id": "DDB_G0276335", "name": "pyr1-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10580417", "map_id": "none", "name": "UMPS dimer decarboxylates OMP to UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111629", "map_id": "CHEBI:15842", "name": "OMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10580414", "map_id": "none", "name": "UMPS dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P09556", "map_id": "P09556", "name": "pyr56", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280041", "map_id": "DDB_G0280041", "name": "pyr56", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10580436", "map_id": "none", "name": "CAD hexamer transforms L-Gln to CAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10580420", "map_id": "none", "name": "UMPS dimer transfers phoshoribosyl group to ORO to form OMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_73566", "map_id": "CHEBI:17111", "name": "PRPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_76632", "map_id": "CHEBI:16742", "name": "ORO", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10580430", "map_id": "none", "name": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_76630", "map_id": "CHEBI:17025", "name": "(S)-DHO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10611880", "map_id": "none", "name": "ADPGK:Mg2+ phosphorylates Glc to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10611877", "map_id": "none", "name": "ADPGK:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54K22", "map_id": "Q54K22", "name": "ADPGK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287631", "map_id": "DDB_G0287631", "name": "ADPGK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578788", "map_id": "none", "name": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30533", "map_id": "CHEBI:28602", "name": "D-Fructose 2,6-bisphosphate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10578785", "map_id": "none", "name": "PFKFB dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54SI2", "map_id": "Q54SI2", "name": "PFKFB2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282759", "map_id": "DDB_G0282759", "name": "PFKFB2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q551Y6", "map_id": "Q551Y6", "name": "PFKFB2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10577647", "map_id": "none", "name": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10577644", "map_id": "none", "name": "phosphoPFKFB1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10578671", "map_id": "none", "name": "phosphoenolpyruvate + ADP => pyruvate + ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29398", "map_id": "CHEBI:15361", "name": "PYR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10578668", "map_id": "none", "name": "pyruvate kinase tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54RF5", "map_id": "Q54RF5", "name": "pyk", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283247", "map_id": "DDB_G0283247", "name": "pyk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10613720", "map_id": "none", "name": "BPGM dimer isomerises 1,3BPG to 2,3BPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6798337", "map_id": "CHEBI:19324", "name": "2,3BPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10613717", "map_id": "none", "name": "BPGM dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10616029", "map_id": "none", "name": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10616026", "map_id": "none", "name": "GNPDA1,2 hexamers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54XK9", "map_id": "Q54XK9", "name": "gnpda1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278873", "map_id": "DDB_G0278873", "name": "gnpda1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10623996", "map_id": "none", "name": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8955759", "map_id": "CHEBI:18148", "name": "G1,6BP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10577658", "map_id": "none", "name": "PGM2L1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54UQ2", "map_id": "Q54UQ2", "name": "pgmB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280897", "map_id": "DDB_G0280897", "name": "pgmB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10606595", "map_id": "none", "name": "AKR1A1 reduces D-glucuronate to L-gulonate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5661264", "map_id": "CHEBI:15748", "name": "D-glucuronate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5661268", "map_id": "CHEBI:13115", "name": "L-gulonate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10606592", "map_id": "Q6IMN8", "name": "alrA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10626289", "map_id": "none", "name": "HEXB cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2065269", "map_id": "CHEBI:63516", "name": "ChEBI:63516 chain", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2105025", "map_id": "CHEBI:63873", "name": "IdoA-GalNAc(4S)-GlcA-Gal-Gal-Xyl", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10600151", "map_id": "none", "name": "HEXA cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "reaction_10599228", "map_id": "none", "name": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2104993", "map_id": "CHEBI:63868", "name": "CHEBI:63868 chain", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10594113", "map_id": "none", "name": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_158471", "map_id": "CHEBI:17980", "name": "PAPS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10594110", "map_id": "Q55DM5", "name": "slc35b2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "DDB_G0269602", "map_id": "DDB_G0269602", "name": "slc35b2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10591509", "map_id": "none", "name": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_427648", "map_id": "CHEBI:16189", "name": "SO4(2-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10591506", "map_id": "none", "name": "SLC26A1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "B0G157", "map_id": "B0G157", "name": "SLC26A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286611", "map_id": "DDB_G0286611", "name": "SLC26A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FK8", "map_id": "Q55FK8", "name": "SLC26A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598500", "map_id": "none", "name": "GLB1 hydrolyses a glycosaminoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2104997", "map_id": "CHEBI:63850", "name": "Gal-GlcNAc(S)-Gal-GlcNAc(S)-Gal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2104995", "map_id": "CHEBI:63851", "name": "GlcNAc(S)-Gal-GlcNAc(S)-Gal", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10598503", "map_id": "none", "name": "HEXA cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2105012", "map_id": "CHEBI:63852", "name": "GlcNAc-Gal-GlcNAc(S)-Gal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2105010", "map_id": "CHEBI:63853", "name": "Gal-GlcNAc(S)-Gal", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10626293", "map_id": "none", "name": "HEXB cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "reaction_10626002", "map_id": "none", "name": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9033790", "map_id": "CHEBI:139350", "name": "Type 2 chain", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_9605593", "map_id": "CHEBI:140911", "name": "LeX", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10625999", "map_id": "none", "name": "FUT4,5,9(10,11)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10626007", "map_id": "none", "name": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9605595", "map_id": "CHEBI:140917", "name": "Type 1 MSGG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_9605615", "map_id": "CHEBI:140914", "name": "sLeA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10626004", "map_id": "none", "name": "FUT3 transfers Fuc to Type 1 chains to form LeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9036984", "map_id": "CHEBI:140162", "name": "Type 1 chain", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_9605607", "map_id": "CHEBI:140878", "name": "LeA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10626009", "map_id": "none", "name": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9605649", "map_id": "CHEBI:140919", "name": "Type 1 DSGG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_9605651", "map_id": "CHEBI:140915", "name": "dsLeA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10626030", "map_id": "none", "name": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9605685", "map_id": "CHEBI:140918", "name": "Type 2 MSGG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_9605661", "map_id": "CHEBI:140916", "name": "sLeX", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10626027", "map_id": "none", "name": "FUT3,5,6,7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10606317", "map_id": "none", "name": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_964746", "map_id": "CHEBI:17925", "name": "Glc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10606314", "map_id": "none", "name": "SLC2A1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q54CM5", "map_id": "Q54CM5", "name": "symA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292814", "map_id": "DDB_G0292814", "name": "symA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Z55", "map_id": "Q54Z55", "name": "SLC2A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277773", "map_id": "DDB_G0277773", "name": "SLC2A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10577719", "map_id": "none", "name": "PGM:Mg2+ isomerise G1P to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29548", "map_id": "CHEBI:16077", "name": "G1P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10577660", "map_id": "none", "name": "PGM:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10615984", "map_id": "none", "name": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_429579", "map_id": "CHEBI:4208", "name": "Man", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6799543", "map_id": "CHEBI:91280", "name": "alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10615981", "map_id": "none", "name": "MAN2C1:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54K67", "map_id": "Q54K67", "name": "manG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287577", "map_id": "DDB_G0287577", "name": "manG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10619249", "map_id": "none", "name": "MANBA hydrolyses GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_8853719", "map_id": "CHEBI:71553", "name": "GlcNAc:Man", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_6799594", "map_id": "CHEBI:4208", "name": "Man", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10619246", "map_id": "Q552S3", "name": "MANBA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "DDB_G0275917", "map_id": "DDB_G0275917", "name": "MANBA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10616013", "map_id": "none", "name": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_6799577", "map_id": "CHEBI:91279", "name": "alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10616010", "map_id": "none", "name": "MAN2B2:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q54YF7", "map_id": "Q54YF7", "name": "manB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278259", "map_id": "DDB_G0278259", "name": "manB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34098", "map_id": "P34098", "name": "manA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292206", "map_id": "DDB_G0292206", "name": "manA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXI8", "map_id": "Q1ZXI8", "name": "manE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278651", "map_id": "DDB_G0278651", "name": "manE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55ER0", "map_id": "Q55ER0", "name": "manC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268994", "map_id": "DDB_G0268994", "name": "manC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YC4", "map_id": "Q54YC4", "name": "manD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278653", "map_id": "DDB_G0278653", "name": "manD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10619244", "map_id": "none", "name": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10619241", "map_id": "none", "name": "MAN2B1:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10593362", "map_id": "none", "name": "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10578646", "map_id": "none", "name": "poly((1,4)-alpha-glucosyl)GYG2 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54L24", "map_id": "Q54L24", "name": "oligo((1,4)-alpha-glycosyl) GYG2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286945", "map_id": "DDB_G0286945", "name": "oligo((1,4)-alpha-glycosyl) GYG2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10593360", "map_id": "none", "name": "GYG2 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10578628", "map_id": "none", "name": "PGYL dimer a form", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q00766", "map_id": "Q00766", "name": "glpV", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281383", "map_id": "DDB_G0281383", "name": "glpV", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10593364", "map_id": "none", "name": "PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10578574", "map_id": "none", "name": "PGYM dimer, b form", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P34114", "map_id": "P34114", "name": "glpD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291123", "map_id": "DDB_G0291123", "name": "glpD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10593354", "map_id": "none", "name": "PGYM b dimer:AMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10625828", "map_id": "none", "name": "GAA hydrolyzes lysosomal glycogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10625815", "map_id": "none", "name": "glycogen-GYG1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_1605745", "map_id": "CHEBI:17925", "name": "Glc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10625819", "map_id": "none", "name": "poly((1,4)-alpha-glucosyl)GYG1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_10625825", "map_id": "none", "name": "GAA (70, 76 kDa)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q55D50", "map_id": "Q55D50", "name": "GAA (204-?)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269790", "map_id": "DDB_G0269790", "name": "GAA (204-?)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578619", "map_id": "none", "name": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10578599", "map_id": "none", "name": "limit dextrin-glycogenin dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10578611", "map_id": "none", "name": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)GYG dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10578616", "map_id": "Q54K94", "name": "AGL", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0287569", "map_id": "DDB_G0287569", "name": "AGL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578651", "map_id": "none", "name": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10578648", "map_id": "none", "name": "poly((1,4)-alpha-glucosyl)GYG dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10578636", "map_id": "none", "name": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10578633", "map_id": "none", "name": "glycogen-glycogenin-2 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10578597", "map_id": "none", "name": "limit dextrin-glycogenin-2 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10602624", "map_id": "none", "name": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602568", "map_id": "none", "name": "oligoGlc-GYG1:GYS1-b tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55GH4", "map_id": "Q55GH4", "name": "phospho-glcS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267674", "map_id": "DDB_G0267674", "name": "phospho-glcS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10602621", "map_id": "none", "name": "polyGlc-GYG1:GYS1-b tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10602596", "map_id": "none", "name": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602591", "map_id": "none", "name": "oligoGlc-GYG2:GYS2-a tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10602593", "map_id": "none", "name": "polyGlc-GYG2:GYS2-a tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10602628", "map_id": "none", "name": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602626", "map_id": "none", "name": "glycogen-GYG1:GYS1-b tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10602581", "map_id": "Q555Q9", "name": "glgB", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0274105", "map_id": "DDB_G0274105", "name": "glgB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10577673", "map_id": "none", "name": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10577670", "map_id": "none", "name": "8xUGP2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54YZ0", "map_id": "Q54YZ0", "name": "ugpB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277879", "map_id": "DDB_G0277879", "name": "ugpB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10602601", "map_id": "none", "name": "Autoglucosylation of GYG2 complexed with GYS2-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602598", "map_id": "none", "name": "GYG2:GYS2-a tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10602571", "map_id": "none", "name": "Autoglucosylation of GYG1 complexed with GYS1-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602566", "map_id": "none", "name": "GYG1:GYS1-b tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10602605", "map_id": "none", "name": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602603", "map_id": "none", "name": "glycogen-GYG2:GYS2-a tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10602614", "map_id": "none", "name": "Autoglucosylation of GYG2 complexed with GYS2-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602609", "map_id": "none", "name": "GYG2:GYS2-b tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10602611", "map_id": "none", "name": "oligoGlc-GYG2:GYS2-b tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10602584", "map_id": "none", "name": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602556", "map_id": "none", "name": "polyGlc-GYG1:GYS1-a tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10602576", "map_id": "none", "name": "glycogen-GYG1:GYS1-a tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10602619", "map_id": "none", "name": "Autoglucosylation of GYG1 complexed with GYS1-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602616", "map_id": "none", "name": "GYG1:GYS1-a tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10602554", "map_id": "none", "name": "oligoGlc-GYG1:GYS1-a tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10626302", "map_id": "none", "name": "PGM1:Mg2+ isomerises G6P to G1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10626297", "map_id": "none", "name": "PGM1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q23919", "map_id": "Q23919", "name": "pgmA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288483", "map_id": "DDB_G0288483", "name": "pgmA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10602559", "map_id": "none", "name": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10624322", "map_id": "none", "name": "PGM2:Mg2+ isomerises dR1P to dR5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6787326", "map_id": "CHEBI:11563", "name": "dR1P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6787328", "map_id": "CHEBI:16132", "name": "dR5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10577654", "map_id": "none", "name": "PGM2:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10578464", "map_id": "none", "name": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29996", "map_id": "CHEBI:16863", "name": "PDG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29732", "map_id": "CHEBI:17363", "name": "RU5P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10578461", "map_id": "none", "name": "PGD dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8TA03", "map_id": "Q8TA03", "name": "gnd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277885", "map_id": "DDB_G0277885", "name": "gnd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10624007", "map_id": "none", "name": "RBKS phosphorylates ribose to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8955853", "map_id": "CHEBI:47013", "name": "D-ribose", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10624004", "map_id": "Q54UQ4", "name": "rbsk", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0280893", "map_id": "DDB_G0280893", "name": "rbsk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578502", "map_id": "none", "name": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29882", "map_id": "CHEBI:15721", "name": "SH7P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29878", "map_id": "CHEBI:16897", "name": "E4P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10578499", "map_id": "none", "name": "TALDO1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54UP4", "map_id": "Q54UP4", "name": "tal", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280909", "map_id": "DDB_G0280909", "name": "tal", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10587241", "map_id": "none", "name": "xylulose 5-phosphate <=> D-ribulose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29790", "map_id": "CHEBI:57737", "name": "XY5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10578481", "map_id": "none", "name": "RPE:Fe2+ dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54YE7", "map_id": "Q54YE7", "name": "rpe", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278275", "map_id": "DDB_G0278275", "name": "rpe", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10582811", "map_id": "none", "name": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_110644", "map_id": "CHEBI:16284", "name": "dATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10580455", "map_id": "none", "name": "PRPS1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q75JN8", "map_id": "Q75JN8", "name": "prsB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272246", "map_id": "DDB_G0272246", "name": "prsB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PA9", "map_id": "Q54PA9", "name": "prsA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284669", "map_id": "DDB_G0284669", "name": "prsA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QU9", "map_id": "Q54QU9", "name": "prsC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283627", "map_id": "DDB_G0283627", "name": "prsC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10580462", "map_id": "none", "name": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10580459", "map_id": "none", "name": "PRPS2 dimer, PRPS1L dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10585872", "map_id": "none", "name": "ribose 5-phosphate <=> D-ribulose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10578489", "map_id": "Q551C2", "name": "rpiA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0276711", "map_id": "DDB_G0276711", "name": "rpiA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10612693", "map_id": "none", "name": "PGM2:Mg2+ isomerises R1P to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10578484", "map_id": "none", "name": "RPE dimers isomerise RU5P to XY5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10578454", "map_id": "none", "name": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10578451", "map_id": "Q54CJ3", "name": "pgl", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0292898", "map_id": "DDB_G0292898", "name": "pgl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10587707", "map_id": "none", "name": "eNOS binds NOSIP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10587703", "map_id": "Q55DU4", "name": "nosip", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0270882", "map_id": "DDB_G0270882", "name": "nosip", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10587705", "map_id": "none", "name": "eNOS:NOSIP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q55DU4", "map_id": "Q55DU4", "name": "nosip", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10587771", "map_id": "none", "name": "eNOS:NOSIP translocation from caveolae to intracellular compartments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10587769", "map_id": "none", "name": "eNOS:NOSIP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10578208", "map_id": "none", "name": "Fumarate + H2O <=> (S)-Malate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113588", "map_id": "CHEBI:18012", "name": "FUMA", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10578205", "map_id": "none", "name": "FH tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54VA2", "map_id": "Q54VA2", "name": "fumH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280495", "map_id": "DDB_G0280495", "name": "fumH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578755", "map_id": "none", "name": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70958", "map_id": "CHEBI:57292", "name": "SUCC-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113536", "map_id": "CHEBI:30031", "name": "SUCCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10578752", "map_id": "none", "name": "SUCLG1:SUCLG2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P36967", "map_id": "P36967", "name": "scsA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289325", "map_id": "DDB_G0289325", "name": "scsA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q869S7", "map_id": "Q869S7", "name": "scsB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274449", "map_id": "DDB_G0274449", "name": "scsB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578180", "map_id": "none", "name": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_29938", "map_id": "CHEBI:151", "name": "ISCIT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10578177", "map_id": "none", "name": "IDH3 complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q55BI2", "map_id": "Q55BI2", "name": "idhA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271344", "map_id": "DDB_G0271344", "name": "idhA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54B68", "map_id": "Q54B68", "name": "idhB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293872", "map_id": "DDB_G0293872", "name": "idhB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10593319", "map_id": "none", "name": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5462", "compartment_display": "mitochondrion" }, { "id": "species_10593316", "map_id": "none", "name": "NNT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q55F30", "map_id": "Q55F30", "name": "NNT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269046", "map_id": "DDB_G0269046", "name": "NNT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10624580", "map_id": "none", "name": "FAHD1:Zn2+ dimer hydrolyses OA to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10624577", "map_id": "none", "name": "FAHD1:Mg2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q86I22", "map_id": "Q86I22", "name": "fahd1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275071", "map_id": "DDB_G0275071", "name": "fahd1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10593321", "map_id": "none", "name": "isocitrate <=> citrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_29654", "map_id": "CHEBI:30769", "name": "CIT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10578185", "map_id": "Q54XS2", "name": "aco2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0278779", "map_id": "DDB_G0278779", "name": "aco2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578537", "map_id": "none", "name": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10578297", "map_id": "none", "name": "lipo-aKGDH", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:17460", "map_id": "CHEBI:17460", "name": "CHEBI:17460", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q869Y7", "map_id": "Q869Y7", "name": "odhB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275029", "map_id": "DDB_G0275029", "name": "odhB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JE4", "map_id": "Q54JE4", "name": "ogdh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288127", "map_id": "DDB_G0288127", "name": "ogdh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8878387", "map_id": "CHEBI:58937", "name": "ThDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10578252", "map_id": "none", "name": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10578249", "map_id": "none", "name": "SUCLA2:SUCLG1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q55AI5", "map_id": "Q55AI5", "name": "scsC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271842", "map_id": "DDB_G0271842", "name": "scsC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578198", "map_id": "none", "name": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113559", "map_id": "CHEBI:15351", "name": "Ac-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10578195", "map_id": "none", "name": "CS dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q553V1", "map_id": "Q553V1", "name": "cs", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275311", "map_id": "DDB_G0275311", "name": "cs", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10624629", "map_id": "none", "name": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10624626", "map_id": "none", "name": "ME3:Mg2+ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q6TU48", "map_id": "Q6TU48", "name": "malA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272524", "map_id": "DDB_G0272524", "name": "malA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578237", "map_id": "none", "name": "Succinate <=> Fumarate (with FAD redox reaction on enzyme)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10578234", "map_id": "none", "name": "SDH complex (ox.)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q8T2T5", "map_id": "Q8T2T5", "name": "sdhC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275115", "map_id": "DDB_G0275115", "name": "sdhC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U3X4", "map_id": "Q9U3X4", "name": "sdhA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280535", "map_id": "DDB_G0280535", "name": "sdhA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YN1", "map_id": "Q54YN1", "name": "sdhD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278157", "map_id": "DDB_G0278157", "name": "sdhD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CC2", "map_id": "Q55CC2", "name": "sdhB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270120", "map_id": "DDB_G0270120", "name": "sdhB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10624605", "map_id": "none", "name": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10624602", "map_id": "none", "name": "ME2:Mg2+ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10624594", "map_id": "none", "name": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10624591", "map_id": "none", "name": "ME1:Mg2+ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10612481", "map_id": "none", "name": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5694130", "map_id": "CHEBI:15694", "name": "(R)-S-LGSH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29708", "map_id": "CHEBI:422", "name": "LACT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10612478", "map_id": "none", "name": "HAGH-2:2xZn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54MR1", "map_id": "Q54MR1", "name": "hagh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285717", "map_id": "DDB_G0285717", "name": "hagh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578535", "map_id": "none", "name": "lipo-PDH decarboxylates PYR to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10578532", "map_id": "none", "name": "lipo-PDH", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q86AD5", "map_id": "Q86AD5", "name": "pdhX", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271564", "map_id": "DDB_G0271564", "name": "pdhX", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54C70", "map_id": "Q54C70", "name": "pdhA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292994", "map_id": "DDB_G0292994", "name": "pdhA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86HX0", "map_id": "Q86HX0", "name": "pdhB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276417", "map_id": "DDB_G0276417", "name": "pdhB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P36413", "map_id": "P36413", "name": "pdhC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277847", "map_id": "DDB_G0277847", "name": "pdhC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10624632", "map_id": "none", "name": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9012375", "map_id": "CHEBI:15361", "name": "PYR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10604611", "map_id": "Q01501", "name": "porA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "DDB_G0271848", "map_id": "DDB_G0271848", "name": "porA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10594272", "map_id": "none", "name": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_880013", "map_id": "CHEBI:32797", "name": "2HG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10594269", "map_id": "Q55GI5", "name": "l2hgdh", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0267656", "map_id": "DDB_G0267656", "name": "l2hgdh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10594262", "map_id": "none", "name": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_879997", "map_id": "CHEBI:32796", "name": "2HG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10594259", "map_id": "Q55E52", "name": "D2HGDH", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0270500", "map_id": "DDB_G0270500", "name": "D2HGDH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_880069", "map_id": "CHEBI:27638", "name": "Co2+", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_880067", "map_id": "CHEBI:29105", "name": "Zn2+", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113527", "map_id": "CHEBI:29035", "name": "Mn2+", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10594264", "map_id": "none", "name": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_880041", "map_id": "CHEBI:16724", "name": "HBUT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_880046", "map_id": "CHEBI:57706", "name": "SUCCSA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10594251", "map_id": "Q54GJ7", "name": "adhfe1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0290111", "map_id": "DDB_G0290111", "name": "adhfe1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10597540", "map_id": "none", "name": "Frataxin binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113531", "map_id": "CHEBI:29033", "name": "Fe2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10597538", "map_id": "none", "name": "FXN:ISD11:NFS1:ISCU", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54C45", "map_id": "Q54C45", "name": "fxn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293246", "map_id": "DDB_G0293246", "name": "fxn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54X04", "map_id": "Q54X04", "name": "nfs1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279287", "map_id": "DDB_G0279287", "name": "nfs1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RP2", "map_id": "Q54RP2", "name": "ISCU-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283003", "map_id": "DDB_G0283003", "name": "ISCU-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FN9", "map_id": "Q54FN9", "name": "lyrm4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290725", "map_id": "DDB_G0290725", "name": "lyrm4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10597511", "map_id": "none", "name": "2 Iron:FXN:NFS1:ISD11:ISCU", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10600913", "map_id": "none", "name": "FDXR transfers electrons to FDX1,2 (FDX1L)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10597532", "map_id": "none", "name": "FDX1,FDX2 (oxidized)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:33737", "map_id": "CHEBI:33737", "name": "CHEBI:33737", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GW1", "map_id": "Q55GW1", "name": "FDX2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267486", "map_id": "DDB_G0267486", "name": "FDX2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10600909", "map_id": "none", "name": "FDXR:FADH2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54KG7", "map_id": "Q54KG7", "name": "fdxr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287353", "map_id": "DDB_G0287353", "name": "fdxr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10600911", "map_id": "none", "name": "FDXR:FAD", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10597524", "map_id": "none", "name": "FDX1,FDX2 (reduced)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:33738", "map_id": "CHEBI:33738", "name": "CHEBI:33738", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10600915", "map_id": "none", "name": "NADPH transfers electrons to FDXR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10622794", "map_id": "none", "name": "Formation of 4Fe-4S cluster on ISCA1:ISCA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10622773", "map_id": "none", "name": "GLRX5:2Fe-2S", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q555C8", "map_id": "Q555C8", "name": "grx5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274657", "map_id": "DDB_G0274657", "name": "grx5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:33739", "map_id": "CHEBI:33739", "name": "CHEBI:33739", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10622785", "map_id": "none", "name": "ISCA1:ISCA2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54VS1", "map_id": "Q54VS1", "name": "isca1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280173", "map_id": "DDB_G0280173", "name": "isca1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54P40", "map_id": "Q54P40", "name": "isca2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284809", "map_id": "DDB_G0284809", "name": "isca2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10622771", "map_id": "Q555C8", "name": "grx5", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10622787", "map_id": "none", "name": "ISCA1:ISCA2:4Fe-4S", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:49883", "map_id": "CHEBI:49883", "name": "CHEBI:49883", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10622792", "map_id": "Q54UQ6", "name": "HSCB", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0280889", "map_id": "DDB_G0280889", "name": "HSCB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10597535", "map_id": "none", "name": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_379721", "map_id": "CHEBI:35235", "name": "L-Cys", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10597526", "map_id": "none", "name": "FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_379697", "map_id": "CHEBI:57972", "name": "L-Ala", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10584066", "map_id": "none", "name": "AMP binds to gamma subunit of AMP kinase heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10584060", "map_id": "none", "name": "AMPK heterotrimer (inactive)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10584064", "map_id": "none", "name": "AMPK heterotrimer:AMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10593844", "map_id": "none", "name": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_70115", "map_id": "CHEBI:17925", "name": "Glc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10593841", "map_id": "none", "name": "GLUT1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10590676", "map_id": "none", "name": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10590673", "map_id": "none", "name": "PLC beta1,2,3:G-alpha(q):GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10592344", "map_id": "none", "name": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_400452", "map_id": "CHEBI:15756", "name": "PALM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10592341", "map_id": "none", "name": "Homologues of 4xPalmC-CD36", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10613507", "map_id": "none", "name": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10613491", "map_id": "none", "name": "DHs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54VG0", "map_id": "Q54VG0", "name": "odhA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280353", "map_id": "DDB_G0280353", "name": "odhA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FN7", "map_id": "Q55FN7", "name": "bkdB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268020", "map_id": "DDB_G0268020", "name": "bkdB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54M22", "map_id": "Q54M22", "name": "bkdA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286335", "map_id": "DDB_G0286335", "name": "bkdA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TR7", "map_id": "Q54TR7", "name": "bkdC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281797", "map_id": "DDB_G0281797", "name": "bkdC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10611517", "map_id": "Q54JV8", "name": "gcvH1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10613499", "map_id": "none", "name": "lipoylated DHs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10613504", "map_id": "Q54KY1", "name": "LIPT1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0287107", "map_id": "DDB_G0287107", "name": "LIPT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10590402", "map_id": "none", "name": "glycine + O2 => glyoxylate + H2O2 + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_193446", "map_id": "CHEBI:57305", "name": "Gly", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389678", "map_id": "CHEBI:16891", "name": "glyoxylate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389843", "map_id": "CHEBI:28938", "name": "NH4+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10590399", "map_id": "none", "name": "DAO dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "Q556W1", "map_id": "Q556W1", "name": "ddo-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273291", "map_id": "DDB_G0273291", "name": "ddo-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10613525", "map_id": "none", "name": "LIPT2 transfers octanoyl group to GCSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10613514", "map_id": "none", "name": "octanoyl:NDUFAB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "CHEBI:25650", "map_id": "CHEBI:25650", "name": "CHEBI:25650", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54E22", "map_id": "Q54E22", "name": "phospho-ndufab1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291866", "map_id": "DDB_G0291866", "name": "phospho-ndufab1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10613517", "map_id": "Q54JV8", "name": "gcvH1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10613512", "map_id": "Q54E22", "name": "ndufab1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10613522", "map_id": "Q553T7", "name": "LIPT2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0275417", "map_id": "DDB_G0275417", "name": "LIPT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10590342", "map_id": "none", "name": "glyoxylate + alanine => glycine + pyruvate [peroxisome]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389664", "map_id": "CHEBI:57972", "name": "L-Ala", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_389680", "map_id": "CHEBI:15361", "name": "PYR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10590339", "map_id": "none", "name": "AGXT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "Q54GT6", "map_id": "Q54GT6", "name": "agxt", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289923", "map_id": "DDB_G0289923", "name": "agxt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10590422", "map_id": "none", "name": "HAO1 tetramer oxidizes glycolate to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389822", "map_id": "CHEBI:29805", "name": "glycolate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10590419", "map_id": "none", "name": "HAO1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "Q54E41", "map_id": "Q54E41", "name": "haox", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291814", "map_id": "DDB_G0291814", "name": "haox", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10590425", "map_id": "none", "name": "Conversion of glyoxylate to oxalate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389819", "map_id": "CHEBI:16995", "name": "OX", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10612523", "map_id": "none", "name": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6784241", "map_id": "CHEBI:27391", "name": "1-pyrroline-3-hydroxy-5-carboxylate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10612520", "map_id": "none", "name": "PRODH2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q86H28", "map_id": "Q86H28", "name": "prodh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10590410", "map_id": "none", "name": "glyoxylate + NADPH + H+ => glycolate + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_10590407", "map_id": "Q54DP1", "name": "tkrA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "DDB_G0292104", "map_id": "DDB_G0292104", "name": "tkrA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617423", "map_id": "none", "name": "DDO oxidizes D-Asp to OA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_6810061", "map_id": "CHEBI:17364", "name": "D-Asp", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6810070", "map_id": "CHEBI:30744", "name": "OA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10617420", "map_id": "none", "name": "DDO:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10612526", "map_id": "none", "name": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6784236", "map_id": "CHEBI:32812", "name": "4-OH-L-Glu", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_6784229", "map_id": "CHEBI:17742", "name": "HOG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10600929", "map_id": "none", "name": "SeMet is converted to AdoSeMet by MAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5357707", "map_id": "CHEBI:30021", "name": "SeMet", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5357652", "map_id": "CHEBI:9066", "name": "AdoSeMet", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10585496", "map_id": "none", "name": "MAT1A multimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54F07", "map_id": "Q54F07", "name": "metK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291179", "map_id": "DDB_G0291179", "name": "metK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10624111", "map_id": "none", "name": "SEPHS2 phosphorylates H2Se to form SELP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5357660", "map_id": "CHEBI:16503", "name": "H2Se", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8959518", "map_id": "CHEBI:16144", "name": "SELP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10624108", "map_id": "Q94497", "name": "selD", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0282367", "map_id": "DDB_G0282367", "name": "selD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10595831", "map_id": "none", "name": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_977329", "map_id": "CHEBI:30933", "name": "3POPA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_936706", "map_id": "CHEBI:15811", "name": "O-P-Ser", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10595828", "map_id": "none", "name": "PXLP-K200-PSAT1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55CQ6", "map_id": "Q55CQ6", "name": "serC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269950", "map_id": "DDB_G0269950", "name": "serC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625019", "map_id": "none", "name": "PXLP-K56-SRR dimer deaminates D-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_376186", "map_id": "CHEBI:16523", "name": "D-Ser", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10625016", "map_id": "none", "name": "PXLP-K56-SRR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54HH2", "map_id": "Q54HH2", "name": "srr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289463", "map_id": "DDB_G0289463", "name": "srr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625800", "map_id": "none", "name": "PXLP-K56-SRR dimer deaminates L-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10625022", "map_id": "none", "name": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10595820", "map_id": "none", "name": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10595817", "map_id": "none", "name": "PSPH:Mg2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54ES3", "map_id": "Q54ES3", "name": "serB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291368", "map_id": "DDB_G0291368", "name": "serB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622893", "map_id": "none", "name": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8932979", "map_id": "CHEBI:33384", "name": "L-Ser", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10622882", "map_id": "Q54UF8", "name": "serinc", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0281099", "map_id": "DDB_G0281099", "name": "serinc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10585521", "map_id": "none", "name": "AHCY:NAD+ tetramer hydrolyses AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10585518", "map_id": "none", "name": "AHCY:NAD+ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P10819", "map_id": "P10819", "name": "sahA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267418", "map_id": "DDB_G0267418", "name": "sahA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598480", "map_id": "none", "name": "PXLP-K212-CTH cleaves L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1614518", "map_id": "CHEBI:17482", "name": "L-Cystathionine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10598454", "map_id": "none", "name": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10598451", "map_id": "none", "name": "PXLP-CBS tetramers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P46794", "map_id": "P46794", "name": "cysB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267386", "map_id": "DDB_G0267386", "name": "cysB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10585499", "map_id": "none", "name": "MAT1A multimers transfer Ado from ATP to L-Met", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_174390", "map_id": "CHEBI:57844", "name": "L-Met", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10585483", "map_id": "none", "name": "MTR transfers CH3 from MeCbl to HCYS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10585476", "map_id": "none", "name": "MTRR:MTR(MeCbl)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54P92", "map_id": "Q54P92", "name": "mtr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284699", "map_id": "DDB_G0284699", "name": "mtr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28115", "map_id": "CHEBI:28115", "name": "CHEBI:28115", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55G48", "map_id": "Q55G48", "name": "MTRR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267824", "map_id": "DDB_G0267824", "name": "MTRR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10585480", "map_id": "none", "name": "MTRR:MTR(cob(I)alamin)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_3159260", "map_id": "CHEBI:15982", "name": "cob(I)alamin", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10597296", "map_id": "none", "name": "Methylthio-ribose-P = Methylthio-ribulose-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1237165", "map_id": "CHEBI:58533", "name": "MTRIBP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1237107", "map_id": "CHEBI:58548", "name": "MTRIBUP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10597293", "map_id": "Q54R90", "name": "MRI1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0283309", "map_id": "DDB_G0283309", "name": "MRI1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10597316", "map_id": "none", "name": "Acireductone is created", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1237176", "map_id": "CHEBI:58828", "name": "2,3-DMPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1237155", "map_id": "CHEBI:58795", "name": "Acireductone", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10597313", "map_id": "none", "name": "E1:Mg++", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55FM6", "map_id": "Q55FM6", "name": "enoph1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268036", "map_id": "DDB_G0268036", "name": "enoph1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10597306", "map_id": "none", "name": "Acireductone is oxidized to MOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1237122", "map_id": "CHEBI:16723", "name": "4MTOBUTA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10597303", "map_id": "none", "name": "ARD:Fe++", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54ER6", "map_id": "Q54ER6", "name": "adi1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291376", "map_id": "DDB_G0291376", "name": "adi1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10577831", "map_id": "none", "name": "PXLP-K314-GPT transaminates L-Ala to form PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29432", "map_id": "CHEBI:57972", "name": "L-Ala", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10577828", "map_id": "none", "name": "PXLP-K314-GPT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54MJ7", "map_id": "Q54MJ7", "name": "gpt", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285899", "map_id": "DDB_G0285899", "name": "gpt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10593878", "map_id": "none", "name": "PXLP-K341-GPT2 transaminates PYR to form L-Ala", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10593875", "map_id": "none", "name": "PXLP-K341-GPT2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10588674", "map_id": "none", "name": "Tyrosine is hydroxylated to dopa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29506", "map_id": "CHEBI:58315", "name": "L-Tyr", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_209849", "map_id": "CHEBI:15765", "name": "L-Dopa", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10588671", "map_id": "none", "name": "TH:Fe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10611411", "map_id": "none", "name": "DUOX1,2 reduce O2 to H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_351627", "map_id": "CHEBI:16474", "name": "NADPH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_351628", "map_id": "CHEBI:18009", "name": "NADP+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10611408", "map_id": "none", "name": "DUOX1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10589347", "map_id": "none", "name": "Iodide is organified", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_209818", "map_id": "CHEBI:16382", "name": "I-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_351630", "map_id": "CHEBI:17606", "name": "I2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10588619", "map_id": "Q6TMK4", "name": "poxA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0277275", "map_id": "DDB_G0277275", "name": "poxA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10588692", "map_id": "none", "name": "DIT and MIT combine to form triiodothyronine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_352329", "map_id": "CHEBI:15768", "name": "DIT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_351639", "map_id": "CHEBI:27847", "name": "MIT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_352331", "map_id": "CHEBI:28774", "name": "T3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_352036", "map_id": "CHEBI:57972", "name": "L-Ala", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10588694", "map_id": "none", "name": "Tyrosine is diiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_352030", "map_id": "CHEBI:58315", "name": "L-Tyr", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10589345", "map_id": "none", "name": "Thyroxine is deiodinated to reverse triiodothyronine (RT3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_209937", "map_id": "CHEBI:18332", "name": "T4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_209785", "map_id": "CHEBI:16382", "name": "I-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_176667", "map_id": "CHEBI:28774", "name": "T3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10589342", "map_id": "Q552Y2", "name": "dio3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0275741", "map_id": "DDB_G0275741", "name": "dio3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10588614", "map_id": "none", "name": "Thyroxine is deiodinated to triiodothyronine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10588611", "map_id": "none", "name": "DIO dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q552Y2", "map_id": "Q552Y2", "name": "dio3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10588685", "map_id": "none", "name": "Two DITs combine to form thyroxine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_352326", "map_id": "CHEBI:18332", "name": "T4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10588622", "map_id": "none", "name": "Tyrosine is monoiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_622410", "map_id": "CHEBI:43451", "name": "HI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10612514", "map_id": "none", "name": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_35305", "map_id": "CHEBI:17388", "name": "1PYR-5COOH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_113538", "map_id": "CHEBI:60039", "name": "L-Pro", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10612511", "map_id": "none", "name": "PYCRL decamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54IL7", "map_id": "Q54IL7", "name": "pycr1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288671", "map_id": "DDB_G0288671", "name": "pycr1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10577861", "map_id": "none", "name": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_517496", "map_id": "none", "name": "NAD(P)H", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_113561", "map_id": "CHEBI:28938", "name": "NH4+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_517495", "map_id": "none", "name": "NAD(P)+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10577858", "map_id": "none", "name": "GLUD hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54KB7", "map_id": "Q54KB7", "name": "gluD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287469", "map_id": "DDB_G0287469", "name": "gluD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10594292", "map_id": "none", "name": "glutamine + pyruvate => 2-oxoglutaramate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_893598", "map_id": "CHEBI:30882", "name": "2OGA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10594283", "map_id": "none", "name": "PXLP-KYAT1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54KM6", "map_id": "Q54KM6", "name": "ccbl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287269", "map_id": "DDB_G0287269", "name": "ccbl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10577927", "map_id": "none", "name": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10577924", "map_id": "none", "name": "PYCR1 decamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10577929", "map_id": "none", "name": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_31339", "map_id": "CHEBI:17232", "name": "L-Glu5S", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113585", "map_id": "CHEBI:15729", "name": "L-Orn", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10577914", "map_id": "none", "name": "OAT hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54JP5", "map_id": "Q54JP5", "name": "oatA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287913", "map_id": "DDB_G0287913", "name": "oatA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10612507", "map_id": "none", "name": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10612504", "map_id": "none", "name": "PYCR2 decamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10577884", "map_id": "none", "name": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10578387", "map_id": "none", "name": "homogentisate + O2 => maleylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30337", "map_id": "CHEBI:16169", "name": "HGTA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_31135", "map_id": "CHEBI:17105", "name": "4MAA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10578384", "map_id": "none", "name": "HGD hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54QI4", "map_id": "Q54QI4", "name": "hgd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283765", "map_id": "DDB_G0283765", "name": "hgd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578407", "map_id": "none", "name": "fumarylacetoacetate => fumarate + acetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_31175", "map_id": "CHEBI:18034", "name": "4FAA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29666", "map_id": "CHEBI:13705", "name": "ACA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29586", "map_id": "CHEBI:37154", "name": "FUMA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10578404", "map_id": "none", "name": "FAH dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q1ZXQ1", "map_id": "Q1ZXQ1", "name": "fah", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271094", "map_id": "DDB_G0271094", "name": "fah", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578358", "map_id": "none", "name": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_31365", "map_id": "CHEBI:15999", "name": "HPPYRA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10578355", "map_id": "none", "name": "TAT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54K95", "map_id": "Q54K95", "name": "tat", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287515", "map_id": "DDB_G0287515", "name": "tat", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578377", "map_id": "none", "name": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10578374", "map_id": "none", "name": "HPD:AscH-:Fe2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q76NV5", "map_id": "Q76NV5", "name": "hpd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277511", "map_id": "DDB_G0277511", "name": "hpd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q557J8", "map_id": "Q557J8", "name": "hpdl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273429", "map_id": "DDB_G0273429", "name": "hpdl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_198816", "map_id": "CHEBI:38290", "name": "AscH-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10578397", "map_id": "none", "name": "maleylacetoacetate => fumarylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10578394", "map_id": "none", "name": "GSTZ1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10600401", "map_id": "none", "name": "IL4I1:FAD oxidises L-Phe to kPPV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_2160466", "map_id": "CHEBI:18005", "name": "kPPV", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10600398", "map_id": "none", "name": "IL4I1:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q54EW2", "map_id": "Q54EW2", "name": "IL4I1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293662", "map_id": "DDB_G0293662", "name": "IL4I1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55B17", "map_id": "Q55B17", "name": "IL4I1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BE7", "map_id": "Q54BE7", "name": "IL4I1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55B19", "map_id": "Q55B19", "name": "IL4I1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578320", "map_id": "none", "name": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29502", "map_id": "CHEBI:58095", "name": "L-Phe", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10578317", "map_id": "none", "name": "PAH:Fe2+ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10578347", "map_id": "none", "name": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_71129", "map_id": "CHEBI:20680", "name": "qDHB", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10578344", "map_id": "none", "name": "PCBD1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54XF6", "map_id": "Q54XF6", "name": "PCBD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278993", "map_id": "DDB_G0278993", "name": "PCBD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RY8", "map_id": "Q54RY8", "name": "pcbd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282831", "map_id": "DDB_G0282831", "name": "pcbd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578330", "map_id": "none", "name": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10578327", "map_id": "none", "name": "QDPR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86A17", "map_id": "Q86A17", "name": "qdpr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272684", "map_id": "DDB_G0272684", "name": "qdpr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10594286", "map_id": "none", "name": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_893599", "map_id": "CHEBI:29750", "name": "3IN-PYRA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10577841", "map_id": "none", "name": "glutamate + acetyl CoA => N-acetyl glutamate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_30471", "map_id": "CHEBI:17533", "name": "NAcGlu", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10577838", "map_id": "Q54M18", "name": "argC", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0286257", "map_id": "DDB_G0286257", "name": "argC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_374064", "map_id": "CHEBI:32682", "name": "L-Arg", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10577906", "map_id": "none", "name": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_113567", "map_id": "CHEBI:16349", "name": "L-Cit", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_29498", "map_id": "CHEBI:15729", "name": "L-Orn", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10577903", "map_id": "none", "name": "Homologues of SLC25A15", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q54FE6", "map_id": "Q54FE6", "name": "mcfS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290913", "map_id": "DDB_G0290913", "name": "mcfS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55E85", "map_id": "Q55E85", "name": "mcfD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269352", "map_id": "DDB_G0269352", "name": "mcfD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86HN8", "map_id": "Q86HN8", "name": "mcfY", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274501", "map_id": "DDB_G0274501", "name": "mcfY", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10593352", "map_id": "none", "name": "arginine + H2O => ornithine + urea [ARG2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_374061", "map_id": "CHEBI:16199", "name": "Urea", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10593349", "map_id": "none", "name": "ARG2 trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54HV8", "map_id": "Q54HV8", "name": "ARG1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289195", "map_id": "DDB_G0289195", "name": "ARG1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10577851", "map_id": "none", "name": "arginine + H2O => ornithine + urea [ARG1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29514", "map_id": "CHEBI:16199", "name": "Urea", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10577848", "map_id": "none", "name": "ARG1 trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10577872", "map_id": "none", "name": "GOT2 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10613589", "map_id": "none", "name": "ASPG hydrolyses L-Asn to L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29642", "map_id": "CHEBI:58048", "name": "L-Asn", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10613586", "map_id": "Q86I82", "name": "aspA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0271924", "map_id": "DDB_G0271924", "name": "aspA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10577882", "map_id": "none", "name": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10577879", "map_id": "none", "name": "ASNS dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54MB4", "map_id": "Q54MB4", "name": "asns", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286059", "map_id": "DDB_G0286059", "name": "asns", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10623961", "map_id": "none", "name": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_8954466", "map_id": "CHEBI:21547", "name": "NAA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10623958", "map_id": "none", "name": "Homologues of NAT8L", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54IG0", "map_id": "Q54IG0", "name": "NAT8L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293514", "map_id": "DDB_G0293514", "name": "NAT8L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BP5", "map_id": "Q54BP5", "name": "NAT8L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578417", "map_id": "none", "name": "TDO tetramer dioxygenates L-Trp to NFK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_33179", "map_id": "CHEBI:18377", "name": "NFK", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10578414", "map_id": "none", "name": "TDO2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55DB4", "map_id": "Q55DB4", "name": "tdo", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269714", "map_id": "DDB_G0269714", "name": "tdo", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10594289", "map_id": "none", "name": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29970", "map_id": "CHEBI:16946", "name": "L-KYN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_893615", "map_id": "CHEBI:17442", "name": "AP-DOBu", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8939576", "map_id": "none", "name": "I3LACT, I3PROPA", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:55528", "map_id": "CHEBI:55528", "name": "CHEBI:55528", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:43580", "map_id": "CHEBI:43580", "name": "CHEBI:43580", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10594275", "map_id": "none", "name": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_893607", "map_id": "CHEBI:16946", "name": "L-KYN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_893617", "map_id": "CHEBI:17442", "name": "APDBA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10578160", "map_id": "none", "name": "AADAT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54K00", "map_id": "Q54K00", "name": "PXLP-AADAT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287711", "map_id": "DDB_G0287711", "name": "PXLP-AADAT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578436", "map_id": "none", "name": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_34351", "map_id": "CHEBI:17380", "name": "3HKYN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_30487", "map_id": "CHEBI:15793", "name": "3HAA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10578433", "map_id": "none", "name": "KYNU dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54Q04", "map_id": "Q54Q04", "name": "kynu", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284203", "map_id": "DDB_G0284203", "name": "kynu", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578425", "map_id": "none", "name": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10578422", "map_id": "Q54RE8", "name": "kmo", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0283173", "map_id": "DDB_G0283173", "name": "kmo", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10620687", "map_id": "none", "name": "SLC36A4 transports L-Trp from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_352006", "map_id": "CHEBI:57912", "name": "L-Trp", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10620684", "map_id": "Q54CB3", "name": "SLC36A4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0293074", "map_id": "DDB_G0293074", "name": "SLC36A4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578446", "map_id": "none", "name": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_36027", "map_id": "CHEBI:29044", "name": "ACS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10578443", "map_id": "none", "name": "HAAO", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54S02", "map_id": "Q54S02", "name": "haao", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282743", "map_id": "DDB_G0282743", "name": "haao", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10606628", "map_id": "none", "name": "Tyrosinase oxidises tyrosine to dopaquinone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane" }, { "id": "species_5668573", "map_id": "CHEBI:29191", "name": "hydroxyl", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_5668567", "map_id": "CHEBI:58315", "name": "L-Tyr", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_5668577", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_5662695", "map_id": "CHEBI:16852", "name": "L-Dopaquinone", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_10606620", "map_id": "none", "name": "TYR:2xCu2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane", "complex": "true" }, { "id": "Q54QT0", "map_id": "Q54QT0", "name": "TYRP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283653", "map_id": "DDB_G0283653", "name": "TYRP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QT1", "map_id": "Q54QT1", "name": "TYRP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10606626", "map_id": "Q7KWK4", "name": "SLC45A2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane", "complex": "false" }, { "id": "DDB_G0276801", "map_id": "DDB_G0276801", "name": "SLC45A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10606612", "map_id": "none", "name": "Dopachrome is transformed to DHICA by DCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen" }, { "id": "species_5662665", "map_id": "CHEBI:49108", "name": "Dopachrome", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_5662670", "map_id": "CHEBI:2003", "name": "DHICA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_10606609", "map_id": "none", "name": "DCT:2xZn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane", "complex": "true" }, { "id": "reaction_10606631", "map_id": "none", "name": "Dopa is oxidized to dopaquinone by TYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen" }, { "id": "species_5668568", "map_id": "CHEBI:15765", "name": "L-Dopa", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_5668566", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_5668574", "map_id": "CHEBI:15377", "name": "H2O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "reaction_10606633", "map_id": "none", "name": "DHI and DHICA polymerise forming eumelanin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen" }, { "id": "species_5662708", "map_id": "none", "name": "DHI, DHICA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "true" }, { "id": "CHEBI:27404", "map_id": "CHEBI:27404", "name": "CHEBI:27404", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5662678", "map_id": "none", "name": "Eumelanin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "true" }, { "id": "reaction_10622761", "map_id": "none", "name": "TYRP1 oxidises DHICA to IQCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane" }, { "id": "species_8878586", "map_id": "CHEBI:81394", "name": "IQCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5668572", "compartment_display": "melanosome lumen", "complex": "false" }, { "id": "species_10622758", "map_id": "none", "name": "Homologues of TYRP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane", "complex": "true" }, { "id": "reaction_10578017", "map_id": "none", "name": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70772", "map_id": "CHEBI:15488", "name": "bMC-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_70784", "map_id": "CHEBI:15467", "name": "bHMG-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10578014", "map_id": "none", "name": "AUH hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54HG7", "map_id": "Q54HG7", "name": "auh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289471", "map_id": "DDB_G0289471", "name": "auh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10593920", "map_id": "none", "name": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70836", "map_id": "CHEBI:15476", "name": "2MACA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_70829", "map_id": "CHEBI:15449", "name": "aMbHBUT-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10578034", "map_id": "none", "name": "HSD17B10 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q86JE3", "map_id": "Q86JE3", "name": "HSD17B10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272128", "map_id": "DDB_G0272128", "name": "HSD17B10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10593922", "map_id": "none", "name": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_30004", "map_id": "CHEBI:16256", "name": "2M3OPROA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_573404", "map_id": "CHEBI:11805", "name": "bHIBA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10578082", "map_id": "none", "name": "HIBADH tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54CX6", "map_id": "Q54CX6", "name": "hibA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292566", "map_id": "DDB_G0292566", "name": "hibA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10577989", "map_id": "none", "name": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_508182", "map_id": "none", "name": "Leu, Ile, Val", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_29588", "map_id": "CHEBI:57427", "name": "L-Leu", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "CHEBI:58045", "map_id": "CHEBI:58045", "name": "CHEBI:58045", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:57762", "map_id": "CHEBI:57762", "name": "CHEBI:57762", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_508187", "map_id": "none", "name": "KIC,KMVA,KIV", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:28654", "map_id": "CHEBI:28654", "name": "CHEBI:28654", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17865", "map_id": "CHEBI:17865", "name": "CHEBI:17865", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16530", "map_id": "CHEBI:16530", "name": "CHEBI:16530", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10577986", "map_id": "none", "name": "BCAT1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54N47", "map_id": "Q54N47", "name": "bcaA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285509", "map_id": "DDB_G0285509", "name": "bcaA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578057", "map_id": "none", "name": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70851", "map_id": "CHEBI:15479", "name": "ISB-CoA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_70858", "map_id": "CHEBI:27754", "name": "MACR-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10578054", "map_id": "none", "name": "ACAD8 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54IM8", "map_id": "Q54IM8", "name": "acad8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288647", "map_id": "DDB_G0288647", "name": "acad8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578027", "map_id": "none", "name": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70718", "map_id": "CHEBI:15477", "name": "2MBUT-CoA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_70799", "map_id": "CHEBI:15478", "name": "tiglyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10578024", "map_id": "none", "name": "ACADSB tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54RR5", "map_id": "Q54RR5", "name": "acadsb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282967", "map_id": "DDB_G0282967", "name": "acadsb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10577997", "map_id": "none", "name": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_508190", "map_id": "none", "name": "Leu, Ile, Val", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_508181", "map_id": "none", "name": "KIC, KMVA, KIV", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10577994", "map_id": "none", "name": "BCAT2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10578093", "map_id": "none", "name": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70843", "map_id": "CHEBI:15539", "name": "PROP-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10578090", "map_id": "Q54I10", "name": "mmsdh", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0289085", "map_id": "DDB_G0289085", "name": "mmsdh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578067", "map_id": "none", "name": "ECHS1 hydrates methacrylyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_71847", "map_id": "CHEBI:28259", "name": "bHIB-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10578007", "map_id": "none", "name": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70715", "map_id": "CHEBI:15487", "name": "ISV-CoA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_70744", "map_id": "CHEBI:15486", "name": "bMC-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10578004", "map_id": "none", "name": "IVD tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54W88", "map_id": "Q54W88", "name": "ivdA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279827", "map_id": "DDB_G0279827", "name": "ivdA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578075", "map_id": "none", "name": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10578072", "map_id": "Q55GS6", "name": "hibch", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0267536", "map_id": "DDB_G0267536", "name": "hibch", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10577978", "map_id": "none", "name": "BCKDH transfers CoA group from CoA-SH to BCAAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_508261", "map_id": "none", "name": "BCAA-CoAs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10577975", "map_id": "none", "name": "lipo-BCKDH", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10578047", "map_id": "none", "name": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10578044", "map_id": "none", "name": "ACAT1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q86AD9", "map_id": "Q86AD9", "name": "ACAT1(35-427)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271544", "map_id": "DDB_G0271544", "name": "ACAT1(35-427)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10589365", "map_id": "none", "name": "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_353113", "map_id": "CHEBI:15625", "name": "dc-AdoMet", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29610", "map_id": "CHEBI:17148", "name": "Putrescine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10589362", "map_id": "Q9XY92", "name": "spsA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0268630", "map_id": "DDB_G0268630", "name": "spsA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10589355", "map_id": "none", "name": "Spermine => N-acetylated spermine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_353560", "map_id": "CHEBI:15746", "name": "SPN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_353575", "map_id": "CHEBI:17312", "name": "NASPN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10589352", "map_id": "Q54W72", "name": "SAT1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0279851", "map_id": "DDB_G0279851", "name": "SAT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10589357", "map_id": "none", "name": "Spermidine => N-acetylated spermidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_353555", "map_id": "CHEBI:17927", "name": "NASPM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10577946", "map_id": "none", "name": "ornithine => putrescine + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10577943", "map_id": "Q54UF3", "name": "odc", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10589373", "map_id": "none", "name": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10589370", "map_id": "Q8T1E3", "name": "amd1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0275567", "map_id": "DDB_G0275567", "name": "amd1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578163", "map_id": "none", "name": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_508531", "map_id": "CHEBI:17082", "name": "2AMA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_70951", "map_id": "CHEBI:15753", "name": "aKADA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10612802", "map_id": "none", "name": "HYKK phosphorylates 5HLYS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6788606", "map_id": "CHEBI:60175", "name": "5HLYS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5696409", "map_id": "CHEBI:16752", "name": "5PHL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10612799", "map_id": "C7G071", "name": "HYKK", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0295739", "map_id": "DDB_G0295739", "name": "HYKK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10612500", "map_id": "none", "name": "PIPOX oxidises PPCA to P6C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_5693325", "map_id": "CHEBI:30913", "name": "PPCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6783877", "map_id": "CHEBI:58769", "name": "P6C", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10612497", "map_id": "Q54US8", "name": "PIPOX", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "DDB_G0280851", "map_id": "DDB_G0280851", "name": "PIPOX", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10589556", "map_id": "none", "name": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113577", "map_id": "CHEBI:15753", "name": "aKADA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10589553", "map_id": "Q55GE2", "name": "mcfT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0267704", "map_id": "DDB_G0267704", "name": "mcfT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578310", "map_id": "none", "name": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70955", "map_id": "CHEBI:15524", "name": "GL-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_71045", "map_id": "CHEBI:15473", "name": "crotonyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10578307", "map_id": "none", "name": "GCDH tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54R47", "map_id": "Q54R47", "name": "gcdh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283411", "map_id": "DDB_G0283411", "name": "gcdh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578152", "map_id": "none", "name": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113556", "map_id": "CHEBI:17917", "name": "2AMAS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10578149", "map_id": "none", "name": "ALDH7A1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P83401", "map_id": "P83401", "name": "ALDH7A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276821", "map_id": "DDB_G0276821", "name": "ALDH7A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578139", "map_id": "none", "name": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_29444", "map_id": "CHEBI:32551", "name": "L-Lys", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_30176", "map_id": "CHEBI:16927", "name": "SACN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10578136", "map_id": "none", "name": "AASS tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54NG9", "map_id": "Q54NG9", "name": "sdh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285267", "map_id": "DDB_G0285267", "name": "sdh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10611324", "map_id": "none", "name": "CRYM reduces P2C to PPCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_5693311", "map_id": "CHEBI:16187", "name": "P2C", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10611321", "map_id": "Q54CJ8", "name": "CRYM", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "DDB_G0292894", "map_id": "DDB_G0292894", "name": "CRYM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578300", "map_id": "none", "name": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10578142", "map_id": "none", "name": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10578129", "map_id": "none", "name": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30158", "map_id": "CHEBI:18327", "name": "NF-Glu", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_70919", "map_id": "CHEBI:15639", "name": "FITHF", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10578126", "map_id": "none", "name": "FTCD octamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54JL3", "map_id": "Q54JL3", "name": "ftcd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287977", "map_id": "DDB_G0287977", "name": "ftcd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578101", "map_id": "none", "name": "histidine => urocanate + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29612", "map_id": "CHEBI:32513", "name": "L-His", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_30721", "map_id": "CHEBI:30817", "name": "UCA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10578098", "map_id": "Q54JI7", "name": "hal", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0288025", "map_id": "DDB_G0288025", "name": "hal", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578119", "map_id": "none", "name": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_34979", "map_id": "CHEBI:27384", "name": "4I-5PROA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10578116", "map_id": "Q55CY3", "name": "amdhd1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0269854", "map_id": "DDB_G0269854", "name": "amdhd1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622372", "map_id": "none", "name": "CARNMT1 methylates CARN to Anserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6786250", "map_id": "CHEBI:15727", "name": "CARN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8876775", "map_id": "CHEBI:18323", "name": "Anserine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10622369", "map_id": "Q54ST2", "name": "CARNMT1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0282239", "map_id": "DDB_G0282239", "name": "CARNMT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578111", "map_id": "none", "name": "urocanate + H2O => 4-imidazolone-5-propionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10578108", "map_id": "none", "name": "UROC1:NAD+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86AX3", "map_id": "Q86AX3", "name": "uroc1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277727", "map_id": "DDB_G0277727", "name": "uroc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10613621", "map_id": "none", "name": "SLC44A1 transports Cho from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6798162", "map_id": "CHEBI:15354", "name": "Cho", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10613618", "map_id": "none", "name": "Homologues of SLC44A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10613629", "map_id": "none", "name": "CHDH oxidises Cho to BETALD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6798194", "map_id": "CHEBI:15710", "name": "BETALD", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10613626", "map_id": "B0G160", "name": "chdh", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0287229", "map_id": "DDB_G0287229", "name": "chdh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10613612", "map_id": "none", "name": "ALDH7A1 oxidises BETALD to BET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6798202", "map_id": "CHEBI:17750", "name": "BET", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10578147", "map_id": "P83401", "name": "ALDH7A1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10580773", "map_id": "none", "name": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_73871", "map_id": "CHEBI:15345", "name": "ACA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10621991", "map_id": "none", "name": "ACSS3 ligates CoA to CH3COO-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113539", "map_id": "CHEBI:30089", "name": "CH3COO-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10621988", "map_id": "Q554Z5", "name": "aslB", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0274939", "map_id": "DDB_G0274939", "name": "aslB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10580788", "map_id": "none", "name": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_73917", "map_id": "CHEBI:15467", "name": "HMG CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10580785", "map_id": "none", "name": "Homologues of HMGCS2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P54872", "map_id": "P54872", "name": "hgsA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288461", "map_id": "DDB_G0288461", "name": "hgsA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86HL5", "map_id": "Q86HL5", "name": "hgsB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10581175", "map_id": "none", "name": "HMG CoA => acetoacetic acid + acetyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_73909", "map_id": "CHEBI:15344", "name": "ACA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10581172", "map_id": "none", "name": "HMGCL dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54QI7", "map_id": "Q54QI7", "name": "hmgL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283813", "map_id": "DDB_G0283813", "name": "hmgL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10612794", "map_id": "none", "name": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10612791", "map_id": "none", "name": "HMGCLL1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10581165", "map_id": "none", "name": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10581162", "map_id": "none", "name": "OXCT dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54JD9", "map_id": "Q54JD9", "name": "oxct1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288105", "map_id": "DDB_G0288105", "name": "oxct1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10600081", "map_id": "none", "name": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_2046052", "map_id": "CHEBI:63545", "name": "SDA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2046051", "map_id": "CHEBI:63542", "name": "ETA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10600112", "map_id": "none", "name": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_2066767", "map_id": "CHEBI:65139", "name": "delta2-THA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_2066766", "map_id": "CHEBI:65130", "name": "1-3-hydroxy-THA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10600083", "map_id": "none", "name": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_2046057", "map_id": "CHEBI:63541", "name": "DPA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2046065", "map_id": "CHEBI:63543", "name": "TPA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10600114", "map_id": "none", "name": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_2066762", "map_id": "CHEBI:65131", "name": "1-3-oxo-THA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10600116", "map_id": "none", "name": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_2046047", "map_id": "CHEBI:63540", "name": "THA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10590470", "map_id": "none", "name": "ACOX1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10600119", "map_id": "none", "name": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_193514", "map_id": "CHEBI:15346", "name": "CoA-SH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_353123", "map_id": "CHEBI:15351", "name": "Ac-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_2066765", "map_id": "CHEBI:65132", "name": "DHA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10590457", "map_id": "Q86IY4", "name": "ACAA1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "DDB_G0274339", "map_id": "DDB_G0274339", "name": "ACAA1(1-424)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10600093", "map_id": "none", "name": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2046059", "map_id": "CHEBI:63539", "name": "EPA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10600076", "map_id": "none", "name": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2046056", "map_id": "CHEBI:27432", "name": "ALA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2046062", "map_id": "CHEBI:51985", "name": "ALA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10600079", "map_id": "none", "name": "Translocation of tetracosahexaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_2046054", "map_id": "CHEBI:63540", "name": "THA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10578260", "map_id": "none", "name": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_71019", "map_id": "CHEBI:15466", "name": "MEMA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_71009", "map_id": "CHEBI:15465", "name": "L-MM-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10578257", "map_id": "Q553V2", "name": "mcee", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0275181", "map_id": "DDB_G0275181", "name": "mcee", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578278", "map_id": "none", "name": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10578275", "map_id": "none", "name": "6x(Btn-PCCA:PCCB)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q553S7", "map_id": "Q553S7", "name": "pccA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275355", "map_id": "DDB_G0275355", "name": "pccA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T131", "map_id": "Q8T131", "name": "PCCB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276341", "map_id": "DDB_G0276341", "name": "PCCB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10582422", "map_id": "none", "name": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77255", "map_id": "CHEBI:15471", "name": "2-trans-Dodecenoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77252", "map_id": "CHEBI:27668", "name": "(S)-3-Hydroxydodecanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10582424", "map_id": "none", "name": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77313", "map_id": "CHEBI:15473", "name": "Crotonoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77251", "map_id": "CHEBI:15453", "name": "3HB-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10582428", "map_id": "none", "name": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77332", "map_id": "CHEBI:27537", "name": "trans-Oct-2-enoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77330", "map_id": "CHEBI:28632", "name": "(S)-Hydroxyoctanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10582426", "map_id": "none", "name": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77324", "map_id": "CHEBI:28706", "name": "trans-Hex-2-enoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77322", "map_id": "CHEBI:28276", "name": "(S)-Hydroxyhexanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10611862", "map_id": "none", "name": "ACSF2 ligates CoA-SH to MCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5690531", "map_id": "CHEBI:59554", "name": "MCFA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_5690542", "map_id": "CHEBI:61907", "name": "MCFA-CoA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10611859", "map_id": "Q54NV9", "name": "ACSF2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0284963", "map_id": "DDB_G0284963", "name": "ACSF2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10618485", "map_id": "none", "name": "ACBD6 binds LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_164991", "map_id": "CHEBI:33184", "name": "LCFA-CoA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10618481", "map_id": "Q54GC8", "name": "acbd6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0290237", "map_id": "DDB_G0290237", "name": "acbd6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10618483", "map_id": "none", "name": "ACBD6:LCFA-CoA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54GC8", "map_id": "Q54GC8", "name": "acbd6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622907", "map_id": "none", "name": "MCAT transfers Mal from Mal-CoA to NDUFAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_977314", "map_id": "CHEBI:15531", "name": "Malonyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10622896", "map_id": "Q54E22", "name": "phospho-ndufab1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10622899", "map_id": "Q54E22", "name": "phospho-ndufab1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10622904", "map_id": "Q55DQ6", "name": "MCAT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0270558", "map_id": "DDB_G0270558", "name": "MCAT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10610781", "map_id": "none", "name": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5690540", "map_id": "none", "name": "MCFA-CoA, LCFA-CoA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_5690519", "map_id": "none", "name": "MCFA, LCFA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10610778", "map_id": "none", "name": "ACOT2,9, THEM4,5 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54LP9", "map_id": "Q54LP9", "name": "ACOT9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286507", "map_id": "DDB_G0286507", "name": "ACOT9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10610767", "map_id": "none", "name": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5690044", "map_id": "none", "name": "MCFA-CoA, LCFA-CoA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_5690064", "map_id": "none", "name": "MCFA, LCFA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10610764", "map_id": "none", "name": "ACOT13 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "C7G041", "map_id": "C7G041", "name": "ACOT13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0295733", "map_id": "DDB_G0295733", "name": "ACOT13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10618476", "map_id": "none", "name": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_8848288", "map_id": "none", "name": "MCFA-CoA, LCFA-CoA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10618470", "map_id": "Q5FXM5", "name": "acbA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "DDB_G0270658", "map_id": "DDB_G0270658", "name": "acbA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10618474", "map_id": "none", "name": "DBI,ACBD7:MCFA-CoA,LCFA-CoA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "Q5FXM5", "map_id": "Q5FXM5", "name": "acbA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10587345", "map_id": "none", "name": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10587333", "map_id": "none", "name": "Btn-ACACB:2Mn2+ polymer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q54J08", "map_id": "Q54J08", "name": "phospho-accA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10587340", "map_id": "none", "name": "Btn-p-S79-ACACB:2Mn2+ polymer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "species_10587342", "map_id": "none", "name": "AMPK heterotrimer (active)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10581624", "map_id": "none", "name": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10581621", "map_id": "none", "name": "Btn-ACACA:2Mn2+ polymer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10622445", "map_id": "none", "name": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10612737", "map_id": "none", "name": "HAO2 tetramer oxidises 2OH-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_6787810", "map_id": "CHEBI:65101", "name": "2OH-PALM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6787814", "map_id": "CHEBI:86988", "name": "2oxo-PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10612734", "map_id": "none", "name": "HAO2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10590464", "map_id": "none", "name": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_390249", "map_id": "CHEBI:52975", "name": "trans-2,3-dehydrohexacosanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_390248", "map_id": "CHEBI:64972", "name": "3-hydroxyhexacosanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10595810", "map_id": "none", "name": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_977323", "map_id": "CHEBI:15531", "name": "Malonyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10595807", "map_id": "Q54GK8", "name": "MLYCD(40-493)", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "DDB_G0290089", "map_id": "DDB_G0290089", "name": "MLYCD(40-493)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10590473", "map_id": "none", "name": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_390260", "map_id": "CHEBI:52966", "name": "C26:0 CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10617416", "map_id": "none", "name": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_6809801", "map_id": "CHEBI:85939", "name": "3Z-octenoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6809800", "map_id": "CHEBI:27537", "name": "2E-octenoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10617413", "map_id": "none", "name": "ECI2 trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10590493", "map_id": "none", "name": "Peroxisomal uptake of very long-chain fatty acyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_390394", "map_id": "CHEBI:52966", "name": "C26:0 CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10590197", "map_id": "none", "name": "ABCD1 homodimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "Q8T8P3", "map_id": "Q8T8P3", "name": "abcD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10590460", "map_id": "none", "name": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_390241", "map_id": "CHEBI:52977", "name": "3-ketohexacosanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_390246", "map_id": "CHEBI:52974", "name": "tetracosanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10590462", "map_id": "none", "name": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "reaction_10617487", "map_id": "none", "name": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_6810523", "map_id": "CHEBI:37554", "name": "FA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6809360", "map_id": "CHEBI:37240", "name": "3',5'-ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6810530", "map_id": "CHEBI:47983", "name": "acyl-PPANT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10617484", "map_id": "Q54GC2", "name": "NUDT19", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "DDB_G0290277", "map_id": "DDB_G0290277", "name": "NUDT19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10590323", "map_id": "none", "name": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389615", "map_id": "CHEBI:15538", "name": "Phytanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389594", "map_id": "CHEBI:15475", "name": "3S2HPhy-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389583", "map_id": "CHEBI:30031", "name": "SUCCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10590320", "map_id": "none", "name": "PHYH:Fe++", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "Q54SF6", "map_id": "Q54SF6", "name": "PHYH(1-338)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282495", "map_id": "DDB_G0282495", "name": "PHYH(1-338)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10590313", "map_id": "none", "name": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389578", "map_id": "CHEBI:15522", "name": "FOR-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389636", "map_id": "CHEBI:49189", "name": "Pristanal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10590310", "map_id": "none", "name": "HACL1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "Q54DA9", "map_id": "Q54DA9", "name": "hacl1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292402", "map_id": "DDB_G0292402", "name": "hacl1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10590331", "map_id": "none", "name": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_389620", "map_id": "CHEBI:16027", "name": "AMP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389573", "map_id": "CHEBI:30616", "name": "ATP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10590328", "map_id": "Q76P23", "name": "mcfQ", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "false" }, { "id": "DDB_G0272346", "map_id": "DDB_G0272346", "name": "mcfQ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10590301", "map_id": "none", "name": "ALDH3A2-2 oxidizes pristanal to pristanate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_6811612", "map_id": "CHEBI:77268", "name": "pristanate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10590298", "map_id": "none", "name": "ALDH3A2-2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "Q54DG1", "map_id": "Q54DG1", "name": "comG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292270", "map_id": "DDB_G0292270", "name": "comG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10589036", "map_id": "none", "name": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29768", "map_id": "CHEBI:15843", "name": "AA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_266010", "map_id": "CHEBI:15632", "name": "5S-HpETE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10589033", "map_id": "none", "name": "ALOX5:ALOX5AP:LTC4S", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "Q54GA9", "map_id": "Q54GA9", "name": "mgst", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290291", "map_id": "DDB_G0290291", "name": "mgst", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10600427", "map_id": "none", "name": "Arachidonic acid is converted to HXA3/B3 by ALOX12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2162031", "map_id": "none", "name": "HXA3/B3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_8942209", "map_id": "CHEBI:36190", "name": "HXA3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:34784", "map_id": "CHEBI:34784", "name": "CHEBI:34784", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10600435", "map_id": "none", "name": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2142739", "map_id": "CHEBI:34450", "name": "5,6-EET", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10582322", "map_id": "none", "name": "Homologues of CYP2J2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54QD0", "map_id": "Q54QD0", "name": "cyp517A4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283933", "map_id": "DDB_G0283933", "name": "cyp517A4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QD2", "map_id": "Q54QD2", "name": "cyp517A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283929", "map_id": "DDB_G0283929", "name": "cyp517A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXA1", "map_id": "Q1ZXA1", "name": "cyp521A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293738", "map_id": "DDB_G0293738", "name": "cyp521A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SK0", "map_id": "Q54SK0", "name": "cyp508B1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282419", "map_id": "DDB_G0282419", "name": "cyp508B1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXA4", "map_id": "Q1ZXA4", "name": "cyp508D1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292790", "map_id": "DDB_G0292790", "name": "cyp508D1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SV9", "map_id": "Q54SV9", "name": "cyp515B1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282283", "map_id": "DDB_G0282283", "name": "cyp515B1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXF3", "map_id": "Q1ZXF3", "name": "cyp517A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284647", "map_id": "DDB_G0284647", "name": "cyp517A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ZM4", "map_id": "Q54ZM4", "name": "cyp518A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277545", "map_id": "DDB_G0277545", "name": "cyp518A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXF5", "map_id": "Q1ZXF5", "name": "cyp508A4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q556M4", "map_id": "Q556M4", "name": "cyp508A2-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272604", "map_id": "DDB_G0272604", "name": "cyp508A2-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXG3", "map_id": "Q1ZXG3", "name": "cyp522A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282769", "map_id": "DDB_G0282769", "name": "cyp522A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q556M5", "map_id": "Q556M5", "name": "cyp508A1-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273045", "map_id": "DDB_G0273045", "name": "cyp508A1-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXL2", "map_id": "Q1ZXL2", "name": "cyp518B1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275197", "map_id": "DDB_G0275197", "name": "cyp518B1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AJ4", "map_id": "Q55AJ4", "name": "cyp516B1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271778", "map_id": "DDB_G0271778", "name": "cyp516B1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXL7", "map_id": "Q1ZXL7", "name": "cyp508A3-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273047", "map_id": "DDB_G0273047", "name": "cyp508A3-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86A22", "map_id": "Q86A22", "name": "cyp515A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272704", "map_id": "DDB_G0272704", "name": "cyp515A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CS3", "map_id": "Q54CS3", "name": "cyp508C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292792", "map_id": "DDB_G0292792", "name": "cyp508C1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DT2", "map_id": "Q54DT2", "name": "cyp516A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292168", "map_id": "DDB_G0292168", "name": "cyp516A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54EM5", "map_id": "Q54EM5", "name": "cyp519D1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291448", "map_id": "DDB_G0291448", "name": "cyp519D1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LA8", "map_id": "Q54LA8", "name": "cyp555A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286743", "map_id": "DDB_G0286743", "name": "cyp555A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LT7", "map_id": "Q54LT7", "name": "cyp519E1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286419", "map_id": "DDB_G0286419", "name": "cyp519E1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NY3", "map_id": "Q54NY3", "name": "cyp554A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284923", "map_id": "DDB_G0284923", "name": "cyp554A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Q53", "map_id": "Q54Q53", "name": "cyp519B1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284089", "map_id": "DDB_G0284089", "name": "cyp519B1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10600471", "map_id": "none", "name": "EET(1) is hydrolysed to DHET(1) by EPHX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2161818", "map_id": "none", "name": "EET(1)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:34130", "map_id": "CHEBI:34130", "name": "CHEBI:34130", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:34490", "map_id": "CHEBI:34490", "name": "CHEBI:34490", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:34157", "map_id": "CHEBI:34157", "name": "CHEBI:34157", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_2161883", "map_id": "none", "name": "DHET(1)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:63974", "map_id": "CHEBI:63974", "name": "CHEBI:63974", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:63969", "map_id": "CHEBI:63969", "name": "CHEBI:63969", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:63970", "map_id": "CHEBI:63970", "name": "CHEBI:63970", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:63966", "map_id": "CHEBI:63966", "name": "CHEBI:63966", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10600468", "map_id": "none", "name": "EPHX2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54T91", "map_id": "Q54T91", "name": "EPHX2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281917", "map_id": "DDB_G0281917", "name": "EPHX2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10600440", "map_id": "none", "name": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2161753", "map_id": "none", "name": "8,9/11,12/14,15-EET", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10600437", "map_id": "none", "name": "CYP(5)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10600432", "map_id": "none", "name": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_113534", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_156540", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_140356", "map_id": "CHEBI:15843", "name": "ARA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2142836", "map_id": "CHEBI:63998", "name": "19-HETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10600429", "map_id": "none", "name": "CYP(2)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10600447", "map_id": "none", "name": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2142780", "map_id": "CHEBI:34306", "name": "20-HETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10588851", "map_id": "none", "name": "Homologues of CYP2U1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10589155", "map_id": "none", "name": "LTA4 is hydolysed to LTB4 by LTA4H", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_265281", "map_id": "CHEBI:15651", "name": "LTA4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_266056", "map_id": "CHEBI:15647", "name": "LTB4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10589152", "map_id": "none", "name": "LTA4H:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P52922", "map_id": "P52922", "name": "lkhA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269148", "map_id": "DDB_G0269148", "name": "lkhA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10600500", "map_id": "none", "name": "LTA4 is converted to EXA4 by ALOX15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2142772", "map_id": "CHEBI:63983", "name": "EXA4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10600479", "map_id": "none", "name": "ALOX15:Fe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10589113", "map_id": "none", "name": "LTA4 is converted to LTC4 by LTC4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_266066", "map_id": "CHEBI:16978", "name": "LTC4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10589145", "map_id": "none", "name": "LTC4 is exported from the cytosol by ABCC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_266013", "map_id": "CHEBI:16978", "name": "LTC4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10589142", "map_id": "none", "name": "Homologues of ABCC1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10589115", "map_id": "none", "name": "5S-HpETE is dehydrated to LTA4 by ALOX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10600410", "map_id": "none", "name": "EXA4 is converted to EXC4 by LTC4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2142726", "map_id": "CHEBI:63984", "name": "EXC4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10600497", "map_id": "none", "name": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2142718", "map_id": "CHEBI:15628", "name": "15S-HpETE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10600494", "map_id": "none", "name": "ALOX15/15B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10623250", "map_id": "none", "name": "ALOXE3 isomerises 12R-HpETE to HXA3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2142790", "map_id": "CHEBI:34145", "name": "12R-HpETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10623247", "map_id": "none", "name": "Homologues of ALOXE3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10600450", "map_id": "none", "name": "Arachidonic acid is converted to 12-oxoETE by ALOX12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2142745", "map_id": "CHEBI:34151", "name": "12-oxoETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10600484", "map_id": "none", "name": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2142811", "map_id": "CHEBI:15626", "name": "12S-HpETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10600481", "map_id": "none", "name": "ALOX12/15", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10600461", "map_id": "none", "name": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10600458", "map_id": "none", "name": "ALOX12B:Fe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10594017", "map_id": "none", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_76103", "map_id": "CHEBI:17815", "name": "DAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_549167", "map_id": "CHEBI:17855", "name": "TAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10594014", "map_id": "Q54GC1", "name": "dgat2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10611920", "map_id": "none", "name": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_5696122", "map_id": "CHEBI:52575", "name": "alkylglycerol", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_76116", "map_id": "CHEBI:17754", "name": "Glycerol", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10611917", "map_id": "Q550E0", "name": "AGMO", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0277137", "map_id": "DDB_G0277137", "name": "AGMO", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10581764", "map_id": "none", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10581761", "map_id": "none", "name": "DGAT1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10581736", "map_id": "none", "name": "Conversion of Glycerol to Glycerol-3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10581731", "map_id": "Q54VT8", "name": "gk", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0280371", "map_id": "DDB_G0280371", "name": "gk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10616072", "map_id": "none", "name": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_6800352", "map_id": "CHEBI:17389", "name": "2AG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10616065", "map_id": "Q54GC1", "name": "dgat2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10581754", "map_id": "none", "name": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10581751", "map_id": "none", "name": "LPIN1,2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10625442", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9022655", "map_id": "CHEBI:138490", "name": "5S,6S-epoxy-18(S)-HEPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9022660", "map_id": "CHEBI:137038", "name": "18(S)-RvE1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10625439", "map_id": "none", "name": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9020602", "map_id": "CHEBI:132802", "name": "5(S)-Hp-18(S)-HEPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10625485", "map_id": "none", "name": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9020474", "map_id": "CHEBI:132801", "name": "18(S)-HEPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9022679", "map_id": "CHEBI:138477", "name": "18(S)-RvE3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10600477", "map_id": "none", "name": "Homologues of ALOX15", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10625437", "map_id": "none", "name": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10625446", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9023708", "map_id": "CHEBI:138563", "name": "5S,6S-epoxy-18(R)-HEPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9023712", "map_id": "CHEBI:81559", "name": "18(R)-RvE1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10625444", "map_id": "none", "name": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9023651", "map_id": "CHEBI:81563", "name": "18(R)-HEPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9023702", "map_id": "CHEBI:132908", "name": "5(S)-Hp-18(R)-HEPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10625451", "map_id": "none", "name": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9023644", "map_id": "CHEBI:138542", "name": "(18R)-resolvin E3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10625448", "map_id": "none", "name": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10625505", "map_id": "none", "name": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9025155", "map_id": "CHEBI:65136", "name": "DPAn-6", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9025960", "map_id": "CHEBI:140218", "name": "14(S)-HDPAn-6", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10625503", "map_id": "none", "name": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9025151", "map_id": "none", "name": "17(S)-HDPAn-6, 10(S),17(S)-diHDPAn-6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:138674", "map_id": "CHEBI:138674", "name": "CHEBI:138674", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:138673", "map_id": "CHEBI:138673", "name": "CHEBI:138673", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625507", "map_id": "none", "name": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9026034", "map_id": "CHEBI:140248", "name": "7,17-diHp-DPAn-3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9026050", "map_id": "CHEBI:140234", "name": "7,8-epoxy,17-HDPAn-3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10625511", "map_id": "none", "name": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9026047", "map_id": "CHEBI:140226", "name": "17(S)-Hp-DPAn-3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9026046", "map_id": "CHEBI:140224", "name": "16(S),17(S)-epoxy-DPAn-3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10625509", "map_id": "none", "name": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10625513", "map_id": "none", "name": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10625521", "map_id": "none", "name": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9026400", "map_id": "CHEBI:91274", "name": "13(R)-HDPAn-3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9026394", "map_id": "none", "name": "RvT1-4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:137020", "map_id": "CHEBI:137020", "name": "CHEBI:137020", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:137011", "map_id": "CHEBI:137011", "name": "CHEBI:137011", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:137018", "map_id": "CHEBI:137018", "name": "CHEBI:137018", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:137019", "map_id": "CHEBI:137019", "name": "CHEBI:137019", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625547", "map_id": "none", "name": "ALOX5 oxidises EPA to 5-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2026977", "map_id": "CHEBI:28364", "name": "EPA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9028283", "map_id": "CHEBI:72801", "name": "5-HEPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10625545", "map_id": "none", "name": "ALOX5 oxidises DHA to 7-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024011", "map_id": "CHEBI:28125", "name": "DHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9028274", "map_id": "CHEBI:72623", "name": "7-HDHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10625549", "map_id": "none", "name": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9028240", "map_id": "CHEBI:140250", "name": "7-HDPAn-3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10600424", "map_id": "none", "name": "ALOX12 oxidises LTA4 to LXA4/B4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9032038", "map_id": "CHEBI:15651", "name": "LTA4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2161856", "map_id": "none", "name": "LXA4/B4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:6499", "map_id": "CHEBI:6499", "name": "CHEBI:6499", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:6498", "map_id": "CHEBI:6498", "name": "CHEBI:6498", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10600443", "map_id": "none", "name": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2142738", "map_id": "CHEBI:63989", "name": "15R-HETE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2161609", "map_id": "none", "name": "15epi-LXA4/B4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:63991", "map_id": "CHEBI:63991", "name": "CHEBI:63991", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:63990", "map_id": "CHEBI:63990", "name": "CHEBI:63990", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10600445", "map_id": "none", "name": "ALOX5 oxidises 15S-HpETE to LXA4/B4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10625475", "map_id": "none", "name": "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10625473", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024577", "map_id": "CHEBI:138612", "name": "4S(5)-epoxy-17(R)-HDHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024570", "map_id": "none", "name": "AT-RvD3, AT-RvD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:138615", "map_id": "CHEBI:138615", "name": "CHEBI:138615", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:138616", "map_id": "CHEBI:138616", "name": "CHEBI:138616", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625461", "map_id": "none", "name": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024479", "map_id": "CHEBI:138602", "name": "7(S)-Hp-17(R)-HDHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024602", "map_id": "CHEBI:138613", "name": "7S(8)-epoxy-17(R)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10625467", "map_id": "none", "name": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024463", "map_id": "CHEBI:91137", "name": "17(R)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024576", "map_id": "CHEBI:138601", "name": "4(S)-Hp-17(R)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10625481", "map_id": "none", "name": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10625455", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024574", "map_id": "none", "name": "AT-RvD1, AT-RvD2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:138179", "map_id": "CHEBI:138179", "name": "CHEBI:138179", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:138614", "map_id": "CHEBI:138614", "name": "CHEBI:138614", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625453", "map_id": "none", "name": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10625477", "map_id": "none", "name": "ALOX15 oxidises DHA to 17(S)-Hp-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024012", "map_id": "CHEBI:136113", "name": "17(S)-Hp-DHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10625493", "map_id": "none", "name": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024873", "map_id": "CHEBI:140225", "name": "16S,17S-epoxy-DHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10625459", "map_id": "none", "name": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024765", "map_id": "CHEBI:138642", "name": "7(S)-Hp-17(S)-HDHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024768", "map_id": "CHEBI:138646", "name": "7S(8)-epoxy-17(S)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10625457", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024781", "map_id": "CHEBI:138647", "name": "4S(5)-epoxy-17(S)-HDHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024809", "map_id": "none", "name": "RvD3, RvD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:138649", "map_id": "CHEBI:138649", "name": "CHEBI:138649", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:138648", "map_id": "CHEBI:138648", "name": "CHEBI:138648", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625479", "map_id": "none", "name": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024797", "map_id": "CHEBI:138641", "name": "4(S)-Hp-17(S)-HDHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10625483", "map_id": "none", "name": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024815", "map_id": "CHEBI:138640", "name": "17(S)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10625465", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024759", "map_id": "none", "name": "RvD1, RvD2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:81565", "map_id": "CHEBI:81565", "name": "CHEBI:81565", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:81564", "map_id": "CHEBI:81564", "name": "CHEBI:81564", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625471", "map_id": "none", "name": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10625497", "map_id": "none", "name": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9025001", "map_id": "CHEBI:132228", "name": "13(S),14(S)-epoxy-DHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10625538", "map_id": "none", "name": "CYPs hydroxylate DHA to 14(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9027049", "map_id": "CHEBI:137346", "name": "14(R)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10625535", "map_id": "none", "name": "CYP1A2,2C8,2C9,2D6,2E1,3A4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10625543", "map_id": "none", "name": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9027324", "map_id": "none", "name": "14(R),21(S/R)-diHDHA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:137368", "map_id": "CHEBI:137368", "name": "CHEBI:137368", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:137361", "map_id": "CHEBI:137361", "name": "CHEBI:137361", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10582018", "map_id": "none", "name": "Homologues of CYP2E1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10625541", "map_id": "none", "name": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9027029", "map_id": "CHEBI:137347", "name": "14(S)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9027326", "map_id": "none", "name": "14(S),21(S/R)-diHDHA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:137360", "map_id": "CHEBI:137360", "name": "CHEBI:137360", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:137354", "map_id": "CHEBI:137354", "name": "CHEBI:137354", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10625499", "map_id": "none", "name": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9025011", "map_id": "CHEBI:138248", "name": "MaR2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10625501", "map_id": "none", "name": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024989", "map_id": "CHEBI:140196", "name": "7(S),14(S)-diHp-DHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10625533", "map_id": "none", "name": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9026915", "map_id": "CHEBI:140268", "name": "RCTR1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10625528", "map_id": "none", "name": "LTC4S trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10625524", "map_id": "none", "name": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9026761", "map_id": "CHEBI:138202", "name": "MCTR1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10585637", "map_id": "none", "name": "GSTM1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10625531", "map_id": "none", "name": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10625491", "map_id": "none", "name": "ALOX15 oxidises 17(S)-Hp-DHA to PDX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024883", "map_id": "CHEBI:138653", "name": "PDX", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10625495", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024886", "map_id": "CHEBI:138655", "name": "(N)PD1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10625463", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024893", "map_id": "CHEBI:140192", "name": "17R(16)-epoxy-DHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024879", "map_id": "CHEBI:140202", "name": "AT-(N)PD1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10625469", "map_id": "none", "name": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024522", "map_id": "CHEBI:138590", "name": "17(R)-Hp-DHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10591619", "map_id": "none", "name": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428163", "map_id": "CHEBI:16566", "name": "SPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_428275", "map_id": "CHEBI:16893", "name": "SPAP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10591616", "map_id": "none", "name": "SPHK", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54HN2", "map_id": "Q54HN2", "name": "SPHK2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289343", "map_id": "DDB_G0289343", "name": "SPHK2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86KF9", "map_id": "Q86KF9", "name": "sgkA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272522", "map_id": "DDB_G0272522", "name": "sgkA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10591683", "map_id": "none", "name": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428203", "map_id": "CHEBI:37550", "name": "S1P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_428671", "map_id": "CHEBI:17585", "name": "HD2NAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10591680", "map_id": "Q54RV9", "name": "sglA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0282819", "map_id": "DDB_G0282819", "name": "sglA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10611267", "map_id": "none", "name": "ALDH3A2-1 oxidises HD2NAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10611264", "map_id": "none", "name": "ALDH3A2-1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10591685", "map_id": "none", "name": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428663", "map_id": "CHEBI:17600", "name": "HXAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10624103", "map_id": "none", "name": "SAMD8 transforms PE and CERA to CPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8959490", "map_id": "CHEBI:16038", "name": "PE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_8959486", "map_id": "CHEBI:17761", "name": "CERA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_8959463", "map_id": "CHEBI:73204", "name": "CPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10624100", "map_id": "Q54B63", "name": "SAMD8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0293880", "map_id": "DDB_G0293880", "name": "SAMD8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10591627", "map_id": "none", "name": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428206", "map_id": "none", "name": "NAD(P)H", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_428126", "map_id": "CHEBI:31488", "name": "DHCE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_428218", "map_id": "none", "name": "NAD(P)+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_428256", "map_id": "CHEBI:17761", "name": "CERA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10591624", "map_id": "Q55D94", "name": "DEGS1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0269738", "map_id": "DDB_G0269738", "name": "DEGS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10591819", "map_id": "none", "name": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_429802", "map_id": "CHEBI:16110", "name": "PC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10591816", "map_id": "Q54B63", "name": "2xPalmC-SGMS2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10611887", "map_id": "none", "name": "ALDH3B1 oxidises HXAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10611884", "map_id": "Q54DG1", "name": "comG", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10591630", "map_id": "none", "name": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9025544", "map_id": "CHEBI:31998", "name": "N-acylphytosphingosine", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10591726", "map_id": "none", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428682", "map_id": "CHEBI:16393", "name": "SPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10591723", "map_id": "none", "name": "PPAP2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54PR7", "map_id": "Q54PR7", "name": "PPAP2A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284367", "map_id": "DDB_G0284367", "name": "PPAP2A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86AF0", "map_id": "Q86AF0", "name": "PPAP2A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MXL9", "map_id": "Q8MXL9", "name": "PPAP2A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10591729", "map_id": "none", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10591669", "map_id": "Q55A00", "name": "sppA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0272260", "map_id": "DDB_G0272260", "name": "sppA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10591824", "map_id": "none", "name": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_428270", "map_id": "CHEBI:17761", "name": "CERA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_429773", "map_id": "CHEBI:18035", "name": "DAGs", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_429789", "map_id": "CHEBI:17636", "name": "SPHM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10591821", "map_id": "Q54B63", "name": "SGMS1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10591600", "map_id": "none", "name": "sphinganine + stearyl-CoA => dihydroceramide + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10591587", "map_id": "Q54S87", "name": "crsA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0282607", "map_id": "DDB_G0282607", "name": "crsA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10616950", "map_id": "none", "name": "ALDH3B2 oxidises HXAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13977", "compartment_display": "lipid droplet" }, { "id": "species_6808468", "map_id": "CHEBI:17600", "name": "HXAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "false" }, { "id": "species_2453691", "map_id": "CHEBI:15756", "name": "PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "false" }, { "id": "species_10616947", "map_id": "Q54DG1", "name": "comG", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "false" }, { "id": "reaction_10591638", "map_id": "none", "name": "phytoceramide + H2O => stearate + phytosphingosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428237", "map_id": "CHEBI:46961", "name": "phytosphingosine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_3632878", "map_id": "CHEBI:9254", "name": "STEA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10591635", "map_id": "Q6TMJ1", "name": "dcd3A", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0288359", "map_id": "DDB_G0288359", "name": "dcd3A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10591641", "map_id": "none", "name": "SPHK1 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428193", "map_id": "CHEBI:16393", "name": "SPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10591705", "map_id": "none", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_419305", "map_id": "CHEBI:37550", "name": "S1P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_109277", "map_id": "CHEBI:43474", "name": "Pi", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10591702", "map_id": "none", "name": "Homologues of PPAP2A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10591674", "map_id": "none", "name": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428694", "map_id": "CHEBI:16566", "name": "SPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10611452", "map_id": "none", "name": "FA2H hydroxylates CERA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_5693768", "map_id": "CHEBI:85781", "name": "2HCERA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10611449", "map_id": "Q55CT7", "name": "FA2H", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0269908", "map_id": "DDB_G0269908", "name": "FA2H", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10627391", "map_id": "none", "name": "SPHK2 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10591614", "map_id": "none", "name": "Homologues of SPHK2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10627389", "map_id": "none", "name": "SPHK2:SPHK2 inhibitors", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10591582", "map_id": "none", "name": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428182", "map_id": "CHEBI:17862", "name": "3-ketosphinganine", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10591579", "map_id": "Q54I21", "name": "KDSR", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0289061", "map_id": "DDB_G0289061", "name": "KDSR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586816", "map_id": "none", "name": "2xTPK1:Mg2+ phosphorylates THMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_196934", "map_id": "CHEBI:18385", "name": "THMN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29480", "map_id": "CHEBI:58937", "name": "ThDP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10586813", "map_id": "none", "name": "2xTPK1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55GR8", "map_id": "Q55GR8", "name": "TPK1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267546", "map_id": "DDB_G0267546", "name": "TPK1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10587239", "map_id": "none", "name": "SLC19A2/3 transport extracellular THMN to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_199622", "map_id": "CHEBI:18385", "name": "THMN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10587236", "map_id": "none", "name": "SLC19A2/3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q559K0", "map_id": "Q559K0", "name": "SLC19A3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272544", "map_id": "DDB_G0272544", "name": "SLC19A3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622123", "map_id": "none", "name": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space" }, { "id": "species_10622120", "map_id": "Q54VS7", "name": "mcfK", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0280161", "map_id": "DDB_G0280161", "name": "mcfK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10587154", "map_id": "none", "name": "SLC2A1,3 transports DeHA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_198852", "map_id": "CHEBI:58539", "name": "DeHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_198827", "map_id": "CHEBI:58539", "name": "DeHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10587151", "map_id": "none", "name": "SLC2A1,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10587173", "map_id": "none", "name": "CYB5A:heme reduces Asc.- to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1497805", "map_id": "CHEBI:59513", "name": "Asc.-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10587170", "map_id": "none", "name": "CYB5A:heme", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q54XT7", "map_id": "Q54XT7", "name": "cyb5C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278753", "map_id": "DDB_G0278753", "name": "cyb5C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86L22", "map_id": "Q86L22", "name": "cyb5B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277079", "map_id": "DDB_G0277079", "name": "cyb5B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10587168", "map_id": "none", "name": "CYB5A:ferriheme", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "CHEBI:36144", "map_id": "CHEBI:36144", "name": "CHEBI:36144", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10587189", "map_id": "none", "name": "Phosphopantetheine conjugation of the ACP domain of FAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10587181", "map_id": "none", "name": "Homologues of FASN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_158466", "map_id": "CHEBI:17985", "name": "PAP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10587186", "map_id": "Q54MI2", "name": "AASDHPPT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0285927", "map_id": "DDB_G0285927", "name": "AASDHPPT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10623045", "map_id": "none", "name": "Vanin hydrolyses pantetheine to PanK, 2AET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8938313", "map_id": "CHEBI:16753", "name": "Pantetheine", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_196820", "map_id": "CHEBI:7916", "name": "PanK", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10623042", "map_id": "none", "name": "VNN1,VNN2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10586819", "map_id": "none", "name": "COASY phosphorylates DP-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_196778", "map_id": "CHEBI:15468", "name": "DP-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10586803", "map_id": "Q54IX0", "name": "COASY", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "DDB_G0288465", "map_id": "DDB_G0288465", "name": "COASY", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586806", "map_id": "none", "name": "COASY transfers an adenylyl group from ATP to PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_196767", "map_id": "CHEBI:16858", "name": "PPANT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10586829", "map_id": "none", "name": "3xPPCDC:3FMN decarboxylates PPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_196834", "map_id": "CHEBI:15769", "name": "PPC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10586826", "map_id": "none", "name": "3xPPCDC:3xFMN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54Y51", "map_id": "Q54Y51", "name": "ppcdc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278413", "map_id": "DDB_G0278413", "name": "ppcdc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10587197", "map_id": "none", "name": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10587194", "map_id": "Q54DU1", "name": "mcfP", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0292034", "map_id": "DDB_G0292034", "name": "mcfP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586798", "map_id": "none", "name": "2xPPCS ligates PPanK with Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_196786", "map_id": "CHEBI:15905", "name": "PPanK", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10586795", "map_id": "none", "name": "2xPPCS", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54S85", "map_id": "Q54S85", "name": "PPCS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282611", "map_id": "DDB_G0282611", "name": "PPCS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10595303", "map_id": "none", "name": "Exchange of oxygen with sulfur in MoCo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_947575", "map_id": "CHEBI:60102", "name": "sulfurated MoCo", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10595300", "map_id": "Q559G8", "name": "mocos", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0272935", "map_id": "DDB_G0272935", "name": "mocos", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10595350", "map_id": "none", "name": "Cyclisation of GTP to precursor Z", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_947537", "map_id": "CHEBI:59648", "name": "Precursor Z", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_947703", "map_id": "CHEBI:17319", "name": "dADE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10595347", "map_id": "none", "name": "holo-MOCS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54NM6", "map_id": "Q54NM6", "name": "mocs1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285137", "map_id": "DDB_G0285137", "name": "mocs1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:33722", "map_id": "CHEBI:33722", "name": "CHEBI:33722", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10595338", "map_id": "none", "name": "Molybdenum ion transfer onto molybdopterin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_947561", "map_id": "CHEBI:36264", "name": "MoO4(2-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_947496", "map_id": "CHEBI:58698", "name": "MPT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10595335", "map_id": "none", "name": "3xGPHN:3xMg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54KM0", "map_id": "Q54KM0", "name": "gphn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287261", "map_id": "DDB_G0287261", "name": "gphn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10595326", "map_id": "none", "name": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10595310", "map_id": "none", "name": "MOCS3:Zn2+ (red.)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55FS0", "map_id": "Q55FS0", "name": "mocs3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267980", "map_id": "DDB_G0267980", "name": "mocs3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10595315", "map_id": "none", "name": "MOCS3-S-S(1-):Zn2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10595323", "map_id": "none", "name": "PXLP-K258-NFS1-2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10595424", "map_id": "none", "name": "2xPDXK:2xZn2+ phosphorylates PXL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_965131", "map_id": "CHEBI:17310", "name": "PXL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29390", "map_id": "CHEBI:18405", "name": "PXLP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10595417", "map_id": "none", "name": "2xPDXK:2xZn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55EK9", "map_id": "Q55EK9", "name": "pykA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268628", "map_id": "DDB_G0268628", "name": "pykA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10602082", "map_id": "none", "name": "AOX1 oxidises PXL to PDXate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_3204324", "map_id": "CHEBI:17405", "name": "PDXate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10602079", "map_id": "none", "name": "2xAOX1:cofactors", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10595434", "map_id": "none", "name": "2xPNPO:2xFMN oxidizes PDXP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_964952", "map_id": "CHEBI:28803", "name": "PDXP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10595431", "map_id": "none", "name": "2xPNPO:2xFMN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54YS6", "map_id": "Q54YS6", "name": "pnpo", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278107", "map_id": "DDB_G0278107", "name": "pnpo", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10595420", "map_id": "none", "name": "2xPDXK:2xZn2+ phosphorylates PXA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_964945", "map_id": "CHEBI:16410", "name": "PXA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_965146", "map_id": "CHEBI:18335", "name": "PXAP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10595436", "map_id": "none", "name": "2xPNPO:2xFMN oxidizes PXAP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10595422", "map_id": "none", "name": "2xPDKX:2xZn2+ phosphorylates PDX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_965053", "map_id": "CHEBI:16709", "name": "PDX", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10603568", "map_id": "none", "name": "Mitochondrial BTD hydrolyses BCTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_3065953", "map_id": "CHEBI:27870", "name": "BCTN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_29582", "map_id": "CHEBI:15956", "name": "Btn", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10603565", "map_id": "Q54WG1", "name": "BTD", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10603574", "map_id": "none", "name": "HLCS biotinylates ACACB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10603572", "map_id": "none", "name": "ACACB:2Mn2+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "species_199207", "map_id": "CHEBI:15956", "name": "Btn", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10587331", "map_id": "none", "name": "Btn-ACACB:2Mn2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "species_10601704", "map_id": "Q54IF5", "name": "HLCS", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0288791", "map_id": "DDB_G0288791", "name": "HLCS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10601752", "map_id": "none", "name": "HLCS biotinylates ACACA:Mn2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10601750", "map_id": "none", "name": "ACACA:2Mn2+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10581619", "map_id": "none", "name": "Btn-ACACA:2Mn2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10601707", "map_id": "none", "name": "HLCS biotinylates 6x(PCCA:PCCB)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10601693", "map_id": "none", "name": "6x(PCCA:PCCB)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10601699", "map_id": "none", "name": "6x(Btn-PCCA:PCCB)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10602666", "map_id": "none", "name": "Cytoslic carboxylases translocate to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10601951", "map_id": "none", "name": "Extracellular BTD hydrolyses BCTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_3076887", "map_id": "CHEBI:27870", "name": "BCTN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_199238", "map_id": "CHEBI:15956", "name": "Btn", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_351991", "map_id": "CHEBI:32551", "name": "L-Lys", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10601948", "map_id": "Q54WG1", "name": "BTD", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10586913", "map_id": "none", "name": "DHF is reduced to tetrahydrofolate (THF)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_73604", "map_id": "CHEBI:15633", "name": "DHF", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10586908", "map_id": "Q54LA0", "name": "DHFR2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0286755", "map_id": "DDB_G0286755", "name": "DHFR2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10616513", "map_id": "none", "name": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5389850", "map_id": "CHEBI:15637", "name": "10-formyl-THF", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_6801451", "map_id": "CHEBI:30751", "name": "HCOOH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10612187", "map_id": "none", "name": "MTHFD1L dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54RI8", "map_id": "Q54RI8", "name": "MTHFD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283121", "map_id": "DDB_G0283121", "name": "MTHFD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VK0", "map_id": "Q54VK0", "name": "MTHFD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10616966", "map_id": "none", "name": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6808499", "map_id": "CHEBI:28010", "name": "10-formyl-THFPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_200679", "map_id": "CHEBI:28624", "name": "THFPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10616963", "map_id": "none", "name": "ADH1L2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54FY1", "map_id": "Q54FY1", "name": "ALDH1B1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290537", "map_id": "DDB_G0290537", "name": "ALDH1B1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FY2", "map_id": "Q54FY2", "name": "ALDH1B1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10616516", "map_id": "none", "name": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6801458", "map_id": "CHEBI:15638", "name": "5,10-methenyl-THF", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10616508", "map_id": "none", "name": "MTHFD2, D2L", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10587398", "map_id": "none", "name": "SLC25A32 transports THF from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10587395", "map_id": "Q86I81", "name": "mcfI", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0271922", "map_id": "DDB_G0271922", "name": "mcfI", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10587400", "map_id": "none", "name": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_200665", "map_id": "CHEBI:15641", "name": "5-methyl-THF", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_174404", "map_id": "CHEBI:63907", "name": "5-methyl-THFPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10586900", "map_id": "Q54CY5", "name": "folC", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0292632", "map_id": "DDB_G0292632", "name": "folC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10587405", "map_id": "none", "name": "Mitochondrial FPGS-1 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10587402", "map_id": "Q54CY5", "name": "folC", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10587372", "map_id": "none", "name": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_200739", "map_id": "CHEBI:60473", "name": "5,10-methylene-THFPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_200640", "map_id": "CHEBI:65049", "name": "5,10-methenyl-THFPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10587369", "map_id": "none", "name": "MTHFD1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10587377", "map_id": "none", "name": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_200709", "map_id": "CHEBI:15641", "name": "5-methyl-THF", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10587374", "map_id": "Q559K0", "name": "SLC19A1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10587408", "map_id": "none", "name": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_197969", "map_id": "CHEBI:28624", "name": "THFPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111353", "map_id": "CHEBI:28010", "name": "10-formyl-THFPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10587410", "map_id": "none", "name": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10616982", "map_id": "none", "name": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10616979", "map_id": "none", "name": "ALDH1L1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10587380", "map_id": "none", "name": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10586903", "map_id": "none", "name": "FPGS-2 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10587414", "map_id": "none", "name": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10627480", "map_id": "none", "name": "DHFR dimer reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_197965", "map_id": "CHEBI:27470", "name": "FOLA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10627477", "map_id": "none", "name": "DHFR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54LA0", "map_id": "Q54LA0", "name": "DHFR2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586911", "map_id": "none", "name": "DHFR2 reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10616511", "map_id": "none", "name": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10612190", "map_id": "none", "name": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10587390", "map_id": "none", "name": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10587387", "map_id": "none", "name": "MTHFR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54X84", "map_id": "Q54X84", "name": "MTHFR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279137", "map_id": "DDB_G0279137", "name": "MTHFR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10601859", "map_id": "none", "name": "LMBRD1 transports lysosomal Cbl to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_3000239", "map_id": "CHEBI:28911", "name": "Cbl", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_3000241", "map_id": "CHEBI:28911", "name": "Cbl", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10601856", "map_id": "Q54KD1", "name": "lmbrd1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "DDB_G0287405", "map_id": "DDB_G0287405", "name": "lmbrd1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10602051", "map_id": "none", "name": "MTRR reduces cob(II)alamin to meCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602048", "map_id": "none", "name": "MTRR:MTR(cob(II)alamin)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_3149479", "map_id": "CHEBI:16304", "name": "cob(II)alamin", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10602067", "map_id": "none", "name": "MMAB transfers adenosyl group from ATP to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_3159274", "map_id": "CHEBI:15266", "name": "PPP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_3159297", "map_id": "CHEBI:18408", "name": "AdoCbl", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10602064", "map_id": "none", "name": "3xMMAB", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54W51", "map_id": "Q54W51", "name": "MMAB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279905", "map_id": "DDB_G0279905", "name": "MMAB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10602084", "map_id": "none", "name": "cob(II)alamin binds to MTRR:MTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602046", "map_id": "none", "name": "MTRR:MTR", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10602054", "map_id": "none", "name": "MMACHC decyanates CNCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10601956", "map_id": "Q86KB5", "name": "MMACHC", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0274205", "map_id": "DDB_G0274205", "name": "MMACHC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_3149505", "map_id": "CHEBI:17439", "name": "CNCbl", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10601958", "map_id": "none", "name": "MMACHC:cob(II)alamin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86KB5", "map_id": "Q86KB5", "name": "MMACHC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_1130611", "map_id": "CHEBI:18407", "name": "HCN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10601961", "map_id": "none", "name": "MMACHC reduces Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10602057", "map_id": "none", "name": "MTR transfers CH3 group from MTHF to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10604780", "map_id": "none", "name": "ABCD4 may transport Cbl from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10604777", "map_id": "Q54W20", "name": "abcD3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "DDB_G0279919", "map_id": "DDB_G0279919", "name": "abcD3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10601964", "map_id": "none", "name": "ABCC1 transports cytosolic Cbl to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_3000125", "map_id": "CHEBI:28911", "name": "Cbl", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10620675", "map_id": "none", "name": "NMRK2 phosphorylates NR to yield NMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8869377", "map_id": "CHEBI:15927", "name": "NR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8869353", "map_id": "CHEBI:14649", "name": "NMN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10620669", "map_id": "none", "name": "Homologues of NMRK2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10620672", "map_id": "none", "name": "NMRK2 phosphorylates NAR to yield NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8869365", "map_id": "CHEBI:58527", "name": "NAR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_197220", "map_id": "CHEBI:15763", "name": "NAMN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10586867", "map_id": "none", "name": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10586864", "map_id": "none", "name": "NADK:Zn2+ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54D76", "map_id": "Q54D76", "name": "NADK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292442", "map_id": "DDB_G0292442", "name": "NADK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586885", "map_id": "none", "name": "QPRT transfers PRIB to QUIN to form NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_197238", "map_id": "CHEBI:29959", "name": "QUIN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10586882", "map_id": "Q75JX0", "name": "qprt", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0272462", "map_id": "DDB_G0272462", "name": "qprt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10620678", "map_id": "none", "name": "NMRK1 phosphorylates NR to yield NMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10620660", "map_id": "none", "name": "Homologues of NMRK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10616677", "map_id": "none", "name": "CARKD dehydrates S-NAD(P)HX to NADPH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6807477", "map_id": "CHEBI:64084", "name": "S-NADPHX", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10616674", "map_id": "Q54FJ9", "name": "CARKD", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0290799", "map_id": "DDB_G0290799", "name": "CARKD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586857", "map_id": "none", "name": "NAPRT1 dimer transfers PRIB to NCA to form NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_197230", "map_id": "CHEBI:15940", "name": "NCA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10586854", "map_id": "none", "name": "NAPRT1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55G10", "map_id": "Q55G10", "name": "naprt", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268472", "map_id": "DDB_G0268472", "name": "naprt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617321", "map_id": "none", "name": "NUDT12 hydrolyses NADH to NMNH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_6809289", "map_id": "CHEBI:74452", "name": "NMNH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10617318", "map_id": "Q55A74", "name": "NUDT12", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "DDB_G0272048", "map_id": "DDB_G0272048", "name": "NUDT12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10623038", "map_id": "none", "name": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8938276", "map_id": "CHEBI:133202", "name": "(ADP-D-ribosyl)(n)-acceptor", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_197277", "map_id": "CHEBI:17154", "name": "NAM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8938282", "map_id": "CHEBI:133203", "name": "(ADP-D-ribosyl)(n+1)-acceptor", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10623035", "map_id": "none", "name": "PARPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54JP6", "map_id": "Q54JP6", "name": "PARP16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287911", "map_id": "DDB_G0287911", "name": "PARP16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10616669", "map_id": "none", "name": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6807473", "map_id": "CHEBI:64085", "name": "R-NADPHX", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10616666", "map_id": "none", "name": "APOA1BP dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q55CV0", "map_id": "Q55CV0", "name": "APOA1BP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269890", "map_id": "DDB_G0269890", "name": "APOA1BP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10620663", "map_id": "none", "name": "NMRK1 phosphorylates NAR to yield NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10587352", "map_id": "none", "name": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_8938083", "map_id": "CHEBI:15763", "name": "NAMN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_8938078", "map_id": "CHEBI:33019", "name": "PPi(3-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_8938090", "map_id": "CHEBI:18304", "name": "NAAD", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10587349", "map_id": "none", "name": "4xNMNAT3:4xMg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54IH4", "map_id": "Q54IH4", "name": "NMNAT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288757", "map_id": "DDB_G0288757", "name": "NMNAT3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10623128", "map_id": "none", "name": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10586874", "map_id": "none", "name": "NMNAT2:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10586877", "map_id": "none", "name": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_197256", "map_id": "CHEBI:18304", "name": "NAAD", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10586895", "map_id": "none", "name": "NADSYN1 hexamer amidates NAAD to NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10586892", "map_id": "none", "name": "NADSYN1 hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54ML1", "map_id": "Q54ML1", "name": "nadsyn1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285877", "map_id": "DDB_G0285877", "name": "nadsyn1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10587359", "map_id": "none", "name": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_200492", "map_id": "CHEBI:15763", "name": "NAMN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_8878981", "map_id": "CHEBI:33019", "name": "PPi(3-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_200499", "map_id": "CHEBI:18304", "name": "NAAD", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10587356", "map_id": "none", "name": "6xNMNAT1:6xZn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10597890", "map_id": "none", "name": "DHNTP is dephosphorylated by PTPS to PTHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1474124", "map_id": "CHEBI:18372", "name": "DHNTP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1475054", "map_id": "CHEBI:15266", "name": "PPP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1474179", "map_id": "CHEBI:17804", "name": "PTHP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10597887", "map_id": "none", "name": "p-PTPS hexamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q1ZXI0", "map_id": "Q1ZXI0", "name": "ptsA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279095", "map_id": "DDB_G0279095", "name": "ptsA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10598274", "map_id": "none", "name": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10598272", "map_id": "none", "name": "SPR dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10597913", "map_id": "none", "name": "Homologues of PRKG2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10597879", "map_id": "none", "name": "GCH1 reduces GTP to dihydroneopterin triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10597876", "map_id": "none", "name": "GCH1 decamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q94465", "map_id": "Q94465", "name": "gchA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288481", "map_id": "DDB_G0288481", "name": "gchA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10597901", "map_id": "none", "name": "PTHP is reduced to BH4 by sepiapterin reductase (SPR)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10597916", "map_id": "none", "name": "PTPS is phosphorylated by cGMP-dependant protein kinase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10597905", "map_id": "none", "name": "PTPS hexamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10600514", "map_id": "none", "name": "DeMQ10H2 is methylated to Q10H2 by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_2162265", "map_id": "CHEBI:15414", "name": "AdoMet", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2162212", "map_id": "CHEBI:64182", "name": "DeMQ10H2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2162252", "map_id": "CHEBI:16680", "name": "AdoHcy", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2162198", "map_id": "CHEBI:64183", "name": "Q10H2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10600511", "map_id": "Q54XD0", "name": "coq3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0279037", "map_id": "DDB_G0279037", "name": "coq3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10600522", "map_id": "none", "name": "PHB and all-E-10PrP2 are combined into DHB by COQ2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_2162214", "map_id": "CHEBI:61011", "name": "all-E-10PrP2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2162213", "map_id": "CHEBI:30763", "name": "PHB", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2162207", "map_id": "CHEBI:64136", "name": "DHB", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10600519", "map_id": "Q54U71", "name": "coq2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0281241", "map_id": "DDB_G0281241", "name": "coq2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10600541", "map_id": "none", "name": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_2162257", "map_id": "CHEBI:17407", "name": "FPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2162256", "map_id": "CHEBI:16584", "name": "IPPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10600538", "map_id": "none", "name": "PDSS1/2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54VJ9", "map_id": "Q54VJ9", "name": "coq1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280293", "map_id": "DDB_G0280293", "name": "coq1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10600525", "map_id": "none", "name": "DHDB is methylated to MHDB by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_2162209", "map_id": "CHEBI:50775", "name": "DHDB", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2162215", "map_id": "CHEBI:50776", "name": "MHDB", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10616648", "map_id": "none", "name": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_6806891", "map_id": "CHEBI:28869", "name": "menadione", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_6806657", "map_id": "CHEBI:57533", "name": "GGPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_6806362", "map_id": "CHEBI:78277", "name": "MK4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_6806656", "map_id": "CHEBI:29888", "name": "PPi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10616645", "map_id": "Q54K99", "name": "ubiad1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0287509", "map_id": "DDB_G0287509", "name": "ubiad1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10600503", "map_id": "none", "name": "carbovir + IMP => carbovir monophosphate + inosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2161514", "map_id": "none", "name": "carbovir", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2161176", "map_id": "none", "name": "carbovir monophosphate", "type": "product", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_83927", "map_id": "CHEBI:17596", "name": "Ino", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10600506", "map_id": "none", "name": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2161185", "map_id": "none", "name": "abacavir", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2162081", "map_id": "CHEBI:64192", "name": "abacavir 5'-carboxylic acid", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10578698", "map_id": "none", "name": "ADH1A:2Zn2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54TC2", "map_id": "Q54TC2", "name": "adh5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281865", "map_id": "DDB_G0281865", "name": "adh5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599457", "map_id": "none", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_994170", "map_id": "CHEBI:16783", "name": "I(1,3,4,5)P4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10599454", "map_id": "none", "name": "PTEN:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10599491", "map_id": "none", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_994123", "map_id": "CHEBI:18228", "name": "I(1,3,4)P3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10599488", "map_id": "none", "name": "Inositol polyphosphate 5-phosphatase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10599381", "map_id": "none", "name": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629741", "map_id": "CHEBI:62918", "name": "I(3,4,6)P3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_994146", "map_id": "CHEBI:16155", "name": "I(1,3,4,6)P4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10599367", "map_id": "none", "name": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10599417", "map_id": "none", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10599414", "map_id": "none", "name": "PLCbz", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10599449", "map_id": "none", "name": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10599288", "map_id": "none", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10599285", "map_id": "none", "name": "ITPKA/B/C", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54TI0", "map_id": "Q54TI0", "name": "ITPKB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281737", "map_id": "DDB_G0281737", "name": "ITPKB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599384", "map_id": "none", "name": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10599547", "map_id": "none", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10599544", "map_id": "none", "name": "PLCdegh", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10599387", "map_id": "none", "name": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10599514", "map_id": "none", "name": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2023856", "map_id": "CHEBI:18348", "name": "PI(4,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10599511", "map_id": "none", "name": "PL(C)D4:3xCa2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54SA1", "map_id": "Q54SA1", "name": "pldZ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282579", "map_id": "DDB_G0282579", "name": "pldZ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54K50", "map_id": "Q54K50", "name": "pldY", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287649", "map_id": "DDB_G0287649", "name": "pldY", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599519", "map_id": "none", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10599516", "map_id": "none", "name": "INPP5(3)/ITPK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10599345", "map_id": "none", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023932", "map_id": "CHEBI:62919", "name": "1-PP-IP5", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_2023931", "map_id": "CHEBI:62923", "name": "1,5-(PP)2-IP4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10599342", "map_id": "none", "name": "IP6K1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10599440", "map_id": "none", "name": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023935", "map_id": "CHEBI:16067", "name": "I(1,4,5,6)P4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_2023901", "map_id": "CHEBI:16322", "name": "I(1,3,4,5,6)P5", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10599437", "map_id": "Q54TI0", "name": "IPMK", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10599568", "map_id": "none", "name": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023922", "map_id": "CHEBI:62928", "name": "5-PP-IP4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_2023948", "map_id": "CHEBI:62931", "name": "1,5-(PP)2-IP3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10599460", "map_id": "none", "name": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023891", "map_id": "CHEBI:16783", "name": "I(1,3,4,5)P4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10599556", "map_id": "none", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023940", "map_id": "CHEBI:30164", "name": "5-PP-IP5", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_2023941", "map_id": "CHEBI:62985", "name": "5-PPP-IP5", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10599463", "map_id": "none", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023929", "map_id": "CHEBI:17401", "name": "IP6", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10599574", "map_id": "none", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023907", "map_id": "CHEBI:16595", "name": "I(1,4,5)P3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10599400", "map_id": "none", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10599397", "map_id": "Q54J22", "name": "IPPK", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10599435", "map_id": "none", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10599565", "map_id": "none", "name": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023892", "map_id": "CHEBI:16155", "name": "I(1,3,4,6)P4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10599473", "map_id": "none", "name": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629731", "map_id": "CHEBI:18169", "name": "I3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10599305", "map_id": "none", "name": "IMPA1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54U72", "map_id": "Q54U72", "name": "impa1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281239", "map_id": "DDB_G0281239", "name": "impa1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10607633", "map_id": "none", "name": "MIOX oxidises Ins to GlcA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2162232", "map_id": "CHEBI:15748", "name": "GlcA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10607630", "map_id": "none", "name": "MIOX:2xFe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54GH4", "map_id": "Q54GH4", "name": "miox", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290161", "map_id": "DDB_G0290161", "name": "miox", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599392", "map_id": "none", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629739", "map_id": "CHEBI:17816", "name": "I(1,4)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10599389", "map_id": "none", "name": "INPP5(4)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10599571", "map_id": "none", "name": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629746", "map_id": "CHEBI:28858", "name": "I(3,4)P2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10599467", "map_id": "none", "name": "INPP1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q869K3", "map_id": "Q869K3", "name": "bpnt1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275663", "map_id": "DDB_G0275663", "name": "bpnt1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599427", "map_id": "none", "name": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629756", "map_id": "CHEBI:4170", "name": "Glc6P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10599424", "map_id": "none", "name": "ISYNA1:NAD+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54N49", "map_id": "Q54N49", "name": "ino1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285505", "map_id": "DDB_G0285505", "name": "ino1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599476", "map_id": "none", "name": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629753", "map_id": "CHEBI:18384", "name": "I4P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10599308", "map_id": "none", "name": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_870330", "map_id": "CHEBI:18297", "name": "I1P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10599550", "map_id": "none", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10599484", "map_id": "none", "name": "Homologues of INPP5B(321-993)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10599470", "map_id": "none", "name": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10599378", "map_id": "none", "name": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_2024008", "map_id": "CHEBI:16322", "name": "I(1,3,4,5,6)P5", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_113551", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2024012", "map_id": "CHEBI:16067", "name": "I(1,4,5,6)P4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10599375", "map_id": "Q54L08", "name": "MINPP1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "DDB_G0286993", "map_id": "DDB_G0286993", "name": "MINPP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10599559", "map_id": "none", "name": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_2024018", "map_id": "CHEBI:17401", "name": "IP6", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2564836", "map_id": "CHEBI:16507", "name": "I(1,2,4,5,6)P5", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10599452", "map_id": "none", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_2024002", "map_id": "CHEBI:16783", "name": "I(1,3,4,5)P4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2024016", "map_id": "CHEBI:16595", "name": "I(1,4,5)P3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10583665", "map_id": "none", "name": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5423605", "map_id": "CHEBI:2504", "name": "AFB1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_159211", "map_id": "CHEBI:30725", "name": "AFXBO", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10582258", "map_id": "none", "name": "Homologues of CYP2A6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10605385", "map_id": "none", "name": "ACY1:Zn2+ dimer hydrolyses mercapturic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5490236", "map_id": "none", "name": "AFXBO-NAC,AFNBO-NAC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:78580", "map_id": "CHEBI:78580", "name": "CHEBI:78580", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:78585", "map_id": "CHEBI:78585", "name": "CHEBI:78585", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5490231", "map_id": "none", "name": "AFXBO-C,AFNBO-C", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:78583", "map_id": "CHEBI:78583", "name": "CHEBI:78583", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:78578", "map_id": "CHEBI:78578", "name": "CHEBI:78578", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10605382", "map_id": "none", "name": "ACY1:Zn2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55DP8", "map_id": "Q55DP8", "name": "acy1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270562", "map_id": "DDB_G0270562", "name": "acy1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10605373", "map_id": "none", "name": "CYP2A13 oxidises AFM1 to AFM1E", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5423629", "map_id": "CHEBI:78576", "name": "AFM1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5423657", "map_id": "CHEBI:78577", "name": "AFM1E", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10605375", "map_id": "none", "name": "MGST trimers transfer GS from GSH to AFXBO and AFNBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5423723", "map_id": "none", "name": "AFXBO,AFNBO", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:78586", "map_id": "CHEBI:78586", "name": "CHEBI:78586", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5423730", "map_id": "none", "name": "AFXBO-SG,AFNBO-SG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:78581", "map_id": "CHEBI:78581", "name": "CHEBI:78581", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:78587", "map_id": "CHEBI:78587", "name": "CHEBI:78587", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10585705", "map_id": "none", "name": "MGST2 trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10623024", "map_id": "none", "name": "CES3 hydrolyses CHEST to CHOL and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_163579", "map_id": "CHEBI:17002", "name": "CHEST", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "false" }, { "id": "species_8876730", "map_id": "CHEBI:57560", "name": "LCFA(-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_216762", "map_id": "CHEBI:16113", "name": "CHOL", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10623021", "map_id": "none", "name": "Homologues of CES3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10583621", "map_id": "none", "name": "MAOB:FAD oxidatively deaminates of PEA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500605", "map_id": "CHEBI:18397", "name": "PEA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_500607", "map_id": "CHEBI:16424", "name": "Phenylacetaldehyde", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10583618", "map_id": "none", "name": "MAOB:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q54IT3", "map_id": "Q54IT3", "name": "maoA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288541", "map_id": "DDB_G0288541", "name": "maoA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10583623", "map_id": "none", "name": "MAOB:FAD oxidatively deaminates TYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500606", "map_id": "CHEBI:15760", "name": "TYR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_500608", "map_id": "CHEBI:15621", "name": "HPHAC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10611904", "map_id": "none", "name": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113532", "map_id": "CHEBI:15343", "name": "CH3CHO", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10611901", "map_id": "none", "name": "ALDH1B1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10578691", "map_id": "none", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29510", "map_id": "CHEBI:15343", "name": "CH3CHO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10578727", "map_id": "none", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10578745", "map_id": "none", "name": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10578742", "map_id": "Q54Z60", "name": "acsA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0277815", "map_id": "DDB_G0277815", "name": "acsA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10578717", "map_id": "none", "name": "ethanol + NAD+ => acetaldehyde + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30203", "map_id": "CHEBI:16236", "name": "EtOH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10578714", "map_id": "none", "name": "alcohol dehydrogenase complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10611260", "map_id": "none", "name": "ADH5 oxidises S-HMGSH to S-FGSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5692221", "map_id": "CHEBI:48926", "name": "S-HMGSH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5692249", "map_id": "CHEBI:16225", "name": "S-FGSH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10611257", "map_id": "none", "name": "ADH5:2xZn2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10593006", "map_id": "none", "name": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10593003", "map_id": "Q54Z60", "name": "acsA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10588946", "map_id": "none", "name": "FMO2:FAD:Mg2+ S-oxidises MTZ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_217315", "map_id": "CHEBI:50673", "name": "MTZ", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_217320", "map_id": "CHEBI:63828", "name": "MTZ-SOX", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10588943", "map_id": "none", "name": "FMO2:FAD:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54GT1", "map_id": "Q54GT1", "name": "FMO2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289931", "map_id": "DDB_G0289931", "name": "FMO2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GT2", "map_id": "Q54GT2", "name": "FMO2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GT4", "map_id": "Q54GT4", "name": "FMO2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54H02", "map_id": "Q54H02", "name": "FMO2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54H99", "map_id": "Q54H99", "name": "FMO2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AS8", "map_id": "Q55AS8", "name": "FMO2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GT0", "map_id": "Q54GT0", "name": "FMO2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10588925", "map_id": "none", "name": "FMO1:FAD N-oxidises TAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_159154", "map_id": "CHEBI:41774", "name": "TAM", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_217269", "map_id": "CHEBI:63825", "name": "TAMO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10588922", "map_id": "none", "name": "FMO1:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10583597", "map_id": "none", "name": "FMO3:FAD N-oxidises TMA to TMAO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_30373", "map_id": "CHEBI:18139", "name": "TMA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_140963", "map_id": "CHEBI:15724", "name": "TMAO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10583594", "map_id": "none", "name": "FMO3:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10611272", "map_id": "none", "name": "ALD3A1 oxidises 4HPCP to CXPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5692409", "map_id": "CHEBI:196991", "name": "4HPCP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5692433", "map_id": "CHEBI:3410", "name": "CXPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10611269", "map_id": "Q54DG1", "name": "comG", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10608763", "map_id": "none", "name": "AADAC deacetylates PHEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_5689006", "map_id": "CHEBI:8050", "name": "PHEN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5689001", "map_id": "CHEBI:40574", "name": "acetyl group", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5688995", "map_id": "CHEBI:85505", "name": "4-ethoxyaniline", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10608760", "map_id": "Q54QI3", "name": "AADAC", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0283819", "map_id": "DDB_G0283819", "name": "NCEH1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10611434", "map_id": "none", "name": "CES1 trimer.CES2 hydrolyse COCN to BEG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_5693702", "map_id": "CHEBI:27958", "name": "COCN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_5693711", "map_id": "CHEBI:17790", "name": "MeOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_5693712", "map_id": "CHEBI:41001", "name": "BEG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10611431", "map_id": "none", "name": "CES1 trimer, CES2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10588801", "map_id": "none", "name": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_211906", "map_id": "CHEBI:45863", "name": "PTXL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_211894", "map_id": "CHEBI:63859", "name": "HPTXL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10588798", "map_id": "none", "name": "Cytochrome P450 (CYP2C8 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10588881", "map_id": "none", "name": "CYP2F1 dehydrogenates 3-methylindole", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_213162", "map_id": "CHEBI:9171", "name": "MIND", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_213163", "map_id": "CHEBI:63905", "name": "3MEIN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10588871", "map_id": "none", "name": "Cytochrome P450 (CYP2B6 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10588803", "map_id": "none", "name": "CYP2C19 5-hydroxylates omeprazole", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_211892", "map_id": "CHEBI:7772", "name": "Losec", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_211944", "map_id": "CHEBI:63840", "name": "HOMZ", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10582274", "map_id": "none", "name": "Coumarin is 7-hydroxylated by CYP2A6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_76328", "map_id": "CHEBI:28794", "name": "COUM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_76452", "map_id": "CHEBI:27510", "name": "HCOU", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10582271", "map_id": "none", "name": "Cytochrome P450 (CYP2A3 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10588869", "map_id": "none", "name": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_211855", "map_id": "CHEBI:27999", "name": "TBM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_211937", "map_id": "CHEBI:63799", "name": "HTOLB", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10582327", "map_id": "none", "name": "O-atom dealkylation of dextromethorphan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_39703", "map_id": "none", "name": "DEXM", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_143501", "map_id": "CHEBI:16842", "name": "CH2O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_76455", "map_id": "none", "name": "DEXT", "type": "product", "sub_type": "other", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10582324", "map_id": "none", "name": "Cytochrome P450 (CYP2D6 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10588857", "map_id": "none", "name": "CYP2D6 4-hydroxylates debrisoquine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_211993", "map_id": "CHEBI:34665", "name": "DSQ", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_211952", "map_id": "CHEBI:63800", "name": "HDBQ", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10582263", "map_id": "none", "name": "Vinyl chloride is oxidized to 2-Chloroethylene oxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_39417", "map_id": "CHEBI:28509", "name": "VC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_156524", "map_id": "CHEBI:29129", "name": "2CEO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10582260", "map_id": "none", "name": "Cytochrome P450 (CYP2E1 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10582265", "map_id": "none", "name": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_39427", "map_id": "CHEBI:46195", "name": "Acetaminophen (TN TYLENOL)", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_113555", "map_id": "CHEBI:18276", "name": "H2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_76396", "map_id": "CHEBI:29132", "name": "NABQI", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10582329", "map_id": "none", "name": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_40795", "map_id": "CHEBI:5615", "name": "HALO", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_76474", "map_id": "CHEBI:47266", "name": "HBr", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_76473", "map_id": "CHEBI:29138", "name": "TFAC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10582267", "map_id": "none", "name": "Benzene is hydroxylated to phenol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_31711", "map_id": "CHEBI:16716", "name": "C6H6", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_29630", "map_id": "CHEBI:15882", "name": "PhOH", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10582269", "map_id": "none", "name": "Dehalogenation of carbon tetrachloride to form a free radical", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_40887", "map_id": "CHEBI:27385", "name": "CCl4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_29572", "map_id": "CHEBI:17996", "name": "Cl-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_76433", "map_id": "none", "name": "Trichloromethyl radical", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10583662", "map_id": "none", "name": "MEOS oxidizes ethanol to acetaldehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_113748", "map_id": "CHEBI:16236", "name": "EtOH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_113745", "map_id": "CHEBI:15343", "name": "CH3CHO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10588874", "map_id": "none", "name": "Cyclophosphamide is 4-hydroxylated by CYP2B6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_211977", "map_id": "CHEBI:4026", "name": "CPM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_211967", "map_id": "CHEBI:1864", "name": "HCPM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10588796", "map_id": "none", "name": "Coumarin is 7-hydroxylated by CYP2A13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10588793", "map_id": "none", "name": "Cytochrome P450 (CYP2A13 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10588879", "map_id": "none", "name": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_211939", "map_id": "CHEBI:8107", "name": "Phenytoin", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_211927", "map_id": "CHEBI:63804", "name": "HPHT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10588876", "map_id": "none", "name": "Cytochrome P450 (CYP2C18 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10588791", "map_id": "none", "name": "CYP2S1 4-hydroxylates atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_215573", "map_id": "CHEBI:15367", "name": "atRA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_215584", "map_id": "CHEBI:63795", "name": "4OH-atRA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10582210", "map_id": "none", "name": "Homologues of CYP2S1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10588854", "map_id": "none", "name": "CYP2U1 19-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_216620", "map_id": "CHEBI:63998", "name": "19HETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10588862", "map_id": "none", "name": "CYP2W1 oxidises INDOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_216547", "map_id": "CHEBI:16881", "name": "INDOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_216598", "map_id": "CHEBI:31697", "name": "Oxindole", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10588859", "map_id": "none", "name": "Cytochrome P450 (CYP2W1 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10588867", "map_id": "none", "name": "CYP2J2 oxidises ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_215062", "map_id": "none", "name": "cis-EET", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10588864", "map_id": "none", "name": "Cytochrome P450 (CYP2J2 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10585571", "map_id": "none", "name": "UGTs transfer GlcA from UDP-GlcA to O-centre substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_174911", "map_id": "none", "name": "O-centre functional group substrate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "CHEBI:16580", "map_id": "CHEBI:16580", "name": "CHEBI:16580", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_174384", "map_id": "CHEBI:17200", "name": "UDP-GlcA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_158602", "map_id": "CHEBI:17659", "name": "UDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_174914", "map_id": "none", "name": "O-glucuronide", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "CHEBI:32649", "map_id": "CHEBI:32649", "name": "CHEBI:32649", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:65137", "map_id": "CHEBI:65137", "name": "CHEBI:65137", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:64681", "map_id": "CHEBI:64681", "name": "CHEBI:64681", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:32636", "map_id": "CHEBI:32636", "name": "CHEBI:32636", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10585568", "map_id": "none", "name": "UGTs (O-GlcA forming)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q54IL5", "map_id": "Q54IL5", "name": "ugt52", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288655", "map_id": "DDB_G0288655", "name": "ugt52", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FB2", "map_id": "Q55FB2", "name": "UGT1A6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268544", "map_id": "DDB_G0268544", "name": "UGT1A6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FX8", "map_id": "Q55FX8", "name": "UGT1A6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FY0", "map_id": "Q55FY0", "name": "UGT1A6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10626273", "map_id": "none", "name": "UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_159151", "map_id": "CHEBI:16990", "name": "BIL", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_159160", "map_id": "CHEBI:16427", "name": "BMG", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10585556", "map_id": "Q54IL5", "name": "ugt52", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10585554", "map_id": "none", "name": "Formation of N-glucuronides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_174932", "map_id": "none", "name": "N-centre functional group substrate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "CHEBI:17688", "map_id": "CHEBI:17688", "name": "CHEBI:17688", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_174918", "map_id": "none", "name": "N-glucuronide", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "CHEBI:63860", "map_id": "CHEBI:63860", "name": "CHEBI:63860", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:32663", "map_id": "CHEBI:32663", "name": "CHEBI:32663", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10585551", "map_id": "none", "name": "UGT1A3,A4,A9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10623226", "map_id": "none", "name": "UGT1A10 transfers GlcA from UDP-GlcA to GCTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8941723", "map_id": "CHEBI:34778", "name": "GCTN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_8941725", "map_id": "CHEBI:133667", "name": "GCTN4OG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10585549", "map_id": "none", "name": "Homologues of UGT1A9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10583800", "map_id": "none", "name": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_159149", "map_id": "CHEBI:18392", "name": "BDG", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10583797", "map_id": "none", "name": "Homologues of UGT1A4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10583802", "map_id": "none", "name": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "reaction_10626270", "map_id": "none", "name": "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10626267", "map_id": "none", "name": "UGT1A1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10611928", "map_id": "none", "name": "AS3MT transfers CH3 from AdoMet to methylarsonite", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5696224", "map_id": "CHEBI:14597", "name": "methylarsonite", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5696211", "map_id": "CHEBI:16223", "name": "dimethylarsinate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10611925", "map_id": "Q54MJ4", "name": "AS3MT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0285905", "map_id": "DDB_G0285905", "name": "AS3MT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10605451", "map_id": "none", "name": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605448", "map_id": "none", "name": "MAT2B:MAT2A:K+:2Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54VU3", "map_id": "Q54VU3", "name": "MAT2B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280135", "map_id": "DDB_G0280135", "name": "MAT2B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10611930", "map_id": "none", "name": "AS3MT transfers CH3 from AdoMet to arsenite(3-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5696216", "map_id": "CHEBI:29866", "name": "arsenite(3-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5696214", "map_id": "CHEBI:16005", "name": "methylarsonate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10616063", "map_id": "none", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6806829", "map_id": "CHEBI:17826", "name": "MMAIII", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6800127", "map_id": "CHEBI:48765", "name": "DMAA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10623867", "map_id": "none", "name": "IMPAD1 hydrolyses PAP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_8851226", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_8953493", "map_id": "CHEBI:16027", "name": "adenosine 5'-monophosphate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10623864", "map_id": "none", "name": "IMPAD1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_8953505", "map_id": "CHEBI:49713", "name": "Li+", "type": "inhibitor", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10585754", "map_id": "none", "name": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10585751", "map_id": "Q869K3", "name": "bpnt1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10597330", "map_id": "none", "name": "CNDP2:2Mn2+ dimer hydrolyses CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1247904", "map_id": "CHEBI:4047", "name": "CysGly", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10597327", "map_id": "none", "name": "CNDP2:2Mn2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54X02", "map_id": "Q54X02", "name": "CNDP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279291", "map_id": "DDB_G0279291", "name": "CNDP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10585509", "map_id": "none", "name": "GSS:Mg2+ dimer synthesizes GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_174393", "map_id": "CHEBI:17515", "name": "gGluCys", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10585506", "map_id": "none", "name": "GSS:Mg2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54E83", "map_id": "Q54E83", "name": "gshB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291756", "map_id": "DDB_G0291756", "name": "gshB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10612601", "map_id": "none", "name": "CHAC1,2 cleaves GSH to OPRO and CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1247942", "map_id": "CHEBI:18183", "name": "OPRO", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10612598", "map_id": "none", "name": "CHAC1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54LB6", "map_id": "Q54LB6", "name": "CHAC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286727", "map_id": "DDB_G0286727", "name": "CHAC2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10597340", "map_id": "none", "name": "OPLAH hydrolyses OPRO to L-Glu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10597337", "map_id": "none", "name": "OPLAH", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54NW6", "map_id": "Q54NW6", "name": "oplah", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284953", "map_id": "DDB_G0284953", "name": "oplah", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10611251", "map_id": "none", "name": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5692212", "map_id": "CHEBI:81626", "name": "BaPtDHD", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5692216", "map_id": "CHEBI:87752", "name": "BaP-7,8-dione", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10585698", "map_id": "none", "name": "GST dimers conjugate GSH with cytosolic substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176070", "map_id": "none", "name": "Electrophilic substrate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:34718", "map_id": "CHEBI:34718", "name": "CHEBI:34718", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:30614", "map_id": "CHEBI:30614", "name": "CHEBI:30614", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_176049", "map_id": "none", "name": "electrophilic substrate:SG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:8927", "map_id": "CHEBI:8927", "name": "CHEBI:8927", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:32639", "map_id": "CHEBI:32639", "name": "CHEBI:32639", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:34479", "map_id": "CHEBI:34479", "name": "CHEBI:34479", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10585695", "map_id": "none", "name": "GST dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54C73", "map_id": "Q54C73", "name": "GSTT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293122", "map_id": "DDB_G0293122", "name": "GSTT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JU2", "map_id": "Q54JU2", "name": "GSTT2B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287793", "map_id": "DDB_G0287793", "name": "GSTT2B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10611444", "map_id": "none", "name": "ESD dimer hydrolyses S-FGSH to GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_5693723", "map_id": "CHEBI:16225", "name": "S-FGSH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_158543", "map_id": "CHEBI:16856", "name": "GSH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_194712", "map_id": "CHEBI:30751", "name": "formate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10611441", "map_id": "none", "name": "ESD dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "Q54RL8", "map_id": "Q54RL8", "name": "ESD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283037", "map_id": "DDB_G0283037", "name": "ESD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10585708", "map_id": "none", "name": "GST trimers transfer GS from GSH to luminal substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_176065", "map_id": "none", "name": "electrophilic substrate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "CHEBI:27561", "map_id": "CHEBI:27561", "name": "CHEBI:27561", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_176048", "map_id": "none", "name": "electrophilic substrate:SG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "CHEBI:2505", "map_id": "CHEBI:2505", "name": "CHEBI:2505", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:35896", "map_id": "CHEBI:35896", "name": "CHEBI:35896", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10601760", "map_id": "none", "name": "COX10 transforms heme to heme O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_189444", "map_id": "CHEBI:17627", "name": "heme", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2995328", "map_id": "CHEBI:24480", "name": "heme O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10601757", "map_id": "Q54JB3", "name": "cox10", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0288169", "map_id": "DDB_G0288169", "name": "cox10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586066", "map_id": "none", "name": "ALAD condenses 2 dALAs to form PBG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_189489", "map_id": "CHEBI:356416", "name": "dALA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_189464", "map_id": "CHEBI:58126", "name": "PBG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10586063", "map_id": "none", "name": "8x(ALAD:Zn2+)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55E06", "map_id": "Q55E06", "name": "alad", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269444", "map_id": "DDB_G0269444", "name": "alad", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586084", "map_id": "none", "name": "ALAS condenses SUCC-CoA and Gly to form dALA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_189466", "map_id": "CHEBI:356416", "name": "dALA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10586081", "map_id": "none", "name": "ALAS1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54UX3", "map_id": "Q54UX3", "name": "hemA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280763", "map_id": "DDB_G0280763", "name": "hemA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586036", "map_id": "none", "name": "CPO transforms COPRO3 to PPGEN9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space" }, { "id": "species_189411", "map_id": "CHEBI:15439", "name": "COPRO3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_189480", "map_id": "CHEBI:16526", "name": "CO2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_189478", "map_id": "CHEBI:15435", "name": "PPGEN9", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10586033", "map_id": "none", "name": "2xCPO", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "Q54IA7", "map_id": "Q54IA7", "name": "cpox", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288893", "map_id": "DDB_G0288893", "name": "cpox", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586102", "map_id": "none", "name": "UROS transforms HMB to URO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_189449", "map_id": "CHEBI:57845", "name": "HMBL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_189407", "map_id": "CHEBI:15437", "name": "URO3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10586099", "map_id": "Q54NS4", "name": "hemD", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0285009", "map_id": "DDB_G0285009", "name": "hemD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586056", "map_id": "none", "name": "UROD decarboxylates URO3 to COPRO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_189455", "map_id": "CHEBI:15439", "name": "COPRO3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10586053", "map_id": "none", "name": "2xUROD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54DF9", "map_id": "Q54DF9", "name": "hemE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292294", "map_id": "DDB_G0292294", "name": "hemE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10601768", "map_id": "none", "name": "COX15 transforms heme O to heme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_2995348", "map_id": "CHEBI:24479", "name": "heme A", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10601765", "map_id": "O76740", "name": "coxA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0281549", "map_id": "DDB_G0281549", "name": "coxA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586106", "map_id": "none", "name": "ALAD binds to Pb2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_190173", "map_id": "CHEBI:27889", "name": "Pb2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10586104", "map_id": "none", "name": "8xALAD:Pb2+:Zn2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_391232", "map_id": "CHEBI:27889", "name": "Pb2+", "type": "inhibitor", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10586108", "map_id": "none", "name": "UROD decarboxylates URO1 to COPRO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_190157", "map_id": "CHEBI:28766", "name": "URO1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_190128", "map_id": "CHEBI:28607", "name": "COPRO1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10594876", "map_id": "none", "name": "ABCG2 tetramer transports heme from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_71185", "map_id": "CHEBI:17627", "name": "heme", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10594873", "map_id": "none", "name": "ABCG2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54T02", "map_id": "Q54T02", "name": "abcG24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282103", "map_id": "DDB_G0282103", "name": "abcG24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T686", "map_id": "Q8T686", "name": "abcG7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289655", "map_id": "DDB_G0289655", "name": "abcG7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T689", "map_id": "Q8T689", "name": "abcG4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289657", "map_id": "DDB_G0289657", "name": "abcG4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DA0", "map_id": "Q55DA0", "name": "abcG22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270826", "map_id": "DDB_G0270826", "name": "abcG22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DW4", "map_id": "Q55DW4", "name": "abcG1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269214", "map_id": "DDB_G0269214", "name": "abcG1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86HQ2", "map_id": "Q86HQ2", "name": "abcG8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274117", "map_id": "DDB_G0274117", "name": "abcG8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T685", "map_id": "Q8T685", "name": "abcG12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274115", "map_id": "DDB_G0274115", "name": "abcG12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586046", "map_id": "none", "name": "PPO oxidises PPGEN9 to PRIN9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space" }, { "id": "species_189463", "map_id": "CHEBI:15430", "name": "PRIN9", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10586043", "map_id": "none", "name": "2xPPOX:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "Q54DT8", "map_id": "Q54DT8", "name": "ppox", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292040", "map_id": "DDB_G0292040", "name": "ppox", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10586094", "map_id": "none", "name": "FECH binds Fe2+ to PRIN9 to form heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_189487", "map_id": "CHEBI:15430", "name": "PRIN9", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10586091", "map_id": "none", "name": "2x(FECH:2Fe-2S cluster)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54IA8", "map_id": "Q54IA8", "name": "hemH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288891", "map_id": "DDB_G0288891", "name": "hemH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10607713", "map_id": "none", "name": "ABCC2 transports BMG,BDG from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5679042", "map_id": "none", "name": "BMG,BDG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_5679034", "map_id": "none", "name": "BMG,BDG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10597695", "map_id": "none", "name": "Homologues of ABCC2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10627155", "map_id": "none", "name": "BIL dissociates from GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10627153", "map_id": "none", "name": "BIL:GSTA1, FABP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_189386", "map_id": "CHEBI:16990", "name": "BIL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10585603", "map_id": "none", "name": "Homologues of GSTA1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10627157", "map_id": "none", "name": "BIL binds GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10627151", "map_id": "none", "name": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10627148", "map_id": "none", "name": "ABCC1 transports BIL from cytosol to extracellular region (blood)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9661418", "map_id": "CHEBI:16990", "name": "BIL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10602853", "map_id": "none", "name": "HSBP1 binds HSF1 trimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10602818", "map_id": "none", "name": "HSF1 trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54UC1", "map_id": "Q54UC1", "name": "phospho-p-S303-HSF1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281165", "map_id": "DDB_G0281165", "name": "phospho-p-S303-HSF1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10602849", "map_id": "none", "name": "HSBP1 hexamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q556J3", "map_id": "Q556J3", "name": "HSBP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272620", "map_id": "DDB_G0272620", "name": "HSBP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10602851", "map_id": "none", "name": "HSBP1:HSF1 trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10605031", "map_id": "none", "name": "HSP90:FKBP4:PTGES3 binds HSF1 trimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10605027", "map_id": "none", "name": "HSP90:FKBP4:PTGES3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10605029", "map_id": "none", "name": "HSF1 trimer:HSP90:FKBP4:PTGES3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10592388", "map_id": "none", "name": "ZnT1 mediates the efflux of zinc from the cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_158417", "map_id": "CHEBI:29105", "name": "Zn2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10592385", "map_id": "Q54T06", "name": "SLC30A1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0282067", "map_id": "DDB_G0282067", "name": "SLC30A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10592414", "map_id": "none", "name": "PI3K alpha, beta, gamma convert PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10590600", "map_id": "none", "name": "PI3K gamma", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10581592", "map_id": "none", "name": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10581584", "map_id": "none", "name": "Homologues of p-T286-CCND1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10581590", "map_id": "none", "name": "Homologues of p-T286-CCND1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10581596", "map_id": "none", "name": "Proteasome mediated degradation of Cyclin D1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10581594", "map_id": "none", "name": "multi-ubiquitinated phospho-(T286) Cyclin D1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10622096", "map_id": "none", "name": "RAB5 GEFs exchange GTP for GDP on RAB5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_10622017", "map_id": "none", "name": "GGC-RAB5:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55FM7", "map_id": "Q55FM7", "name": "GDI2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268034", "map_id": "DDB_G0268034", "name": "GDI2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10621999", "map_id": "none", "name": "GDIs,CHMs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10622025", "map_id": "none", "name": "GGC-RAB5:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "species_10622093", "map_id": "none", "name": "RAB5 GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54NU1", "map_id": "Q54NU1", "name": "RIN2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291115", "map_id": "DDB_G0291115", "name": "RIN2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54W41", "map_id": "Q54W41", "name": "RIN2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VS5", "map_id": "Q54VS5", "name": "RIN2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AI4", "map_id": "Q55AI4", "name": "RIN2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AA6", "map_id": "Q55AA6", "name": "RIN2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54F48", "map_id": "Q54F48", "name": "RIN2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HF9", "map_id": "Q54HF9", "name": "RIN2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622352", "map_id": "none", "name": "DENND6A,B exchange GTP for GDP on RAB14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10622336", "map_id": "none", "name": "GGC-RAB14:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P36410", "map_id": "P36410", "name": "rab14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281337", "map_id": "DDB_G0281337", "name": "rab14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10622340", "map_id": "none", "name": "GGC-RAB14:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane", "complex": "true" }, { "id": "species_10622349", "map_id": "none", "name": "DENND6A,B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54VA9", "map_id": "Q54VA9", "name": "DENND6A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280481", "map_id": "DDB_G0280481", "name": "DENND6A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622528", "map_id": "none", "name": "RAB31 GEFs exchange GTP for GDP on RAB31", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_10622519", "map_id": "none", "name": "GGC-RAB31:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8MYF2", "map_id": "Q8MYF2", "name": "rabJ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277441", "map_id": "DDB_G0277441", "name": "rabJ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10622523", "map_id": "none", "name": "GGC-RAB31:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "species_10622525", "map_id": "none", "name": "RAB31 GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10622752", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10622739", "map_id": "none", "name": "GGC-RAB18:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10622743", "map_id": "none", "name": "GGC-RAB18:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10622749", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10622646", "map_id": "none", "name": "TRAPPC complexes exchange GTP for GDP on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13946", "compartment_display": "transport vesicle membrane" }, { "id": "species_10622591", "map_id": "none", "name": "GGC-RAB1:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10622619", "map_id": "none", "name": "GGC-RAB1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13946", "compartment_display": "transport vesicle membrane", "complex": "true" }, { "id": "species_10622643", "map_id": "none", "name": "TRAPPCs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54KR2", "map_id": "Q54KR2", "name": "TRAPPC11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287157", "map_id": "DDB_G0287157", "name": "TRAPPC11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54U24", "map_id": "Q54U24", "name": "TRAPPC12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281351", "map_id": "DDB_G0281351", "name": "TRAPPC12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55EX6", "map_id": "Q55EX6", "name": "TRAPPC13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269062", "map_id": "DDB_G0269062", "name": "TRAPPC13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CV2", "map_id": "Q54CV2", "name": "TRAPPC8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292682", "map_id": "DDB_G0292682", "name": "TRAPPC8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622583", "map_id": "none", "name": "MON1:CCZ1 exchanges GTP for GDP on RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10622534", "map_id": "none", "name": "GGC-RAB7:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10622564", "map_id": "none", "name": "GGC-RAB7:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10622580", "map_id": "none", "name": "MON1:CCZ1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54TG0", "map_id": "Q54TG0", "name": "MON1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281773", "map_id": "DDB_G0281773", "name": "MON1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IQ5", "map_id": "Q54IQ5", "name": "CCZ1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288589", "map_id": "DDB_G0288589", "name": "CCZ1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622247", "map_id": "none", "name": "RAB9 GEFs exchange GTP for GDP on RAB9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10622164", "map_id": "none", "name": "GGC-RAB9:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10622216", "map_id": "none", "name": "GGC-RAB9:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "species_10622244", "map_id": "none", "name": "RAB9 GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55DD7", "map_id": "Q55DD7", "name": "DENND2A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270918", "map_id": "DDB_G0270918", "name": "DENND2A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622260", "map_id": "none", "name": "RIC1-RGP1 exchanges GTP for GDP on RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10622251", "map_id": "none", "name": "GGC-RAB6:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10622257", "map_id": "none", "name": "GGC-RAB6:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10622709", "map_id": "none", "name": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane" }, { "id": "species_10622680", "map_id": "none", "name": "RAB32,RAB38:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10622694", "map_id": "none", "name": "RAB32,RAB38:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane", "complex": "true" }, { "id": "species_10622706", "map_id": "none", "name": "HPS1:HPS4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55FG6", "map_id": "Q55FG6", "name": "HPS4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268126", "map_id": "DDB_G0268126", "name": "HPS4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54M79", "map_id": "Q54M79", "name": "HPS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286137", "map_id": "DDB_G0286137", "name": "HPS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10622442", "map_id": "none", "name": "RAB21 GEFs exchange GTP for GDP on RAB21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_10622376", "map_id": "none", "name": "GGC-RAB21:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P34142", "map_id": "P34142", "name": "rab21", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286553", "map_id": "DDB_G0286553", "name": "rab21", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10622380", "map_id": "none", "name": "GGC-RAB21:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "species_10622439", "map_id": "none", "name": "RAB21 GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54PZ6", "map_id": "Q54PZ6", "name": "ANKRD27", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284213", "map_id": "DDB_G0284213", "name": "ANKRD27", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10624461", "map_id": "none", "name": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10624453", "map_id": "none", "name": "Mitochondrial targeting peptides (from inner membrane proteins)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54QH7", "map_id": "Q54QH7", "name": "NDUFB8(1-28)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283889", "map_id": "DDB_G0283889", "name": "NDUFB8(1-28)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10624458", "map_id": "Q8MP58", "name": "PITRM1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "DDB_G0271506", "map_id": "DDB_G0271506", "name": "PITRM1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10577280", "map_id": "none", "name": "Phosphorylated Cdc6 is exported from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10577255", "map_id": "Q552L8", "name": "phospho-p-CDC6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0275983", "map_id": "DDB_G0275983", "name": "CDC6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10577278", "map_id": "Q552L8", "name": "phospho-p-CDC6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10577387", "map_id": "none", "name": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10577284", "map_id": "none", "name": "ubiquitinated Cdc6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q552L8", "map_id": "Q552L8", "name": "CDC6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10577389", "map_id": "none", "name": "Ubiquitinated Cdc6 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10577276", "map_id": "none", "name": "Cdc6 protein is phosphorylated by CDK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10576515", "map_id": "Q552L8", "name": "CDC6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10577273", "map_id": "none", "name": "CCNA:p-T160-CDK2,CCNE:p-T160-CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10577393", "map_id": "none", "name": "Mcm4,6,7 trimer forms and associates with the replication fork", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10576576", "map_id": "none", "name": "MCM2-7", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54VI9", "map_id": "Q54VI9", "name": "MCM3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280309", "map_id": "DDB_G0280309", "name": "MCM3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86B14", "map_id": "Q86B14", "name": "mcm6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272760", "map_id": "DDB_G0272760", "name": "mcm6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RU0", "map_id": "Q54RU0", "name": "MCM7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282933", "map_id": "DDB_G0282933", "name": "MCM7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86IF1", "map_id": "Q86IF1", "name": "MCM4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275623", "map_id": "DDB_G0275623", "name": "MCM4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CP4", "map_id": "Q54CP4", "name": "mcm5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292958", "map_id": "DDB_G0292958", "name": "mcm5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LI2", "map_id": "Q54LI2", "name": "MCM2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286623", "map_id": "DDB_G0286623", "name": "MCM2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10576574", "map_id": "Q54LI2", "name": "MCM2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10577391", "map_id": "none", "name": "Mcm4,6,7 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10576559", "map_id": "Q54CP4", "name": "mcm5", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10576549", "map_id": "Q54VI9", "name": "MCM3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10576897", "map_id": "none", "name": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10576678", "map_id": "Q54RM2", "name": "phospho-orcA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10576868", "map_id": "Q54RM2", "name": "phospho-orcA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10576894", "map_id": "none", "name": "SCF (SKP2) complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10576901", "map_id": "none", "name": "Ubiquitinated Orc1 enters the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10576899", "map_id": "Q54RM2", "name": "phospho-orcA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10576708", "map_id": "none", "name": "Orc1 is phosphorylated by cyclin A/CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10576578", "map_id": "none", "name": "pre-replicative complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54RN8", "map_id": "Q54RN8", "name": "MCM8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283009", "map_id": "DDB_G0283009", "name": "MCM8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10576680", "map_id": "none", "name": "pre-replicative complex (Orc1-minus)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10577243", "map_id": "none", "name": "Ubiquitinated Orc1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10585789", "map_id": "none", "name": "Formation of GINS complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10585775", "map_id": "Q54BL9", "name": "gins2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0293564", "map_id": "DDB_G0293564", "name": "gins2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10585770", "map_id": "Q54HR6", "name": "gins1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0289271", "map_id": "DDB_G0289271", "name": "gins1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10585785", "map_id": "Q55EA2", "name": "gins4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0269324", "map_id": "DDB_G0269324", "name": "gins4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10585780", "map_id": "Q54EH6", "name": "gins3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0291506", "map_id": "DDB_G0291506", "name": "gins3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10585787", "map_id": "none", "name": "GINS complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54EH6", "map_id": "Q54EH6", "name": "gins3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55EA2", "map_id": "Q55EA2", "name": "gins4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HR6", "map_id": "Q54HR6", "name": "gins1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BL9", "map_id": "Q54BL9", "name": "gins2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10577248", "map_id": "none", "name": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10576632", "map_id": "none", "name": "RNA primer:origin duplex:DNA polymerase alpha:primase complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10576604", "map_id": "none", "name": "DNA polymerase alpha:primase", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10576635", "map_id": "none", "name": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10576630", "map_id": "none", "name": "DNA polymerase alpha:primase:DNA polymerase alpha:origin complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54RD4", "map_id": "Q54RD4", "name": "pole", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283189", "map_id": "DDB_G0283189", "name": "pole", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KWN0", "map_id": "Q7KWN0", "name": "POLE4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272740", "map_id": "DDB_G0272740", "name": "POLE4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Y85", "map_id": "Q54Y85", "name": "pole2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278367", "map_id": "DDB_G0278367", "name": "pole2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q75JQ9", "map_id": "Q75JQ9", "name": "pole3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272222", "map_id": "DDB_G0272222", "name": "pole3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10576626", "map_id": "none", "name": "DNA polymerase epsilon", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10576580", "map_id": "none", "name": "Mcm2-7 associates with the Cdt1:CDC6:ORC:origin complex, forming the pre-replicative complex (preRC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10576544", "map_id": "none", "name": "CDT1:CDC6:ORC:origin complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10585791", "map_id": "none", "name": "Association of MCM8 with ORC:origin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10576532", "map_id": "Q54RN8", "name": "MCM8", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10576536", "map_id": "none", "name": "ORC:origin of replication", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10576540", "map_id": "none", "name": "CDC6 association with ORC:origin complexes mediated by MCM8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10576538", "map_id": "none", "name": "CDC6:ORC:origin complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10576526", "map_id": "none", "name": "CDC6 protein is synthesized under the control of E2F transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10576524", "map_id": "none", "name": "E2F1/2/3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10576672", "map_id": "none", "name": "Cdc45 associates with the pre-replicative complex at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10576668", "map_id": "none", "name": "CDK:DDK:MCM10:active pre-replicative complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54DK3", "map_id": "Q54DK3", "name": "cdc7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292152", "map_id": "DDB_G0292152", "name": "cdc7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10576642", "map_id": "Q55GA4", "name": "cdc45", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0267748", "map_id": "DDB_G0267748", "name": "cdc45", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10576670", "map_id": "none", "name": "CDK:DDK:MCM10:active pre-replicative complex:CDC45", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55GA4", "map_id": "Q55GA4", "name": "cdc45", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10577252", "map_id": "none", "name": "DNA polymerase epsilon binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_68419", "map_id": "none", "name": "origin of replication", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10576628", "map_id": "none", "name": "DNA polymerase epsilon:origin complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10576637", "map_id": "none", "name": "DNA polymerase alpha:primase binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10589187", "map_id": "none", "name": "Association of HMGB1/HMGB2 with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_29428", "map_id": "none", "name": "DNA", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10589185", "map_id": "none", "name": "HMGB1/HMGB2- bound chromatin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10589444", "map_id": "none", "name": "Mitochondrial recruitment of Drp1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10589436", "map_id": "none", "name": "Homologues of DNM1L", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q94464", "map_id": "Q94464", "name": "dymA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277849", "map_id": "DDB_G0277849", "name": "dymA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U1M9", "map_id": "Q9U1M9", "name": "dymB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277851", "map_id": "DDB_G0277851", "name": "dymB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10589442", "map_id": "none", "name": "Homologues of DNM1L", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "species_10589400", "map_id": "Q54K74", "name": "BCAP31(2-164)", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0287543", "map_id": "DDB_G0287543", "name": "BCAP31(2-164)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10589430", "map_id": "none", "name": "Nuclear translocation of catalytic domain of Mst3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10589416", "map_id": "none", "name": "Homologues of STK24(1-313)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O61122", "map_id": "O61122", "name": "svkA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286359", "map_id": "DDB_G0286359", "name": "svkA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DC8", "map_id": "Q54DC8", "name": "STK24(1-313)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292350", "map_id": "DDB_G0292350", "name": "STK24(1-313)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10589428", "map_id": "none", "name": "Homologues of STK24(1-313)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10601347", "map_id": "none", "name": "CK2 phosphorylates condensin I subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10601313", "map_id": "none", "name": "Condensin I", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54B17", "map_id": "Q54B17", "name": "phospho-p-S-NCAPD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293984", "map_id": "DDB_G0293984", "name": "phospho-p-S-NCAPD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DR4", "map_id": "Q54DR4", "name": "phospho-p-S570-NCAPH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292066", "map_id": "DDB_G0292066", "name": "phospho-p-S570-NCAPH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WY1", "map_id": "Q54WY1", "name": "phospho-p-S-NCAPG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279329", "map_id": "DDB_G0279329", "name": "phospho-p-S-NCAPG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10601303", "map_id": "none", "name": "CK2 Phosphorylated Condensin I", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10601315", "map_id": "none", "name": "Dephosphorylation of CK2-modified condensin I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2529006", "map_id": "none", "name": "Unknown Phosphatase", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10605458", "map_id": "none", "name": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10605455", "map_id": "none", "name": "adenylate cyclases:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10605510", "map_id": "none", "name": "KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5263228", "compartment_display": "ciliary tip" }, { "id": "species_10605506", "map_id": "Q6S003", "name": "kif8", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5263228", "compartment_display": "ciliary tip", "complex": "false" }, { "id": "DDB_G0284471", "map_id": "DDB_G0284471", "name": "kif8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10605504", "map_id": "none", "name": "microtubule", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18728", "compartment_display": "axonemal microtubule", "complex": "true" }, { "id": "species_10605508", "map_id": "none", "name": "KIF7:microtubule", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5263228", "compartment_display": "ciliary tip", "complex": "true" }, { "id": "Q6S003", "map_id": "Q6S003", "name": "kif8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10605534", "map_id": "none", "name": "cAMP dissociates PKA, promoting GLI processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5263232", "compartment_display": "ciliary base" }, { "id": "species_10605530", "map_id": "none", "name": "PKA tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5263232", "compartment_display": "ciliary base", "complex": "true" }, { "id": "species_10605518", "map_id": "none", "name": "Homologues of PRKACA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5263232", "compartment_display": "ciliary base", "complex": "true" }, { "id": "species_10605532", "map_id": "none", "name": "PKA regulatory subunits:cAMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5263232", "compartment_display": "ciliary base", "complex": "true" }, { "id": "reaction_10580620", "map_id": "none", "name": "Binding of RRN3 to RNA Polymerase I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10580616", "map_id": "Q54HB0", "name": "RRN3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0289587", "map_id": "DDB_G0289587", "name": "RRN3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10580611", "map_id": "none", "name": "RNA Polymerase I Holoenzyme", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54YF5", "map_id": "Q54YF5", "name": "rpa12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278263", "map_id": "DDB_G0278263", "name": "rpa12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BM1", "map_id": "Q54BM1", "name": "polr1b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293560", "map_id": "DDB_G0293560", "name": "polr1b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SN4", "map_id": "Q54SN4", "name": "polr1c", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282339", "map_id": "DDB_G0282339", "name": "polr1c", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86H36", "map_id": "Q86H36", "name": "polr1a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275759", "map_id": "DDB_G0275759", "name": "polr1a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FE8", "map_id": "Q54FE8", "name": "polr1e", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290909", "map_id": "DDB_G0290909", "name": "polr1e", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FA4", "map_id": "Q55FA4", "name": "rpa43", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268198", "map_id": "DDB_G0268198", "name": "rpa43", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10580618", "map_id": "none", "name": "Active RNA Polymerase I", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54HB0", "map_id": "Q54HB0", "name": "RRN3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10581489", "map_id": "none", "name": "Elongation of pre-rRNA transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_350", "compartment_display": "nucleolus" }, { "id": "species_74985", "map_id": "none", "name": "elongating pre-rRNA transcript", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10580705", "map_id": "none", "name": "RNA Polymerase I promoter escape complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q554V6", "map_id": "Q554V6", "name": "Ac-TAF1B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274953", "map_id": "DDB_G0274953", "name": "Ac-TAF1B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10581487", "map_id": "none", "name": "Chromatin (H3K9me2):CBX3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55C69", "map_id": "Q55C69", "name": "hcpC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270198", "map_id": "DDB_G0270198", "name": "hcpC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RN0", "map_id": "Q54RN0", "name": "CBX5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283023", "map_id": "DDB_G0283023", "name": "CBX5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RQ4", "map_id": "Q54RQ4", "name": "CBX5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10580707", "map_id": "none", "name": "Loss of Rrn3 from RNA Polymerase I promoter escape complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10580701", "map_id": "none", "name": "RNA Polymerase I Transcription Initiation complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10590390", "map_id": "none", "name": "Activation of PAKs by RAC1 and CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10590384", "map_id": "none", "name": "PAK1,2,3 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10590388", "map_id": "none", "name": "PAK1,2,3:CDC42:GTP, RAC1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10590386", "map_id": "none", "name": "PAK1,2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10592081", "map_id": "none", "name": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10592069", "map_id": "none", "name": "AQP2 tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13946", "compartment_display": "transport vesicle membrane", "complex": "true" }, { "id": "Q54FQ9", "map_id": "Q54FQ9", "name": "MIP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290691", "map_id": "DDB_G0290691", "name": "MIP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54V53", "map_id": "Q54V53", "name": "wacA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280537", "map_id": "DDB_G0280537", "name": "wacA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10592079", "map_id": "none", "name": "p-S256-AQP2 tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13946", "compartment_display": "transport vesicle membrane", "complex": "true" }, { "id": "reaction_10592022", "map_id": "none", "name": "Aquaporin-1 passively transports water into cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10592024", "map_id": "none", "name": "Aquaporin-1 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10592059", "map_id": "none", "name": "Aquaporin-4 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10592056", "map_id": "none", "name": "AQP4 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10592046", "map_id": "none", "name": "p-S256-Aquaporin-2 passively transports water into cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10592043", "map_id": "none", "name": "p-S256-AQP2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10625623", "map_id": "none", "name": "p-S216-CDC25C translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10581495", "map_id": "Q54QM6", "name": "phospho-cdc25", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10581499", "map_id": "Q54QM6", "name": "phospho-cdc25", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10581576", "map_id": "none", "name": "Phosphorylation of Cdc25C at Ser216 by CHEK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10608080", "map_id": "none", "name": "p-T68-CHEK2 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10608076", "map_id": "Q54VI1", "name": "phospho-fhkE", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10608078", "map_id": "none", "name": "p-T68-CHEK2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54VI1", "map_id": "Q54VI1", "name": "phospho-fhkE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10608083", "map_id": "none", "name": "p-T68-CHEK2 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10581497", "map_id": "none", "name": "Phosphorylation of Cdc25C at Ser 216 by Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10601585", "map_id": "none", "name": "Activation of Calcineurin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10599837", "map_id": "none", "name": "Calcineurin (CaN)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55G87", "map_id": "Q55G87", "name": "cnbA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267446", "map_id": "DDB_G0267446", "name": "cnbA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7YSW8", "map_id": "Q7YSW8", "name": "canA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276883", "map_id": "DDB_G0276883", "name": "canA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:29034", "map_id": "CHEBI:29034", "name": "CHEBI:29034", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10601542", "map_id": "none", "name": "Calcineurin:Calmodulin (CaN:CaM)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10601566", "map_id": "none", "name": "Translocation of CaN:CaM:NFAT to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10601546", "map_id": "none", "name": "NFAT:CaN:CaM", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10601564", "map_id": "none", "name": "NFAT:CaN:CaM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10605809", "map_id": "none", "name": "RAF1 binds p21 RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10590651", "map_id": "Q54TM7", "name": "drkD", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0281557", "map_id": "DDB_G0281557", "name": "phospho-drkD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10605804", "map_id": "none", "name": "p21 RAS:GTP:RAF1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54TM7", "map_id": "Q54TM7", "name": "phospho-drkD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10605807", "map_id": "none", "name": "PAK phosphorylates p21 RAF1 on S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10605796", "map_id": "none", "name": "p21 RAS:GTP:p-S338-RAF1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10605769", "map_id": "none", "name": "HDAC6 deacetylates microtubules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605766", "map_id": "none", "name": "acetylated microtubule", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10605033", "map_id": "Q54X15", "name": "hdaD", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10608705", "map_id": "none", "name": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10608691", "map_id": "none", "name": "Ack-ACCS2,AcK-GLUD,AcK-IDH2,Ack-SOD2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54Z60", "map_id": "Q54Z60", "name": "acsA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5688337", "map_id": "CHEBI:76279", "name": "2'-O-acetyl-ADP-ribose", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10608695", "map_id": "none", "name": "ACCS2,GLUD,IDH2,SOD2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_5688274", "map_id": "CHEBI:17154", "name": "NAM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10608702", "map_id": "none", "name": "SIRT3(?-399):Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q54LF0", "map_id": "Q54LF0", "name": "sir2B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286671", "map_id": "DDB_G0286671", "name": "sir2B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10608718", "map_id": "none", "name": "SIRT5 deacetylates Cytochrome C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space" }, { "id": "species_5688282", "map_id": "CHEBI:57540", "name": "NAD+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10608708", "map_id": "Q869N1", "name": "cytC", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_5688281", "map_id": "CHEBI:17154", "name": "NAM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_5688340", "map_id": "CHEBI:76279", "name": "2'-O-acetyl-ADP-ribose", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10608715", "map_id": "none", "name": "SIRT5:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "Q55DB0", "map_id": "Q55DB0", "name": "sir2E", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270928", "map_id": "DDB_G0270928", "name": "sir2E", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10624307", "map_id": "none", "name": "Active G alpha (i)i1/i2/i3 binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10584927", "map_id": "none", "name": "G alpha (i): GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10624289", "map_id": "none", "name": "RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10624305", "map_id": "none", "name": "G alpha (i):GTP:RGS", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10585810", "map_id": "none", "name": "PKA phosphorylates PDE4B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10585799", "map_id": "none", "name": "Homologues of PDE4B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10585807", "map_id": "none", "name": "Homologues of p-S54-PDE4B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10626513", "map_id": "none", "name": "p-S54-PDE4B hydrolyses cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10583101", "map_id": "none", "name": "PDE4A,C,D hydrolyse cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10583098", "map_id": "none", "name": "PDE4A,C,D", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10584502", "map_id": "none", "name": "G-protein alpha subunit is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_947587", "compartment_display": "cytoplasmic side of plasma membrane" }, { "id": "species_10582951", "map_id": "none", "name": "G-protein alpha (q/11/14/15)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10584945", "map_id": "none", "name": "Galpha-olf:GTP binds to adenylate cyclase and activates it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10584942", "map_id": "none", "name": "G alpha-olf:GTP:Adenylate cyclase (active) complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10584961", "map_id": "none", "name": "Adenylaye cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10584956", "map_id": "none", "name": "G alpha-olf:GDP:Adenylate cyclase (active) complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10584954", "map_id": "none", "name": "Adenylate cyclase converts ATP into cyclic AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10584958", "map_id": "none", "name": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10589829", "map_id": "none", "name": "Liganded Gi-activating GPCR acts as a GEF for Gi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_947587", "compartment_display": "cytoplasmic side of plasma membrane" }, { "id": "species_10589822", "map_id": "none", "name": "Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10589826", "map_id": "none", "name": "Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10624310", "map_id": "none", "name": "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10624291", "map_id": "none", "name": "G alpha (i):GDP:RGS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10624293", "map_id": "none", "name": "G alpha (i):RGS dissociates to inactive G alpha (i)i1/i2/i3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10601449", "map_id": "none", "name": "Slo3 Potassium Transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10601446", "map_id": "none", "name": "Slo3 Channel", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q55CU6", "map_id": "Q55CU6", "name": "KCNU1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269896", "map_id": "DDB_G0269896", "name": "KCNU1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SN1", "map_id": "Q54SN1", "name": "potA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282291", "map_id": "DDB_G0282291", "name": "potA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10583314", "map_id": "none", "name": "DSIF complex binds to RNA Pol II (hypophosphorylated)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10583215", "map_id": "none", "name": "RNA Pol II (hypophosphorylated):capped pre-mRNA complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10583165", "map_id": "none", "name": "DSIF complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10583217", "map_id": "none", "name": "RNA Pol II (hypophosphorylated) complex bound to DSIF protein", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10583222", "map_id": "none", "name": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10583170", "map_id": "Q75JA4", "name": "CTDP1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10578883", "map_id": "none", "name": "capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10583320", "map_id": "none", "name": "Pol II elongation complex moves on the template as transcript elongates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10583290", "map_id": "none", "name": "Processive elongation complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55F33", "map_id": "Q55F33", "name": "MLLT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268922", "map_id": "DDB_G0268922", "name": "MLLT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q555G9", "map_id": "Q555G9", "name": "cdc73", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274885", "map_id": "DDB_G0274885", "name": "cdc73", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55E33", "map_id": "Q55E33", "name": "PAF1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269412", "map_id": "DDB_G0269412", "name": "PAF1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LP1", "map_id": "Q54LP1", "name": "RTF1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286523", "map_id": "DDB_G0286523", "name": "RTF1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Y92", "map_id": "Q54Y92", "name": "DG1071", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277841", "map_id": "DDB_G0277841", "name": "DG1071", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MB8", "map_id": "Q54MB8", "name": "leo1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286051", "map_id": "DDB_G0286051", "name": "leo1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86A81", "map_id": "Q86A81", "name": "IWS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274327", "map_id": "DDB_G0274327", "name": "IWS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55A48", "map_id": "Q55A48", "name": "SUPT6H", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272354", "map_id": "DDB_G0272354", "name": "SUPT6H", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10583302", "map_id": "none", "name": "Elongation complex prior to separation", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10583306", "map_id": "none", "name": "Separation of elongating transcript from template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10583304", "map_id": "none", "name": "Elongation complex with separated and uncleaved transcript", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10583292", "map_id": "none", "name": "Addition of nucleotides leads to transcript elongation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10583288", "map_id": "none", "name": "Elongation complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10583692", "map_id": "none", "name": "PLK1 phosphorylates NUDC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10583686", "map_id": "Q54M64", "name": "nudc", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0286159", "map_id": "DDB_G0286159", "name": "nudc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10583690", "map_id": "Q54M64", "name": "phospho-nudc", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10583678", "map_id": "Q86HN7", "name": "phospho-PLK", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10601043", "map_id": "none", "name": "Phosphorylation of cohesin by PLK1 at chromosomal arms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1598585", "compartment_display": "chromosome" }, { "id": "species_10601028", "map_id": "none", "name": "Sister Chromosomal Arms:Ac-Cohesin:PDS5:p-CDCA5:WAPAL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1598585", "compartment_display": "chromosome", "complex": "true" }, { "id": "species_10601040", "map_id": "none", "name": "Sister Chromosomal Arms:p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1598585", "compartment_display": "chromosome", "complex": "true" }, { "id": "species_10585345", "map_id": "Q86HN7", "name": "PLK", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10589619", "map_id": "none", "name": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_375409", "map_id": "none", "name": "Gly, L-Pro", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_375414", "map_id": "none", "name": "Gly, L-Pro", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10589616", "map_id": "Q54CB3", "name": "SLC36A2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10589624", "map_id": "none", "name": "SLC36A1-mediated uptake of glycine, proline, and alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_375400", "map_id": "none", "name": "ligands of SLC36A1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_375411", "map_id": "none", "name": "ligands of SLC36A1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10589621", "map_id": "Q54CB3", "name": "SLC36A1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10581901", "map_id": "none", "name": "Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10581835", "map_id": "none", "name": "TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q8T1F9", "map_id": "Q8T1F9", "name": "GTF3C6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275127", "map_id": "DDB_G0275127", "name": "GTF3C6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GS8", "map_id": "Q54GS8", "name": "gtf3c5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289935", "map_id": "DDB_G0289935", "name": "gtf3c5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WL4", "map_id": "Q54WL4", "name": "GTF3C2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279565", "map_id": "DDB_G0279565", "name": "GTF3C2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YB5", "map_id": "Q54YB5", "name": "TFIIIC3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278321", "map_id": "DDB_G0278321", "name": "TFIIIC3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FU1", "map_id": "Q54FU1", "name": "GTF3C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290591", "map_id": "DDB_G0290591", "name": "GTF3C1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54U85", "map_id": "Q54U85", "name": "TFIIIB2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281215", "map_id": "DDB_G0281215", "name": "TFIIIB2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54R53", "map_id": "Q54R53", "name": "TFIIIB1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283405", "map_id": "DDB_G0283405", "name": "TFIIIB1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10581897", "map_id": "none", "name": "RNA Polymerase III Holoenzyme", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q557J3", "map_id": "Q557J3", "name": "polr3h-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273425", "map_id": "DDB_G0273425", "name": "polr3h-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LP2", "map_id": "Q54LP2", "name": "rpc9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286521", "map_id": "DDB_G0286521", "name": "rpc9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IM0", "map_id": "Q54IM0", "name": "POLR3GL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288665", "map_id": "DDB_G0288665", "name": "POLR3GL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FJ5", "map_id": "Q55FJ5", "name": "polr3c", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268080", "map_id": "DDB_G0268080", "name": "polr3c", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86JM3", "map_id": "Q86JM3", "name": "polr3f", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272022", "map_id": "DDB_G0272022", "name": "polr3f", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54K02", "map_id": "Q54K02", "name": "rpc11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287707", "map_id": "DDB_G0287707", "name": "rpc11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T1V7", "map_id": "Q8T1V7", "name": "polr3d", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277671", "map_id": "DDB_G0277671", "name": "polr3d", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86JI9", "map_id": "Q86JI9", "name": "rpc5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271514", "map_id": "DDB_G0271514", "name": "rpc5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86AQ5", "map_id": "Q86AQ5", "name": "polr3a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277199", "map_id": "DDB_G0277199", "name": "polr3a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IZ9", "map_id": "Q54IZ9", "name": "polr3b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288449", "map_id": "DDB_G0288449", "name": "polr3b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10581899", "map_id": "none", "name": "RNA polymerase III:TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10627075", "map_id": "none", "name": "Dual mechanism MAP2K inhibitors bind MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9657567", "map_id": "none", "name": "dual mechanism MAP2K1/2 inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10607239", "map_id": "none", "name": "activated RAF:scaffold:MAP2K:MAPK complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54VC0", "map_id": "Q54VC0", "name": "phospho-p-S311,S406 KSR1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282895", "map_id": "DDB_G0282895", "name": "phospho-p-S311,S406 KSR1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WS5", "map_id": "Q54WS5", "name": "phospho-roco6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279417", "map_id": "DDB_G0279417", "name": "phospho-roco6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXD6", "map_id": "Q1ZXD6", "name": "phospho-roco5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0294533", "map_id": "DDB_G0294533", "name": "phospho-roco5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q869X3", "map_id": "Q869X3", "name": "phospho-p-S311,S406 KSR1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23915", "map_id": "Q23915", "name": "phospho-kinX", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283391", "map_id": "DDB_G0283391", "name": "phospho-kinX", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GY6", "map_id": "Q54GY6", "name": "phospho-kxcA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289859", "map_id": "DDB_G0289859", "name": "phospho-kxcA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54H05", "map_id": "Q54H05", "name": "phospho-kinY", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289661", "map_id": "DDB_G0289661", "name": "phospho-kinY", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RZ7", "map_id": "Q54RZ7", "name": "phospho-p-S311,S406 KSR1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TH6", "map_id": "Q54TH6", "name": "phospho-p-S311,S406 KSR1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TA3", "map_id": "Q54TA3", "name": "mrkC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281895", "map_id": "DDB_G0281895", "name": "mrkC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VU4", "map_id": "Q54VU4", "name": "MARK3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280133", "map_id": "DDB_G0280133", "name": "MARK3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FV4", "map_id": "Q55FV4", "name": "fnkB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267934", "map_id": "DDB_G0267934", "name": "fnkB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DF2", "map_id": "Q54DF2", "name": "mrkA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292304", "map_id": "DDB_G0292304", "name": "mrkA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10607241", "map_id": "none", "name": "activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10607298", "map_id": "none", "name": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10607294", "map_id": "none", "name": "WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "Q54H44", "map_id": "Q54H44", "name": "morg1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289711", "map_id": "DDB_G0289711", "name": "morg1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10607296", "map_id": "none", "name": "WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10607253", "map_id": "none", "name": "RAF phosphorylates MAP2K dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10607230", "map_id": "none", "name": "activated RAF:scaffold:p-2S MAP2K:MAPK complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10607251", "map_id": "none", "name": "p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10627079", "map_id": "none", "name": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9657574", "map_id": "none", "name": "single mechanism MAP2K1/2 inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10607237", "map_id": "none", "name": "activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10627077", "map_id": "none", "name": "Dual mechanism MAPK inhibitors bind MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9657570", "map_id": "none", "name": "dual mechanism MAPK inhibitors", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10607243", "map_id": "none", "name": "activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10627083", "map_id": "none", "name": "Single mechanism MAPK inhibitors bind phosphorylated MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9657577", "map_id": "none", "name": "single mechanism MAPK inhibitors", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10607234", "map_id": "none", "name": "activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10627081", "map_id": "none", "name": "activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10607245", "map_id": "none", "name": "MAP2Ks phosphorylate MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10602533", "map_id": "none", "name": "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10602093", "map_id": "none", "name": "Histone H3", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10602506", "map_id": "none", "name": "AcK15-histone H3", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10602530", "map_id": "none", "name": "KAT6:ING5:MEAF6:BRPF1,(2,3)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10602468", "map_id": "none", "name": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10600607", "map_id": "Q54F38", "name": "H3v1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10602427", "map_id": "Q54F38", "name": "H3v1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10602465", "map_id": "none", "name": "KAT7:ING4,5 dimers:MEAF6:PHF17,(15,16)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10602922", "map_id": "none", "name": "Type B histone acetlytransferase complex acetylates histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10602900", "map_id": "Q76NW2", "name": "H4b", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10602919", "map_id": "none", "name": "HAT1:RBBP7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q86J12", "map_id": "Q86J12", "name": "HAT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274269", "map_id": "DDB_G0274269", "name": "HAT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10606579", "map_id": "none", "name": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10606223", "map_id": "none", "name": "Me3K28-histone H3", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10604220", "map_id": "none", "name": "Me2K28-histone H3", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10604227", "map_id": "O77033", "name": "trfA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0269194", "map_id": "DDB_G0269194", "name": "trfA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10604197", "map_id": "none", "name": "JMJD6 demethylates MeR3-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10602206", "map_id": "none", "name": "MeR3-histone H3", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10604194", "map_id": "O97101", "name": "cbfA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0279409", "map_id": "DDB_G0279409", "name": "cbfA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10606581", "map_id": "none", "name": "JMJD6 demethylates Me2R3-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604669", "map_id": "none", "name": "Me2aR3-histone H3", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10604215", "map_id": "none", "name": "KDM5A-D demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604199", "map_id": "none", "name": "Me2K5-histone H3", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10602091", "map_id": "none", "name": "MeK5-histone H3", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10604212", "map_id": "none", "name": "KDM5A-D", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55ER4", "map_id": "Q55ER4", "name": "KDM5D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268778", "map_id": "DDB_G0268778", "name": "KDM5D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10606583", "map_id": "none", "name": "JMJD6 demethylates MeR4-HIST1H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604614", "map_id": "Q76NW2", "name": "H4b", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10606585", "map_id": "none", "name": "JMJD6 demethylates Me2sR4-HIST1H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604678", "map_id": "Q76NW2", "name": "H4b", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10604232", "map_id": "none", "name": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604225", "map_id": "none", "name": "MeK28-histone H3", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10606572", "map_id": "none", "name": "KDM5A-D demethylate Me3K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604902", "map_id": "none", "name": "Me3K5-histone H3", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10627346", "map_id": "none", "name": "HDAC1:2-containing complex binds HDAC2 Inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10603176", "map_id": "none", "name": "Sin3A complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54LI3", "map_id": "Q54LI3", "name": "BRMS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286805", "map_id": "DDB_G0286805", "name": "BRMS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QG3", "map_id": "Q54QG3", "name": "SAP30", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283845", "map_id": "DDB_G0283845", "name": "SAP30", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NX4", "map_id": "Q54NX4", "name": "SAP18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285057", "map_id": "DDB_G0285057", "name": "SAP18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_9679795", "map_id": "none", "name": "HDAC2 inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10603179", "map_id": "none", "name": "HDAC1:2-containing complex:HDAC2 inhibitors", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10603206", "map_id": "none", "name": "HDAC10 deacetylates histone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10603132", "map_id": "none", "name": "Acetylated core histone octamer", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10603138", "map_id": "none", "name": "Core histone octamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_5566518", "map_id": "CHEBI:30089", "name": "acetate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10603203", "map_id": "none", "name": "Homologues of HDAC10", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10603181", "map_id": "none", "name": "HDAC1:2-containing complex deacetylate histones", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10604673", "map_id": "none", "name": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604664", "map_id": "none", "name": "MeR3-histone H3, Histone H3", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10604671", "map_id": "none", "name": "Me2aR3-histone H3, MeR3-histone H3", "type": "inhibitor", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10604619", "map_id": "Q54HI0", "name": "prmt2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10604624", "map_id": "none", "name": "PRMT1,PRMT6 methylate arginine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604621", "map_id": "none", "name": "PRMT1,PRMT6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54EF2", "map_id": "Q54EF2", "name": "prmt1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291556", "map_id": "DDB_G0291556", "name": "prmt1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10604709", "map_id": "none", "name": "PRMT1 methylates arginine-12 of histone H2A (H2AR11)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604693", "map_id": "none", "name": "MeR12-histone H2A, Histone H2A", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10604706", "map_id": "none", "name": "Me2aR12-histone H2A, MeR12-histone H2A", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10602098", "map_id": "Q54EF2", "name": "prmt1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10604900", "map_id": "none", "name": "PRMT6 methylates histone H2A arginine-30 (H2AR29)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604885", "map_id": "none", "name": "MeR30-histone H2A, Histone H2A", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10604898", "map_id": "none", "name": "Me2aR30-histone H2A, MeR30-histone H2A", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10604791", "map_id": "none", "name": "WDR5 binds Me2sR3-replicative histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604420", "map_id": "none", "name": "Homologues of WDR5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10604769", "map_id": "none", "name": "Me2sR3-histone H3", "type": "inhibitor", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10604789", "map_id": "none", "name": "WDR5:Me2sR3-histone H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10604795", "map_id": "none", "name": "RBBP7 binds histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10602917", "map_id": "none", "name": "Homologues of RBBP7", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10604793", "map_id": "none", "name": "RBBP7:Replicative histone H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10604653", "map_id": "none", "name": "PRMT6 methylates arginine-4 of histone H2A (H2AR3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604637", "map_id": "none", "name": "MeR4-histone H2A, Histone H2A", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10604650", "map_id": "none", "name": "Me2aR4-histone H2A, MeR4-histone H2A", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10606590", "map_id": "none", "name": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10606588", "map_id": "Q76NW2", "name": "H4b", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10606145", "map_id": "none", "name": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10606142", "map_id": "none", "name": "WHSC1L1, Core MLL complex, SMYD3, SETD3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54HS3", "map_id": "Q54HS3", "name": "set1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289257", "map_id": "DDB_G0289257", "name": "set1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AQ4", "map_id": "Q55AQ4", "name": "ASH2L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271754", "map_id": "DDB_G0271754", "name": "ASH2L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IV4", "map_id": "Q54IV4", "name": "SMYD3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288495", "map_id": "DDB_G0288495", "name": "SMYD3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55D68", "map_id": "Q55D68", "name": "cnrI", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269768", "map_id": "DDB_G0269768", "name": "cnrI", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10604245", "map_id": "none", "name": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604187", "map_id": "none", "name": "Me2K10-histone H3", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10604237", "map_id": "none", "name": "Me3K10-histone H3", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10604242", "map_id": "Q54HS3", "name": "set1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10606212", "map_id": "none", "name": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10606199", "map_id": "none", "name": "MeK80-histone H3", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10606204", "map_id": "none", "name": "Me2K80-histone H3", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10606209", "map_id": "Q55AX2", "name": "dotA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0271626", "map_id": "DDB_G0271626", "name": "dotA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10604439", "map_id": "none", "name": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604436", "map_id": "none", "name": "SETD3, SETD7, WHSC1L1, Core MLL complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54J80", "map_id": "Q54J80", "name": "SETD7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288227", "map_id": "DDB_G0288227", "name": "SETD7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10606166", "map_id": "none", "name": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604185", "map_id": "none", "name": "MeK37-histone H3", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10606159", "map_id": "none", "name": "Me2K37-histone H3", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10604312", "map_id": "none", "name": "Homologues of SMYD2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54ZX8", "map_id": "Q54ZX8", "name": "SMYD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0294629", "map_id": "DDB_G0294629", "name": "SMYD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54D67", "map_id": "Q54D67", "name": "SMYD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q557F6", "map_id": "Q557F6", "name": "SMYD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DL6", "map_id": "Q54DL6", "name": "SMYD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q557F7", "map_id": "Q557F7", "name": "SMYD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GG3", "map_id": "Q54GG3", "name": "SMYD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DC8", "map_id": "Q55DC8", "name": "bopA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270830", "map_id": "DDB_G0270830", "name": "bopA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FX4", "map_id": "Q55FX4", "name": "SMYD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54R14", "map_id": "Q54R14", "name": "SMYD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B0G196", "map_id": "B0G196", "name": "SMYD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XN6", "map_id": "Q54XN6", "name": "SMYD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C7G064", "map_id": "C7G064", "name": "SMYD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10604315", "map_id": "none", "name": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10606219", "map_id": "none", "name": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10606217", "map_id": "none", "name": "Me3K80-histone H3", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10604909", "map_id": "none", "name": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604906", "map_id": "none", "name": "Core MLL complex, SMYD3, PRDM9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10606221", "map_id": "none", "name": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10589176", "map_id": "none", "name": "ABCG1-mediated transport of intracellular cholesterol to the cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10589173", "map_id": "none", "name": "ABCG1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10604343", "map_id": "none", "name": "HSF1-mediated gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604325", "map_id": "none", "name": "HSF1 trimer:target gene", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10604331", "map_id": "none", "name": "Heat shock inducible proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10604336", "map_id": "none", "name": "p-S230-HSF1 trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10604341", "map_id": "none", "name": "p-S326-HSF1 trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10604364", "map_id": "none", "name": "Phosphorylation of HSF1 at Ser326 induces transactivation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604361", "map_id": "none", "name": "mTORC1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10590646", "map_id": "none", "name": "Activation of EPACs by cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10590644", "map_id": "none", "name": "Rap1 cAMP-GEFs:cAMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10594377", "map_id": "none", "name": "PKA/PKG phosphorylate Rap1GAP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10590629", "map_id": "none", "name": "Homologues of RAP1GAP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54Q75", "map_id": "Q54Q75", "name": "SIPA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284065", "map_id": "DDB_G0284065", "name": "SIPA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SS8", "map_id": "Q54SS8", "name": "rapgapB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282247", "map_id": "DDB_G0282247", "name": "rapgapB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10594364", "map_id": "none", "name": "Homologues of p-S7-RAP1GAP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10594374", "map_id": "none", "name": "PKA catalytic subunits, PKG type I", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10590634", "map_id": "none", "name": "Rap1 signal termination by Rap1GAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10590631", "map_id": "none", "name": "Rap1 GTPase-activating proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10590655", "map_id": "none", "name": "Rap1 sequesters Raf1 to inhibit ERK cascade", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10590653", "map_id": "none", "name": "Rap1-GTP:Raf1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10582742", "map_id": "none", "name": "Excision of 8-oxoguanine by OGG1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10582737", "map_id": "none", "name": "OGG1:(8oxoG:Cyt)-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_110242", "map_id": "CHEBI:44605", "name": "8oxoG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10582763", "map_id": "none", "name": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10582758", "map_id": "none", "name": "MUTYH:(8oxoG:Ade)-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q1ZXP7", "map_id": "Q1ZXP7", "name": "MYH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270764", "map_id": "DDB_G0270764", "name": "MYH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5635947", "map_id": "CHEBI:16708", "name": "Ade", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10582760", "map_id": "none", "name": "MUTYH:AP-dsDNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10592618", "map_id": "none", "name": "Interaction of PAK1 with Rac1-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10592615", "map_id": "none", "name": "pPAK1:Rac1-GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10612893", "map_id": "none", "name": "LIPs hydrolyse TG to DAG and RCOOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_6789319", "map_id": "CHEBI:33575", "name": "RCOOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10612890", "map_id": "none", "name": "keratinocyte LIPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q55EU1", "map_id": "Q55EU1", "name": "LIPF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268966", "map_id": "DDB_G0268966", "name": "LIPF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55EU8", "map_id": "Q55EU8", "name": "LIPF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55EU9", "map_id": "Q55EU9", "name": "LIPF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10594235", "map_id": "none", "name": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10594231", "map_id": "none", "name": "AGER ligands", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:60125", "map_id": "CHEBI:60125", "name": "CHEBI:60125", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:53014", "map_id": "CHEBI:53014", "name": "CHEBI:53014", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10594227", "map_id": "Q54JR7", "name": "AGER", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0287833", "map_id": "DDB_G0287833", "name": "MCAM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10594233", "map_id": "none", "name": "AGER ligands:AGER", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54JR7", "map_id": "Q54JR7", "name": "MCAM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617470", "map_id": "none", "name": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10617458", "map_id": "none", "name": "RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54B89", "map_id": "Q54B89", "name": "SNAPC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293830", "map_id": "DDB_G0293830", "name": "SNAPC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10617467", "map_id": "none", "name": "RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10627486", "map_id": "none", "name": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10622861", "map_id": "none", "name": "KEAP1:CUL3:RBX1:NFE2L2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_9714134", "map_id": "none", "name": "NFE2L2 inducers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10627484", "map_id": "none", "name": "NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10591159", "map_id": "none", "name": "trans-Golgi Network Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10591135", "map_id": "none", "name": "Homologues of SH3GL2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10591129", "map_id": "none", "name": "Clathrin Triskelion", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10591141", "map_id": "none", "name": "Homologues of DNM2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10591123", "map_id": "none", "name": "Cargo:AP-1:Arf1-GTP:beta-Arrestin-1:Vamp Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q54HS9", "map_id": "Q54HS9", "name": "apm1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289247", "map_id": "DDB_G0289247", "name": "apm1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WW3", "map_id": "Q54WW3", "name": "ap1s1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279359", "map_id": "DDB_G0279359", "name": "ap1s1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B0G185", "map_id": "B0G185", "name": "ap1s2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0295711", "map_id": "DDB_G0295711", "name": "ap1s2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8I8U2", "map_id": "Q8I8U2", "name": "ap1g1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281957", "map_id": "DDB_G0281957", "name": "ap1g1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10589294", "map_id": "none", "name": "Arf1-GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10591157", "map_id": "none", "name": "Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10591320", "map_id": "none", "name": "trans-Golgi Network Vesicle Scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10591317", "map_id": "none", "name": "Cargo:AP-1:Beta-arrestin:Clathrin Triskelion:Vamp Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_437051", "compartment_display": "cytoplasmic vesicle membrane", "complex": "true" }, { "id": "reaction_10589780", "map_id": "none", "name": "MAOA:FAD deaminates DA to DOPAC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_159362", "map_id": "CHEBI:18243", "name": "DA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_9677997", "map_id": "CHEBI:41941", "name": "DOPAC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10589782", "map_id": "none", "name": "MAOA:FAD deaminates 3MT to HVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8954997", "map_id": "CHEBI:1582", "name": "3MT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9677992", "map_id": "CHEBI:545959", "name": "HVA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10604787", "map_id": "none", "name": "ABCB9 transports peptides from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5223341", "map_id": "none", "name": "23mer peptide", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5223344", "map_id": "none", "name": "23mer peptide", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10604784", "map_id": "none", "name": "ABCB9 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10597683", "map_id": "none", "name": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_1369066", "map_id": "CHEBI:8337", "name": "porphyrin", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1369027", "map_id": "CHEBI:8337", "name": "porphyrin", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10597680", "map_id": "none", "name": "MTABC3 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q8T9W2", "map_id": "Q8T9W2", "name": "abcB5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292554", "map_id": "DDB_G0292554", "name": "abcB5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10590190", "map_id": "none", "name": "ABC7, mABC1 and mABC2 mediate heme transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10590187", "map_id": "none", "name": "Heme transporters", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10619974", "map_id": "none", "name": "CFTR transits to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10619958", "map_id": "none", "name": "Homologues of misfolded CFTR", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10590243", "map_id": "none", "name": "Homologues of CFTR", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10618468", "map_id": "none", "name": "ABCA5 transports CHOL from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8848047", "map_id": "CHEBI:16113", "name": "CHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10618465", "map_id": "none", "name": "Homologues of ABCA5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10590231", "map_id": "none", "name": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10590229", "map_id": "none", "name": "PEX19:ABCD1/2/3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q555I0", "map_id": "Q555I0", "name": "pex19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274873", "map_id": "DDB_G0274873", "name": "pex19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10590211", "map_id": "Q54U86", "name": "pex3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "false" }, { "id": "DDB_G0281213", "map_id": "DDB_G0281213", "name": "pex3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10590203", "map_id": "none", "name": "ABCD1-3 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "species_10590227", "map_id": "Q555I0", "name": "pex19", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10589110", "map_id": "none", "name": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_265784", "map_id": "none", "name": "sterols", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:26125", "map_id": "CHEBI:26125", "name": "CHEBI:26125", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_265781", "map_id": "none", "name": "sterols", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10589107", "map_id": "none", "name": "ABCG5:ABCG8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10597819", "map_id": "none", "name": "ABCG4 may mediate cholesterol efflux", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_171149", "map_id": "CHEBI:16113", "name": "CHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10597816", "map_id": "none", "name": "ABCG4 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10597674", "map_id": "none", "name": "ABCAs mediate lipid efflux", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10597671", "map_id": "none", "name": "ABCA cholesterol transporters", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10597676", "map_id": "none", "name": "ABCAs mediate lipid influx", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10607964", "map_id": "none", "name": "ABCA12 transports lipids from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5682283", "map_id": "CHEBI:18059", "name": "lipids", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5229279", "map_id": "CHEBI:18059", "name": "lipids", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10607961", "map_id": "none", "name": "Homologues of ABCA12", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10590206", "map_id": "none", "name": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_382577", "map_id": "CHEBI:15904", "name": "LCFA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_382571", "map_id": "CHEBI:15904", "name": "LCFA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10590246", "map_id": "none", "name": "HCO3- transport through ion channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_425425", "map_id": "CHEBI:17544", "name": "HCO3-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10597798", "map_id": "none", "name": "The ABCC family mediates organic anion transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1454930", "map_id": "CHEBI:25696", "name": "organic anion", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1454919", "map_id": "CHEBI:25696", "name": "organic anion", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10597795", "map_id": "none", "name": "ABCCs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10619962", "map_id": "none", "name": "misfolded CFTR is degraded by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10619960", "map_id": "none", "name": "Ub-misfolded nascent CFTR", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10597848", "map_id": "none", "name": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_1131652", "map_id": "CHEBI:35703", "name": "a xenobiotic", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1467459", "map_id": "CHEBI:35703", "name": "a xenobiotic", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10597845", "map_id": "none", "name": "ABCA8/B1/B5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10607707", "map_id": "none", "name": "ABCB4 transports PC from plasma membrane to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_382539", "map_id": "CHEBI:16110", "name": "PC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10607704", "map_id": "none", "name": "Homologues of ABCB4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10597867", "map_id": "none", "name": "ABCA4 mediates atRAL transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74000", "compartment_display": "photoreceptor outer segment membrane" }, { "id": "species_2466098", "map_id": "CHEBI:17898", "name": "atRAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "false" }, { "id": "species_975622", "map_id": "CHEBI:17898", "name": "atRAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10597864", "map_id": "none", "name": "Homologues of ABCA4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "true" }, { "id": "reaction_10604826", "map_id": "none", "name": "ABCF1 binds EIF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10604822", "map_id": "Q8T6B4", "name": "abcF4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0267436", "map_id": "DDB_G0267436", "name": "abcF4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10604824", "map_id": "none", "name": "ABCF1:EIF2S1:EIF2S2:EIF2S3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8T6B4", "map_id": "Q8T6B4", "name": "abcF4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10607710", "map_id": "none", "name": "CFTR transports Cl- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_352022", "map_id": "CHEBI:17996", "name": "Cl-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_188972", "map_id": "CHEBI:17996", "name": "Cl-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10584149", "map_id": "none", "name": "Phosphorylation of TSC2 by PKB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10584146", "map_id": "Q54VB2", "name": "phospho-p-S939,S1130,T1462-TSC2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10624166", "map_id": "none", "name": "RASA1 stimulates RAS GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10624163", "map_id": "none", "name": "p21 RAS:GTP:RASA1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10624168", "map_id": "none", "name": "RASA1 binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10617858", "map_id": "none", "name": "SYS1 binds AcM-ARFRP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10617856", "map_id": "none", "name": "AcM-ARFRP1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54QU7", "map_id": "Q54QU7", "name": "arlD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283631", "map_id": "DDB_G0283631", "name": "arlD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10617826", "map_id": "Q55E69", "name": "sys1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "false" }, { "id": "DDB_G0269368", "map_id": "DDB_G0269368", "name": "sys1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10617836", "map_id": "none", "name": "AcM-ARFRP1:GTP:SYS1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "Q55E69", "map_id": "Q55E69", "name": "sys1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617680", "map_id": "none", "name": "RIC1:RGP1 recruits RAB6:GDP to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10617658", "map_id": "none", "name": "RAB6:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10617670", "map_id": "none", "name": "RIC1:RGP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "species_10617678", "map_id": "none", "name": "RAB6:GDP:RIC1:RGP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10618272", "map_id": "none", "name": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10618267", "map_id": "none", "name": "STX10:STX16:VTI1A:VAMP3:NSF hexamer:SNAPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "Q54GB3", "map_id": "Q54GB3", "name": "sybB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290363", "map_id": "DDB_G0290363", "name": "sybB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10618041", "map_id": "Q54GB3", "name": "sybB", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "false" }, { "id": "species_10617977", "map_id": "Q551H5", "name": "STX16", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "false" }, { "id": "species_10617975", "map_id": "Q54I20", "name": "STX10", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "false" }, { "id": "species_10617985", "map_id": "none", "name": "Homologues of VTI1A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10617687", "map_id": "none", "name": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10617684", "map_id": "none", "name": "RAB6:GTP:RIC1:RGP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10618359", "map_id": "none", "name": "RAB43:GTP binds USP8NL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10618357", "map_id": "none", "name": "Homologues of USP6NL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54Z16", "map_id": "Q54Z16", "name": "TBC1D10A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289735", "map_id": "DDB_G0289735", "name": "TBC1D10A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54H32", "map_id": "Q54H32", "name": "TBC1D10A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10618342", "map_id": "none", "name": "RAB43:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "Q54SD0", "map_id": "Q54SD0", "name": "rabS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282537", "map_id": "DDB_G0282537", "name": "rabS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10618344", "map_id": "none", "name": "RAB43:GTP:USP6NL", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10618312", "map_id": "none", "name": "cis-SNARE binds SNAPs and NSF hexamer at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10618308", "map_id": "none", "name": "STX6:STX16:VTI1A:VAMP4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "species_10618310", "map_id": "none", "name": "STX6:STX16:VTI1A:VAMP4:NSF hexamer:3xSNAPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10618351", "map_id": "none", "name": "RAB43 hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10618348", "map_id": "none", "name": "RAB43:GDP:USP6NL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10617852", "map_id": "none", "name": "ARFRP1 recruits ARL1 to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10617844", "map_id": "none", "name": "MyrG-ARL1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54JB7", "map_id": "Q54JB7", "name": "arl1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288163", "map_id": "DDB_G0288163", "name": "arl1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10617850", "map_id": "none", "name": "AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10617869", "map_id": "none", "name": "ARL1 recruits TGN Golgin homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10617865", "map_id": "none", "name": "TMF1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q556B3", "map_id": "Q556B3", "name": "TMF1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274785", "map_id": "DDB_G0274785", "name": "TMF1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10617867", "map_id": "none", "name": "AcG-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:TGN Golgin dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10618269", "map_id": "none", "name": "SNAPs and NSF hexamer bind cis-SNARE at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10618103", "map_id": "none", "name": "STX10:STX16:VTI1A:VAMP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10623407", "map_id": "none", "name": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_8949232", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_8949220", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10623404", "map_id": "none", "name": "MCU complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q54JS1", "map_id": "Q54JS1", "name": "MICU1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287825", "map_id": "DDB_G0287825", "name": "MICU1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LT0", "map_id": "Q54LT0", "name": "MCUB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286429", "map_id": "DDB_G0286429", "name": "MCUB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10592489", "map_id": "none", "name": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10592486", "map_id": "none", "name": "SLC39A1-4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q55EA1", "map_id": "Q55EA1", "name": "zntD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269326", "map_id": "DDB_G0269326", "name": "zntD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MB9", "map_id": "Q54MB9", "name": "zntC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286049", "map_id": "DDB_G0286049", "name": "zntC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10583681", "map_id": "none", "name": "Activation of Cdc25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10583669", "map_id": "Q54QM6", "name": "cdc25", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10583672", "map_id": "Q54QM6", "name": "phospho-cdc25", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10583700", "map_id": "none", "name": "Inactivation of Wee1 kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10577525", "map_id": "Q54ZN3", "name": "WEE1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0277539", "map_id": "DDB_G0277539", "name": "WEE1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10583695", "map_id": "Q54ZN3", "name": "phospho-p-S53-WEE1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10583863", "map_id": "none", "name": "Inactivation of Myt1 kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10583858", "map_id": "Q54F40", "name": "PKMYT1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0291133", "map_id": "DDB_G0291133", "name": "phospho-p-PKMYT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10583861", "map_id": "Q54F40", "name": "phospho-p-PKMYT1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10600890", "map_id": "none", "name": "Fibrillin-1 binds latent TGF-beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10600886", "map_id": "none", "name": "LTBPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q559U0", "map_id": "Q559U0", "name": "CD93", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278613", "map_id": "DDB_G0278613", "name": "CD93", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YP0", "map_id": "Q54YP0", "name": "CD93", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10600888", "map_id": "none", "name": "LTBPs:Fibrillin-1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10600223", "map_id": "none", "name": "Fibrillin microfibril assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10600193", "map_id": "none", "name": "Fibrillin peptides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10600221", "map_id": "none", "name": "Fibrillin 1,2,(3)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10601589", "map_id": "none", "name": "Phosphorylation of MEK4 by MEKK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10593048", "map_id": "Q54HS0", "name": "MAP2K4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10593058", "map_id": "Q54HS0", "name": "phospho-p-S257,T261-MAP2K4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10601580", "map_id": "none", "name": "Homologues of p-T1400,T1412-MAP3K1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10601583", "map_id": "none", "name": "Phosphorylation of MEK7 by MEKK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10593046", "map_id": "Q54HS0", "name": "MAP2K7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10593054", "map_id": "Q54HS0", "name": "phospho-p-S271,T275-MAP2K7", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10626182", "map_id": "none", "name": "CaMKK autophosphorylates in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10626175", "map_id": "none", "name": "CaMKK:CALM1:4xCa2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10626179", "map_id": "none", "name": "p-CaMKK:CALM1:4xCa2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10626191", "map_id": "none", "name": "CAMK1 binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10626187", "map_id": "P25323", "name": "mlkA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0279925", "map_id": "DDB_G0279925", "name": "mlkA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10626189", "map_id": "none", "name": "CAMK1:CALM1:4xCa2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P25323", "map_id": "P25323", "name": "mlkA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10585189", "map_id": "none", "name": "Formation of Cyclin A:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10577493", "map_id": "P34112", "name": "cdk1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10584819", "map_id": "none", "name": "CCNA", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10585187", "map_id": "none", "name": "CCNA:CDK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10585460", "map_id": "none", "name": "Translocation of Cyclin A:Cdk2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10585380", "map_id": "none", "name": "CCNA:CDK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10585924", "map_id": "none", "name": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10585920", "map_id": "none", "name": "FZR1,p-S795-RB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10585922", "map_id": "none", "name": "p-FZR1,p-RB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10585927", "map_id": "none", "name": "CAK-mediated phosphorylation of Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10580662", "map_id": "none", "name": "CAK", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10585382", "map_id": "none", "name": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10585378", "map_id": "none", "name": "CCNA:p-Y15-CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10585914", "map_id": "none", "name": "Degradation of ubiquitinated p27/p21 by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10585912", "map_id": "none", "name": "Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "B0G102", "map_id": "B0G102", "name": "cks1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271642", "map_id": "DDB_G0271642", "name": "cks1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10585908", "map_id": "none", "name": "CUL1:SKP1:SKP2:CKS1B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10585439", "map_id": "none", "name": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10577531", "map_id": "C7FZZ4", "name": "CABLES1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0302543", "map_id": "DDB_G0302543", "name": "CABLES1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10601123", "map_id": "none", "name": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10601103", "map_id": "none", "name": "Cohesin:PDS5:WAPAL:Chromosomal Arm", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10601111", "map_id": "none", "name": "Ac-Cohesin:PDS5:WAPAL:Chromosomal Arm", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10601120", "map_id": "none", "name": "ESCO", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54W25", "map_id": "Q54W25", "name": "ESCO2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279959", "map_id": "DDB_G0279959", "name": "ESCO2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10601155", "map_id": "none", "name": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10601151", "map_id": "none", "name": "Cohesin:PDS5:WAPAL:Centromere", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10601153", "map_id": "none", "name": "Ac-Cohesin:PDS5:WAPAL:Centromere", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10585939", "map_id": "none", "name": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10585916", "map_id": "none", "name": "CCNA:p-T160-CDK2:E2F1/E2F3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10585936", "map_id": "none", "name": "CCNA:p-T160-CDK2:p-E2F1/p-E2F3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10585918", "map_id": "none", "name": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10619259", "map_id": "none", "name": "SCF-FBXL7 ubiquitinates AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10619191", "map_id": "none", "name": "SCF-FBXL7:AURKA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10619256", "map_id": "none", "name": "SCF-FBXL7:PolyUb-AURKA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10619193", "map_id": "none", "name": "SCF:FBXL7 binds AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10585350", "map_id": "Q54WX4", "name": "aurK", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10619189", "map_id": "none", "name": "SKP1:CUL1:RBX1:FBXL7", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10619261", "map_id": "none", "name": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10584837", "map_id": "none", "name": "Translocation of Cdc25 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10584833", "map_id": "none", "name": "CDC25", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10584835", "map_id": "none", "name": "CDC25", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10619653", "map_id": "none", "name": "PP2A demethylation by PPME1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10619637", "map_id": "none", "name": "MeL-PP2A", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10597550", "map_id": "none", "name": "PP2A", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_8857797", "map_id": "CHEBI:17790", "name": "methanol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10619650", "map_id": "Q54TN3", "name": "ppme1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0281651", "map_id": "DDB_G0281651", "name": "ppme1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10584825", "map_id": "none", "name": "Translocation of Cdc25B to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10584821", "map_id": "Q54QM6", "name": "cdc25", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10584823", "map_id": "Q54QM6", "name": "cdc25", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10584829", "map_id": "none", "name": "Translocation of active Cdc25C to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10584827", "map_id": "Q54QM6", "name": "phospho-cdc25", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10619645", "map_id": "none", "name": "PP2A methylation by LCMT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10619642", "map_id": "Q54J74", "name": "LCMT1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0288271", "map_id": "DDB_G0288271", "name": "LCMT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10601941", "map_id": "none", "name": "Cytosolic PLK1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10601061", "map_id": "none", "name": "Autocleavage of ESPL1 (Separase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10601050", "map_id": "Q54G81", "name": "ESPL1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0290325", "map_id": "DDB_G0290325", "name": "ESPL1(1-1506)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10601058", "map_id": "none", "name": "ESPL1 Autocleaved", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54G81", "map_id": "Q54G81", "name": "ESPL1(1-1506)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10600560", "map_id": "none", "name": "MASTL (GWL) phosphorylates ARPP19", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10600546", "map_id": "Q54QV9", "name": "ARPP19", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0283571", "map_id": "DDB_G0283571", "name": "phospho-p-S62-ARPP19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10600549", "map_id": "Q54QV9", "name": "phospho-p-S62-ARPP19", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10600557", "map_id": "Q559T8", "name": "phospho-p-T194,T207,T741-MASTL", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0272282", "map_id": "DDB_G0272282", "name": "phospho-p-T194,T207,T741-MASTL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10600987", "map_id": "none", "name": "MASTL phosphorylates ENSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10600982", "map_id": "Q54QV9", "name": "ENSA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10600985", "map_id": "Q54QV9", "name": "phospho-p-S67-ENSA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10600815", "map_id": "none", "name": "PLK1 phosphorylates GORASP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10600807", "map_id": "none", "name": "p-T216,S274,S373-GORASP1:p-S37-GOLGA2:p-RAB1:GTP:p-T210-PLK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10600812", "map_id": "none", "name": "p-T216,S189,S274,S373-GORASP1:p-S37-GOLGA2:p-RAB1:GTP:p-T210-PLK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10585968", "map_id": "none", "name": "Cyclin E:CDK2-mediated phosphorylation of RB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10585963", "map_id": "none", "name": "CCNE:p-T160-CDK2:hypophosphorylated RB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10577271", "map_id": "none", "name": "Cyclin E:p-T160-CDK2", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10583328", "map_id": "Q54FX2", "name": "phospho-rblA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10577511", "map_id": "none", "name": "Formation of Cyclin E:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10577507", "map_id": "none", "name": "CCNE", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10577509", "map_id": "none", "name": "CCNE:CDK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10585959", "map_id": "none", "name": "CAK-mediated phosphorylation of Cyclin E:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10577515", "map_id": "none", "name": "CCNE:CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10577542", "map_id": "none", "name": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10577520", "map_id": "none", "name": "Cyclin E:p-CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10577533", "map_id": "none", "name": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10585965", "map_id": "none", "name": "Association of Rb with Cyclin E:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10577550", "map_id": "Q54FX2", "name": "phospho-rblA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10583775", "map_id": "none", "name": "Translocation of Cyclin E:Cdk2 complex to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "reaction_10583356", "map_id": "none", "name": "PP2A mediated localization of RB1 protein in chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_113656", "map_id": "none", "name": "RNA primer-DNA primer:origin duplex with DNA damage", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10583330", "map_id": "none", "name": "RB1:RNA primer-DNA primer:origin duplex with DNA damage", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10583353", "map_id": "none", "name": "PP2A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54W95", "map_id": "Q54W95", "name": "PPP2R3B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279813", "map_id": "DDB_G0279813", "name": "PPP2R3B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10583358", "map_id": "none", "name": "Detection of damage during initiation of DNA synthesis in S-phase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10627090", "map_id": "none", "name": "RB1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10627088", "map_id": "Q54FX2", "name": "rblA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10625026", "map_id": "none", "name": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10602086", "map_id": "none", "name": "E2F1,E2F2,E2F3:TFDP1,TFDP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10625024", "map_id": "none", "name": "RB1:E2F1,E2F2,E2F3:TFDP1,TFDP2:", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10597553", "map_id": "none", "name": "Dephosphorylation of p107 (RBL1) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10597263", "map_id": "Q54FX2", "name": "phospho-rblA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10597584", "map_id": "none", "name": "Ubiquitination of p130 (RBL2) by SCF (Skp2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10597577", "map_id": "none", "name": "p-T401,S672,1035-RBL2:SCF(Skp2):Cks1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10597581", "map_id": "none", "name": "Ub-p-T401,S672,1035-RBL2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10597555", "map_id": "none", "name": "Dephosphorylation of p130 (RBL2) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10597251", "map_id": "Q54FX2", "name": "phospho-rblA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10597579", "map_id": "none", "name": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10600926", "map_id": "none", "name": "HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10600922", "map_id": "none", "name": "Transthyretin tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q54LD6", "map_id": "Q54LD6", "name": "TTR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286691", "map_id": "DDB_G0286691", "name": "TTR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10600924", "map_id": "none", "name": "HSPG2:FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10603454", "map_id": "none", "name": "Laminins bind HSPG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10603450", "map_id": "none", "name": "Laminins with alpha-1, -2 or -5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10603452", "map_id": "none", "name": "Laminins with alpha-1, -2 or -5:HSPG2(22-4391)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10626256", "map_id": "none", "name": "SPHK1 phosphorylates sphingosine in response to E2 stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10582777", "map_id": "none", "name": "Formation of Pol zeta complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10582773", "map_id": "Q54S00", "name": "mad2l2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0282747", "map_id": "DDB_G0282747", "name": "mad2l2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10582768", "map_id": "Q55AZ3", "name": "REV3L", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0271608", "map_id": "DDB_G0271608", "name": "REV3L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10582775", "map_id": "none", "name": "POLZ", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55AZ3", "map_id": "Q55AZ3", "name": "REV3L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54S00", "map_id": "Q54S00", "name": "mad2l2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10594097", "map_id": "none", "name": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_727746", "map_id": "none", "name": "nucleosides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_727782", "map_id": "none", "name": "nucleosides", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_10594084", "map_id": "none", "name": "Homologues of SLC29A3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "Q54TT2", "map_id": "Q54TT2", "name": "SLC29A4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283439", "map_id": "DDB_G0283439", "name": "SLC29A4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TT3", "map_id": "Q54TT3", "name": "SLC29A4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54R17", "map_id": "Q54R17", "name": "SLC29A4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10594099", "map_id": "none", "name": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_727737", "map_id": "none", "name": "ligands of SLC29A4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:28918", "map_id": "CHEBI:28918", "name": "CHEBI:28918", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_209789", "map_id": "CHEBI:18357", "name": "NAd", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_727774", "map_id": "none", "name": "ligands of SLC29A4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10594073", "map_id": "none", "name": "Homologues of SLC29A4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10582532", "map_id": "none", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_179743", "map_id": "none", "name": "ligands of SLC28A3 & 29A1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_179737", "map_id": "none", "name": "ligands of SLC28A3 & 29A1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10582529", "map_id": "none", "name": "SLC29A1-like proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10582534", "map_id": "none", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10584043", "map_id": "none", "name": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10584040", "map_id": "none", "name": "SLC25A5 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "O97470", "map_id": "O97470", "name": "ancA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267454", "map_id": "DDB_G0267454", "name": "ancA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10582525", "map_id": "none", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_179747", "map_id": "none", "name": "ligands of SLC29A2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:16040", "map_id": "CHEBI:16040", "name": "CHEBI:16040", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_179742", "map_id": "none", "name": "ligands of SLC29A2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10582522", "map_id": "none", "name": "SLC29A2-like proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10594076", "map_id": "none", "name": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10582527", "map_id": "none", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10594129", "map_id": "none", "name": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10594126", "map_id": "Q869W7", "name": "slc35b4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "DDB_G0275061", "map_id": "DDB_G0275061", "name": "slc35b4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10594132", "map_id": "none", "name": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_742353", "map_id": "CHEBI:16082", "name": "UDP-Xyl", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10594095", "map_id": "none", "name": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_727753", "map_id": "CHEBI:15351", "name": "Ac-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10594092", "map_id": "Q1ZXJ4", "name": "SLC33A1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "DDB_G0278059", "map_id": "DDB_G0278059", "name": "SLC33A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10620690", "map_id": "none", "name": "SLC36A4 transports extracellular L-Pro to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_352033", "map_id": "CHEBI:60039", "name": "L-Pro", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10589664", "map_id": "none", "name": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_375765", "map_id": "none", "name": "L-Arg, L-Lys, L-Orn", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_375781", "map_id": "none", "name": "L-Arg, L-Lys, L-Orn", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10589661", "map_id": "none", "name": "Homologues of SLC7A2-1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54KK4", "map_id": "Q54KK4", "name": "SLC7A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0346922", "map_id": "DDB_G0346922", "name": "SLC7A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54F04", "map_id": "Q54F04", "name": "SLC7A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KK2", "map_id": "Q54KK2", "name": "SLC7A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KK5", "map_id": "Q54KK5", "name": "SLC7A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54W03", "map_id": "Q54W03", "name": "SLC7A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54EJ9", "map_id": "Q54EJ9", "name": "ctrA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291227", "map_id": "DDB_G0291227", "name": "ctrA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KK3", "map_id": "Q54KK3", "name": "SLC7A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10589683", "map_id": "none", "name": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10589680", "map_id": "none", "name": "Homologues of SLC7A3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10589702", "map_id": "none", "name": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10589699", "map_id": "none", "name": "Homologues of SLC7A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10589704", "map_id": "none", "name": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10624530", "map_id": "none", "name": "CHEK1 phosphorylates E2F6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10623848", "map_id": "Q54Q23", "name": "E2F6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10624528", "map_id": "Q54Q23", "name": "phospho-p-S12-E2F6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10623920", "map_id": "none", "name": "E2F6 binds TFDP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10597242", "map_id": "Q7KWP1", "name": "TFDP2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10623918", "map_id": "none", "name": "E2F6:TFDP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10623931", "map_id": "none", "name": "E2F6:TFDP1 binds EPC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10623850", "map_id": "none", "name": "E2F6:TFDP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10623927", "map_id": "Q54JZ0", "name": "EPC1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0287727", "map_id": "DDB_G0287727", "name": "EPC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10623929", "map_id": "none", "name": "E2F6:TFDP1:EPC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54JZ0", "map_id": "Q54JZ0", "name": "EPC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10623852", "map_id": "none", "name": "E2F6 binds TFDP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10597240", "map_id": "Q7KWP1", "name": "TFDP1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10595753", "map_id": "none", "name": "KRAB-ZNF / KAP Interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10595749", "map_id": "none", "name": "KRAB-ZNF", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54UG9", "map_id": "Q54UG9", "name": "TFIIIA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281085", "map_id": "DDB_G0281085", "name": "TFIIIA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10595441", "map_id": "Q54MF7", "name": "TRIM28", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10595751", "map_id": "none", "name": "KRAB-ZNF / KAP Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10612161", "map_id": "none", "name": "PARP1 or PARP2 PARylates DDB2 and autoPARylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10612159", "map_id": "none", "name": "Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54LV1", "map_id": "Q54LV1", "name": "rcbA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286357", "map_id": "DDB_G0286357", "name": "rcbA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WU9", "map_id": "Q54WU9", "name": "RAD23B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279421", "map_id": "DDB_G0279421", "name": "RAD23B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q869L7", "map_id": "Q869L7", "name": "RAD23B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10611122", "map_id": "none", "name": "Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10612163", "map_id": "none", "name": "PARP1 or PARP2 binds DDB2 at GG-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10612157", "map_id": "none", "name": "Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10611143", "map_id": "none", "name": "XPC binds RAD23 and CETN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10603915", "map_id": "none", "name": "Homologues of CETN2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10611111", "map_id": "none", "name": "RAD23", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10611141", "map_id": "none", "name": "XPC:RAD23:CETN2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10612471", "map_id": "none", "name": "UV-DDB ubiquitinates XPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10611197", "map_id": "none", "name": "XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10611199", "map_id": "none", "name": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10611195", "map_id": "none", "name": "UV-DDB:COP9 Signalosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10611139", "map_id": "none", "name": "TFIIH binds GG-NER site to form a verification complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10611137", "map_id": "none", "name": "Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10582642", "map_id": "none", "name": "Formation of ERCC1:XPF heterodimeric complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10582638", "map_id": "Q54PN5", "name": "ercc4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0284419", "map_id": "DDB_G0284419", "name": "ercc4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10582633", "map_id": "Q55GG6", "name": "ercc1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0267682", "map_id": "DDB_G0267682", "name": "ercc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10582640", "map_id": "none", "name": "ERCC1:ERCC4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q55GG6", "map_id": "Q55GG6", "name": "ercc1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PN5", "map_id": "Q54PN5", "name": "ercc4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10612919", "map_id": "none", "name": "SUMOylation of XPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10611132", "map_id": "none", "name": "Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10612903", "map_id": "none", "name": "SUMO1,2,3:UBE2I", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10612914", "map_id": "none", "name": "Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10612916", "map_id": "none", "name": "PIAS1,3", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10611135", "map_id": "none", "name": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10611128", "map_id": "none", "name": "Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10611950", "map_id": "none", "name": "USP45 deubiquitinates ERCC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10611945", "map_id": "none", "name": "Ub:ERCC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10611947", "map_id": "Q86KB3", "name": "USP45", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10612448", "map_id": "none", "name": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10612443", "map_id": "none", "name": "TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54KS3", "map_id": "Q54KS3", "name": "POLK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287149", "map_id": "DDB_G0287149", "name": "POLK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10612445", "map_id": "none", "name": "TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10612419", "map_id": "none", "name": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10612415", "map_id": "none", "name": "TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10612417", "map_id": "none", "name": "TC-NER incision complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10627351", "map_id": "none", "name": "ERCC3-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10612392", "map_id": "none", "name": "TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10612403", "map_id": "none", "name": "TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10612424", "map_id": "none", "name": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10612421", "map_id": "none", "name": "TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA ", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10612456", "map_id": "none", "name": "DNA polymerases delta, epsilon or kappa bind the TC-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10612452", "map_id": "none", "name": "PCNA homotrimer,MonoUb:K164-PCNA homotrimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10612450", "map_id": "none", "name": "POLD,POLE,POLK", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10612454", "map_id": "none", "name": "TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10612395", "map_id": "none", "name": "ERCC2-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10581574", "map_id": "none", "name": "Formation of RAD50:MRE11 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10581565", "map_id": "Q54CS9", "name": "rad50", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10581570", "map_id": "Q54BN2", "name": "MRE11A", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10581572", "map_id": "none", "name": "RAD50:MRE11A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10611351", "map_id": "none", "name": "ATM phosphorylates MDC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10611348", "map_id": "none", "name": "DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:MDC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54Z32", "map_id": "Q54Z32", "name": "HIST3H3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278587", "map_id": "DDB_G0278587", "name": "HIST3H3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HV7", "map_id": "Q54HV7", "name": "H2Av3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289197", "map_id": "DDB_G0289197", "name": "H2Av3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10608053", "map_id": "none", "name": "DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10611386", "map_id": "none", "name": "MDC1 associates with gamma-H2AFX at nuclear foci", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10608042", "map_id": "none", "name": "DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10611346", "map_id": "none", "name": "MDC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10611356", "map_id": "none", "name": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10611353", "map_id": "none", "name": "DNA DSBs:p-MRN:p-S-1981,Ac-K3016-ATM:KAT5:p-Y142-H2AFX-Nucleosome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10608103", "map_id": "none", "name": "DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10627073", "map_id": "none", "name": "OGG1beta translocates to mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10627069", "map_id": "Q54CZ3", "name": "OGG1beta", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10627071", "map_id": "Q54CZ3", "name": "OGG1beta", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10580816", "map_id": "none", "name": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10580809", "map_id": "none", "name": "LIG3:XRCC1:POLB:SSB-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10580813", "map_id": "none", "name": "LIG3:XRCC1:POLB:dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10582803", "map_id": "none", "name": "Recruitment of POLB to the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10582796", "map_id": "none", "name": "APEX1:SSB(AP->5'-dRP)-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P51173", "map_id": "P51173", "name": "apeA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277701", "map_id": "DDB_G0277701", "name": "apeA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10580793", "map_id": "Q1ZXF2", "name": "polB", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10582801", "map_id": "none", "name": "POLB:APEX1:SSB(AP->5'-dRP)-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10582806", "map_id": "none", "name": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10582782", "map_id": "P51173", "name": "apeA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10580820", "map_id": "none", "name": "POLB:SSB-gap-dsDNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_30977", "map_id": "CHEBI:33447", "name": "SUGP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10580825", "map_id": "none", "name": "Resynthesis of excised residue by POLB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10580822", "map_id": "none", "name": "LIG3:XRCC1:POLB:SSB-gap-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10582808", "map_id": "none", "name": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10582786", "map_id": "none", "name": "Displacement of UNG glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10582682", "map_id": "P53766", "name": "uglA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10582784", "map_id": "none", "name": "APEX1:AP-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10582788", "map_id": "none", "name": "Displacement of NTHL1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10582675", "map_id": "Q86K43", "name": "NTH1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10582790", "map_id": "none", "name": "Displacement of OGG1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10582733", "map_id": "Q54CZ3", "name": "OGG1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10582792", "map_id": "none", "name": "Displacement of MUTYH glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10582754", "map_id": "Q1ZXP7", "name": "MYH", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10606194", "map_id": "none", "name": "LIG3 ligates NEIL1,NEIL2-generated single strand break", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10606186", "map_id": "none", "name": "NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54U78", "map_id": "Q54U78", "name": "PNKP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281229", "map_id": "DDB_G0281229", "name": "PNKP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10606191", "map_id": "none", "name": "NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10606184", "map_id": "none", "name": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10606179", "map_id": "none", "name": "NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10606181", "map_id": "none", "name": "NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10606189", "map_id": "none", "name": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10606225", "map_id": "none", "name": "Recruitment of POLB to oxidatively damaged AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10582815", "map_id": "none", "name": "APEX1:SSB(5'-ddRP)-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10582817", "map_id": "none", "name": "POLB:APEX1:SSB(5'ddRP)-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10606227", "map_id": "none", "name": "Oxidative damage to the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10606288", "map_id": "none", "name": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10606281", "map_id": "none", "name": "PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10606286", "map_id": "none", "name": "FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10606304", "map_id": "none", "name": "PARG dePARylates PARP1,PARP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_5651834", "map_id": "CHEBI:16960", "name": "ADP-D-ribose", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10606240", "map_id": "Q54Z28", "name": "PARG", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0277943", "map_id": "DDB_G0277943", "name": "PARG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10606242", "map_id": "none", "name": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10582821", "map_id": "none", "name": "POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10606235", "map_id": "none", "name": "PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10606296", "map_id": "none", "name": "LIG1 binds POLB at long-patch BER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10606292", "map_id": "none", "name": "POLB:SSB(3'poly-dNMP)-dsDNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10606294", "map_id": "none", "name": "LIG1:POLB:SSB(3'poly-dNMP)-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q869E1", "map_id": "Q869E1", "name": "lig1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10606250", "map_id": "none", "name": "POLB-mediated DNA strand displacement synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10606247", "map_id": "none", "name": "PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10606301", "map_id": "none", "name": "LIG1 bound to POLB ligates SSB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10606298", "map_id": "none", "name": "LIG1:POLB:dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10606284", "map_id": "none", "name": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10582824", "map_id": "none", "name": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10582799", "map_id": "none", "name": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10626280", "map_id": "none", "name": "ACHEIs bind ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9634838", "map_id": "none", "name": "ACHEIs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10588771", "map_id": "none", "name": "L-Glutamate loading of synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10588768", "map_id": "none", "name": "Empty Glutamate Synaptic Vesicle", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54W37", "map_id": "Q54W37", "name": "SLC17A3(1-498)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54UX4", "map_id": "Q54UX4", "name": "SLC17A3(1-498)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6TMJ9", "map_id": "Q6TMJ9", "name": "sybA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280061", "map_id": "DDB_G0280061", "name": "sybA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10588746", "map_id": "none", "name": "Glutamate loaded synaptic vesicle", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10594460", "map_id": "none", "name": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10594457", "map_id": "none", "name": "PXLP-K357-ABAT dimer:2Fe-2S", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q55FI1", "map_id": "Q55FI1", "name": "gabT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268104", "map_id": "DDB_G0268104", "name": "gabT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10589611", "map_id": "none", "name": "Metabolism of Noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5279533", "map_id": "CHEBI:27852", "name": "3,4-dihydroxyphenylglycolaldehyde", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_459", "compartment_display": "cytoplasm", "complex": "false" }, { "id": "reaction_10625621", "map_id": "none", "name": "p-S363,S380,T573 RS6K translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10625593", "map_id": "none", "name": "p-S221,T359.S363,S380,T573,T732-RSK", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10625619", "map_id": "none", "name": "p-S221,T359,S363,S380,T573,T732-RSK", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10613600", "map_id": "none", "name": "LRPP4(LRPP1-3,5) hydrolyse LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_417891", "map_id": "CHEBI:52288", "name": "LPA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10613597", "map_id": "none", "name": "Homologues of LPPR4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10590801", "map_id": "none", "name": "cAMP degradation by Phosphodiesterases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10590798", "map_id": "none", "name": "cAMP PDEs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10627473", "map_id": "none", "name": "PDE4A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10583084", "map_id": "none", "name": "Homologues of PDE4A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10626265", "map_id": "none", "name": "PDE3A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10626262", "map_id": "none", "name": "Homologues of PDE3A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10627406", "map_id": "none", "name": "PDE3B hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10627403", "map_id": "none", "name": "Homologues of PDE3B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10590562", "map_id": "none", "name": "G alpha (z) inhibits adenylate cyclase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10590558", "map_id": "none", "name": "G-protein alpha (z):GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10590560", "map_id": "none", "name": "G-protein alpha (z):GTP:Adenylate cyclase", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10624233", "map_id": "none", "name": "Active G alpha (z) binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10624229", "map_id": "none", "name": "RGS16,17,20", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10624231", "map_id": "none", "name": "G alpha (z):GTP:RGS16,17,20", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10624313", "map_id": "none", "name": "G alpha (z) in G alpha (z):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10624301", "map_id": "none", "name": "G alpha (z):GDP:RGS16,17,20", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10624303", "map_id": "none", "name": "G alpha (z):RGS complex dissociates to give inactive G alpha (z)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10594134", "map_id": "none", "name": "G-protein alpha (z):GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10590810", "map_id": "none", "name": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10590657", "map_id": "none", "name": "G-protein alpha (12/13):GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10590807", "map_id": "none", "name": "G-protein alpha (12/13):GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10625832", "map_id": "none", "name": "PIP3 recruits PDK1 and AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10625830", "map_id": "none", "name": "PDK1:AKT:PIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10590605", "map_id": "none", "name": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10590602", "map_id": "none", "name": "G-protein beta-gamma:PI3K gamma", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10602042", "map_id": "none", "name": "DHX36 binds DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602038", "map_id": "Q869Z1", "name": "DHX36", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0275313", "map_id": "DDB_G0275313", "name": "DHX36", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_3134861", "map_id": "none", "name": "Unmethylated CpG DNA", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10602040", "map_id": "none", "name": "DHX36:CpG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q869Z1", "map_id": "Q869Z1", "name": "DHX36", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10602073", "map_id": "none", "name": "MRE11 binds cytosolic DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_874088", "map_id": "CHEBI:16991", "name": "Double-stranded DNA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10602069", "map_id": "Q54BN2", "name": "MRE11A", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10602071", "map_id": "none", "name": "MRE11:dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10624938", "map_id": "none", "name": "DDX41 binds bacterial c-di-AMP, c-di-GMP ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8982080", "map_id": "none", "name": "c-di-AMP, c-di-GMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:49537", "map_id": "CHEBI:49537", "name": "CHEBI:49537", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:47037", "map_id": "CHEBI:47037", "name": "CHEBI:47037", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10602033", "map_id": "Q54KG1", "name": "ddx41", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0287361", "map_id": "DDB_G0287361", "name": "ddx41", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10624936", "map_id": "none", "name": "DDX41:c-di-AMP, c-di-GMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54KG1", "map_id": "Q54KG1", "name": "ddx41", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10605089", "map_id": "none", "name": "CLAT:AP1:CLVS bind PI(3,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_5334668", "map_id": "CHEBI:16851", "name": "PI(3,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "species_10605085", "map_id": "none", "name": "CLAT:AP1:CLVS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "species_10605087", "map_id": "none", "name": "CLAT:AP1:CLVS:PI(3,5)P2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20592", "compartment_display": "clathrin-coated endocytic vesicle", "complex": "true" }, { "id": "reaction_10604872", "map_id": "none", "name": "AP4 transports APP from trans-Golgi network to endosome lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171907", "compartment_display": "endosome lumen" }, { "id": "species_10604855", "map_id": "none", "name": "AP4:APP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "Q54VE0", "map_id": "Q54VE0", "name": "ap4e1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280427", "map_id": "DDB_G0280427", "name": "ap4e1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GPF0", "map_id": "Q9GPF0", "name": "apm4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276945", "map_id": "DDB_G0276945", "name": "apm4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NZ4", "map_id": "Q54NZ4", "name": "ap4s1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284905", "map_id": "DDB_G0284905", "name": "ap4s1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54R84", "map_id": "Q54R84", "name": "ap4b1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283319", "map_id": "DDB_G0283319", "name": "ap4b1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10604869", "map_id": "none", "name": "AP4:APP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171907", "compartment_display": "endosome lumen", "complex": "true" }, { "id": "reaction_10592299", "map_id": "none", "name": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10592293", "map_id": "none", "name": "Lysosome Destined Cargo:AP-1:Arf1-GTP:beta-Arrestin-1:Vamp Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10592297", "map_id": "none", "name": "Lysosome Destined Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10592302", "map_id": "none", "name": "trans-Golgi Network Lysosomal Vesicle Scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10592225", "map_id": "none", "name": "Lysosome Cargo:AP-1:Beta-arrestin:Clathrin Triskelion:Vamp Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10589739", "map_id": "none", "name": "Vamp7 associated Lysosome to Plasma membrane transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10589710", "map_id": "none", "name": "Homologues of SNAP23", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10589728", "map_id": "none", "name": "Homologues of VAMP7", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "Q54NW7", "map_id": "Q54NW7", "name": "vamp7A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284951", "map_id": "DDB_G0284951", "name": "vamp7A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86AQ7", "map_id": "Q86AQ7", "name": "vamp7B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277173", "map_id": "DDB_G0277173", "name": "vamp7B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10589734", "map_id": "none", "name": "Homologues of VAMP7", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10589736", "map_id": "none", "name": "Vamp7:SNAP23:Syn4 Plasma membrane vesicle docking and fusion complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10589773", "map_id": "none", "name": "Vamp2 associated secretory vesicle to plasma membrane transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10589762", "map_id": "none", "name": "Homologues of VAMP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_216813", "compartment_display": "secretory granule membrane", "complex": "true" }, { "id": "species_10589768", "map_id": "none", "name": "Homologues of VAMP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10589770", "map_id": "none", "name": "Vamp2:SNAP23:Syn4 Secretory granule docking and fusion complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10589340", "map_id": "none", "name": "trans-Golgi Network Coat Activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10589320", "map_id": "none", "name": "Arf1-GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10589337", "map_id": "none", "name": "Homologues of GBF1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10589756", "map_id": "none", "name": "Vamp8 associated secretory vesicle to plasma membrane transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10589745", "map_id": "none", "name": "Homologues of VAMP8", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_216813", "compartment_display": "secretory granule membrane", "complex": "true" }, { "id": "species_10589751", "map_id": "none", "name": "Homologues of VAMP8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10589753", "map_id": "none", "name": "Vamp8:SNAP23:Syn4 Secretory granule docking and fusion complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10586000", "map_id": "none", "name": "maltose + H2O => 2 D-glucose (maltase-glucoamylase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_188986", "map_id": "CHEBI:17306", "name": "Mal", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10585997", "map_id": "none", "name": "MGAM dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10586372", "map_id": "none", "name": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_191103", "map_id": "CHEBI:27931", "name": "maltotriose", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10585987", "map_id": "none", "name": "sucrase-isomaltase dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10585990", "map_id": "none", "name": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_189108", "map_id": "CHEBI:28912", "name": "limit dextrins", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10586374", "map_id": "none", "name": "maltose + H2O => 2 D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10585993", "map_id": "none", "name": "sucrose + H2O => glucose + fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_188980", "map_id": "CHEBI:17992", "name": "Suc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_189049", "map_id": "CHEBI:15824", "name": "Fru", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10586376", "map_id": "none", "name": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10606570", "map_id": "none", "name": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_5659875", "map_id": "CHEBI:28189", "name": "iMal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10623860", "map_id": "none", "name": "PIR oxygenates quercetin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_8953397", "map_id": "CHEBI:16243", "name": "quercetin", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_8953399", "map_id": "CHEBI:17245", "name": "CO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_8953383", "map_id": "CHEBI:16068", "name": "2PCPGCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10623857", "map_id": "Q557H8", "name": "PIR", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0273413", "map_id": "DDB_G0273413", "name": "PIR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10600033", "map_id": "none", "name": "Hydrolysis of PC to PA by PLD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10600030", "map_id": "none", "name": "PLD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10600008", "map_id": "none", "name": "Conversion of PA into DAG by PAP-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10600005", "map_id": "none", "name": "Phosphatidate phosphatase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10620323", "map_id": "none", "name": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10620318", "map_id": "none", "name": "PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q86HW6", "map_id": "Q86HW6", "name": "AAK1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280111", "map_id": "DDB_G0280111", "name": "AAK1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VV7", "map_id": "Q54VV7", "name": "AAK1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54U74", "map_id": "Q54U74", "name": "NECAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281235", "map_id": "DDB_G0281235", "name": "NECAP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KI4", "map_id": "Q54KI4", "name": "eps15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287325", "map_id": "DDB_G0287325", "name": "eps15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q555L8", "map_id": "Q555L8", "name": "PACSIN2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274805", "map_id": "DDB_G0274805", "name": "PACSIN2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GD0", "map_id": "Q54GD0", "name": "mgp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290233", "map_id": "DDB_G0290233", "name": "mgp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q75JD4", "map_id": "Q75JD4", "name": "PACSIN2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AN3", "map_id": "Q55AN3", "name": "PACSIN2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C7FZZ0", "map_id": "C7FZZ0", "name": "PACSIN2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Y50", "map_id": "Q54Y50", "name": "SNAP91", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278685", "map_id": "DDB_G0278685", "name": "SNAP91", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54UC8", "map_id": "Q54UC8", "name": "SLC2A8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281155", "map_id": "DDB_G0281155", "name": "SLC2A8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54D31", "map_id": "Q54D31", "name": "M6PR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292610", "map_id": "DDB_G0292610", "name": "M6PR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GM0", "map_id": "Q55GM0", "name": "M6PR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LD2", "map_id": "Q54LD2", "name": "M6PR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54P67", "map_id": "Q54P67", "name": "M6PR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QZ0", "map_id": "Q54QZ0", "name": "M6PR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VJ6", "map_id": "Q54VJ6", "name": "M6PR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WQ8", "map_id": "Q54WQ8", "name": "M6PR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXI3", "map_id": "Q1ZXI3", "name": "M6PR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XB6", "map_id": "Q54XB6", "name": "M6PR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CZ8", "map_id": "Q54CZ8", "name": "M6PR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GL9", "map_id": "Q55GL9", "name": "M6PR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IA6", "map_id": "Q54IA6", "name": "AMPH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288895", "map_id": "DDB_G0288895", "name": "AMPH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NT2", "map_id": "Q54NT2", "name": "BIN1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284997", "map_id": "DDB_G0284997", "name": "BIN1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B0G198", "map_id": "B0G198", "name": "DBN1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0295683", "map_id": "DDB_G0295683", "name": "DBN1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXE9", "map_id": "Q1ZXE9", "name": "hipA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285703", "map_id": "DDB_G0285703", "name": "hipA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10620320", "map_id": "none", "name": "PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10619620", "map_id": "none", "name": "Recruitment of AP-2 complex and clathrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10619610", "map_id": "none", "name": "PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10619527", "map_id": "none", "name": "AP-2 Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10619616", "map_id": "none", "name": "NECAPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10619539", "map_id": "none", "name": "Homologues of AAK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10619618", "map_id": "none", "name": "PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10620325", "map_id": "none", "name": "Endophilins recruit synaptojanins to the clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10620314", "map_id": "none", "name": "PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10620267", "map_id": "none", "name": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10598590", "map_id": "none", "name": "Homologues of PIP5K1C", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10619662", "map_id": "none", "name": "FCHo proteins bind nascent clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10619596", "map_id": "none", "name": "PI(4,5)P2:AP-2:clathrin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10619608", "map_id": "none", "name": "Homologues of SGIP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10588585", "map_id": "Q54KI4", "name": "eps15", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10619588", "map_id": "Q54KI4", "name": "eps15", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10619590", "map_id": "Q54KI4", "name": "eps15", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10619586", "map_id": "none", "name": "FCHO1,2 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10619630", "map_id": "none", "name": "AAK1 phosphorylates AP-2 mu subunit at T156", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10619627", "map_id": "none", "name": "PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10621967", "map_id": "none", "name": "RAB5 and GAPVD1 bind AP-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane" }, { "id": "species_10621961", "map_id": "none", "name": "GGC-RAB5:GDP:GAPVD1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "species_10620427", "map_id": "none", "name": "PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "Q8T867", "map_id": "Q8T867", "name": "GAK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276447", "map_id": "DDB_G0276447", "name": "GAK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10621963", "map_id": "none", "name": "PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10619890", "map_id": "none", "name": "UBQLNs bind UIM-containing adaptor proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10619886", "map_id": "none", "name": "EPS15,EPN1,EPN2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54EH1", "map_id": "Q54EH1", "name": "epnA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291512", "map_id": "DDB_G0291512", "name": "epnA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10619878", "map_id": "Q9NIF3", "name": "ubqln", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0267452", "map_id": "DDB_G0267452", "name": "ubqln", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10619888", "map_id": "none", "name": "UNQLNs:UIM proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9NIF3", "map_id": "Q9NIF3", "name": "ubqln", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10619715", "map_id": "none", "name": "COP9 and TOR1 deneddylate STON2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10619706", "map_id": "none", "name": "NEDD8-STONs:TOR1 hexamer:COP9", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10619710", "map_id": "P54672", "name": "apm2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10611062", "map_id": "Q54XV3", "name": "nedd8", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10619684", "map_id": "none", "name": "TOR1 hexamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10627348", "map_id": "none", "name": "AP2 binds chlorpromazine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9648300", "map_id": "none", "name": "chlorpromazine", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10619943", "map_id": "none", "name": "AP2:chlorpromazine", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10619717", "map_id": "none", "name": "STON2 is neddylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10619672", "map_id": "P54672", "name": "apm2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10619945", "map_id": "none", "name": "AP-2 directly binds some endocytic cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10619939", "map_id": "none", "name": "AP-2 cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10619941", "map_id": "none", "name": "AP-2:cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10620089", "map_id": "none", "name": "PICALM binds R-SNAREs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10620079", "map_id": "none", "name": "VAMP2,3,8", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10620085", "map_id": "none", "name": "PICALMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10620087", "map_id": "none", "name": "PICALM:VAMP2,3,8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10619708", "map_id": "none", "name": "NEDD8-STON binds TOR1 hexamer and COP9 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10620237", "map_id": "none", "name": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10620157", "map_id": "none", "name": "CLASP proteins:cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10620159", "map_id": "none", "name": "PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10620269", "map_id": "none", "name": "Clathrin recruits PIK3C2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10598852", "map_id": "none", "name": "Homologues of PIK3C2A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10620161", "map_id": "none", "name": "PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10621965", "map_id": "none", "name": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane" }, { "id": "species_10620531", "map_id": "none", "name": "PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10620272", "map_id": "none", "name": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10620432", "map_id": "none", "name": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane" }, { "id": "species_10620425", "map_id": "none", "name": "PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "species_10620429", "map_id": "none", "name": "clathrin:HSPA8:ADP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10621969", "map_id": "none", "name": "Initial binding of AP-2 and clathrin to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10620438", "map_id": "none", "name": "Clathrin recruits auxilins to the clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane" }, { "id": "species_10620331", "map_id": "none", "name": "GAK,DNAJC6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10620434", "map_id": "none", "name": "PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "species_10620436", "map_id": "none", "name": "PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10620443", "map_id": "none", "name": "Dynamin-mediated GTP hydrolysis promotes vesicle scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10620440", "map_id": "none", "name": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane" }, { "id": "reaction_10620316", "map_id": "none", "name": "BAR domain proteins recruit dynamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10620312", "map_id": "none", "name": "DNM:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10620310", "map_id": "none", "name": "PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10601617", "map_id": "none", "name": "SLC17A3-2 transports cytosolic urate to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_429056", "map_id": "CHEBI:17775", "name": "urate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10601614", "map_id": "none", "name": "Homologues of SLC17A3(1-498)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10601536", "map_id": "none", "name": "CLCN4/5/6 exchange Cl- for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2731008", "map_id": "CHEBI:17996", "name": "Cl-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171907", "compartment_display": "endosome lumen", "complex": "false" }, { "id": "species_10601533", "map_id": "Q1ZXJ0", "name": "clcD", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "false" }, { "id": "DDB_G0278639", "map_id": "DDB_G0278639", "name": "clcD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10627397", "map_id": "none", "name": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10627394", "map_id": "none", "name": "TRPA1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10602358", "map_id": "none", "name": "p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10602360", "map_id": "none", "name": "TRPs transport extracellular Ca2+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602335", "map_id": "none", "name": "TRPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54EY0", "map_id": "Q54EY0", "name": "MCOLN3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291275", "map_id": "DDB_G0291275", "name": "MCOLN3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10601528", "map_id": "none", "name": "ANOs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10601525", "map_id": "none", "name": "ANOs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54BH1", "map_id": "Q54BH1", "name": "ANO2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293626", "map_id": "DDB_G0293626", "name": "ANO2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GA1", "map_id": "Q55GA1", "name": "ANO2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10601608", "map_id": "none", "name": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10601605", "map_id": "none", "name": "CLCN1/2/KA/KB", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54C67", "map_id": "Q54C67", "name": "clcF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293130", "map_id": "DDB_G0293130", "name": "clcF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LQ4", "map_id": "Q54LQ4", "name": "clcE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286491", "map_id": "DDB_G0286491", "name": "clcE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10601626", "map_id": "none", "name": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2892454", "map_id": "CHEBI:29101", "name": "Na+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10601623", "map_id": "none", "name": "Homologues of SLC17A3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10627086", "map_id": "none", "name": "ANO1 transports cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10601485", "map_id": "none", "name": "Homologues of ANO1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10592547", "map_id": "none", "name": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_140912", "map_id": "CHEBI:28938", "name": "NH4+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10592822", "map_id": "none", "name": "RhCG mediates ammonium efflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10592535", "map_id": "none", "name": "Homologues of RHCG", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10592552", "map_id": "none", "name": "RhBG mediates ammonium effflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10592549", "map_id": "Q8I0L6", "name": "rhgB", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10592824", "map_id": "none", "name": "RhBG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10592538", "map_id": "none", "name": "RhCG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10592523", "map_id": "none", "name": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_432019", "map_id": "CHEBI:16199", "name": "Urea", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10592520", "map_id": "none", "name": "Urea transporters", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q86AP4", "map_id": "Q86AP4", "name": "SLC14A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277263", "map_id": "DDB_G0277263", "name": "SLC14A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10591788", "map_id": "none", "name": "HMIT co-transports myo-inositol with a proton", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_429130", "map_id": "CHEBI:17268", "name": "Ins", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10591785", "map_id": "Q54YF6", "name": "SLC2A13", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0278261", "map_id": "DDB_G0278261", "name": "SLC2A13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10592375", "map_id": "none", "name": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_172574", "compartment_display": "late endosome membrane" }, { "id": "species_445829", "map_id": "none", "name": "Divalent metals transported by NRAMP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_445832", "map_id": "none", "name": "Divalent metals transported by NRAMP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "true" }, { "id": "species_1470067", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "species_10592372", "map_id": "Q869V1", "name": "nramp1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_172574", "compartment_display": "late endosome membrane", "complex": "false" }, { "id": "DDB_G0276973", "map_id": "DDB_G0276973", "name": "nramp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10592422", "map_id": "none", "name": "SLC31A1 transports Cu2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_209799", "map_id": "CHEBI:29036", "name": "Cu2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10592419", "map_id": "Q54N27", "name": "SLC31A1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0285545", "map_id": "DDB_G0285545", "name": "SLC31A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10624126", "map_id": "none", "name": "SLC30A10 transports Mn2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29418", "map_id": "CHEBI:29035", "name": "Mn2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10624123", "map_id": "Q54T06", "name": "SLC30A10", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10592380", "map_id": "none", "name": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_435347", "map_id": "CHEBI:29033", "name": "Fe2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10592377", "map_id": "Q869V1", "name": "nramp1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10592367", "map_id": "none", "name": "MATEs mediate extrusion of xenobiotics", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_446589", "map_id": "none", "name": "MATE substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:8428", "map_id": "CHEBI:8428", "name": "CHEBI:8428", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:46020", "map_id": "CHEBI:46020", "name": "CHEBI:46020", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:42820", "map_id": "CHEBI:42820", "name": "CHEBI:42820", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:641", "map_id": "CHEBI:641", "name": "CHEBI:641", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:6801", "map_id": "CHEBI:6801", "name": "CHEBI:6801", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16737", "map_id": "CHEBI:16737", "name": "CHEBI:16737", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_446597", "map_id": "none", "name": "MATE substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10592364", "map_id": "none", "name": "MATE1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54YM8", "map_id": "Q54YM8", "name": "SLC47A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292132", "map_id": "DDB_G0292132", "name": "SLC47A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DM2", "map_id": "Q54DM2", "name": "SLC47A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10594911", "map_id": "none", "name": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10594907", "map_id": "none", "name": "Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10594881", "map_id": "Q54I89", "name": "upf1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0288923", "map_id": "DDB_G0288923", "name": "phospho-upf1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10594909", "map_id": "none", "name": "UPF1:eRF3 Complex on Translated mRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54I89", "map_id": "Q54I89", "name": "phospho-upf1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10594987", "map_id": "none", "name": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10594982", "map_id": "none", "name": "SMG1:UPF1:EJC:Translated mRNP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54R12", "map_id": "Q54R12", "name": "SMG9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283447", "map_id": "DDB_G0283447", "name": "SMG9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q75JP6", "map_id": "Q75JP6", "name": "SMG8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272470", "map_id": "DDB_G0272470", "name": "SMG8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TQ1", "map_id": "Q54TQ1", "name": "UPF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281623", "map_id": "DDB_G0281623", "name": "UPF2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10594984", "map_id": "none", "name": "SMG1:Phosphorylated UPF1:EJC:Translated mRNP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10582497", "map_id": "none", "name": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10582491", "map_id": "none", "name": "TFIIIC:Type 2 Promoter Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10581800", "map_id": "none", "name": "TFIIIB-Type 1 and 2 Promoter Selective Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10582495", "map_id": "none", "name": "TFIIIB:TFIIIC:Type 2 Promoter Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10582501", "map_id": "none", "name": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10582499", "map_id": "none", "name": "RNA Polymerase III:TFIIIB:TFIIIC:Type 2 Promoter Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10582493", "map_id": "none", "name": "Binding of TFIIIC to Type 2 promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10581829", "map_id": "none", "name": "TFIIIC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_83747", "map_id": "none", "name": "DNA with RNA Polymerase III Type 2 Closed Promoter", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10588590", "map_id": "none", "name": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10588141", "map_id": "none", "name": "RAC1:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10588587", "map_id": "none", "name": "GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q550V3", "map_id": "Q550V3", "name": "ARHGEF18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277017", "map_id": "DDB_G0277017", "name": "ARHGEF18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MM3", "map_id": "Q54MM3", "name": "ARHGEF9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291085", "map_id": "DDB_G0291085", "name": "ARHGEF9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54B37", "map_id": "Q54B37", "name": "gxcJ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293978", "map_id": "DDB_G0293978", "name": "gxcJ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54F64", "map_id": "Q54F64", "name": "ARHGEF9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PK2", "map_id": "Q54PK2", "name": "ARHGEF9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXN6", "map_id": "Q1ZXN6", "name": "gxcM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272372", "map_id": "DDB_G0272372", "name": "gxcM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54J11", "map_id": "Q54J11", "name": "gxcI", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288383", "map_id": "DDB_G0288383", "name": "gxcI", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10626822", "map_id": "none", "name": "pro-RAS proteins are farnesylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10626748", "map_id": "none", "name": "pro-RAS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_2530486", "map_id": "CHEBI:50277", "name": "FPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10626810", "map_id": "none", "name": "S-Farn-proRAS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10626817", "map_id": "none", "name": "FNTA:FNTB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54RT9", "map_id": "Q54RT9", "name": "fntA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283053", "map_id": "DDB_G0283053", "name": "fntA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55D51", "map_id": "Q55D51", "name": "fntB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270948", "map_id": "DDB_G0270948", "name": "fntB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10626820", "map_id": "none", "name": "FNTA:FNTB:FTase inhibitors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10626891", "map_id": "none", "name": "mature RAS proteins translocate to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10626887", "map_id": "none", "name": "S-Farn-Me PalmS KRAS4A,HRAS, NRAS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10626889", "map_id": "none", "name": "S-Farn-Me-PalmS KRAS4A, HRAS, NRAS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10626920", "map_id": "none", "name": "Palmostatin B binds RAS depalmitoylases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9647934", "map_id": "none", "name": "Palmostatin B", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10626916", "map_id": "none", "name": "LYPLA1 dimer, ABHD17A,B,C", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54F01", "map_id": "Q54F01", "name": "ABHD17C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291205", "map_id": "DDB_G0291205", "name": "ABHD17C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10626918", "map_id": "none", "name": "Palmostatin B:LYPLA1 dimer, ABHD17A,B,C", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10626990", "map_id": "none", "name": "KRAS4B is phosphorylated on serine 181", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10585140", "map_id": "none", "name": "Homologues of S-Farn-Me KRAS4B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10626983", "map_id": "none", "name": "Homologues of pS181-S-Farn-Me KRAS4B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10626987", "map_id": "none", "name": "PRKG2 dimer:cGMP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10626925", "map_id": "none", "name": "RAS proteins are depalmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10626922", "map_id": "none", "name": "S-Farn-Me KRAS4A, HRAS, NRAS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_8848337", "map_id": "CHEBI:7896", "name": "PALM(-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10626930", "map_id": "none", "name": "mature p21 RAS binds GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10585142", "map_id": "none", "name": "mature p21 RAS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10626994", "map_id": "none", "name": "S-Farn-Me KRAS4B binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10626992", "map_id": "none", "name": "S-Farn-Me KRAS4B:CALM1:4xCa2+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10627027", "map_id": "none", "name": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10627025", "map_id": "none", "name": "Homologues of pS181-S-Farn-Me KRAS4B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10626928", "map_id": "none", "name": "Mature S-Farn-Me KRAS4B translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10626679", "map_id": "none", "name": "Homologues of S-Farn-Me KRAS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10626903", "map_id": "none", "name": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10626681", "map_id": "none", "name": "S-Farn-Me RAS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10626900", "map_id": "none", "name": "ZDHHC9:GOLGA7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q54RL6", "map_id": "Q54RL6", "name": "ZDHHC9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283039", "map_id": "DDB_G0283039", "name": "ZDHHC9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q550I3", "map_id": "Q550I3", "name": "GOLGA7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277093", "map_id": "DDB_G0277093", "name": "GOLGA7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10627061", "map_id": "none", "name": "Calmodulin dissociates KRAS4B from the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10627059", "map_id": "none", "name": "S-Farn-Me KRAS4B:CALM1:4xCa2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10626905", "map_id": "none", "name": "FNTB inhibitors bind FNTA:FNTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9653479", "map_id": "none", "name": "FNTB inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10626685", "map_id": "none", "name": "ICMT methylates S-Farn RAS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10626649", "map_id": "none", "name": "S-Farn-RAS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10626683", "map_id": "none", "name": "ICMT:Zn2+:Cysmethynil", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10607347", "map_id": "none", "name": "PEBP1 binds activated RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10607343", "map_id": "Q54QK0", "name": "PEBP1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0283803", "map_id": "DDB_G0283803", "name": "PEBP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10607338", "map_id": "none", "name": "p21RAS:GTP:activated RAF1 homo/heterodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10607345", "map_id": "none", "name": "p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54QK0", "map_id": "Q54QK0", "name": "PEBP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10607267", "map_id": "none", "name": "BRAP binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10607263", "map_id": "Q55C68", "name": "BRAP", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0270200", "map_id": "DDB_G0270200", "name": "Q55C68", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10607265", "map_id": "none", "name": "p21 RAS:GTP:BRAP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q55C68", "map_id": "Q55C68", "name": "Q55C68", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10607319", "map_id": "none", "name": "PAQR3 binds inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10606974", "map_id": "Q54TM7", "name": "phospho-drkD", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10607315", "map_id": "none", "name": "Homologues of PAQR3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q54FT1", "map_id": "Q54FT1", "name": "PAQR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293838", "map_id": "DDB_G0293838", "name": "PAQR3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54B86", "map_id": "Q54B86", "name": "PAQR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54CB4", "map_id": "Q54CB4", "name": "PAQR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10607317", "map_id": "none", "name": "PAQR3:inactive RAFs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10607367", "map_id": "none", "name": "PP5 dephosphorylates RAF1 S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10607351", "map_id": "none", "name": "p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10607364", "map_id": "Q54RH6", "name": "PPP5C", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0283157", "map_id": "DDB_G0283157", "name": "PPP5C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10607271", "map_id": "none", "name": "BRAP binds KSR1:MARK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10606927", "map_id": "none", "name": "KSR1:MARK3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10607269", "map_id": "none", "name": "BRAP:KSR1:MARK3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10607279", "map_id": "none", "name": "BRAP autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10607276", "map_id": "none", "name": "p21 RAS:GTP:ub-BRAP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10607358", "map_id": "none", "name": "PP2A dephosphorylates RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10607355", "map_id": "none", "name": "p21RAS:GTP:p-S621 RAF1 homo/heterodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10607330", "map_id": "Q54TM7", "name": "phospho-drkD", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10626932", "map_id": "none", "name": "Intrinsic nucleotide exchange on RAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10627146", "map_id": "none", "name": "RAS:GTP binds RAL GDS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10627140", "map_id": "none", "name": "RAL GDS proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10627142", "map_id": "none", "name": "S-Farn-Me-2xPalmS HRAS:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10627144", "map_id": "none", "name": "S-Farn-Me_2xPalmS HRAS:GTP:RAL GDS proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10626937", "map_id": "none", "name": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10607066", "map_id": "none", "name": "RAS GEFs promote RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10607063", "map_id": "none", "name": "RAS GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10626939", "map_id": "none", "name": "Raf dimer inhibitors bind RAF heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10607149", "map_id": "none", "name": "p21 RAS:GTP:homo/heterodimerized RAF complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_9657579", "map_id": "none", "name": "RAF dimer inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10606970", "map_id": "none", "name": "MARK3 phosphorylates KSR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10606967", "map_id": "none", "name": "p-S311,S406 KSR1:MARK3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10606562", "map_id": "none", "name": "KBTBD7:CUL3:RBX1 ubiquitinates NF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10606525", "map_id": "none", "name": "SPRED dimer:NF1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q5TJ65", "map_id": "Q5TJ65", "name": "vasp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289541", "map_id": "DDB_G0289541", "name": "vasp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WD0", "map_id": "Q54WD0", "name": "SYNGAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282941", "map_id": "DDB_G0282941", "name": "SYNGAP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Y08", "map_id": "Q54Y08", "name": "ngap", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278483", "map_id": "DDB_G0278483", "name": "ngap", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AR6", "map_id": "Q55AR6", "name": "nfaA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271750", "map_id": "DDB_G0271750", "name": "nfaA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86JJ7", "map_id": "Q86JJ7", "name": "SYNGAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8SSU4", "map_id": "Q8SSU4", "name": "SYNGAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RT3", "map_id": "Q54RT3", "name": "SYNGAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10606557", "map_id": "none", "name": "SPRED dimer:ub-NF1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10606559", "map_id": "none", "name": "KBTBD7:CUL3:RBX1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10606532", "map_id": "none", "name": "RAS GAPs stimulate RAS GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10606529", "map_id": "none", "name": "p21 RAS:GTP:RAS GAPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10606527", "map_id": "none", "name": "RAS GAPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10606564", "map_id": "none", "name": "NF1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10606507", "map_id": "none", "name": "SPRED dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10606566", "map_id": "none", "name": "RAS GAPs bind RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10606568", "map_id": "none", "name": "SPRED dimer binds NF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10606523", "map_id": "none", "name": "Homologues of NF1(2-2839)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10583296", "map_id": "none", "name": "Resumption of elongation after recovery from pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10583294", "map_id": "none", "name": "Paused processive elongation complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10583300", "map_id": "none", "name": "Abortive termination of elongation after arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10583298", "map_id": "none", "name": "Aborted elongation complex after arrest", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10581640", "map_id": "none", "name": "Fall Back to Closed Pre-initiation Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10581740", "map_id": "none", "name": "Abortive Initiation After Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10581738", "map_id": "none", "name": "pol II transcription complex containing 4-9 nucleotide long transcript", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_75897", "map_id": "none", "name": "template DNA:4-9 nucleotide transcript hybrid", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10583308", "map_id": "none", "name": "Formation of FACT complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10583209", "map_id": "Q54S43", "name": "spt16", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10583204", "map_id": "Q54G78", "name": "ssrp1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10583310", "map_id": "none", "name": "Formation of P-TEFb complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10583129", "map_id": "Q556Z2", "name": "CDK9", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10583140", "map_id": "none", "name": "CCNT1,CCNT2,CCNK", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10583142", "map_id": "none", "name": "P-TEFb complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10583312", "map_id": "none", "name": "Formation of DSIF complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10583163", "map_id": "Q54NF2", "name": "spt4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10583316", "map_id": "none", "name": "Abortive termination of early transcription elongation by DSIF:NELF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10583219", "map_id": "none", "name": "DSIF:NELF:early elongation complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10583318", "map_id": "none", "name": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10583322", "map_id": "none", "name": "TFIIS-mediated recovery of elongation from arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10581628", "map_id": "none", "name": "Abortive Initiation Before Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10581626", "map_id": "none", "name": "Pol II Promoter Escape Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_110068", "map_id": "none", "name": "DNA containing Pol II promoter with transcript with 2 or 3 nucleotides", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10583324", "map_id": "none", "name": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10580926", "map_id": "none", "name": "Abortive initiation after formation of the first phosphodiester bond", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_109877", "map_id": "none", "name": "template DNA with first transcript dinucleotide, opened to +8 position", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10626417", "map_id": "none", "name": "SESN1,2 binds L-leucine and dissociates from GATOR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10626411", "map_id": "none", "name": "KICSTOR:GATOR1:GATOR2:SESN1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "Q86K39", "map_id": "Q86K39", "name": "SEH1L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277257", "map_id": "DDB_G0277257", "name": "SEH1L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JS5", "map_id": "Q54JS5", "name": "wdr24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287817", "map_id": "DDB_G0287817", "name": "wdr24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DS4", "map_id": "Q54DS4", "name": "WDR59", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292056", "map_id": "DDB_G0292056", "name": "WDR59", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q551B5", "map_id": "Q551B5", "name": "mios", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276673", "map_id": "DDB_G0276673", "name": "mios", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XA2", "map_id": "Q54XA2", "name": "DEPDC5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279099", "map_id": "DDB_G0279099", "name": "DEPDC5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BD9", "map_id": "Q55BD9", "name": "NPRL2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271288", "map_id": "DDB_G0271288", "name": "NPRL2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54UN5", "map_id": "Q54UN5", "name": "NPRL3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280947", "map_id": "DDB_G0280947", "name": "NPRL3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NW3", "map_id": "Q54NW3", "name": "KPTN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284957", "map_id": "DDB_G0284957", "name": "KPTN", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Y15", "map_id": "Q54Y15", "name": "C12orf66", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278475", "map_id": "DDB_G0278475", "name": "C12orf66", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86IH5", "map_id": "Q86IH5", "name": "SZT2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272696", "map_id": "DDB_G0272696", "name": "SZT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DE8", "map_id": "Q55DE8", "name": "ITFG2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269680", "map_id": "DDB_G0269680", "name": "ITFG2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10626413", "map_id": "none", "name": "KICSTOR:GATOR1:GATOR2", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10626415", "map_id": "none", "name": "SESN1,2:L-Leu", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10626343", "map_id": "none", "name": "RRAGC,D exchanges GTP for GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10626336", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10626340", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10626535", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10626423", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10584177", "map_id": "none", "name": "mTORC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10626430", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10626532", "map_id": "none", "name": "RRAGC,D hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10626530", "map_id": "none", "name": "FLCN:FNIP1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54HT9", "map_id": "Q54HT9", "name": "FNIP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289243", "map_id": "DDB_G0289243", "name": "FNIP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54UF2", "map_id": "Q54UF2", "name": "FLCN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281111", "map_id": "DDB_G0281111", "name": "FLCN", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10626457", "map_id": "none", "name": "RRAGA,B hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10626432", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10626434", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10626449", "map_id": "none", "name": "KICSTOR:GATOR1:BMT2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10626455", "map_id": "none", "name": "KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10626445", "map_id": "none", "name": "KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10626543", "map_id": "none", "name": "mTORC1 binds RHEB:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10584158", "map_id": "none", "name": "RHEB:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10626428", "map_id": "none", "name": "RRAGA,B exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10626421", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10626425", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10606133", "map_id": "none", "name": "GLI2,3 are degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10606131", "map_id": "none", "name": "ub-2p-GLI2,3:SPOP:CUL3:RBX1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54D90", "map_id": "Q54D90", "name": "SPOP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292428", "map_id": "DDB_G0292428", "name": "SPOP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WU7", "map_id": "Q54WU7", "name": "SPOP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55E93", "map_id": "Q55E93", "name": "bzpE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269338", "map_id": "DDB_G0269338", "name": "bzpE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10606129", "map_id": "none", "name": "SPOP:CUL3:RBX1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10606140", "map_id": "none", "name": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10606137", "map_id": "none", "name": "2p-GLI:SPOP:CUL3:RBX1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10595044", "map_id": "none", "name": "ISGylation of DDX58", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10595040", "map_id": "none", "name": "ISG15:UBEIL/UbcH8:CEB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10595042", "map_id": "none", "name": "ISG15:DDX58 conjugate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10605345", "map_id": "none", "name": "SYVN1 ubiquitinates Hh C-terminal fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10605338", "map_id": "none", "name": "C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q86H64", "map_id": "Q86H64", "name": "ERLEC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275851", "map_id": "DDB_G0275851", "name": "ERLEC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IC9", "map_id": "Q54IC9", "name": "derl1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288833", "map_id": "DDB_G0288833", "name": "derl1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JQ6", "map_id": "Q54JQ6", "name": "SYVN1(1-617)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287847", "map_id": "DDB_G0287847", "name": "SYVN1(1-617)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55E19", "map_id": "Q55E19", "name": "SEL1L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269430", "map_id": "DDB_G0269430", "name": "SEL1L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10605342", "map_id": "none", "name": "ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10593912", "map_id": "none", "name": "Aquaporins passively transport water into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10593909", "map_id": "none", "name": "AQP0,1,2,3,4,5,7,8,9,10,11,12A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54WT8", "map_id": "Q54WT8", "name": "aqpB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279443", "map_id": "DDB_G0279443", "name": "aqpB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10593914", "map_id": "none", "name": "Aquaporins passively transport water out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10587219", "map_id": "none", "name": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10587026", "map_id": "Q556W3", "name": "THEM4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10619666", "map_id": "none", "name": "LYZ binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_6789198", "map_id": "CHEBI:55424", "name": "GlcNac-(1-->4)MurNAc-L-Ala-gamma-D-Glu-L-Lys-(D-Ala)2", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10614528", "map_id": "none", "name": "Homologues of LYZ", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q54F36", "map_id": "Q54F36", "name": "lyC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291137", "map_id": "DDB_G0291137", "name": "lyC2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XV8", "map_id": "Q54XV8", "name": "LYZ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278563", "map_id": "DDB_G0278563", "name": "LYZ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MML4", "map_id": "Q8MML4", "name": "rcdBB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274551", "map_id": "DDB_G0274551", "name": "rcdBB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10619664", "map_id": "none", "name": "LYZ:PGN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10619669", "map_id": "none", "name": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_6788991", "map_id": "none", "name": "MurNAc:Peptide", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222574", "compartment_display": "cell wall", "complex": "true" }, { "id": "CHEBI:21615", "map_id": "CHEBI:21615", "name": "CHEBI:21615", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_6788982", "map_id": "CHEBI:28009", "name": "betaGlcNAc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222574", "compartment_display": "cell wall", "complex": "false" }, { "id": "reaction_10616763", "map_id": "none", "name": "BPI binds LPS on the bacterial surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_6803081", "map_id": "CHEBI:16412", "name": "LPS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222574", "compartment_display": "cell wall", "complex": "false" }, { "id": "species_10616761", "map_id": "none", "name": "BPI:LPS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10603621", "map_id": "none", "name": "NLK translocates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10603605", "map_id": "none", "name": "pT298-NLK dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q554L2", "map_id": "Q554L2", "name": "phospho-p-T298-NLK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280855", "map_id": "DDB_G0280855", "name": "phospho-p-T298-NLK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54V35", "map_id": "Q54V35", "name": "phospho-p-T298-NLK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54V83", "map_id": "Q54V83", "name": "phospho-p-T298-NLK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54US6", "map_id": "Q54US6", "name": "phospho-p-T298-NLK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10603619", "map_id": "none", "name": "pT298-NLK dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10603684", "map_id": "none", "name": "Translocation of NFATC1:CaN:CaM to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10603678", "map_id": "none", "name": "NFATC1:CaN:CaM", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10603682", "map_id": "none", "name": "NFATC1:CaN:CaM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10603543", "map_id": "none", "name": "PDE6 hydrolyses cGMP to GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10603540", "map_id": "none", "name": "GNAT2:PDE6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10622131", "map_id": "none", "name": "SLC26A11 transports SO4(2-) from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10622128", "map_id": "Q55FJ8", "name": "SLC26A11", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0268074", "map_id": "DDB_G0268074", "name": "SLC26A11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10591543", "map_id": "none", "name": "SLC26A3,6 exchange Cl- for HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10591540", "map_id": "none", "name": "SLC26A3,6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10591526", "map_id": "none", "name": "Group 3 - Selective Cl- transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10591523", "map_id": "none", "name": "SLC26 chloride transporters", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10605910", "map_id": "none", "name": "SLC26A4 transports I- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605907", "map_id": "none", "name": "Homologues of SLC26A4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10605187", "map_id": "none", "name": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5673778", "map_id": "CHEBI:16283", "name": "CySS-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_379444", "map_id": "CHEBI:16283", "name": "CySS-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10605184", "map_id": "Q54WT7", "name": "ctns", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "DDB_G0279445", "map_id": "DDB_G0279445", "name": "ctns", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10591393", "map_id": "none", "name": "Na+/H+ exchanger transport (at cell membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10591390", "map_id": "none", "name": "SLC9A1-5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54TB5", "map_id": "Q54TB5", "name": "nhe2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281877", "map_id": "DDB_G0281877", "name": "nhe2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q552S0", "map_id": "Q552S0", "name": "nhe1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275711", "map_id": "DDB_G0275711", "name": "nhe1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10591341", "map_id": "none", "name": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_172574", "compartment_display": "late endosome membrane" }, { "id": "species_425999", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_173031", "compartment_display": "late endosome lumen", "complex": "false" }, { "id": "species_425977", "map_id": "CHEBI:29101", "name": "Na+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_173031", "compartment_display": "late endosome lumen", "complex": "false" }, { "id": "species_10591338", "map_id": "none", "name": "Homologues of SLC9A9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_172574", "compartment_display": "late endosome membrane", "complex": "true" }, { "id": "reaction_10591358", "map_id": "none", "name": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_425978", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171043", "compartment_display": "early endosome lumen", "complex": "false" }, { "id": "species_425971", "map_id": "CHEBI:29101", "name": "Na+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171043", "compartment_display": "early endosome lumen", "complex": "false" }, { "id": "species_10591355", "map_id": "none", "name": "SLC9A6,7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "reaction_10591406", "map_id": "none", "name": "Na+/H+ exchanger transport (at trans-golgi membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_425969", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_425958", "map_id": "CHEBI:29101", "name": "Na+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10591403", "map_id": "none", "name": "SLC9A7/8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10591664", "map_id": "none", "name": "Type I Na+-coupled phosphate co-transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10591661", "map_id": "none", "name": "Homologues of SLC17A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10622115", "map_id": "none", "name": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10622110", "map_id": "Q54RB9", "name": "mcfO", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "reaction_10591574", "map_id": "none", "name": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_201753", "compartment_display": "synaptic vesicle membrane" }, { "id": "species_428548", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20600", "compartment_display": "synaptic vesicle", "complex": "false" }, { "id": "species_428614", "map_id": "CHEBI:29985", "name": "L-Glu", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20600", "compartment_display": "synaptic vesicle", "complex": "false" }, { "id": "species_10591571", "map_id": "none", "name": "SLC17A6,7,8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_201753", "compartment_display": "synaptic vesicle membrane", "complex": "true" }, { "id": "reaction_10593024", "map_id": "none", "name": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10586023", "map_id": "none", "name": "GLUT2 / SLC2A2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10624195", "map_id": "none", "name": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10624192", "map_id": "none", "name": "GLUT4 / SLC2A4 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10591744", "map_id": "none", "name": "GLUT7 and GLUT11 transport glucose and fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_428819", "map_id": "none", "name": "hexoses transported by GLUT7/11", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_428802", "map_id": "none", "name": "hexoses transported by GLUT7/11", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10591741", "map_id": "none", "name": "GLUT7/11", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10591780", "map_id": "none", "name": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10591777", "map_id": "none", "name": "SLC2A6,8,10,12", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54M69", "map_id": "Q54M69", "name": "SLC2A6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286151", "map_id": "DDB_G0286151", "name": "SLC2A6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10624197", "map_id": "none", "name": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10605166", "map_id": "none", "name": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10593015", "map_id": "none", "name": "GLUT1 / SLC2A1 tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10591761", "map_id": "none", "name": "SLC2A9 transports Fru, Glc, urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_429078", "map_id": "none", "name": "Fru,Glc,urate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_429148", "map_id": "none", "name": "Fru,Glc,urate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10591758", "map_id": "none", "name": "Homologues of SLC2A9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10624179", "map_id": "none", "name": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10624176", "map_id": "none", "name": "GLUT14 / SLC2A14 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10593019", "map_id": "none", "name": "GLUT1 tetramer binds 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10593017", "map_id": "none", "name": "GLUT1:ATP tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10624184", "map_id": "none", "name": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10624181", "map_id": "none", "name": "GLUT3 / SLC2A3 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10622136", "map_id": "none", "name": "SLC45A3 transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10622133", "map_id": "Q7KWK4", "name": "SLC45A3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10593021", "map_id": "none", "name": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10622268", "map_id": "none", "name": "SLC50A1 transports Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10622265", "map_id": "Q54JW5", "name": "slc50a1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0287763", "map_id": "DDB_G0287763", "name": "slc50a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10623330", "map_id": "none", "name": "MAF1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10623321", "map_id": "Q54Y76", "name": "maf1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0278673", "map_id": "DDB_G0278673", "name": "phospho-maf1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10623319", "map_id": "Q54Y76", "name": "maf1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10623328", "map_id": "none", "name": "mTORC1 phosphorylates MAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10623326", "map_id": "Q54Y76", "name": "phospho-maf1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10616691", "map_id": "none", "name": "Monoubiquitinated PTEN translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10616685", "map_id": "Q8T9S7", "name": "pteN", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10616689", "map_id": "Q8T9S7", "name": "pteN", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10616696", "map_id": "none", "name": "USP7 deubiquitinates monoubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10616693", "map_id": "Q8T9S7", "name": "pteN", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10602170", "map_id": "Q869U4", "name": "USP7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10616699", "map_id": "none", "name": "Deubiquitinated PTEN translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10618691", "map_id": "none", "name": "Proteasome degrades polyubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618689", "map_id": "none", "name": "PolyUb-PTEN, K48polyUb-K289-PTEN, PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10623382", "map_id": "none", "name": "TNKS and TNKS2 PARylate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10623370", "map_id": "Q8T9S7", "name": "phospho-pteN", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10623379", "map_id": "none", "name": "TNKS1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86J21", "map_id": "Q86J21", "name": "TNKS2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274293", "map_id": "DDB_G0274293", "name": "TNKS2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10618679", "map_id": "none", "name": "Casein kinase II phosphorylates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10618677", "map_id": "Q8T9S7", "name": "phospho-pteN", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10623365", "map_id": "none", "name": "AKT phosphorylates MKRN1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10596354", "map_id": "Q54TM9", "name": "MKRN1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0281657", "map_id": "DDB_G0281657", "name": "MKRN1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10623363", "map_id": "Q54TM9", "name": "phospho-p-S109-MKRN1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10616726", "map_id": "none", "name": "USP13 and OTUD3 deubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10616716", "map_id": "Q8T9S7", "name": "pteN", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10616723", "map_id": "none", "name": "USP13,OTUD3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55FY4", "map_id": "Q55FY4", "name": "OTUD3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10616713", "map_id": "none", "name": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10616702", "map_id": "Q8T9S7", "name": "pteN", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10616710", "map_id": "none", "name": "NEDD4,STUB1,WWP2 and XIAP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10623368", "map_id": "none", "name": "MKRN1 polyubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10593296", "map_id": "none", "name": "BRF1 Complex recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10593226", "map_id": "Q54GU2", "name": "XRN1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0289921", "map_id": "DDB_G0289921", "name": "XRN1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10591881", "map_id": "Q54R87", "name": "dcp2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0283315", "map_id": "DDB_G0283315", "name": "dcp2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10591977", "map_id": "none", "name": "Exosome Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10593284", "map_id": "none", "name": "BRF1:mRNA Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54MG5", "map_id": "Q54MG5", "name": "ZFP36", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285973", "map_id": "DDB_G0285973", "name": "ZFP36", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10591874", "map_id": "Q54KM1", "name": "DCP1A", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0287243", "map_id": "DDB_G0287243", "name": "DCP1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10593294", "map_id": "none", "name": "BRF1:mRNA Degradation Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54KM1", "map_id": "Q54KM1", "name": "DCP1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54R87", "map_id": "Q54R87", "name": "dcp2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GU2", "map_id": "Q54GU2", "name": "XRN1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10593303", "map_id": "none", "name": "Protein Kinase B/Akt phosphorylates BRF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10593300", "map_id": "none", "name": "Phosphorylated BRF1 (Ser92, Ser203):mRNA Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10593305", "map_id": "none", "name": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_450523", "map_id": "none", "name": "mRNA Transcript Targeted by BRF1", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10593282", "map_id": "Q54MG5", "name": "ZFP36L1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10586026", "map_id": "none", "name": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_189246", "map_id": "none", "name": "Fru, Gal, Glc", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:17118", "map_id": "CHEBI:17118", "name": "CHEBI:17118", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_189219", "map_id": "none", "name": "Fru, Gal, Glc", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10586015", "map_id": "none", "name": "SLC2A5 transports fructose from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10586012", "map_id": "none", "name": "Homologues of SLC2A5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10627366", "map_id": "none", "name": "ATP binds MLKL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10604755", "map_id": "none", "name": "(RIPK1:RIPK3)oligomer:4xMLKL", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10627364", "map_id": "none", "name": "(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4x(MLKL:ATP)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10627370", "map_id": "none", "name": "MLKL binds IP4, IP5 and IP6 ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10604761", "map_id": "none", "name": "(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10627368", "map_id": "none", "name": "p-S-RIPK1:p-S199,227-RIPK3 oligomer:4xMLKL:IP6,IP5, IP4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10611280", "map_id": "none", "name": "ATP13A1 transports Mn2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1981162", "map_id": "CHEBI:29035", "name": "Mn2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10611277", "map_id": "Q54CD1", "name": "ctaA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0293004", "map_id": "DDB_G0293004", "name": "ctaA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10595064", "map_id": "none", "name": "ATP7B transports cytosolic Cu2+ to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_936901", "map_id": "CHEBI:29036", "name": "Cu2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10595061", "map_id": "none", "name": "Homologues of ATP7B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q55DN5", "map_id": "Q55DN5", "name": "ATP7B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284141", "map_id": "DDB_G0284141", "name": "ATP7B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Q77", "map_id": "Q54Q77", "name": "ATP7B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q557B5", "map_id": "Q557B5", "name": "ATP7B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10595352", "map_id": "none", "name": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_947588", "map_id": "none", "name": "APLs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_947587", "compartment_display": "cytoplasmic side of plasma membrane", "complex": "true" }, { "id": "species_947594", "map_id": "none", "name": "APLs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_947586", "compartment_display": "external side of plasma membrane", "complex": "true" }, { "id": "species_10595291", "map_id": "none", "name": "P-type ATPases type IV", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q54U08", "map_id": "Q54U08", "name": "ATP11C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281401", "map_id": "DDB_G0281401", "name": "ATP11C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86H52", "map_id": "Q86H52", "name": "ATP8B2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286891", "map_id": "DDB_G0286891", "name": "ATP8B2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q551T0", "map_id": "Q551T0", "name": "ATP8B2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q553A4", "map_id": "Q553A4", "name": "ATP8B2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54L55", "map_id": "Q54L55", "name": "ATP8B2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55E61", "map_id": "Q55E61", "name": "ATP8B2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10611291", "map_id": "none", "name": "ATP13A2 transports cations from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5692450", "map_id": "CHEBI:36916", "name": "cation", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5692484", "map_id": "CHEBI:36916", "name": "cation", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10611288", "map_id": "none", "name": "Homologues of ATP13A2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q54NW5", "map_id": "Q54NW5", "name": "ATP13A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284955", "map_id": "DDB_G0284955", "name": "ATP13A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54P22", "map_id": "Q54P22", "name": "ATP13A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54X63", "map_id": "Q54X63", "name": "ATP13A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10605018", "map_id": "none", "name": "ATP13A4,5 transport divalent ions from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5252122", "map_id": "CHEBI:60240", "name": "divalent metal cation", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_5252016", "map_id": "CHEBI:60240", "name": "divalent metal cation", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10605015", "map_id": "none", "name": "ATP13A4, 5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10600371", "map_id": "none", "name": "MHC class II antigen processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2213225", "map_id": "none", "name": "unfolded antigen", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2213226", "map_id": "none", "name": "MHC class II epitopes", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10600368", "map_id": "none", "name": "Cathepsin", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10605435", "map_id": "none", "name": "KCNK dimers transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605432", "map_id": "none", "name": "KCNK dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10612564", "map_id": "none", "name": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1660541", "compartment_display": "endolysosome membrane" }, { "id": "species_10612534", "map_id": "none", "name": "PCSK9:LDLR:Clathrin:AP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10612562", "map_id": "none", "name": "PCSK9:LDLR:Clathrin:AP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1660541", "compartment_display": "endolysosome membrane", "complex": "true" }, { "id": "reaction_10622308", "map_id": "none", "name": "NPC2 binds CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10622304", "map_id": "none", "name": "Homologues of NPC2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q54SW1", "map_id": "Q54SW1", "name": "NPC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287185", "map_id": "DDB_G0287185", "name": "NPC2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MV4", "map_id": "Q54MV4", "name": "NPC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SZ8", "map_id": "Q54SZ8", "name": "NPC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SW2", "map_id": "Q54SW2", "name": "NPC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54TL9", "map_id": "Q54TL9", "name": "NPC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SZ9", "map_id": "Q54SZ9", "name": "NPC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54KP7", "map_id": "Q54KP7", "name": "NPC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55BL4", "map_id": "Q55BL4", "name": "NPC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YD2", "map_id": "Q54YD2", "name": "NPC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10622306", "map_id": "none", "name": "NPC2:CHOL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10612566", "map_id": "none", "name": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1660541", "compartment_display": "endolysosome membrane" }, { "id": "species_10612560", "map_id": "none", "name": "Clathrin:AP2 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10622314", "map_id": "none", "name": "NPC2 transfers CHOL to NPC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10622310", "map_id": "Q9TVK6", "name": "npcA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "DDB_G0269158", "map_id": "DDB_G0269158", "name": "npcA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10622312", "map_id": "none", "name": "NPC1:CHOL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "Q9TVK6", "map_id": "Q9TVK6", "name": "npcA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10617819", "map_id": "none", "name": "NCEH1 hydrolyzes cholesterol esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10617816", "map_id": "Q54QI3", "name": "NCEH1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10622316", "map_id": "none", "name": "CHOL translocates from lysosome membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10622364", "map_id": "none", "name": "SOAT1,2 transfer acyl group to CHOL forming CHEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8876704", "map_id": "CHEBI:17002", "name": "CHEST", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10622361", "map_id": "none", "name": "SOAT1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q551G5", "map_id": "Q551G5", "name": "SOAT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276523", "map_id": "DDB_G0276523", "name": "SOAT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10619494", "map_id": "none", "name": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10619484", "map_id": "none", "name": "VLDL:PCSK9:Clathrin:AP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10619492", "map_id": "none", "name": "VLDL:PCSK9:Clathrin:AP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10607943", "map_id": "none", "name": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10607908", "map_id": "none", "name": "4xPALM-C-ABCA1 tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10607940", "map_id": "none", "name": "4xPALM-C-p-2S-ABCA1 tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10607945", "map_id": "none", "name": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10607890", "map_id": "none", "name": "4xPALM-C-ABCA1 tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10620000", "map_id": "none", "name": "OMA1 hydrolyses OPA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10619980", "map_id": "none", "name": "Homologues of OPA1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "species_10619992", "map_id": "none", "name": "Homologues of OPA1(88-194)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "species_10619986", "map_id": "none", "name": "Homologues of OPA1(195-960)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "species_10619997", "map_id": "Q54HN7", "name": "OMA1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0289335", "map_id": "DDB_G0289335", "name": "OMA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10604720", "map_id": "none", "name": "RIPK1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10604713", "map_id": "none", "name": "RIPK1:RIPK3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10604715", "map_id": "none", "name": "p-S-RIPK1:RIPK3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10604718", "map_id": "none", "name": "RIPK1:RIPK3:sorafenib, ponatinib, pazopanib", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10604723", "map_id": "none", "name": "RIPK3 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602348", "map_id": "none", "name": "p-S166-RIPK1:p-S199,227-RIPK3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10604757", "map_id": "none", "name": "RIPK1:RIPK3 oligomer binds MLKL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602350", "map_id": "none", "name": "p-S-RIPK1:p-S199,227-RIPK3 oligomer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10604753", "map_id": "Q54TM7", "name": "drkD", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10604759", "map_id": "none", "name": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10605782", "map_id": "none", "name": "MLKL binds PIPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_5620974", "map_id": "none", "name": "PI4P,PI(4,5)P2,PIP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10605771", "map_id": "none", "name": "RIP1:RIP3:MLKL oligomer:PIPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10605780", "map_id": "none", "name": "p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:PDCD6IP:SDCBP", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8T7K0", "map_id": "Q8T7K0", "name": "alxA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275451", "map_id": "DDB_G0275451", "name": "alxA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10604764", "map_id": "none", "name": "RIPK3 phosphorylates MLKL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10600860", "map_id": "none", "name": "PIP3 recruits AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10625796", "map_id": "none", "name": "TYSND1 cleaves TYSND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_10625726", "map_id": "Q54XC3", "name": "TYSND1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "DDB_G0279049", "map_id": "DDB_G0279049", "name": "TYSND1(111-566)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10625791", "map_id": "Q54XC3", "name": "TYSND1(1-110)", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10625793", "map_id": "Q54XC3", "name": "TYSND1(111-566)", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10589960", "map_id": "none", "name": "Phosphorylated AMPK binds AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10587326", "map_id": "none", "name": "p-AMPK heterotrimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10592925", "map_id": "none", "name": "AMPK phosphorylates Raptor in the mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10606321", "map_id": "none", "name": "Rag dimer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10584219", "map_id": "none", "name": "RRAGA, RRAGB:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10584232", "map_id": "none", "name": "RRAGC,RRAGD:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10584234", "map_id": "none", "name": "RagA,B:GTP:RagC,D:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10623826", "map_id": "none", "name": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428011", "map_id": "CHEBI:32682", "name": "L-Arg", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10584238", "map_id": "none", "name": "Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10584160", "map_id": "none", "name": "GTP loading by Rheb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10584156", "map_id": "none", "name": "RHEB:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10606323", "map_id": "none", "name": "Ragulator:Rag dimers:SLC38A9 bind mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10584240", "map_id": "none", "name": "mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10589778", "map_id": "none", "name": "Activated Akt1 phosphorylates AKT1S1 (PRAS40)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10584263", "map_id": "none", "name": "mTORC1:RHEB:GTP:AKT1S1", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10584255", "map_id": "none", "name": "mTORC1:RHEB:GTP:p-T246-AKT1S1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10587569", "map_id": "none", "name": "Homologues of p-T308,S473-AKT1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10606325", "map_id": "none", "name": "Ragulator binds Rag dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10584206", "map_id": "none", "name": "Ragulator", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10584236", "map_id": "none", "name": "Ragulator:RagA,B:GTP:RagC,D:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10584244", "map_id": "none", "name": "Formation of active mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10584272", "map_id": "none", "name": "Phosphorylation of 4E-BP1 by activated mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10584250", "map_id": "none", "name": "eIF4E:4E-BP1-P", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10584259", "map_id": "none", "name": "mTORC1:p-T246-AKT1S1:YWHAB", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10584270", "map_id": "none", "name": "FKBP1A:sirolimus", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10584339", "map_id": "none", "name": "Phosphorylation and activation of eIF4G by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10584337", "map_id": "Q553R3", "name": "phospho-eif4g", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10584299", "map_id": "none", "name": "Homologues of p-S371,T389-RPS6KB1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10627344", "map_id": "none", "name": "FKBP1A binds sirolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9678687", "map_id": "none", "name": "sirolimus", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10584322", "map_id": "none", "name": "Phosphorylation of Ribosomal protein S6 by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10579877", "map_id": "Q54UU3", "name": "rps6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10584319", "map_id": "Q54UU3", "name": "phospho-rps6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10584277", "map_id": "none", "name": "Dissociation of phosphorylated 4EBP1 from eIF4E", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10584248", "map_id": "Q54DU8", "name": "phospho-febA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10584311", "map_id": "none", "name": "mTORC1 phosphorylation of RPS6KB1 (S6K)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10584289", "map_id": "none", "name": "Homologues of RPS6KB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10584344", "map_id": "none", "name": "Phosphorylation and activation of eIF4B by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10584342", "map_id": "Q75K16", "name": "phospho-p-S422-EIF4B", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10584332", "map_id": "none", "name": "Phosphorylation and inactivation of eEF2K by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10584327", "map_id": "Q54SF9", "name": "mhkD", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0282489", "map_id": "DDB_G0282489", "name": "phospho-mhkD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10584330", "map_id": "Q54SF9", "name": "phospho-mhkD", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10606859", "map_id": "none", "name": "mTORC1 phosphorylates AKT1S1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10606856", "map_id": "none", "name": "mTORC1:RHEB:GTP:p-S183,T246-AKT1S1:YWHAB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10606319", "map_id": "none", "name": "Formation of Ragulator complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10584204", "map_id": "Q54QW5", "name": "LAMTOR5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "species_10584189", "map_id": "Q54F59", "name": "mapbpip", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "species_10584184", "map_id": "Q1ZXA8", "name": "LAMTOR1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "species_10584199", "map_id": "Q54DY3", "name": "LAMTOR4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "species_10584194", "map_id": "Q86J23", "name": "LAMTOR3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "reaction_10605537", "map_id": "none", "name": "AKR1C3 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_975599", "map_id": "CHEBI:17336", "name": "atROL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10605363", "map_id": "none", "name": "ADH1A,1C,4 oxidise atROL to atRAL in vitro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605360", "map_id": "none", "name": "ADH1A,1C,4 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10611912", "map_id": "none", "name": "ALDH8A1 oxidises 9cRAL to 9cRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5362565", "map_id": "CHEBI:78273", "name": "9cRAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5362520", "map_id": "CHEBI:50648", "name": "9cRA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10611909", "map_id": "Q54QC5", "name": "ALDH8A1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0283943", "map_id": "DDB_G0283943", "name": "ALDH8A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10605371", "map_id": "none", "name": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605368", "map_id": "Q54BI7", "name": "RDH14", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "DDB_G0293604", "map_id": "DDB_G0293604", "name": "RDH14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10605791", "map_id": "none", "name": "RDH13 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_5623644", "map_id": "CHEBI:16474", "name": "NADPH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_5623648", "map_id": "CHEBI:17898", "name": "atRAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_5623650", "map_id": "CHEBI:18009", "name": "NADP+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_5623649", "map_id": "CHEBI:17336", "name": "atROL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10605788", "map_id": "Q54LM1", "name": "RDH13", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0286575", "map_id": "DDB_G0286575", "name": "RDH13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10605358", "map_id": "none", "name": "ALDHs oxidise atRAL to atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5334816", "map_id": "CHEBI:15367", "name": "atRA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10605355", "map_id": "none", "name": "ALDH1A1,2,3 tetramers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10624618", "map_id": "none", "name": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10624613", "map_id": "none", "name": "MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_1254400", "map_id": "CHEBI:50114", "name": "ESTG", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10624615", "map_id": "none", "name": "MYB gene:hyperphosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10623125", "map_id": "none", "name": "ESTG binds ESR1:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10623113", "map_id": "none", "name": "ESR1:chaperone complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q54WQ9", "map_id": "Q54WQ9", "name": "PPID", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279491", "map_id": "DDB_G0279491", "name": "PPID", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10623115", "map_id": "none", "name": "ESTG:ESR1:chaperone complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10627482", "map_id": "none", "name": "ESTG binds ESR2:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10623119", "map_id": "none", "name": "ESR2:chaperone complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10623121", "map_id": "none", "name": "ESTG:ESR2:chaperone complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10598291", "map_id": "none", "name": "DVL is ubiquitinated by CUL3:KLHL12:RBX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10598284", "map_id": "none", "name": "DVL:CUL3:KLHL12:RBX1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10598288", "map_id": "none", "name": "ub-DVL:CUL3:KLHL12:RBX1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10598293", "map_id": "none", "name": "Ubiquitinated DVL is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10598280", "map_id": "none", "name": "CUL3:KLHL12:RBX1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10602277", "map_id": "none", "name": "Retromer recycles WLS to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10602271", "map_id": "none", "name": "WLS:retromer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "Q54C24", "map_id": "Q54C24", "name": "vps35", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293218", "map_id": "DDB_G0293218", "name": "vps35", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55CA0", "map_id": "Q55CA0", "name": "vps26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269168", "map_id": "DDB_G0269168", "name": "vps26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IF7", "map_id": "Q54IF7", "name": "vps29", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288787", "map_id": "DDB_G0288787", "name": "vps29", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54UN7", "map_id": "Q54UN7", "name": "SNX3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280921", "map_id": "DDB_G0280921", "name": "SNX3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10602275", "map_id": "none", "name": "WLS:retromer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10600819", "map_id": "none", "name": "PDPK1 binds PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10600817", "map_id": "none", "name": "PDPK1:PIP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10596961", "map_id": "none", "name": "DOCKs bind to RhoGEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10596957", "map_id": "none", "name": "DOCK-GEFs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54CA8", "map_id": "Q54CA8", "name": "DOCK11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293084", "map_id": "DDB_G0293084", "name": "DOCK11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q554I8", "map_id": "Q554I8", "name": "DOCK11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55EI2", "map_id": "Q55EI2", "name": "DOCK11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86I66", "map_id": "Q86I66", "name": "DOCK11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10590248", "map_id": "P34144", "name": "rac1A", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10596959", "map_id": "none", "name": "DOCK-GEFs:RAC1, CDC42", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10596720", "map_id": "none", "name": "Kinesin-7 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10596682", "map_id": "Q54NP8", "name": "kif4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0285101", "map_id": "DDB_G0285101", "name": "kif4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10596684", "map_id": "none", "name": "CENP-E dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54NP8", "map_id": "Q54NP8", "name": "kif4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10596718", "map_id": "none", "name": "Kinesin-5 is a homotetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10596668", "map_id": "Q6RZZ9", "name": "kif13", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0288361", "map_id": "DDB_G0288361", "name": "kif13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10596670", "map_id": "none", "name": "Kinesin-5 homotetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q6RZZ9", "map_id": "Q6RZZ9", "name": "kif13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10596740", "map_id": "none", "name": "HP1 alpha binds Histone H3K9(me)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10596728", "map_id": "none", "name": "Homologues of CBX5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10596736", "map_id": "none", "name": "Histone H3 methylated at lysine-9", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10596738", "map_id": "none", "name": "HP1alpha:Histone H3 methylated at K9", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10596807", "map_id": "none", "name": "LRRC16A binds F-actin capping protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10594244", "map_id": "none", "name": "F-actin capping protein", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10596803", "map_id": "none", "name": "Homologues of LRRC16A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q95VZ3", "map_id": "Q95VZ3", "name": "carmil", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292386", "map_id": "DDB_G0292386", "name": "carmil", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LE3", "map_id": "Q54LE3", "name": "LRRC16A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293920", "map_id": "DDB_G0293920", "name": "LRRC16A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SR9", "map_id": "Q54SR9", "name": "LRRC16A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54B43", "map_id": "Q54B43", "name": "LRRC16A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YK2", "map_id": "Q54YK2", "name": "LRRC16A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54B76", "map_id": "Q54B76", "name": "LRRC16A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54MF0", "map_id": "Q54MF0", "name": "LRRC16A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NS2", "map_id": "Q54NS2", "name": "LRRC16A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KWW4", "map_id": "Q7KWW4", "name": "LRRC16A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54G18", "map_id": "Q54G18", "name": "gacW", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290439", "map_id": "DDB_G0290439", "name": "gacW", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10596805", "map_id": "none", "name": "LRRC16A:F-actin capping protein", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10600822", "map_id": "none", "name": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10596745", "map_id": "Q55D87", "name": "ITPK1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10594246", "map_id": "none", "name": "F-actin capping protein is a heterodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10594237", "map_id": "P13022", "name": "acpB", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10594242", "map_id": "P13021", "name": "acpA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10619768", "map_id": "none", "name": "MICAL1 produces NADP+, H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10619765", "map_id": "none", "name": "MICAL1:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54FV6", "map_id": "Q54FV6", "name": "MICAL1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293708", "map_id": "DDB_G0293708", "name": "MICAL1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54BL7", "map_id": "Q54BL7", "name": "MICAL1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10596826", "map_id": "none", "name": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10596823", "map_id": "Q54CT8", "name": "adkB", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10596748", "map_id": "none", "name": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10596751", "map_id": "none", "name": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10587611", "map_id": "none", "name": "Translocation of PDK1 to Plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_202277", "map_id": "none", "name": "PIP3, PI(3,4)P2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10587609", "map_id": "none", "name": "PDK1:PIP2,PIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10626100", "map_id": "none", "name": "SGTA binds Tail-anchored protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10626061", "map_id": "none", "name": "SGTA dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54VG4", "map_id": "Q54VG4", "name": "sgt", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280345", "map_id": "DDB_G0280345", "name": "sgt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10626096", "map_id": "none", "name": "Tail-anchored proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q553P6", "map_id": "Q553P6", "name": "serp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275381", "map_id": "DDB_G0275381", "name": "serp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54YR4", "map_id": "Q54YR4", "name": "sec61b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278117", "map_id": "DDB_G0278117", "name": "sec61b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LP7", "map_id": "Q54LP7", "name": "ube2j2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286511", "map_id": "DDB_G0286511", "name": "ube2j2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XS7", "map_id": "Q54XS7", "name": "VAPA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278773", "map_id": "DDB_G0278773", "name": "VAPA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JV6", "map_id": "Q54JV6", "name": "sec61g", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287777", "map_id": "DDB_G0287777", "name": "sec61g", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10626098", "map_id": "none", "name": "Tail-anchored protein:SGTA dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10626164", "map_id": "none", "name": "SGTA binds mislocalized membrane protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10626092", "map_id": "none", "name": "Homologues of VAMP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10626162", "map_id": "none", "name": "Mislocalized membrane protein:SGTA dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10625730", "map_id": "none", "name": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10625710", "map_id": "none", "name": "PEX5S,L:Cargo:PEX13:PEX14:PEX2:PEX10:PEX12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "Q54XC3", "map_id": "Q54XC3", "name": "TYSND1(111-566)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54US8", "map_id": "Q54US8", "name": "PIPOX", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GK8", "map_id": "Q54GK8", "name": "MLYCD(40-493)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KWR0", "map_id": "Q7KWR0", "name": "NUDT7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276281", "map_id": "DDB_G0276281", "name": "NUDT7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54SS0", "map_id": "Q54SS0", "name": "ech1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282261", "map_id": "DDB_G0282261", "name": "ech1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GC2", "map_id": "Q54GC2", "name": "NUDT19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JQ2", "map_id": "Q54JQ2", "name": "IDE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287851", "map_id": "DDB_G0287851", "name": "IDE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54FR4", "map_id": "Q54FR4", "name": "PXMP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290631", "map_id": "DDB_G0290631", "name": "PXMP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10625728", "map_id": "none", "name": "Cargo proteins containing PTS1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10625798", "map_id": "none", "name": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10625736", "map_id": "none", "name": "PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "Q54WA3", "map_id": "Q54WA3", "name": "pex7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279801", "map_id": "DDB_G0279801", "name": "pex7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10625738", "map_id": "none", "name": "PEX2:PEX10:PEX12:PEX5L:Ub:UBE2D1,2,3:PEX7:PEX13:PEX14", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10625732", "map_id": "none", "name": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10625708", "map_id": "none", "name": "PEX13:PEX14:PEX2:PEX10:PEX12", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "species_10625706", "map_id": "none", "name": "PEX5S,L:Cargo protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10625643", "map_id": "none", "name": "PEX7 binds cargo proteins containing PTS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10625628", "map_id": "Q54WA3", "name": "pex7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10625639", "map_id": "none", "name": "Cargo proteins containing PTS2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O96759", "map_id": "O96759", "name": "eapA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286183", "map_id": "DDB_G0286183", "name": "eapA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86IY4", "map_id": "Q86IY4", "name": "ACAA1(1-424)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10625641", "map_id": "none", "name": "PEX7:Cargo proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10625752", "map_id": "none", "name": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10625749", "map_id": "none", "name": "USP9X:Ub:PEX5L", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10619197", "map_id": "Q553T4", "name": "USP9X", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10625704", "map_id": "Q54MD1", "name": "pex5", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10625743", "map_id": "none", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10625740", "map_id": "none", "name": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10625775", "map_id": "none", "name": "USP9X binds Ub:PEX5L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10625747", "map_id": "none", "name": "Ub:PEX5L", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10625789", "map_id": "none", "name": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10625779", "map_id": "none", "name": "PEX5L:PEX7:Cargo:PEX13:PEX14:PEX2:PEX10:PEX12", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "species_10625787", "map_id": "none", "name": "Cargo proteins containing PTS2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10625927", "map_id": "none", "name": "PEX3:PEX19:class I PMP dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10625899", "map_id": "none", "name": "PEX3:PEX19:class I PMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "Q54U86", "map_id": "Q54U86", "name": "pex3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ZX5", "map_id": "Q54ZX5", "name": "PXMP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GD8", "map_id": "Q54GD8", "name": "PXMP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54XX9", "map_id": "Q54XX9", "name": "PXMP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FL0", "map_id": "Q55FL0", "name": "PXMP4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268564", "map_id": "DDB_G0268564", "name": "PXMP4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54VX0", "map_id": "Q54VX0", "name": "FIS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280367", "map_id": "DDB_G0280367", "name": "FIS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86AC7", "map_id": "Q86AC7", "name": "PEX11B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276913", "map_id": "DDB_G0276913", "name": "PEX11B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54H86", "map_id": "Q54H86", "name": "pex11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289623", "map_id": "DDB_G0289623", "name": "pex11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q76P23", "map_id": "Q76P23", "name": "mcfQ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXK7", "map_id": "Q1ZXK7", "name": "ATAD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276169", "map_id": "DDB_G0276169", "name": "ATAD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q550G0", "map_id": "Q550G0", "name": "pex16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277113", "map_id": "DDB_G0277113", "name": "pex16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10625925", "map_id": "none", "name": "Class I Peroxisomal Membrane Proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10625931", "map_id": "none", "name": "PEX19 binds class I peroxisomal membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10625895", "map_id": "none", "name": "Class I Peroxisomal Membrane Proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10625897", "map_id": "none", "name": "PEX19:class I PMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10625929", "map_id": "none", "name": "PEX19:class I PMP binds PEX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "reaction_10604817", "map_id": "none", "name": "ADD1:ADD3 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10604813", "map_id": "none", "name": "ADD1:ADD3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54T47", "map_id": "Q54T47", "name": "ADD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282009", "map_id": "DDB_G0282009", "name": "ADD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10604805", "map_id": "Q54WT5", "name": "DMTN", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0279449", "map_id": "DDB_G0279449", "name": "DMTN", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10604815", "map_id": "none", "name": "ADD1:ADD3:DMTN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54WT5", "map_id": "Q54WT5", "name": "DMTN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10605174", "map_id": "none", "name": "TUSC3 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_114632", "map_id": "CHEBI:18420", "name": "Mg2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10605171", "map_id": "Q54N33", "name": "ost3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "DDB_G0285537", "map_id": "DDB_G0285537", "name": "ost3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10604809", "map_id": "none", "name": "ADD1:ADD2 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10604800", "map_id": "none", "name": "ADD1:ADD2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10604807", "map_id": "none", "name": "ADD1:ADD2:DMTN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10605163", "map_id": "none", "name": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605160", "map_id": "Q553K8", "name": "MRS2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "DDB_G0275813", "map_id": "DDB_G0275813", "name": "MRS2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10605179", "map_id": "none", "name": "MAGT1 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10605176", "map_id": "Q54N33", "name": "ost3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10582416", "map_id": "none", "name": "Methylation of GMP-cap by RNA Methyltransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10582409", "map_id": "none", "name": "Capping complex (with freed 5'- GMP)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10582413", "map_id": "none", "name": "mRNA capping factors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10578881", "map_id": "none", "name": "RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10582402", "map_id": "none", "name": "Formation of the CE:GMP intermediate complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10582392", "map_id": "none", "name": "Capping complex (hydrolyzed)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_113571", "map_id": "CHEBI:15996", "name": "GTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10582399", "map_id": "none", "name": "Capping complex (intermediate)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_111349", "map_id": "CHEBI:17552", "name": "GDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10582418", "map_id": "none", "name": "Formation of cap binding complex (CBC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10578795", "map_id": "Q54KR9", "name": "ncbp2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10578800", "map_id": "Q55D17", "name": "ncbp1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10578802", "map_id": "none", "name": "Cap Binding Complex (CBC)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10582420", "map_id": "none", "name": "Recognition and binding of the mRNA cap by the cap-binding complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10582407", "map_id": "none", "name": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10582404", "map_id": "none", "name": "Capping complex (GpppN..)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10582390", "map_id": "none", "name": "Capping complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_72084", "map_id": "none", "name": "nascent pre-mRNA transcript", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10582388", "map_id": "none", "name": "Capping complex (initial)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10582395", "map_id": "none", "name": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10582411", "map_id": "none", "name": "Dissociation of transcript with 5'-GMP from GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10624148", "map_id": "none", "name": "KDM6B binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10602196", "map_id": "O77033", "name": "trfA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_111793", "map_id": "CHEBI:29033", "name": "Fe2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10602198", "map_id": "none", "name": "KDM6B:Fe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O77033", "map_id": "O77033", "name": "trfA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10602201", "map_id": "none", "name": "KDM6B demethylates H3K27me3 on p16INK4A promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10602189", "map_id": "none", "name": "CDKN2A Gene:H3K27Me3-Nucleosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10602191", "map_id": "none", "name": "CDKN2A Gene:Nucleosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10594065", "map_id": "none", "name": "Activated NOD2 oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10584517", "map_id": "none", "name": "MDP:NOD2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86KC0", "map_id": "Q86KC0", "name": "NOD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274183", "map_id": "DDB_G0274183", "name": "NOD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_708341", "map_id": "CHEBI:59414", "name": "MDP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10584519", "map_id": "none", "name": "MDP:NOD2 oligomer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10594037", "map_id": "none", "name": "Activated NOD1 oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10584509", "map_id": "none", "name": "NOD1:iE-DAP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_622271", "map_id": "CHEBI:59271", "name": "iE-DAP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10584513", "map_id": "none", "name": "NOD1:iE-DAP oligomer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10627336", "map_id": "none", "name": "AAMP binds NOD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10627244", "map_id": "Q55E90", "name": "AAMP", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0269344", "map_id": "DDB_G0269344", "name": "AAMP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10584515", "map_id": "Q86KC0", "name": "NOD2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10627334", "map_id": "none", "name": "AAMP:NOD2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55E90", "map_id": "Q55E90", "name": "AAMP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10584557", "map_id": "none", "name": "Activated NOD oligomer recruites RIP2 (RICK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10584553", "map_id": "none", "name": "Homologues of RIPK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54IP4", "map_id": "Q54IP4", "name": "shkB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288617", "map_id": "DDB_G0288617", "name": "shkB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54Y55", "map_id": "Q54Y55", "name": "shkC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0278409", "map_id": "DDB_G0278409", "name": "shkC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86HG9", "map_id": "Q86HG9", "name": "RIPK2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271682", "map_id": "DDB_G0271682", "name": "RIPK2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RB7", "map_id": "Q54RB7", "name": "shkA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283267", "map_id": "DDB_G0283267", "name": "shkA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54U31", "map_id": "Q54U31", "name": "shkD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281343", "map_id": "DDB_G0281343", "name": "shkD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54G43", "map_id": "Q54G43", "name": "shkE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290451", "map_id": "DDB_G0290451", "name": "shkE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10584521", "map_id": "none", "name": "PAMP:NOD oligomer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10584555", "map_id": "none", "name": "PAMP:NOD oligomer:RIP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10584511", "map_id": "none", "name": "iE-DAP elicits a NOD1 response", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10584507", "map_id": "Q86KC0", "name": "NOD1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10584559", "map_id": "none", "name": "MDP elicits a NOD2 response", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10615701", "map_id": "none", "name": "Exocytosis of azurophil granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1470028", "compartment_display": "azurophil granule lumen" }, { "id": "species_10615569", "map_id": "none", "name": "Azurophil granule lumen proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1470028", "compartment_display": "azurophil granule lumen", "complex": "true" }, { "id": "Q54VE2", "map_id": "Q54VE2", "name": "FAF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280423", "map_id": "DDB_G0280423", "name": "FAF2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54P50", "map_id": "Q54P50", "name": "PLAC8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287731", "map_id": "DDB_G0287731", "name": "PLAC8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B0G108", "map_id": "B0G108", "name": "PLAC8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q554H6", "map_id": "Q554H6", "name": "PLAC8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JY8", "map_id": "Q54JY8", "name": "PLAC8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86HR5", "map_id": "Q86HR5", "name": "CREG1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274461", "map_id": "DDB_G0274461", "name": "CREG1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HT4", "map_id": "Q54HT4", "name": "DPP7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289231", "map_id": "DDB_G0289231", "name": "DPP7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54H23", "map_id": "Q54H23", "name": "PRCP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289749", "map_id": "DDB_G0289749", "name": "PRCP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55F06", "map_id": "Q55F06", "name": "UNC13D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279583", "map_id": "DDB_G0279583", "name": "UNC13D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WK5", "map_id": "Q54WK5", "name": "UNC13D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C7FZY2", "map_id": "C7FZY2", "name": "RNASET2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0295845", "map_id": "DDB_G0295845", "name": "RNASET2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54654", "map_id": "P54654", "name": "cap", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288769", "map_id": "DDB_G0288769", "name": "cap", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C7G009", "map_id": "C7G009", "name": "TXNDC5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0295811", "map_id": "DDB_G0295811", "name": "TXNDC5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P32256", "map_id": "P32256", "name": "tubB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269196", "map_id": "DDB_G0269196", "name": "tubB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6TMK4", "map_id": "Q6TMK4", "name": "poxA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54HL4", "map_id": "Q54HL4", "name": "gghB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289365", "map_id": "DDB_G0289365", "name": "gghB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1ZXG4", "map_id": "Q1ZXG4", "name": "prlA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282361", "map_id": "DDB_G0282361", "name": "prlA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54GE1", "map_id": "Q54GE1", "name": "glb1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10615699", "map_id": "none", "name": "Azurophil granule lumen proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10616165", "map_id": "none", "name": "Exocytosis of ficolin-rich granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6800424", "compartment_display": "ficolin-1-rich granule membrane" }, { "id": "species_10616149", "map_id": "none", "name": "Ficolin-rich granule membrane proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6800424", "compartment_display": "ficolin-1-rich granule membrane", "complex": "true" }, { "id": "Q54QG5", "map_id": "Q54QG5", "name": "UBR4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283893", "map_id": "DDB_G0283893", "name": "UBR4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q557H3", "map_id": "Q557H3", "name": "C16orf62", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273473", "map_id": "DDB_G0273473", "name": "C16orf62", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54R04", "map_id": "Q54R04", "name": "arl8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283525", "map_id": "DDB_G0283525", "name": "arl8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86JN1", "map_id": "Q86JN1", "name": "STBD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0272062", "map_id": "DDB_G0272062", "name": "STBD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q869V1", "map_id": "Q869V1", "name": "nramp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54U63", "map_id": "Q54U63", "name": "lvsC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0280971", "map_id": "DDB_G0280971", "name": "lvsC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55AV3", "map_id": "Q55AV3", "name": "lvsD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271502", "map_id": "DDB_G0271502", "name": "lvsD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55DM1", "map_id": "Q55DM1", "name": "lvsA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269150", "map_id": "DDB_G0269150", "name": "lvsA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86JF2", "map_id": "Q86JF2", "name": "lvsB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271504", "map_id": "DDB_G0271504", "name": "lvsB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54RQ8", "map_id": "Q54RQ8", "name": "lvsE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282925", "map_id": "DDB_G0282925", "name": "lvsE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54U95", "map_id": "Q54U95", "name": "ATP6AP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0281325", "map_id": "DDB_G0281325", "name": "ATP6AP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10616163", "map_id": "none", "name": "Ficolin-rich granule membrane proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10614836", "map_id": "none", "name": "Exocytosis of tertiary granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6799713", "compartment_display": "tertiary granule membrane" }, { "id": "species_10614736", "map_id": "none", "name": "Tertiary granule membrane proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6799713", "compartment_display": "tertiary granule membrane", "complex": "true" }, { "id": "Q54F95", "map_id": "Q54F95", "name": "STOM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0290995", "map_id": "DDB_G0290995", "name": "STOM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54K65", "map_id": "Q54K65", "name": "STOM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10614834", "map_id": "none", "name": "Tertiary granule membrane proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10616436", "map_id": "none", "name": "Exocytosis of ficolin-rich granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10616414", "map_id": "none", "name": "Ficolin-rich granule lumen proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6800405", "compartment_display": "ficolin-1-rich granule lumen", "complex": "true" }, { "id": "Q55GA9", "map_id": "Q55GA9", "name": "APEH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PG1", "map_id": "Q54PG1", "name": "dlcA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284589", "map_id": "DDB_G0284589", "name": "dlcA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q5R1U3", "map_id": "Q5R1U3", "name": "cpiC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277001", "map_id": "DDB_G0277001", "name": "cpiC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54B14", "map_id": "Q54B14", "name": "qpct", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0293986", "map_id": "DDB_G0293986", "name": "qpct", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55FR5", "map_id": "Q55FR5", "name": "ypel", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267990", "map_id": "DDB_G0267990", "name": "ypel", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54K94", "map_id": "Q54K94", "name": "AGL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q556U5", "map_id": "Q556U5", "name": "PDAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0273095", "map_id": "DDB_G0273095", "name": "PDAP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C7G028", "map_id": "C7G028", "name": "CAB39", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284307", "map_id": "DDB_G0284307", "name": "CAB39", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MUF9", "map_id": "Q8MUF9", "name": "cplA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269200", "map_id": "DDB_G0269200", "name": "cplA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54S93", "map_id": "Q54S93", "name": "gmfA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282595", "map_id": "DDB_G0282595", "name": "gmfA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O96923", "map_id": "O96923", "name": "gnrA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291125", "map_id": "DDB_G0291125", "name": "gnrA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P10733", "map_id": "P10733", "name": "sevA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289327", "map_id": "DDB_G0289327", "name": "sevA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q551I6", "map_id": "Q551I6", "name": "GSN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276571", "map_id": "DDB_G0276571", "name": "GSN", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QS3", "map_id": "Q54QS3", "name": "ddx3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283661", "map_id": "DDB_G0283661", "name": "ddx3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54QK4", "map_id": "Q54QK4", "name": "commd3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283795", "map_id": "DDB_G0283795", "name": "commd3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54IS1", "map_id": "Q54IS1", "name": "CTSB(80-333)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288563", "map_id": "DDB_G0288563", "name": "CTSB(80-333)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34118", "map_id": "P34118", "name": "mvpA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269156", "map_id": "DDB_G0269156", "name": "mvpA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10616434", "map_id": "none", "name": "Ficolin-rich granule lumen proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10615963", "map_id": "none", "name": "Exocytosis of specific granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6799351", "compartment_display": "specific granule membrane" }, { "id": "species_10615937", "map_id": "none", "name": "Specific granule membrane proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6799351", "compartment_display": "specific granule membrane", "complex": "true" }, { "id": "Q02465", "map_id": "Q02465", "name": "spiA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0289075", "map_id": "DDB_G0289075", "name": "spiA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P34138", "map_id": "P34138", "name": "ptpB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0277865", "map_id": "DDB_G0277865", "name": "ptpB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54637", "map_id": "P54637", "name": "ptpC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282145", "map_id": "DDB_G0282145", "name": "ptpC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q869T7", "map_id": "Q869T7", "name": "pakF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274409", "map_id": "DDB_G0274409", "name": "pakF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54S39", "map_id": "Q54S39", "name": "PGRMC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282683", "map_id": "DDB_G0282683", "name": "PGRMC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q551J1", "map_id": "Q551J1", "name": "TMEM30A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276567", "map_id": "DDB_G0276567", "name": "TMEM30A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55D94", "map_id": "Q55D94", "name": "DEGS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10615961", "map_id": "none", "name": "Specific granule membrane proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10614058", "map_id": "none", "name": "Exocytosis of azurophil granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6798757", "compartment_display": "azurophil granule membrane" }, { "id": "species_10613932", "map_id": "none", "name": "Azurophil granule membrane proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6798757", "compartment_display": "azurophil granule membrane", "complex": "true" }, { "id": "Q54DE8", "map_id": "Q54DE8", "name": "psenB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292310", "map_id": "DDB_G0292310", "name": "psenB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54ET2", "map_id": "Q54ET2", "name": "psenA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291352", "map_id": "DDB_G0291352", "name": "psenA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q552S3", "map_id": "Q552S3", "name": "MANBA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LZ3", "map_id": "Q54LZ3", "name": "DNAJC13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286293", "map_id": "DDB_G0286293", "name": "DNAJC13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54E62", "map_id": "Q54E62", "name": "ddost", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291780", "map_id": "DDB_G0291780", "name": "ddost", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54P71", "map_id": "Q54P71", "name": "ACPP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0284755", "map_id": "DDB_G0284755", "name": "ACPP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54P72", "map_id": "Q54P72", "name": "ACPP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54PR9", "map_id": "Q54PR9", "name": "cf60", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54N33", "map_id": "Q54N33", "name": "ost3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JT7", "map_id": "Q54JT7", "name": "ncstn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287801", "map_id": "DDB_G0287801", "name": "ncstn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10614056", "map_id": "none", "name": "Azurophil granule membrane proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10615338", "map_id": "none", "name": "Exocytosis of specific granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6799371", "compartment_display": "specific granule lumen" }, { "id": "species_10615290", "map_id": "none", "name": "Specific granule lumen proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6799371", "compartment_display": "specific granule lumen", "complex": "true" }, { "id": "Q55D97", "map_id": "Q55D97", "name": "armc8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270626", "map_id": "DDB_G0270626", "name": "armc8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54JM9", "map_id": "Q54JM9", "name": "nit2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0287939", "map_id": "DDB_G0287939", "name": "nit2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10615336", "map_id": "none", "name": "Specific granule lumen proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10615210", "map_id": "none", "name": "Exocytosis of secretory granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen" }, { "id": "species_10615050", "map_id": "none", "name": "Secretory granule lumen proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen", "complex": "true" }, { "id": "species_10615208", "map_id": "none", "name": "Secretory granule lumen proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10614349", "map_id": "none", "name": "Exocytosis of secretory granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10614243", "map_id": "none", "name": "Secretory granule membrane proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_216813", "compartment_display": "secretory granule membrane", "complex": "true" }, { "id": "Q55FU9", "map_id": "Q55FU9", "name": "rab24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268402", "map_id": "DDB_G0268402", "name": "rab24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54DA7", "map_id": "Q54DA7", "name": "rab4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292406", "map_id": "DDB_G0292406", "name": "rab4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10614347", "map_id": "none", "name": "Secretory granule membrane proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10614542", "map_id": "none", "name": "Exocytosis of tertiary granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6800173", "compartment_display": "tertiary granule lumen" }, { "id": "species_10614462", "map_id": "none", "name": "Tertiary granule lumen proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6800173", "compartment_display": "tertiary granule lumen", "complex": "true" }, { "id": "species_10614540", "map_id": "none", "name": "Tertiary granule lumen proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10612848", "map_id": "none", "name": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_21994", "compartment_display": "phagocytic vesicle" }, { "id": "species_1222719", "map_id": "CHEBI:16240", "name": "H2O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "species_6788973", "map_id": "CHEBI:17996", "name": "Cl-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "species_1222475", "map_id": "CHEBI:15377", "name": "H2O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "species_6789150", "map_id": "CHEBI:24757", "name": "HOCl", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "species_10612845", "map_id": "none", "name": "MPO:ferriheme:bacterial cell surface", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "true" }, { "id": "CHEBI:55376", "map_id": "CHEBI:55376", "name": "CHEBI:55376", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10612851", "map_id": "none", "name": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen" }, { "id": "species_10612843", "map_id": "none", "name": "MPO:ferriheme", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "true" }, { "id": "reaction_10612853", "map_id": "none", "name": "Myeloperoxidase (MPO) binds to the bacterial cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_21994", "compartment_display": "phagocytic vesicle" }, { "id": "species_983438", "map_id": "none", "name": "Cell surface", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10622909", "map_id": "none", "name": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen" }, { "id": "species_6789221", "map_id": "CHEBI:16301", "name": "nitrite", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "species_8933637", "map_id": "CHEBI:33101", "name": "NO2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "reaction_10619501", "map_id": "none", "name": "Lactoperoxidase (LPO) produces OSCN-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_8855492", "map_id": "CHEBI:18022", "name": "SCN(-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_8855489", "map_id": "CHEBI:133907", "name": "OSCN-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10619498", "map_id": "none", "name": "LPO:ferriheme", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10597227", "map_id": "none", "name": "Intraphagosomal pH is lowered to 5 by V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1222693", "compartment_display": "phagocytic vesicle membrane" }, { "id": "species_10597224", "map_id": "none", "name": "V-ATPase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222693", "compartment_display": "phagocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10593221", "map_id": "none", "name": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10593206", "map_id": "Q55CQ7", "name": "tnpo", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0269948", "map_id": "DDB_G0269948", "name": "tnpo", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_450597", "map_id": "none", "name": "mRNA Transcript Targeted by Tristetraproline", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10593217", "map_id": "Q54MG5", "name": "ZFP36", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10593219", "map_id": "none", "name": "TTP:mRNA Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55CQ7", "map_id": "Q55CQ7", "name": "tnpo", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10593230", "map_id": "none", "name": "ZFP36 (TTP) recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10593228", "map_id": "none", "name": "TTP:mRNA Degradation Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10602772", "map_id": "none", "name": "Constitutive phosphorylation by GSK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602761", "map_id": "Q54UC1", "name": "HSF1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10602764", "map_id": "Q54UC1", "name": "phospho-p-S303-HSF1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10602769", "map_id": "P51136", "name": "gskA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0272110", "map_id": "DDB_G0272110", "name": "gskA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10602840", "map_id": "none", "name": "DBC1 is phosphorylated by ATM/ART", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10602832", "map_id": "Q86A78", "name": "DG1124", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10602826", "map_id": "Q86A78", "name": "phospho-DG1124", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10602837", "map_id": "Q54ER4", "name": "atr1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "DDB_G0291380", "map_id": "DDB_G0291380", "name": "atr1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10602830", "map_id": "none", "name": "DBC1 binds SIRT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10591478", "map_id": "Q54GV7", "name": "sir2D", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10602828", "map_id": "none", "name": "p-T454-DBC1:SIRT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10602865", "map_id": "none", "name": "Trimerization of cytosolic HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602814", "map_id": "none", "name": "HSF1 trimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10605045", "map_id": "none", "name": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5324631", "map_id": "none", "name": "Ub-protein aggregates", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10605040", "map_id": "none", "name": "HSF1:HSP90:HDAC6:VCP:PTGES3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10605042", "map_id": "none", "name": "HDAC6:VCP:protein aggregates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10602820", "map_id": "none", "name": "HSF1 trimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10602857", "map_id": "none", "name": "Dissociation of cytosolic HSF1:HSP90 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10602855", "map_id": "none", "name": "HSF1:HSP90:PTGES3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10604376", "map_id": "none", "name": "Dissociation of HSF1:HSP90 complex in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10604374", "map_id": "none", "name": "HSF1:HSP90:PTGES3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10604366", "map_id": "Q55FM3", "name": "PTGES3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10604347", "map_id": "Q54UC1", "name": "HSF1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10604372", "map_id": "none", "name": "HSP90:HSP90", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10604349", "map_id": "none", "name": "Trimerization of HSF1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10582483", "map_id": "none", "name": "Recruitment of CstF to the CPSF Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10582477", "map_id": "none", "name": "CPSF:capped intronless pre-mRNA:CBC complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10579555", "map_id": "none", "name": "CstF", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10582481", "map_id": "none", "name": "CstF:CPSF:capped intronless pre-mRNA:CBC complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10582479", "map_id": "none", "name": "Recognition of AAUAAA sequence by CPSF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10579534", "map_id": "none", "name": "CPSF", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10582475", "map_id": "none", "name": "capped intronless pre-mRNA:CBC complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10601473", "map_id": "none", "name": "GUCA binds Ca2+ to form GUCA:Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10581368", "map_id": "Q75K28", "name": "ncsA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "false" }, { "id": "DDB_G0275931", "map_id": "DDB_G0275931", "name": "ncsA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10581380", "map_id": "none", "name": "GUCA:Ca2+", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "true" }, { "id": "Q75K28", "map_id": "Q75K28", "name": "ncsA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10601385", "map_id": "none", "name": "NMT1/2 transfer MYS to GNAT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10601375", "map_id": "none", "name": "Homologues of GNAT1 (Met removed)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_2534019", "map_id": "CHEBI:15532", "name": "MYS-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10581129", "map_id": "none", "name": "Homologues of N-(C14:0)-GNAT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "true" }, { "id": "species_10601380", "map_id": "Q553B6", "name": "nmt", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0275863", "map_id": "DDB_G0275863", "name": "nmt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10601432", "map_id": "none", "name": "METAP1/2 demethylates GNAT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10601413", "map_id": "none", "name": "Homologues of GNAT1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10601429", "map_id": "none", "name": "METAP1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55C21", "map_id": "Q55C21", "name": "metap2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0270264", "map_id": "DDB_G0270264", "name": "metap2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54WU3", "map_id": "Q54WU3", "name": "metap1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279433", "map_id": "DDB_G0279433", "name": "metap1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10581390", "map_id": "none", "name": "GUCYs converts GTP to cGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane" }, { "id": "species_10581362", "map_id": "none", "name": "GUCYs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "true" }, { "id": "Q03101", "map_id": "Q03101", "name": "acgA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274569", "map_id": "DDB_G0274569", "name": "acgA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q553Y7", "map_id": "Q553Y7", "name": "gca", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0275009", "map_id": "DDB_G0275009", "name": "gca", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10581382", "map_id": "Q75K28", "name": "ncsA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10581384", "map_id": "Q75K28", "name": "ncsA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10581386", "map_id": "none", "name": "GCAP1:Ca2+", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10581388", "map_id": "none", "name": "GCAP2:Ca2+", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10591906", "map_id": "none", "name": "Lsm1-7 Complex binds deadenylated mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10591863", "map_id": "none", "name": "Lsm1-7 Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55F60", "map_id": "Q55F60", "name": "PATL1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0268244", "map_id": "DDB_G0268244", "name": "PATL1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54W83", "map_id": "Q54W83", "name": "lsm1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0279837", "map_id": "DDB_G0279837", "name": "lsm1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10591865", "map_id": "none", "name": "Deadenylated mRNA:Lsm1-7 Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10591896", "map_id": "none", "name": "DCP1-DCP2 complex decaps mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10591867", "map_id": "none", "name": "Decapped mRNA:LSM1-7 Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_430004", "map_id": "CHEBI:20794", "name": "7-MeGDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10591893", "map_id": "none", "name": "DCP1-DCP2 Decapping Complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54E49", "map_id": "Q54E49", "name": "ddx6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0291804", "map_id": "DDB_G0291804", "name": "ddx6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54J96", "map_id": "Q54J96", "name": "EDC4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288241", "map_id": "DDB_G0288241", "name": "EDC4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10589052", "map_id": "none", "name": "NPC1L1 inactivation by ezetimibe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10589048", "map_id": "none", "name": "Homologues of NPC1L1-1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q551C5", "map_id": "Q551C5", "name": "NPC1L1-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276657", "map_id": "DDB_G0276657", "name": "NPC1L1-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_265479", "map_id": "CHEBI:49040", "name": "EZE", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10589050", "map_id": "none", "name": "NPC1L1:ezetimibe complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10619411", "map_id": "none", "name": "TBC1D15 accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10619394", "map_id": "none", "name": "RAB7:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10619396", "map_id": "none", "name": "RAB7:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10619409", "map_id": "none", "name": "Homologues of TBC1D15", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54IE1", "map_id": "Q54IE1", "name": "TBC1D15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0288811", "map_id": "DDB_G0288811", "name": "TBC1D15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54UD8", "map_id": "Q54UD8", "name": "TBC1D15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10619424", "map_id": "none", "name": "TBC1D25 (OATL1) binds ATG8 homologues", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5683628", "compartment_display": "autophagosome membrane" }, { "id": "species_10619420", "map_id": "none", "name": "Homologues of TBC1D25", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5683636", "compartment_display": "autophagosome", "complex": "true" }, { "id": "species_10619414", "map_id": "none", "name": "ATG8 homologues", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5683628", "compartment_display": "autophagosome membrane", "complex": "true" }, { "id": "species_10619422", "map_id": "none", "name": "TBC1D25:ATG8 homoogues", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5683628", "compartment_display": "autophagosome membrane", "complex": "true" }, { "id": "reaction_10619313", "map_id": "none", "name": "TBC1D10A binds JFC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_19363", "compartment_display": "microvillus" }, { "id": "species_10619309", "map_id": "none", "name": "Homologues of TBC1D10A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_19363", "compartment_display": "microvillus", "complex": "true" }, { "id": "species_10619303", "map_id": "Q54RR0", "name": "JFC1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_172780", "compartment_display": "microvillus membrane", "complex": "false" }, { "id": "species_10619311", "map_id": "none", "name": "TBC1D10A:JFC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_172780", "compartment_display": "microvillus membrane", "complex": "true" }, { "id": "reaction_10619441", "map_id": "none", "name": "TBC1D16 accelerates GTP hydrolysis by RAB4A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_437051", "compartment_display": "cytoplasmic vesicle membrane" }, { "id": "species_10619430", "map_id": "none", "name": "GGC-RAB4A:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_437051", "compartment_display": "cytoplasmic vesicle membrane", "complex": "true" }, { "id": "species_10619432", "map_id": "none", "name": "GGC-RAB4A:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_437051", "compartment_display": "cytoplasmic vesicle membrane", "complex": "true" }, { "id": "species_10619439", "map_id": "none", "name": "Homologues of TBC1D16", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10619366", "map_id": "none", "name": "TBC1D11 binds RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10618515", "map_id": "none", "name": "RAB6:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10619362", "map_id": "Q54FT8", "name": "RABGAP1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0290597", "map_id": "DDB_G0290597", "name": "RABGAP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10619364", "map_id": "none", "name": "RABGAP1:RAB6:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q54FT8", "map_id": "Q54FT8", "name": "RABGAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10619478", "map_id": "none", "name": "TBC1D14 binds RAB11 and ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane" }, { "id": "species_10619469", "map_id": "Q86CS2", "name": "atg1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_261116", "compartment_display": "recycling endosome", "complex": "false" }, { "id": "species_10619467", "map_id": "none", "name": "RAB11", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane", "complex": "true" }, { "id": "species_10619474", "map_id": "O96904", "name": "phgA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_261116", "compartment_display": "recycling endosome", "complex": "false" }, { "id": "DDB_G0269130", "map_id": "DDB_G0269130", "name": "phgA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10619476", "map_id": "none", "name": "TBC1D14:RAB11:ULK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane", "complex": "true" }, { "id": "O96904", "map_id": "O96904", "name": "phgA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10619300", "map_id": "none", "name": "TBC RabGAPs accelerate GTP hydrolysis by RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane" }, { "id": "species_10619265", "map_id": "none", "name": "RAB35:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "species_10619267", "map_id": "none", "name": "RAB35:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "species_10619298", "map_id": "none", "name": "RAB35 specific TBC RabGAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54CG7", "map_id": "Q54CG7", "name": "TBC1D24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0292932", "map_id": "DDB_G0292932", "name": "TBC1D24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55F14", "map_id": "Q55F14", "name": "TBC1D13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269052", "map_id": "DDB_G0269052", "name": "TBC1D13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10619352", "map_id": "none", "name": "TBC1D10A (EPI64) binds ARF6:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane" }, { "id": "species_10619348", "map_id": "none", "name": "ARF6:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane", "complex": "true" }, { "id": "Q554Y8", "map_id": "Q554Y8", "name": "arrB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0274445", "map_id": "DDB_G0274445", "name": "arrB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10619350", "map_id": "none", "name": "TBC1D10A:ARF6:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane", "complex": "true" }, { "id": "reaction_10619340", "map_id": "none", "name": "TBC1D2A accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10619323", "map_id": "none", "name": "RAB7A:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10619325", "map_id": "none", "name": "RAB7A:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10619338", "map_id": "none", "name": "Homologues of TBC1D2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q553Q2", "map_id": "Q553Q2", "name": "TBC1D2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0295717", "map_id": "DDB_G0295717", "name": "TBC1D2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C7G032", "map_id": "C7G032", "name": "TBC1D2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55E78", "map_id": "Q55E78", "name": "TBC1D2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q553U1", "map_id": "Q553U1", "name": "TBC1D2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q75JG4", "map_id": "Q75JG4", "name": "cnrF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0276119", "map_id": "DDB_G0276119", "name": "cnrF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10619453", "map_id": "none", "name": "TBC1D25 accelerates GTP hydrolysis by RAB33B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5683628", "compartment_display": "autophagosome membrane" }, { "id": "species_10619448", "map_id": "none", "name": "RAB33:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10619450", "map_id": "none", "name": "RAB33:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10594836", "map_id": "none", "name": "Cargo Sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10594815", "map_id": "none", "name": "ESCRT-I/Cargo Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "Q55DV8", "map_id": "Q55DV8", "name": "vps37", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0269510", "map_id": "DDB_G0269510", "name": "vps37", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54NF1", "map_id": "Q54NF1", "name": "vps28", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0285295", "map_id": "DDB_G0285295", "name": "vps28", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54LJ3", "map_id": "Q54LJ3", "name": "tsg101", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0286797", "map_id": "DDB_G0286797", "name": "tsg101", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10594832", "map_id": "none", "name": "ESCRT-II", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54RC4", "map_id": "Q54RC4", "name": "snf8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0283203", "map_id": "DDB_G0283203", "name": "snf8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q55GD9", "map_id": "Q55GD9", "name": "vps25", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0267708", "map_id": "DDB_G0267708", "name": "vps25", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q54T18", "map_id": "Q54T18", "name": "vps36", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0282045", "map_id": "DDB_G0282045", "name": "vps36", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10594813", "map_id": "none", "name": "ESCRT-I", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "species_10594834", "map_id": "none", "name": "ESCRT-II/Cargo Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10594788", "map_id": "none", "name": "ESCRT Disassembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10594631", "map_id": "none", "name": "ESCRT-III/Cargo Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "species_10594475", "map_id": "Q86H98", "name": "chmp4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10594489", "map_id": "Q54JK4", "name": "chmp5", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10594470", "map_id": "Q54P63", "name": "chmp3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10594484", "map_id": "Q54KZ4", "name": "chmp6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10594769", "map_id": "none", "name": "Ubiquinated and PIP3 Endosmal Membrane Bound Cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24337", "compartment_display": "endocytic vesicle membrane", "complex": "true" }, { "id": "species_10594465", "map_id": "Q54GK9", "name": "chmp2a1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10594785", "map_id": "none", "name": "Vps/Vta1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q55B11", "map_id": "Q55B11", "name": "vta1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DDB_G0271488", "map_id": "DDB_G0271488", "name": "vta1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10594838", "map_id": "none", "name": "MVB Vesicle Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10611220", "map_id": "none", "name": "CANDI binds CUL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10585421", "map_id": "O60999", "name": "culA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10611218", "map_id": "none", "name": "CANDI:CUL1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10611211", "map_id": "none", "name": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10611084", "map_id": "Q54X73", "name": "aco1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "DDB_G0279159", "map_id": "DDB_G0279159", "name": "aco1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10611202", "map_id": "Q54X73", "name": "aco1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10611208", "map_id": "none", "name": "SKP1:FBXL5:CUL1:NEDD8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10611082", "map_id": "none", "name": "ACO1 binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5690881", "map_id": "none", "name": "4Fe-4S", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10611078", "map_id": "Q54X73", "name": "aco1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10611080", "map_id": "none", "name": "ACO1:4Fe-4S", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q54X73", "map_id": "Q54X73", "name": "aco1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10594848", "map_id": "none", "name": "MCOLN1 transports Fe2+ from endosome lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_917810", "map_id": "CHEBI:29033", "name": "Fe2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171907", "compartment_display": "endosome lumen", "complex": "false" }, { "id": "species_10594845", "map_id": "Q54EY0", "name": "MCOLN1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "false" }, { "id": "reaction_10594840", "map_id": "none", "name": "Acidification of Tf:TfR1 containing endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "reaction_10611087", "map_id": "none", "name": "ACO1:4Fe-4S isomerises CIT to ISCIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"reaction_10607358", "reaction_10626928", "reaction_10606568", "reaction_10607279", "reaction_10626891", "reaction_10627079", "reaction_10626685", "reaction_10607267", "reaction_10626822", "reaction_10626925", "reaction_10626990", "reaction_10626903", "reaction_10606970", "reaction_10627061", "reaction_10626994", "reaction_10607271", "reaction_10607253", "reaction_10607298", "reaction_10607066", "reaction_10607347", "reaction_10607319", "reaction_10607245", "reaction_10626939", "reaction_10606532", "reaction_10606564", "reaction_10627146", "reaction_10627077", "reaction_10626905", "reaction_10607367", "reaction_10627083", "reaction_10606566", "reaction_10626932", "reaction_10627075", "reaction_10626920" ] }, "R-DDI-3108232": { "id": "pathway_10629084", "reactome": "R-DDI-3108232", "name": "SUMO E3 ligases SUMOylate target proteins", "reactions": [ "reaction_10601901", "reaction_10604098", "reaction_10601939", "reaction_10604151", "reaction_10604146", "reaction_10603511", "reaction_10603528", "reaction_10603971", "reaction_10603446", "reaction_10603490", "reaction_10604001", "reaction_10604058", "reaction_10603889", "reaction_10601914", "reaction_10603389", "reaction_10604075", "reaction_10603847", "reaction_10603903", "reaction_10601851", "reaction_10603956", "reaction_10602028", "reaction_10603757", "reaction_10603718", "reaction_10601830", "reaction_10604171", "reaction_10603563", "reaction_10602897", "reaction_10603823", "reaction_10603374", "reaction_10604016", "reaction_10603395", "reaction_10603474", "reaction_10603944", "reaction_10604118", "reaction_10601815", "reaction_10603949", "reaction_10603991", "reaction_10603872" ] } }, "reaction_dictionary": { "reaction_10584068": { "compartment": "compartment_7660", "id": "reaction_10584068", "reactome": "R-DDI-163733", "name": "Transcriptional activation of FAS monomer gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10581670" ], "modifiers": [], "additional_components": [ "Q869X2", "DDB_G0275077", "Q55E72", "DDB_G0269364", "Q869W9", "DDB_G0275069" ] }, "reaction_10584072": { "compartment": "compartment_7660", "id": "reaction_10584072", "reactome": "R-DDI-163743", "name": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10584070" ], "modifiers": [], "additional_components": [ "DDB_G0288387" ] }, "reaction_10584074": { "compartment": "compartment_7660", "id": "reaction_10584074", "reactome": "R-DDI-163748", "name": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10581684" ], "modifiers": [], "additional_components": [ "DDB_G0291332" ] }, "reaction_10601278": { "compartment": "compartment_984", "id": "reaction_10601278", "reactome": "R-DDI-2514772", "name": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600215" ], "products": [ "species_10601195" ], "modifiers": [ [ "species_10601275", "catalyst" ] ], "additional_components": [ "Q54IA3", "DDB_G0295485", "B0G154", "DDB_G0295485", "Q54IA3", "DDB_G0295485", "B0G154", "DDB_G0295485", "Q54TR1", "DDB_G0281605", "Q54UH2", "DDB_G0282991", "Q54UH3", "DDB_G0282991", "Q86KD4", "DDB_G0282991", "P04989", "DDB_G0279799", "Q23894", "DDB_G0283867", "Q54RQ2", "DDB_G0282991" ] }, "reaction_10603294": { "compartment": "compartment_984", "id": "reaction_10603294", "reactome": "R-DDI-3814820", "name": "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598295" ], "products": [ "species_10603257", "species_10603255" ], "modifiers": [ [ "species_10603291", "catalyst" ] ], "additional_components": [ "DDB_G0270488", "DDB_G0270488", "DDB_G0270488", "Q54TR1", "DDB_G0281605", "Q54UH2", "DDB_G0282991", "Q54UH3", "DDB_G0282991", "Q86KD4", "DDB_G0282991", "P04989", "DDB_G0279799", "Q23894", "DDB_G0283867", "Q54RQ2", "DDB_G0282991" ] }, "reaction_10594336": { "compartment": "compartment_13231", "id": "reaction_10594336", "reactome": "R-DDI-913529", "name": "Translocation of p-STAT1:p-STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594322" ], "products": [ "species_10594334" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167" ] }, "reaction_10597154": { "compartment": "compartment_70101", "id": "reaction_10597154", "reactome": "R-DDI-1169397", "name": "Activation of ISG15 by UBA7 E1 ligase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10595036", "species_113592", "species_10595029" ], "products": [ "species_111294", "species_10597151", "species_76577" ], "modifiers": [ [ "species_10595036", "catalyst" ] ], "additional_components": [ "DDB_G0270272", "DDB_G0292984", "Q54CI1", "DDB_G0292984", "Q55C16", "DDB_G0270272", "DDB_G0270272" ] }, "reaction_10597170": { "compartment": "compartment_70101", "id": "reaction_10597170", "reactome": "R-DDI-1169404", "name": "Transfer of ISG15 from E1 to E2 (UBCH8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597151", "species_10595031" ], "products": [ "species_10595036", "species_10597143" ], "modifiers": [ [ "species_10595031", "catalyst" ] ], "additional_components": [ "Q54CI1", "DDB_G0292984", "Q55C16", "DDB_G0270272", "DDB_G0281833", "DDB_G0270272", "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "DDB_G0281833" ] }, "reaction_10597158": { "compartment": "compartment_70101", "id": "reaction_10597158", "reactome": "R-DDI-1169399", "name": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596135", "species_10595029" ], "products": [ "species_10597156" ], "modifiers": [], "additional_components": [ "C7G034", "DDB_G0285063", "Q54QF1", "DDB_G0283983", "DDB_G0292984", "Q54CI1", "DDB_G0292984", "C7G034", "DDB_G0285063", "Q54QF1", "DDB_G0283983" ] }, "reaction_10599224": { "compartment": "compartment_70101", "id": "reaction_10599224", "reactome": "R-DDI-1678842", "name": "Competitive inhibition of translation initiation by ISGylated 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599208", "species_10599220" ], "products": [ "species_10599222", "species_10599218" ], "modifiers": [], "additional_components": [ "B0G0Z1", "DDB_G0284841", "Q54E38", "DDB_G0291820", "Q55BQ5", "DDB_G0284841", "Q54P37", "DDB_G0284841", "Q54T63", "DDB_G0284841", "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043", "Q55FE0", "DDB_G0268574", "Q54E38", "DDB_G0291820", "Q553R3", "DDB_G0275395", "Q55D61", "DDB_G0269192", "P90529", "DDB_G0269146", "B0G0Z1", "DDB_G0284841", "Q54E38", "DDB_G0291820", "Q55BQ5", "DDB_G0284841", "Q54P37", "DDB_G0284841", "Q54T63", "DDB_G0284841", "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043", "Q55FE0", "DDB_G0268574", "Q54E38", "DDB_G0291820", "Q553R3", "DDB_G0275395", "Q55D61", "DDB_G0269192", "P90529", "DDB_G0269146" ] }, "reaction_10597192": { "compartment": "compartment_70101", "id": "reaction_10597192", "reactome": "R-DDI-1169406", "name": "ISGylation of host proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597149", "species_113592", "species_10597188" ], "products": [ "species_111294", "species_10597147", "species_10597190", "species_10595031", "species_76577" ], "modifiers": [ [ "species_10597149", "catalyst" ] ], "additional_components": [ "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q54TE1", "DDB_G0281833", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043", "Q54CI1", "DDB_G0292984", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q54TE1", "DDB_G0281833", "DDB_G0281833", "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043" ] }, "reaction_10599179": { "compartment": "compartment_70101", "id": "reaction_10599179", "reactome": "R-DDI-1678841", "name": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597190" ], "products": [ "species_10597188", "species_141681" ], "modifiers": [ [ "species_10599176", "catalyst" ] ], "additional_components": [ "Q54CI1", "DDB_G0292984", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q54TE1", "DDB_G0281833", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q54TE1", "DDB_G0281833", "Q54DT4", "DDB_G0292046", "Q553T4", "DDB_G0275415" ] }, "reaction_10599226": { "compartment": "compartment_70101", "id": "reaction_10599226", "reactome": "R-DDI-1678843", "name": "ISGylation of protein translation regulator 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597149", "species_10599206" ], "products": [ "species_10599208" ], "modifiers": [], "additional_components": [ "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043", "B0G0Z1", "DDB_G0284841", "Q54E38", "DDB_G0291820", "Q55BQ5", "DDB_G0284841", "Q54P37", "DDB_G0284841", "Q54T63", "DDB_G0284841", "B0G0Z1", "DDB_G0284841", "Q54E38", "DDB_G0291820", "Q55BQ5", "DDB_G0284841", "Q54P37", "DDB_G0284841", "Q54T63", "DDB_G0284841", "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043" ] }, "reaction_10597165": { "compartment": "compartment_70101", "id": "reaction_10597165", "reactome": "R-DDI-1169402", "name": "ISGylation of E2 conjugating enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597149", "species_113592", "species_10597160" ], "products": [ "species_111294", "species_10597162", "species_10597147", "species_10595031", "species_76577" ], "modifiers": [ [ "species_10597149", "catalyst" ] ], "additional_components": [ "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043", "Q86K32", "DDB_G0277267", "Q54TE1", "DDB_G0281833", "Q54CI1", "DDB_G0292984", "Q86K32", "DDB_G0277267", "Q54TE1", "DDB_G0281833", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043", "DDB_G0281833", "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043" ] }, "reaction_10597167": { "compartment": "compartment_70101", "id": "reaction_10597167", "reactome": "R-DDI-1169403", "name": "Interaction of E3 ligase with ISG15:E2 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597147", "species_10597143" ], "products": [ "species_10597149" ], "modifiers": [], "additional_components": [ "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043", "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043" ] }, "reaction_10594178": { "compartment": "compartment_13231", "id": "reaction_10594178", "reactome": "R-DDI-873917", "name": "Translocation of STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594164" ], "products": [ "species_10594176" ], "modifiers": [], "additional_components": [ "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167" ] }, "reaction_10594217": { "compartment": "compartment_7660", "id": "reaction_10594217", "reactome": "R-DDI-877281", "name": "PIAS1 binds p-STAT1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594201", "species_10594213", "species_10594176" ], "products": [ "species_10594215" ], "modifiers": [], "additional_components": [ "Q54V57", "DDB_G0280603", "Q555X5", "DDB_G0274743", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q54V57", "DDB_G0280603", "Q555X5", "DDB_G0274743" ] }, "reaction_10612656": { "compartment": "compartment_70101", "id": "reaction_10612656", "reactome": "R-DDI-6786293", "name": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612625" ], "products": [ "species_10612654" ], "modifiers": [], "additional_components": [ "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381" ] }, "reaction_10612627": { "compartment": "compartment_70101", "id": "reaction_10612627", "reactome": "R-DDI-6786097", "name": "p-Y705-STAT3, p-Y641-STAT6 dimerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612621" ], "products": [ "species_10612625" ], "modifiers": [], "additional_components": [ "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638" ] }, "reaction_10612900": { "compartment": "compartment_17957", "id": "reaction_10612900", "reactome": "R-DDI-6790038", "name": "Expression of HSP90B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10612898" ], "modifiers": [ [ "species_10597019", "catalyst" ] ], "additional_components": [ "DDB_G0280057", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381" ] }, "reaction_10612808": { "compartment": "compartment_70101", "id": "reaction_10612808", "reactome": "R-DDI-6788622", "name": "p-Y-STATs dimerize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612804" ], "products": [ "species_10612806" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167" ] }, "reaction_10612812": { "compartment": "compartment_70101", "id": "reaction_10612812", "reactome": "R-DDI-6788623", "name": "p-Y-STATs translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612806" ], "products": [ "species_10612810" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381" ] }, "reaction_10592978": { "compartment": "compartment_984", "id": "reaction_10592978", "reactome": "R-DDI-449117", "name": "TXLNA (IL14) binds syntaxin1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10592964", "species_10592962" ], "products": [ "species_10592966" ], "modifiers": [ [ "species_10592976", "inhibitor" ] ], "additional_components": [ "DDB_G0289379", "DDB_G0290231", "Q54GD1", "DDB_G0290231", "Q54HM5", "DDB_G0289379", "Q54HM5", "DDB_G0289379", "Q54QC8", "DDB_G0283937", "Q54ZW8", "DDB_G0277343", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590" ] }, "reaction_10624948": { "compartment": "compartment_984", "id": "reaction_10624948", "reactome": "R-DDI-9014052", "name": "TXLNA (IL14) binds syntaxin3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10592962", "species_10624944" ], "products": [ "species_10624946" ], "modifiers": [], "additional_components": [ "DDB_G0290231", "Q55DR2", "DDB_G0270556", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556", "Q54HM5", "DDB_G0289379", "Q54GD1", "DDB_G0290231" ] }, "reaction_10624952": { "compartment": "compartment_984", "id": "reaction_10624952", "reactome": "R-DDI-9014074", "name": "TXLNA (IL14) binds syntaxin4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589716", "species_10592962" ], "products": [ "species_10624950" ], "modifiers": [], "additional_components": [ "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556", "DDB_G0290231", "Q54GD1", "DDB_G0290231", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556" ] }, "reaction_10593044": { "compartment": "compartment_70101", "id": "reaction_10593044", "reactome": "R-DDI-450296", "name": "Phosphorylated MKK3/MKK6 migrates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593036" ], "products": [ "species_10593042" ], "modifiers": [], "additional_components": [ "Q54HS0", "DDB_G0289277", "Q54HS0", "DDB_G0289277" ] }, "reaction_10593080": { "compartment": "compartment_70101", "id": "reaction_10593080", "reactome": "R-DDI-450346", "name": "activated human TAK1 phosphorylates MKK3/MKK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10593078" ], "products": [ "species_10593036", "species_29370" ], "modifiers": [ [ "species_10593069", "catalyst" ] ], "additional_components": [ "Q54HS0", "DDB_G0289277", "Q54HS0", "DDB_G0289277", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54FC5", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "P11467", "DDB_G0290961", "Q1ZXR0", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54LU8", "DDB_G0286465" ] }, "reaction_10587141": { "compartment": "compartment_7660", "id": "reaction_10587141", "reactome": "R-DDI-198746", "name": "ERK1/2/5 activate RSK1/2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10587082" ], "products": [ "species_113582", "species_10587136" ], "modifiers": [ [ "species_10587138", "catalyst" ] ], "additional_components": [ "Q8MYF1", "DDB_G0277449", "P34102", "DDB_G0286125", "P34102", "DDB_G0286125", "Q8MYF1", "DDB_G0277449", "P42525", "DDB_G0286353" ] }, "reaction_10587284": { "compartment": "compartment_7660", "id": "reaction_10587284", "reactome": "R-DDI-199959", "name": "ERKs are inactivated by protein phosphatase 2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10587138" ], "products": [ "species_113550", "species_10587274" ], "modifiers": [ [ "species_10587281", "catalyst" ] ], "additional_components": [ "P42525", "DDB_G0286353", "P42525", "DDB_G0286353", "Q54VB6", "DDB_G0280469" ] }, "reaction_10587820": { "compartment": "compartment_7660", "id": "reaction_10587820", "reactome": "R-DDI-203797", "name": "ERKs are inactivated by dual-specific phosphatases (DUSPs)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10587138" ], "products": [ "species_113550", "species_10587274" ], "modifiers": [ [ "species_10587817", "catalyst" ] ], "additional_components": [ "P42525", "DDB_G0286353", "P42525", "DDB_G0286353", "Q55BI8", "DDB_G0285449", "Q54N84", "DDB_G0285449", "Q54Y32", "DDB_G0278445", "Q556Y8", "DDB_G0285449" ] }, "reaction_10593072": { "compartment": "compartment_70101", "id": "reaction_10593072", "reactome": "R-DDI-450337", "name": "Activated TAK1 phosphorylates MKK4/MKK7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593050", "species_113592" ], "products": [ "species_29370", "species_10593060" ], "modifiers": [ [ "species_10593069", "catalyst" ] ], "additional_components": [ "Q54HS0", "DDB_G0289277", "Q54HS0", "DDB_G0289277", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54FC5", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "P11467", "DDB_G0290961", "Q1ZXR0", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54LU8", "DDB_G0286465" ] }, "reaction_10624354": { "compartment": "compartment_70101", "id": "reaction_10624354", "reactome": "R-DDI-8983373", "name": "p-Y-STAT3 binds p-STAT5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624350", "species_10624340" ], "products": [ "species_10624352" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167" ] }, "reaction_10624388": { "compartment": "compartment_70101", "id": "reaction_10624388", "reactome": "R-DDI-8983379", "name": "p-Y-STAT3:p-STAT5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624352" ], "products": [ "species_10624386" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "Q54BD4", "DDB_G0293532", "O00910", "DDB_G0281381", "Q86I20", "DDB_G0275167", "Q70GP4", "DDB_G0268638" ] }, "reaction_10624407": { "compartment": "compartment_70101", "id": "reaction_10624407", "reactome": "R-DDI-8985943", "name": "p-Y701-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624403" ], "products": [ "species_10624405" ], "modifiers": [], "additional_components": [ "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532" ] }, "reaction_10624411": { "compartment": "compartment_70101", "id": "reaction_10624411", "reactome": "R-DDI-8985950", "name": "p-Y649-STAT5A, p-STAT5B dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624340" ], "products": [ "species_10624409" ], "modifiers": [], "additional_components": [] }, "reaction_10624415": { "compartment": "compartment_70101", "id": "reaction_10624415", "reactome": "R-DDI-8985966", "name": "p-Y701-STAT1 binds p-Y705-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624350", "species_10624403" ], "products": [ "species_10624413" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532" ] }, "reaction_10624429": { "compartment": "compartment_70101", "id": "reaction_10624429", "reactome": "R-DDI-8985981", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624413" ], "products": [ "species_10624427" ], "modifiers": [], "additional_components": [ "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q54BD4", "DDB_G0293532", "O00910", "DDB_G0281381", "Q86I20", "DDB_G0275167", "Q70GP4", "DDB_G0268638" ] }, "reaction_10597005": { "compartment": "compartment_70101", "id": "reaction_10597005", "reactome": "R-DDI-1112538", "name": "Phosphorylated STAT1, STAT3 form dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596997" ], "products": [ "species_10597003" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167" ] }, "reaction_10597023": { "compartment": "compartment_70101", "id": "reaction_10597023", "reactome": "R-DDI-1112587", "name": "STAT1 and STAT3 dimers translocate to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597003" ], "products": [ "species_10597021" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381" ] }, "reaction_10624538": { "compartment": "compartment_70101", "id": "reaction_10624538", "reactome": "R-DDI-9009072", "name": "STAT3 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10589922" ], "products": [ "species_10624350", "species_29370" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q86I20", "DDB_G0275167", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167" ] }, "reaction_10593345": { "compartment": "compartment_70101", "id": "reaction_10593345", "reactome": "R-DDI-451418", "name": "Pellino ubiquitinates IRAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593334" ], "products": [ "species_10593342" ], "modifiers": [ [ "species_10593334", "catalyst" ] ], "additional_components": [ "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54D06", "DDB_G0292596", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54LU8", "DDB_G0286465", "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54D06", "DDB_G0292596" ] }, "reaction_10593026": { "compartment": "compartment_70101", "id": "reaction_10593026", "reactome": "R-DDI-450173", "name": "IRAK1 induces oligomerisation of TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10592841", "species_10584497" ], "products": [ "species_10592843" ], "modifiers": [], "additional_components": [ "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54LU8", "DDB_G0286465" ] }, "reaction_10623333": { "compartment": "compartment_70101", "id": "reaction_10623333", "reactome": "R-DDI-8948015", "name": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10592845", "species_10592843" ], "products": [ "species_10592847" ], "modifiers": [], "additional_components": [ "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54D06", "DDB_G0292596", "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54D06", "DDB_G0292596" ] }, "reaction_10592922": { "compartment": "compartment_70101", "id": "reaction_10592922", "reactome": "R-DDI-446877", "name": "TRAF6 is K63 poly-ubiquitinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10592847" ], "products": [ "species_10592919" ], "modifiers": [ [ "species_10592847", "catalyst" ] ], "additional_components": [ "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54D06", "DDB_G0292596", "Q54FC5", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "P11467", "DDB_G0290961", "Q1ZXR0", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54D06", "DDB_G0292596" ] }, "reaction_10623337": { "compartment": "compartment_70101", "id": "reaction_10623337", "reactome": "R-DDI-8948018", "name": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10592919" ], "products": [ "species_10587623", "species_10623335" ], "modifiers": [], "additional_components": [ "Q54FC5", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "P11467", "DDB_G0290961", "Q1ZXR0", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54FC5", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "P11467", "DDB_G0290961", "Q1ZXR0", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54LU8", "DDB_G0286465" ] }, "reaction_10593870": { "compartment": "compartment_70101", "id": "reaction_10593870", "reactome": "R-DDI-507719", "name": "p62:MEKK3 binds to TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593866", "species_10584497" ], "products": [ "species_10593868" ], "modifiers": [], "additional_components": [ "Q55CE3", "DDB_G0270098", "Q54PX0", "DDB_G0284251", "Q55CA6", "DDB_G0284251", "Q8T2I8", "DDB_G0276465", "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q55CE3", "DDB_G0270098", "Q54PX0", "DDB_G0284251", "Q55CA6", "DDB_G0284251", "Q8T2I8", "DDB_G0276465" ] }, "reaction_10619777": { "compartment": "compartment_7660", "id": "reaction_10619777", "reactome": "R-DDI-8865605", "name": "BRWD1 binds SMARCA4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. 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For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619773", "species_10602136" ], "products": [ "species_10619775" ], "modifiers": [], "additional_components": [ "DDB_G0285837", "DDB_G0271052", "Q55C32", "DDB_G0271052", "Q54MP8", "DDB_G0285837" ] }, "reaction_10619802": { "compartment": "compartment_7660", "id": "reaction_10619802", "reactome": "R-DDI-8865613", "name": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619773", "species_10619780" ], "products": [ "species_10619800" ], "modifiers": [], "additional_components": [ "DDB_G0285837", "DDB_G0291185", "Q54F38", "DDB_G0291185", "Q54MP8", "DDB_G0285837" ] }, "reaction_10623473": { "compartment": "compartment_70101", "id": "reaction_10623473", "reactome": "R-DDI-8950724", "name": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596995", "species_10594320" ], "products": [ "species_10597001" ], "modifiers": [], "additional_components": [ "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167" ] }, "reaction_10623477": { "compartment": "compartment_70101", "id": "reaction_10623477", "reactome": "R-DDI-8950778", "name": "p-Y693-STAT4 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623421" ], "products": [ "species_10623423" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "Q70GP4", "DDB_G0268638", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "Q70GP4", "DDB_G0268638" ] }, "reaction_10623437": { "compartment": "compartment_70101", "id": "reaction_10623437", "reactome": "R-DDI-8950181", "name": "Y693-STAT4 dimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623423" ], "products": [ "species_10623435" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "O00910", "DDB_G0281381", "Q86I20", "DDB_G0275167", "Q70GP4", "DDB_G0268638" ] }, "reaction_10624465": { "compartment": "compartment_70101", "id": "reaction_10624465", "reactome": "R-DDI-8987007", "name": "p-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623451" ], "products": [ "species_10624463" ], "modifiers": [], "additional_components": [ "Q54BD4", "DDB_G0293532", "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q54BD4", "DDB_G0293532", "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167" ] }, "reaction_10612568": { "compartment": "compartment_70101", "id": "reaction_10612568", "reactome": "R-DDI-6784763", "name": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596999" ], "products": [ "species_10597019" ], "modifiers": [], "additional_components": [ "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381" ] }, "reaction_10624491": { "compartment": "compartment_70101", "id": "reaction_10624491", "reactome": "R-DDI-8987052", "name": "p-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624477" ], "products": [ "species_10624489" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381" ] }, "reaction_10612570": { "compartment": "compartment_70101", "id": "reaction_10612570", "reactome": "R-DDI-6784765", "name": "p-Y705-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596995" ], "products": [ "species_10596999" ], "modifiers": [], "additional_components": [ "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638" ] }, "reaction_10624495": { "compartment": "compartment_70101", "id": "reaction_10624495", "reactome": "R-DDI-8987214", "name": "p-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624475" ], "products": [ "species_10624477" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167" ] }, "reaction_10624509": { "compartment": "compartment_70101", "id": "reaction_10624509", "reactome": "R-DDI-8987218", "name": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624463" ], "products": [ "species_10624507" ], "modifiers": [], "additional_components": [ "Q54BD4", "DDB_G0293532", "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q54BD4", "DDB_G0293532", "O00910", "DDB_G0281381", "Q86I20", "DDB_G0275167", "Q70GP4", "DDB_G0268638" ] }, "reaction_10603411": { "compartment": "compartment_876", "id": "reaction_10603411", "reactome": "R-DDI-3928619", "name": "PAK1 binds RAC1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590366", "species_10588143" ], "products": [ "species_10603409" ], "modifiers": [], "additional_components": [ "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "P34144", "DDB_G0277869", "species_29438", "P34144", "DDB_G0277869", "species_29438", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459" ] }, "reaction_10603426": { "compartment": "compartment_70101", "id": "reaction_10603426", "reactome": "R-DDI-3928620", "name": "PAK1 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10603409" ], "products": [ "species_10603423", "species_29370" ], "modifiers": [ [ "species_10603409", "catalyst" ] ], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459", "P34144", "DDB_G0277869", "species_29438", "P34144", "DDB_G0277869", "species_29438", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459" ] }, "reaction_10611057": { "compartment": "compartment_161320", "id": "reaction_10611057", "reactome": "R-DDI-5690517", "name": "PPT1 hydrolyses palmitoylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_5690533" ], "products": [ "species_6785219", "species_5690516" ], "modifiers": [ [ "species_10611054", "catalyst" ] ], "additional_components": [ "species_3632881", "species_6785219", "DDB_G0285533" ] }, "reaction_10624098": { "compartment": "compartment_5460", "id": "reaction_10624098", "reactome": "R-DDI-8957389", "name": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8957387" ], "products": [ "species_8957386", "species_113521" ], "modifiers": [ [ "species_10624095", "catalyst" ] ], "additional_components": [ "DDB_G0281965" ] }, "reaction_10593969": { "compartment": "compartment_70101", "id": "reaction_10593969", "reactome": "R-DDI-548800", "name": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_548819", "species_29508" ], "products": [ "species_113528", "species_548816", "species_76194" ], "modifiers": [ [ "species_10593966", "catalyst" ] ], "additional_components": [ "Q55BY4", "DDB_G0271066", "C7FZW5", "DDB_G0271066" ] }, "reaction_10593985": { "compartment": "compartment_70101", "id": "reaction_10593985", "reactome": "R-DDI-548818", "name": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_548812" ], "products": [ "species_548836", "species_29366" ], "modifiers": [ [ "species_10593982", "catalyst" ] ], "additional_components": [ "Q869Y3", "DDB_G0275049" ] }, "reaction_10593995": { "compartment": "compartment_70101", "id": "reaction_10593995", "reactome": "R-DDI-548831", "name": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_548809" ], "products": [ "species_428139", "species_29366" ], "modifiers": [ [ "species_10593990", "catalyst" ] ], "additional_components": [ "DDB_G0270270" ] }, "reaction_10593978": { "compartment": "compartment_70101", "id": "reaction_10593978", "reactome": "R-DDI-548814", "name": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29508", "species_200993" ], "products": [ "species_113528", "species_548812", "species_76194" ], "modifiers": [ [ "species_10593975", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10587452": { "compartment": "compartment_70101", "id": "reaction_10587452", "reactome": "R-DDI-201035", "name": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_3632881", "species_76194" ], "products": [ "species_111294", "species_29356", "species_200993", "species_76577" ], "modifiers": [ [ "species_10587449", "catalyst" ] ], "additional_components": [ "Q54JK0", "DDB_G0288001", "Q55DR6", "DDB_G0269242", "Q1ZXQ4", "DDB_G0269474" ] }, "reaction_10593980": { "compartment": "compartment_70101", "id": "reaction_10593980", "reactome": "R-DDI-548815", "name": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29508", "species_548794" ], "products": [ "species_113528", "species_548829", "species_76194" ], "modifiers": [ [ "species_10593975", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10607615": { "compartment": "compartment_12045", "id": "reaction_10607615", "reactome": "R-DDI-5676637", "name": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676631" ], "products": [ "species_29356", "species_5676634" ], "modifiers": [ [ "species_10607612", "catalyst" ] ], "additional_components": [ "Q54Y54", "DDB_G0278683", "Q54YR9", "DDB_G0278113" ] }, "reaction_10611854": { "compartment": "compartment_70101", "id": "reaction_10611854", "reactome": "R-DDI-5695957", "name": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_5695985", "species_76194" ], "products": [ "species_111294", "species_5695971", "species_76577" ], "modifiers": [ [ "species_10611851", "catalyst" ] ], "additional_components": [ "Q55CD5", "DDB_G0270106" ] }, "reaction_10611870": { "compartment": "compartment_5460", "id": "reaction_10611870", "reactome": "R-DDI-5696007", "name": "ACSF3 ligates CoA-SH to VLCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_5696008", "species_113593" ], "products": [ "species_159448", "species_159450", "species_5696003" ], "modifiers": [ [ "species_10611867", "catalyst" ] ], "additional_components": [ "DDB_G0289539" ] }, "reaction_10587362": { "compartment": "compartment_70101", "id": "reaction_10587362", "reactome": "R-DDI-200555", "name": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_113592", "species_76183" ], "products": [ "species_29372", "species_29370", "species_29508" ], "modifiers": [ [ "species_10581617", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "DDB_G0288387" ] }, "reaction_10581606": { "compartment": "compartment_70101", "id": "reaction_10581606", "reactome": "R-DDI-75848", "name": "ACLY tetramer transforms CIT to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76190", "species_113592", "species_76194" ], "products": [ "species_29372", "species_29370", "species_76183", "species_76213" ], "modifiers": [ [ "species_10581603", "catalyst" ] ], "additional_components": [ "Q54YA2", "DDB_G0278341" ] }, "reaction_10581675": { "compartment": "compartment_70101", "id": "reaction_10581675", "reactome": "R-DDI-75872", "name": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_76183", "species_29364", "species_29508" ], "products": [ "species_29356", "species_113528", "species_29366", "species_3632881", "species_76194" ], "modifiers": [ [ "species_10581672", "catalyst" ] ], "additional_components": [ "Q869X2", "DDB_G0275077", "Q55E72", "DDB_G0269364", "Q869W9", "DDB_G0275069" ] }, "reaction_10584076": { "compartment": "compartment_70101", "id": "reaction_10584076", "reactome": "R-DDI-163756", "name": "Formation of fatty acid synthase (FAS) dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581670" ], "products": [ "species_10581672" ], "modifiers": [], "additional_components": [ "Q869X2", "DDB_G0275077", "Q55E72", "DDB_G0269364", "Q869W9", "DDB_G0275069", "Q869X2", "DDB_G0275077", "Q55E72", "DDB_G0269364", "Q869W9", "DDB_G0275069" ] }, "reaction_10625008": { "compartment": "compartment_70101", "id": "reaction_10625008", "reactome": "R-DDI-9014641", "name": "HRSP12 deaminates 2AA to 2OBUTA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9014643" ], "products": [ "species_29382", "species_936714" ], "modifiers": [ [ "species_10625005", "catalyst" ] ], "additional_components": [ "DDB_G0277761" ] }, "reaction_10625000": { "compartment": "compartment_70101", "id": "reaction_10625000", "reactome": "R-DDI-9014627", "name": "SDS dimers:PXLP dehydrate L-Thr to 2AA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351990" ], "products": [ "species_29356", "species_9014643" ], "modifiers": [ [ "species_10624997", "catalyst" ] ], "additional_components": [ "Q86B06", "DDB_G0272787" ] }, "reaction_10585185": { "compartment": "compartment_876", "id": "reaction_10585185", "reactome": "R-DDI-170986", "name": "Ral-GDS binds to Ras-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585181", "species_10585144" ], "products": [ "species_10585183" ], "modifiers": [], "additional_components": [ "Q8IS18", "DDB_G0269252", "Q54WL2", "DDB_G0279569", "Q552M5", "DDB_G0276019", "Q8IS19", "DDB_G0289667", "Q8SSQ3", "DDB_G0274607", "Q54L90", "DDB_G0286773", "Q86G47", "DDB_G0289665", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q8IS18", "DDB_G0269252", "Q54WL2", "DDB_G0279569", "Q552M5", "DDB_G0276019", "Q8IS19", "DDB_G0289667", "Q8SSQ3", "DDB_G0274607", "Q54L90", "DDB_G0286773", "Q86G47", "DDB_G0289665" ] }, "reaction_10626117": { "compartment": "compartment_7660", "id": "reaction_10626117", "reactome": "R-DDI-9612509", "name": "SGK phosphorylates SRF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10626105" ], "products": [ "species_113582", "species_10626108" ], "modifiers": [ [ "species_10626114", "catalyst" ] ], "additional_components": [ "DDB_G0281387", "DDB_G0281387", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620" ] }, "reaction_10587062": { "compartment": "compartment_7660", "id": "reaction_10587062", "reactome": "R-DDI-198714", "name": "ERK5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587058" ], "products": [ "species_10587060" ], "modifiers": [], "additional_components": [ "DDB_G0286353", "DDB_G0286353" ] }, "reaction_10591923": { "compartment": "compartment_70101", "id": "reaction_10591923", "reactome": "R-DDI-430021", "name": "PAN2-PAN3 complex partially deadenylates mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10591908" ], "products": [ "species_10591904", "species_76577" ], "modifiers": [ [ "species_10591920", "catalyst" ] ], "additional_components": [ "Q75K16", "DDB_G0275459", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "Q54BM2", "DDB_G0293558", "Q55D61", "DDB_G0269192", "P90529", "DDB_G0269146", "Q75K16", "DDB_G0275459", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "Q54BM2", "DDB_G0293558", "Q55D61", "DDB_G0269192", "P90529", "DDB_G0269146", "Q55DD5", "DDB_G0269694", "P0CD65", "DDB_G0279129" ] }, "reaction_10623223": { "compartment": "compartment_70101", "id": "reaction_10623223", "reactome": "R-DDI-8941312", "name": "ZCCHC6, ZCCHC11 are mRNA uridyltransferases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6782337", "species_10591904" ], "products": [ "species_10623193" ], "modifiers": [ [ "species_10623220", "catalyst" ] ], "additional_components": [ "Q75K16", "DDB_G0275459", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "Q54BM2", "DDB_G0293558", "Q55D61", "DDB_G0269192", "P90529", "DDB_G0269146", "species_6782337", "Q75K16", "DDB_G0275459", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "Q54BM2", "DDB_G0293558", "Q55D61", "DDB_G0269192", "P90529", "DDB_G0269146", "Q8T2J7", "DDB_G0281431", "Q54Y43", "DDB_G0281431", "Q54TZ1", "DDB_G0281431" ] }, "reaction_10625515": { "compartment": "compartment_70101", "id": "reaction_10625515", "reactome": "R-DDI-9026005", "name": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9026293", "species_29368" ], "products": [ "species_9026311" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625519": { "compartment": "compartment_70101", "id": "reaction_10625519", "reactome": "R-DDI-9026007", "name": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9025012", "species_29366" ], "products": [ "species_9026307", "species_29364" ], "modifiers": [ [ "species_10600421", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10625517": { "compartment": "compartment_70101", "id": "reaction_10625517", "reactome": "R-DDI-9026006", "name": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9608444", "species_29368" ], "products": [ "species_9026293" ], "modifiers": [ [ "species_10600421", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10587587": { "compartment": "compartment_70101", "id": "reaction_10587587", "reactome": "R-DDI-202127", "name": "eNOS synthesizes NO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468", "species_29368", "species_29364" ], "products": [ "species_202124", "species_29366", "species_29968" ], "modifiers": [ [ "species_10587584", "catalyst" ], [ "species_5693375", "inhibitor" ] ], "additional_components": [ "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "P54651", "DDB_G0267400", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_29870" ] }, "reaction_10587763": { "compartment": "compartment_876", "id": "reaction_10587763", "reactome": "R-DDI-203613", "name": "depalmitoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587546" ], "products": [ "species_76168", "species_10587591" ], "modifiers": [ [ "species_10587760", "catalyst" ] ], "additional_components": [ "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_917877", "species_29426", "Q55CT1", "DDB_G0269912", "species_76629", "species_113596", "species_29870", "Q54T49", "DDB_G0282005" ] }, "reaction_10587749": { "compartment": "compartment_20699", "id": "reaction_10587749", "reactome": "R-DDI-203567", "name": "palmitoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587589", "species_200993" ], "products": [ "species_10587719" ], "modifiers": [ [ "species_10587746", "catalyst" ] ], "additional_components": [ "DDB_G0269912", "DDB_G0269912", "Q54VH7", "DDB_G0293930", "Q86A83", "DDB_G0293930", "Q552M6", "DDB_G0293930", "Q555N7", "DDB_G0293930", "Q54B34", "DDB_G0293930" ] }, "reaction_10598261": { "compartment": "compartment_70101", "id": "reaction_10598261", "reactome": "R-DDI-1497784", "name": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_10587580" ], "products": [ "species_10587584" ], "modifiers": [], "additional_components": [ "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "P54651", "DDB_G0267400", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_29870", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "P54651", "DDB_G0267400", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_29870" ] }, "reaction_10598276": { "compartment": "compartment_70101", "id": "reaction_10598276", "reactome": "R-DDI-1497869", "name": "Salvage - Sepiapterin is reduced to BH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_1497811", "species_29364" ], "products": [ "species_1497857", "species_29366" ], "modifiers": [ [ "species_10597898", "catalyst" ] ], "additional_components": [ "Q54GP3", "DDB_G0290009" ] }, "reaction_10587753": { "compartment": "compartment_70101", "id": "reaction_10587753", "reactome": "R-DDI-203611", "name": "N-myristoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_184174", "species_10587751" ], "products": [ "species_10587589" ], "modifiers": [], "additional_components": [ "DDB_G0269912", "DDB_G0269912" ] }, "reaction_10598265": { "compartment": "compartment_70101", "id": "reaction_10598265", "reactome": "R-DDI-1497796", "name": "BH2 binding can lead to eNOS uncoupling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1497857", "species_10587584" ], "products": [ "species_29870", "species_10598263" ], "modifiers": [], "additional_components": [ "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "P54651", "DDB_G0267400", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_29870", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "P54651", "DDB_G0267400", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_1497857", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_29870" ] }, "reaction_10587773": { "compartment": "compartment_20699", "id": "reaction_10587773", "reactome": "R-DDI-203700", "name": "eNOS translocation from Golgi to Caveolae", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587719" ], "products": [ "species_10587546" ], "modifiers": [], "additional_components": [ "DDB_G0269912", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596" ] }, "reaction_10587597": { "compartment": "compartment_20699", "id": "reaction_10587597", "reactome": "R-DDI-202132", "name": "depalmitoylated eNOS translocates from plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587591" ], "products": [ "species_10587595" ], "modifiers": [], "additional_components": [ "species_917877", "species_29426", "Q55CT1", "DDB_G0269912", "species_76629", "species_113596", "species_29870", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_29870" ] }, "reaction_10598268": { "compartment": "compartment_70101", "id": "reaction_10598268", "reactome": "R-DDI-1497810", "name": "Uncoupled eNOS favours the formation of superoxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29364" ], "products": [ "species_1222424", "species_29366" ], "modifiers": [ [ "species_10598263", "catalyst" ] ], "additional_components": [ "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "P54651", "DDB_G0267400", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_1497857", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_29870" ] }, "reaction_10587599": { "compartment": "compartment_70101", "id": "reaction_10587599", "reactome": "R-DDI-202137", "name": "AKT1 binds eNOS complex via HSP90", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587563", "species_10586949" ], "products": [ "species_10587571" ], "modifiers": [], "additional_components": [ "Q7Z2B8", "DDB_G0277917", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "species_74112", "P54651", "DDB_G0267400", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "Q7Z2B8", "DDB_G0277917", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "species_74112", "P54651", "DDB_G0267400", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596" ] }, "reaction_10587582": { "compartment": "compartment_70101", "id": "reaction_10587582", "reactome": "R-DDI-202111", "name": "AKT1 phosphorylates eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10587571" ], "products": [ "species_10587580", "species_29370" ], "modifiers": [], "additional_components": [ "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "Q7Z2B8", "DDB_G0277917", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "species_74112", "P54651", "DDB_G0267400", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "P54651", "DDB_G0267400", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_29870" ] }, "reaction_10592001": { "compartment": "compartment_70101", "id": "reaction_10592001", "reactome": "R-DDI-430028", "name": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429974" ], "products": [ "species_109402", "species_113578", "species_109395", "species_429926", "species_76577" ], "modifiers": [ [ "species_10591998", "catalyst" ] ], "additional_components": [ "Q54HV0", "DDB_G0289175", "Q54S59", "DDB_G0282793", "Q86K90", "DDB_G0277211", "Q55BJ2", "DDB_G0271100", "Q54VM4", "DDB_G0280251", "Q54CU6", "DDB_G0292692", "Q55BB0", "DDB_G0271396", "Q54EU6", "DDB_G0291328", "Q54Q83", "DDB_G0284053", "Q54EV5", "DDB_G0291310", "Q54N99", "DDB_G0285377", "Q54BH9", "DDB_G0293614", "Q7KWX9", "DDB_G0276783", "Q54QJ0", "DDB_G0283769" ] }, "reaction_10597571": { "compartment": "compartment_7660", "id": "reaction_10597571", "reactome": "R-DDI-1363311", "name": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597257", "species_10597559" ], "products": [ "species_10597569" ], "modifiers": [], "additional_components": [ "Q54FX2", "DDB_G0290551", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "P34112", "DDB_G0272813", "P34112", "DDB_G0272813", "Q54FX2", "DDB_G0290551", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129" ] }, "reaction_10597575": { "compartment": "compartment_7660", "id": "reaction_10597575", "reactome": "R-DDI-1363314", "name": "p107 (RBL1) binds CyclinE/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597559", "species_10597255" ], "products": [ "species_10597573" ], "modifiers": [], "additional_components": [ "P34112", "DDB_G0272813", "DDB_G0290551", "Q54FX2", "DDB_G0290551", "P34112", "DDB_G0272813" ] }, "reaction_10597563": { "compartment": "compartment_7660", "id": "reaction_10597563", "reactome": "R-DDI-1363303", "name": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597246", "species_10597559" ], "products": [ "species_10597561" ], "modifiers": [], "additional_components": [ "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551", "Q7KWP1", "DDB_G0276799", "P34112", "DDB_G0272813", "P34112", "DDB_G0272813", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551", "Q7KWP1", "DDB_G0276799" ] }, "reaction_10597274": { "compartment": "compartment_7660", "id": "reaction_10597274", "reactome": "R-DDI-1227670", "name": "Recruitment of HDAC1 by p130 (RBL2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597246", "species_10597270" ], "products": [ "species_10597272" ], "modifiers": [], "additional_components": [ "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551", "Q7KWP1", "DDB_G0276799", "DDB_G0268024", "Q55FN5", "DDB_G0268024", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551", "Q7KWP1", "DDB_G0276799" ] }, "reaction_10597567": { "compartment": "compartment_7660", "id": "reaction_10597567", "reactome": "R-DDI-1363306", "name": "p130 (RBL2) binds Cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597229", "species_10597559" ], "products": [ "species_10597565" ], "modifiers": [], "additional_components": [ "DDB_G0290551", "P34112", "DDB_G0272813", "P34112", "DDB_G0272813", "Q54FX2", "DDB_G0290551" ] }, "reaction_10597278": { "compartment": "compartment_7660", "id": "reaction_10597278", "reactome": "R-DDI-1227671", "name": "Recruitment of HDAC1 by p107 (RBL1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597257", "species_10597270" ], "products": [ "species_10597276" ], "modifiers": [], "additional_components": [ "Q54FX2", "DDB_G0290551", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "DDB_G0268024", "Q55FN5", "DDB_G0268024", "Q54FX2", "DDB_G0290551", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129" ] }, "reaction_10586837": { "compartment": "compartment_70101", "id": "reaction_10586837", "reactome": "R-DDI-196929", "name": "FLAD1 phosphorylates FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_73524" ], "products": [ "species_111294", "species_29386" ], "modifiers": [ [ "species_10586834", "catalyst" ] ], "additional_components": [ "DDB_G0282955" ] }, "reaction_10586847": { "compartment": "compartment_70101", "id": "reaction_10586847", "reactome": "R-DDI-196955", "name": "2xENPP1 hydrolyzes FAD to FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29386" ], "products": [ "species_73524", "species_76577" ], "modifiers": [ [ "species_10586844", "catalyst" ] ], "additional_components": [ "Q54MJ8", "DDB_G0285897" ] }, "reaction_10604772": { "compartment": "compartment_13231", "id": "reaction_10604772", "reactome": "R-DDI-5221130", "name": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_5221122" ], "products": [ "species_113550", "species_5221124" ], "modifiers": [ [ "species_10603651", "catalyst" ] ], "additional_components": [ "Q75JA1", "DDB_G0271730" ] }, "reaction_10602755": { "compartment": "compartment_70101", "id": "reaction_10602755", "reactome": "R-DDI-3371422", "name": "ATP hydrolysis by HSP70", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602750" ], "products": [ "species_29372", "species_10602752" ], "modifiers": [ [ "species_10602750", "catalyst" ], [ "species_10602748", "catalyst" ] ], "additional_components": [ "species_113592", "P36415", "DDB_G0269144", "Q54VQ1", "DDB_G0280037", "Q54ED3", "DDB_G0291568", "species_29370", "P36415", "DDB_G0269144", "Q54VQ1", "DDB_G0280037", "Q54ED3", "DDB_G0291568", "species_113592", "P36415", "DDB_G0269144", "Q54VQ1", "DDB_G0280037", "Q54ED3", "DDB_G0291568", "Q54VQ1", "DDB_G0280037", "Q54ED3", "DDB_G0291568" ] }, "reaction_10605698": { "compartment": "compartment_70101", "id": "reaction_10605698", "reactome": "R-DDI-5618098", "name": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589012", "species_10605696" ], "products": [ "species_10602796", "species_10602861", "species_10605561" ], "modifiers": [], "additional_components": [ "DDB_G0268042", "Q54QI6", "DDB_G0283815", "species_29370", "P36415", "DDB_G0269144", "P54651", "DDB_G0267400", "species_113592", "Q54DA8", "DDB_G0292404", "DDB_G0292404", "species_113592", "P36415", "DDB_G0269144", "Q54QI6", "DDB_G0283815", "Q55FM3", "DDB_G0268042", "P54651", "DDB_G0267400", "species_113592" ] }, "reaction_10605704": { "compartment": "compartment_70101", "id": "reaction_10605704", "reactome": "R-DDI-5618099", "name": "SH binds SHR within the HSP90 chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5618094", "species_10605702" ], "products": [ "species_10605571" ], "modifiers": [], "additional_components": [ "species_193057", "species_469662", "CHEBI:16973", "CHEBI:17650", "CHEBI:27584", "species_193055", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "species_113592", "Q54QI6", "DDB_G0283815", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "species_113592", "Q54QI6", "DDB_G0283815" ] }, "reaction_10605706": { "compartment": "compartment_70101", "id": "reaction_10605706", "reactome": "R-DDI-5618105", "name": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605688", "species_10605557" ], "products": [ "species_10605696" ], "modifiers": [], "additional_components": [ "species_29370", "P36415", "DDB_G0269144", "P54651", "DDB_G0267400", "species_113592", "Q54DA8", "DDB_G0292404", "DDB_G0283815", "Q54QI6", "DDB_G0283815", "species_29370", "P36415", "DDB_G0269144", "P54651", "DDB_G0267400", "species_113592", "Q54DA8", "DDB_G0292404" ] }, "reaction_10627342": { "compartment": "compartment_70101", "id": "reaction_10627342", "reactome": "R-DDI-9678925", "name": "NR3C1 binds NR3C1 agonists", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9678859", "species_10605575" ], "products": [ "species_10627340" ], "modifiers": [], "additional_components": [ "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "species_113592", "Q54QI6", "DDB_G0283815", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "species_113592", "Q54QI6", "DDB_G0283815" ] }, "reaction_10605708": { "compartment": "compartment_70101", "id": "reaction_10605708", "reactome": "R-DDI-5618107", "name": "ATP binding to HSP90 triggers conformation change", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10602808" ], "products": [ "species_10605688" ], "modifiers": [], "additional_components": [ "P54651", "DDB_G0267400", "species_29370", "P36415", "DDB_G0269144", "Q54DA8", "DDB_G0292404", "species_29370", "P36415", "DDB_G0269144", "P54651", "DDB_G0267400", "species_113592", "Q54DA8", "DDB_G0292404" ] }, "reaction_10602863": { "compartment": "compartment_70101", "id": "reaction_10602863", "reactome": "R-DDI-3371590", "name": "HSP70 binds to HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602861", "species_10602859" ], "products": [ "species_10602750" ], "modifiers": [], "additional_components": [ "species_113592", "P36415", "DDB_G0269144", "Q54VQ1", "DDB_G0280037", "Q54ED3", "DDB_G0291568", "species_113592", "P36415", "DDB_G0269144", "Q54VQ1", "DDB_G0280037", "Q54ED3", "DDB_G0291568" ] }, "reaction_10605710": { "compartment": "compartment_70101", "id": "reaction_10605710", "reactome": "R-DDI-5618110", "name": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605690", "species_10589012" ], "products": [ "species_10602796", "species_10605565", "species_10602861" ], "modifiers": [], "additional_components": [ "species_29370", "P36415", "DDB_G0269144", "P54651", "DDB_G0267400", "species_113592", "Q54DA8", "DDB_G0292404", "Q54QI6", "DDB_G0283815", "DDB_G0268042", "DDB_G0292404", "Q55FM3", "DDB_G0268042", "P54651", "DDB_G0267400", "species_113592", "Q54QI6", "DDB_G0283815", "species_113592", "P36415", "DDB_G0269144" ] }, "reaction_10627379": { "compartment": "compartment_70101", "id": "reaction_10627379", "reactome": "R-DDI-9690534", "name": "SH binds NR3C1 (in HSP90:ATP:FKBP4:PTGES3:NR3C1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5618094", "species_10605575" ], "products": [ "species_10605577" ], "modifiers": [ [ "species_10627340", "catalyst" ] ], "additional_components": [ "species_193057", "species_469662", "CHEBI:16973", "CHEBI:17650", "CHEBI:27584", "species_193055", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "species_113592", "Q54QI6", "DDB_G0283815", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "species_113592", "Q54QI6", "DDB_G0283815", "species_193057", "species_469662", "CHEBI:16973", "CHEBI:17650", "CHEBI:27584", "species_193055", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "species_113592", "Q54QI6", "DDB_G0283815" ] }, "reaction_10605685": { "compartment": "compartment_70101", "id": "reaction_10605685", "reactome": "R-DDI-5618080", "name": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605577", "species_10605571" ], "products": [ "species_10605581", "species_10605587" ], "modifiers": [ [ "species_10605683", "catalyst" ] ], "additional_components": [ "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "species_113592", "Q54QI6", "DDB_G0283815", "species_193057", "species_469662", "CHEBI:16973", "CHEBI:17650", "CHEBI:27584", "species_193055", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "species_113592", "Q54QI6", "DDB_G0283815", "Q54QI6", "DDB_G0283815", "P54651", "DDB_G0267400", "species_113592", "Q55FM3", "DDB_G0268042", "Q54QI6", "DDB_G0283815", "P54651", "DDB_G0267400", "species_113592", "Q55FM3", "DDB_G0268042", "species_469662", "CHEBI:17650", "species_193055", "CHEBI:27584", "CHEBI:16973", "species_193057", "P54703", "DDB_G0280849", "Q86A88", "DDB_G0274815", "Q54CI8", "DDB_G0292904", "P34036", "DDB_G0276355", "Q54VD6", "DDB_G0280435", "Q54ZI7", "DDB_G0277561", "Q54N50", "DDB_G0285503", "P13021", "DDB_G0267374", "P13022", "DDB_G0272104", "Q54JY2", "DDB_G0287739", "Q54FM4", "DDB_G0290757", "Q54VS0", "DDB_G0280175", "Q54XU5", "DDB_G0278579", "Q54I79", "DDB_G0288937", "species_29438", "species_29420" ] }, "reaction_10627419": { "compartment": "compartment_70101", "id": "reaction_10627419", "reactome": "R-DDI-9705925", "name": "Androgens binds AR (in the HSP90 chaperone complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8979218", "species_10627413" ], "products": [ "species_10627417" ], "modifiers": [], "additional_components": [ "species_193057", "species_193079", "species_469662", "CHEBI:29117", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "species_113592", "Q54QI6", "DDB_G0283815", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "species_193057", "species_193079", "species_469662", "CHEBI:29117", "species_113592", "Q54QI6", "DDB_G0283815" ] }, "reaction_10602810": { "compartment": "compartment_70101", "id": "reaction_10602810", "reactome": "R-DDI-3371503", "name": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602796", "species_10602802", "species_10602752" ], "products": [ "species_10602748", "species_10602808" ], "modifiers": [], "additional_components": [ "DDB_G0292404", "P54651", "DDB_G0267400", "species_29370", "P36415", "DDB_G0269144", "Q54VQ1", "DDB_G0280037", "Q54ED3", "DDB_G0291568", "Q54VQ1", "DDB_G0280037", "Q54ED3", "DDB_G0291568", "P54651", "DDB_G0267400", "species_29370", "P36415", "DDB_G0269144", "Q54DA8", "DDB_G0292404" ] }, "reaction_10605692": { "compartment": "compartment_70101", "id": "reaction_10605692", "reactome": "R-DDI-5618085", "name": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605563", "species_10605688" ], "products": [ "species_10605690" ], "modifiers": [], "additional_components": [ "DDB_G0283815", "species_29370", "P36415", "DDB_G0269144", "P54651", "DDB_G0267400", "species_113592", "Q54DA8", "DDB_G0292404", "species_29370", "P36415", "DDB_G0269144", "P54651", "DDB_G0267400", "species_113592", "Q54DA8", "DDB_G0292404", "Q54QI6", "DDB_G0283815" ] }, "reaction_10605567": { "compartment": "compartment_70101", "id": "reaction_10605567", "reactome": "R-DDI-5618073", "name": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605563", "species_10605561" ], "products": [ "species_10605565", "species_10605557" ], "modifiers": [ [ "species_5618094", "catalyst" ] ], "additional_components": [ "DDB_G0283815", "Q54QI6", "DDB_G0283815", "Q55FM3", "DDB_G0268042", "P54651", "DDB_G0267400", "species_113592", "Q55FM3", "DDB_G0268042", "P54651", "DDB_G0267400", "species_113592", "Q54QI6", "DDB_G0283815", "DDB_G0283815", "species_193057", "species_469662", "CHEBI:16973", "CHEBI:17650", "CHEBI:27584", "species_193055" ] }, "reaction_10584784": { "compartment": "compartment_5460", "id": "reaction_10584784", "reactome": "R-DDI-169270", "name": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73663", "species_10584773" ], "products": [ "species_76633", "species_10584771" ], "modifiers": [ [ "species_10584781", "catalyst" ] ], "additional_components": [ "Q54YZ4", "DDB_G0277991", "species_31649", "species_76577", "Q54FD7", "DDB_G0290927", "Q54YZ4", "DDB_G0277991", "species_76577", "Q54FD7", "DDB_G0290927", "species_113596", "DDB_G0278849" ] }, "reaction_10612771": { "compartment": "compartment_5460", "id": "reaction_10612771", "reactome": "R-DDI-6788523", "name": "NUBPL transfers 4Fe-4S to Complex I subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612759", "species_10610755" ], "products": [ "species_10610753", "species_10612769" ], "modifiers": [], "additional_components": [ "Q54NI6", "DDB_G0285239", "Q86K57", "DDB_G0277231", "Q34312", "DDB_G0294052", "Q23883", "DDB_G0294030", "Q54F15", "DDB_G0291193", "DDB_G0291193", "Q34312", "DDB_G0294052", "Q23883", "DDB_G0294030", "Q54NI6", "DDB_G0285239", "Q86K57", "DDB_G0277231" ] }, "reaction_10612787": { "compartment": "compartment_5460", "id": "reaction_10612787", "reactome": "R-DDI-6788556", "name": "NUBPL transfers 4Fe-4S to NDUFV1, V2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612781", "species_10612776", "species_76629", "species_10610755" ], "products": [ "species_10612783", "species_10610753", "species_10612785" ], "modifiers": [], "additional_components": [ "DDB_G0291173", "DDB_G0288875", "Q54F15", "DDB_G0291193", "species_76629", "Q54I90", "DDB_G0288875", "DDB_G0291193", "Q54F10", "DDB_G0291173" ] }, "reaction_10610757": { "compartment": "compartment_5460", "id": "reaction_10610757", "reactome": "R-DDI-5690023", "name": "NUBPL binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_169274", "species_10610753" ], "products": [ "species_10610755" ], "modifiers": [], "additional_components": [ "DDB_G0291193", "Q54F15", "DDB_G0291193" ] }, "reaction_10616447": { "compartment": "compartment_5460", "id": "reaction_10616447", "reactome": "R-DDI-6800868", "name": "NDUF subunits bind to form the IP subcomplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612767", "species_10615711", "species_10612765", "species_10615723", "species_10615718" ], "products": [ "species_10615725" ], "modifiers": [], "additional_components": [ "Q86K57", "DDB_G0277231", "Q23883", "DDB_G0294030", "Q54S83", "DDB_G0282615", "Q54NI6", "DDB_G0285239", "DDB_G0294032", "Q559Z0", "DDB_G0272266", "species_113596", "Q559Z0", "DDB_G0272266", "species_113596", "P22237", "DDB_G0294032", "Q54NI6", "DDB_G0285239", "Q23883", "DDB_G0294030", "Q54S83", "DDB_G0282615", "Q86K57", "DDB_G0277231" ] }, "reaction_10584776": { "compartment": "compartment_5460", "id": "reaction_10584776", "reactome": "R-DDI-169260", "name": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584771", "species_31649" ], "products": [ "species_113596", "species_10584773" ], "modifiers": [ [ "species_10584771", "catalyst" ] ], "additional_components": [ "Q54YZ4", "DDB_G0277991", "species_76577", "Q54FD7", "DDB_G0290927", "species_113596", "Q54YZ4", "DDB_G0277991", "species_31649", "species_76577", "Q54FD7", "DDB_G0290927", "Q54YZ4", "DDB_G0277991", "species_76577", "Q54FD7", "DDB_G0290927", "species_113596" ] }, "reaction_10584136": { "compartment": "compartment_70616", "id": "reaction_10584136", "reactome": "R-DDI-164651", "name": "Electron transfer from ubiquinol to cytochrome c of complex III", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73663", "species_113529", "species_76633", "species_10584033" ], "products": [ "species_10584031", "species_73663", "species_76633", "species_163953" ], "modifiers": [ [ "species_10584133", "catalyst" ] ], "additional_components": [ "CHEBI:38574", "Q869N1", "DDB_G0275537", "CHEBI:38573", "Q869N1", "DDB_G0275537", "Q1ZXP3", "DDB_G0271774", "Q37311", "DDB_G0294078", "Q54NW9", "DDB_G0284947", "Q54V76", "DDB_G0280569", "Q4W6B5", "DDB_G0288777", "Q54M82", "DDB_G0286171", "Q54D07", "DDB_G0292594", "Q54QR8", "DDB_G0283669", "Q86A84", "DDB_G0274809" ] }, "reaction_10616628": { "compartment": "compartment_7660", "id": "reaction_10616628", "reactome": "R-DDI-6805640", "name": "AKT phosphorylates KAT6A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10616601" ], "products": [ "species_113582", "species_10616626" ], "modifiers": [ [ "species_10587267", "catalyst" ] ], "additional_components": [ "Q54QM3", "DDB_G0283859", "B0G130", "DDB_G0279699", "Q869X5", "DDB_G0279699", "Q54NG3", "DDB_G0285275", "Q54PN9", "DDB_G0284411", "Q54QM3", "DDB_G0283859", "B0G130", "DDB_G0279699", "Q869X5", "DDB_G0279699", "Q54NG3", "DDB_G0285275", "Q54PN9", "DDB_G0284411", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795" ] }, "reaction_10622674": { "compartment": "compartment_7660", "id": "reaction_10622674", "reactome": "R-DDI-8877692", "name": "PIN1 binds phosphorylated PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622667", "species_10594992" ], "products": [ "species_10622672" ], "modifiers": [], "additional_components": [ "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635", "Q86D86", "DDB_G0283615", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "DDB_G0268618", "Q55EZ0", "DDB_G0268618", "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635", "Q86D86", "DDB_G0283615", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190" ] }, "reaction_10617814": { "compartment": "compartment_7660", "id": "reaction_10617814", "reactome": "R-DDI-6811522", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6810408", "species_29358" ], "products": [ "species_113582", "species_6810412" ], "modifiers": [ [ "species_10617811", "catalyst" ] ], "additional_components": [ "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635", "Q86D86", "DDB_G0283615", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190" ] }, "reaction_10617479": { "compartment": "compartment_7660", "id": "reaction_10617479", "reactome": "R-DDI-6810376", "name": "ING2 binds PI5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6810408", "species_10603513" ], "products": [ "species_10617477" ], "modifiers": [], "additional_components": [ "DDB_G0284411", "Q54PN9", "DDB_G0284411", "species_6810408" ] }, "reaction_10622670": { "compartment": "compartment_7660", "id": "reaction_10622670", "reactome": "R-DDI-8877691", "name": "MAP2K6 phosphorylates PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10622656" ], "products": [ "species_113582", "species_10622667" ], "modifiers": [ [ "species_10593040", "catalyst" ] ], "additional_components": [ "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635", "Q86D86", "DDB_G0283615", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635", "Q86D86", "DDB_G0283615", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "DDB_G0289277" ] }, "reaction_10616616": { "compartment": "compartment_7660", "id": "reaction_10616616", "reactome": "R-DDI-6805638", "name": "KAT6A acetylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616607", "species_113560" ], "products": [ "species_2485002", "species_10616613" ], "modifiers": [ [ "species_10616607", "catalyst" ] ], "additional_components": [ "Q54QM3", "DDB_G0283859", "B0G130", "DDB_G0279699", "Q869X5", "DDB_G0279699", "Q54NG3", "DDB_G0285275", "Q54PN9", "DDB_G0284411", "Q54MF7", "DDB_G0285989", "Q54QM3", "DDB_G0283859", "B0G130", "DDB_G0279699", "Q869X5", "DDB_G0279699", "Q54NG3", "DDB_G0285275", "Q54PN9", "DDB_G0284411", "Q54MF7", "DDB_G0285989", "Q54QM3", "DDB_G0283859", "B0G130", "DDB_G0279699", "Q869X5", "DDB_G0279699", "Q54NG3", "DDB_G0285275", "Q54PN9", "DDB_G0284411", "Q54MF7", "DDB_G0285989" ] }, "reaction_10577937": { "compartment": "compartment_5460", "id": "reaction_10577937", "reactome": "R-DDI-70670", "name": "PRODH oxidises L-Pro to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113597", "species_379717" ], "products": [ "species_113529", "species_113590", "species_164934" ], "modifiers": [ [ "species_10577934", "catalyst" ] ], "additional_components": [ "DDB_G0275669" ] }, "reaction_10623999": { "compartment": "compartment_5460", "id": "reaction_10623999", "reactome": "R-DDI-8955817", "name": "PRODH2 oxidises HPRO to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113597", "species_6784215" ], "products": [ "species_113590", "species_164934", "species_113521" ], "modifiers": [ [ "species_10612516", "catalyst" ] ], "additional_components": [ "DDB_G0275669" ] }, "reaction_10597318": { "compartment": "compartment_70101", "id": "reaction_10597318", "reactome": "R-DDI-1247645", "name": "RHAG transports CO2 from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113528" ], "products": [ "species_1237009" ], "modifiers": [ [ "species_10592544", "catalyst" ] ], "additional_components": [ "Q8I0L6", "DDB_G0280059", "Q9NIV0", "DDB_G0283389" ] }, "reaction_10597320": { "compartment": "compartment_70101", "id": "reaction_10597320", "reactome": "R-DDI-1247649", "name": "AQP1 tetramer transports CO2 from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113528" ], "products": [ "species_1237009" ], "modifiers": [ [ "species_10592019", "catalyst" ] ], "additional_components": [ "Q9U8P7", "DDB_G0267378" ] }, "reaction_10608673": { "compartment": "compartment_7660", "id": "reaction_10608673", "reactome": "R-DDI-5687664", "name": "FEN1 cleaves displaced ssDNA flaps during MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10608663" ], "products": [ "species_10608670", "species_10577480", "species_68454" ], "modifiers": [ [ "species_10608663", "catalyst" ] ], "additional_components": [ "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54NU0", "DDB_G0284987", "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "DDB_G0284987", "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54NU0", "DDB_G0284987" ] }, "reaction_10608661": { "compartment": "compartment_7660", "id": "reaction_10608661", "reactome": "R-DDI-5687640", "name": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10608650" ], "products": [ "species_113541", "species_10608658" ], "modifiers": [ [ "species_10608650", "catalyst" ] ], "additional_components": [ "Q54S42", "DDB_G0282679", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54NU0", "DDB_G0284987", "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54S42", "DDB_G0282679", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q54NU0", "DDB_G0284987", "Q54S42", "DDB_G0282679", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54NU0", "DDB_G0284987" ] }, "reaction_10608677": { "compartment": "compartment_7660", "id": "reaction_10608677", "reactome": "R-DDI-5687673", "name": "MRN recruits LIG3:XRCC1 to MMEJ sites", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608670", "species_10580807" ], "products": [ "species_10608675" ], "modifiers": [], "additional_components": [ "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786" ] }, "reaction_10608666": { "compartment": "compartment_7660", "id": "reaction_10608666", "reactome": "R-DDI-5687653", "name": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427523", "species_10608658" ], "products": [ "species_427497", "species_10606279", "species_10608663", "species_10608644" ], "modifiers": [ [ "species_10608658", "catalyst" ] ], "additional_components": [ "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54S42", "DDB_G0282679", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q54NU0", "DDB_G0284987", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820", "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54NU0", "DDB_G0284987", "Q54S42", "DDB_G0282679", "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54S42", "DDB_G0282679", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q54NU0", "DDB_G0284987" ] }, "reaction_10608637": { "compartment": "compartment_7660", "id": "reaction_10608637", "reactome": "R-DDI-5687464", "name": "MRN and RBBP8 resect DNA DSBs in MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10608630" ], "products": [ "species_30555", "species_10608634" ], "modifiers": [ [ "species_10608630", "catalyst" ] ], "additional_components": [ "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786" ] }, "reaction_10608652": { "compartment": "compartment_7660", "id": "reaction_10608652", "reactome": "R-DDI-5687484", "name": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608634", "species_10577480", "species_10606233", "species_10608644" ], "products": [ "species_10608650" ], "modifiers": [], "additional_components": [ "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "DDB_G0284987", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q54S42", "DDB_G0282679", "Q54S42", "DDB_G0282679", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54NU0", "DDB_G0284987" ] }, "reaction_10608369": { "compartment": "compartment_7660", "id": "reaction_10608369", "reactome": "R-DDI-5685230", "name": "CHEK1 phosphorylates RAD51", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10608364" ], "products": [ "species_113582", "species_10608367" ], "modifiers": [ [ "species_10577605", "catalyst" ] ], "additional_components": [ "DDB_G0273139", "DDB_G0273139", "DDB_G0279719" ] }, "reaction_10608453": { "compartment": "compartment_7660", "id": "reaction_10608453", "reactome": "R-DDI-5685341", "name": "BCDX2 complex stabilizes RAD51 filament", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608435", "species_10608449" ], "products": [ "species_10608451" ], "modifiers": [], "additional_components": [ "Q54BU8", "DDB_G0293414", "Q557E6", "DDB_G0273139", "Q86IV6", "DDB_G0274777", "Q54Q57", "DDB_G0284153", "Q54DM3", "DDB_G0292130", "Q54GC4", "DDB_G0290275", "Q8T2T7", "DDB_G0275257", "Q54ED2", "DDB_G0291570", "Q54EK9", "DDB_G0291466", "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54LI7", "DDB_G0286621", "Q1ZXF0", "DDB_G0285287", "Q54PJ7", "DDB_G0284507", "Q54G98", "DDB_G0290297", "Q1ZXF0", "DDB_G0285287", "Q54PJ7", "DDB_G0284507", "Q54G98", "DDB_G0290297", "Q54BU8", "DDB_G0293414", "Q557E6", "DDB_G0273139", "Q86IV6", "DDB_G0274777", "Q54Q57", "DDB_G0284153", "Q54DM3", "DDB_G0292130", "Q54GC4", "DDB_G0290275", "Q8T2T7", "DDB_G0275257", "Q54ED2", "DDB_G0291570", "Q54EK9", "DDB_G0291466", "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54LI7", "DDB_G0286621" ] }, "reaction_10608379": { "compartment": "compartment_7660", "id": "reaction_10608379", "reactome": "R-DDI-5685242", "name": "CHEK1 phosphorylates BRCA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10608374" ], "products": [ "species_113582", "species_10608377" ], "modifiers": [ [ "species_10577605", "catalyst" ] ], "additional_components": [ "DDB_G0293414", "DDB_G0293414", "DDB_G0279719" ] }, "reaction_10608473": { "compartment": "compartment_7660", "id": "reaction_10608473", "reactome": "R-DDI-5685994", "name": "Long-range resection of DNA DSBs by EXO1 or DNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10608468" ], "products": [ "species_30555", "species_10608470" ], "modifiers": [ [ "species_10608468", "catalyst" ] ], "additional_components": [ "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54EK9", "DDB_G0291466", "Q86IV6", "DDB_G0274777", "Q54Q57", "DDB_G0284153", "Q54DM3", "DDB_G0292130", "Q54GC4", "DDB_G0290275", "Q8T2T7", "DDB_G0275257", "Q54ED2", "DDB_G0291570", "Q54LI7", "DDB_G0286621", "Q86IV6", "DDB_G0274777", "Q54Q57", "DDB_G0284153", "Q54DM3", "DDB_G0292130", "Q54GC4", "DDB_G0290275", "Q8T2T7", "DDB_G0275257", "Q54ED2", "DDB_G0291570", "Q54EK9", "DDB_G0291466", "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54LI7", "DDB_G0286621", "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54EK9", "DDB_G0291466", "Q86IV6", "DDB_G0274777", "Q54Q57", "DDB_G0284153", "Q54DM3", "DDB_G0292130", "Q54GC4", "DDB_G0290275", "Q8T2T7", "DDB_G0275257", "Q54ED2", "DDB_G0291570", "Q54LI7", "DDB_G0286621" ] }, "reaction_10581776": { "compartment": "compartment_7660", "id": "reaction_10581776", "reactome": "R-DDI-75998", "name": "Formation of RAD52 heptameric ring structure complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581772" ], "products": [ "species_10581774" ], "modifiers": [], "additional_components": [ "DDB_G0269406", "Q55E38", "DDB_G0269406" ] }, "reaction_10612584": { "compartment": "compartment_7660", "id": "reaction_10612584", "reactome": "R-DDI-6785594", "name": "FANCD2 binds FANCI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612575", "species_10612580" ], "products": [ "species_10612582" ], "modifiers": [], "additional_components": [ "DDB_G0268216", "DDB_G0293476", "Q54BR4", "DDB_G0293476", "Q55F81", "DDB_G0268216" ] }, "reaction_10582999": { "compartment": "compartment_70101", "id": "reaction_10582999", "reactome": "R-DDI-111925", "name": "cAMP induces dissociation of inactive PKA tetramers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582995" ], "products": [ "species_10582991", "species_10582997" ], "modifiers": [], "additional_components": [ "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029", "P05987", "DDB_G0279413", "Q8MM62", "DDB_G0276027", "species_30389", "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029", "species_30389", "P05987", "DDB_G0279413", "Q8MM62", "DDB_G0276027" ] }, "reaction_10611073": { "compartment": "compartment_70101", "id": "reaction_10611073", "reactome": "R-DDI-5690808", "name": "UCHL3, SENP8 cleave NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10611064" ], "products": [ "species_10611070", "species_10611068" ], "modifiers": [ [ "species_10611064", "catalyst" ] ], "additional_components": [ "Q54T48", "DDB_G0282007", "Q54XV3", "DDB_G0278711", "DDB_G0278711", "Q54T48", "DDB_G0282007", "Q54XV3", "DDB_G0278711", "Q54T48", "DDB_G0282007", "Q54XV3", "DDB_G0278711" ] }, "reaction_10623717": { "compartment": "compartment_70101", "id": "reaction_10623717", "reactome": "R-DDI-8952618", "name": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623697" ], "products": [ "species_10623709", "species_10623518" ], "modifiers": [ [ "species_10623697", "catalyst" ], [ "species_10623715", "inhibitor" ] ], "additional_components": [ "Q54XV3", "DDB_G0278711", "Q54TI6", "DDB_G0281725", "Q54GP1", "DDB_G0290025", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q54GP1", "DDB_G0290025", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54XV3", "DDB_G0278711", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "DDB_G0281725", "Q54XV3", "DDB_G0278711", "Q54TI6", "DDB_G0281725", "Q54GP1", "DDB_G0290025", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q54GP1", "DDB_G0290025", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813" ] }, "reaction_10624069": { "compartment": "compartment_7660", "id": "reaction_10624069", "reactome": "R-DDI-8956045", "name": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623818" ], "products": [ "species_10624064", "species_10624066" ], "modifiers": [ [ "species_10611193", "catalyst" ] ], "additional_components": [ "Q54MP2", "DDB_G0285813", "Q54DR0", "DDB_G0292074", "Q54XV3", "DDB_G0278711", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54E28", "DDB_G0291832", "Q551N8", "DDB_G0276481", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54IY4", "DDB_G0288453", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q55DE3", "DDB_G0269686", "Q54MH6", "DDB_G0285847", "Q552R1", "DDB_G0275925", "Q54K33", "DDB_G0287629", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54DR0", "DDB_G0292074", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54E28", "DDB_G0291832", "Q551N8", "DDB_G0276481", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54IY4", "DDB_G0288453", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q55DE3", "DDB_G0269686", "Q54MH6", "DDB_G0285847", "Q552R1", "DDB_G0275925", "Q54K33", "DDB_G0287629", "Q54PF3", "DDB_G0284597", "Q54QX3", "DDB_G0283587", "Q54HL6", "DDB_G0289361", "Q55BD5", "DDB_G0271282", "Q54E53", "DDB_G0291848", "Q54C92", "DDB_G0293180", "Q75K24", "DDB_G0275471", "Q54B82", "DDB_G0293844" ] }, "reaction_10623720": { "compartment": "compartment_70101", "id": "reaction_10623720", "reactome": "R-DDI-8952620", "name": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623695", "species_10623652", "species_10623542" ], "products": [ "species_10623697" ], "modifiers": [], "additional_components": [ "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54TI6", "DDB_G0281725", "Q54XV3", "DDB_G0278711", "Q54TI6", "DDB_G0281725", "Q54GP1", "DDB_G0290025", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813" ] }, "reaction_10623656": { "compartment": "compartment_70101", "id": "reaction_10623656", "reactome": "R-DDI-8952039", "name": "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623629", "species_10623576", "species_10623652" ], "products": [ "species_10623654" ], "modifiers": [], "additional_components": [ "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q9XZJ3", "DDB_G0267384", "O60999", "DDB_G0291972", "Q54XF7", "DDB_G0278991", "Q54J43", "DDB_G0288307", "Q54X83", "DDB_G0279139", "Q54Q05", "DDB_G0284201", "Q54K33", "DDB_G0287629", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "Q54XV3", "DDB_G0278711", "Q54GP1", "DDB_G0290025", "Q54GP1", "DDB_G0290025", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "Q54XV3", "DDB_G0278711", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q9XZJ3", "DDB_G0267384", "O60999", "DDB_G0291972", "Q54XF7", "DDB_G0278991", "Q54J43", "DDB_G0288307", "Q54X83", "DDB_G0279139", "Q54Q05", "DDB_G0284201", "Q54K33", "DDB_G0287629" ] }, "reaction_10623977": { "compartment": "compartment_70101", "id": "reaction_10623977", "reactome": "R-DDI-8955241", "name": "CAND1 binds cytosolic CRL E3 ubiquitin ligases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623973", "species_10611216" ], "products": [ "species_10623975" ], "modifiers": [], "additional_components": [ "O60999", "DDB_G0291972", "Q9XZJ3", "DDB_G0267384", "Q54XF7", "DDB_G0278991", "Q54PM1", "DDB_G0284461", "Q54Q05", "DDB_G0284201", "Q54K33", "DDB_G0287629", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54LV9", "DDB_G0286387", "Q55BF8", "DDB_G0271372", "Q54DL2", "DDB_G0292144", "Q54D84", "DDB_G0292436", "Q86AD8", "DDB_G0271500", "Q54XA6", "DDB_G0279093", "Q54NZ5", "DDB_G0284903", "Q54J43", "DDB_G0288307", "Q54X83", "DDB_G0279139", "DDB_G0274167", "Q86KD1", "DDB_G0274167", "O60999", "DDB_G0291972", "Q9XZJ3", "DDB_G0267384", "Q54XF7", "DDB_G0278991", "Q54PM1", "DDB_G0284461", "Q54Q05", "DDB_G0284201", "Q54K33", "DDB_G0287629", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54LV9", "DDB_G0286387", "Q55BF8", "DDB_G0271372", "Q54DL2", "DDB_G0292144", "Q54D84", "DDB_G0292436", "Q86AD8", "DDB_G0271500", "Q54XA6", "DDB_G0279093", "Q54NZ5", "DDB_G0284903", "Q54J43", "DDB_G0288307", "Q54X83", "DDB_G0279139" ] }, "reaction_10623983": { "compartment": "compartment_7660", "id": "reaction_10623983", "reactome": "R-DDI-8955245", "name": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623979", "species_10623754" ], "products": [ "species_10623981" ], "modifiers": [], "additional_components": [ "DDB_G0274167", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54E28", "DDB_G0291832", "Q551N8", "DDB_G0276481", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54IY4", "DDB_G0288453", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q55DE3", "DDB_G0269686", "Q54MH6", "DDB_G0285847", "Q552R1", "DDB_G0275925", "Q54K33", "DDB_G0287629", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54E28", "DDB_G0291832", "Q551N8", "DDB_G0276481", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54IY4", "DDB_G0288453", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q55DE3", "DDB_G0269686", "Q54MH6", "DDB_G0285847", "Q552R1", "DDB_G0275925", "Q54K33", "DDB_G0287629", "Q86KD1", "DDB_G0274167" ] }, "reaction_10623823": { "compartment": "compartment_7660", "id": "reaction_10623823", "reactome": "R-DDI-8952639", "name": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623726", "species_10623780", "species_10623792" ], "products": [ "species_10623794" ], "modifiers": [], "additional_components": [ "Q54XV3", "DDB_G0278711", "Q54TI6", "DDB_G0281725", "Q54MP2", "DDB_G0285813", "Q54DR0", "DDB_G0292074", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54E28", "DDB_G0291832", "Q551N8", "DDB_G0276481", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54IY4", "DDB_G0288453", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q55DE3", "DDB_G0269686", "Q54MH6", "DDB_G0285847", "Q552R1", "DDB_G0275925", "Q54K33", "DDB_G0287629", "Q54MP2", "DDB_G0285813", "Q54DR0", "DDB_G0292074", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54E28", "DDB_G0291832", "Q551N8", "DDB_G0276481", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54IY4", "DDB_G0288453", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q55DE3", "DDB_G0269686", "Q54MH6", "DDB_G0285847", "Q552R1", "DDB_G0275925", "Q54K33", "DDB_G0287629", "Q54XV3", "DDB_G0278711", "Q54TI6", "DDB_G0281725" ] }, "reaction_10623821": { "compartment": "compartment_7660", "id": "reaction_10623821", "reactome": "R-DDI-8952638", "name": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623794" ], "products": [ "species_10623818", "species_10623796" ], "modifiers": [ [ "species_10623794", "catalyst" ] ], "additional_components": [ "Q54MP2", "DDB_G0285813", "Q54DR0", "DDB_G0292074", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54E28", "DDB_G0291832", "Q551N8", "DDB_G0276481", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54IY4", "DDB_G0288453", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q55DE3", "DDB_G0269686", "Q54MH6", "DDB_G0285847", "Q552R1", "DDB_G0275925", "Q54K33", "DDB_G0287629", "Q54XV3", "DDB_G0278711", "Q54TI6", "DDB_G0281725", "Q54MP2", "DDB_G0285813", "Q54DR0", "DDB_G0292074", "Q54XV3", "DDB_G0278711", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54E28", "DDB_G0291832", "Q551N8", "DDB_G0276481", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54IY4", "DDB_G0288453", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q55DE3", "DDB_G0269686", "Q54MH6", "DDB_G0285847", "Q552R1", "DDB_G0275925", "Q54K33", "DDB_G0287629", "DDB_G0281725", "Q54MP2", "DDB_G0285813", "Q54DR0", "DDB_G0292074", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54E28", "DDB_G0291832", "Q551N8", "DDB_G0276481", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54IY4", "DDB_G0288453", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q55DE3", "DDB_G0269686", "Q54MH6", "DDB_G0285847", "Q552R1", "DDB_G0275925", "Q54K33", "DDB_G0287629", "Q54XV3", "DDB_G0278711", "Q54TI6", "DDB_G0281725" ] }, "reaction_10623985": { "compartment": "compartment_7660", "id": "reaction_10623985", "reactome": "R-DDI-8955285", "name": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623981", "species_10623778" ], "products": [ "species_10623979", "species_10623780" ], "modifiers": [], "additional_components": [ "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54E28", "DDB_G0291832", "Q551N8", "DDB_G0276481", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54IY4", "DDB_G0288453", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q55DE3", "DDB_G0269686", "Q54MH6", "DDB_G0285847", "Q552R1", "DDB_G0275925", "Q54K33", "DDB_G0287629", "Q86KD1", "DDB_G0274167", "Q54MP2", "DDB_G0285813", "Q54DR0", "DDB_G0292074", "DDB_G0274167", "Q54MP2", "DDB_G0285813", "Q54DR0", "DDB_G0292074", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54E28", "DDB_G0291832", "Q551N8", "DDB_G0276481", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54IY4", "DDB_G0288453", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q55DE3", "DDB_G0269686", "Q54MH6", "DDB_G0285847", "Q552R1", "DDB_G0275925", "Q54K33", "DDB_G0287629" ] }, "reaction_10624084": { "compartment": "compartment_70101", "id": "reaction_10624084", "reactome": "R-DDI-8956099", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624075", "species_10624080" ], "products": [ "species_10624082" ], "modifiers": [], "additional_components": [ "Q54K33", "DDB_G0287629", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q54Q05", "DDB_G0284201", "O60999", "DDB_G0291972", "Q54XF7", "DDB_G0278991", "Q9XZJ3", "DDB_G0267384", "Q54XV3", "DDB_G0278711", "DDB_G0270358", "Q55BU7", "DDB_G0270358", "Q54K33", "DDB_G0287629", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q54Q05", "DDB_G0284201", "O60999", "DDB_G0291972", "Q54XF7", "DDB_G0278991", "Q9XZJ3", "DDB_G0267384", "Q54XV3", "DDB_G0278711" ] }, "reaction_10624090": { "compartment": "compartment_876", "id": "reaction_10624090", "reactome": "R-DDI-8956200", "name": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623695", "species_10623713" ], "products": [ "species_10623715" ], "modifiers": [], "additional_components": [ "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "DDB_G0290025", "Q54GP1", "DDB_G0290025", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813" ] }, "reaction_10623515": { "compartment": "compartment_70101", "id": "reaction_10623515", "reactome": "R-DDI-8951644", "name": "Release of mature NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611068" ], "products": [ "species_10611066", "species_10610849" ], "modifiers": [], "additional_components": [ "Q54T48", "DDB_G0282007", "Q54XV3", "DDB_G0278711", "DDB_G0278711", "DDB_G0282007" ] }, "reaction_10623993": { "compartment": "compartment_70101", "id": "reaction_10623993", "reactome": "R-DDI-8955289", "name": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623627", "species_10623975" ], "products": [ "species_10623991", "species_10611216" ], "modifiers": [], "additional_components": [ "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q86KD1", "DDB_G0274167", "O60999", "DDB_G0291972", "Q9XZJ3", "DDB_G0267384", "Q54XF7", "DDB_G0278991", "Q54PM1", "DDB_G0284461", "Q54Q05", "DDB_G0284201", "Q54K33", "DDB_G0287629", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54LV9", "DDB_G0286387", "Q55BF8", "DDB_G0271372", "Q54DL2", "DDB_G0292144", "Q54D84", "DDB_G0292436", "Q86AD8", "DDB_G0271500", "Q54XA6", "DDB_G0279093", "Q54NZ5", "DDB_G0284903", "Q54J43", "DDB_G0288307", "Q54X83", "DDB_G0279139", "O60999", "DDB_G0291972", "Q9XZJ3", "DDB_G0267384", "Q54XF7", "DDB_G0278991", "Q54PM1", "DDB_G0284461", "Q54Q05", "DDB_G0284201", "Q54K33", "DDB_G0287629", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q54LV9", "DDB_G0286387", "Q55BF8", "DDB_G0271372", "Q54DL2", "DDB_G0292144", "Q54D84", "DDB_G0292436", "Q86AD8", "DDB_G0271500", "Q54XA6", "DDB_G0279093", "Q54NZ5", "DDB_G0284903", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54J43", "DDB_G0288307", "Q54X83", "DDB_G0279139", "DDB_G0274167" ] }, "reaction_10624062": { "compartment": "compartment_70101", "id": "reaction_10624062", "reactome": "R-DDI-8956040", "name": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624049" ], "products": [ "species_10611066", "species_10624059" ], "modifiers": [ [ "species_10619704", "catalyst" ] ], "additional_components": [ "Q54Q05", "DDB_G0284201", "Q54K33", "DDB_G0287629", "Q54PM1", "DDB_G0284461", "O60999", "DDB_G0291972", "Q54XF7", "DDB_G0278991", "Q9XZJ3", "DDB_G0267384", "Q54XV3", "DDB_G0278711", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q54LV9", "DDB_G0286387", "Q55BF8", "DDB_G0271372", "Q54DL2", "DDB_G0292144", "Q54D84", "DDB_G0292436", "Q86AD8", "DDB_G0271500", "Q54XA6", "DDB_G0279093", "Q54NZ5", "DDB_G0284903", "Q54GP1", "DDB_G0290025", "Q54J43", "DDB_G0288307", "Q54X83", "DDB_G0279139", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "DDB_G0278711", "Q54GP1", "DDB_G0290025", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q54LV9", "DDB_G0286387", "Q55BF8", "DDB_G0271372", "Q54DL2", "DDB_G0292144", "Q54D84", "DDB_G0292436", "Q86AD8", "DDB_G0271500", "Q54XA6", "DDB_G0279093", "Q54NZ5", "DDB_G0284903", "Q9XZJ3", "DDB_G0267384", "Q54XF7", "DDB_G0278991", "Q54PM1", "DDB_G0284461", "Q54Q05", "DDB_G0284201", "Q54J43", "DDB_G0288307", "Q54X83", "DDB_G0279139", "Q75K24", "DDB_G0275471", "Q54C92", "DDB_G0293180", "Q54QX3", "DDB_G0283587", "Q55BD5", "DDB_G0271282", "Q54E53", "DDB_G0291848", "Q54HL6", "DDB_G0289361", "Q54PF3", "DDB_G0284597", "Q54B82", "DDB_G0293844" ] }, "reaction_10623679": { "compartment": "compartment_70101", "id": "reaction_10623679", "reactome": "R-DDI-8952044", "name": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623654" ], "products": [ "species_10623676", "species_10623557" ], "modifiers": [ [ "species_10623654", "catalyst" ] ], "additional_components": [ "Q54GP1", "DDB_G0290025", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "Q54XV3", "DDB_G0278711", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q9XZJ3", "DDB_G0267384", "O60999", "DDB_G0291972", "Q54XF7", "DDB_G0278991", "Q54J43", "DDB_G0288307", "Q54X83", "DDB_G0279139", "Q54Q05", "DDB_G0284201", "Q54K33", "DDB_G0287629", "Q54GP1", "DDB_G0290025", "Q54J43", "DDB_G0288307", "Q54X83", "DDB_G0279139", "Q54Q05", "DDB_G0284201", "Q54K33", "DDB_G0287629", "Q54XF7", "DDB_G0278991", "Q9XZJ3", "DDB_G0267384", "O60999", "DDB_G0291972", "Q54XV3", "DDB_G0278711", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q94490", "DDB_G0284865", "Q54J12", "DDB_G0288697", "Q54IK3", "DDB_G0288697", "Q54GP1", "DDB_G0290025", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "Q54XV3", "DDB_G0278711", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q9XZJ3", "DDB_G0267384", "O60999", "DDB_G0291972", "Q54XF7", "DDB_G0278991", "Q54J43", "DDB_G0288307", "Q54X83", "DDB_G0279139", "Q54Q05", "DDB_G0284201", "Q54K33", "DDB_G0287629" ] }, "reaction_10585332": { "compartment": "compartment_70101", "id": "reaction_10585332", "reactome": "R-DDI-174070", "name": "Association of Cdh1 with the APC/C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577382", "species_10577377" ], "products": [ "species_10577384" ], "modifiers": [], "additional_components": [ "DDB_G0287259", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54KM3", "DDB_G0287259" ] }, "reaction_10585450": { "compartment": "compartment_70101", "id": "reaction_10585450", "reactome": "R-DDI-174224", "name": "Dissociation of Cdc20 from APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585386" ], "products": [ "species_10583643", "species_10577377" ], "modifiers": [], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54MZ3", "DDB_G0285601", "DDB_G0285601", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021" ] }, "reaction_10587270": { "compartment": "compartment_7660", "id": "reaction_10587270", "reactome": "R-DDI-199839", "name": "AKT can phosphorylate RSK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10587243" ], "products": [ "species_113582", "species_10587247" ], "modifiers": [ [ "species_10587267", "catalyst" ] ], "additional_components": [ "DDB_G0277449", "DDB_G0277449", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795" ] }, "reaction_10603208": { "compartment": "compartment_7660", "id": "reaction_10603208", "reactome": "R-DDI-3788705", "name": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10585338" ], "products": [ "species_113582", "species_10585340" ], "modifiers": [ [ "species_10585338", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "P34112", "DDB_G0272813", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "P34112", "DDB_G0272813", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259" ] }, "reaction_10603227": { "compartment": "compartment_7660", "id": "reaction_10603227", "reactome": "R-DDI-3788724", "name": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603218", "species_10576865" ], "products": [ "species_10603224" ], "modifiers": [ [ "species_10603218", "catalyst" ] ], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259" ] }, "reaction_10603210": { "compartment": "compartment_7660", "id": "reaction_10603210", "reactome": "R-DDI-3788708", "name": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585336", "species_10576705" ], "products": [ "species_10585338" ], "modifiers": [], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "P34112", "DDB_G0272813", "P34112", "DDB_G0272813", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259" ] }, "reaction_10598257": { "compartment": "compartment_70101", "id": "reaction_10598257", "reactome": "R-DDI-1483222", "name": "ETA is phosphorylated to PETA by CHK/ETNK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1498751" ], "products": [ "species_29370", "species_428686" ], "modifiers": [ [ "species_10598254", "catalyst" ] ], "additional_components": [ "Q554D8", "DDB_G0275265", "Q869T9", "DDB_G0274955" ] }, "reaction_10598075": { "compartment": "compartment_12045", "id": "reaction_10598075", "reactome": "R-DDI-1482962", "name": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500603", "species_1500596" ], "products": [ "species_1500581", "species_109395" ], "modifiers": [ [ "species_10598072", "catalyst" ] ], "additional_components": [ "Q8T2Q6", "DDB_G0275235", "Q54XM0", "DDB_G0278947", "Q550W1", "DDB_G0276763", "Q55AQ3", "DDB_G0271794", "species_29926", "species_266099" ] }, "reaction_10598234": { "compartment": "compartment_12045", "id": "reaction_10598234", "reactome": "R-DDI-1483203", "name": "PA is dephosphorylated to DAG by LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426755" ], "products": [ "species_29372", "species_1500596" ], "modifiers": [ [ "species_10598231", "catalyst" ] ], "additional_components": [ "Q75JA1", "DDB_G0271730", "species_29926" ] }, "reaction_10598223": { "compartment": "compartment_12045", "id": "reaction_10598223", "reactome": "R-DDI-1483190", "name": "PETA and CTP are condensed to CDP-ETA by PCY2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428686", "species_110614" ], "products": [ "species_111294", "species_1500603" ], "modifiers": [ [ "species_10598220", "catalyst" ] ], "additional_components": [ "Q55BZ4", "DDB_G0270298" ] }, "reaction_10583607": { "compartment": "compartment_70101", "id": "reaction_10583607", "reactome": "R-DDI-141186", "name": "MAOA:FAD oxidatively deaminates of 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_209914", "species_29368" ], "products": [ "species_500604", "species_29382", "species_29408" ], "modifiers": [ [ "species_10583604", "catalyst" ] ], "additional_components": [ "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10589900": { "compartment": "compartment_5460", "id": "reaction_10589900", "reactome": "R-DDI-380608", "name": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_380598" ], "products": [ "species_113529", "species_380593", "species_29362" ], "modifiers": [ [ "species_10578724", "catalyst" ] ], "additional_components": [ "Q54FY3", "DDB_G0290479" ] }, "reaction_10583105": { "compartment": "compartment_70101", "id": "reaction_10583105", "reactome": "R-DDI-112037", "name": "Inactivation of PLC beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10582955" ], "products": [ "species_10583103", "species_29372", "species_10582859" ], "modifiers": [], "additional_components": [ "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438", "Q02158", "DDB_G0292736", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29420", "DDB_G0292736" ] }, "reaction_10592511": { "compartment": "compartment_70101", "id": "reaction_10592511", "reactome": "R-DDI-442749", "name": "CaMKK autophosphorylates in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10592503" ], "products": [ "species_113582", "species_10592508" ], "modifiers": [ [ "species_10592503", "catalyst" ] ], "additional_components": [ "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "species_74112", "Q55CW1", "DDB_G0270680", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "species_74112", "Q55CW1", "DDB_G0270680", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "species_74112", "Q55CW1", "DDB_G0270680" ] }, "reaction_10583076": { "compartment": "compartment_70101", "id": "reaction_10583076", "reactome": "R-DDI-111955", "name": "cAMP hydrolysis by Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10583073", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121" ] }, "reaction_10583078": { "compartment": "compartment_70101", "id": "reaction_10583078", "reactome": "R-DDI-111956", "name": "Calmodulin activates Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583073" ], "products": [ "species_10583073" ], "modifiers": [ [ "species_10583042", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121", "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917" ] }, "reaction_10583044": { "compartment": "compartment_876", "id": "reaction_10583044", "reactome": "R-DDI-111930", "name": "Adenylate cyclase produces cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_111294", "species_30389" ], "modifiers": [ [ "species_10583022", "catalyst" ], [ "species_10583042", "catalyst" ] ], "additional_components": [ "species_29926", "Q03100", "DDB_G0281545", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917" ] }, "reaction_10623546": { "compartment": "compartment_70101", "id": "reaction_10623546", "reactome": "R-DDI-8951727", "name": "cAMP binds PKA tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10582993" ], "products": [ "species_10582995" ], "modifiers": [], "additional_components": [ "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029", "P05987", "DDB_G0279413", "Q8MM62", "DDB_G0276027", "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029", "P05987", "DDB_G0279413", "Q8MM62", "DDB_G0276027", "species_30389" ] }, "reaction_10582958": { "compartment": "compartment_70101", "id": "reaction_10582958", "reactome": "R-DDI-111879", "name": "PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10582955", "catalyst" ] ], "additional_components": [ "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438", "Q02158", "DDB_G0292736" ] }, "reaction_10577793": { "compartment": "compartment_70101", "id": "reaction_10577793", "reactome": "R-DDI-70486", "name": "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29728" ], "products": [ "species_29370", "species_29800" ], "modifiers": [ [ "species_10577790", "catalyst" ] ], "additional_components": [ "species_29926", "Q9GPM4", "DDB_G0287595" ] }, "reaction_10589604": { "compartment": "compartment_70101", "id": "reaction_10589604", "reactome": "R-DDI-372843", "name": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_113544" ], "products": [ "species_113548", "species_198498" ], "modifiers": [ [ "species_10589601", "catalyst" ] ], "additional_components": [ "DDB_G0284225" ] }, "reaction_10586982": { "compartment": "compartment_70101", "id": "reaction_10586982", "reactome": "R-DDI-198508", "name": "malate + NAD+ <=> oxaloacetate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198498", "species_29360" ], "products": [ "species_70106", "species_76213", "species_73473" ], "modifiers": [ [ "species_10586979", "catalyst" ] ], "additional_components": [ "Q54GE6", "DDB_G0290207" ] }, "reaction_10577773": { "compartment": "compartment_70101", "id": "reaction_10577773", "reactome": "R-DDI-70479", "name": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30014", "species_29356" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10577770", "catalyst" ], [ "species_76577", "inhibitor" ] ], "additional_components": [ "Q6RYT0", "DDB_G0270836", "species_29926" ] }, "reaction_10589548": { "compartment": "compartment_70101", "id": "reaction_10589548", "reactome": "R-DDI-372448", "name": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_113553" ], "products": [ "species_29448", "species_113552" ], "modifiers": [ [ "species_10589543", "catalyst" ] ], "additional_components": [ "DDB_G0283329" ] }, "reaction_10589775": { "compartment": "compartment_70101", "id": "reaction_10589775", "reactome": "R-DDI-376851", "name": "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_198498" ], "products": [ "species_29406", "species_113544" ], "modifiers": [ [ "species_10586969", "catalyst" ] ], "additional_components": [ "Q54PY7", "DDB_G0284225" ] }, "reaction_10577775": { "compartment": "compartment_70101", "id": "reaction_10577775", "reactome": "R-DDI-70481", "name": "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29578" ], "products": [ "species_75970" ], "modifiers": [ [ "species_10577742", "catalyst" ] ], "additional_components": [ "Q869R8", "DDB_G0274471" ] }, "reaction_10577777": { "compartment": "compartment_70101", "id": "reaction_10577777", "reactome": "R-DDI-70482", "name": "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29800", "species_73473" ], "products": [ "species_29372", "species_29578", "species_29360" ], "modifiers": [ [ "species_10577732", "catalyst" ] ], "additional_components": [ "Q94469", "DDB_G0275153" ] }, "reaction_10578553": { "compartment": "compartment_70101", "id": "reaction_10578553", "reactome": "R-DDI-71445", "name": "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30485" ], "products": [ "species_29728" ], "modifiers": [ [ "species_10578550", "catalyst" ] ], "additional_components": [ "Q54NE6", "DDB_G0285311" ] }, "reaction_10577757": { "compartment": "compartment_70101", "id": "reaction_10577757", "reactome": "R-DDI-70475", "name": "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10577752", "catalyst" ] ], "additional_components": [ "Q5V9E9", "DDB_G0283673" ] }, "reaction_10586972": { "compartment": "compartment_70101", "id": "reaction_10586972", "reactome": "R-DDI-198440", "name": "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_113544" ], "products": [ "species_113594", "species_198498" ], "modifiers": [ [ "species_10586969", "catalyst" ] ], "additional_components": [ "Q54PY7", "DDB_G0284225" ] }, "reaction_10577628": { "compartment": "compartment_70101", "id": "reaction_10577628", "reactome": "R-DDI-70241", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_76213" ], "products": [ "species_29420", "species_113528", "species_29492" ], "modifiers": [ [ "species_10577625", "catalyst" ] ], "additional_components": [ "DDB_G0271904" ] }, "reaction_10577820": { "compartment": "compartment_70101", "id": "reaction_10577820", "reactome": "R-DDI-70494", "name": "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29492" ], "products": [ "species_30485" ], "modifiers": [ [ "species_10577817", "catalyst" ] ], "additional_components": [ "Q54RK5", "DDB_G0283137", "Q55F83", "DDB_G0268214", "species_29926" ] }, "reaction_10578556": { "compartment": "compartment_70101", "id": "reaction_10578556", "reactome": "R-DDI-71495", "name": "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29578", "species_75970" ], "products": [ "species_30014" ], "modifiers": [ [ "species_10577690", "catalyst" ] ], "additional_components": [ "Q86A67", "DDB_G0274375" ] }, "reaction_10589599": { "compartment": "compartment_5460", "id": "reaction_10589599", "reactome": "R-DDI-372819", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113573", "species_113587" ], "products": [ "species_372364", "species_113525", "species_29376" ], "modifiers": [ [ "species_10589596", "catalyst" ] ], "additional_components": [ "DDB_G0271904" ] }, "reaction_10577886": { "compartment": "compartment_5460", "id": "reaction_10577886", "reactome": "R-DDI-70613", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113587", "species_113552" ], "products": [ "species_113594", "species_113553" ], "modifiers": [ [ "species_10577869", "catalyst" ] ], "additional_components": [ "Q55F21", "DDB_G0268664" ] }, "reaction_10602325": { "compartment": "compartment_70101", "id": "reaction_10602325", "reactome": "R-DDI-3249379", "name": "p-S407-STAT6 is phosphorylated at Tyr641", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10602323" ], "products": [ "species_29370", "species_10602295" ], "modifiers": [], "additional_components": [ "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10602311": { "compartment": "compartment_70101", "id": "reaction_10602311", "reactome": "R-DDI-3249370", "name": "p-S407,Y641-STAT6 dimer migrates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602297" ], "products": [ "species_10602309" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638" ] }, "reaction_10602313": { "compartment": "compartment_70101", "id": "reaction_10602313", "reactome": "R-DDI-3249372", "name": "p-S407,Y641-STAT6 is dimerized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602295" ], "products": [ "species_10602297" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10597394": { "compartment": "compartment_876", "id": "reaction_10597394", "reactome": "R-DDI-1296348", "name": "Activation of TWIK-related K+ channel (TREK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10597391", "catalyst" ] ], "additional_components": [ "Q86K40", "DDB_G0277255", "Q8T268", "DDB_G0277255" ] }, "reaction_10598007": { "compartment": "compartment_12045", "id": "reaction_10598007", "reactome": "R-DDI-1482816", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[6]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10598004", "catalyst" ] ], "additional_components": [ "DDB_G0283551" ] }, "reaction_10597944": { "compartment": "compartment_12045", "id": "reaction_10597944", "reactome": "R-DDI-1482547", "name": "1-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524028", "species_1500578" ], "products": [ "species_426925", "species_76194" ], "modifiers": [ [ "species_10597927", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541", "Q54X10", "DDB_G0279277" ] }, "reaction_10597930": { "compartment": "compartment_12045", "id": "reaction_10597930", "reactome": "R-DDI-1482533", "name": "2-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_975614" ], "products": [ "species_426925", "species_76194" ], "modifiers": [ [ "species_10597927", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541", "Q54X10", "DDB_G0279277" ] }, "reaction_10621983": { "compartment": "compartment_12045", "id": "reaction_10621983", "reactome": "R-DDI-8874435", "name": "THEM86B hydrolyses PMCHO, PMETAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8874447" ], "products": [ "species_8874450", "species_5696116" ], "modifiers": [ [ "species_10621980", "catalyst" ] ], "additional_components": [ "CHEBI:17810", "CHEBI:17476", "CHEBI:36313", "CHEBI:36314", "DDB_G0275665" ] }, "reaction_10598014": { "compartment": "compartment_12045", "id": "reaction_10598014", "reactome": "R-DDI-1482856", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[5]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10597959", "catalyst" ] ], "additional_components": [ "DDB_G0284449" ] }, "reaction_10582832": { "compartment": "compartment_7660", "id": "reaction_10582832", "reactome": "R-DDI-111437", "name": "Cleavage of the 3'-end of the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582828" ], "products": [ "species_10582830", "species_10582465" ], "modifiers": [], "additional_components": [ "Q55A45", "DDB_G0272320", "C7G054", "DDB_G0302414", "Q86L45", "DDB_G0273003", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q54RX0", "DDB_G0282863", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q55A45", "DDB_G0272320", "C7G054", "DDB_G0302414", "Q86L45", "DDB_G0273003", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q54RX0", "DDB_G0282863" ] }, "reaction_10582834": { "compartment": "compartment_7660", "id": "reaction_10582834", "reactome": "R-DDI-111438", "name": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582432", "species_10582465" ], "products": [ "species_10582828" ], "modifiers": [], "additional_components": [ "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q55A45", "DDB_G0272320", "C7G054", "DDB_G0302414", "Q86L45", "DDB_G0273003", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "C7G054", "DDB_G0302414", "Q86L45", "DDB_G0273003", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q54RX0", "DDB_G0282863", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197" ] }, "reaction_10627229": { "compartment": "compartment_7660", "id": "reaction_10627229", "reactome": "R-DDI-9671145", "name": "DKC1 binds SHQ1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627225", "species_10584005" ], "products": [ "species_10627227" ], "modifiers": [], "additional_components": [ "DDB_G0269304", "DDB_G0281933", "Q54T81", "DDB_G0281933", "Q55EC4", "DDB_G0269304" ] }, "reaction_10600850": { "compartment": "compartment_7660", "id": "reaction_10600850", "reactome": "R-DDI-2294580", "name": "PLK1 hyperphosphorylates Condensin II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10600834" ], "products": [ "species_113582", "species_10600847" ], "modifiers": [ [ "species_10600834", "catalyst" ] ], "additional_components": [ "Q86HN7", "DDB_G0274503", "Q76NW2", "DDB_G0276863", "Q54PK4", "DDB_G0284499", "Q54ID6", "DDB_G0288819", "Q54DZ9", "DDB_G0291894", "Q54LV0", "DDB_G0286403", "Q54XY3", "DDB_G0278701", "Q86HN7", "DDB_G0274503", "Q76NW2", "DDB_G0276863", "Q54PK4", "DDB_G0284499", "Q54XY3", "DDB_G0278701", "Q54ID6", "DDB_G0288819", "Q54DZ9", "DDB_G0291894", "Q54LV0", "DDB_G0286403", "Q86HN7", "DDB_G0274503", "Q76NW2", "DDB_G0276863", "Q54PK4", "DDB_G0284499", "Q54ID6", "DDB_G0288819", "Q54DZ9", "DDB_G0291894", "Q54LV0", "DDB_G0286403", "Q54XY3", "DDB_G0278701" ] }, "reaction_10600854": { "compartment": "compartment_7660", "id": "reaction_10600854", "reactome": "R-DDI-2294590", "name": "PLK1 binds phosphorylated condensin II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600852", "species_10583697" ], "products": [ "species_10600834" ], "modifiers": [], "additional_components": [ "Q54PK4", "DDB_G0284499", "Q54ID6", "DDB_G0288819", "Q54DZ9", "DDB_G0291894", "Q54LV0", "DDB_G0286403", "Q54XY3", "DDB_G0278701", "Q76NW2", "DDB_G0276863", "DDB_G0274503", "Q86HN7", "DDB_G0274503", "Q76NW2", "DDB_G0276863", "Q54PK4", "DDB_G0284499", "Q54ID6", "DDB_G0288819", "Q54DZ9", "DDB_G0291894", "Q54LV0", "DDB_G0286403", "Q54XY3", "DDB_G0278701" ] }, "reaction_10600826": { "compartment": "compartment_7660", "id": "reaction_10600826", "reactome": "R-DDI-2288097", "name": "Condensin II complex binds H4K20me1-containing nucleosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600587", "species_10600624" ], "products": [ "species_10600824" ], "modifiers": [ [ "species_10600589", "catalyst" ] ], "additional_components": [ "Q54PK4", "DDB_G0284499", "Q54ID6", "DDB_G0288819", "Q54DZ9", "DDB_G0291894", "Q54LV0", "DDB_G0286403", "Q54XY3", "DDB_G0278701", "Q76NW2", "DDB_G0276863", "Q76NW2", "DDB_G0276863", "Q54PK4", "DDB_G0284499", "Q54ID6", "DDB_G0288819", "Q54DZ9", "DDB_G0291894", "Q54LV0", "DDB_G0286403", "Q54XY3", "DDB_G0278701", "Q54FX2", "DDB_G0290551", "Q54PK4", "DDB_G0284499", "Q54ID6", "DDB_G0288819", "Q54DZ9", "DDB_G0291894", "Q54LV0", "DDB_G0286403", "Q54XY3", "DDB_G0278701" ] }, "reaction_10600637": { "compartment": "compartment_7660", "id": "reaction_10600637", "reactome": "R-DDI-2172678", "name": "PHF8 demethylates histone H4K20me1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600630", "species_113671", "species_113685" ], "products": [ "species_10600634", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10600630", "catalyst" ] ], "additional_components": [ "Q76NW2", "DDB_G0276863", "species_71067", "species_71067", "Q76NW2", "DDB_G0276863", "Q76NW2", "DDB_G0276863", "species_71067" ] }, "reaction_10600591": { "compartment": "compartment_7660", "id": "reaction_10600591", "reactome": "R-DDI-2172666", "name": "RB1 binds condensin II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577547", "species_10600587" ], "products": [ "species_10600589" ], "modifiers": [], "additional_components": [ "DDB_G0290551", "Q54PK4", "DDB_G0284499", "Q54ID6", "DDB_G0288819", "Q54DZ9", "DDB_G0291894", "Q54LV0", "DDB_G0286403", "Q54XY3", "DDB_G0278701", "Q54FX2", "DDB_G0290551", "Q54PK4", "DDB_G0284499", "Q54ID6", "DDB_G0288819", "Q54DZ9", "DDB_G0291894", "Q54LV0", "DDB_G0286403", "Q54XY3", "DDB_G0278701" ] }, "reaction_10595203": { "compartment": "compartment_70101", "id": "reaction_10595203", "reactome": "R-DDI-939265", "name": "Activation of Rap1 by membrane-associated GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10589459" ], "products": [ "species_29420", "species_10589457" ], "modifiers": [ [ "species_10590642", "catalyst" ] ], "additional_components": [ "species_29420", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "species_29438", "Q54TK8", "DDB_G0281573", "Q8IS12", "DDB_G0275703" ] }, "reaction_10589538": { "compartment": "compartment_70101", "id": "reaction_10589538", "reactome": "R-DDI-354173", "name": "Activation of Rap1 by cytosolic GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10589459" ], "products": [ "species_29420", "species_10589457" ], "modifiers": [ [ "species_10589535", "catalyst" ] ], "additional_components": [ "species_29420", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "species_29438", "species_74112", "species_6797635", "Q55FD8", "DDB_G0268578", "Q55GH9", "DDB_G0267666", "Q8IS11", "DDB_G0290267", "Q8IS14", "DDB_G0277913", "Q8IS15", "DDB_G0277915", "Q8IS16", "DDB_G0276963", "Q8IS20", "DDB_G0282381", "Q8IS21", "DDB_G0269222", "Q8SSQ0", "DDB_G0274605", "Q8SSW7", "DDB_G0271868", "B0M0P8", "DDB_G0276371", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q54FF3", "DDB_G0290901", "Q54H95", "DDB_G0289613", "Q54PQ4", "DDB_G0284329", "Q54XL4", "DDB_G0289613" ] }, "reaction_10600085": { "compartment": "compartment_12045", "id": "reaction_10600085", "reactome": "R-DDI-2046093", "name": "Translocation of tetracosapentaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046050", "species_211579" ], "products": [ "species_5228339", "species_2046055", "species_211606" ], "modifiers": [ [ "species_10590195", "catalyst" ] ], "additional_components": [ "DDB_G0293194" ] }, "reaction_10600087": { "compartment": "compartment_17957", "id": "reaction_10600087", "reactome": "R-DDI-2046094", "name": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046042", "species_113601" ], "products": [ "species_113519", "species_113564", "species_162743", "species_159751", "species_2046045" ], "modifiers": [ [ "species_10593966", "catalyst" ] ], "additional_components": [ "Q55BY4", "DDB_G0271066", "C7FZW5", "DDB_G0271066" ] }, "reaction_10600071": { "compartment": "compartment_12045", "id": "reaction_10600071", "reactome": "R-DDI-2046083", "name": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046053", "species_113601" ], "products": [ "species_113519", "species_162743", "species_159751", "species_2046060" ], "modifiers": [ [ "species_10593964", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10600089": { "compartment": "compartment_17957", "id": "reaction_10600089", "reactome": "R-DDI-2046095", "name": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046060", "species_113601" ], "products": [ "species_2046048", "species_113519", "species_162743", "species_159751" ], "modifiers": [ [ "species_10593964", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10600091": { "compartment": "compartment_12045", "id": "reaction_10600091", "reactome": "R-DDI-2046098", "name": "Activation of linoleic acid to linoleoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211579", "species_162743", "species_2046044" ], "products": [ "species_2046064", "species_2046049", "species_2046063" ], "modifiers": [ [ "species_10600073", "catalyst" ] ], "additional_components": [ "species_29926", "Q54JK0", "DDB_G0288001", "Q55DR6", "DDB_G0269242", "Q1ZXQ4", "DDB_G0269474" ] }, "reaction_10599749": { "compartment": "compartment_20699", "id": "reaction_10599749", "reactome": "R-DDI-2022887", "name": "NDST1-4 N-deacetylates GlcNAc residues in heparan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2022884", "species_10599746" ], "products": [ "species_10599718", "species_2022890" ], "modifiers": [ [ "species_10599730", "catalyst" ] ], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488", "DDB_G0267630" ] }, "reaction_10599739": { "compartment": "compartment_20699", "id": "reaction_10599739", "reactome": "R-DDI-2022860", "name": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10599718" ], "products": [ "species_10599725", "species_742343" ], "modifiers": [ [ "species_10599730", "catalyst" ] ], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488", "DDB_G0267630" ] }, "reaction_10600141": { "compartment": "compartment_20699", "id": "reaction_10600141", "reactome": "R-DDI-2076611", "name": "HS3STs sulfate GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10599765" ], "products": [ "species_10599772", "species_742343" ], "modifiers": [ [ "species_10600128", "catalyst" ] ], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488", "DDB_G0267630" ] }, "reaction_10599821": { "compartment": "compartment_17963", "id": "reaction_10599821", "reactome": "R-DDI-2024108", "name": "Some HSPGs are secreted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599787" ], "products": [ "species_10599819" ], "modifiers": [], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488" ] }, "reaction_10600126": { "compartment": "compartment_17963", "id": "reaction_10600126", "reactome": "R-DDI-2076383", "name": "HS3ST1 sulfates GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10599765" ], "products": [ "species_10599772", "species_742343" ], "modifiers": [ [ "species_10600121", "catalyst" ] ], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488", "DDB_G0267630" ] }, "reaction_10599661": { "compartment": "compartment_20699", "id": "reaction_10599661", "reactome": "R-DDI-1878002", "name": "XYLTs transfer Xyl to core protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599635", "species_742361" ], "products": [ "species_10599642", "species_205687" ], "modifiers": [ [ "species_10599658", "catalyst" ] ], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488", "Q55F91", "DDB_G0269558", "Q55DR5", "DDB_G0269558" ] }, "reaction_10600145": { "compartment": "compartment_161320", "id": "reaction_10600145", "reactome": "R-DDI-2090038", "name": "NAGLU hydrolyses heparan chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090053" ], "products": [ "species_1678743", "species_2065212" ], "modifiers": [ [ "species_10599153", "catalyst" ] ], "additional_components": [ "DDB_G0291998" ] }, "reaction_10600147": { "compartment": "compartment_161320", "id": "reaction_10600147", "reactome": "R-DDI-2090079", "name": "GLB1 hydrolyses linker chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090075" ], "products": [ "species_1605637", "species_2090063" ], "modifiers": [ [ "species_10598338", "catalyst" ] ], "additional_components": [ "DDB_G0290217" ] }, "reaction_10600149": { "compartment": "compartment_17938", "id": "reaction_10600149", "reactome": "R-DDI-2090085", "name": "HGSNAT oligomer acetylates Heparan chain(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183", "species_2090045" ], "products": [ "species_2090053", "species_76194" ], "modifiers": [ [ "species_10599125", "catalyst" ] ], "additional_components": [ "Q54LX9", "DDB_G0286315" ] }, "reaction_10599156": { "compartment": "compartment_161320", "id": "reaction_10599156", "reactome": "R-DDI-1678742", "name": "NAGLU hydrolyses Heparan sulfate chain(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090069" ], "products": [ "species_2090080", "species_1678743" ], "modifiers": [ [ "species_10599153", "catalyst" ] ], "additional_components": [ "DDB_G0291998" ] }, "reaction_10599751": { "compartment": "compartment_876", "id": "reaction_10599751", "reactome": "R-DDI-2024084", "name": "HS-GAGs translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599134" ], "products": [ "species_10598515" ], "modifiers": [], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488" ] }, "reaction_10599128": { "compartment": "compartment_17938", "id": "reaction_10599128", "reactome": "R-DDI-1678660", "name": "HGSNAT oligomer acetylates Heparan sulfate chain(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2090040", "species_76183" ], "products": [ "species_2090069", "species_76194" ], "modifiers": [ [ "species_10599125", "catalyst" ] ], "additional_components": [ "Q54LX9", "DDB_G0286315" ] }, "reaction_10599148": { "compartment": "compartment_161320", "id": "reaction_10599148", "reactome": "R-DDI-1678716", "name": "IDUA hydrolyses Heparan sulfate chain(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2090033", "species_1605715" ], "products": [ "species_2090072", "species_1678617" ], "modifiers": [ [ "species_10599145", "catalyst" ] ], "additional_components": [ "DDB_G0288289" ] }, "reaction_10600143": { "compartment": "compartment_161320", "id": "reaction_10600143", "reactome": "R-DDI-2090037", "name": "IDUA hydrolyses Heparan sulfate chain(6)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090055" ], "products": [ "species_2090070", "species_1678617" ], "modifiers": [ [ "species_10599145", "catalyst" ] ], "additional_components": [ "DDB_G0288289" ] }, "reaction_10593201": { "compartment": "compartment_70101", "id": "reaction_10593201", "reactome": "R-DDI-450358", "name": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037" ], "products": [ "species_10584754" ], "modifiers": [ [ "species_10593152", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54C11", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "P11467", "DDB_G0290961", "Q86L54", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q54LU8", "DDB_G0286465" ] }, "reaction_10617650": { "compartment": "compartment_12045", "id": "reaction_10617650", "reactome": "R-DDI-6811425", "name": "NSF and SNAPs bind cis-SNARE at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611694", "species_10611703", "species_10617648" ], "products": [ "species_10617536" ], "modifiers": [], "additional_components": [ "Q75JI3", "DDB_G0276153", "Q54NP6", "DDB_G0285111", "Q55CR0", "DDB_G0269942", "Q55GJ4", "DDB_G0267646", "Q54TZ2", "DDB_G0281429", "Q54LH0", "DDB_G0286811", "Q55CR0", "DDB_G0269942", "Q54NP6", "DDB_G0285111", "Q55GJ4", "DDB_G0267646", "Q54TZ2", "DDB_G0281429", "Q54LH0", "DDB_G0286811", "Q75JI3", "DDB_G0276153" ] }, "reaction_10617491": { "compartment": "compartment_20699", "id": "reaction_10617491", "reactome": "R-DDI-6811415", "name": "RAB:GTP recruits GBF1 to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617199", "species_10616771" ], "products": [ "species_10617489" ], "modifiers": [], "additional_components": [ "species_29438", "Q552K3", "DDB_G0275969", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "Q558I0", "DDB_G0272905", "P34141", "DDB_G0291233", "P34140", "DDB_G0277867", "Q54EW9", "DDB_G0291293", "P34143", "DDB_G0271736", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "species_29438", "Q552K3", "DDB_G0275969", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "Q558I0", "DDB_G0272905", "P34141", "DDB_G0291233", "P34140", "DDB_G0277867", "Q54EW9", "DDB_G0291293", "P34143", "DDB_G0271736" ] }, "reaction_10617507": { "compartment": "compartment_20699", "id": "reaction_10617507", "reactome": "R-DDI-6811417", "name": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617503", "species_10616863", "species_10617497", "species_10617495", "species_10617233" ], "products": [ "species_10617505" ], "modifiers": [], "additional_components": [ "Q86JE5", "DDB_G0272124", "Q769F9", "DDB_G0288053", "Q54BN0", "DDB_G0293540", "Q556J9", "DDB_G0272889", "Q769F6", "DDB_G0277923", "Q769F7", "DDB_G0278969", "Q54DK9", "DDB_G0292148", "Q54TP9", "DDB_G0292148", "DDB_G0269942", "species_29438", "Q54X30", "DDB_G0290771", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q552K3", "DDB_G0275969", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "Q558I0", "DDB_G0272905", "P34141", "DDB_G0291233", "P34140", "DDB_G0277867", "Q54EW9", "DDB_G0291293", "P34143", "DDB_G0271736", "Q55EZ6", "DDB_G0268702", "Q23924", "DDB_G0284735", "Q54HL0", "DDB_G0289371", "Q54CA7", "DDB_G0293086", "Q54HD4", "DDB_G0289523", "Q54YD8", "DDB_G0278285", "Q55FU2", "DDB_G0267950", "Q55FR9", "DDB_G0267982", "Q769F9", "DDB_G0288053", "Q54BN0", "DDB_G0293540", "Q769F6", "DDB_G0277923", "Q769F7", "DDB_G0278969", "Q769F9", "DDB_G0288053", "Q54BN0", "DDB_G0293540", "Q769F6", "DDB_G0277923", "Q769F7", "DDB_G0278969", "species_29438", "Q54X30", "DDB_G0290771", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q552K3", "DDB_G0275969", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "Q558I0", "DDB_G0272905", "P34141", "DDB_G0291233", "P34140", "DDB_G0277867", "Q54EW9", "DDB_G0291293", "P34143", "DDB_G0271736", "Q55EZ6", "DDB_G0268702", "Q23924", "DDB_G0284735", "Q54HL0", "DDB_G0289371", "Q54CA7", "DDB_G0293086", "Q54HD4", "DDB_G0289523", "Q54YD8", "DDB_G0278285", "Q55FU2", "DDB_G0267950", "Q55FR9", "DDB_G0267982", "Q55CR0", "DDB_G0269942", "Q54DK9", "DDB_G0292148", "Q54TP9", "DDB_G0292148", "Q86JE5", "DDB_G0272124", "Q556J9", "DDB_G0272889" ] }, "reaction_10617539": { "compartment": "compartment_12045", "id": "reaction_10617539", "reactome": "R-DDI-6811422", "name": "NSF ATPase activity dissociates cis-SNARE at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10617536" ], "products": [ "species_10611694", "species_10617532", "species_29372", "species_10611703", "species_10617527", "species_10587872", "species_10617522" ], "modifiers": [ [ "species_10617536", "catalyst" ] ], "additional_components": [ "Q55CR0", "DDB_G0269942", "Q54NP6", "DDB_G0285111", "Q55GJ4", "DDB_G0267646", "Q54TZ2", "DDB_G0281429", "Q54LH0", "DDB_G0286811", "Q75JI3", "DDB_G0276153", "Q75JI3", "DDB_G0276153", "DDB_G0286811", "Q54NP6", "DDB_G0285111", "DDB_G0281429", "DDB_G0269942", "DDB_G0267646", "Q55CR0", "DDB_G0269942", "Q54NP6", "DDB_G0285111", "Q55GJ4", "DDB_G0267646", "Q54TZ2", "DDB_G0281429", "Q54LH0", "DDB_G0286811", "Q75JI3", "DDB_G0276153" ] }, "reaction_10617652": { "compartment": "compartment_12045", "id": "reaction_10617652", "reactome": "R-DDI-6811427", "name": "COPI vesicle uncoating at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617646" ], "products": [ "species_10617644", "species_10616843", "species_10617604", "species_10617648", "species_10611571" ], "modifiers": [], "additional_components": [ "Q54EW9", "DDB_G0291293", "P34143", "DDB_G0271736", "Q552K3", "DDB_G0275969", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "Q558I0", "DDB_G0272905", "P34141", "DDB_G0291233", "P34140", "DDB_G0277867", "species_29438", "Q55FR9", "DDB_G0267982", "Q55FU2", "DDB_G0267950", "Q54YD8", "DDB_G0278285", "Q54CA7", "DDB_G0293086", "Q54HD4", "DDB_G0289523", "Q54HL0", "DDB_G0289371", "Q23924", "DDB_G0284735", "Q55EZ6", "DDB_G0268702", "Q55CR0", "DDB_G0269942", "Q769F7", "DDB_G0278969", "Q54BN0", "DDB_G0293540", "Q769F9", "DDB_G0288053", "Q769F6", "DDB_G0277923", "Q55CJ0", "DDB_G0270040", "Q55CA1", "DDB_G0270150", "Q54YZ1", "DDB_G0277997", "Q55GJ4", "DDB_G0267646", "Q54TZ2", "DDB_G0281429", "Q54LH0", "DDB_G0286811", "Q86JE5", "DDB_G0272124", "Q556J9", "DDB_G0272889", "Q86JE5", "DDB_G0272124", "Q769F7", "DDB_G0278969", "Q54BN0", "DDB_G0293540", "Q769F9", "DDB_G0288053", "Q769F6", "DDB_G0277923", "Q556J9", "DDB_G0272889", "Q55EZ6", "DDB_G0268702", "Q23924", "DDB_G0284735", "Q54HL0", "DDB_G0289371", "Q54CA7", "DDB_G0293086", "Q54HD4", "DDB_G0289523", "Q54YD8", "DDB_G0278285", "Q55FU2", "DDB_G0267950", "Q55FR9", "DDB_G0267982", "Q769F7", "DDB_G0278969", "Q54BN0", "DDB_G0293540", "Q769F9", "DDB_G0288053", "Q769F6", "DDB_G0277923", "Q55CR0", "DDB_G0269942", "Q55GJ4", "DDB_G0267646", "Q54TZ2", "DDB_G0281429", "Q54LH0", "DDB_G0286811", "P34139", "DDB_G0283757", "species_29420" ] }, "reaction_10618658": { "compartment": "compartment_12045", "id": "reaction_10618658", "reactome": "R-DDI-8850041", "name": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10618647" ], "products": [ "species_10618655", "species_29420" ], "modifiers": [ [ "species_10618647", "catalyst" ] ], "additional_components": [ "Q54UJ4", "DDB_G0281043", "Q54DM6", "DDB_G0292124", "Q54GY8", "DDB_G0289827", "species_29420", "Q54UJ4", "DDB_G0281043", "Q54DM6", "DDB_G0292124", "Q54GY8", "DDB_G0289827", "species_29438", "Q54UJ4", "DDB_G0281043", "Q54DM6", "DDB_G0292124", "Q54GY8", "DDB_G0289827", "species_29420" ] }, "reaction_10618649": { "compartment": "compartment_12045", "id": "reaction_10618649", "reactome": "R-DDI-8850040", "name": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618633", "species_10618645" ], "products": [ "species_10618647" ], "modifiers": [], "additional_components": [ "Q54GY8", "DDB_G0289827", "species_29420", "Q54UJ4", "DDB_G0281043", "Q54DM6", "DDB_G0292124", "Q54UJ4", "DDB_G0281043", "Q54DM6", "DDB_G0292124", "Q54GY8", "DDB_G0289827", "species_29420" ] }, "reaction_10618509": { "compartment": "compartment_20699", "id": "reaction_10618509", "reactome": "R-DDI-8849345", "name": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_548819", "species_8848483" ], "products": [ "species_429785", "species_76194" ], "modifiers": [ [ "species_10618506", "catalyst" ] ], "additional_components": [ "DDB_G0288863" ] }, "reaction_10589211": { "compartment": "compartment_70101", "id": "reaction_10589211", "reactome": "R-DDI-350598", "name": "Arginine<=>Agmatine+CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468" ], "products": [ "species_113528", "species_351164" ], "modifiers": [ [ "species_10589208", "catalyst" ] ], "additional_components": [ "DDB_G0281109" ] }, "reaction_10590640": { "compartment": "compartment_17940", "id": "reaction_10590640", "reactome": "R-DDI-392749", "name": "Transport of L1 into endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590638" ], "products": [ "species_10590638" ], "modifiers": [], "additional_components": [ "Q54F41", "DDB_G0291131", "Q54DN5", "DDB_G0291984", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54H39", "DDB_G0289721", "Q54X82", "DDB_G0279141", "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "Q54F41", "DDB_G0291131", "Q54DN5", "DDB_G0291984", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54H39", "DDB_G0289721", "Q54X82", "DDB_G0279141", "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139" ] }, "reaction_10594030": { "compartment": "compartment_876", "id": "reaction_10594030", "reactome": "R-DDI-555065", "name": "Formation of clathrin coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10585860", "species_10594019" ], "products": [ "species_10590638", "species_29372", "species_29420" ], "modifiers": [ [ "species_10594027", "catalyst" ] ], "additional_components": [ "Q54F41", "DDB_G0291131", "Q54DN5", "DDB_G0291984", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54H39", "DDB_G0289721", "Q54X82", "DDB_G0279141", "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "Q54F41", "DDB_G0291131", "Q54DN5", "DDB_G0291984", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54H39", "DDB_G0289721", "Q54X82", "DDB_G0279141", "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139" ] }, "reaction_10611540": { "compartment": "compartment_5460", "id": "reaction_10611540", "reactome": "R-DDI-5693977", "name": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611519", "species_200671" ], "products": [ "species_10611532", "species_5693978", "species_5693984" ], "modifiers": [ [ "species_10611537", "catalyst" ] ], "additional_components": [ "Q54JV8", "DDB_G0287773", "CHEBI:14949", "CHEBI:50746", "Q54JV8", "DDB_G0287773", "DDB_G0292326" ] }, "reaction_10611545": { "compartment": "compartment_5460", "id": "reaction_10611545", "reactome": "R-DDI-5694018", "name": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611532", "species_113526" ], "products": [ "species_10611515", "species_113529", "species_29362" ], "modifiers": [ [ "species_10611542", "catalyst" ] ], "additional_components": [ "CHEBI:50746", "Q54JV8", "DDB_G0287773", "DDB_G0287773", "Q54EW8", "DDB_G0291648", "species_113596" ] }, "reaction_10611530": { "compartment": "compartment_5460", "id": "reaction_10611530", "reactome": "R-DDI-5693967", "name": "PXLP-K754-GLDC dimer decarboxylates Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_10611515" ], "products": [ "species_10611519", "species_29376" ], "modifiers": [ [ "species_10611527", "catalyst" ] ], "additional_components": [ "DDB_G0287773", "Q54JV8", "DDB_G0287773", "CHEBI:14949", "Q54KM7", "DDB_G0287255" ] }, "reaction_10590766": { "compartment": "compartment_70101", "id": "reaction_10590766", "reactome": "R-DDI-418456", "name": "cGMP is degraded by PDEs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30991" ], "products": [ "species_113578" ], "modifiers": [ [ "species_10590763", "catalyst" ] ], "additional_components": [ "B0G0Y8", "DDB_G0268634", "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121" ] }, "reaction_10590749": { "compartment": "compartment_70101", "id": "reaction_10590749", "reactome": "R-DDI-418436", "name": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468", "species_29368", "species_29364" ], "products": [ "species_202124", "species_29366", "species_29968" ], "modifiers": [ [ "species_10590744", "catalyst" ] ], "additional_components": [ "DDB_G0269912" ] }, "reaction_10618498": { "compartment": "compartment_12045", "id": "reaction_10618498", "reactome": "R-DDI-8848585", "name": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200993", "species_30209" ], "products": [ "species_76194", "species_2534407" ], "modifiers": [ [ "species_10611937", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10590501": { "compartment": "compartment_17951", "id": "reaction_10590501", "reactome": "R-DDI-390425", "name": "FAR1 reduces PalmCoA to HXOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200993" ], "products": [ "species_29366", "species_8848577", "species_76194" ], "modifiers": [ [ "species_10590498", "catalyst" ] ], "additional_components": [ "DDB_G0289081" ] }, "reaction_10590503": { "compartment": "compartment_17951", "id": "reaction_10590503", "reactome": "R-DDI-390438", "name": "FAR2 reduces PalmCoA to HXOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200993" ], "products": [ "species_29366", "species_8848577", "species_76194" ], "modifiers": [ [ "species_10590498", "catalyst" ] ], "additional_components": [ "DDB_G0289081" ] }, "reaction_10618495": { "compartment": "compartment_12045", "id": "reaction_10618495", "reactome": "R-DDI-8848582", "name": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848577", "species_200993" ], "products": [ "species_8848499", "species_76194" ], "modifiers": [ [ "species_10611937", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10611935": { "compartment": "compartment_12045", "id": "reaction_10611935", "reactome": "R-DDI-5696424", "name": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192172", "species_5696426" ], "products": [ "species_5696412", "species_162743" ], "modifiers": [ [ "species_10611932", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10588683": { "compartment": "compartment_70101", "id": "reaction_10588683", "reactome": "R-DDI-209828", "name": "Tryptophan is hydroxylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_29500", "species_29368" ], "products": [ "species_71112", "species_209911" ], "modifiers": [ [ "species_10588680", "catalyst" ] ], "additional_components": [ "Q54XS1", "DDB_G0278781", "species_71067" ] }, "reaction_10588667": { "compartment": "compartment_70101", "id": "reaction_10588667", "reactome": "R-DDI-209821", "name": "Methylation of N-acetyl-5-HT to form melatonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_209793" ], "products": [ "species_209934", "species_70106", "species_71285" ], "modifiers": [ [ "species_10588664", "catalyst" ] ], "additional_components": [ "Q86I40", "DDB_G0275013", "Q54B59", "DDB_G0293888", "Q54GZ0", "DDB_G0289823", "Q54S95", "DDB_G0282591", "Q8T638", "DDB_G0289329", "Q54B60", "DDB_G0293886", "Q54FP4", "DDB_G0290719", "Q86HS9", "DDB_G0274941" ] }, "reaction_10606827": { "compartment": "compartment_17938", "id": "reaction_10606827", "reactome": "R-DDI-5672010", "name": "Active MTORC1 phosphorylates ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10606817" ], "products": [ "species_29370", "species_10606824" ], "modifiers": [ [ "species_10606817", "catalyst" ] ], "additional_components": [ "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54J54", "DDB_G0288287", "Q86CS2", "DDB_G0292390", "Q55BY0", "DDB_G0269162", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390" ] }, "reaction_10607979": { "compartment": "compartment_12045", "id": "reaction_10607979", "reactome": "R-DDI-5682385", "name": "The phagophore extends from the PIP3-enriched structure", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606839" ], "products": [ "species_10607970" ], "modifiers": [ [ "species_10607975", "catalyst" ] ], "additional_components": [ "Q54JI9", "DDB_G0288021", "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "Q54JI9", "DDB_G0288021", "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "DDB_G0285323" ] }, "reaction_10626468": { "compartment": "compartment_70101", "id": "reaction_10626468", "reactome": "R-DDI-9641089", "name": "Parkin binds Ub:UBE2N:UBE2V1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596322", "species_10626464" ], "products": [ "species_10626466" ], "modifiers": [], "additional_components": [ "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043" ] }, "reaction_10626478": { "compartment": "compartment_70101", "id": "reaction_10626478", "reactome": "R-DDI-9641096", "name": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626474", "species_10626466" ], "products": [ "species_10626476" ], "modifiers": [], "additional_components": [ "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151" ] }, "reaction_10626510": { "compartment": "compartment_70101", "id": "reaction_10626510", "reactome": "R-DDI-9641127", "name": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626506" ], "products": [ "species_10626492" ], "modifiers": [], "additional_components": [ "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54U44", "DDB_G0280973", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54U44", "DDB_G0280973", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765" ] }, "reaction_10626494": { "compartment": "compartment_70101", "id": "reaction_10626494", "reactome": "R-DDI-9641109", "name": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626492" ], "products": [ "species_10626490", "species_10626480" ], "modifiers": [], "additional_components": [ "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54U44", "DDB_G0280973", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54U44", "DDB_G0280973", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596" ] }, "reaction_10626559": { "compartment": "compartment_18667", "id": "reaction_10626559", "reactome": "R-DDI-9646685", "name": "Aggresome dissociates from dynein and microtubule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626551" ], "products": [ "species_10626557", "species_10589898", "species_10605681" ], "modifiers": [], "additional_components": [ "P54703", "DDB_G0280849", "Q86A88", "DDB_G0274815", "Q54CI8", "DDB_G0292904", "P34036", "DDB_G0276355", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54U44", "DDB_G0280973", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54X15", "DDB_G0279267", "species_29438", "species_29420", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54U44", "DDB_G0280973", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54X15", "DDB_G0279267", "species_29438", "species_29420", "P54703", "DDB_G0280849", "Q86A88", "DDB_G0274815", "Q54CI8", "DDB_G0292904", "P34036", "DDB_G0276355" ] }, "reaction_10626508": { "compartment": "compartment_70101", "id": "reaction_10626508", "reactome": "R-DDI-9641111", "name": "Parkin transfers Ub to misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626476" ], "products": [ "species_10626506" ], "modifiers": [], "additional_components": [ "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54U44", "DDB_G0280973", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765" ] }, "reaction_10626541": { "compartment": "compartment_70101", "id": "reaction_10626541", "reactome": "R-DDI-9646348", "name": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626537", "species_10605681" ], "products": [ "species_10626539" ], "modifiers": [], "additional_components": [ "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54U44", "DDB_G0280973", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54X15", "DDB_G0279267", "P54703", "DDB_G0280849", "Q86A88", "DDB_G0274815", "Q54CI8", "DDB_G0292904", "P34036", "DDB_G0276355", "P54703", "DDB_G0280849", "Q86A88", "DDB_G0274815", "Q54CI8", "DDB_G0292904", "P34036", "DDB_G0276355", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54U44", "DDB_G0280973", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54X15", "DDB_G0279267" ] }, "reaction_10623347": { "compartment": "compartment_70101", "id": "reaction_10623347", "reactome": "R-DDI-8948039", "name": "FUNDC1 is phosphorylated by CK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623342", "species_113592" ], "products": [ "species_29370", "species_10623345" ], "modifiers": [ [ "species_10601344", "catalyst" ] ], "additional_components": [ "DDB_G0277699", "DDB_G0277699", "Q54PF1", "DDB_G0284601", "Q02720", "DDB_G0276885", "Q54LR6", "DDB_G0286481" ] }, "reaction_10623360": { "compartment": "compartment_17906", "id": "reaction_10623360", "reactome": "R-DDI-8948146", "name": "FUNDC1 is phosphorylated by ULK1 at Ser17", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623342", "species_113592" ], "products": [ "species_10623357", "species_29370" ], "modifiers": [ [ "species_10623349", "catalyst" ] ], "additional_components": [ "DDB_G0277699", "DDB_G0277699", "DDB_G0292390" ] }, "reaction_10623351": { "compartment": "compartment_17906", "id": "reaction_10623351", "reactome": "R-DDI-8948136", "name": "ULK1 Translocates to the mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606654" ], "products": [ "species_10623349" ], "modifiers": [], "additional_components": [ "DDB_G0292390", "DDB_G0292390" ] }, "reaction_10624119": { "compartment": "compartment_21994", "id": "reaction_10624119", "reactome": "R-DDI-8959571", "name": "LC3 binds the autophagosome membrane Atg5-Atg12 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604606", "species_10624115" ], "products": [ "species_10624117" ], "modifiers": [], "additional_components": [ "Q86CR6", "DDB_G0282929", "Q54GT9", "DDB_G0289881", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q75K07", "DDB_G0277699", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q75K07", "DDB_G0277699", "Q86CR6", "DDB_G0282929", "Q54GT9", "DDB_G0289881" ] }, "reaction_10624121": { "compartment": "compartment_70101", "id": "reaction_10624121", "reactome": "R-DDI-8959573", "name": "Phosphorylated FUNDC1 links damaged mitochondria to LC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623357", "species_10624113" ], "products": [ "species_10624115" ], "modifiers": [], "additional_components": [ "DDB_G0277699", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q75K07", "DDB_G0277699" ] }, "reaction_10627184": { "compartment": "compartment_17947", "id": "reaction_10627184", "reactome": "R-DDI-9664880", "name": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627180", "species_10607651" ], "products": [ "species_10627182" ], "modifiers": [], "additional_components": [ "Q54Q21", "DDB_G0284133", "Q55CE3", "DDB_G0270098", "Q54MD1", "DDB_G0286033", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q54Q21", "DDB_G0284133", "Q55CE3", "DDB_G0270098", "Q54MD1", "DDB_G0286033" ] }, "reaction_10627166": { "compartment": "compartment_17947", "id": "reaction_10627166", "reactome": "R-DDI-9664867", "name": "NBR1 binds MAP1LC3B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627162", "species_10607651" ], "products": [ "species_10627164" ], "modifiers": [], "additional_components": [ "DDB_G0284133", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q54Q21", "DDB_G0284133" ] }, "reaction_10606829": { "compartment": "compartment_70101", "id": "reaction_10606829", "reactome": "R-DDI-5672011", "name": "p-AMPK:AMP binds the ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606668", "species_10589958" ], "products": [ "species_10606670" ], "modifiers": [], "additional_components": [ "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390" ] }, "reaction_10607596": { "compartment": "compartment_70101", "id": "reaction_10607596", "reactome": "R-DDI-5676229", "name": "WIPIs bind PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693050", "species_10607592" ], "products": [ "species_10607594" ], "modifiers": [], "additional_components": [ "Q54NA2", "DDB_G0285375", "Q54NA2", "DDB_G0285375", "species_1806200" ] }, "reaction_10607732": { "compartment": "compartment_70101", "id": "reaction_10607732", "reactome": "R-DDI-5679205", "name": "ULK1 phosphorylates Beclin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607717" ], "products": [ "species_29370", "species_10606839" ], "modifiers": [ [ "species_10607729", "catalyst" ] ], "additional_components": [ "Q54JI9", "DDB_G0288021", "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "Q54JI9", "DDB_G0288021", "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390" ] }, "reaction_10608055": { "compartment": "compartment_70101", "id": "reaction_10608055", "reactome": "R-DDI-5683593", "name": "ATG7:ATG3:LC3 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607764" ], "products": [ "species_10607673", "species_10607749" ], "modifiers": [], "additional_components": [ "Q86CR9", "DDB_G0271096", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q550A8", "DDB_G0277319", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q550A8", "DDB_G0277319", "Q86CR9", "DDB_G0271096" ] }, "reaction_10607737": { "compartment": "compartment_70101", "id": "reaction_10607737", "reactome": "R-DDI-5679206", "name": "MTMR14, MTMR3 dephosphorylate PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676030" ], "products": [ "species_426639" ], "modifiers": [ [ "species_10607734", "catalyst" ] ], "additional_components": [ "Q54H00", "DDB_G0289807", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258" ] }, "reaction_10607739": { "compartment": "compartment_70101", "id": "reaction_10607739", "reactome": "R-DDI-5679239", "name": "ULK complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607573" ], "products": [ "species_10607729" ], "modifiers": [], "additional_components": [ "Q54J54", "DDB_G0288287", "Q86CS2", "DDB_G0292390", "Q55BY0", "DDB_G0269162", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390" ] }, "reaction_10606842": { "compartment": "compartment_12045", "id": "reaction_10606842", "reactome": "R-DDI-5672012", "name": "Beclin-1 complex phosphorylates PtdIns", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426639" ], "products": [ "species_29370", "species_5676030" ], "modifiers": [ [ "species_10606839", "catalyst" ] ], "additional_components": [ "Q54JI9", "DDB_G0288021", "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627" ] }, "reaction_10607741": { "compartment": "compartment_70101", "id": "reaction_10607741", "reactome": "R-DDI-5679255", "name": "WIPI2 binds ATG12:ATG5:ATG16L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607693", "species_10607691" ], "products": [ "species_10607695" ], "modifiers": [], "additional_components": [ "species_1806205", "Q54NA2", "DDB_G0285375", "O15736", "DDB_G0275323", "Q86CR6", "DDB_G0282929", "Q54GT9", "DDB_G0289881", "O15736", "DDB_G0275323", "Q86CR6", "DDB_G0282929", "Q54GT9", "DDB_G0289881", "species_1806205", "Q54NA2", "DDB_G0285375" ] }, "reaction_10606846": { "compartment": "compartment_17938", "id": "reaction_10606846", "reactome": "R-DDI-5672017", "name": "Rheb in the MTORC1 complex hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584242" ], "products": [ "species_10589976" ], "modifiers": [ [ "species_10584242", "catalyst" ] ], "additional_components": [ "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318" ] }, "reaction_10607747": { "compartment": "compartment_70101", "id": "reaction_10607747", "reactome": "R-DDI-5679266", "name": "Beclin-1 complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607745" ], "products": [ "species_10607717" ], "modifiers": [], "additional_components": [ "Q54JI9", "DDB_G0288021", "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "Q54JI9", "DDB_G0288021", "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627" ] }, "reaction_10606850": { "compartment": "compartment_70101", "id": "reaction_10606850", "reactome": "R-DDI-5672817", "name": "Active MTORC1 binds the ULK1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606668", "species_10584242" ], "products": [ "species_10606817" ], "modifiers": [], "additional_components": [ "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390" ] }, "reaction_10607753": { "compartment": "compartment_70101", "id": "reaction_10607753", "reactome": "R-DDI-5681980", "name": "ATG12 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607684", "species_10607749" ], "products": [ "species_10607751" ], "modifiers": [], "additional_components": [ "DDB_G0282929", "Q86CR9", "DDB_G0271096", "Q86CR9", "DDB_G0271096", "Q86CR6", "DDB_G0282929" ] }, "reaction_10607564": { "compartment": "compartment_74700", "id": "reaction_10607564", "reactome": "R-DDI-5675790", "name": "MTORC1 dissociates from ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607256" ], "products": [ "species_10606822", "species_10584309" ], "modifiers": [], "additional_components": [ "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54J54", "DDB_G0288287", "Q86CS2", "DDB_G0292390", "Q55BY0", "DDB_G0269162", "Q54J54", "DDB_G0288287", "Q86CS2", "DDB_G0292390", "Q55BY0", "DDB_G0269162", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318" ] }, "reaction_10625487": { "compartment": "compartment_70101", "id": "reaction_10625487", "reactome": "R-DDI-9020616", "name": "ATG12 forms a thioester bond with ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607751" ], "products": [ "species_10608021" ], "modifiers": [], "additional_components": [ "Q86CR9", "DDB_G0271096", "Q86CR6", "DDB_G0282929", "Q86CR6", "DDB_G0282929", "Q86CR9", "DDB_G0271096" ] }, "reaction_10608017": { "compartment": "compartment_5683628", "id": "reaction_10608017", "reactome": "R-DDI-5682388", "name": "Autophagosome maturation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607675" ], "products": [ "species_10608008" ], "modifiers": [ [ "species_10608015", "catalyst" ], [ "species_10594491", "catalyst" ] ], "additional_components": [ "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "species_1500581", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "species_1500581", "Q54JI9", "DDB_G0288021", "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "Q54JC5", "DDB_G0288175", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54P63", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q86H98", "DDB_G0275573" ] }, "reaction_10607824": { "compartment": "compartment_70101", "id": "reaction_10607824", "reactome": "R-DDI-5681987", "name": "LC3 is cleaved by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607793" ], "products": [ "species_10607665" ], "modifiers": [ [ "species_10607821", "catalyst" ] ], "additional_components": [ "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q557H7", "DDB_G0273443" ] }, "reaction_10607826": { "compartment": "compartment_70101", "id": "reaction_10607826", "reactome": "R-DDI-5682011", "name": "LC3 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607749", "species_10607665" ], "products": [ "species_10607760" ], "modifiers": [], "additional_components": [ "Q86CR9", "DDB_G0271096", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096" ] }, "reaction_10607698": { "compartment": "compartment_70101", "id": "reaction_10607698", "reactome": "R-DDI-5678490", "name": "ATG16L1 complex transfers LC3 from ATG3 to PE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5681998", "species_10607673" ], "products": [ "species_10607677", "species_10607675" ], "modifiers": [ [ "species_10607695", "catalyst" ] ], "additional_components": [ "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q550A8", "DDB_G0277319", "DDB_G0277319", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "species_1500581", "O15736", "DDB_G0275323", "Q86CR6", "DDB_G0282929", "Q54GT9", "DDB_G0289881", "species_1806205", "Q54NA2", "DDB_G0285375" ] }, "reaction_10608023": { "compartment": "compartment_70101", "id": "reaction_10608023", "reactome": "R-DDI-5682896", "name": "LC3:ATG7 dimer binds ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607677", "species_10607760" ], "products": [ "species_10607762" ], "modifiers": [], "additional_components": [ "DDB_G0277319", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096", "Q550A8", "DDB_G0277319" ] }, "reaction_10607767": { "compartment": "compartment_70101", "id": "reaction_10607767", "reactome": "R-DDI-5681981", "name": "ATG3 transfers LC3 from ATG7 to ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607762" ], "products": [ "species_10607764" ], "modifiers": [ [ "species_10607762", "catalyst" ] ], "additional_components": [ "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096", "Q550A8", "DDB_G0277319", "Q86CR9", "DDB_G0271096", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q550A8", "DDB_G0277319", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096", "Q550A8", "DDB_G0277319" ] }, "reaction_10607576": { "compartment": "compartment_70101", "id": "reaction_10607576", "reactome": "R-DDI-5675868", "name": "ULK1 phosphorylates ATG13 and RB1CC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606812", "species_113592" ], "products": [ "species_29370", "species_10607573" ], "modifiers": [ [ "species_10606812", "catalyst" ] ], "additional_components": [ "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54J54", "DDB_G0288287", "Q86CS2", "DDB_G0292390", "Q55BY0", "DDB_G0269162", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390" ] }, "reaction_10607258": { "compartment": "compartment_70101", "id": "reaction_10607258", "reactome": "R-DDI-5673768", "name": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10606824" ], "products": [ "species_29370", "species_10607256" ], "modifiers": [ [ "species_10589958", "catalyst" ] ], "additional_components": [ "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54J54", "DDB_G0288287", "Q86CS2", "DDB_G0292390", "Q55BY0", "DDB_G0269162", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54J54", "DDB_G0288287", "Q86CS2", "DDB_G0292390", "Q55BY0", "DDB_G0269162", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643" ] }, "reaction_10608090": { "compartment": "compartment_70101", "id": "reaction_10608090", "reactome": "R-DDI-5683925", "name": "ULK1 is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606822" ], "products": [ "species_10606668", "species_29372" ], "modifiers": [], "additional_components": [ "Q54J54", "DDB_G0288287", "Q86CS2", "DDB_G0292390", "Q55BY0", "DDB_G0269162", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390" ] }, "reaction_10606684": { "compartment": "compartment_70101", "id": "reaction_10606684", "reactome": "R-DDI-5665868", "name": "AMPK (complex) phosphorylates ULK1 (complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606670", "species_113592" ], "products": [ "species_29370", "species_10606681" ], "modifiers": [ [ "species_10606670", "catalyst" ] ], "additional_components": [ "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54J54", "DDB_G0288287", "Q86CS2", "DDB_G0292390", "Q55BY0", "DDB_G0269162", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390" ] }, "reaction_10606815": { "compartment": "compartment_70101", "id": "reaction_10606815", "reactome": "R-DDI-5672008", "name": "Thr-180 of ULK1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10606681" ], "products": [ "species_10606812", "species_29370" ], "modifiers": [ [ "species_10606681", "catalyst" ] ], "additional_components": [ "Q54J54", "DDB_G0288287", "Q86CS2", "DDB_G0292390", "Q55BY0", "DDB_G0269162", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54J54", "DDB_G0288287", "Q86CS2", "DDB_G0292390", "Q55BY0", "DDB_G0269162", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643" ] }, "reaction_10607966": { "compartment": "compartment_70101", "id": "reaction_10607966", "reactome": "R-DDI-5682377", "name": "LC3 de-lipidation by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607675" ], "products": [ "species_5681998", "species_10607665" ], "modifiers": [ [ "species_10607821", "catalyst" ] ], "additional_components": [ "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "species_1500581", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q557H7", "DDB_G0273443" ] }, "reaction_10611248": { "compartment": "compartment_70101", "id": "reaction_10611248", "reactome": "R-DDI-5691512", "name": "APEH hydrolyses NAc-Ser-protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5691496", "species_29356" ], "products": [ "species_6785226", "species_5691517" ], "modifiers": [ [ "species_10611245", "catalyst" ] ], "additional_components": [ "species_5691517", "species_6785219", "DDB_G0267742" ] }, "reaction_10616060": { "compartment": "compartment_70101", "id": "reaction_10616060", "reactome": "R-DDI-6800138", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616038", "species_71284" ], "products": [ "species_10616045", "species_71285" ], "modifiers": [ [ "species_10616057", "catalyst" ] ], "additional_components": [ "Q7YZN9", "DDB_G0277919", "species_29438", "Q9BMX0", "DDB_G0288613", "Q7YZN9", "DDB_G0277919", "species_29438", "Q9BMX0", "DDB_G0288613", "Q54DT3", "DDB_G0292048", "Q54N57", "DDB_G0285489" ] }, "reaction_10601939": { "compartment": "compartment_13231", "id": "reaction_10601939", "reactome": "R-DDI-3000449", "name": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10601921" ], "products": [ "species_10601725", "species_10601936" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54N16", "DDB_G0285563", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54N16", "DDB_G0285563", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10626247": { "compartment": "compartment_1598585", "id": "reaction_10626247", "reactome": "R-DDI-9624845", "name": "RCC1 stimulates GDP to GTP exchange on RAN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10587842" ], "products": [ "species_10626239", "species_29420" ], "modifiers": [ [ "species_10626244", "catalyst" ] ], "additional_components": [ "P33519", "DDB_G0291235", "species_29420", "P33519", "DDB_G0291235", "species_29438", "DDB_G0270246" ] }, "reaction_10626251": { "compartment": "compartment_70101", "id": "reaction_10626251", "reactome": "R-DDI-9624876", "name": "RAN:GTP recruits nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9624879", "species_10626239" ], "products": [ "species_10626249" ], "modifiers": [], "additional_components": [ "P33519", "DDB_G0291235", "species_29438", "P33519", "DDB_G0291235", "species_29438" ] }, "reaction_10626254": { "compartment": "compartment_70101", "id": "reaction_10626254", "reactome": "R-DDI-9624893", "name": "RAN stimulates fusion of nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10626249" ], "products": [ "species_29372", "species_9624890", "species_10587842" ], "modifiers": [ [ "species_10601936", "catalyst" ] ], "additional_components": [ "P33519", "DDB_G0291235", "species_29438", "P33519", "DDB_G0291235", "species_29420", "Q54N16", "DDB_G0285563", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10627210": { "compartment": "compartment_13231", "id": "reaction_10627210", "reactome": "R-DDI-9668395", "name": "CHMP7 binds CC2D1B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627194", "species_10627200" ], "products": [ "species_10627202" ], "modifiers": [], "additional_components": [ "DDB_G0283793", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54P63", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54P63", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54QK5", "DDB_G0283793" ] }, "reaction_10627208": { "compartment": "compartment_70101", "id": "reaction_10627208", "reactome": "R-DDI-9668389", "name": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594774", "species_10627204" ], "products": [ "species_10627206" ], "modifiers": [], "additional_components": [ "DDB_G0284347", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54P63", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54QK5", "DDB_G0283793", "Q54KQ7", "DDB_G0287165", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54P63", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54QK5", "DDB_G0283793", "Q54KQ7", "DDB_G0287165", "Q54PT2", "DDB_G0284347" ] }, "reaction_10627215": { "compartment": "compartment_70101", "id": "reaction_10627215", "reactome": "R-DDI-9668419", "name": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10589898", "species_113592" ], "products": [ "species_29372", "species_29370", "species_10589894" ], "modifiers": [ [ "species_10627204", "catalyst" ] ], "additional_components": [ "species_29438", "species_29420", "species_29438", "species_29420", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54P63", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54QK5", "DDB_G0283793", "Q54KQ7", "DDB_G0287165" ] }, "reaction_10627212": { "compartment": "compartment_70101", "id": "reaction_10627212", "reactome": "R-DDI-9668405", "name": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627189", "species_10627202" ], "products": [ "species_10627204" ], "modifiers": [], "additional_components": [ "DDB_G0287165", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54P63", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54QK5", "DDB_G0283793", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54P63", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54QK5", "DDB_G0283793", "Q54KQ7", "DDB_G0287165" ] }, "reaction_10606306": { "compartment": "compartment_70101", "id": "reaction_10606306", "reactome": "R-DDI-5652172", "name": "AKR1B1 reduces Glc to D-sorbitol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_70113" ], "products": [ "species_29366", "species_5652213" ], "modifiers": [ [ "species_10586772", "catalyst" ] ], "additional_components": [ "Q55FL3", "DDB_G0268058", "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562" ] }, "reaction_10577683": { "compartment": "compartment_70101", "id": "reaction_10577683", "reactome": "R-DDI-70333", "name": "KHK dimer phosphorylates Fru to Fru 1-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29532", "species_113592" ], "products": [ "species_29370", "species_31221" ], "modifiers": [ [ "species_10577680", "catalyst" ], [ "species_29804", "catalyst" ], [ "species_29370", "inhibitor" ] ], "additional_components": [ "Q54D80", "DDB_G0292440" ] }, "reaction_10577703": { "compartment": "compartment_70101", "id": "reaction_10577703", "reactome": "R-DDI-70349", "name": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30393", "species_113592" ], "products": [ "species_29578", "species_29370" ], "modifiers": [ [ "species_10577700", "catalyst" ] ], "additional_components": [ "Q55EE0", "DDB_G0269274", "species_29926" ] }, "reaction_10577693": { "compartment": "compartment_70101", "id": "reaction_10577693", "reactome": "R-DDI-70342", "name": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31221" ], "products": [ "species_30393", "species_75970" ], "modifiers": [ [ "species_10577690", "catalyst" ] ], "additional_components": [ "Q86A67", "DDB_G0274375" ] }, "reaction_10617821": { "compartment": "compartment_70101", "id": "reaction_10617821", "reactome": "R-DDI-6813749", "name": "ALDH1A1 oxidises GA to DGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30393", "species_29360" ], "products": [ "species_6799497", "species_70106", "species_73473" ], "modifiers": [ [ "species_10578688", "catalyst" ] ], "additional_components": [ "Q54IU0", "DDB_G0288521" ] }, "reaction_10605267": { "compartment": "compartment_7660", "id": "reaction_10605267", "reactome": "R-DDI-5358510", "name": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605263", "species_10577431", "species_10605249" ], "products": [ "species_10605265" ], "modifiers": [], "additional_components": [ "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_113592", "Q54K47", "DDB_G0287607", "Q54KD8", "DDB_G0287393", "Q54QA0", "DDB_G0283981", "Q54KD8", "DDB_G0287393", "Q54QA0", "DDB_G0283981", "Q54K47", "DDB_G0287607", "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_113592" ] }, "reaction_10605283": { "compartment": "compartment_7660", "id": "reaction_10605283", "reactome": "R-DDI-5358518", "name": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605265" ], "products": [ "species_10605280" ], "modifiers": [ [ "species_10605265", "catalyst" ] ], "additional_components": [ "Q54KD8", "DDB_G0287393", "Q54QA0", "DDB_G0283981", "Q54K47", "DDB_G0287607", "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_113592", "Q54KD8", "DDB_G0287393", "Q54QA0", "DDB_G0283981", "Q54K47", "DDB_G0287607", "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_113592", "Q54KD8", "DDB_G0287393", "Q54QA0", "DDB_G0283981", "Q54K47", "DDB_G0287607", "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_113592" ] }, "reaction_10605300": { "compartment": "compartment_7660", "id": "reaction_10605300", "reactome": "R-DDI-5358597", "name": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605296", "species_10605280" ], "products": [ "species_10605298" ], "modifiers": [], "additional_components": [ "DDB_G0291570", "Q54KD8", "DDB_G0287393", "Q54QA0", "DDB_G0283981", "Q54K47", "DDB_G0287607", "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_113592", "Q54KD8", "DDB_G0287393", "Q54QA0", "DDB_G0283981", "Q54ED2", "DDB_G0291570", "Q54K47", "DDB_G0287607", "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_113592" ] }, "reaction_10605302": { "compartment": "compartment_7660", "id": "reaction_10605302", "reactome": "R-DDI-5358912", "name": "MSH2:MSH6 exchanges ADP for ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10605287" ], "products": [ "species_113582", "species_10605263" ], "modifiers": [], "additional_components": [ "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_29370", "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_113592" ] }, "reaction_10605289": { "compartment": "compartment_7660", "id": "reaction_10605289", "reactome": "R-DDI-5358525", "name": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605285", "species_5358514" ], "products": [ "species_10605287" ], "modifiers": [], "additional_components": [ "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_29370", "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_29370" ] }, "reaction_10605291": { "compartment": "compartment_7660", "id": "reaction_10605291", "reactome": "R-DDI-5358592", "name": "DNA ligase I ligates single stranded nick in double stranded DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_5358610" ], "products": [ "species_109966", "species_164121", "species_113541" ], "modifiers": [ [ "species_10577488", "catalyst" ] ], "additional_components": [ "DDB_G0274493" ] }, "reaction_10605389": { "compartment": "compartment_7660", "id": "reaction_10605389", "reactome": "R-DDI-5444516", "name": "Formation of MSH2:MSH6 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113582", "species_10605259", "species_10605254" ], "products": [ "species_10605285" ], "modifiers": [], "additional_components": [ "DDB_G0268614", "DDB_G0275809", "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_29370" ] }, "reaction_10605391": { "compartment": "compartment_7660", "id": "reaction_10605391", "reactome": "R-DDI-5444523", "name": "Formation of MSH1:PMS2 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605247", "species_10605242" ], "products": [ "species_10605249" ], "modifiers": [], "additional_components": [ "DDB_G0283981", "DDB_G0287393", "Q54KD8", "DDB_G0287393", "Q54QA0", "DDB_G0283981" ] }, "reaction_10605387": { "compartment": "compartment_7660", "id": "reaction_10605387", "reactome": "R-DDI-5444511", "name": "Formation of MSH2:MSH3 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113582", "species_10605272", "species_10605254" ], "products": [ "species_10605274" ], "modifiers": [], "additional_components": [ "DDB_G0281683", "DDB_G0275809", "Q553L4", "DDB_G0275809", "Q1ZXH0", "DDB_G0281683", "species_29370" ] }, "reaction_10605278": { "compartment": "compartment_7660", "id": "reaction_10605278", "reactome": "R-DDI-5358513", "name": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5358527", "species_10605274" ], "products": [ "species_10605276" ], "modifiers": [], "additional_components": [ "Q553L4", "DDB_G0275809", "Q1ZXH0", "DDB_G0281683", "species_29370", "Q553L4", "DDB_G0275809", "Q1ZXH0", "DDB_G0281683", "species_29370" ] }, "reaction_10582371": { "compartment": "compartment_7660", "id": "reaction_10582371", "reactome": "R-DDI-77071", "name": "Phosphorylation (Ser5) of RNA pol II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10582368" ], "products": [ "species_113582", "species_10582364" ], "modifiers": [ [ "species_10582368", "catalyst" ] ], "additional_components": [ "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729" ] }, "reaction_10582386": { "compartment": "compartment_7660", "id": "reaction_10582386", "reactome": "R-DDI-77073", "name": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582382", "species_10582376", "species_10582360" ], "products": [ "species_10582384" ], "modifiers": [], "additional_components": [ "DDB_G0287661", "DDB_G0278479", "Q54HV6", "DDB_G0289199", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661" ] }, "reaction_10582362": { "compartment": "compartment_7660", "id": "reaction_10582362", "reactome": "R-DDI-77068", "name": "Activation of GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582360" ], "products": [ "species_10582360" ], "modifiers": [], "additional_components": [ "Q54HV6", "DDB_G0289199", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10583326": { "compartment": "compartment_7660", "id": "reaction_10583326", "reactome": "R-DDI-113430", "name": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582368" ], "products": [ "species_10582368" ], "modifiers": [], "additional_components": [ "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729" ] }, "reaction_10582366": { "compartment": "compartment_7660", "id": "reaction_10582366", "reactome": "R-DDI-77069", "name": "RNA Polymerase II CTD (phosphorylated) binds to CE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582364", "species_10582358" ], "products": [ "species_10582360" ], "modifiers": [], "additional_components": [ "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "DDB_G0289199", "Q54HV6", "DDB_G0289199", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10577491": { "compartment": "compartment_7660", "id": "reaction_10577491", "reactome": "R-DDI-69173", "name": "Joining of adjacent Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_68452" ], "products": [ "species_69172" ], "modifiers": [ [ "species_10577488", "catalyst" ] ], "additional_components": [ "DDB_G0274493" ] }, "reaction_10577467": { "compartment": "compartment_7660", "id": "reaction_10577467", "reactome": "R-DDI-69116", "name": "Formation of Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577460" ], "products": [ "species_10577464" ], "modifiers": [ [ "species_10577458", "catalyst" ] ], "additional_components": [ "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609" ] }, "reaction_10577483": { "compartment": "compartment_7660", "id": "reaction_10577483", "reactome": "R-DDI-69152", "name": "Removal of remaining Flap", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577473" ], "products": [ "species_10577475" ], "modifiers": [ [ "species_10577480", "catalyst" ] ], "additional_components": [ "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "DDB_G0284987" ] }, "reaction_10577471": { "compartment": "compartment_7660", "id": "reaction_10577471", "reactome": "R-DDI-69127", "name": "Formation of the Flap Intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577464" ], "products": [ "species_10577469" ], "modifiers": [], "additional_components": [ "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731" ] }, "reaction_10595408": { "compartment": "compartment_20699", "id": "reaction_10595408", "reactome": "R-DDI-964825", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964831" ], "products": [ "species_964752", "species_964740" ], "modifiers": [ [ "species_10595395", "catalyst" ] ], "additional_components": [ "CHEBI:60629", "CHEBI:60628", "CHEBI:60627", "Q54CH4", "DDB_G0292918", "Q54PP9", "DDB_G0292918", "Q54PQ0", "DDB_G0292918", "Q54PQ1", "DDB_G0292918", "Q55EU0", "DDB_G0292918" ] }, "reaction_10595410": { "compartment": "compartment_20699", "id": "reaction_10595410", "reactome": "R-DDI-964830", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964828" ], "products": [ "species_964752", "species_964740" ], "modifiers": [ [ "species_10595395", "catalyst" ] ], "additional_components": [ "Q54CH4", "DDB_G0292918", "Q54PP9", "DDB_G0292918", "Q54PQ0", "DDB_G0292918", "Q54PQ1", "DDB_G0292918", "Q55EU0", "DDB_G0292918" ] }, "reaction_10595398": { "compartment": "compartment_20699", "id": "reaction_10595398", "reactome": "R-DDI-964737", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_915149" ], "products": [ "species_964752", "species_964740" ], "modifiers": [ [ "species_10595395", "catalyst" ] ], "additional_components": [ "Q54CH4", "DDB_G0292918", "Q54PP9", "DDB_G0292918", "Q54PQ0", "DDB_G0292918", "Q54PQ1", "DDB_G0292918", "Q55EU0", "DDB_G0292918" ] }, "reaction_10595406": { "compartment": "compartment_20699", "id": "reaction_10595406", "reactome": "R-DDI-964768", "name": "Addition of GlcNAc to the glycan on the A arm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_964740" ], "products": [ "species_964837", "species_205687" ], "modifiers": [ [ "species_10595403", "catalyst" ] ], "additional_components": [ "DDB_G0288463" ] }, "reaction_10593280": { "compartment": "compartment_70101", "id": "reaction_10593280", "reactome": "R-DDI-450466", "name": "AUF1:mRNA complex is destroyed", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593278" ], "products": [], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q86I71", "DDB_G0279695", "Q54WE9", "DDB_G0279695", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10593258": { "compartment": "compartment_70101", "id": "reaction_10593258", "reactome": "R-DDI-450434", "name": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_450444", "species_10593252" ], "products": [ "species_10593256" ], "modifiers": [], "additional_components": [ "Q54WE9", "DDB_G0279695", "Q86I71", "DDB_G0279695", "Q54WE9", "DDB_G0279695", "Q86I71", "DDB_G0279695" ] }, "reaction_10591793": { "compartment": "compartment_114584", "id": "reaction_10591793", "reactome": "R-DDI-429157", "name": "ABCC4 accumulation of dense granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370" ], "products": [ "species_114565" ], "modifiers": [ [ "species_10591790", "catalyst" ] ], "additional_components": [ "DDB_G0284867" ] }, "reaction_10589393": { "compartment": "compartment_161320", "id": "reaction_10589393", "reactome": "R-DDI-351341", "name": "Exocytosis of Proactivator polypeptide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589385" ], "products": [ "species_10589391" ], "modifiers": [], "additional_components": [ "Q54WE0", "DDB_G0279713", "Q54G42", "DDB_G0290417", "Q54G42", "DDB_G0290417", "Q54WE0", "DDB_G0279713" ] }, "reaction_10593603": { "compartment": "compartment_876", "id": "reaction_10593603", "reactome": "R-DDI-481010", "name": "Surface deployment of platelet dense granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593573" ], "products": [ "species_10593601" ], "modifiers": [], "additional_components": [ "Q54P07", "DDB_G0285051", "Q8T193", "DDB_G0294577", "Q54S62", "DDB_G0294577", "Q1ZXG2", "DDB_G0294577", "Q54S63", "DDB_G0282651", "Q1ZXN9", "DDB_G0294577", "Q55EF0", "DDB_G0269262", "Q54E92", "DDB_G0291738", "Q55EG6", "DDB_G0268910", "Q54FL2", "DDB_G0290783", "Q86JC8", "DDB_G0275955", "Q54G48", "DDB_G0290407", "Q86JP5", "DDB_G0271980", "Q1ZXG2", "DDB_G0294577", "Q1ZXN9", "DDB_G0294577", "Q54E92", "DDB_G0291738", "Q54FL2", "DDB_G0290783", "Q54G48", "DDB_G0290407", "Q54P07", "DDB_G0285051", "Q54S62", "DDB_G0294577", "Q54S63", "DDB_G0282651", "Q55EF0", "DDB_G0269262", "Q55EG6", "DDB_G0268910", "Q86JC8", "DDB_G0275955", "Q86JP5", "DDB_G0271980", "Q8T193", "DDB_G0294577" ] }, "reaction_10593475": { "compartment": "compartment_876", "id": "reaction_10593475", "reactome": "R-DDI-481007", "name": "Exocytosis of platelet alpha granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593433" ], "products": [ "species_10593473" ], "modifiers": [], "additional_components": [ "Q55ET7", "DDB_G0268758", "Q55DM8", "DDB_G0269600", "Q55FE2", "DDB_G0268156", "Q86A67", "DDB_G0274375", "Q553C3", "DDB_G0275765", "Q54KR6", "DDB_G0287201", "Q8T2H0", "DDB_G0272190", "P05095", "DDB_G0268632", "Q54V78", "DDB_G0280565", "Q54PA3", "DDB_G0284679", "Q54D77", "DDB_G0292538", "Q86A67", "DDB_G0274375", "Q54KR6", "DDB_G0287201", "Q54D77", "DDB_G0292538", "Q55ET7", "DDB_G0268758", "Q8T2H0", "DDB_G0272190", "Q54PA3", "DDB_G0284679", "P05095", "DDB_G0268632", "Q54V78", "DDB_G0280565", "Q55FE2", "DDB_G0268156", "Q55DM8", "DDB_G0269600", "Q553C3", "DDB_G0275765" ] }, "reaction_10593506": { "compartment": "compartment_876", "id": "reaction_10593506", "reactome": "R-DDI-481009", "name": "Exocytosis of platelet dense granule content", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593494" ], "products": [ "species_10593504" ], "modifiers": [], "additional_components": [ "species_29438", "species_29372", "species_29370", "Q54F16", "DDB_G0291191", "P04988", "DDB_G0290957", "species_29926", "species_74112", "Q54D84", "DDB_G0292436", "species_113592", "species_209914", "species_29420", "species_113541", "species_74112", "species_29438", "species_29370", "species_113541", "species_29926", "species_209914", "species_113592", "species_29372", "P04988", "DDB_G0290957", "Q54F16", "DDB_G0291191", "species_29420", "Q54D84", "DDB_G0292436" ] }, "reaction_10593830": { "compartment": "compartment_70101", "id": "reaction_10593830", "reactome": "R-DDI-482772", "name": "Release of platelet cytosolic components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593734" ], "products": [ "species_10593828" ], "modifiers": [], "additional_components": [ "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "Q54TA6", "DDB_G0281889", "P32255", "DDB_G0287689", "Q55GQ5", "DDB_G0267420", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993", "Q54RX2", "DDB_G0282859", "Q54W22", "DDB_G0282287", "Q551W8", "DDB_G0282287", "Q54ST8", "DDB_G0282287", "Q54QM3", "DDB_G0283859", "Q54QC8", "DDB_G0283937", "Q54ZW8", "DDB_G0277343", "Q556T3", "DDB_G0273107", "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54L54", "DDB_G0286893", "Q54JD4", "DDB_G0288133", "P54686", "DDB_G0278733", "Q54K81", "DDB_G0287505", "P24639", "DDB_G0269160", "Q54PW0", "DDB_G0284261", "P54686", "DDB_G0278733", "P24639", "DDB_G0269160", "Q54PW0", "DDB_G0284261", "Q54RX2", "DDB_G0282859", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993", "Q55GQ5", "DDB_G0267420", "Q54QM3", "DDB_G0283859", "P32255", "DDB_G0287689", "Q54TA6", "DDB_G0281889", "Q54L54", "DDB_G0286893", "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54JD4", "DDB_G0288133", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "O00897", "DDB_G0269104", "Q54K81", "DDB_G0287505", "Q54QC8", "DDB_G0283937", "Q54ZW8", "DDB_G0277343", "Q54ST8", "DDB_G0282287", "Q54W22", "DDB_G0282287", "Q551W8", "DDB_G0282287", "Q556T3", "DDB_G0273107" ] }, "reaction_10593644": { "compartment": "compartment_876", "id": "reaction_10593644", "reactome": "R-DDI-481044", "name": "Surface deployment of platelet alpha granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593628" ], "products": [ "species_10593642" ], "modifiers": [], "additional_components": [ "Q55CV7", "DDB_G0270986", "Q55CW7", "DDB_G0269872", "Q55CV4", "DDB_G0270682", "Q55CV5", "DDB_G0269110", "Q55FQ9", "DDB_G0267440", "Q9BKJ9", "DDB_G0287035", "Q9XYS8", "DDB_G0267406", "Q54RR0", "DDB_G0282977", "Q9XYS8", "DDB_G0267406", "Q55FQ9", "DDB_G0267440", "Q9BKJ9", "DDB_G0287035", "Q55CV5", "DDB_G0269110", "Q55CV7", "DDB_G0270986", "Q55CW7", "DDB_G0269872", "Q55CV4", "DDB_G0270682", "Q54RR0", "DDB_G0282977" ] }, "reaction_10622966": { "compartment": "compartment_70101", "id": "reaction_10622966", "reactome": "R-DDI-8936849", "name": "AHR:2xHSP90:AIP:PTGES3 binds TCDD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8936852", "species_10622962" ], "products": [ "species_10622964" ], "modifiers": [], "additional_components": [ "Q54R57", "DDB_G0283399", "Q55FM3", "DDB_G0268042", "P54651", "DDB_G0267400", "Q54FE2", "DDB_G0290947", "Q54R57", "DDB_G0283399", "Q55FM3", "DDB_G0268042", "P54651", "DDB_G0267400", "Q54FE2", "DDB_G0290947", "species_8936852" ] }, "reaction_10622996": { "compartment": "compartment_70101", "id": "reaction_10622996", "reactome": "R-DDI-8937169", "name": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622964" ], "products": [ "species_10622994" ], "modifiers": [], "additional_components": [ "Q54R57", "DDB_G0283399", "Q55FM3", "DDB_G0268042", "P54651", "DDB_G0267400", "Q54FE2", "DDB_G0290947", "species_8936852", "P54651", "DDB_G0267400", "Q54R57", "DDB_G0283399", "Q54FE2", "DDB_G0290947", "Q55FM3", "DDB_G0268042", "species_8936852" ] }, "reaction_10623002": { "compartment": "compartment_7660", "id": "reaction_10623002", "reactome": "R-DDI-8937191", "name": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622994" ], "products": [ "species_10623000", "species_10622998" ], "modifiers": [], "additional_components": [ "P54651", "DDB_G0267400", "Q54R57", "DDB_G0283399", "Q54FE2", "DDB_G0290947", "Q55FM3", "DDB_G0268042", "species_8936852", "P54651", "DDB_G0267400", "Q54R57", "DDB_G0283399", "Q55FM3", "DDB_G0268042", "species_8936852", "Q54FE2", "DDB_G0290947" ] }, "reaction_10616539": { "compartment": "compartment_7660", "id": "reaction_10616539", "reactome": "R-DDI-6803523", "name": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10579116", "species_10579164", "species_10616535" ], "products": [ "species_10616537" ], "modifiers": [], "additional_components": [ "DDB_G0280393", "DDB_G0284321", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54PW8", "DDB_G0284321", "Q54VI2", "DDB_G0280393" ] }, "reaction_10582577": { "compartment": "compartment_876", "id": "reaction_10582577", "reactome": "R-DDI-109700", "name": "AKT2 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10582573" ], "products": [ "species_10582559", "species_10582575" ], "modifiers": [], "additional_components": [ "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "Q556W3", "DDB_G0273293", "DDB_G0273293", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_179838" ] }, "reaction_10582601": { "compartment": "compartment_70101", "id": "reaction_10582601", "reactome": "R-DDI-109702", "name": "PDPK1 phosphorylates AKT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582575", "species_113592" ], "products": [ "species_29370", "species_10582598" ], "modifiers": [ [ "species_10582584", "catalyst" ] ], "additional_components": [ "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_179838", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_179838", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10582586": { "compartment": "compartment_876", "id": "reaction_10582586", "reactome": "R-DDI-109701", "name": "PDPK1 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10582582" ], "products": [ "species_10582584" ], "modifiers": [], "additional_components": [ "DDB_G0281471", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10583853": { "compartment": "compartment_70101", "id": "reaction_10583853", "reactome": "R-DDI-162425", "name": "p-S295-PDE3B hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10583850", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121" ] }, "reaction_10605020": { "compartment": "compartment_171062", "id": "reaction_10605020", "reactome": "R-DDI-5252133", "name": "ATP6AP1 binds V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581337", "species_10581332" ], "products": [ "species_10581339" ], "modifiers": [], "additional_components": [ "DDB_G0273483", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q55AH5", "DDB_G0271882", "Q86A77", "DDB_G0274331", "O00780", "DDB_G0275701", "Q54Z13", "DDB_G0277971", "Q76NU1", "DDB_G0277401", "P54648", "DDB_G0284473", "P54641", "DDB_G0273071", "Q86AS7", "DDB_G0274141", "Q54E04", "DDB_G0291858", "P54642", "DDB_G0274381", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q55AH5", "DDB_G0271882", "Q86A77", "DDB_G0274331", "O00780", "DDB_G0275701", "Q54Z13", "DDB_G0277971", "Q76NU1", "DDB_G0277401", "P54648", "DDB_G0284473", "P54641", "DDB_G0273071", "Q86AS7", "DDB_G0274141", "Q54E04", "DDB_G0291858", "P54642", "DDB_G0274381", "Q557I5", "DDB_G0273483" ] }, "reaction_10581342": { "compartment": "compartment_17940", "id": "reaction_10581342", "reactome": "R-DDI-74723", "name": "Endosome acidification", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106" ], "products": [ "species_74722" ], "modifiers": [ [ "species_10581339", "catalyst" ] ], "additional_components": [ "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q55AH5", "DDB_G0271882", "Q86A77", "DDB_G0274331", "O00780", "DDB_G0275701", "Q54Z13", "DDB_G0277971", "Q76NU1", "DDB_G0277401", "P54648", "DDB_G0284473", "P54641", "DDB_G0273071", "Q86AS7", "DDB_G0274141", "Q54E04", "DDB_G0291858", "P54642", "DDB_G0274381", "Q557I5", "DDB_G0273483" ] }, "reaction_10586962": { "compartment": "compartment_70101", "id": "reaction_10586962", "reactome": "R-DDI-198270", "name": "PDPK1 phosphorylates AKT at T308", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10586941", "species_113592" ], "products": [ "species_10586959", "species_29370", "species_10582584" ], "modifiers": [ [ "species_10586941", "catalyst" ] ], "additional_components": [ "Q54TW2", "DDB_G0281471", "species_179838", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "Q54TW2", "DDB_G0281471", "species_179838", "Q54TW2", "DDB_G0281471", "species_179838", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795" ] }, "reaction_10587030": { "compartment": "compartment_70101", "id": "reaction_10587030", "reactome": "R-DDI-198640", "name": "TORC2 (mTOR) phosphorylates AKT at S473", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10587009" ], "products": [ "species_10586939", "species_29370" ], "modifiers": [ [ "species_10587023", "catalyst" ], [ "species_10587028", "inhibitor" ] ], "additional_components": [ "species_179838", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_179838", "Q54D08", "DDB_G0292592", "O77203", "DDB_G0277399", "Q9Y0C9", "DDB_G0284611", "Q86C65", "DDB_G0281569", "species_179838", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "Q556W3", "DDB_G0273293" ] }, "reaction_10600856": { "compartment": "compartment_70101", "id": "reaction_10600856", "reactome": "R-DDI-2316429", "name": "PIP3 recruits PDPK1 to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10587607" ], "products": [ "species_10582584" ], "modifiers": [], "additional_components": [ "DDB_G0281471", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10600858": { "compartment": "compartment_876", "id": "reaction_10600858", "reactome": "R-DDI-2317314", "name": "AKT binds PDPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10586939", "species_10582584" ], "products": [ "species_10586941" ], "modifiers": [], "additional_components": [ "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_179838", "Q54TW2", "DDB_G0281471", "species_179838", "Q54TW2", "DDB_G0281471", "species_179838", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795" ] }, "reaction_10604751": { "compartment": "compartment_70101", "id": "reaction_10604751", "reactome": "R-DDI-5218845", "name": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604748", "species_113592" ], "products": [ "species_5218688", "species_29370", "species_10585144", "species_10585895" ], "modifiers": [ [ "species_10604744", "catalyst" ] ], "additional_components": [ "Q54Q13", "DDB_G0284177", "species_428662", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "DDB_G0284177", "DDB_G0284545" ] }, "reaction_10597490": { "compartment": "compartment_70101", "id": "reaction_10597490", "reactome": "R-DDI-1358789", "name": "Self-ubiquitination of RNF41", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10596295" ], "products": [ "species_10597487" ], "modifiers": [ [ "species_10596295", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q559W7", "DDB_G0283193", "Q55CL1", "DDB_G0283193", "Q54RD2", "DDB_G0283193", "Q559W7", "DDB_G0283193", "Q55CL1", "DDB_G0283193", "Q54RD2", "DDB_G0283193", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q559W7", "DDB_G0283193", "Q55CL1", "DDB_G0283193", "Q54RD2", "DDB_G0283193" ] }, "reaction_10599553": { "compartment": "compartment_70101", "id": "reaction_10599553", "reactome": "R-DDI-1855223", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994141" ], "products": [ "species_29370", "species_1629755" ], "modifiers": [ [ "species_10599359", "catalyst" ] ], "additional_components": [ "Q54B75", "DDB_G0293860", "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0293860", "Q55AP4", "DDB_G0293860" ] }, "reaction_10599443": { "compartment": "compartment_70101", "id": "reaction_10599443", "reactome": "R-DDI-1855193", "name": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629736" ], "products": [ "species_29370", "species_1629738" ], "modifiers": [ [ "species_10599359", "catalyst" ] ], "additional_components": [ "Q54B75", "DDB_G0293860", "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0293860", "Q55AP4", "DDB_G0293860" ] }, "reaction_10599522": { "compartment": "compartment_70101", "id": "reaction_10599522", "reactome": "R-DDI-1855219", "name": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994141" ], "products": [ "species_29372", "species_994149" ], "modifiers": [ [ "species_10599364", "catalyst" ] ], "additional_components": [ "species_29926", "Q55D87", "DDB_G0269746" ] }, "reaction_10599362": { "compartment": "compartment_70101", "id": "reaction_10599362", "reactome": "R-DDI-1855158", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_113592" ], "products": [ "species_29370", "species_1629759" ], "modifiers": [ [ "species_10599359", "catalyst" ] ], "additional_components": [ "Q54B75", "DDB_G0293860", "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0293860", "Q55AP4", "DDB_G0293860" ] }, "reaction_10599446": { "compartment": "compartment_70101", "id": "reaction_10599446", "reactome": "R-DDI-1855194", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629740" ], "products": [ "species_1629732", "species_29370" ], "modifiers": [ [ "species_10599359", "catalyst" ] ], "additional_components": [ "Q54B75", "DDB_G0293860", "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0293860", "Q55AP4", "DDB_G0293860" ] }, "reaction_10599432": { "compartment": "compartment_70101", "id": "reaction_10599432", "reactome": "R-DDI-1855179", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994141" ], "products": [ "species_29370", "species_1629770" ], "modifiers": [ [ "species_10599429", "catalyst" ] ], "additional_components": [ "DDB_G0288351" ] }, "reaction_10599370": { "compartment": "compartment_70101", "id": "reaction_10599370", "reactome": "R-DDI-1855162", "name": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994149", "species_113592" ], "products": [ "species_29370", "species_994141" ], "modifiers": [ [ "species_10599364", "catalyst" ] ], "additional_components": [ "species_29926", "Q55D87", "DDB_G0269746" ] }, "reaction_10599562": { "compartment": "compartment_70101", "id": "reaction_10599562", "reactome": "R-DDI-1855227", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629770" ], "products": [ "species_1629765", "species_29370" ], "modifiers": [ [ "species_10599359", "catalyst" ] ], "additional_components": [ "Q54B75", "DDB_G0293860", "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0293860", "Q55AP4", "DDB_G0293860" ] }, "reaction_10597363": { "compartment": "compartment_876", "id": "reaction_10597363", "reactome": "R-DDI-1296039", "name": "Activation of Ca2+ activated Potassium channels with small conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10597360", "catalyst" ] ], "additional_components": [ "Q55CX3", "DDB_G0269864" ] }, "reaction_10597350": { "compartment": "compartment_876", "id": "reaction_10597350", "reactome": "R-DDI-1296035", "name": "Activation of Ca2+ activated Potassium channels with Intermediate conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10597347", "catalyst" ] ], "additional_components": [ "DDB_G0269864" ] }, "reaction_10597483": { "compartment": "compartment_876", "id": "reaction_10597483", "reactome": "R-DDI-1299359", "name": "Activation of TALK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10597480", "catalyst" ] ], "additional_components": [ "Q86K40", "DDB_G0277255", "Q8T268", "DDB_G0277255" ] }, "reaction_10597466": { "compartment": "compartment_876", "id": "reaction_10597466", "reactome": "R-DDI-1299338", "name": "Activation of TRESK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10597463", "catalyst" ] ], "additional_components": [ "Q86K40", "DDB_G0277255", "Q8T268", "DDB_G0277255" ] }, "reaction_10597405": { "compartment": "compartment_876", "id": "reaction_10597405", "reactome": "R-DDI-1299297", "name": "Activation of THIK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10597402", "catalyst" ] ], "additional_components": [ "Q86K40", "DDB_G0277255", "Q8T268", "DDB_G0277255" ] }, "reaction_10597455": { "compartment": "compartment_876", "id": "reaction_10597455", "reactome": "R-DDI-1299318", "name": "Activation of TASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10597452", "catalyst" ] ], "additional_components": [ "Q86K40", "DDB_G0277255", "Q8T268", "DDB_G0277255" ] }, "reaction_10597434": { "compartment": "compartment_876", "id": "reaction_10597434", "reactome": "R-DDI-1299304", "name": "Activation of tandem pore domain in a weak inwardly rectifying K+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10597431", "catalyst" ] ], "additional_components": [ "Q8T268", "DDB_G0277255", "Q86K40", "DDB_G0277255" ] }, "reaction_10590872": { "compartment": "compartment_876", "id": "reaction_10590872", "reactome": "R-DDI-420688", "name": "GABAB heterodimeric receptor binds GABA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589803", "species_352003" ], "products": [ "species_10589805" ], "modifiers": [], "additional_components": [ "Q54F54", "DDB_G0291095", "Q54K09", "DDB_G0287905", "Q54ET0", "DDB_G0291356", "species_916850", "Q54F54", "DDB_G0291095", "Q54K09", "DDB_G0287905", "Q54ET0", "DDB_G0291356" ] }, "reaction_10584963": { "compartment": "compartment_876", "id": "reaction_10584963", "reactome": "R-DDI-170686", "name": "Adenylate cyclase increases the GTPase activity of Gi alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584931" ], "products": [ "species_29372", "species_10584949" ], "modifiers": [ [ "species_10584931", "catalyst" ] ], "additional_components": [ "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545", "species_29420", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29926", "Q03100", "DDB_G0281545", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545" ] }, "reaction_10584951": { "compartment": "compartment_876", "id": "reaction_10584951", "reactome": "R-DDI-170674", "name": "Dissociation of the Gi alpha:G olf complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584949" ], "products": [ "species_10583022", "species_10584933", "species_10584947" ], "modifiers": [], "additional_components": [ "species_29420", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29926", "Q03100", "DDB_G0281545", "species_29926", "Q03100", "DDB_G0281545", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29420", "species_29420", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343" ] }, "reaction_10584938": { "compartment": "compartment_876", "id": "reaction_10584938", "reactome": "R-DDI-170666", "name": "Adenylate cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584931" ], "products": [ "species_29372", "species_10584935" ], "modifiers": [ [ "species_10584931", "catalyst" ] ], "additional_components": [ "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545", "species_29420", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545" ] }, "reaction_10584940": { "compartment": "compartment_876", "id": "reaction_10584940", "reactome": "R-DDI-170671", "name": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584867", "species_10584929" ], "products": [ "species_10584931" ], "modifiers": [], "additional_components": [ "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545" ] }, "reaction_10583667": { "compartment": "compartment_7660", "id": "reaction_10583667", "reactome": "R-DDI-156661", "name": "Formation of Exon Junction Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10579667", "species_10579651" ], "products": [ "species_10579671" ], "modifiers": [], "additional_components": [ "Q54ME8", "DDB_G0286007", "Q55E21", "DDB_G0270866", "Q55BF5", "DDB_G0271312", "Q86JC5", "DDB_G0275957", "Q1ZXF6", "DDB_G0284555", "Q54LY9", "DDB_G0286297", "Q54IV3", "DDB_G0288501", "Q54SA7", "DDB_G0282569", "Q54BG2", "DDB_G0293636", "Q54PP4", "DDB_G0284403", "Q54TL3", "DDB_G0281687", "Q55CI7", "DDB_G0271014", "Q54Q46", "DDB_G0284101", "Q54J05", "DDB_G0288391", "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q553B1", "DDB_G0275443", "Q54NJ4", "DDB_G0285213", "Q55BL6", "DDB_G0270450", "Q86A14", "DDB_G0272676", "Q54B65", "DDB_G0293876", "Q55CK7", "DDB_G0270020", "Q557T0", "DDB_G0273383", "Q7KWK5", "DDB_G0276803", "Q54SG7", "DDB_G0282763", "Q54WZ0", "DDB_G0279311", "Q54CN1", "DDB_G0292846", "P36415", "DDB_G0269144", "Q54WP9", "DDB_G0279507", "Q54CT3", "DDB_G0292778", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54ZS5", "DDB_G0277375", "Q54N41", "DDB_G0285521", "Q55A46", "DDB_G0272108", "Q54XP4", "DDB_G0278819", "Q8T295", "DDB_G0274229", "Q54ST0", "DDB_G0282243", "Q553S5", "DDB_G0275407", "Q55A15", "DDB_G0272374", "Q54R72", "DDB_G0283359", "Q55AR8", "DDB_G0271788", "Q54TF6", "DDB_G0281779", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q55BU3", "DDB_G0270360", "Q55EN0", "DDB_G0269006", "Q54QF2", "DDB_G0283901", "Q54MH4", "DDB_G0285843", "Q54LV5", "DDB_G0286395", "Q54GS9", "DDB_G0289933", "Q54MH3", "DDB_G0285937", "Q1ZXB1", "DDB_G0291966", "Q54PX3", "DDB_G0291966", "Q54HF5", "DDB_G0289501", "Q54Z08", "DDB_G0277977", "Q55EC6", "DDB_G0269300", "Q55D61", "DDB_G0269192", "Q54V94", "DDB_G0280529", "Q54XS9", "DDB_G0278769", "Q54LG7", "DDB_G0286645", "Q54WL8", "DDB_G0279559", "Q54N48", "DDB_G0285507", "Q54J73", "DDB_G0288259", "Q55E68", "DDB_G0269370", "Q54ZS8", "DDB_G0277371", "Q55BS1", "DDB_G0270392", "Q55CA3", "DDB_G0270148", "Q54PX4", "DDB_G0284319", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797", "C7G084", "DDB_G0295793", "Q54TS6", "DDB_G0281585", "P54705", "DDB_G0269188", "Q86A78", "DDB_G0274577", "Q54FZ3", "DDB_G0290649", "Q54NB4", "DDB_G0285363", "Q54NB3", "DDB_G0285363", "Q55F01", "DDB_G0269054", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54PG4", "DDB_G0284573", "Q54E37", "DDB_G0291836", "Q54DH9", "DDB_G0292240", "Q9NI62", "DDB_G0269216", "Q54YS7", "DDB_G0278105", "Q54VI2", "DDB_G0280393", "Q54CE0", "DDB_G0293168", "Q54PW8", "DDB_G0284321", "Q54WE9", "DDB_G0279695", "Q86I71", "DDB_G0279695", "Q54NS6", "DDB_G0285077", "Q54LT3", "DDB_G0286425", "Q55G70", "DDB_G0267796", "Q555Z2", "DDB_G0274797", "Q54NS6", "DDB_G0285077", "Q55BF5", "DDB_G0271312", "Q86JC5", "DDB_G0275957", "Q1ZXF6", "DDB_G0284555", "Q54LY9", "DDB_G0286297", "Q54IV3", "DDB_G0288501", "Q54SA7", "DDB_G0282569", "Q54BG2", "DDB_G0293636", "Q54PP4", "DDB_G0284403", "Q54TL3", "DDB_G0281687", "Q55CI7", "DDB_G0271014", "Q54Q46", "DDB_G0284101", "Q54J05", "DDB_G0288391", "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q553B1", "DDB_G0275443", "Q54NJ4", "DDB_G0285213", "Q55BL6", "DDB_G0270450", "Q86A14", "DDB_G0272676", "Q54B65", "DDB_G0293876", "Q55CK7", "DDB_G0270020", "Q557T0", "DDB_G0273383", "Q7KWK5", "DDB_G0276803", "Q54SG7", "DDB_G0282763", "Q54WZ0", "DDB_G0279311", "Q54CN1", "DDB_G0292846", "P36415", "DDB_G0269144", "Q54WP9", "DDB_G0279507", "Q54CT3", "DDB_G0292778", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54ZS5", "DDB_G0277375", "Q54N41", "DDB_G0285521", "Q55A46", "DDB_G0272108", "Q54XP4", "DDB_G0278819", "Q8T295", "DDB_G0274229", "Q54ST0", "DDB_G0282243", "Q553S5", "DDB_G0275407", "Q55A15", "DDB_G0272374", "Q54R72", "DDB_G0283359", "Q55AR8", "DDB_G0271788", "Q54TF6", "DDB_G0281779", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q55BU3", "DDB_G0270360", "Q55EN0", "DDB_G0269006", "Q54QF2", "DDB_G0283901", "Q54LV5", "DDB_G0286395", "Q54MH4", "DDB_G0285843", "Q54GS9", "DDB_G0289933", "Q54MH3", "DDB_G0285937", "Q1ZXB1", "DDB_G0291966", "Q54PX3", "DDB_G0291966", "Q54HF5", "DDB_G0289501", "Q54Z08", "DDB_G0277977", "Q55EC6", "DDB_G0269300", "Q54V94", "DDB_G0280529", "Q54XS9", "DDB_G0278769", "Q54LG7", "DDB_G0286645", "Q54WL8", "DDB_G0279559", "Q54N48", "DDB_G0285507", "Q54J73", "DDB_G0288259", "Q55E68", "DDB_G0269370", "Q54ZS8", "DDB_G0277371", "Q55BS1", "DDB_G0270392", "Q55CA3", "DDB_G0270148", "Q54PX4", "DDB_G0284319", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797", "C7G084", "DDB_G0295793", "Q54TS6", "DDB_G0281585", "P54705", "DDB_G0269188", "Q86A78", "DDB_G0274577", "Q54FZ3", "DDB_G0290649", "Q54NB4", "DDB_G0285363", "Q54NB3", "DDB_G0285363", "Q55F01", "DDB_G0269054", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54PG4", "DDB_G0284573", "Q54E37", "DDB_G0291836", "Q54DH9", "DDB_G0292240", "Q9NI62", "DDB_G0269216", "Q54YS7", "DDB_G0278105", "Q54VI2", "DDB_G0280393", "Q54CE0", "DDB_G0293168", "Q54PW8", "DDB_G0284321", "Q54WE9", "DDB_G0279695", "Q86I71", "DDB_G0279695", "Q54LT3", "DDB_G0286425", "Q54ME8", "DDB_G0286007", "Q55E21", "DDB_G0270866", "Q55D61", "DDB_G0269192", "Q55G70", "DDB_G0267796", "Q555Z2", "DDB_G0274797" ] }, "reaction_10579653": { "compartment": "compartment_7660", "id": "reaction_10579653", "reactome": "R-DDI-72143", "name": "Lariat Formation and 5'-Splice Site Cleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10579647", "species_10579642", "species_10579627", "species_10579637", "species_10579635" ], "products": [ "species_10579651" ], "modifiers": [], "additional_components": [ "DDB_G0269054", "DDB_G0284573", "Q55G70", "DDB_G0267796", "Q54LT3", "DDB_G0286425", "Q54NS6", "DDB_G0285077", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55BF5", "DDB_G0271312", "Q86JC5", "DDB_G0275957", "Q1ZXF6", "DDB_G0284555", "Q54LY9", "DDB_G0286297", "Q54IV3", "DDB_G0288501", "Q54SA7", "DDB_G0282569", "Q54BG2", "DDB_G0293636", "Q54PP4", "DDB_G0284403", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10579612", "species_10579597", "species_10579592", "species_10579497", "species_10579607", "species_10579602", "species_10579617" ], "products": [ "species_10579055", "species_10579002", "species_10579050", "species_10579478", "species_10579623", "species_10579060", "species_10579301", "species_10578963", "species_10579473" ], "modifiers": [], "additional_components": [ "DDB_G0283901", "DDB_G0269192", "Q54V94", "DDB_G0280529", "Q54XS9", "DDB_G0278769", "Q54LG7", "DDB_G0286645", "Q54WL8", "DDB_G0279559", "Q54N48", "DDB_G0285507", "Q54J73", "DDB_G0288259", "Q55E68", "DDB_G0269370", "Q54ZS8", "DDB_G0277371", "Q55BS1", "DDB_G0270392", "Q55CA3", "DDB_G0270148", "Q54PX4", "DDB_G0284319", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797", "C7G084", "DDB_G0295793", "Q54TS6", "DDB_G0281585", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "C7G054", "DDB_G0302414", 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"Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q54YA5", "DDB_G0278335", "Q55FQ0", "DDB_G0268004", "Q54J05", "DDB_G0288391", "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q54K20", "DDB_G0287635", "Q86J17", "DDB_G0274281", "Q8T2A7", "DDB_G0274213", "Q54ST0", "DDB_G0282243", "C7G068", "DDB_G0289595", "DDB_G0274361" ] }, "reaction_10579630": { "compartment": "compartment_7660", "id": "reaction_10579630", "reactome": "R-DDI-72139", "name": "Formation of the active Spliceosomal C (B*) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10579623" ], "products": [ "species_10579627", "species_10579617" ], "modifiers": [ [ "species_10579623", "catalyst" ] ], "additional_components": [ "Q54LT3", "DDB_G0286425", "Q54NS6", "DDB_G0285077", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55BF5", "DDB_G0271312", "Q86JC5", "DDB_G0275957", "Q1ZXF6", "DDB_G0284555", "Q54LY9", "DDB_G0286297", "Q54IV3", "DDB_G0288501", "Q54SA7", "DDB_G0282569", "Q54BG2", "DDB_G0293636", "Q54PP4", "DDB_G0284403", "Q54TL3", "DDB_G0281687", "Q55CI7", "DDB_G0271014", "Q54Q46", "DDB_G0284101", 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"DDB_G0279695", "Q555Z2", "DDB_G0274797", "DDB_G0268358", "Q54LT3", "DDB_G0286425", "Q54NS6", "DDB_G0285077", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55BF5", "DDB_G0271312", "Q86JC5", "DDB_G0275957", "Q1ZXF6", "DDB_G0284555", "Q54LY9", "DDB_G0286297", "Q54IV3", "DDB_G0288501", "Q54SA7", "DDB_G0282569", "Q54BG2", "DDB_G0293636", "Q54PP4", "DDB_G0284403", "Q54TL3", "DDB_G0281687", "Q55CI7", "DDB_G0271014", "Q54Q46", "DDB_G0284101", "Q54J05", "DDB_G0288391", "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", 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"DDB_G0291966", "Q54PX3", "DDB_G0291966", "Q54HF5", "DDB_G0289501", "Q54Z08", "DDB_G0277977", "Q55EC6", "DDB_G0269300", "Q55D61", "DDB_G0269192", "Q54V94", "DDB_G0280529", "Q54XS9", "DDB_G0278769", "Q54LG7", "DDB_G0286645", "Q54WL8", "DDB_G0279559", "Q54N48", "DDB_G0285507", "Q54J73", "DDB_G0288259", "Q55E68", "DDB_G0269370", "Q54ZS8", "DDB_G0277371", "Q55BS1", "DDB_G0270392", "Q55CA3", "DDB_G0270148", "Q54PX4", "DDB_G0284319", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797", "C7G084", "DDB_G0295793", "Q54TS6", "DDB_G0281585", "P54705", "DDB_G0269188", "Q86A78", "DDB_G0274577", "Q54FZ3", "DDB_G0290649", "Q54NB4", "DDB_G0285363", "Q54NB3", "DDB_G0285363", "Q9NI62", "DDB_G0269216", "Q54E37", "DDB_G0291836", "Q54YS7", "DDB_G0278105", "Q54VI2", "DDB_G0280393", "Q54CE0", "DDB_G0293168", "Q54PW8", "DDB_G0284321", "Q54WE9", "DDB_G0279695", "Q86I71", "DDB_G0279695", "Q55G43", "DDB_G0268358", "Q55G70", "DDB_G0267796", "Q555Z2", "DDB_G0274797" ] }, "reaction_10581544": { "compartment": "compartment_7660", "id": "reaction_10581544", "reactome": "R-DDI-75079", "name": "Formation of AT-AC C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581540" ], "products": [ "species_10581532", "species_10581542" ], "modifiers": [], "additional_components": [ "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q8T295", "DDB_G0274229", "Q54ST0", "DDB_G0282243", "Q553S5", "DDB_G0275407", "Q55A15", "DDB_G0272374", "Q54R72", "DDB_G0283359", "Q55AR8", "DDB_G0271788", "Q54TF6", "DDB_G0281779", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q1ZXB1", "DDB_G0291966", "Q54PX3", "DDB_G0291966", "Q55BF5", "DDB_G0271312", "Q86JC5", "DDB_G0275957", "Q1ZXF6", "DDB_G0284555", "Q54LY9", "DDB_G0286297", "Q54IV3", "DDB_G0288501", "Q54SA7", "DDB_G0282569", "Q55CC1", "DDB_G0270734", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q1ZXB1", "DDB_G0291966", "Q54PX3", "DDB_G0291966", "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q8T295", "DDB_G0274229", "Q54ST0", "DDB_G0282243", "Q553S5", "DDB_G0275407", "Q55A15", "DDB_G0272374", "Q54R72", "DDB_G0283359", "Q55AR8", "DDB_G0271788", "Q54TF6", "DDB_G0281779", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q55BF5", "DDB_G0271312", "Q86JC5", "DDB_G0275957", "Q1ZXF6", "DDB_G0284555", "Q54LY9", "DDB_G0286297", "Q54IV3", "DDB_G0288501", "Q54SA7", "DDB_G0282569", "Q55CC1", "DDB_G0270734", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10581546": { "compartment": "compartment_7660", "id": "reaction_10581546", "reactome": "R-DDI-75082", "name": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581542" ], "products": [ "species_10581542" ], "modifiers": [], "additional_components": [ "Q1ZXB1", "DDB_G0291966", "Q54PX3", "DDB_G0291966", "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q8T295", "DDB_G0274229", "Q54ST0", "DDB_G0282243", "Q553S5", "DDB_G0275407", "Q55A15", "DDB_G0272374", "Q54R72", "DDB_G0283359", "Q55AR8", "DDB_G0271788", "Q54TF6", "DDB_G0281779", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q55BF5", "DDB_G0271312", "Q86JC5", "DDB_G0275957", "Q1ZXF6", "DDB_G0284555", "Q54LY9", "DDB_G0286297", "Q54IV3", "DDB_G0288501", "Q54SA7", "DDB_G0282569", "Q55CC1", "DDB_G0270734", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q1ZXB1", "DDB_G0291966", "Q54PX3", "DDB_G0291966", "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q8T295", "DDB_G0274229", "Q54ST0", "DDB_G0282243", "Q553S5", "DDB_G0275407", "Q55A15", "DDB_G0272374", "Q54R72", "DDB_G0283359", "Q55AR8", "DDB_G0271788", "Q54TF6", "DDB_G0281779", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q55BF5", "DDB_G0271312", "Q86JC5", "DDB_G0275957", "Q1ZXF6", "DDB_G0284555", "Q54LY9", "DDB_G0286297", "Q54IV3", "DDB_G0288501", "Q54SA7", "DDB_G0282569", "Q55CC1", "DDB_G0270734", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10590100": { "compartment": "compartment_876", "id": "reaction_10590100", "reactome": "R-DDI-381608", "name": "cAMP activates EPAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10590096" ], "products": [ "species_10590098" ], "modifiers": [], "additional_components": [ "Q54TK8", "DDB_G0281573", "Q8IS12", "DDB_G0275703", "Q54TK8", "DDB_G0281573", "Q8IS12", "DDB_G0275703", "species_30389" ] }, "reaction_10590135": { "compartment": "compartment_876", "id": "reaction_10590135", "reactome": "R-DDI-381668", "name": "cAMP activates EPAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10590131" ], "products": [ "species_10590133" ], "modifiers": [], "additional_components": [ "Q8IS12", "DDB_G0275703", "Q54TK8", "DDB_G0281573", "Q8IS12", "DDB_G0275703", "Q54TK8", "DDB_G0281573", "species_30389" ] }, "reaction_10590141": { "compartment": "compartment_70101", "id": "reaction_10590141", "reactome": "R-DDI-381727", "name": "RAP1A exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10590137" ], "products": [ "species_29420", "species_10590139" ], "modifiers": [ [ "species_10590133", "catalyst" ], [ "species_10590098", "catalyst" ] ], "additional_components": [ "species_29420", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "species_29438", "Q8IS12", "DDB_G0275703", "Q54TK8", "DDB_G0281573", "species_30389", "Q54TK8", "DDB_G0281573", "Q8IS12", "DDB_G0275703", "species_30389" ] }, "reaction_10590124": { "compartment": "compartment_12045", "id": "reaction_10590124", "reactome": "R-DDI-381644", "name": "ER calcium channels open in response to activated PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590114" ], "products": [ "species_10590122" ], "modifiers": [ [ "species_10582991", "catalyst" ] ], "additional_components": [ "Q9NA13", "DDB_G0292564", "Q9NA13", "DDB_G0292564", "species_114520", "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029" ] }, "reaction_10586788": { "compartment": "compartment_70101", "id": "reaction_10586788", "reactome": "R-DDI-196402", "name": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_195655", "species_29364" ], "products": [ "species_29366", "species_196420" ], "modifiers": [ [ "species_10586785", "catalyst" ] ], "additional_components": [ "DDB_G0284407" ] }, "reaction_10586760": { "compartment": "compartment_12045", "id": "reaction_10586760", "reactome": "R-DDI-195690", "name": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194691" ], "products": [ "species_195691" ], "modifiers": [ [ "species_10586757", "catalyst" ] ], "additional_components": [ "DDB_G0269414" ] }, "reaction_10627239": { "compartment": "compartment_984", "id": "reaction_10627239", "reactome": "R-DDI-9673054", "name": "PM20D1 hydrolyzes oleoyl-phe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_9673044" ], "products": [ "species_351993", "species_9673048" ], "modifiers": [ [ "species_10627234", "catalyst" ] ], "additional_components": [ "DDB_G0270582" ] }, "reaction_10627237": { "compartment": "compartment_984", "id": "reaction_10627237", "reactome": "R-DDI-9673053", "name": "PM20D1 transforms oleoyl-phe from oleate and phe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351993", "species_9673048" ], "products": [ "species_109276", "species_9673044" ], "modifiers": [ [ "species_10627234", "catalyst" ] ], "additional_components": [ "DDB_G0270582" ] }, "reaction_10594189": { "compartment": "compartment_70101", "id": "reaction_10594189", "reactome": "R-DDI-874087", "name": "SGT1 binds HSP90", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594185", "species_10594183" ], "products": [ "species_10594187" ], "modifiers": [], "additional_components": [ "DDB_G0267400", "DDB_G0269292", "Q55ED0", "DDB_G0269292", "P54651", "DDB_G0267400" ] }, "reaction_10590742": { "compartment": "compartment_876", "id": "reaction_10590742", "reactome": "R-DDI-418309", "name": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016" ], "products": [ "species_74112" ], "modifiers": [ [ "species_10590739", "catalyst" ] ], "additional_components": [ "P54678", "DDB_G0277861", "Q54HG6", "DDB_G0289473", "Q54PE8", "DDB_G0289473" ] }, "reaction_10613009": { "compartment": "compartment_7660", "id": "reaction_10613009", "reactome": "R-DDI-6791219", "name": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612993" ], "products": [ "species_10612972" ], "modifiers": [ [ "species_10612963", "catalyst" ], [ "species_10612968", "catalyst" ], [ "species_10613007", "catalyst" ], [ "species_10612991", "catalyst" ] ], "additional_components": [ "Q75JW2", "DDB_G0272176", "Q54Z27", "DDB_G0277945", "Q54DG4", "DDB_G0292290", "Q54W97", "DDB_G0279809", "Q55DQ9", "DDB_G0270828", "Q54IM3", "DDB_G0288659", "Q54TD8", "DDB_G0281839", "Q54HJ2", "DDB_G0289415", "Q54W52", "DDB_G0279903", "Q75JW2", "DDB_G0272176", "Q54Z27", "DDB_G0277945", "Q54DG4", "DDB_G0292290", "Q54W97", "DDB_G0279809", "Q55DQ9", "DDB_G0270828", "Q54IM3", "DDB_G0288659", "DDB_G0272176", "DDB_G0277945", "Q54P34", "DDB_G0284817", "Q54HJ2", "DDB_G0289415", "Q54KS4", "DDB_G0287147", "Q54TD8", "DDB_G0281839", "Q54HJ2", "DDB_G0289415", "Q54W52", "DDB_G0279903" ] }, "reaction_10613443": { "compartment": "compartment_70101", "id": "reaction_10613443", "reactome": "R-DDI-6791223", "name": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613417", "species_10613415" ], "products": [ "species_10613423", "species_10613421", "species_10613435", "species_10613419", "species_10613433", "species_10613417", "species_10579913", "species_10613431", "species_10613429", "species_10613427", "species_10613425" ], "modifiers": [ [ "species_10613423", "catalyst" ], [ "species_10613433", "catalyst" ], [ "species_10613441", "catalyst" ], [ "species_10613435", "catalyst" ] ], "additional_components": [ "DDB_G0280431", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "P90526", "DDB_G0293000", "P14132", "DDB_G0289877", "Q76P36", "DDB_G0272308", "Q54U04", "DDB_G0281409", "Q54I41", "DDB_G0289025", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "Q54UU3", "DDB_G0280823", "Q54GC0", "DDB_G0290281", "P27685", "DDB_G0293742", "Q556Y4", "DDB_G0273059", "Q54TL8", "DDB_G0281677", "Q03409", "DDB_G0271148", "Q54VD8", "DDB_G0280431", "Q54BN4", "DDB_G0293700", "Q54YA7", "DDB_G0278331", "Q54Y41", "DDB_G0278429", "Q54X51", "DDB_G0279207", "Q869U7", "DDB_G0276415", "P42520", "DDB_G0290141", "Q54T05", "DDB_G0282099", "Q54N17", "DDB_G0285561", "Q54K66", "DDB_G0287557", "Q54PX9", "DDB_G0284237", "O77082", "DDB_G0286117", "Q54E24", "DDB_G0291864", "Q54MA6", "DDB_G0286075", "Q54W91", "DDB_G0279821", "Q54ZW5", "DDB_G0277345", "Q75K27", "DDB_G0275473", "Q8T1D4", "DDB_G0275601", "Q8T1V4", "DDB_G0277635", "Q54MZ5", "DDB_G0285597", "Q55A19", "DDB_G0272250", "Q54Q51", "DDB_G0284093", "P46793", "DDB_G0276457", "Q54IS0", "DDB_G0288565", "Q54PH8", "DDB_G0284533", "Q54S90", "DDB_G0282601", "Q54W23", "DDB_G0279961", "P51405", "DDB_G0272825", "Q3ZE13", "DDB_G0269980", "DDB_G0279821", "DDB_G0275601", "DDB_G0273059", "DDB_G0288565", "DDB_G0273059", "DDB_G0280431", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "DDB_G0280431", "DDB_G0278331", "DDB_G0282099", "DDB_G0287557", "DDB_G0279821", "DDB_G0273059", "DDB_G0269722", "DDB_G0273059" ] }, "reaction_10613285": { "compartment": "compartment_7660", "id": "reaction_10613285", "reactome": "R-DDI-6791222", "name": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613233" ], "products": [ "species_10613241" ], "modifiers": [ [ "species_10613282", "catalyst" ], [ "species_10613246", "catalyst" ], [ "species_10613265", "catalyst" ], [ "species_10613280", "catalyst" ] ], "additional_components": [ "Q54JS8", "DDB_G0287891", "Q54S38", "DDB_G0282803", "Q553S0", "DDB_G0275403", "Q54WV7", "DDB_G0279371", "Q55GM5", "DDB_G0267606", "Q54HT2", "DDB_G0289235", "Q54X28", "DDB_G0279245", "Q54XG2", "DDB_G0278983", "C7G018", "DDB_G0302418", "Q54KG8", "DDB_G0287351", "Q7KWM6", "DDB_G0272732", "Q55BA1", "DDB_G0271240", "Q54PE0", "DDB_G0284621", "Q54WN5", "DDB_G0279601", "Q550V0", "DDB_G0277019", "Q54S79", "DDB_G0282623", "Q7KWS8", "DDB_G0276283", "Q54UU6", "DDB_G0280805", "Q86IZ9", "DDB_G0274325", "Q54BV0", "DDB_G0293412", "Q54ST0", "DDB_G0282243", "Q55CW0", "DDB_G0269878", "Q55FI4", "DDB_G0268098", "Q54MT2", "DDB_G0285679", "Q54VT4", "DDB_G0280147", "Q54EN2", "DDB_G0291438", "Q54XT8", "DDB_G0278751", "Q55D06", "DDB_G0269830", "Q54GG4", "DDB_G0290181", "Q54K79", "DDB_G0287537", "Q7KWL3", "DDB_G0276815", "P27685", "DDB_G0293742", "Q54VA5", "DDB_G0280489", "Q54UU3", "DDB_G0280823", "Q54I41", "DDB_G0289025", "P14132", "DDB_G0289877", "Q8T2Q3", "DDB_G0275141", "Q55EH5", "DDB_G0268898", "Q54QV4", "DDB_G0283581", "Q54ML4", "DDB_G0285875", "Q55C50", "DDB_G0270230", "Q54EG3", "DDB_G0291526", "Q54JS8", "DDB_G0287891", "Q54S38", "DDB_G0282803", "Q553S0", "DDB_G0275403", "Q54WV7", "DDB_G0279371", "Q55GM5", "DDB_G0267606", "Q54HT2", "DDB_G0289235", "Q54X28", "DDB_G0279245", "Q54XG2", "DDB_G0278983", "C7G018", "DDB_G0302418", "Q54KG8", "DDB_G0287351", "Q7KWM6", "DDB_G0272732", "Q55BA1", "DDB_G0271240", "Q54PE0", "DDB_G0284621", "Q54WN5", "DDB_G0279601", "Q550V0", "DDB_G0277019", "Q54S79", "DDB_G0282623", "Q7KWS8", "DDB_G0276283", "Q54UU6", "DDB_G0280805", "Q86IZ9", "DDB_G0274325", "Q54BV0", "DDB_G0293412", "Q54ST0", "DDB_G0282243", "Q55CW0", "DDB_G0269878", "Q55FI4", "DDB_G0268098", "Q54MT2", "DDB_G0285679", "Q54VT4", "DDB_G0280147", "Q54EN2", "DDB_G0291438", "Q54XT8", "DDB_G0278751", "Q55D06", "DDB_G0269830", "Q54GG4", "DDB_G0290181", "Q54K79", "DDB_G0287537", "Q7KWL3", "DDB_G0276815", "P27685", "DDB_G0293742", "Q54VA5", "DDB_G0280489", "Q54UU3", "DDB_G0280823", "Q54I41", "DDB_G0289025", "P14132", "DDB_G0289877", "Q8T2Q3", "DDB_G0275141", "Q55EH5", "DDB_G0268898", "Q54QV4", "DDB_G0283581", "Q54ML4", "DDB_G0285875", "Q55C50", "DDB_G0270230", "Q54EG3", "DDB_G0291526", "Q86IE2", "DDB_G0275633", "Q54ZS3", "DDB_G0277279", "Q55AW0", "DDB_G0271572", "Q54Q83", "DDB_G0284053", "Q55BB0", "DDB_G0271396", "Q54VM4", "DDB_G0280251", "Q54CU6", "DDB_G0292692", "Q54N99", "DDB_G0285377", "Q55BJ2", "DDB_G0271100", "Q54EV5", "DDB_G0291310", "Q7KWX9", "DDB_G0276783", "Q54EU6", "DDB_G0291328", "DDB_G0271572", "DDB_G0284053", "DDB_G0275633" ] }, "reaction_10613464": { "compartment": "compartment_7660", "id": "reaction_10613464", "reactome": "R-DDI-6791227", "name": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613450" ], "products": [ "species_10613454" ], "modifiers": [ [ "species_10613459", "catalyst" ], [ "species_10613107", "catalyst" ], [ "species_10613131", "catalyst" ], [ "species_10613462", "catalyst" ], [ "species_10613085", "catalyst" ], [ "species_10613280", "catalyst" ] ], "additional_components": [ "Q54JS8", "DDB_G0287891", "Q54S38", "DDB_G0282803", "Q553S0", "DDB_G0275403", "Q54WV7", "DDB_G0279371", "Q55GM5", "DDB_G0267606", "Q54HT2", "DDB_G0289235", "Q54X28", "DDB_G0279245", "Q54XG2", "DDB_G0278983", "C7G018", "DDB_G0302418", "Q54KG8", "DDB_G0287351", "Q7KWM6", "DDB_G0272732", "Q55BA1", "DDB_G0271240", "Q54PE0", "DDB_G0284621", "Q54WN5", "DDB_G0279601", "Q550V0", "DDB_G0277019", "Q54S79", "DDB_G0282623", "Q7KWS8", "DDB_G0276283", "Q54UU6", "DDB_G0280805", "Q86IZ9", "DDB_G0274325", "Q54BV0", "DDB_G0293412", "Q54ST0", "DDB_G0282243", "Q55CW0", "DDB_G0269878", "Q55FI4", "DDB_G0268098", "Q54MT2", "DDB_G0285679", "Q54VT4", "DDB_G0280147", "Q54EN2", "DDB_G0291438", "Q54XT8", "DDB_G0278751", "Q55D06", "DDB_G0269830", "Q54GG4", "DDB_G0290181", "Q54K79", "DDB_G0287537", "Q7KWL3", "DDB_G0276815", "P27685", "DDB_G0293742", "Q54VA5", "DDB_G0280489", "Q54UU3", "DDB_G0280823", "Q54I41", "DDB_G0289025", "P14132", "DDB_G0289877", "Q8T2Q3", "DDB_G0275141", "Q55EH5", "DDB_G0268898", "Q54QV4", "DDB_G0283581", "Q54ML4", "DDB_G0285875", "Q55C50", "DDB_G0270230", "Q54EG3", "DDB_G0291526", "Q54JS8", "DDB_G0287891", "Q54S38", "DDB_G0282803", "Q553S0", "DDB_G0275403", "Q54WV7", "DDB_G0279371", "Q55GM5", "DDB_G0267606", "Q54HT2", "DDB_G0289235", "Q54X28", "DDB_G0279245", "Q54XG2", "DDB_G0278983", "C7G018", "DDB_G0302418", "Q54KG8", "DDB_G0287351", "Q7KWM6", "DDB_G0272732", "Q55BA1", "DDB_G0271240", "Q54PE0", "DDB_G0284621", "Q54WN5", "DDB_G0279601", "Q550V0", "DDB_G0277019", "Q54S79", "DDB_G0282623", "Q7KWS8", "DDB_G0276283", "Q54UU6", "DDB_G0280805", "Q86IZ9", "DDB_G0274325", "Q54BV0", "DDB_G0293412", "Q54ST0", "DDB_G0282243", "Q55CW0", "DDB_G0269878", "Q55FI4", "DDB_G0268098", "Q54MT2", "DDB_G0285679", "Q54VT4", "DDB_G0280147", "Q54EN2", "DDB_G0291438", "Q54XT8", "DDB_G0278751", "Q55D06", "DDB_G0269830", "Q54GG4", "DDB_G0290181", "Q54K79", "DDB_G0287537", "Q7KWL3", "DDB_G0276815", "P27685", "DDB_G0293742", "Q54VA5", "DDB_G0280489", "Q54UU3", "DDB_G0280823", "Q54I41", "DDB_G0289025", "P14132", "DDB_G0289877", "Q8T2Q3", "DDB_G0275141", "Q55EH5", "DDB_G0268898", "Q54QV4", "DDB_G0283581", "Q54ML4", "DDB_G0285875", "Q55C50", "DDB_G0270230", "Q54EG3", "DDB_G0291526", "DDB_G0269922", "DDB_G0271240", "Q54EN2", "DDB_G0291438", "Q54XT8", "DDB_G0278751", "Q55D06", "DDB_G0269830", "DDB_G0291836", "Q8T2Q3", "DDB_G0275141", "Q55EH5", "DDB_G0268898", "Q54QV4", "DDB_G0283581", "Q54ML4", "DDB_G0285875", "DDB_G0275633" ] }, "reaction_10590291": { "compartment": "compartment_17951", "id": "reaction_10590291", "reactome": "R-DDI-389550", "name": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389548", "species_389556" ], "products": [ "species_193465", "species_389536", "species_389537", "species_113602" ], "modifiers": [ [ "species_10590288", "catalyst" ] ], "additional_components": [ "Q75JR2", "DDB_G0272210" ] }, "reaction_10617763": { "compartment": "compartment_70101", "id": "reaction_10617763", "reactome": "R-DDI-6811504", "name": "AKT1 dephosphorylation by PP2A-B56-beta,gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10586949" ], "products": [ "species_10590479", "species_29372" ], "modifiers": [ [ "species_10617760", "catalyst" ], [ "species_1806240", "inhibitor" ] ], "additional_components": [ "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "Q54VB6", "DDB_G0280469" ] }, "reaction_10598646": { "compartment": "compartment_876", "id": "reaction_10598646", "reactome": "R-DDI-1675776", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806240", "species_113592" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10598643", "catalyst" ] ], "additional_components": [ "Q86D86", "DDB_G0283615", "Q54DL4", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635" ] }, "reaction_10599019": { "compartment": "compartment_876", "id": "reaction_10599019", "reactome": "R-DDI-1676082", "name": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10598592", "catalyst" ] ], "additional_components": [ "Q54M96", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635", "Q54VR4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q86D86", "DDB_G0283615", "Q54DL4", "DDB_G0292190" ] }, "reaction_10611344": { "compartment": "compartment_7660", "id": "reaction_10611344", "reactome": "R-DDI-5693533", "name": "DCLRE1C (ARTEMIS) processes DNA DSB ends", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608592" ], "products": [ "species_10611341" ], "modifiers": [ [ "species_10608592", "catalyst" ] ], "additional_components": [ "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303" ] }, "reaction_10611360": { "compartment": "compartment_7660", "id": "reaction_10611360", "reactome": "R-DDI-5693574", "name": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611358", "species_10608604", "species_10608613", "species_10608611" ], "products": [ "species_10608617" ], "modifiers": [], "additional_components": [ "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54CR9", "DDB_G0292760", "Q54YJ7", "DDB_G0278203", "DDB_G0284713", "Q54P54", "DDB_G0284785", "Q54P54", "DDB_G0284785", "Q1ZXF2", "DDB_G0284713", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54CR9", "DDB_G0292760", "Q54YJ7", "DDB_G0278203" ] }, "reaction_10608595": { "compartment": "compartment_7660", "id": "reaction_10608595", "reactome": "R-DDI-5687183", "name": "PRKDC phosphorylates DCLRE1C at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10608588" ], "products": [ "species_113582", "species_10608592" ], "modifiers": [ [ "species_10608588", "catalyst" ] ], "additional_components": [ "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303" ] }, "reaction_10611369": { "compartment": "compartment_7660", "id": "reaction_10611369", "reactome": "R-DDI-5693575", "name": "DNA-PKcs autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611366" ], "products": [ "species_113582", "species_10608586" ], "modifiers": [ [ "species_10611366", "catalyst" ] ], "additional_components": [ "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303" ] }, "reaction_10611384": { "compartment": "compartment_7660", "id": "reaction_10611384", "reactome": "R-DDI-5693578", "name": "TDP1 and TDP2 process unligatable DSB ends", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611341" ], "products": [ "species_10611358" ], "modifiers": [ [ "species_10611381", "catalyst" ] ], "additional_components": [ "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303" ] }, "reaction_10611390": { "compartment": "compartment_7660", "id": "reaction_10611390", "reactome": "R-DDI-5693615", "name": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611388", "species_10611362" ], "products": [ "species_10611366" ], "modifiers": [], "additional_components": [ "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "DDB_G0281167", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303" ] }, "reaction_10608622": { "compartment": "compartment_7660", "id": "reaction_10608622", "reactome": "R-DDI-5687360", "name": "POLL or POLM extends aligned DNA DSB ends to fill gaps", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10608617" ], "products": [ "species_10608619", "species_113541" ], "modifiers": [ [ "species_10608617", "catalyst" ] ], "additional_components": [ "Q54P54", "DDB_G0284785", "Q1ZXF2", "DDB_G0284713", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54CR9", "DDB_G0292760", "Q54YJ7", "DDB_G0278203", "Q54P54", "DDB_G0284785", "Q1ZXF2", "DDB_G0284713", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54CR9", "DDB_G0292760", "Q54YJ7", "DDB_G0278203", "Q54P54", "DDB_G0284785", "Q1ZXF2", "DDB_G0284713", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54CR9", "DDB_G0292760", "Q54YJ7", "DDB_G0278203" ] }, "reaction_10599936": { "compartment": "compartment_70101", "id": "reaction_10599936", "reactome": "R-DDI-2029456", "name": "RAC1 and CDC42 activate PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590366", "species_10583374" ], "products": [ "species_10590364", "species_10599932" ], "modifiers": [], "additional_components": [ "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "P34144", "DDB_G0277869", "species_29438", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10600039": { "compartment": "compartment_70101", "id": "reaction_10600039", "reactome": "R-DDI-2029473", "name": "Branching and elongation of mother and daughter filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600037", "species_10587698" ], "products": [ "species_10599621" ], "modifiers": [], "additional_components": [ "O96626", "DDB_G0288319", "O96622", "DDB_G0277825", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54L54", "DDB_G0286893", "species_29370", "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54L54", "DDB_G0286893", "species_113592", "O96626", "DDB_G0288319", "O96622", "DDB_G0277825", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54L54", "DDB_G0286893" ] }, "reaction_10599993": { "compartment": "compartment_70101", "id": "reaction_10599993", "reactome": "R-DDI-2029466", "name": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599576", "species_10599989" ], "products": [ "species_10599991" ], "modifiers": [], "additional_components": [ "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54L54", "DDB_G0286893", "species_113592", "O96626", "DDB_G0288319", "O96622", "DDB_G0277825", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "species_179838", "Q869Q3", "DDB_G0274519", "Q55FT9", "DDB_G0267956", "Q54X65", "DDB_G0279175", "Q6UK63", "DDB_G0287855", "P34144", "DDB_G0277869", "species_29438", "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54L54", "DDB_G0286893", "O96626", "DDB_G0288319", "O96622", "DDB_G0277825", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "species_179838", "Q869Q3", "DDB_G0274519", "Q55FT9", "DDB_G0267956", "Q54X65", "DDB_G0279175", "Q6UK63", "DDB_G0287855", "P34144", "DDB_G0277869", "species_29438", "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54L54", "DDB_G0286893" ] }, "reaction_10600666": { "compartment": "compartment_70101", "id": "reaction_10600666", "reactome": "R-DDI-2197690", "name": "Detachment of WASP/WAVE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599991" ], "products": [ "species_10600037", "species_10599987" ], "modifiers": [], "additional_components": [ "O96626", "DDB_G0288319", "O96622", "DDB_G0277825", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "species_179838", "Q869Q3", "DDB_G0274519", "Q55FT9", "DDB_G0267956", "Q54X65", "DDB_G0279175", "Q6UK63", "DDB_G0287855", "P34144", "DDB_G0277869", "species_29438", "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54L54", "DDB_G0286893", "O96626", "DDB_G0288319", "O96622", "DDB_G0277825", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54L54", "DDB_G0286893", "species_29370", "species_179838", "Q869Q3", "DDB_G0274519", "Q55FT9", "DDB_G0267956", "Q54X65", "DDB_G0279175", "Q6UK63", "DDB_G0287855", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10599934": { "compartment": "compartment_70101", "id": "reaction_10599934", "reactome": "R-DDI-2029454", "name": "Autophosphorylation of PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599932", "species_113592" ], "products": [ "species_10583374", "species_29370", "species_10592613" ], "modifiers": [ [ "species_10590364", "catalyst" ] ], "additional_components": [ "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "P34144", "DDB_G0277869", "species_29438", "P34144", "DDB_G0277869", "species_29438", "Q869N2", "DDB_G0276459", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459" ] }, "reaction_10622818": { "compartment": "compartment_70101", "id": "reaction_10622818", "reactome": "R-DDI-8931974", "name": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583736", "species_71284" ], "products": [ "species_10622810", "species_71285" ], "modifiers": [ [ "species_10622815", "catalyst" ] ], "additional_components": [ "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "DDB_G0272708" ] }, "reaction_10622855": { "compartment": "compartment_70101", "id": "reaction_10622855", "reactome": "R-DDI-8932276", "name": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605038", "species_71284" ], "products": [ "species_10622843", "species_71285" ], "modifiers": [ [ "species_10622852", "catalyst" ] ], "additional_components": [ "DDB_G0288065", "DDB_G0288065", "Q54UI5", "DDB_G0288643", "Q54IN5", "DDB_G0288643" ] }, "reaction_10622829": { "compartment": "compartment_7660", "id": "reaction_10622829", "reactome": "R-DDI-8932221", "name": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10579254" ], "products": [ "species_77502", "species_10622821" ], "modifiers": [ [ "species_10622826", "catalyst" ] ], "additional_components": [ "DDB_G0269144", "DDB_G0269144", "DDB_G0288643" ] }, "reaction_10622877": { "compartment": "compartment_70101", "id": "reaction_10622877", "reactome": "R-DDI-8932413", "name": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583736", "species_71284" ], "products": [ "species_10622869", "species_71285" ], "modifiers": [ [ "species_10622874", "catalyst" ] ], "additional_components": [ "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "P0CT32", "DDB_G0269136", "P0CT31", "DDB_G0269134", "DDB_G0278427" ] }, "reaction_10588690": { "compartment": "compartment_70101", "id": "reaction_10588690", "reactome": "R-DDI-209845", "name": "CYP2R1 25-hydroxylates VD3 to 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_8963870", "species_29364" ], "products": [ "species_8963879", "species_29356", "species_29366" ], "modifiers": [ [ "species_10588687", "catalyst" ] ], "additional_components": [ "DDB_G0284535" ] }, "reaction_10586707": { "compartment": "compartment_70101", "id": "reaction_10586707", "reactome": "R-DDI-193800", "name": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193829", "species_29364" ], "products": [ "species_29366", "species_193843" ], "modifiers": [ [ "species_10586594", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586709": { "compartment": "compartment_70101", "id": "reaction_10586709", "reactome": "R-DDI-193816", "name": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_192194" ], "products": [ "species_70106", "species_193835", "species_73473" ], "modifiers": [ [ "species_10586611", "catalyst" ] ], "additional_components": [ "Q54XR1", "DDB_G0281487", "Q54TU9", "DDB_G0281487" ] }, "reaction_10586711": { "compartment": "compartment_70101", "id": "reaction_10586711", "reactome": "R-DDI-193821", "name": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_9617026" ], "products": [ "species_193829", "species_29366" ], "modifiers": [ [ "species_10586581", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586713": { "compartment": "compartment_70101", "id": "reaction_10586713", "reactome": "R-DDI-193824", "name": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193835", "species_29364" ], "products": [ "species_29366", "species_193830" ], "modifiers": [ [ "species_10586581", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586715": { "compartment": "compartment_70101", "id": "reaction_10586715", "reactome": "R-DDI-193841", "name": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193830" ], "products": [ "species_29366", "species_193842" ], "modifiers": [ [ "species_10586594", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586705": { "compartment": "compartment_70101", "id": "reaction_10586705", "reactome": "R-DDI-193789", "name": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192189", "species_29360" ], "products": [ "species_193724", "species_70106", "species_73473" ], "modifiers": [ [ "species_10586611", "catalyst" ] ], "additional_components": [ "Q54XR1", "DDB_G0281487", "Q54TU9", "DDB_G0281487" ] }, "reaction_10586697": { "compartment": "compartment_70101", "id": "reaction_10586697", "reactome": "R-DDI-193746", "name": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193724", "species_70106", "species_29364" ], "products": [ "species_29366", "species_193760" ], "modifiers": [ [ "species_10586581", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586699": { "compartment": "compartment_70101", "id": "reaction_10586699", "reactome": "R-DDI-193755", "name": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193745" ], "products": [ "species_193707", "species_29366" ], "modifiers": [ [ "species_10586581", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586701": { "compartment": "compartment_70101", "id": "reaction_10586701", "reactome": "R-DDI-193758", "name": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193760" ], "products": [ "species_29366", "species_213285" ], "modifiers": [ [ "species_10586594", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586703": { "compartment": "compartment_70101", "id": "reaction_10586703", "reactome": "R-DDI-193781", "name": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193707", "species_29364" ], "products": [ "species_29366", "species_193728" ], "modifiers": [ [ "species_10586594", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586688": { "compartment": "compartment_17951", "id": "reaction_10586688", "reactome": "R-DDI-193369", "name": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_193442" ], "products": [ "species_113575", "species_193459" ], "modifiers": [ [ "species_10586633", "catalyst" ] ], "additional_components": [ "species_113596", "Q54GQ6", "DDB_G0289993" ] }, "reaction_10586691": { "compartment": "compartment_17951", "id": "reaction_10586691", "reactome": "R-DDI-193455", "name": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193422", "species_192307" ], "products": [ "species_193465", "species_192305", "species_192339" ], "modifiers": [ [ "species_10586623", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10586626": { "compartment": "compartment_17951", "id": "reaction_10586626", "reactome": "R-DDI-192331", "name": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_192342" ], "products": [ "species_193422" ], "modifiers": [ [ "species_10586623", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10586597": { "compartment": "compartment_70101", "id": "reaction_10586597", "reactome": "R-DDI-192036", "name": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_192064" ], "products": [ "species_29366", "species_192087" ], "modifiers": [ [ "species_10586594", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586693": { "compartment": "compartment_17951", "id": "reaction_10586693", "reactome": "R-DDI-193508", "name": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193732", "species_192307" ], "products": [ "species_193465", "species_193403", "species_192305" ], "modifiers": [ [ "species_10586623", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10586599": { "compartment": "compartment_70101", "id": "reaction_10586599", "reactome": "R-DDI-192067", "name": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_192195" ], "products": [ "species_29366", "species_192064" ], "modifiers": [ [ "species_10586581", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586695": { "compartment": "compartment_17951", "id": "reaction_10586695", "reactome": "R-DDI-193535", "name": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_193459" ], "products": [ "species_193732" ], "modifiers": [ [ "species_10586623", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10586614": { "compartment": "compartment_70101", "id": "reaction_10586614", "reactome": "R-DDI-192097", "name": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_192114" ], "products": [ "species_70106", "species_192136", "species_73473" ], "modifiers": [ [ "species_10586611", "catalyst" ] ], "additional_components": [ "Q54XR1", "DDB_G0281487", "Q54TU9", "DDB_G0281487" ] }, "reaction_10586584": { "compartment": "compartment_70101", "id": "reaction_10586584", "reactome": "R-DDI-192033", "name": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_192136", "species_29364" ], "products": [ "species_191980", "species_29366" ], "modifiers": [ [ "species_10586581", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586616": { "compartment": "compartment_70101", "id": "reaction_10586616", "reactome": "R-DDI-192160", "name": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191980", "species_70106", "species_29364" ], "products": [ "species_192030", "species_29366" ], "modifiers": [ [ "species_10586594", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586636": { "compartment": "compartment_17951", "id": "reaction_10586636", "reactome": "R-DDI-192335", "name": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_192316" ], "products": [ "species_113575", "species_192342" ], "modifiers": [ [ "species_10586633", "catalyst" ] ], "additional_components": [ "species_113596", "Q54GQ6", "DDB_G0289993" ] }, "reaction_10586686": { "compartment": "compartment_876", "id": "reaction_10586686", "reactome": "R-DDI-193362", "name": "ABCB11 transports bile salts from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_193416", "species_113592" ], "products": [ "species_29372", "species_29370", "species_193479" ], "modifiers": [ [ "species_10586683", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:36274", "CHEBI:16525", "CHEBI:28865", "CHEBI:17687", "CHEBI:28865", "CHEBI:36274", "CHEBI:9407", "Q54BT3", "DDB_G0293438", "Q8T9W4", "DDB_G0291714" ] }, "reaction_10620155": { "compartment": "compartment_70101", "id": "reaction_10620155", "reactome": "R-DDI-8867667", "name": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8868399" ], "products": [ "species_8868400" ], "modifiers": [ [ "species_10620152", "catalyst" ] ], "additional_components": [ "Q54QP6", "DDB_G0283709", "Q8MPQ7", "DDB_G0280053", "Q86HL8", "DDB_G0274517", "Q54RM1", "DDB_G0283035", "Q54EF5", "DDB_G0291562", "Q86HV4", "DDB_G0276427", "Q55CR2", "DDB_G0269940", "Q55CR3", "DDB_G0269938", "Q54NM4", "DDB_G0285141", "Q86KG4", "DDB_G0272498", "Q54ID7", "DDB_G0288817" ] }, "reaction_10586559": { "compartment": "compartment_70101", "id": "reaction_10586559", "reactome": "R-DDI-191983", "name": "Cholesterol is hydroxylated to 25-hydroxycholesterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176478", "species_70106", "species_29368", "species_29364" ], "products": [ "species_29356", "species_192148", "species_29366" ], "modifiers": [ [ "species_10586556", "catalyst" ] ], "additional_components": [ "species_71067", "Q55D52", "DDB_G0279611", "Q55D54", "DDB_G0279611", "Q54WK0", "DDB_G0279611" ] }, "reaction_10586717": { "compartment": "compartment_70101", "id": "reaction_10586717", "reactome": "R-DDI-193961", "name": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196366" ], "products": [ "species_193092" ], "modifiers": [ [ "species_10586654", "catalyst" ] ], "additional_components": [ "Q54XR1", "DDB_G0281487", "Q54TU9", "DDB_G0281487" ] }, "reaction_10586780": { "compartment": "compartment_70101", "id": "reaction_10586780", "reactome": "R-DDI-196372", "name": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193124", "species_29360" ], "products": [ "species_196366", "species_70106", "species_73473" ], "modifiers": [ [ "species_10586654", "catalyst" ] ], "additional_components": [ "Q54XR1", "DDB_G0281487", "Q54TU9", "DDB_G0281487" ] }, "reaction_10586657": { "compartment": "compartment_70101", "id": "reaction_10586657", "reactome": "R-DDI-193052", "name": "Pregn-5-ene-3,20-dione isomerizes to progesterone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196344" ], "products": [ "species_193055" ], "modifiers": [ [ "species_10586654", "catalyst" ] ], "additional_components": [ "Q54XR1", "DDB_G0281487", "Q54TU9", "DDB_G0281487" ] }, "reaction_10586778": { "compartment": "compartment_70101", "id": "reaction_10586778", "reactome": "R-DDI-196350", "name": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193103", "species_29360" ], "products": [ "species_70106", "species_196344", "species_73473" ], "modifiers": [ [ "species_10586654", "catalyst" ] ], "additional_components": [ "Q54XR1", "DDB_G0281487", "Q54TU9", "DDB_G0281487" ] }, "reaction_10586775": { "compartment": "compartment_70101", "id": "reaction_10586775", "reactome": "R-DDI-196060", "name": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196095", "species_70106", "species_29364" ], "products": [ "species_29366", "species_196066" ], "modifiers": [ [ "species_10586772", "catalyst" ] ], "additional_components": [ "Q55FL3", "DDB_G0268058", "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562" ] }, "reaction_10627409": { "compartment": "compartment_70101", "id": "reaction_10627409", "reactome": "R-DDI-9705714", "name": "SRD5A3 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193057" ], "products": [ "species_469662", "species_29366" ], "modifiers": [ [ "species_10603671", "catalyst" ] ], "additional_components": [ "DDB_G0284423" ] }, "reaction_10586669": { "compartment": "compartment_70101", "id": "reaction_10586669", "reactome": "R-DDI-193064", "name": "HSD17B3-like proteins reducde ANDST to TEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193079", "species_29364" ], "products": [ "species_29366", "species_193057" ], "modifiers": [ [ "species_10586666", "catalyst" ] ], "additional_components": [ "Q869Y3", "DDB_G0275049" ] }, "reaction_10586671": { "compartment": "compartment_70101", "id": "reaction_10586671", "reactome": "R-DDI-193073", "name": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176626", "species_29360" ], "products": [ "species_70106", "species_193079", "species_73473" ], "modifiers": [ [ "species_10586654", "catalyst" ] ], "additional_components": [ "Q54XR1", "DDB_G0281487", "Q54TU9", "DDB_G0281487" ] }, "reaction_10594144": { "compartment": "compartment_70101", "id": "reaction_10594144", "reactome": "R-DDI-804969", "name": "HSD17B1 hydrogenates E1 to EST17b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193066", "species_29364" ], "products": [ "species_193132", "species_29366" ], "modifiers": [ [ "species_10594141", "catalyst" ] ], "additional_components": [ "Q556S5", "DDB_G0273855" ] }, "reaction_10612176": { "compartment": "compartment_5460", "id": "reaction_10612176", "reactome": "R-DDI-5696822", "name": "AKR1B15 reduces EST17b to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_5696835" ], "products": [ "species_113529", "species_5696848", "species_113600" ], "modifiers": [ [ "species_10612173", "catalyst" ] ], "additional_components": [ "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058", "Q6IMN8", "DDB_G0293850" ] }, "reaction_10586465": { "compartment": "compartment_70101", "id": "reaction_10586465", "reactome": "R-DDI-191402", "name": "Reduction of presqualene diphosphate to form squalene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_191265" ], "products": [ "species_111294", "species_191269", "species_29366" ], "modifiers": [ [ "species_10586462", "catalyst" ] ], "additional_components": [ "species_29926", "Q54DR1", "DDB_G0292072" ] }, "reaction_10586752": { "compartment": "compartment_70101", "id": "reaction_10586752", "reactome": "R-DDI-194718", "name": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194657", "species_29360" ], "products": [ "species_70106", "species_113528", "species_194661", "species_73473" ], "modifiers": [ [ "species_10586724", "catalyst" ] ], "additional_components": [ "DDB_G0281487" ] }, "reaction_10586467": { "compartment": "compartment_70101", "id": "reaction_10586467", "reactome": "R-DDI-191405", "name": "Two FPP molecules dimerize to form presqualene diphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191385" ], "products": [ "species_111294", "species_191265" ], "modifiers": [ [ "species_10586462", "catalyst" ] ], "additional_components": [ "species_29926", "Q54DR1", "DDB_G0292072" ] }, "reaction_10586435": { "compartment": "compartment_70101", "id": "reaction_10586435", "reactome": "R-DDI-191366", "name": "Squalene 2,3-epoxide cyclizes, forming lanosterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191309" ], "products": [ "species_194634" ], "modifiers": [ [ "species_10586432", "catalyst" ] ], "additional_components": [ "DDB_G0269226" ] }, "reaction_10586722": { "compartment": "compartment_70101", "id": "reaction_10586722", "reactome": "R-DDI-194641", "name": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_194644", "species_29364" ], "products": [ "species_194735", "species_29356", "species_29366" ], "modifiers": [ [ "species_10586719", "catalyst" ] ], "additional_components": [ "DDB_G0279611" ] }, "reaction_10586727": { "compartment": "compartment_70101", "id": "reaction_10586727", "reactome": "R-DDI-194642", "name": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194735", "species_29360" ], "products": [ "species_70106", "species_113528", "species_194667", "species_73473" ], "modifiers": [ [ "species_10586724", "catalyst" ] ], "additional_components": [ "DDB_G0281487" ] }, "reaction_10586409": { "compartment": "compartment_70101", "id": "reaction_10586409", "reactome": "R-DDI-191303", "name": "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191409", "species_191362" ], "products": [ "species_111294", "species_191385" ], "modifiers": [ [ "species_10586406", "catalyst" ] ], "additional_components": [ "Q54BK1", "DDB_G0293588", "species_29926", "Q9NH03", "DDB_G0278735" ] }, "reaction_10586729": { "compartment": "compartment_70101", "id": "reaction_10586729", "reactome": "R-DDI-194669", "name": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_194723" ], "products": [ "species_29356", "species_29366", "species_194657" ], "modifiers": [ [ "species_10586719", "catalyst" ] ], "additional_components": [ "DDB_G0279611" ] }, "reaction_10586445": { "compartment": "compartment_70101", "id": "reaction_10586445", "reactome": "R-DDI-191380", "name": "Mevalonate is phosphorylated to mevalonate-5-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191424" ], "products": [ "species_29370", "species_191296" ], "modifiers": [ [ "species_10586442", "catalyst" ] ], "additional_components": [ "Q86AG7", "DDB_G0272018" ] }, "reaction_10586477": { "compartment": "compartment_70101", "id": "reaction_10586477", "reactome": "R-DDI-191414", "name": "MVD decarboxylates MVA5PP to IPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191403" ], "products": [ "species_29372", "species_29370", "species_113528", "species_191362" ], "modifiers": [ [ "species_10586474", "catalyst" ] ], "additional_components": [ "Q54YQ9", "DDB_G0278607" ] }, "reaction_10586412": { "compartment": "compartment_70101", "id": "reaction_10586412", "reactome": "R-DDI-191322", "name": "Addition of isopentenyl pyrophosphate to DMAPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191324", "species_191362" ], "products": [ "species_111294", "species_191409" ], "modifiers": [ [ "species_10586406", "catalyst" ] ], "additional_components": [ "Q54BK1", "DDB_G0293588", "species_29926", "Q9NH03", "DDB_G0278735" ] }, "reaction_10623693": { "compartment": "compartment_70101", "id": "reaction_10623693", "reactome": "R-DDI-8952137", "name": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_191265" ], "products": [ "species_8952135", "species_29372" ], "modifiers": [ [ "species_10623690", "catalyst" ] ], "additional_components": [ "DDB_G0281069" ] }, "reaction_10586417": { "compartment": "compartment_70101", "id": "reaction_10586417", "reactome": "R-DDI-191323", "name": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191293", "species_76183" ], "products": [ "species_29356", "species_191374", "species_76194" ], "modifiers": [ [ "species_10586414", "catalyst" ] ], "additional_components": [ "DDB_G0274871" ] }, "reaction_10586737": { "compartment": "compartment_13231", "id": "reaction_10586737", "reactome": "R-DDI-194674", "name": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194681", "species_194725", "species_194688" ], "products": [ "species_194668", "species_194704" ], "modifiers": [ [ "species_10586734", "catalyst" ] ], "additional_components": [ "DDB_G0267448" ] }, "reaction_10586386": { "compartment": "compartment_70101", "id": "reaction_10586386", "reactome": "R-DDI-191299", "name": "Squalene is oxidized to its epoxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_191269", "species_29364" ], "products": [ "species_191309", "species_29356", "species_29366" ], "modifiers": [ [ "species_10586383", "catalyst" ] ], "additional_components": [ "species_113596", "Q54BK7", "DDB_G0293584" ] }, "reaction_10586455": { "compartment": "compartment_70101", "id": "reaction_10586455", "reactome": "R-DDI-191382", "name": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362" ], "products": [ "species_191324" ], "modifiers": [ [ "species_10586452", "catalyst" ] ], "additional_components": [ "Q9NH02", "DDB_G0290011", "species_29926" ] }, "reaction_10586745": { "compartment": "compartment_70101", "id": "reaction_10586745", "reactome": "R-DDI-194678", "name": "CYP51A1 demethylates LNSOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_194634", "species_29364" ], "products": [ "species_29356", "species_29366", "species_194644", "species_29460" ], "modifiers": [ [ "species_10586742", "catalyst" ] ], "additional_components": [ "DDB_G0279403" ] }, "reaction_10586427": { "compartment": "compartment_70101", "id": "reaction_10586427", "reactome": "R-DDI-191352", "name": "HMGCR dimer reduces bHMG-CoA to MVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191374", "species_70106", "species_29364" ], "products": [ "species_29366", "species_76194", "species_191424" ], "modifiers": [ [ "species_10586424", "catalyst" ] ], "additional_components": [ "P34135", "DDB_G0269142" ] }, "reaction_10616679": { "compartment": "compartment_12045", "id": "reaction_10616679", "reactome": "R-DDI-6807052", "name": "EBP isomerizes ZYMSTNL to LTHSOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6807048" ], "products": [ "species_6807054" ], "modifiers": [ [ "species_10586757", "catalyst" ] ], "additional_components": [ "DDB_G0269414" ] }, "reaction_10616681": { "compartment": "compartment_12045", "id": "reaction_10616681", "reactome": "R-DDI-6807055", "name": "DHCR7 reduces 7-dehydroCHOL to CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_6807057", "species_29364" ], "products": [ "species_193384", "species_29366" ], "modifiers": [ [ "species_10586785", "catalyst" ] ], "additional_components": [ "DDB_G0284407" ] }, "reaction_10604925": { "compartment": "compartment_17957", "id": "reaction_10604925", "reactome": "R-DDI-5250531", "name": "ARV1 transports CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193384" ], "products": [ "species_171095" ], "modifiers": [ [ "species_10604922", "catalyst" ] ], "additional_components": [ "DDB_G0290221" ] }, "reaction_10586750": { "compartment": "compartment_70101", "id": "reaction_10586750", "reactome": "R-DDI-194698", "name": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_194644", "species_29364" ], "products": [ "species_194633", "species_29366" ], "modifiers": [ [ "species_10586747", "catalyst" ] ], "additional_components": [ "DDB_G0267448" ] }, "reaction_10580109": { "compartment": "compartment_70101", "id": "reaction_10580109", "reactome": "R-DDI-72670", "name": "Formation of eIF2:GDP:eIF2B intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580105", "species_10580049" ], "products": [ "species_10580107" ], "modifiers": [], "additional_components": [ "Q54I81", "DDB_G0288961", "Q54RF3", "DDB_G0283163", "Q54FQ8", "DDB_G0290693", "Q54EY2", "DDB_G0291271", "Q54FM3", "DDB_G0290759", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29420", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "Q54I81", "DDB_G0288961", "Q54RF3", "DDB_G0283163", "Q54FQ8", "DDB_G0290693", "Q54EY2", "DDB_G0291271", "Q54FM3", "DDB_G0290759", "species_29420" ] }, "reaction_10580399": { "compartment": "compartment_70101", "id": "reaction_10580399", "reactome": "R-DDI-72722", "name": "eIF2 activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10580107" ], "products": [ "species_29420", "species_10580105", "species_10580004" ], "modifiers": [ [ "species_10580105", "catalyst" ] ], "additional_components": [ "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "Q54I81", "DDB_G0288961", "Q54RF3", "DDB_G0283163", "Q54FQ8", "DDB_G0290693", "Q54EY2", "DDB_G0291271", "Q54FM3", "DDB_G0290759", "species_29420", "Q54I81", "DDB_G0288961", "Q54RF3", "DDB_G0283163", "Q54FQ8", "DDB_G0290693", "Q54EY2", "DDB_G0291271", "Q54FM3", "DDB_G0290759", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54I81", "DDB_G0288961", "Q54RF3", "DDB_G0283163", "Q54FQ8", "DDB_G0290693", "Q54EY2", "DDB_G0291271", "Q54FM3", "DDB_G0290759" ] }, "reaction_10616599": { "compartment": "compartment_7660", "id": "reaction_10616599", "reactome": "R-DDI-6805061", "name": "CK2 binds FACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583211", "species_10616595" ], "products": [ "species_10616597" ], "modifiers": [], "additional_components": [ "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q54PF1", "DDB_G0284601", "Q02720", "DDB_G0276885", "Q54LR6", "DDB_G0286481", "Q54PF1", "DDB_G0284601", "Q02720", "DDB_G0276885", "Q54LR6", "DDB_G0286481", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677" ] }, "reaction_10603956": { "compartment": "compartment_7660", "id": "reaction_10603956", "reactome": "R-DDI-4570489", "name": "SUMOylation of NOP58 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601786", "species_10603928" ], "products": [ "species_10601725", "species_10603953" ], "modifiers": [ [ "species_10601786", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q54SX2", "DDB_G0282161", "DDB_G0268098", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "DDB_G0268098", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q54SX2", "DDB_G0282161" ] }, "reaction_10603944": { "compartment": "compartment_7660", "id": "reaction_10603944", "reactome": "R-DDI-4570467", "name": "SUMOylation of NOP58 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10603928" ], "products": [ "species_10601725", "species_10603942" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0268098", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q55FI4", "DDB_G0268098", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10583553": { "compartment": "compartment_114521", "id": "reaction_10583553", "reactome": "R-DDI-139854", "name": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_139827" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10583550", "catalyst" ] ], "additional_components": [ "species_114520", "species_74112", "Q9NA13", "DDB_G0292564" ] }, "reaction_10598400": { "compartment": "compartment_161320", "id": "reaction_10598400", "reactome": "R-DDI-1605736", "name": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605716", "species_1605715" ], "products": [ "species_1605637", "species_1605601" ], "modifiers": [ [ "species_10598397", "catalyst" ] ], "additional_components": [ "Q54EG4", "DDB_G0291524", "Q55B10", "DDB_G0271490" ] }, "reaction_10598437": { "compartment": "compartment_876", "id": "reaction_10598437", "reactome": "R-DDI-1606583", "name": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429807" ], "products": [ "species_1606609", "species_1861754" ], "modifiers": [ [ "species_10598434", "catalyst" ] ], "additional_components": [] }, "reaction_10598343": { "compartment": "compartment_161320", "id": "reaction_10598343", "reactome": "R-DDI-1605624", "name": "Beta-galactosidase hydrolyses GM1 to GM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605677" ], "products": [ "species_1605637", "species_1605610" ], "modifiers": [ [ "species_10598338", "catalyst" ] ], "additional_components": [ "DDB_G0290217" ] }, "reaction_10598425": { "compartment": "compartment_876", "id": "reaction_10598425", "reactome": "R-DDI-1606273", "name": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429776" ], "products": [ "species_429807", "species_1610735" ], "modifiers": [ [ "species_10598422", "catalyst" ] ], "additional_components": [ "Q86IG2", "DDB_G0288017", "Q1ZXD9", "DDB_G0288017", "species_29926" ] }, "reaction_10598408": { "compartment": "compartment_161320", "id": "reaction_10598408", "reactome": "R-DDI-1605797", "name": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605713" ], "products": [ "species_1605750", "species_1605673" ], "modifiers": [ [ "species_10598405", "catalyst" ] ], "additional_components": [ "DDB_G0293210" ] }, "reaction_10598427": { "compartment": "compartment_161320", "id": "reaction_10598427", "reactome": "R-DDI-1606312", "name": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605601" ], "products": [ "species_1605637", "species_1605592" ], "modifiers": [ [ "species_10598338", "catalyst" ] ], "additional_components": [ "DDB_G0290217" ] }, "reaction_10599629": { "compartment": "compartment_876", "id": "reaction_10599629", "reactome": "R-DDI-1861788", "name": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1861782" ], "products": [ "species_429807", "species_70113" ], "modifiers": [ [ "species_10599626", "catalyst" ] ], "additional_components": [ "DDB_G0292446" ] }, "reaction_10598508": { "compartment": "compartment_876", "id": "reaction_10598508", "reactome": "R-DDI-1640164", "name": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429776" ], "products": [ "species_429807", "species_1610735" ], "modifiers": [ [ "species_10598505", "catalyst" ] ], "additional_components": [ "DDB_G0285897" ] }, "reaction_10598383": { "compartment": "compartment_161320", "id": "reaction_10598383", "reactome": "R-DDI-1605632", "name": "Both hexosaminidase A and B can cleave GalNAc from globoside", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605608" ], "products": [ "species_1605716", "species_1605658" ], "modifiers": [ [ "species_10598380", "catalyst" ] ], "additional_components": [ "Q54K55", "DDB_G0287597", "Q54SC9", "DDB_G0282539", "Q54K56", "DDB_G0287659", "Q54MU9", "DDB_G0285647", "P13723", "DDB_G0287033" ] }, "reaction_10605541": { "compartment": "compartment_876", "id": "reaction_10605541", "reactome": "R-DDI-5617178", "name": "ATP2B4 binds to NOS1, inhibiting it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590744", "species_10590737" ], "products": [ "species_10605539" ], "modifiers": [], "additional_components": [ "DDB_G0269912", "P54678", "DDB_G0277861", "Q54HG6", "DDB_G0289473", "Q54PE8", "DDB_G0289473", "P54678", "DDB_G0277861", "Q54HG6", "DDB_G0289473", "Q54PE8", "DDB_G0289473", "Q55CT1", "DDB_G0269912" ] }, "reaction_10595189": { "compartment": "compartment_876", "id": "reaction_10595189", "reactome": "R-DDI-936942", "name": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10595116", "species_10577037" ], "products": [ "species_10595186" ], "modifiers": [ [ "species_10595116", "catalyst" ] ], "additional_components": [ "Q54F79", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55A66", "DDB_G0293202", "P11467", "DDB_G0290961", "Q55GA0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54FD5", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "P11467", "DDB_G0290961", "Q86L54", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "Q54F79", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55A66", "DDB_G0293202", "P11467", "DDB_G0290961", "Q55GA0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54LU8", "DDB_G0286465" ] }, "reaction_10595191": { "compartment": "compartment_70101", "id": "reaction_10595191", "reactome": "R-DDI-936963", "name": "IRAK2 induces TRAF6 oligomerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10595114", "species_10584497" ], "products": [ "species_10595116" ], "modifiers": [], "additional_components": [ "Q54F79", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55A66", "DDB_G0293202", "P11467", "DDB_G0290961", "Q55GA0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55A66", "DDB_G0293202", "P11467", "DDB_G0290961", "Q55GA0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54LU8", "DDB_G0286465" ] }, "reaction_10595194": { "compartment": "compartment_70101", "id": "reaction_10595194", "reactome": "R-DDI-936986", "name": "Activated TRAF6 synthesizes unanchored polyubiquitin chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037" ], "products": [ "species_10584754" ], "modifiers": [ [ "species_10595186", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54FD5", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "P11467", "DDB_G0290961", "Q86L54", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54LU8", "DDB_G0286465" ] }, "reaction_10595760": { "compartment": "compartment_74700", "id": "reaction_10595760", "reactome": "R-DDI-975147", "name": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10595757", "species_10577037" ], "products": [ "species_10593152" ], "modifiers": [ [ "species_10595757", "catalyst" ] ], "additional_components": [ "Q55A66", "DDB_G0293202", "P11467", "DDB_G0290961", "Q55GA0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54C11", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "P11467", "DDB_G0290961", "Q86L54", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "Q55A66", "DDB_G0293202", "P11467", "DDB_G0290961", "Q55GA0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q54LU8", "DDB_G0286465" ] }, "reaction_10595762": { "compartment": "compartment_74700", "id": "reaction_10595762", "reactome": "R-DDI-975185", "name": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10595755", "species_10584497" ], "products": [ "species_10595757" ], "modifiers": [], "additional_components": [ "Q55A66", "DDB_G0293202", "P11467", "DDB_G0290961", "Q55GA0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q55A66", "DDB_G0293202", "P11467", "DDB_G0290961", "Q55GA0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q54LU8", "DDB_G0286465" ] }, "reaction_10584367": { "compartment": "compartment_984", "id": "reaction_10584367", "reactome": "R-DDI-166015", "name": "Association of LBP with LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584361", "species_166005" ], "products": [ "species_10584363" ], "modifiers": [ [ "species_10584365", "inhibitor" ] ], "additional_components": [ "Q54JE8", "DDB_G0288097", "Q55BA2", "DDB_G0271242", "Q54JE7", "DDB_G0288097", "species_166005", "Q54JE8", "DDB_G0288097", "Q55BA2", "DDB_G0271242", "Q54JE7", "DDB_G0288097", "DDB_G0271242" ] }, "reaction_10616640": { "compartment": "compartment_984", "id": "reaction_10616640", "reactome": "R-DDI-6805981", "name": "HMGB1 release from cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589181" ], "products": [ "species_10616549" ], "modifiers": [], "additional_components": [ "DDB_G0270260", "DDB_G0270260" ] }, "reaction_10616553": { "compartment": "compartment_984", "id": "reaction_10616553", "reactome": "R-DDI-6804099", "name": "HMGB1 binds LTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_181015", "species_10616549" ], "products": [ "species_10616551" ], "modifiers": [], "additional_components": [ "DDB_G0270260", "Q55C24", "DDB_G0270260", "species_181015" ] }, "reaction_10620682": { "compartment": "compartment_984", "id": "reaction_10620682", "reactome": "R-DDI-8869683", "name": "oxPL binds LBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584361", "species_2186967" ], "products": [ "species_10620680" ], "modifiers": [], "additional_components": [ "Q54JE8", "DDB_G0288097", "Q55BA2", "DDB_G0271242", "Q54JE7", "DDB_G0288097", "species_2186967", "Q54JE8", "DDB_G0288097", "Q55BA2", "DDB_G0271242", "Q54JE7", "DDB_G0288097" ] }, "reaction_10616557": { "compartment": "compartment_984", "id": "reaction_10616557", "reactome": "R-DDI-6804100", "name": "HMGB1 binds LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_166005", "species_10616549" ], "products": [ "species_10616555" ], "modifiers": [], "additional_components": [ "DDB_G0270260", "Q55C24", "DDB_G0270260", "species_166005" ] }, "reaction_10625430": { "compartment": "compartment_17906", "id": "reaction_10625430", "reactome": "R-DDI-9018815", "name": "RHOT1 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625411", "species_10625426" ], "products": [ "species_10625428" ], "modifiers": [], "additional_components": [ "Q55G45", "DDB_G0267830", "species_29438", "Q9U1M8", "DDB_G0274455", "P54696", "DDB_G0289447", "Q9TW28", "DDB_G0292262", "P54697", "DDB_G0272112", "Q9U1M8", "DDB_G0274455", "P54696", "DDB_G0289447", "Q9TW28", "DDB_G0292262", "P54697", "DDB_G0272112", "Q55G45", "DDB_G0267830", "species_29438" ] }, "reaction_10625416": { "compartment": "compartment_70101", "id": "reaction_10625416", "reactome": "R-DDI-9018814", "name": "RHOT1 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10625411" ], "products": [ "species_29372", "species_10625413" ], "modifiers": [ [ "species_10625411", "catalyst" ] ], "additional_components": [ "Q55G45", "DDB_G0267830", "species_29438", "Q55G45", "DDB_G0267830", "species_29420", "Q55G45", "DDB_G0267830", "species_29438" ] }, "reaction_10607623": { "compartment": "compartment_70101", "id": "reaction_10607623", "reactome": "R-DDI-5676966", "name": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5687536", "species_71284" ], "products": [ "species_5687529", "species_71285" ], "modifiers": [ [ "species_10607620", "catalyst" ] ], "additional_components": [ "DDB_G0280979" ] }, "reaction_10627360": { "compartment": "compartment_7660", "id": "reaction_10627360", "reactome": "R-DDI-9686969", "name": "APC/C:Cdh1 polyubiquitinates SKP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627357", "species_10576865" ], "products": [ "species_10585955" ], "modifiers": [ [ "species_10627357", "catalyst" ] ], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "Q54FX2", "DDB_G0290551", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "Q54FX2", "DDB_G0290551", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "Q54FX2", "DDB_G0290551" ] }, "reaction_10585442": { "compartment": "compartment_70101", "id": "reaction_10585442", "reactome": "R-DDI-174195", "name": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585356", "species_10577037" ], "products": [ "species_10585371" ], "modifiers": [ [ "species_10585356", "catalyst" ] ], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54KM3", "DDB_G0287259", "Q86HN7", "DDB_G0274503", "Q54WX4", "DDB_G0279343", "Q54MZ3", "DDB_G0285601", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54KM3", "DDB_G0287259", "Q86HN7", "DDB_G0274503", "Q54WX4", "DDB_G0279343", "Q54MZ3", "DDB_G0285601", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54KM3", "DDB_G0287259", "Q86HN7", "DDB_G0274503", "Q54WX4", "DDB_G0279343", "Q54MZ3", "DDB_G0285601" ] }, "reaction_10585957": { "compartment": "compartment_7660", "id": "reaction_10585957", "reactome": "R-DDI-188191", "name": "APC/C:Cdh1-mediated degradation of Skp2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585955" ], "products": [ "species_10577547", "species_10585336", "species_10576865" ], "modifiers": [ [ "species_10585327", "catalyst" ] ], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "Q54FX2", "DDB_G0290551", "DDB_G0290551", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q27563", "DDB_G0267408", "P02889", "DDB_G0272564", "P34119", "DDB_G0280969", "Q552Y8", "DDB_G0275753", "Q55G04", "DDB_G0268538", "Q967U1", "DDB_G0285099", "Q54XM7", "DDB_G0278847", "P34120", "DDB_G0272831", "Q86A21", "DDB_G0272969", "Q54S82", "DDB_G0282617", "Q54QR2", "DDB_G0283679", "Q55DY7", "DDB_G0269472", "Q55D66", "DDB_G0269772", "Q556Q0", "DDB_G0273163", "Q54BC8", "DDB_G0293784", "Q55GJ6", "DDB_G0267390", "Q55BV5", "DDB_G0270784", "Q86JA1", "DDB_G0276917", "Q54PN7", "DDB_G0284415", "P34123", "DDB_G0289003", "P34124", "DDB_G0292382", "Q54PJ1", "DDB_G0284517", "Q54JM5", "DDB_G0287953", "Q54HW1", "DDB_G0289189", "Q54UB5", "DDB_G0281315", "Q54UJ0", "DDB_G0281051", "Q54NQ0", "DDB_G0285105", "Q54BC6", "DDB_G0293752", "Q1ZXD3", "DDB_G0288621", "Q553E0", "DDB_G0275775", "Q86IJ1", "DDB_G0272566", "Q559F4", "DDB_G0272951", "Q27562", "DDB_G0282363", "Q55C75", "DDB_G0270188", "Q54DM7", "DDB_G0292122", "Q54WI8", "DDB_G0279633" ] }, "reaction_10585373": { "compartment": "compartment_70101", "id": "reaction_10585373", "reactome": "R-DDI-174105", "name": "Degradation of multiubiquitinated cell cycle proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585371" ], "products": [ "species_10577037", "species_10577384" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54KM3", "DDB_G0287259", "Q86HN7", "DDB_G0274503", "Q54WX4", "DDB_G0279343", "Q54MZ3", "DDB_G0285601", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54KM3", "DDB_G0287259", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10585358": { "compartment": "compartment_70101", "id": "reaction_10585358", "reactome": "R-DDI-174088", "name": "Association of cell cycle proteins with the APC/C:Cdh1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585354", "species_10577384" ], "products": [ "species_10585356" ], "modifiers": [], "additional_components": [ "Q86HN7", "DDB_G0274503", "Q54XS6", "DDB_G0278775", "Q54WX4", "DDB_G0279343", "Q54MZ3", "DDB_G0285601", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54KM3", "DDB_G0287259", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54KM3", "DDB_G0287259", "Q86HN7", "DDB_G0274503", "Q54WX4", "DDB_G0279343", "Q54MZ3", "DDB_G0285601" ] }, "reaction_10585448": { "compartment": "compartment_70101", "id": "reaction_10585448", "reactome": "R-DDI-174203", "name": "SCF-mediated degradation of Emi1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585434" ], "products": [ "species_10577037", "species_10585446", "species_10585428" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q7KWS8", "DDB_G0276283", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54KM3", "DDB_G0287259", "Q54MZ3", "DDB_G0285601", "Q7KWS8", "DDB_G0276283", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10585437": { "compartment": "compartment_70101", "id": "reaction_10585437", "reactome": "R-DDI-174159", "name": "Ubiquitination of Emi1 by SCF-beta-TrCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10585432" ], "products": [ "species_10585434" ], "modifiers": [ [ "species_10585428", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q7KWS8", "DDB_G0276283", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q7KWS8", "DDB_G0276283", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q7KWS8", "DDB_G0276283", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972" ] }, "reaction_10585961": { "compartment": "compartment_7660", "id": "reaction_10585961", "reactome": "R-DDI-188371", "name": "Association of Cyclin A:Cdk2 with Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585336", "species_10576705" ], "products": [ "species_10585338" ], "modifiers": [], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "P34112", "DDB_G0272813", "P34112", "DDB_G0272813", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259" ] }, "reaction_10583654": { "compartment": "compartment_70101", "id": "reaction_10583654", "reactome": "R-DDI-141423", "name": "Binding of the MCC complex to the APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583650", "species_10577377" ], "products": [ "species_10583652" ], "modifiers": [], "additional_components": [ "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601" ] }, "reaction_10583660": { "compartment": "compartment_70101", "id": "reaction_10583660", "reactome": "R-DDI-141437", "name": "Formation of the MCC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583643", "species_10583638", "species_10583648", "species_10583633" ], "products": [ "species_10583650" ], "modifiers": [], "additional_components": [ "DDB_G0285601", "DDB_G0292134", "DDB_G0273201", "DDB_G0292676", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601" ] }, "reaction_10583658": { "compartment": "compartment_70101", "id": "reaction_10583658", "reactome": "R-DDI-141429", "name": "Inactivation of APC/C via CDC20 sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583643", "species_10583648" ], "products": [ "species_10583656" ], "modifiers": [], "additional_components": [ "DDB_G0285601", "DDB_G0273201", "Q556Y9", "DDB_G0273201", "Q54MZ3", "DDB_G0285601" ] }, "reaction_10585343": { "compartment": "compartment_7660", "id": "reaction_10585343", "reactome": "R-DDI-174079", "name": "Phosphorylation of Cdh1 by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10585338" ], "products": [ "species_113582", "species_10585340" ], "modifiers": [ [ "species_10585338", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "P34112", "DDB_G0272813", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "P34112", "DDB_G0272813", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259" ] }, "reaction_10585390": { "compartment": "compartment_7660", "id": "reaction_10585390", "reactome": "R-DDI-174139", "name": "Dissociation of phospho-Cdh1 from the APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585236" ], "products": [ "species_10585192", "species_10585234" ], "modifiers": [], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "DDB_G0287259", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230" ] }, "reaction_10585458": { "compartment": "compartment_70101", "id": "reaction_10585458", "reactome": "R-DDI-174238", "name": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583652" ], "products": [ "species_10585386", "species_10585456" ], "modifiers": [], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54MZ3", "DDB_G0285601", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134" ] }, "reaction_10585452": { "compartment": "compartment_70101", "id": "reaction_10585452", "reactome": "R-DDI-174227", "name": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10585411" ], "products": [ "species_10585413" ], "modifiers": [ [ "species_10585386", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54MZ3", "DDB_G0285601", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54MZ3", "DDB_G0285601", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54MZ3", "DDB_G0285601" ] }, "reaction_10585369": { "compartment": "compartment_70101", "id": "reaction_10585369", "reactome": "R-DDI-174104", "name": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10585364" ], "products": [ "species_10585366" ], "modifiers": [ [ "species_10583652", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601" ] }, "reaction_10585888": { "compartment": "compartment_70101", "id": "reaction_10585888", "reactome": "R-DDI-179417", "name": "Multiubiquitination of Nek2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10585881" ], "products": [ "species_10585885" ], "modifiers": [ [ "species_10585881", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601", "Q55BN8", "DDB_G0270814", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601", "Q55BN8", "DDB_G0270814", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601", "Q55BN8", "DDB_G0270814" ] }, "reaction_10585890": { "compartment": "compartment_70101", "id": "reaction_10585890", "reactome": "R-DDI-179421", "name": "Degradation of multiubiquitinated Nek2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585885" ], "products": [ "species_10577037", "species_10583652" ], "modifiers": [], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601", "Q55BN8", "DDB_G0270814", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601" ] }, "reaction_10585883": { "compartment": "compartment_70101", "id": "reaction_10585883", "reactome": "R-DDI-179410", "name": "Association of Nek2A with MCC:APC/C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585879", "species_10583652" ], "products": [ "species_10585881" ], "modifiers": [], "additional_components": [ "DDB_G0270814", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601", "Q55BN8", "DDB_G0270814" ] }, "reaction_10585444": { "compartment": "compartment_70101", "id": "reaction_10585444", "reactome": "R-DDI-174202", "name": "Degradation of multiubiquitinated Securin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585398" ], "products": [ "species_10577037", "species_10585386" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54MZ3", "DDB_G0285601", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54MZ3", "DDB_G0285601", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10585401": { "compartment": "compartment_70101", "id": "reaction_10585401", "reactome": "R-DDI-174144", "name": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10585394" ], "products": [ "species_10585398" ], "modifiers": [ [ "species_10585386", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54MZ3", "DDB_G0285601", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54MZ3", "DDB_G0285601", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54MZ3", "DDB_G0285601" ] }, "reaction_10585384": { "compartment": "compartment_7660", "id": "reaction_10585384", "reactome": "R-DDI-174119", "name": "Free APC/C phosphorylated by Plk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585234" ], "products": [ "species_10585234" ], "modifiers": [ [ "species_10583697", "catalyst" ] ], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "DDB_G0274503" ] }, "reaction_10585330": { "compartment": "compartment_7660", "id": "reaction_10585330", "reactome": "R-DDI-174058", "name": "Degradation of multiubiquitinated Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585238" ], "products": [ "species_10585234", "species_10576865" ], "modifiers": [ [ "species_10585327", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q27563", "DDB_G0267408", "P02889", "DDB_G0272564", "P34119", "DDB_G0280969", "Q552Y8", "DDB_G0275753", "Q55G04", "DDB_G0268538", "Q967U1", "DDB_G0285099", "Q54XM7", "DDB_G0278847", "P34120", "DDB_G0272831", "Q86A21", "DDB_G0272969", "Q54S82", "DDB_G0282617", "Q54QR2", "DDB_G0283679", "Q55DY7", "DDB_G0269472", "Q55D66", "DDB_G0269772", "Q556Q0", "DDB_G0273163", "Q54BC8", "DDB_G0293784", "Q55GJ6", "DDB_G0267390", "Q55BV5", "DDB_G0270784", "Q86JA1", "DDB_G0276917", "Q54PN7", "DDB_G0284415", "P34123", "DDB_G0289003", "P34124", "DDB_G0292382", "Q54PJ1", "DDB_G0284517", "Q54JM5", "DDB_G0287953", "Q54HW1", "DDB_G0289189", "Q54UB5", "DDB_G0281315", "Q54UJ0", "DDB_G0281051", "Q54NQ0", "DDB_G0285105", "Q54BC6", "DDB_G0293752", "Q1ZXD3", "DDB_G0288621", "Q553E0", "DDB_G0275775", "Q86IJ1", "DDB_G0272566", "Q559F4", "DDB_G0272951", "Q27562", "DDB_G0282363", "Q55C75", "DDB_G0270188", "Q54DM7", "DDB_G0292122", "Q54WI8", "DDB_G0279633" ] }, "reaction_10585241": { "compartment": "compartment_7660", "id": "reaction_10585241", "reactome": "R-DDI-174057", "name": "Multiubiquitination of APC/C-associated Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585236", "species_10576865" ], "products": [ "species_10585238" ], "modifiers": [ [ "species_10585236", "catalyst" ] ], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259" ] }, "reaction_10598791": { "compartment": "compartment_172574", "id": "reaction_10598791", "reactome": "R-DDI-1675795", "name": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806198", "species_29356" ], "products": [ "species_29372", "species_1806195" ], "modifiers": [ [ "species_10598788", "catalyst" ] ], "additional_components": [ "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250" ] }, "reaction_10599016": { "compartment": "compartment_172574", "id": "reaction_10599016", "reactome": "R-DDI-1676065", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806289" ], "products": [ "species_1806212", "species_29372" ], "modifiers": [ [ "species_10598788", "catalyst" ] ], "additional_components": [ "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250" ] }, "reaction_10599004": { "compartment": "compartment_172574", "id": "reaction_10599004", "reactome": "R-DDI-1676024", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806195" ], "products": [ "species_1806198", "species_29370" ], "modifiers": [ [ "species_10598879", "catalyst" ] ], "additional_components": [ "Q54S78", "DDB_G0282625", "Q55FX5", "DDB_G0282625", "P54673", "DDB_G0278727", "P54674", "DDB_G0283081", "P54675", "DDB_G0275011", "species_74112", "species_29926", "P54676", "DDB_G0289601", "species_266099", "Q54S77", "DDB_G0282627" ] }, "reaction_10599088": { "compartment": "compartment_20699", "id": "reaction_10599088", "reactome": "R-DDI-1676185", "name": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524146" ], "products": [ "species_29370", "species_1806217" ], "modifiers": [ [ "species_10598801", "catalyst" ] ], "additional_components": [ "DDB_G0277537" ] }, "reaction_10599059": { "compartment": "compartment_20699", "id": "reaction_10599059", "reactome": "R-DDI-1676133", "name": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806217" ], "products": [ "species_29372", "species_1524146" ], "modifiers": [ [ "species_10599048", "catalyst" ] ], "additional_components": [ "DDB_G0271630" ] }, "reaction_10598871": { "compartment": "compartment_20699", "id": "reaction_10598871", "reactome": "R-DDI-1675928", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806217" ], "products": [ "species_1806230", "species_29370" ], "modifiers": [ [ "species_10598868", "catalyst" ] ], "additional_components": [ "Q55FX5", "DDB_G0282625", "P54673", "DDB_G0278727", "P54674", "DDB_G0283081", "P54675", "DDB_G0275011", "Q54S78", "DDB_G0282625", "species_74112", "species_29926" ] }, "reaction_10599081": { "compartment": "compartment_20699", "id": "reaction_10599081", "reactome": "R-DDI-1676152", "name": "PI4KB binds to ARF1/3:GTP at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599079", "species_10598835" ], "products": [ "species_10598837" ], "modifiers": [], "additional_components": [ "P54677", "DDB_G0288485", "Q54LR9", "DDB_G0286479", "species_29438", "O00909", "DDB_G0289173", "Q54Y34", "DDB_G0292332", "Q1ZXA5", "DDB_G0292332", "Q54YV7", "DDB_G0278057", "Q54HK2", "DDB_G0289435", "Q55AR1", "DDB_G0271792", "Q54JJ3", "DDB_G0288015", "Q54SH9", "DDB_G0282457", "Q54V41", "DDB_G0280633", "Q54V47", "DDB_G0280621", "Q54VB0", "DDB_G0280479", "P54677", "DDB_G0288485", "Q54LR9", "DDB_G0286479", "species_29438", "O00909", "DDB_G0289173", "Q54Y34", "DDB_G0292332", "Q1ZXA5", "DDB_G0292332", "Q54YV7", "DDB_G0278057", "Q54HK2", "DDB_G0289435", "Q55AR1", "DDB_G0271792", "Q54JJ3", "DDB_G0288015", "Q54SH9", "DDB_G0282457", "Q54V41", "DDB_G0280633", "Q54V47", "DDB_G0280621", "Q54VB0", "DDB_G0280479" ] }, "reaction_10598809": { "compartment": "compartment_20699", "id": "reaction_10598809", "reactome": "R-DDI-1675824", "name": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806165", "species_29356" ], "products": [ "species_29372", "species_1806217" ], "modifiers": [ [ "species_10598806", "catalyst" ] ], "additional_components": [ "DDB_G0267462" ] }, "reaction_10598840": { "compartment": "compartment_20699", "id": "reaction_10598840", "reactome": "R-DDI-1675883", "name": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524146" ], "products": [ "species_29370", "species_1806217" ], "modifiers": [ [ "species_10598837", "catalyst" ] ], "additional_components": [ "P54677", "DDB_G0288485", "Q54LR9", "DDB_G0286479", "species_29438", "O00909", "DDB_G0289173", "Q54Y34", "DDB_G0292332", "Q1ZXA5", "DDB_G0292332", "Q54YV7", "DDB_G0278057", "Q54HK2", "DDB_G0289435", "Q55AR1", "DDB_G0271792", "Q54JJ3", "DDB_G0288015", "Q54SH9", "DDB_G0282457", "Q54V41", "DDB_G0280633", "Q54V47", "DDB_G0280621", "Q54VB0", "DDB_G0280479" ] }, "reaction_10599051": { "compartment": "compartment_20699", "id": "reaction_10599051", "reactome": "R-DDI-1676114", "name": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806159" ], "products": [ "species_29372", "species_1524146" ], "modifiers": [ [ "species_10599048", "catalyst" ] ], "additional_components": [ "DDB_G0271630" ] }, "reaction_10599115": { "compartment": "compartment_20699", "id": "reaction_10599115", "reactome": "R-DDI-1676204", "name": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806230", "species_29356" ], "products": [ "species_29372", "species_1806217" ], "modifiers": [ [ "species_10599112", "catalyst" ] ], "additional_components": [ "Q54MG8", "DDB_G0285967" ] }, "reaction_10598911": { "compartment": "compartment_20699", "id": "reaction_10598911", "reactome": "R-DDI-1675961", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524146" ], "products": [ "species_29370", "species_1806159" ], "modifiers": [ [ "species_10598879", "catalyst" ] ], "additional_components": [ "Q54S78", "DDB_G0282625", "Q55FX5", "DDB_G0282625", "P54673", "DDB_G0278727", "P54674", "DDB_G0283081", "P54675", "DDB_G0275011", "species_74112", "species_29926", "P54676", "DDB_G0289601", "species_266099", "Q54S77", "DDB_G0282627" ] }, "reaction_10599056": { "compartment": "compartment_12045", "id": "reaction_10599056", "reactome": "R-DDI-1676124", "name": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806234" ], "products": [ "species_29372", "species_426639" ], "modifiers": [ [ "species_10599053", "catalyst" ] ], "additional_components": [ "DDB_G0271630" ] }, "reaction_10598804": { "compartment": "compartment_12045", "id": "reaction_10598804", "reactome": "R-DDI-1675813", "name": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426639" ], "products": [ "species_29370", "species_1806234" ], "modifiers": [ [ "species_10598801", "catalyst" ] ], "additional_components": [ "DDB_G0277537" ] }, "reaction_10617403": { "compartment": "compartment_70101", "id": "reaction_10617403", "reactome": "R-DDI-6809777", "name": "PI3P is dephosphorylated to PI by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5676030" ], "products": [ "species_29372", "species_426639" ], "modifiers": [ [ "species_10617398", "catalyst" ] ], "additional_components": [ "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54TD5", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258" ] }, "reaction_10617400": { "compartment": "compartment_70101", "id": "reaction_10617400", "reactome": "R-DDI-6809764", "name": "SBF1 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598734", "species_10617396" ], "products": [ "species_10617398" ], "modifiers": [], "additional_components": [ "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54TD5", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54TD5", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258" ] }, "reaction_10617406": { "compartment": "compartment_70101", "id": "reaction_10617406", "reactome": "R-DDI-6809778", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6809774" ], "products": [ "species_29372", "species_422529" ], "modifiers": [ [ "species_10617398", "catalyst" ] ], "additional_components": [ "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54TD5", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258" ] }, "reaction_10599073": { "compartment": "compartment_876", "id": "reaction_10599073", "reactome": "R-DDI-1676149", "name": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_202247" ], "products": [ "species_29372", "species_392417" ], "modifiers": [ [ "species_10587224", "catalyst" ] ], "additional_components": [ "DDB_G0286557" ] }, "reaction_10598595": { "compartment": "compartment_876", "id": "reaction_10598595", "reactome": "R-DDI-1675773", "name": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_202247" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10598592", "catalyst" ] ], "additional_components": [ "Q54M96", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635", "Q54VR4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q86D86", "DDB_G0283615", "Q54DL4", "DDB_G0292190" ] }, "reaction_10599043": { "compartment": "compartment_876", "id": "reaction_10599043", "reactome": "R-DDI-1676109", "name": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10599040", "catalyst" ] ], "additional_components": [ "Q54DK0", "DDB_G0292252", "P54675", "DDB_G0275011", "P54673", "DDB_G0278727", "Q54S78", "DDB_G0282625", "Q55FX5", "DDB_G0282625", "P54674", "DDB_G0283081", "species_74112", "species_29926", "species_266099" ] }, "reaction_10617313": { "compartment": "compartment_70101", "id": "reaction_10617313", "reactome": "R-DDI-6809254", "name": "MTMR8 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617309", "species_10617283" ], "products": [ "species_10617311" ], "modifiers": [], "additional_components": [ "Q55AZ2", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54TD5", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54TD5", "DDB_G0293258", "Q54PT8", "DDB_G0293258" ] }, "reaction_10598914": { "compartment": "compartment_876", "id": "reaction_10598914", "reactome": "R-DDI-1675988", "name": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_392417" ], "products": [ "species_29372", "species_426658" ], "modifiers": [ [ "species_10598818", "catalyst" ] ], "additional_components": [ "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392" ] }, "reaction_10599013": { "compartment": "compartment_876", "id": "reaction_10599013", "reactome": "R-DDI-1676048", "name": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10599010", "catalyst" ] ], "additional_components": [ "Q54DK0", "DDB_G0292252", "P54675", "DDB_G0275011", "P54673", "DDB_G0278727", "Q54S78", "DDB_G0282625", "Q55FX5", "DDB_G0282625", "P54674", "DDB_G0283081" ] }, "reaction_10598821": { "compartment": "compartment_876", "id": "reaction_10598821", "reactome": "R-DDI-1675836", "name": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806224" ], "products": [ "species_1806276", "species_29372" ], "modifiers": [ [ "species_10598818", "catalyst" ] ], "additional_components": [ "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392" ] }, "reaction_10598796": { "compartment": "compartment_876", "id": "reaction_10598796", "reactome": "R-DDI-1675810", "name": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426658" ], "products": [ "species_1806240", "species_29370" ], "modifiers": [ [ "species_10598793", "catalyst" ] ], "additional_components": [ "Q54M96", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635", "Q54VR4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q86D86", "DDB_G0283615", "Q54DL4", "DDB_G0292190" ] }, "reaction_10599086": { "compartment": "compartment_876", "id": "reaction_10599086", "reactome": "R-DDI-1676177", "name": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_29372", "species_392417" ], "modifiers": [ [ "species_10599083", "catalyst" ] ], "additional_components": [ "Q54PV1", "DDB_G0284187", "Q54W40", "DDB_G0279927", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392" ] }, "reaction_10617325": { "compartment": "compartment_70101", "id": "reaction_10617325", "reactome": "R-DDI-6809309", "name": "MTMR6 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617309", "species_10598992" ], "products": [ "species_10617323" ], "modifiers": [], "additional_components": [ "Q55AZ2", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54TD5", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258" ] }, "reaction_10617330": { "compartment": "compartment_876", "id": "reaction_10617330", "reactome": "R-DDI-6809320", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806224" ], "products": [ "species_29372", "species_1806240" ], "modifiers": [ [ "species_10617327", "catalyst" ] ], "additional_components": [ "Q54PT8", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258" ] }, "reaction_10599091": { "compartment": "compartment_876", "id": "reaction_10599091", "reactome": "R-DDI-1676203", "name": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806224" ], "products": [ "species_29372", "species_1806240" ], "modifiers": [ [ "species_10598999", "catalyst" ] ], "additional_components": [ "Q54PT8", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54H00", "DDB_G0289807", "Q54D97", "DDB_G0292392" ] }, "reaction_10617333": { "compartment": "compartment_876", "id": "reaction_10617333", "reactome": "R-DDI-6809325", "name": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_29356" ], "products": [ "species_29372", "species_426658" ], "modifiers": [ [ "species_10617327", "catalyst" ] ], "additional_components": [ "Q54PT8", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258" ] }, "reaction_10599062": { "compartment": "compartment_876", "id": "reaction_10599062", "reactome": "R-DDI-1676134", "name": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_113592" ], "products": [ "species_1806224", "species_29370" ], "modifiers": [ [ "species_10598793", "catalyst" ] ], "additional_components": [ "Q54M96", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635", "Q54VR4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q86D86", "DDB_G0283615", "Q54DL4", "DDB_G0292190" ] }, "reaction_10587227": { "compartment": "compartment_70101", "id": "reaction_10587227", "reactome": "R-DDI-199456", "name": "PTEN dephosphorylates PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179838" ], "products": [ "species_29372", "species_179856" ], "modifiers": [ [ "species_10587224", "catalyst" ] ], "additional_components": [ "DDB_G0286557" ] }, "reaction_10599002": { "compartment": "compartment_876", "id": "reaction_10599002", "reactome": "R-DDI-1675994", "name": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_29356" ], "products": [ "species_29372", "species_426658" ], "modifiers": [ [ "species_10598999", "catalyst" ] ], "additional_components": [ "Q54PT8", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54H00", "DDB_G0289807", "Q54D97", "DDB_G0292392" ] }, "reaction_10598909": { "compartment": "compartment_876", "id": "reaction_10598909", "reactome": "R-DDI-1675949", "name": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179838" ], "products": [ "species_29372", "species_202247" ], "modifiers": [ [ "species_10598906", "catalyst" ] ], "additional_components": [ "Q54PV1", "DDB_G0284187", "Q54W40", "DDB_G0279927", "Q8I7P3", "DDB_G0267462" ] }, "reaction_10599070": { "compartment": "compartment_876", "id": "reaction_10599070", "reactome": "R-DDI-1676145", "name": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_113592" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10599067", "catalyst" ] ], "additional_components": [ "Q86D86", "DDB_G0283615", "Q54DL4", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635" ] }, "reaction_10618317": { "compartment": "compartment_876", "id": "reaction_10618317", "reactome": "R-DDI-6814797", "name": "ENPP6 hydrolyzes lysophosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_2239407" ], "products": [ "species_6814794", "species_6814795" ], "modifiers": [ [ "species_10618314", "catalyst" ] ], "additional_components": [ "DDB_G0285897" ] }, "reaction_10598240": { "compartment": "compartment_20699", "id": "reaction_10598240", "reactome": "R-DDI-1483211", "name": "PC:PITPNB is transported from the Golgi membrane to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598146" ], "products": [ "species_10598238" ], "modifiers": [], "additional_components": [ "Q9NCL8", "DDB_G0290069", "species_426925", "species_426925", "Q9NCL8", "DDB_G0290069" ] }, "reaction_10598259": { "compartment": "compartment_12045", "id": "reaction_10598259", "reactome": "R-DDI-1483229", "name": "PI:PITPNB is transported from the ER membrane to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598242" ], "products": [ "species_10598144" ], "modifiers": [], "additional_components": [ "species_426639", "Q9NCL8", "DDB_G0290069", "species_426639", "Q9NCL8", "DDB_G0290069" ] }, "reaction_10598148": { "compartment": "compartment_20699", "id": "reaction_10598148", "reactome": "R-DDI-1483087", "name": "PI is exchanged with PC by PITPNB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429785", "species_10598144" ], "products": [ "species_1524146", "species_10598146" ], "modifiers": [], "additional_components": [ "species_426639", "Q9NCL8", "DDB_G0290069", "Q9NCL8", "DDB_G0290069", "species_426925" ] }, "reaction_10599024": { "compartment": "compartment_171062", "id": "reaction_10599024", "reactome": "R-DDI-1676105", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806205" ], "products": [ "species_29372", "species_1806259" ], "modifiers": [ [ "species_10599021", "catalyst" ] ], "additional_components": [ "Q54C52", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PT8", "DDB_G0293258", "Q55AZ2", "DDB_G0293258" ] }, "reaction_10617363": { "compartment": "compartment_70101", "id": "reaction_10617363", "reactome": "R-DDI-6809680", "name": "MTMR12 binds MTM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617359", "species_10598708" ], "products": [ "species_10617361" ], "modifiers": [], "additional_components": [ "Q54YC2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PT8", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PT8", "DDB_G0293258", "Q55AZ2", "DDB_G0293258" ] }, "reaction_10598882": { "compartment": "compartment_171062", "id": "reaction_10598882", "reactome": "R-DDI-1675939", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806199", "species_113592" ], "products": [ "species_29370", "species_1806200" ], "modifiers": [ [ "species_10598879", "catalyst" ] ], "additional_components": [ "Q54S78", "DDB_G0282625", "Q55FX5", "DDB_G0282625", "P54673", "DDB_G0278727", "P54674", "DDB_G0283081", "P54675", "DDB_G0275011", "species_74112", "species_29926", "P54676", "DDB_G0289601", "species_266099", "Q54S77", "DDB_G0282627" ] }, "reaction_10617367": { "compartment": "compartment_70101", "id": "reaction_10617367", "reactome": "R-DDI-6809707", "name": "MTMR12 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598734", "species_10617359" ], "products": [ "species_10617365" ], "modifiers": [], "additional_components": [ "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258" ] }, "reaction_10618629": { "compartment": "compartment_70101", "id": "reaction_10618629", "reactome": "R-DDI-8849969", "name": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8849959" ], "products": [ "species_29372", "species_8849958" ], "modifiers": [ [ "species_10618626", "catalyst" ] ], "additional_components": [ "species_179838", "species_1806238", "species_179856", "species_1806200", "species_1806205", "species_6810408", "Q86HL0", "DDB_G0290653", "Q55AW9", "DDB_G0271630", "Q54FY6", "DDB_G0290653" ] }, "reaction_10599065": { "compartment": "compartment_171062", "id": "reaction_10599065", "reactome": "R-DDI-1676141", "name": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806200" ], "products": [ "species_29372", "species_1806199" ], "modifiers": [ [ "species_10599021", "catalyst" ] ], "additional_components": [ "Q54C52", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PT8", "DDB_G0293258", "Q55AZ2", "DDB_G0293258" ] }, "reaction_10617370": { "compartment": "compartment_171062", "id": "reaction_10617370", "reactome": "R-DDI-6809720", "name": "PI3P is dephosphorylated to PI by MTM1:MTMR12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806200" ], "products": [ "species_29372", "species_1806199" ], "modifiers": [ [ "species_10617361", "catalyst" ] ], "additional_components": [ "Q54C52", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PT8", "DDB_G0293258", "Q55AZ2", "DDB_G0293258" ] }, "reaction_10599118": { "compartment": "compartment_171062", "id": "reaction_10599118", "reactome": "R-DDI-1676206", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806180", "species_113592" ], "products": [ "species_29370", "species_1806238" ], "modifiers": [ [ "species_10598854", "catalyst" ] ], "additional_components": [ "Q54S78", "DDB_G0282625", "Q55FX5", "DDB_G0282625", "P54673", "DDB_G0278727", "P54674", "DDB_G0283081", "P54675", "DDB_G0275011", "species_74112", "species_29926" ] }, "reaction_10598208": { "compartment": "compartment_12045", "id": "reaction_10598208", "reactome": "R-DDI-1483182", "name": "PC is hydrolyzed to PA and choline by PLD1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_264618", "species_426755" ], "modifiers": [ [ "species_10598205", "catalyst" ] ], "additional_components": [ "Q54WR4", "DDB_G0279483", "Q54Z25", "DDB_G0277949", "Q54Q49", "DDB_G0284155", "Q54UK0", "DDB_G0281031" ] }, "reaction_10612690": { "compartment": "compartment_70101", "id": "reaction_10612690", "reactome": "R-DDI-6786650", "name": "DDHD1,2 hydrolyse PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1602448" ], "products": [ "species_1602447", "species_1602366" ], "modifiers": [ [ "species_10612687", "catalyst" ] ], "additional_components": [ "Q86KP6", "DDB_G0276935", "Q54EA5", "DDB_G0291694", "Q55DN9", "DDB_G0276935", "Q55DP0", "DDB_G0276935" ] }, "reaction_10594009": { "compartment": "compartment_12045", "id": "reaction_10594009", "reactome": "R-DDI-549112", "name": "G3P is acylated to 1-acyl LPA by AGPAT6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_76114" ], "products": [ "species_1500604", "species_76194" ], "modifiers": [ [ "species_10581703", "catalyst" ] ], "additional_components": [ "DDB_G0274969" ] }, "reaction_10623946": { "compartment": "compartment_17906", "id": "reaction_10623946", "reactome": "R-DDI-8954398", "name": "PLD6 dimer hydrolyses cardiolipin to PA and PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189422", "species_8954419" ], "products": [ "species_8954401", "species_1500590" ], "modifiers": [ [ "species_10623943", "catalyst" ] ], "additional_components": [ "Q54TK6", "DDB_G0281695" ] }, "reaction_10585976": { "compartment": "compartment_5460", "id": "reaction_10585976", "reactome": "R-DDI-188467", "name": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_188458" ], "products": [ "species_31649", "species_188451" ], "modifiers": [ [ "species_10585973", "catalyst" ] ], "additional_components": [ "DDB_G0283951" ] }, "reaction_10597949": { "compartment": "compartment_17906", "id": "reaction_10597949", "reactome": "R-DDI-1482548", "name": "1-acyl LPA is acylated to PA by AGPAT5 (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500580" ], "products": [ "species_1500590", "species_76194" ], "modifiers": [ [ "species_10597946", "catalyst" ] ], "additional_components": [ "DDB_G0288523" ] }, "reaction_10622766": { "compartment": "compartment_5460", "id": "reaction_10622766", "reactome": "R-DDI-8878654", "name": "ACP6 hydrolyses MYS-LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8878649", "species_113521" ], "products": [ "species_113548", "species_8934414" ], "modifiers": [ [ "species_10622763", "catalyst" ] ], "additional_components": [ "DDB_G0284363" ] }, "reaction_10581726": { "compartment": "compartment_12045", "id": "reaction_10581726", "reactome": "R-DDI-75885", "name": "1-acyl LPA is acylated to PA by AGPAT (LPAAT)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500604", "species_1500578" ], "products": [ "species_426755", "species_76194" ], "modifiers": [ [ "species_10581723", "catalyst" ] ], "additional_components": [ "Q54IT8", "DDB_G0288523", "Q55CZ2", "DDB_G0288523", "Q54EU4", "DDB_G0291332", "Q554U0", "DDB_G0274969", "Q54X10", "DDB_G0279277", "Q54IG1", "DDB_G0288863" ] }, "reaction_10611940": { "compartment": "compartment_12045", "id": "reaction_10611940", "reactome": "R-DDI-5696448", "name": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696449", "species_6782195" ], "products": [ "species_76194", "species_1500596" ], "modifiers": [ [ "species_10611937", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10598028": { "compartment": "compartment_12045", "id": "reaction_10598028", "reactome": "R-DDI-1482889", "name": "DAG is acylated to TAG by DGAT1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_1500594", "species_76194" ], "modifiers": [ [ "species_10598025", "catalyst" ] ], "additional_components": [ "Q55BH9", "DDB_G0271342", "Q54GC1", "DDB_G0290279" ] }, "reaction_10618492": { "compartment": "compartment_12045", "id": "reaction_10618492", "reactome": "R-DDI-8848580", "name": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_1500594", "species_76194" ], "modifiers": [ [ "species_10618487", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10598017": { "compartment": "compartment_12045", "id": "reaction_10598017", "reactome": "R-DDI-1482861", "name": "MLCL is acylated to CL by LCLAT1 (ER)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1524069" ], "products": [ "species_1524081", "species_76194" ], "modifiers": [ [ "species_10581717", "catalyst" ] ], "additional_components": [ "Q55CZ2", "DDB_G0288523", "Q54IT8", "DDB_G0288523" ] }, "reaction_10598019": { "compartment": "compartment_12045", "id": "reaction_10598019", "reactome": "R-DDI-1482867", "name": "DLCL is acylated to MLCL by LCLAT1 (ER)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524080", "species_1500578" ], "products": [ "species_76194", "species_1524069" ], "modifiers": [ [ "species_10581717", "catalyst" ] ], "additional_components": [ "Q55CZ2", "DDB_G0288523", "Q54IT8", "DDB_G0288523" ] }, "reaction_10597996": { "compartment": "compartment_70616", "id": "reaction_10597996", "reactome": "R-DDI-1482781", "name": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524075", "species_1498773" ], "products": [ "species_1524072", "species_1524079" ], "modifiers": [ [ "species_10597993", "catalyst" ] ], "additional_components": [ "DDB_G0291922" ] }, "reaction_10598012": { "compartment": "compartment_70616", "id": "reaction_10598012", "reactome": "R-DDI-1482850", "name": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524083", "species_1498773" ], "products": [ "species_1524072", "species_1524089" ], "modifiers": [ [ "species_10597993", "catalyst" ] ], "additional_components": [ "DDB_G0291922" ] }, "reaction_10605155": { "compartment": "compartment_876", "id": "reaction_10605155", "reactome": "R-DDI-5333678", "name": "CPNEs bind PL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605151", "species_171142" ], "products": [ "species_10605153" ], "modifiers": [ [ "species_74016", "catalyst" ] ], "additional_components": [ "Q54P51", "DDB_G0284791", "Q55GG1", "DDB_G0267688", "Q1ZXB3", "DDB_G0291498", "Q54FY7", "DDB_G0290529", "Q7YXU4", "DDB_G0293008", "Q86K21", "DDB_G0272875", "species_171142", "Q54P51", "DDB_G0284791", "Q55GG1", "DDB_G0267688", "Q1ZXB3", "DDB_G0291498", "Q54FY7", "DDB_G0290529", "Q7YXU4", "DDB_G0293008", "Q86K21", "DDB_G0272875" ] }, "reaction_10598166": { "compartment": "compartment_12045", "id": "reaction_10598166", "reactome": "R-DDI-1483121", "name": "PA is converted to CDP-DAG by CDS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_426755" ], "products": [ "species_111294", "species_426955" ], "modifiers": [ [ "species_10598163", "catalyst" ] ], "additional_components": [ "Q55D90", "DDB_G0269742", "species_29926" ] }, "reaction_10598092": { "compartment": "compartment_12045", "id": "reaction_10598092", "reactome": "R-DDI-1482976", "name": "CDP-DAG is converted to PI by CDIPT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426955", "species_426910" ], "products": [ "species_426639", "species_109395" ], "modifiers": [ [ "species_10598089", "catalyst" ] ], "additional_components": [ "Q54P27", "DDB_G0284857", "species_29926", "species_266099" ] }, "reaction_10620477": { "compartment": "compartment_70101", "id": "reaction_10620477", "reactome": "R-DDI-8869241", "name": "PITPNM1,2,3 exchange PI for PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426639", "species_1602448" ], "products": [ "species_426755", "species_426658" ], "modifiers": [ [ "species_10620474", "catalyst" ] ], "additional_components": [ "Q55DN9", "DDB_G0276935", "Q54EA5", "DDB_G0291694", "Q86KP6", "DDB_G0276935", "Q55DP0", "DDB_G0276935", "Q9NCL7", "DDB_G0274579", "Q54D93", "DDB_G0292426", "Q54VC7", "DDB_G0280449" ] }, "reaction_10598213": { "compartment": "compartment_12045", "id": "reaction_10598213", "reactome": "R-DDI-1483186", "name": "PC is converted to PS by PTDSS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_200736" ], "products": [ "species_264618", "species_1500646" ], "modifiers": [ [ "species_10598210", "catalyst" ] ], "additional_components": [ "DDB_G0278159" ] }, "reaction_10598156": { "compartment": "compartment_12045", "id": "reaction_10598156", "reactome": "R-DDI-1483089", "name": "PE is converted to PS by PTDSS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736", "species_1500581" ], "products": [ "species_1498751", "species_1500646" ], "modifiers": [ [ "species_10598153", "catalyst" ] ], "additional_components": [ "DDB_G0278159" ] }, "reaction_10598171": { "compartment": "compartment_70616", "id": "reaction_10598171", "reactome": "R-DDI-1483165", "name": "PA is converted to CDP-DAG by CDS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524101", "species_110577" ], "products": [ "species_159450", "species_1524064" ], "modifiers": [ [ "species_10598168", "catalyst" ] ], "additional_components": [ "DDB_G0269742" ] }, "reaction_10619810": { "compartment": "compartment_984", "id": "reaction_10619810", "reactome": "R-DDI-8865637", "name": "MFSD2A transports LPC from extracellular region to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8865642", "species_74113" ], "products": [ "species_8865629", "species_83910" ], "modifiers": [ [ "species_10619807", "catalyst" ] ], "additional_components": [ "DDB_G0282159" ] }, "reaction_10598179": { "compartment": "compartment_12045", "id": "reaction_10598179", "reactome": "R-DDI-1483174", "name": "PE is methylated to PC by PEMT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_1500581" ], "products": [ "species_426925", "species_71285" ], "modifiers": [ [ "species_10598176", "catalyst" ] ], "additional_components": [ "DDB_G0282527" ] }, "reaction_10598082": { "compartment": "compartment_20699", "id": "reaction_10598082", "reactome": "R-DDI-1482973", "name": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524057", "species_1524060" ], "products": [ "species_429785", "species_109395" ], "modifiers": [ [ "species_10598079", "catalyst" ] ], "additional_components": [ "species_29926", "species_266099", "Q54XM0", "DDB_G0278947" ] }, "reaction_10611829": { "compartment": "compartment_876", "id": "reaction_10611829", "reactome": "R-DDI-5694485", "name": "ABHD3 hydrolyses LPC(14:0) to 1AGPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5694502" ], "products": [ "species_5694457", "species_1861754" ], "modifiers": [ [ "species_10611826", "catalyst" ] ], "additional_components": [ "Q55C73", "DDB_G0270192", "Q54H38", "DDB_G0289723" ] }, "reaction_10589593": { "compartment": "compartment_984", "id": "reaction_10589593", "reactome": "R-DDI-372519", "name": "AcCho is hydrolyzed to Cho and acetate by ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_372533" ], "products": [ "species_1524044", "species_264638" ], "modifiers": [ [ "species_10589588", "catalyst" ], [ "species_10589591", "inhibitor" ] ], "additional_components": [ "Q54ET7", "DDB_G0291344", "Q86L18", "DDB_G0291344", "P18142", "DDB_G0283085", "Q54N21", "DDB_G0291344", "Q54WD8", "DDB_G0291344", "P21837", "DDB_G0285419", "Q54ET7", "DDB_G0291344", "Q86L18", "DDB_G0291344", "P18142", "DDB_G0283085", "Q54N21", "DDB_G0291344", "Q54WD8", "DDB_G0291344", "P21837", "DDB_G0285419" ] }, "reaction_10598121": { "compartment": "compartment_70101", "id": "reaction_10598121", "reactome": "R-DDI-1483004", "name": "Cho is phosphorylated to PCho by CHK dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264618", "species_113592" ], "products": [ "species_29370", "species_1524071" ], "modifiers": [ [ "species_10598118", "catalyst" ] ], "additional_components": [ "Q554D8", "DDB_G0275265", "Q869T9", "DDB_G0274955" ] }, "reaction_10598137": { "compartment": "compartment_12045", "id": "reaction_10598137", "reactome": "R-DDI-1483081", "name": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_1524071" ], "products": [ "species_111294", "species_1524060" ], "modifiers": [ [ "species_10598134", "catalyst" ] ], "additional_components": [ "Q54GD2", "DDB_G0290229" ] }, "reaction_10598058": { "compartment": "compartment_12045", "id": "reaction_10598058", "reactome": "R-DDI-1482961", "name": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524060", "species_1500596" ], "products": [ "species_426925", "species_109395" ], "modifiers": [ [ "species_10598055", "catalyst" ] ], "additional_components": [ "Q8T2Q6", "DDB_G0275235", "Q54XM0", "DDB_G0278947", "Q550W1", "DDB_G0276763", "Q55AQ3", "DDB_G0271794", "species_29926", "species_266099" ] }, "reaction_10592589": { "compartment": "compartment_984", "id": "reaction_10592589", "reactome": "R-DDI-444433", "name": "Cho transports from the extracellular space to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264638" ], "products": [ "species_264618" ], "modifiers": [ [ "species_10592586", "catalyst" ] ], "additional_components": [ "Q54I48", "DDB_G0289013", "Q54IJ2", "DDB_G0288717" ] }, "reaction_10597968": { "compartment": "compartment_12045", "id": "reaction_10597968", "reactome": "R-DDI-1482635", "name": "2-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498730", "species_1500578" ], "products": [ "species_1483256", "species_76194" ], "modifiers": [ [ "species_10597938", "catalyst" ] ], "additional_components": [ "Q54IT8", "DDB_G0288523", "Q55CZ2", "DDB_G0288523", "Q54X10", "DDB_G0279277" ] }, "reaction_10597941": { "compartment": "compartment_12045", "id": "reaction_10597941", "reactome": "R-DDI-1482539", "name": "1-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498740" ], "products": [ "species_1483256", "species_76194" ], "modifiers": [ [ "species_10597938", "catalyst" ] ], "additional_components": [ "Q54IT8", "DDB_G0288523", "Q55CZ2", "DDB_G0288523", "Q54X10", "DDB_G0279277" ] }, "reaction_10597985": { "compartment": "compartment_12045", "id": "reaction_10597985", "reactome": "R-DDI-1482685", "name": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1524028" ], "products": [ "species_1498750", "species_1524021" ], "modifiers": [ [ "species_10597959", "catalyst" ] ], "additional_components": [ "DDB_G0284449" ] }, "reaction_10597962": { "compartment": "compartment_12045", "id": "reaction_10597962", "reactome": "R-DDI-1482612", "name": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_975614" ], "products": [ "species_1498750", "species_1524021" ], "modifiers": [ [ "species_10597959", "catalyst" ] ], "additional_components": [ "DDB_G0284449" ] }, "reaction_10597954": { "compartment": "compartment_12045", "id": "reaction_10597954", "reactome": "R-DDI-1482598", "name": "1-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498733", "species_1500578" ], "products": [ "species_426639", "species_76194" ], "modifiers": [ [ "species_10597951", "catalyst" ] ], "additional_components": [ "DDB_G0278541" ] }, "reaction_10598010": { "compartment": "compartment_12045", "id": "reaction_10598010", "reactome": "R-DDI-1482825", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[11]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426639" ], "products": [ "species_1498733", "species_1524021" ], "modifiers": [ [ "species_10597959", "catalyst" ] ], "additional_components": [ "DDB_G0284449" ] }, "reaction_10597965": { "compartment": "compartment_12045", "id": "reaction_10597965", "reactome": "R-DDI-1482626", "name": "2-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498737", "species_1500578" ], "products": [ "species_426639", "species_76194" ], "modifiers": [ [ "species_10597951", "catalyst" ] ], "additional_components": [ "DDB_G0278541" ] }, "reaction_10598021": { "compartment": "compartment_12045", "id": "reaction_10598021", "reactome": "R-DDI-1482884", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500581" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10597959", "catalyst" ] ], "additional_components": [ "DDB_G0284449" ] }, "reaction_10598023": { "compartment": "compartment_12045", "id": "reaction_10598023", "reactome": "R-DDI-1482887", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500581" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10598004", "catalyst" ] ], "additional_components": [ "DDB_G0283551" ] }, "reaction_10597980": { "compartment": "compartment_12045", "id": "reaction_10597980", "reactome": "R-DDI-1482646", "name": "2-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498729", "species_1500578" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10597977", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541", "Q54X10", "DDB_G0279277" ] }, "reaction_10597983": { "compartment": "compartment_12045", "id": "reaction_10597983", "reactome": "R-DDI-1482667", "name": "1-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498738" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10597977", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541", "Q54X10", "DDB_G0279277" ] }, "reaction_10597988": { "compartment": "compartment_12045", "id": "reaction_10597988", "reactome": "R-DDI-1482691", "name": "2-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498722" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10597972", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541", "Q54X10", "DDB_G0279277" ] }, "reaction_10597975": { "compartment": "compartment_12045", "id": "reaction_10597975", "reactome": "R-DDI-1482636", "name": "1-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498724" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10597972", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541", "Q54X10", "DDB_G0279277" ] }, "reaction_10620264": { "compartment": "compartment_12045", "id": "reaction_10620264", "reactome": "R-DDI-8867876", "name": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_392417", "species_1500646" ], "products": [ "species_33625", "species_1806234" ], "modifiers": [ [ "species_10620261", "catalyst" ] ], "additional_components": [ "Q86KG4", "DDB_G0272498", "Q54RM1", "DDB_G0283035", "Q54NM4", "DDB_G0285141", "Q55CR3", "DDB_G0269938", "Q55CR2", "DDB_G0269940", "Q86HV4", "DDB_G0276427", "Q86HL8", "DDB_G0274517", "Q54EF5", "DDB_G0291562", "Q8MPQ7", "DDB_G0280053" ] }, "reaction_10601149": { "compartment": "compartment_1598585", "id": "reaction_10601149", "reactome": "R-DDI-2470935", "name": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2537690", "species_10601101", "species_10601141" ], "products": [ "species_10601147" ], "modifiers": [], "additional_components": [ "Q54QR0", "DDB_G0283681", "Q54E85", "DDB_G0291752", "Q552D9", "DDB_G0276101", "Q550H7", "DDB_G0276977", "Q552Q7", "DDB_G0275929", "Q54RK7", "DDB_G0283099", "Q54S35", "DDB_G0282689", "Q54RK7", "DDB_G0283099", "Q54S35", "DDB_G0282689", "Q54QR0", "DDB_G0283681", "Q54E85", "DDB_G0291752", "Q552D9", "DDB_G0276101", "Q550H7", "DDB_G0276977", "Q552Q7", "DDB_G0275929" ] }, "reaction_10626171": { "compartment": "compartment_984", "id": "reaction_10626171", "reactome": "R-DDI-9619024", "name": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_9619052" ], "products": [ "species_8878776", "species_9619021" ], "modifiers": [ [ "species_10611415", "catalyst" ] ], "additional_components": [ "Q54ET7", "DDB_G0291344" ] }, "reaction_10582448": { "compartment": "compartment_7660", "id": "reaction_10582448", "reactome": "R-DDI-77584", "name": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582444", "species_10582432" ], "products": [ "species_10582446" ], "modifiers": [], "additional_components": [ "Q54J82", "DDB_G0288225", "Q75J91", "DDB_G0288225", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54J82", "DDB_G0288225", "Q75J91", "DDB_G0288225" ] }, "reaction_10582469": { "compartment": "compartment_7660", "id": "reaction_10582469", "reactome": "R-DDI-77585", "name": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582446", "species_10582465" ], "products": [ "species_10582467" ], "modifiers": [], "additional_components": [ "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54J82", "DDB_G0288225", "Q75J91", "DDB_G0288225", "Q55A45", "DDB_G0272320", "C7G054", "DDB_G0302414", "Q86L45", "DDB_G0273003", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "C7G054", "DDB_G0302414", "Q86L45", "DDB_G0273003", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q54RX0", "DDB_G0282863", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54J82", "DDB_G0288225", "Q75J91", "DDB_G0288225" ] }, "reaction_10582473": { "compartment": "compartment_7660", "id": "reaction_10582473", "reactome": "R-DDI-77586", "name": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582467" ], "products": [ "species_10582471", "species_10582465" ], "modifiers": [], "additional_components": [ "Q55A45", "DDB_G0272320", "C7G054", "DDB_G0302414", "Q86L45", "DDB_G0273003", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q54RX0", "DDB_G0282863", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54J82", "DDB_G0288225", "Q75J91", "DDB_G0288225", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54J82", "DDB_G0288225", "Q75J91", "DDB_G0288225", "Q55A45", "DDB_G0272320", "C7G054", "DDB_G0302414", "Q86L45", "DDB_G0273003", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q54RX0", "DDB_G0282863" ] }, "reaction_10600404": { "compartment": "compartment_70101", "id": "reaction_10600404", "reactome": "R-DDI-2161549", "name": "PGH2 is reduced to PGF2a by AKR1C3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_265283", "species_29364" ], "products": [ "species_29366", "species_879535" ], "modifiers": [ [ "species_10586594", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10589015": { "compartment": "compartment_70101", "id": "reaction_10589015", "reactome": "R-DDI-265295", "name": "Prostaglandin E synthase isomerizes PGH2 to PGE2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265283" ], "products": [ "species_265287" ], "modifiers": [ [ "species_10589012", "catalyst" ] ], "additional_components": [ "DDB_G0268042" ] }, "reaction_10600407": { "compartment": "compartment_70101", "id": "reaction_10600407", "reactome": "R-DDI-2161614", "name": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_879629" ], "products": [ "species_29366", "species_2142710" ], "modifiers": [ [ "species_10586594", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10583842": { "compartment": "compartment_5460", "id": "reaction_10583842", "reactome": "R-DDI-159567", "name": "salicylic acid + Coenzyme A + ATP => salicylate-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_159559" ], "products": [ "species_159448", "species_159450", "species_159557" ], "modifiers": [ [ "species_10583839", "catalyst" ] ], "additional_components": [ "Q8SSN6", "DDB_G0276337", "Q551W4", "DDB_G0276337" ] }, "reaction_10585793": { "compartment": "compartment_5460", "id": "reaction_10585793", "reactome": "R-DDI-177157", "name": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_177153" ], "products": [ "species_159448", "species_159450", "species_177137" ], "modifiers": [ [ "species_10583822", "catalyst" ] ], "additional_components": [ "Q8SSN6", "DDB_G0276337", "Q551W4", "DDB_G0276337" ] }, "reaction_10583825": { "compartment": "compartment_5460", "id": "reaction_10583825", "reactome": "R-DDI-159443", "name": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_159446" ], "products": [ "species_159448", "species_159450", "species_159447" ], "modifiers": [ [ "species_10583822", "catalyst" ] ], "additional_components": [ "Q8SSN6", "DDB_G0276337", "Q551W4", "DDB_G0276337" ] }, "reaction_10625238": { "compartment": "compartment_74700", "id": "reaction_10625238", "reactome": "R-DDI-9018774", "name": "RHOBTB1 binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10625234" ], "products": [ "species_10625236" ], "modifiers": [], "additional_components": [ "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "species_29438" ] }, "reaction_10625269": { "compartment": "compartment_876", "id": "reaction_10625269", "reactome": "R-DDI-9018778", "name": "RHOBTB1 binds interacting proteins at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625236", "species_10625265" ], "products": [ "species_10625267" ], "modifiers": [], "additional_components": [ "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "species_29438", "Q54NZ5", "DDB_G0284903", "B0G0Y8", "DDB_G0268634", "Q54NZ5", "DDB_G0284903", "B0G0Y8", "DDB_G0268634", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "species_29438" ] }, "reaction_10625322": { "compartment": "compartment_74700", "id": "reaction_10625322", "reactome": "R-DDI-9018787", "name": "RHOBTB2 binds interacting proteins at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625307", "species_10625318" ], "products": [ "species_10625320" ], "modifiers": [], "additional_components": [ "P34150", "DDB_G0291976", "P34149", "DDB_G0293526", "Q23862", "DDB_G0280975", "Q1ZXJ6", "DDB_G0278011", "Q54N82", "DDB_G0285453", "Q54HZ7", "DDB_G0289103", "Q9GPQ8", "DDB_G0292816", "Q54YY4", "DDB_G0278009", "Q9GPR7", "DDB_G0269240", "Q9GPQ9", "DDB_G0292560", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "P34148", "DDB_G0279605", "P34146", "DDB_G0282365", "species_29438", "Q54NZ5", "DDB_G0284903", "Q54NZ5", "DDB_G0284903", "P34150", "DDB_G0291976", "P34149", "DDB_G0293526", "Q23862", "DDB_G0280975", "Q1ZXJ6", "DDB_G0278011", "Q54N82", "DDB_G0285453", "Q54HZ7", "DDB_G0289103", "Q9GPQ8", "DDB_G0292816", "Q54YY4", "DDB_G0278009", "Q9GPR7", "DDB_G0269240", "Q9GPQ9", "DDB_G0292560", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "P34148", "DDB_G0279605", "P34146", "DDB_G0282365", "species_29438" ] }, "reaction_10625366": { "compartment": "compartment_876", "id": "reaction_10625366", "reactome": "R-DDI-9018794", "name": "RHOV binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625360", "species_10625362" ], "products": [ "species_10625364" ], "modifiers": [], "additional_components": [ "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "species_29438", "Q55DD4", "DDB_G0269696", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q55DD4", "DDB_G0269696", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "species_29438" ] }, "reaction_10625370": { "compartment": "compartment_876", "id": "reaction_10625370", "reactome": "R-DDI-9018798", "name": "RHOV binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10625368" ], "products": [ "species_29420", "species_10625360" ], "modifiers": [], "additional_components": [ "species_29420", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "species_29438" ] }, "reaction_10627382": { "compartment": "compartment_876", "id": "reaction_10627382", "reactome": "R-DDI-9691168", "name": "RAC1 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583374" ], "products": [ "species_10605813" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10624907": { "compartment": "compartment_876", "id": "reaction_10624907", "reactome": "R-DDI-9013145", "name": "RAC1 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583374", "species_10624903" ], "products": [ "species_10624905" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "Q54WW0", "DDB_G0290421", "Q54G40", "DDB_G0290421", "Q867X6", "DDB_G0267460", "Q86GL4", "DDB_G0287101", "Q54F44", "DDB_G0291117", "Q867T7", "DDB_G0288773", "Q869Q3", "DDB_G0274519", "Q55FT9", "DDB_G0267956", "Q54X65", "DDB_G0279175", "Q6UK63", "DDB_G0287855", "Q55DD4", "DDB_G0269696", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q54I34", "DDB_G0289033", "Q54K32", "DDB_G0287585", "O00899", "DDB_G0269140", "Q54Z25", "DDB_G0277949", "Q54WR4", "DDB_G0279483", "Q54Q49", "DDB_G0284155", "Q54UK0", "DDB_G0281031", "Q9XYS3", "DDB_G0289653", "Q54WW0", "DDB_G0290421", "Q54G40", "DDB_G0290421", "Q867X6", "DDB_G0267460", "Q86GL4", "DDB_G0287101", "Q54F44", "DDB_G0291117", "Q867T7", "DDB_G0288773", "Q869Q3", "DDB_G0274519", "Q55FT9", "DDB_G0267956", "Q54X65", "DDB_G0279175", "Q6UK63", "DDB_G0287855", "Q55DD4", "DDB_G0269696", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q54I34", "DDB_G0289033", "Q54K32", "DDB_G0287585", "O00899", "DDB_G0269140", "Q54Z25", "DDB_G0277949", "Q54WR4", "DDB_G0279483", "Q54Q49", "DDB_G0284155", "Q54UK0", "DDB_G0281031", "Q9XYS3", "DDB_G0289653", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10624927": { "compartment": "compartment_876", "id": "reaction_10624927", "reactome": "R-DDI-9013147", "name": "RAC1 GDIs block activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599930", "species_10624923" ], "products": [ "species_10624925" ], "modifiers": [], "additional_components": [ "species_29420", "P34144", "DDB_G0277869", "Q95UP9", "DDB_G0280049", "Q95UQ1", "DDB_G0291077", "Q95UP9", "DDB_G0280049", "Q95UQ1", "DDB_G0291077", "P34144", "DDB_G0277869", "species_29420" ] }, "reaction_10624700": { "compartment": "compartment_876", "id": "reaction_10624700", "reactome": "R-DDI-9013143", "name": "RAC1 GEFs activate RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10599930" ], "products": [ "species_10583374", "species_29420" ], "modifiers": [ [ "species_10624697", "catalyst" ] ], "additional_components": [ "species_29420", "P34144", "DDB_G0277869", "P34144", "DDB_G0277869", "species_29438", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "Q54LN3", "DDB_G0286543", "Q55BQ8", "DDB_G0292004", "Q54DS6", "DDB_G0291974", "Q54DW1", "DDB_G0292004", "Q54PB7", "DDB_G0292004", "Q54SG9", "DDB_G0282475", "Q54BV5", "DDB_G0293396", "Q54YP1", "DDB_G0293396", "Q54XW8", "DDB_G0278703", "Q54C56", "DDB_G0293396", "Q55DL8", "DDB_G0293396", "Q54BY9", "DDB_G0293396", "Q54YZ6", "DDB_G0277987", "Q54F88", "DDB_G0293396", "Q86HN1", "DDB_G0293396", "Q54DW7", "DDB_G0293396", "Q55G61", "DDB_G0268354", "Q54GP2", "DDB_G0293396", "Q54G10", "DDB_G0293396", "Q86K95", "DDB_G0293396", "Q54NG0", "DDB_G0293396", "Q54J14", "DDB_G0288377", "Q54P81", "DDB_G0293396", "Q54P24", "DDB_G0284845", "Q54SR5", "DDB_G0293396", "Q54S15", "DDB_G0293396", "Q54XA7", "DDB_G0293396", "Q54VX2", "DDB_G0293396", "Q54L90", "DDB_G0286773", "Q54WL2", "DDB_G0279569", "Q552M5", "DDB_G0276019", "Q86G47", "DDB_G0289665", "Q8IS18", "DDB_G0269252", "Q8IS19", "DDB_G0289667", "Q8SSQ3", "DDB_G0274607" ] }, "reaction_10624829": { "compartment": "compartment_876", "id": "reaction_10624829", "reactome": "R-DDI-9013144", "name": "RAC1 GAPs stimulate RAC1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583374", "species_29356" ], "products": [ "species_29372", "species_10599930" ], "modifiers": [ [ "species_10624826", "catalyst" ] ], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "species_29420", "P34144", "DDB_G0277869", "Q54BP9", "DDB_G0293510", "Q1ZXE1", "DDB_G0287895", "Q54E35", "DDB_G0291840", "Q54BF1", "DDB_G0293654", "Q86B03", "DDB_G0276833", "Q54PG5", "DDB_G0284571", "Q54FG5", "DDB_G0290873", "Q86I31", "DDB_G0275085", "Q54XE8", "DDB_G0279009", "Q553X3", "DDB_G0275185", "Q54MV3", "DDB_G0285641", "Q86IG9", "DDB_G0272694" ] }, "reaction_10624960": { "compartment": "compartment_70101", "id": "reaction_10624960", "reactome": "R-DDI-9014293", "name": "RAC2 GDIs block activation of RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624954", "species_10624919" ], "products": [ "species_10624958" ], "modifiers": [], "additional_components": [ "Q54N82", "DDB_G0285453", "P34148", "DDB_G0279605", "Q54YY4", "DDB_G0278009", "P34149", "DDB_G0293526", "Q9GPQ8", "DDB_G0292816", "P34144", "DDB_G0277869", "P34150", "DDB_G0291976", "Q9GPQ9", "DDB_G0292560", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q23862", "DDB_G0280975", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "Q54HZ7", "DDB_G0289103", "P34146", "DDB_G0282365", "Q9GPS3", "DDB_G0276967", "species_29420", "Q95UP9", "DDB_G0280049", "Q95UQ1", "DDB_G0291077", "Q95UP9", "DDB_G0280049", "Q95UQ1", "DDB_G0291077", "Q9GPQ9", "DDB_G0292560", "Q9GPR7", "DDB_G0269240", "Q9GPS0", "DDB_G0269178", "Q9GPS3", "DDB_G0276967", "O96390", "DDB_G0269176", "P34144", "DDB_G0277869", "P34145", "DDB_G0268622", "P34146", "DDB_G0282365", "P34148", "DDB_G0279605", "P34149", "DDB_G0293526", "P34150", "DDB_G0291976", "Q1ZXJ6", "DDB_G0278011", "Q23862", "DDB_G0280975", "Q54HZ7", "DDB_G0289103", "Q54N82", "DDB_G0285453", "Q54YY4", "DDB_G0278009", "Q9GPQ8", "DDB_G0292816", "species_29420" ] }, "reaction_10624982": { "compartment": "compartment_876", "id": "reaction_10624982", "reactome": "R-DDI-9014420", "name": "RAC2 translocates to the phagocytic vesicle membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583458" ], "products": [ "species_10606729" ], "modifiers": [], "additional_components": [ "Q54N82", "DDB_G0285453", "P34148", "DDB_G0279605", "Q54YY4", "DDB_G0278009", "P34149", "DDB_G0293526", "Q9GPQ8", "DDB_G0292816", "P34144", "DDB_G0277869", "P34150", "DDB_G0291976", "Q9GPQ9", "DDB_G0292560", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q23862", "DDB_G0280975", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "Q54HZ7", "DDB_G0289103", "P34146", "DDB_G0282365", "Q9GPS3", "DDB_G0276967", "species_29438", "Q9GPR7", "DDB_G0269240", "Q9GPS0", "DDB_G0269178", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34144", "DDB_G0277869", "P34145", "DDB_G0268622", "P34146", "DDB_G0282365", "P34148", "DDB_G0279605", "P34149", "DDB_G0293526", "P34150", "DDB_G0291976", "Q1ZXJ6", "DDB_G0278011", "Q23862", "DDB_G0280975", "Q54HZ7", "DDB_G0289103", "Q54N82", "DDB_G0285453", "Q54YY4", "DDB_G0278009", "Q9GPQ8", "DDB_G0292816", "Q9GPQ9", "DDB_G0292560", "species_29438" ] }, "reaction_10627542": { "compartment": "compartment_876", "id": "reaction_10627542", "reactome": "R-DDI-9714480", "name": "RAC2 translocates to the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583458" ], "products": [ "species_10627524" ], "modifiers": [], "additional_components": [ "Q54N82", "DDB_G0285453", "P34148", "DDB_G0279605", "Q54YY4", "DDB_G0278009", "P34149", "DDB_G0293526", "Q9GPQ8", "DDB_G0292816", "P34144", "DDB_G0277869", "P34150", "DDB_G0291976", "Q9GPQ9", "DDB_G0292560", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q23862", "DDB_G0280975", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "Q54HZ7", "DDB_G0289103", "P34146", "DDB_G0282365", "Q9GPS3", "DDB_G0276967", "species_29438", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "species_29438" ] }, "reaction_10624980": { "compartment": "compartment_70101", "id": "reaction_10624980", "reactome": "R-DDI-9014296", "name": "RAC2 GEFs activate RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10624954" ], "products": [ "species_29420", "species_10583458" ], "modifiers": [ [ "species_10624977", "catalyst" ] ], "additional_components": [ "Q54N82", "DDB_G0285453", "P34148", "DDB_G0279605", "Q54YY4", "DDB_G0278009", "P34149", "DDB_G0293526", "Q9GPQ8", "DDB_G0292816", "P34144", "DDB_G0277869", "P34150", "DDB_G0291976", "Q9GPQ9", "DDB_G0292560", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q23862", "DDB_G0280975", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "Q54HZ7", "DDB_G0289103", "P34146", "DDB_G0282365", "Q9GPS3", "DDB_G0276967", "species_29420", "Q54N82", "DDB_G0285453", "P34148", "DDB_G0279605", "Q54YY4", "DDB_G0278009", "P34149", "DDB_G0293526", "Q9GPQ8", "DDB_G0292816", "P34144", "DDB_G0277869", "P34150", "DDB_G0291976", "Q9GPQ9", "DDB_G0292560", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q23862", "DDB_G0280975", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "Q54HZ7", "DDB_G0289103", "P34146", "DDB_G0282365", "Q9GPS3", "DDB_G0276967", "species_29438", "Q54SG9", "DDB_G0282475", "Q54LN3", "DDB_G0286543", "Q54PB7", "DDB_G0292004" ] }, "reaction_10627540": { "compartment": "compartment_17906", "id": "reaction_10627540", "reactome": "R-DDI-9714477", "name": "RAC2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627524", "species_10627536" ], "products": [ "species_10627538" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "species_29438", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "species_29438" ] }, "reaction_10624970": { "compartment": "compartment_70101", "id": "reaction_10624970", "reactome": "R-DDI-9014294", "name": "RAC2 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624966", "species_10583458" ], "products": [ "species_10624968" ], "modifiers": [], "additional_components": [ "Q54K32", "DDB_G0287585", "Q54Z25", "DDB_G0277949", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "Q54N82", "DDB_G0285453", "P34148", "DDB_G0279605", "Q54YY4", "DDB_G0278009", "P34149", "DDB_G0293526", "Q9GPQ8", "DDB_G0292816", "P34144", "DDB_G0277869", "P34150", "DDB_G0291976", "Q9GPQ9", "DDB_G0292560", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q23862", "DDB_G0280975", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "Q54HZ7", "DDB_G0289103", "P34146", "DDB_G0282365", "Q9GPS3", "DDB_G0276967", "species_29438", "Q54N82", "DDB_G0285453", "P34148", "DDB_G0279605", "Q54YY4", "DDB_G0278009", "P34149", "DDB_G0293526", "Q9GPQ8", "DDB_G0292816", "P34144", "DDB_G0277869", "P34150", "DDB_G0291976", "Q9GPQ9", "DDB_G0292560", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q23862", "DDB_G0280975", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "Q54HZ7", "DDB_G0289103", "P34146", "DDB_G0282365", "Q9GPS3", "DDB_G0276967", "species_29438", "Q54K32", "DDB_G0287585", "Q54Z25", "DDB_G0277949", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459" ] }, "reaction_10624975": { "compartment": "compartment_70101", "id": "reaction_10624975", "reactome": "R-DDI-9014295", "name": "RAC2 GAPs stimulate RAC2 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10583458" ], "products": [ "species_29372", "species_10624954" ], "modifiers": [ [ "species_10624972", "catalyst" ] ], "additional_components": [ "Q54N82", "DDB_G0285453", "P34148", "DDB_G0279605", "Q54YY4", "DDB_G0278009", "P34149", "DDB_G0293526", "Q9GPQ8", "DDB_G0292816", "P34144", "DDB_G0277869", "P34150", "DDB_G0291976", "Q9GPQ9", "DDB_G0292560", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q23862", "DDB_G0280975", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "Q54HZ7", "DDB_G0289103", "P34146", "DDB_G0282365", "Q9GPS3", "DDB_G0276967", "species_29438", "Q54N82", "DDB_G0285453", "P34148", "DDB_G0279605", "Q54YY4", "DDB_G0278009", "P34149", "DDB_G0293526", "Q9GPQ8", "DDB_G0292816", "P34144", "DDB_G0277869", "P34150", "DDB_G0291976", "Q9GPQ9", "DDB_G0292560", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q23862", "DDB_G0280975", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "Q54HZ7", "DDB_G0289103", "P34146", "DDB_G0282365", "Q9GPS3", "DDB_G0276967", "species_29420", "Q54FF4", "DDB_G0290891", "Q8SSN9", "DDB_G0274243", "Q54TH9", "DDB_G0281739", "Q54XT6", "DDB_G0278755", "Q54J98", "DDB_G0288205", "Q55DW9", "DDB_G0269496", "Q54ND2", "DDB_G0285391" ] }, "reaction_10627580": { "compartment": "compartment_876", "id": "reaction_10627580", "reactome": "R-DDI-9714483", "name": "RAC2 translocates to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583458" ], "products": [ "species_10627578" ], "modifiers": [], "additional_components": [ "Q54N82", "DDB_G0285453", "P34148", "DDB_G0279605", "Q54YY4", "DDB_G0278009", "P34149", "DDB_G0293526", "Q9GPQ8", "DDB_G0292816", "P34144", "DDB_G0277869", "P34150", "DDB_G0291976", "Q9GPQ9", "DDB_G0292560", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q23862", "DDB_G0280975", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "Q54HZ7", "DDB_G0289103", "P34146", "DDB_G0282365", "Q9GPS3", "DDB_G0276967", "species_29438", "P34150", "DDB_G0291976", "P34149", "DDB_G0293526", "Q23862", "DDB_G0280975", "Q1ZXJ6", "DDB_G0278011", "Q54N82", "DDB_G0285453", "Q54HZ7", "DDB_G0289103", "Q9GPQ8", "DDB_G0292816", "Q54YY4", "DDB_G0278009", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "Q9GPQ9", "DDB_G0292560", "Q9GPS3", "DDB_G0276967", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "O96390", "DDB_G0269176", "P34148", "DDB_G0279605", "P34146", "DDB_G0282365", "species_29438" ] }, "reaction_10625394": { "compartment": "compartment_876", "id": "reaction_10625394", "reactome": "R-DDI-9018807", "name": "RAC3 GDIs block activation of RAC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625388", "species_10625374" ], "products": [ "species_10625392" ], "modifiers": [], "additional_components": [ "species_29420", "P34147", "DDB_G0286555", "P34147", "DDB_G0286555", "species_29420" ] }, "reaction_10627586": { "compartment": "compartment_876", "id": "reaction_10627586", "reactome": "R-DDI-9714694", "name": "RAC3 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625376" ], "products": [ "species_10627584" ], "modifiers": [], "additional_components": [ "species_29438", "P34147", "DDB_G0286555", "P34147", "DDB_G0286555", "species_29438" ] }, "reaction_10625381": { "compartment": "compartment_876", "id": "reaction_10625381", "reactome": "R-DDI-9018804", "name": "RAC3 GEFs activate RAC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10625374" ], "products": [ "species_29420", "species_10625376" ], "modifiers": [ [ "species_10625378", "catalyst" ] ], "additional_components": [ "species_29420", "P34147", "DDB_G0286555", "species_29438", "P34147", "DDB_G0286555", "Q54SG9", "DDB_G0282475" ] }, "reaction_10625386": { "compartment": "compartment_876", "id": "reaction_10625386", "reactome": "R-DDI-9018806", "name": "RAC3 GAPs stimulate RAC3 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10625376" ], "products": [ "species_29372", "species_10625374" ], "modifiers": [ [ "species_10625383", "catalyst" ] ], "additional_components": [ "species_29438", "P34147", "DDB_G0286555", "species_29420", "P34147", "DDB_G0286555", "Q54FF4", "DDB_G0290891", "Q8SSN9", "DDB_G0274243", "Q54TH9", "DDB_G0281739", "Q54XT6", "DDB_G0278755", "Q54J98", "DDB_G0288205", "Q55DW9", "DDB_G0269496", "Q54ND2", "DDB_G0285391", "Q54BF1", "DDB_G0293654", "Q86B03", "DDB_G0276833", "Q54PG5", "DDB_G0284571", "Q54E35", "DDB_G0291840", "Q54FG5", "DDB_G0290873", "Q86I31", "DDB_G0275085", "Q54XE8", "DDB_G0279009", "Q553X3", "DDB_G0275185", "Q54MV3", "DDB_G0285641", "Q86IG9", "DDB_G0272694" ] }, "reaction_10625404": { "compartment": "compartment_876", "id": "reaction_10625404", "reactome": "R-DDI-9018808", "name": "RAC3 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625400", "species_10625376" ], "products": [ "species_10625402" ], "modifiers": [], "additional_components": [ "Q867X6", "DDB_G0267460", "Q86GL4", "DDB_G0287101", "Q54F44", "DDB_G0291117", "Q867T7", "DDB_G0288773", "Q869Q3", "DDB_G0274519", "Q55FT9", "DDB_G0267956", "Q54X65", "DDB_G0279175", "Q6UK63", "DDB_G0287855", "Q9XYS3", "DDB_G0289653", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459", "species_29438", "P34147", "DDB_G0286555", "species_29438", "P34147", "DDB_G0286555", "Q867X6", "DDB_G0267460", "Q86GL4", "DDB_G0287101", "Q54F44", "DDB_G0291117", "Q867T7", "DDB_G0288773", "Q869Q3", "DDB_G0274519", "Q55FT9", "DDB_G0267956", "Q54X65", "DDB_G0279175", "Q6UK63", "DDB_G0287855", "Q9XYS3", "DDB_G0289653", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459" ] }, "reaction_10625193": { "compartment": "compartment_876", "id": "reaction_10625193", "reactome": "R-DDI-9018766", "name": "RHOU binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625189", "species_10625172" ], "products": [ "species_10625191" ], "modifiers": [], "additional_components": [ "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "species_29438", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "species_29438", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459" ] }, "reaction_10625198": { "compartment": "compartment_876", "id": "reaction_10625198", "reactome": "R-DDI-9018768", "name": "RHOU auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10625195" ], "products": [ "species_29420", "species_10625172" ], "modifiers": [ [ "species_10625195", "catalyst" ] ], "additional_components": [ "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "species_29420", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "species_29438", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "species_29420" ] }, "reaction_10625079": { "compartment": "compartment_876", "id": "reaction_10625079", "reactome": "R-DDI-9018756", "name": "RHOH binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10625063" ], "products": [ "species_10625065" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "species_29438" ] }, "reaction_10625077": { "compartment": "compartment_876", "id": "reaction_10625077", "reactome": "R-DDI-9018754", "name": "GDIs bind RHOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625065", "species_10625073" ], "products": [ "species_10625075" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "species_29438", "Q95UP9", "DDB_G0280049", "Q95UQ1", "DDB_G0291077", "Q95UP9", "DDB_G0280049", "Q95UQ1", "DDB_G0291077", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "species_29438" ] }, "reaction_10625134": { "compartment": "compartment_876", "id": "reaction_10625134", "reactome": "R-DDI-9018758", "name": "RHOH binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625065", "species_10625130" ], "products": [ "species_10625132" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "species_29438", "Q55DD4", "DDB_G0269696", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q55DD4", "DDB_G0269696", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "species_29438" ] }, "reaction_10605858": { "compartment": "compartment_876", "id": "reaction_10605858", "reactome": "R-DDI-5626549", "name": "IQGAPs bind CALM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605847", "species_10587556" ], "products": [ "species_10605853" ], "modifiers": [], "additional_components": [ "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "Q54K32", "DDB_G0287585", "P34144", "DDB_G0277869", "species_29438", "Q7Z2B8", "DDB_G0277917", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "species_74112", "Q7Z2B8", "DDB_G0277917", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "species_74112", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "Q54K32", "DDB_G0287585", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10605849": { "compartment": "compartment_70101", "id": "reaction_10605849", "reactome": "R-DDI-5626469", "name": "GTP-bound RAC1 and CDC42 bind IQGAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583374", "species_10605845" ], "products": [ "species_10605847" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "Q54K32", "DDB_G0287585", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "Q54K32", "DDB_G0287585", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10605855": { "compartment": "compartment_70101", "id": "reaction_10605855", "reactome": "R-DDI-5626507", "name": "IQGAPs bind F-actin, which is inhibited by calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599576", "species_10605847" ], "products": [ "species_10605851" ], "modifiers": [ [ "species_10605853", "inhibitor" ] ], "additional_components": [ "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54L54", "DDB_G0286893", "species_113592", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "Q54K32", "DDB_G0287585", "P34144", "DDB_G0277869", "species_29438", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "Q54K32", "DDB_G0287585", "P34144", "DDB_G0277869", "species_29438", "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54L54", "DDB_G0286893", "species_113592", "Q7Z2B8", "DDB_G0277917", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "species_74112", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "Q54K32", "DDB_G0287585", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10606803": { "compartment": "compartment_70101", "id": "reaction_10606803", "reactome": "R-DDI-5668932", "name": "PAK2 phosphorylates myosin regulatory light chain (MRLC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606794", "species_113592" ], "products": [ "species_29370", "species_10606800" ], "modifiers": [ [ "species_10605892", "catalyst" ] ], "additional_components": [ "P08799", "DDB_G0286355", "P09402", "DDB_G0277859", "P13833", "DDB_G0276077", "P08799", "DDB_G0286355", "P09402", "DDB_G0277859", "P13833", "DDB_G0276077", "Q869N2", "DDB_G0276459", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450" ] }, "reaction_10624235": { "compartment": "compartment_70101", "id": "reaction_10624235", "reactome": "R-DDI-8981926", "name": "RAC1 and CDC42 activate PAK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590382", "species_10583374" ], "products": [ "species_10590380", "species_10605872" ], "modifiers": [], "additional_components": [ "Q55GV3", "DDB_G0267450", "P34144", "DDB_G0277869", "species_29438", "DDB_G0267450", "Q55GV3", "DDB_G0267450", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10605901": { "compartment": "compartment_70101", "id": "reaction_10605901", "reactome": "R-DDI-5627775", "name": "Autophosphorylation of PAK1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10605874" ], "products": [ "species_10583374", "species_10605898", "species_29370" ], "modifiers": [ [ "species_10605874", "catalyst" ] ], "additional_components": [ "Q55GV3", "DDB_G0267450", "P34144", "DDB_G0277869", "species_29438", "Q55DD4", "DDB_G0269696", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "P34144", "DDB_G0277869", "species_29438", "Q869N2", "DDB_G0276459", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55GV3", "DDB_G0267450", "P34144", "DDB_G0277869", "species_29438", "Q55DD4", "DDB_G0269696", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459" ] }, "reaction_10624237": { "compartment": "compartment_70101", "id": "reaction_10624237", "reactome": "R-DDI-8981931", "name": "RAC1 and CDC42 activate PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583374", "species_10590378" ], "products": [ "species_10605870", "species_10590376" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459", "P34144", "DDB_G0277869", "species_29438", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459" ] }, "reaction_10606784": { "compartment": "compartment_70101", "id": "reaction_10606784", "reactome": "R-DDI-5668731", "name": "NOX3 complex:RAC1:GTP generates superoxide from oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_352327" ], "products": [ "species_70106", "species_29366", "species_3299686" ], "modifiers": [ [ "species_10606781", "catalyst" ] ], "additional_components": [ "Q867X6", "DDB_G0267460", "Q9XYS3", "DDB_G0289653", "Q54F44", "DDB_G0291117", "Q86GL4", "DDB_G0287101", "Q867T7", "DDB_G0288773", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10606786": { "compartment": "compartment_876", "id": "reaction_10606786", "reactome": "R-DDI-5668735", "name": "RAC1:GTP binds NOX3 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583374", "species_10606779" ], "products": [ "species_10606781" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "Q867X6", "DDB_G0267460", "Q9XYS3", "DDB_G0289653", "Q54F44", "DDB_G0291117", "Q86GL4", "DDB_G0287101", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "Q9XYS3", "DDB_G0289653", "Q54F44", "DDB_G0291117", "Q86GL4", "DDB_G0287101", "Q867T7", "DDB_G0288773", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10606759": { "compartment": "compartment_876", "id": "reaction_10606759", "reactome": "R-DDI-5668714", "name": "RAC1:GTP binds NOX1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583374", "species_10606755" ], "products": [ "species_10606757" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "Q867X6", "DDB_G0267460", "Q86GL4", "DDB_G0287101", "Q54F44", "DDB_G0291117", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "Q86GL4", "DDB_G0287101", "Q54F44", "DDB_G0291117", "Q867T7", "DDB_G0288773", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10606762": { "compartment": "compartment_70101", "id": "reaction_10606762", "reactome": "R-DDI-5668718", "name": "NOX1 complex:RAC1:GTP generates superoxide from oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_352327" ], "products": [ "species_70106", "species_29366", "species_3299686" ], "modifiers": [ [ "species_10606757", "catalyst" ] ], "additional_components": [ "Q867X6", "DDB_G0267460", "Q86GL4", "DDB_G0287101", "Q54F44", "DDB_G0291117", "Q867T7", "DDB_G0288773", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10613711": { "compartment": "compartment_1222693", "id": "reaction_10613711", "reactome": "R-DDI-6798174", "name": "PIK3C3:PIK3R4 phosphorylates PI to PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524165" ], "products": [ "species_1629751", "species_29370" ], "modifiers": [ [ "species_10613708", "catalyst" ] ], "additional_components": [ "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627" ] }, "reaction_10627463": { "compartment": "compartment_263163", "id": "reaction_10627463", "reactome": "R-DDI-9706390", "name": "RHOBTB3 binds interacting proteins at trans-Golgi network", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627457", "species_10627459" ], "products": [ "species_10627461" ], "modifiers": [], "additional_components": [ "species_113592", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "P36411", "DDB_G0269236", "Q54FK8", "DDB_G0290829", "Q1ZXB9", "DDB_G0290831", "Q1ZXB8", "DDB_G0294571", "Q552H0", "DDB_G0294571", "Q54FK4", "DDB_G0290833", "Q54FK2", "DDB_G0290793", "Q54FK7", "DDB_G0290779", "Q54FK5", "DDB_G0290789", "Q54NZ5", "DDB_G0284903", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "P36411", "DDB_G0269236", "Q54FK8", "DDB_G0290829", "Q1ZXB9", "DDB_G0290831", "Q1ZXB8", "DDB_G0294571", "Q552H0", "DDB_G0294571", "Q54FK4", "DDB_G0290833", "Q54FK2", "DDB_G0290793", "Q54FK7", "DDB_G0290779", "Q54FK5", "DDB_G0290789", "Q54NZ5", "DDB_G0284903", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "species_113592", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967" ] }, "reaction_10627465": { "compartment": "compartment_263163", "id": "reaction_10627465", "reactome": "R-DDI-9706393", "name": "RHOBTB3 binds ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627455", "species_113592" ], "products": [ "species_10627457" ], "modifiers": [], "additional_components": [ "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "species_113592", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967" ] }, "reaction_10627470": { "compartment": "compartment_263163", "id": "reaction_10627470", "reactome": "R-DDI-9706399", "name": "RHOBTB3 hydrolyzes ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10627457" ], "products": [ "species_29372", "species_10627467" ], "modifiers": [ [ "species_10627457", "catalyst" ] ], "additional_components": [ "species_113592", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "species_29370", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "species_113592", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967" ] }, "reaction_10625434": { "compartment": "compartment_70101", "id": "reaction_10625434", "reactome": "R-DDI-9018826", "name": "RHOT2 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10625411" ], "products": [ "species_29372", "species_10625413" ], "modifiers": [ [ "species_10625411", "catalyst" ] ], "additional_components": [ "Q55G45", "DDB_G0267830", "species_29438", "Q55G45", "DDB_G0267830", "species_29420", "Q55G45", "DDB_G0267830", "species_29438" ] }, "reaction_10625432": { "compartment": "compartment_70101", "id": "reaction_10625432", "reactome": "R-DDI-9018824", "name": "RHOT2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625411", "species_10625426" ], "products": [ "species_10625428" ], "modifiers": [], "additional_components": [ "Q55G45", "DDB_G0267830", "species_29438", "Q9U1M8", "DDB_G0274455", "P54696", "DDB_G0289447", "Q9TW28", "DDB_G0292262", "P54697", "DDB_G0272112", "Q9U1M8", "DDB_G0274455", "P54696", "DDB_G0289447", "Q9TW28", "DDB_G0292262", "P54697", "DDB_G0272112", "Q55G45", "DDB_G0267830", "species_29438" ] }, "reaction_10588961": { "compartment": "compartment_70101", "id": "reaction_10588961", "reactome": "R-DDI-264444", "name": "Autoubiquitination of phospho-COP1(Ser-387 )", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10588954" ], "products": [ "species_10588958" ], "modifiers": [ [ "species_10588954", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0288453", "Q54IY4", "DDB_G0288453", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0288453" ] }, "reaction_10588963": { "compartment": "compartment_70101", "id": "reaction_10588963", "reactome": "R-DDI-264458", "name": "Proteasome mediated degradation of COP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10588958" ], "products": [ "species_10577037" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q54IY4", "DDB_G0288453", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10588956": { "compartment": "compartment_13231", "id": "reaction_10588956", "reactome": "R-DDI-264418", "name": "Translocation of COP1 from the nucleus to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10588952" ], "products": [ "species_10588954" ], "modifiers": [], "additional_components": [ "DDB_G0288453", "DDB_G0288453" ] }, "reaction_10591483": { "compartment": "compartment_7660", "id": "reaction_10591483", "reactome": "R-DDI-427514", "name": "eNoSC deacetylates histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10591466", "species_427523" ], "products": [ "species_427497", "species_427498", "species_10588889" ], "modifiers": [ [ "species_10591480", "catalyst" ] ], "additional_components": [ "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863", "O15819", "DDB_G0267402", "Q54F38", "DDB_G0291185", "Q76NW2", "DDB_G0276863", "Q54CP1", "DDB_G0292960", "Q54GV7", "DDB_G0289967", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863" ] }, "reaction_10591486": { "compartment": "compartment_7660", "id": "reaction_10591486", "reactome": "R-DDI-427527", "name": "eNoSC dimethylates histone H3 at lysine-9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10588889" ], "products": [ "species_77502", "species_10581485" ], "modifiers": [ [ "species_10591480", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "Q54F38", "DDB_G0291185", "Q76NW2", "DDB_G0276863", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863", "Q54CP1", "DDB_G0292960", "Q54GV7", "DDB_G0289967", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863" ] }, "reaction_10596528": { "compartment": "compartment_70101", "id": "reaction_10596528", "reactome": "R-DDI-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10596521" ], "products": [ "species_111294", "species_10596525", "species_10596517", "species_76577" ], "modifiers": [ [ "species_10596448", "catalyst" ] ], "additional_components": [ "Q54ZG5", "DDB_G0277577", "O60999", "DDB_G0291972", "Q75JS0", "DDB_G0272202", "C7G034", "DDB_G0285063", "Q54E43", "DDB_G0291812", "Q557Q0", "DDB_G0291812", "Q55GE4", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q557G6", "DDB_G0291812", "C7G038", "DDB_G0291812", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54JE9", "DDB_G0292128", "Q54QZ3", "DDB_G0292128", "Q75JM9", "DDB_G0292128", "Q54DM4", "DDB_G0292128", "Q54JT8", "DDB_G0292128", "Q54JV0", "DDB_G0292128", "Q54IW6", "DDB_G0292128", "Q54LZ6", "DDB_G0286289", "Q55AE0", "DDB_G0285763", "Q54MZ0", "DDB_G0285763", "Q54PV3", "DDB_G0285763", "Q54TL7", "DDB_G0281679", "Q54KP2", "DDB_G0287221", "Q54GG5", "DDB_G0290179", "Q54QF1", "DDB_G0283983", "Q54XF1", "DDB_G0279003", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q553F3", "DDB_G0275787", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54ZG5", "DDB_G0277577", "O60999", "DDB_G0291972", "Q75JS0", "DDB_G0272202", "C7G034", "DDB_G0285063", "Q54E43", "DDB_G0291812", "Q557Q0", "DDB_G0291812", "Q55GE4", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q557G6", "DDB_G0291812", "C7G038", "DDB_G0291812", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54JE9", "DDB_G0292128", "Q54QZ3", "DDB_G0292128", "Q75JM9", "DDB_G0292128", "Q54DM4", "DDB_G0292128", "Q54JT8", "DDB_G0292128", "Q54JV0", "DDB_G0292128", "Q54IW6", "DDB_G0292128", "Q54LZ6", "DDB_G0286289", "Q55AE0", "DDB_G0285763", "Q54MZ0", "DDB_G0285763", "Q54PV3", "DDB_G0285763", "Q54TL7", "DDB_G0281679", "Q54KP2", "DDB_G0287221", "Q54GG5", "DDB_G0290179", "Q54QF1", "DDB_G0283983", "Q54XF1", "DDB_G0279003", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q553F3", "DDB_G0275787", "Q54ZG5", "DDB_G0277577", "O60999", "DDB_G0291972", "Q75JS0", "DDB_G0272202", "C7G034", "DDB_G0285063", "Q54E43", "DDB_G0291812", "Q557Q0", "DDB_G0291812", "Q55GE4", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q557G6", "DDB_G0291812", "C7G038", "DDB_G0291812", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54JE9", "DDB_G0292128", "Q54QZ3", "DDB_G0292128", "Q75JM9", "DDB_G0292128", "Q54DM4", "DDB_G0292128", "Q54JT8", "DDB_G0292128", "Q54JV0", "DDB_G0292128", "Q54IW6", "DDB_G0292128", "Q54LZ6", "DDB_G0286289", "Q55AE0", "DDB_G0285763", "Q54MZ0", "DDB_G0285763", "Q54PV3", "DDB_G0285763", "Q54TL7", "DDB_G0281679", "Q54KP2", "DDB_G0287221", "Q54GG5", "DDB_G0290179", "Q54QF1", "DDB_G0283983", "Q54XF1", "DDB_G0279003", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586" ] }, "reaction_10596579": { "compartment": "compartment_70101", "id": "reaction_10596579", "reactome": "R-DDI-983147", "name": "Release of E3 from polyubiquitinated substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596577" ], "products": [ "species_983123", "species_10596448" ], "modifiers": [], "additional_components": [ "Q54ZG5", "DDB_G0277577", "O60999", "DDB_G0291972", "Q75JS0", "DDB_G0272202", "C7G034", "DDB_G0285063", "Q54E43", "DDB_G0291812", "Q557Q0", "DDB_G0291812", "Q55GE4", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q557G6", "DDB_G0291812", "C7G038", "DDB_G0291812", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54JE9", "DDB_G0292128", "Q54QZ3", "DDB_G0292128", "Q75JM9", "DDB_G0292128", "Q54DM4", "DDB_G0292128", "Q54JT8", "DDB_G0292128", "Q54JV0", "DDB_G0292128", "Q54IW6", "DDB_G0292128", "Q54LZ6", "DDB_G0286289", "Q55AE0", "DDB_G0285763", "Q54MZ0", "DDB_G0285763", "Q54PV3", "DDB_G0285763", "Q54TL7", "DDB_G0281679", "Q54KP2", "DDB_G0287221", "Q54GG5", "DDB_G0290179", "Q54QF1", "DDB_G0283983", "Q54XF1", "DDB_G0279003", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54ZG5", "DDB_G0277577", "O60999", "DDB_G0291972", "Q75JS0", "DDB_G0272202", "C7G034", "DDB_G0285063", "Q54E43", "DDB_G0291812", "Q557Q0", "DDB_G0291812", "Q55GE4", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q557G6", "DDB_G0291812", "C7G038", "DDB_G0291812", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54JE9", "DDB_G0292128", "Q54QZ3", "DDB_G0292128", "Q75JM9", "DDB_G0292128", "Q54DM4", "DDB_G0292128", "Q54JT8", "DDB_G0292128", "Q54JV0", "DDB_G0292128", "Q54IW6", "DDB_G0292128", "Q54LZ6", "DDB_G0286289", "Q55AE0", "DDB_G0285763", "Q54MZ0", "DDB_G0285763", "Q54PV3", "DDB_G0285763", "Q54TL7", "DDB_G0281679", "Q54KP2", "DDB_G0287221", "Q54GG5", "DDB_G0290179", "Q54QF1", "DDB_G0283983", "Q54XF1", "DDB_G0279003", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586" ] }, "reaction_10596610": { "compartment": "compartment_70101", "id": "reaction_10596610", "reactome": "R-DDI-983152", "name": "Transfer of ubiquitin from E1 to E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596607", "species_10596517" ], "products": [ "species_10596605", "species_10596519" ], "modifiers": [ [ "species_10596517", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q553F3", "DDB_G0275787", "Q553F3", "DDB_G0275787", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q553F3", "DDB_G0275787" ] }, "reaction_10596613": { "compartment": "compartment_70101", "id": "reaction_10596613", "reactome": "R-DDI-983153", "name": "E1 mediated ubiquitin activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596605", "species_10577037", "species_113592", "species_29926" ], "products": [ "species_111294", "species_10596607", "species_29926", "species_76577" ], "modifiers": [ [ "species_10596605", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765" ] }, "reaction_10596581": { "compartment": "compartment_70101", "id": "reaction_10596581", "reactome": "R-DDI-983150", "name": "Proteasomal cleavage of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983123" ], "products": [ "species_10577037", "species_983032", "species_8942986", "species_983036" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10623191": { "compartment": "compartment_70101", "id": "reaction_10623191", "reactome": "R-DDI-8940641", "name": "THOP1 cleaves oligopeptide fragment (8-16aa)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983032" ], "products": [ "species_8955634" ], "modifiers": [ [ "species_10623188", "catalyst" ] ], "additional_components": [ "DDB_G0292362" ] }, "reaction_10596663": { "compartment": "compartment_70101", "id": "reaction_10596663", "reactome": "R-DDI-983162", "name": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983036" ], "products": [ "species_983032", "species_8942986" ], "modifiers": [ [ "species_10596660", "catalyst" ] ], "additional_components": [ "Q557I4", "DDB_G0273419", "Q55CT4", "DDB_G0270994", "Q55CY7", "DDB_G0270670" ] }, "reaction_10596616": { "compartment": "compartment_70101", "id": "reaction_10596616", "reactome": "R-DDI-983156", "name": "Polyubiquitination of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596525", "species_113592", "species_10596519" ], "products": [ "species_111294", "species_10596517", "species_76577", "species_10596577" ], "modifiers": [ [ "species_10596525", "catalyst" ] ], "additional_components": [ "Q54ZG5", "DDB_G0277577", "O60999", "DDB_G0291972", "Q75JS0", "DDB_G0272202", "C7G034", "DDB_G0285063", "Q54E43", "DDB_G0291812", "Q557Q0", "DDB_G0291812", "Q55GE4", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q557G6", "DDB_G0291812", "C7G038", "DDB_G0291812", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54JE9", "DDB_G0292128", "Q54QZ3", "DDB_G0292128", "Q75JM9", "DDB_G0292128", "Q54DM4", "DDB_G0292128", "Q54JT8", "DDB_G0292128", "Q54JV0", "DDB_G0292128", "Q54IW6", "DDB_G0292128", "Q54LZ6", "DDB_G0286289", "Q55AE0", "DDB_G0285763", "Q54MZ0", "DDB_G0285763", "Q54PV3", "DDB_G0285763", "Q54TL7", "DDB_G0281679", "Q54KP2", "DDB_G0287221", "Q54GG5", "DDB_G0290179", "Q54QF1", "DDB_G0283983", "Q54XF1", "DDB_G0279003", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q553F3", "DDB_G0275787", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q553F3", "DDB_G0275787", "Q54ZG5", "DDB_G0277577", "O60999", "DDB_G0291972", "Q75JS0", "DDB_G0272202", "C7G034", "DDB_G0285063", "Q54E43", "DDB_G0291812", "Q557Q0", "DDB_G0291812", "Q55GE4", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q557G6", "DDB_G0291812", "C7G038", "DDB_G0291812", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54JE9", "DDB_G0292128", "Q54QZ3", "DDB_G0292128", "Q75JM9", "DDB_G0292128", "Q54DM4", "DDB_G0292128", "Q54JT8", "DDB_G0292128", "Q54JV0", "DDB_G0292128", "Q54IW6", "DDB_G0292128", "Q54LZ6", "DDB_G0286289", "Q55AE0", "DDB_G0285763", "Q54MZ0", "DDB_G0285763", "Q54PV3", "DDB_G0285763", "Q54TL7", "DDB_G0281679", "Q54KP2", "DDB_G0287221", "Q54GG5", "DDB_G0290179", "Q54QF1", "DDB_G0283983", "Q54XF1", "DDB_G0279003", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54ZG5", "DDB_G0277577", "O60999", "DDB_G0291972", "Q75JS0", "DDB_G0272202", "C7G034", "DDB_G0285063", "Q54E43", "DDB_G0291812", "Q557Q0", "DDB_G0291812", "Q55GE4", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q557G6", "DDB_G0291812", "C7G038", "DDB_G0291812", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54JE9", "DDB_G0292128", "Q54QZ3", "DDB_G0292128", "Q75JM9", "DDB_G0292128", "Q54DM4", "DDB_G0292128", "Q54JT8", "DDB_G0292128", "Q54JV0", "DDB_G0292128", "Q54IW6", "DDB_G0292128", "Q54LZ6", "DDB_G0286289", "Q55AE0", "DDB_G0285763", "Q54MZ0", "DDB_G0285763", "Q54PV3", "DDB_G0285763", "Q54TL7", "DDB_G0281679", "Q54KP2", "DDB_G0287221", "Q54GG5", "DDB_G0290179", "Q54QF1", "DDB_G0283983", "Q54XF1", "DDB_G0279003", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765" ] }, "reaction_10596618": { "compartment": "compartment_70101", "id": "reaction_10596618", "reactome": "R-DDI-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596519", "species_983035", "species_10596448" ], "products": [ "species_10596521" ], "modifiers": [], "additional_components": [ "Q553F3", "DDB_G0275787", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54ZG5", "DDB_G0277577", "O60999", "DDB_G0291972", "Q75JS0", "DDB_G0272202", "C7G034", "DDB_G0285063", "Q54E43", "DDB_G0291812", "Q557Q0", "DDB_G0291812", "Q55GE4", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q557G6", "DDB_G0291812", "C7G038", "DDB_G0291812", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54JE9", "DDB_G0292128", "Q54QZ3", "DDB_G0292128", "Q75JM9", "DDB_G0292128", "Q54DM4", "DDB_G0292128", "Q54JT8", "DDB_G0292128", "Q54JV0", "DDB_G0292128", "Q54IW6", "DDB_G0292128", "Q54LZ6", "DDB_G0286289", "Q55AE0", "DDB_G0285763", "Q54MZ0", "DDB_G0285763", "Q54PV3", "DDB_G0285763", "Q54TL7", "DDB_G0281679", "Q54KP2", "DDB_G0287221", "Q54GG5", "DDB_G0290179", "Q54QF1", "DDB_G0283983", "Q54XF1", "DDB_G0279003", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54ZG5", "DDB_G0277577", "O60999", "DDB_G0291972", "Q75JS0", "DDB_G0272202", "C7G034", "DDB_G0285063", "Q54E43", "DDB_G0291812", "Q557Q0", "DDB_G0291812", "Q55GE4", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q557G6", "DDB_G0291812", "C7G038", "DDB_G0291812", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54JE9", "DDB_G0292128", "Q54QZ3", "DDB_G0292128", "Q75JM9", "DDB_G0292128", "Q54DM4", "DDB_G0292128", "Q54JT8", "DDB_G0292128", "Q54JV0", "DDB_G0292128", "Q54IW6", "DDB_G0292128", "Q54LZ6", "DDB_G0286289", "Q55AE0", "DDB_G0285763", "Q54MZ0", "DDB_G0285763", "Q54PV3", "DDB_G0285763", "Q54TL7", "DDB_G0281679", "Q54KP2", "DDB_G0287221", "Q54GG5", "DDB_G0290179", "Q54QF1", "DDB_G0283983", "Q54XF1", "DDB_G0279003", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q553F3", "DDB_G0275787", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765" ] }, "reaction_10596569": { "compartment": "compartment_17957", "id": "reaction_10596569", "reactome": "R-DDI-983144", "name": "Transport of Antigen peptide in to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_983032" ], "products": [ "species_29372", "species_29370", "species_983034" ], "modifiers": [ [ "species_10596566", "catalyst" ] ], "additional_components": [ "Q54BU4", "DDB_G0293416", "Q8T9W1", "DDB_G0286123", "P54683", "DDB_G0286119", "Q23868", "DDB_G0286121" ] }, "reaction_10596648": { "compartment": "compartment_17957", "id": "reaction_10596648", "reactome": "R-DDI-983158", "name": "Trimming of peptides in ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983034" ], "products": [ "species_8943716", "species_983033" ], "modifiers": [ [ "species_10596645", "catalyst" ] ], "additional_components": [ "Q55CY7", "DDB_G0270670", "Q557I4", "DDB_G0273419", "Q55CT4", "DDB_G0270994" ] }, "reaction_10588094": { "compartment": "compartment_12045", "id": "reaction_10588094", "reactome": "R-DDI-203979", "name": "Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587919", "species_10588090" ], "products": [ "species_10588092" ], "modifiers": [], "additional_components": [ "Q559R0", "DDB_G0272296", "species_29438", "Q54T59", "DDB_G0281985", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q559R0", "DDB_G0272296", "species_29438" ] }, "reaction_10597282": { "compartment": "compartment_70101", "id": "reaction_10597282", "reactome": "R-DDI-1236970", "name": "Proteasomal clevage of exogenous antigen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1236719" ], "products": [ "species_8942986", "species_983036" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10583537": { "compartment": "compartment_876", "id": "reaction_10583537", "reactome": "R-DDI-114688", "name": "PLC-beta hydrolyses PIP2 to DAG and IP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583532" ], "products": [ "species_10583534" ], "modifiers": [ [ "species_10582955", "catalyst" ] ], "additional_components": [ "species_179856", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438", "Q02158", "DDB_G0292736", "species_6797635", "species_114520", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438", "Q02158", "DDB_G0292736", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438", "Q02158", "DDB_G0292736" ] }, "reaction_10624320": { "compartment": "compartment_876", "id": "reaction_10624320", "reactome": "R-DDI-8982026", "name": "G alpha (q):RGS dissociates to inactive G alpha (q)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624315" ], "products": [ "species_10590812", "species_10624295" ], "modifiers": [], "additional_components": [ "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29420", "species_29420", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817" ] }, "reaction_10590869": { "compartment": "compartment_876", "id": "reaction_10590869", "reactome": "R-DDI-418582", "name": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582953" ], "products": [ "species_10590812" ], "modifiers": [ [ "species_10582953", "catalyst" ], [ "species_10590867", "catalyst" ] ], "additional_components": [ "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438", "species_29420", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438", "Q55E55", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817" ] }, "reaction_10624299": { "compartment": "compartment_876", "id": "reaction_10624299", "reactome": "R-DDI-8982017", "name": "Active G alpha (q) binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582953", "species_10624295" ], "products": [ "species_10624297" ], "modifiers": [], "additional_components": [ "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438", "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438" ] }, "reaction_10583555": { "compartment": "compartment_70101", "id": "reaction_10583555", "reactome": "R-DDI-139941", "name": "Binding of IP3 to IP3 receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583548", "species_114520" ], "products": [ "species_10583550" ], "modifiers": [], "additional_components": [ "Q9NA13", "DDB_G0292564", "species_114520", "species_74112", "Q9NA13", "DDB_G0292564" ] }, "reaction_10591430": { "compartment": "compartment_876", "id": "reaction_10591430", "reactome": "R-DDI-426032", "name": "DAG is metabolized by DAGL to 2-AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114519" ], "products": [ "species_426026", "species_426030" ], "modifiers": [ [ "species_10591427", "catalyst" ] ], "additional_components": [ "Q54ET1", "DDB_G0291354", "Q54GX3", "DDB_G0291354", "Q54YL1", "DDB_G0291354" ] }, "reaction_10591452": { "compartment": "compartment_70101", "id": "reaction_10591452", "reactome": "R-DDI-426240", "name": "DAG kinase produces phosphatidic acid from DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_114519" ], "products": [ "species_76108", "species_29370" ], "modifiers": [ [ "species_10591435", "catalyst" ] ], "additional_components": [ "DDB_G0277223" ] }, "reaction_10624318": { "compartment": "compartment_876", "id": "reaction_10624318", "reactome": "R-DDI-8982025", "name": "G alpha (q) in G (q):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624297" ], "products": [ "species_29372", "species_10624315" ], "modifiers": [ [ "species_10624297", "catalyst" ] ], "additional_components": [ "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438", "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29420", "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438" ] }, "reaction_10580531": { "compartment": "compartment_70101", "id": "reaction_10580531", "reactome": "R-DDI-73616", "name": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_83960", "species_29364" ], "products": [ "species_29366", "species_73541" ], "modifiers": [ [ "species_10580469", "catalyst" ] ], "additional_components": [ "Q55FT1", "DDB_G0267966", "species_76629", "species_113596" ] }, "reaction_10580482": { "compartment": "compartment_70101", "id": "reaction_10580482", "reactome": "R-DDI-73589", "name": "5,6-dihydrouracil + H2O => beta-ureidopropionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73584" ], "products": [ "species_73588" ], "modifiers": [ [ "species_10580479", "catalyst" ] ], "additional_components": [ "species_29426", "Q55DL0", "DDB_G0269246" ] }, "reaction_10580533": { "compartment": "compartment_70101", "id": "reaction_10580533", "reactome": "R-DDI-73618", "name": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73541" ], "products": [ "species_73617" ], "modifiers": [ [ "species_10580479", "catalyst" ] ], "additional_components": [ "species_29426", "Q55DL0", "DDB_G0269246" ] }, "reaction_10580535": { "compartment": "compartment_70101", "id": "reaction_10580535", "reactome": "R-DDI-73620", "name": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73617" ], "products": [ "species_113528", "species_73619", "species_31633" ], "modifiers": [ [ "species_10580489", "catalyst" ] ], "additional_components": [ "species_29426", "Q964D8", "DDB_G0274123" ] }, "reaction_10581240": { "compartment": "compartment_70101", "id": "reaction_10581240", "reactome": "R-DDI-74376", "name": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_500430" ], "products": [ "species_83962", "species_500244" ], "modifiers": [ [ "species_10581235", "catalyst" ] ], "additional_components": [ "CHEBI:16450", "CHEBI:16704", "CHEBI:28542", "species_112016", "Q54PM8", "DDB_G0284431" ] }, "reaction_10580472": { "compartment": "compartment_70101", "id": "reaction_10580472", "reactome": "R-DDI-73585", "name": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_83962", "species_29364" ], "products": [ "species_29366", "species_73584" ], "modifiers": [ [ "species_10580469", "catalyst" ] ], "additional_components": [ "Q55FT1", "DDB_G0267966", "species_76629", "species_113596" ] }, "reaction_10580492": { "compartment": "compartment_70101", "id": "reaction_10580492", "reactome": "R-DDI-73591", "name": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73588" ], "products": [ "species_113528", "species_73590", "species_31633" ], "modifiers": [ [ "species_10580489", "catalyst" ] ], "additional_components": [ "species_29426", "Q964D8", "DDB_G0274123" ] }, "reaction_10623846": { "compartment": "compartment_5460", "id": "reaction_10623846", "reactome": "R-DDI-8952873", "name": "MECR dimer reduces tdec2-CoA to DEC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77343", "species_113529", "species_113600" ], "products": [ "species_77308", "species_113563" ], "modifiers": [ [ "species_10623843", "catalyst" ] ], "additional_components": [ "Q54YT4", "DDB_G0278095" ] }, "reaction_10582430": { "compartment": "compartment_5460", "id": "reaction_10582430", "reactome": "R-DDI-77344", "name": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77343", "species_113521" ], "products": [ "species_77341" ], "modifiers": [ [ "species_10578064", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10586368": { "compartment": "compartment_876", "id": "reaction_10586368", "reactome": "R-DDI-190519", "name": "Internalization of gap junction plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10586270", "species_10586248" ], "products": [ "species_10586366" ], "modifiers": [], "additional_components": [ "P54697", "DDB_G0272112", "Q9TW28", "DDB_G0292262", "P54696", "DDB_G0289447", "Q9U1M8", "DDB_G0274455", "P54672", "DDB_G0277139", "P54672", "DDB_G0277139", "P54696", "DDB_G0289447", "P54697", "DDB_G0272112", "Q9TW28", "DDB_G0292262", "Q9U1M8", "DDB_G0274455" ] }, "reaction_10586370": { "compartment": "compartment_70101", "id": "reaction_10586370", "reactome": "R-DDI-190829", "name": "Lysosomal degradation of gap junction plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10586366" ], "products": [], "modifiers": [], "additional_components": [ "P54672", "DDB_G0277139", "P54696", "DDB_G0289447", "P54697", "DDB_G0272112", "Q9TW28", "DDB_G0292262", "Q9U1M8", "DDB_G0274455" ] }, "reaction_10586762": { "compartment": "compartment_876", "id": "reaction_10586762", "reactome": "R-DDI-196017", "name": "Dynamin is recruited to the gap junction plaque", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10586246", "species_10586226" ], "products": [ "species_10586248" ], "modifiers": [], "additional_components": [ "P54672", "DDB_G0277139", "P54672", "DDB_G0277139" ] }, "reaction_10576483": { "compartment": "compartment_7660", "id": "reaction_10576483", "reactome": "R-DDI-68603", "name": "Orc5 associates with Orc3:Orc2:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576479", "species_10576472" ], "products": [ "species_10576481" ], "modifiers": [], "additional_components": [ "DDB_G0293214", "Q55CU7", "DDB_G0269894", "Q55BR6", "DDB_G0271078", "Q55CU7", "DDB_G0269894", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214" ] }, "reaction_10576501": { "compartment": "compartment_7660", "id": "reaction_10576501", "reactome": "R-DDI-68611", "name": "Orc1 associates with Orc4:Orc5:Orc3:Orc2:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576490", "species_10576497" ], "products": [ "species_10576499" ], "modifiers": [], "additional_components": [ "Q55CU7", "DDB_G0269894", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "Q86AD6", "DDB_G0271562", "DDB_G0283073", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "Q86AD6", "DDB_G0271562" ] }, "reaction_10576474": { "compartment": "compartment_7660", "id": "reaction_10576474", "reactome": "R-DDI-68595", "name": "Orc3 associates with Orc2 constitutively bound at origins of replication", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576463", "species_10576470" ], "products": [ "species_10576472" ], "modifiers": [], "additional_components": [ "DDB_G0271078", "Q55CU7", "DDB_G0269894", "Q55CU7", "DDB_G0269894", "Q55BR6", "DDB_G0271078" ] }, "reaction_10576492": { "compartment": "compartment_7660", "id": "reaction_10576492", "reactome": "R-DDI-68610", "name": "Orc4 associates with Orc5:Orc3:Orc2:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576488", "species_10576481" ], "products": [ "species_10576490" ], "modifiers": [], "additional_components": [ "DDB_G0271562", "Q55CU7", "DDB_G0269894", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "Q55CU7", "DDB_G0269894", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "Q86AD6", "DDB_G0271562" ] }, "reaction_10576510": { "compartment": "compartment_7660", "id": "reaction_10576510", "reactome": "R-DDI-68615", "name": "Orc6 associates with Orc1:Orc4:Orc5:Orc3:Orc2:origin complexes, forming ORC:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576506", "species_10576499" ], "products": [ "species_10576508" ], "modifiers": [], "additional_components": [ "DDB_G0284771", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "Q86AD6", "DDB_G0271562", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q86AD6", "DDB_G0271562", "Q54P62", "DDB_G0284771", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214" ] }, "reaction_10600374": { "compartment": "compartment_876", "id": "reaction_10600374", "reactome": "R-DDI-2142859", "name": "Growing HA is extruded from the cell by ABCC5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142896" ], "products": [ "species_2160848" ], "modifiers": [ [ "species_10597751", "catalyst" ] ], "additional_components": [ "species_2162224", "species_2162224", "Q54V86", "DDB_G0280539", "Q8T6H3", "DDB_G0287593", "Q54EK2", "DDB_G0291243", "Q8T6H8", "DDB_G0280541", "Q54K24", "DDB_G0287589", "Q54VC1", "DDB_G0280459", "Q54VJ0", "DDB_G0280055", "Q54NL1", "DDB_G0285165" ] }, "reaction_10611339": { "compartment": "compartment_984", "id": "reaction_10611339", "reactome": "R-DDI-5693356", "name": "CEMIP hydrolyses HA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2160848" ], "products": [ "species_5693343", "species_2160848" ], "modifiers": [ [ "species_10611336", "catalyst" ] ], "additional_components": [ "species_2162224", "species_2162224", "Q54KF6", "DDB_G0287365", "Q55D62", "DDB_G0287365" ] }, "reaction_10616531": { "compartment": "compartment_7660", "id": "reaction_10616531", "reactome": "R-DDI-6802973", "name": "PLK3 phosphorylates CDC25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10581492" ], "products": [ "species_113582", "species_10616519" ], "modifiers": [ [ "species_10616528", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "Q54BR8", "DDB_G0293470", "Q86HN7", "DDB_G0274503" ] }, "reaction_10613702": { "compartment": "compartment_70101", "id": "reaction_10613702", "reactome": "R-DDI-6798044", "name": "BTG2 binds CCR4-NOT complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613698", "species_10613634" ], "products": [ "species_10613700" ], "modifiers": [], "additional_components": [ "Q554L0", "DDB_G0275005", "Q55D59", "DDB_G0269778", "Q54HH3", "DDB_G0289461", "Q54PZ4", "DDB_G0285269", "Q54NG7", "DDB_G0285269", "Q1ZXI2", "DDB_G0279005", "Q75JL4", "DDB_G0276029", "Q54U17", "DDB_G0281363", "Q54PG2", "DDB_G0284577", "Q55AA8", "DDB_G0272056", "DDB_G0285069", "Q54NU5", "DDB_G0285069", "Q554L0", "DDB_G0275005", "Q55D59", "DDB_G0269778", "Q54HH3", "DDB_G0289461", "Q54PZ4", "DDB_G0285269", "Q54NG7", "DDB_G0285269", "Q1ZXI2", "DDB_G0279005", "Q75JL4", "DDB_G0276029", "Q54U17", "DDB_G0281363", "Q54PG2", "DDB_G0284577", "Q55AA8", "DDB_G0272056" ] }, "reaction_10616032": { "compartment": "compartment_70101", "id": "reaction_10616032", "reactome": "R-DDI-6799722", "name": "TP53I3 oxidoreductase generates unstable semiquinones", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_6799725", "species_29364" ], "products": [ "species_6799726", "species_29366" ], "modifiers": [ [ "species_10615972", "catalyst" ] ], "additional_components": [ "Q75JT6", "DDB_G0272440" ] }, "reaction_10616466": { "compartment": "compartment_876", "id": "reaction_10616466", "reactome": "R-DDI-6801101", "name": "RABGGTA binds RABGGTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616462", "species_10616457" ], "products": [ "species_10616464" ], "modifiers": [], "additional_components": [ "DDB_G0290671", "DDB_G0269570", "Q55DQ4", "DDB_G0269570", "B0G172", "DDB_G0290671" ] }, "reaction_10615974": { "compartment": "compartment_70101", "id": "reaction_10615974", "reactome": "R-DDI-6799466", "name": "TP53I3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615970" ], "products": [ "species_10615972" ], "modifiers": [], "additional_components": [ "DDB_G0272440", "Q75JT6", "DDB_G0272440" ] }, "reaction_10616475": { "compartment": "compartment_70101", "id": "reaction_10616475", "reactome": "R-DDI-6801109", "name": "CHM binds RGGT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616471", "species_10616464" ], "products": [ "species_10616473" ], "modifiers": [], "additional_components": [ "DDB_G0280143", "Q55DQ4", "DDB_G0269570", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "B0G172", "DDB_G0290671", "Q54VT9", "DDB_G0280143" ] }, "reaction_10616445": { "compartment": "compartment_70101", "id": "reaction_10616445", "reactome": "R-DDI-6800793", "name": "PIDD1 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616441" ], "products": [ "species_10616443" ], "modifiers": [], "additional_components": [ "DDB_G0284461", "DDB_G0284461" ] }, "reaction_10616491": { "compartment": "compartment_17927", "id": "reaction_10616491", "reactome": "R-DDI-6801242", "name": "TRIAP1 binds PRELID1, PRELID3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616485", "species_10616480" ], "products": [ "species_10616489" ], "modifiers": [], "additional_components": [ "DDB_G0290499", "DDB_G0287279", "Q54KL1", "DDB_G0287279", "Q54G07", "DDB_G0290499" ] }, "reaction_10616494": { "compartment": "compartment_17906", "id": "reaction_10616494", "reactome": "R-DDI-6801250", "name": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500590" ], "products": [ "species_1524101" ], "modifiers": [ [ "species_10616489", "catalyst" ] ], "additional_components": [ "Q54KL1", "DDB_G0287279", "Q54G07", "DDB_G0290499" ] }, "reaction_10613581": { "compartment": "compartment_7660", "id": "reaction_10613581", "reactome": "R-DDI-6797606", "name": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10613565" ], "products": [ "species_113582", "species_10613578" ], "modifiers": [ [ "species_10613565", "catalyst" ] ], "additional_components": [ "Q54LJ0", "DDB_G0286617", "Q75JA4", "DDB_G0271690", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q556Z2", "DDB_G0273207", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54LJ0", "DDB_G0286617", "Q75JA4", "DDB_G0271690", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q556Z2", "DDB_G0273207", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54LJ0", "DDB_G0286617", "Q75JA4", "DDB_G0271690", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q556Z2", "DDB_G0273207", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10613541": { "compartment": "compartment_70101", "id": "reaction_10613541", "reactome": "R-DDI-6795290", "name": "TORC2 complex phosphorylates SGK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613531", "species_113592" ], "products": [ "species_29370", "species_10613539" ], "modifiers": [ [ "species_10587023", "catalyst" ] ], "additional_components": [ "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54D08", "DDB_G0292592", "O77203", "DDB_G0277399", "Q9Y0C9", "DDB_G0284611", "Q86C65", "DDB_G0281569" ] }, "reaction_10613551": { "compartment": "compartment_70101", "id": "reaction_10613551", "reactome": "R-DDI-6795473", "name": "PDPK1 phosphorylates SGK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10613539" ], "products": [ "species_10613549", "species_29370" ], "modifiers": [ [ "species_10582584", "catalyst" ] ], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10577717": { "compartment": "compartment_70101", "id": "reaction_10577717", "reactome": "R-DDI-70377", "name": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30537", "species_29366" ], "products": [ "species_70106", "species_31467", "species_29364" ], "modifiers": [ [ "species_10577714", "catalyst" ] ], "additional_components": [ "species_29366", "Q557D2", "DDB_G0273131" ] }, "reaction_10605925": { "compartment": "compartment_70101", "id": "reaction_10605925", "reactome": "R-DDI-5631885", "name": "PRDX1 overoxidizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605917", "species_29408" ], "products": [ "species_29356", "species_10605922" ], "modifiers": [ [ "species_10605917", "catalyst" ] ], "additional_components": [ "Q555L5", "DDB_G0274859", "Q555L5", "DDB_G0274859", "Q555L5", "DDB_G0274859" ] }, "reaction_10605942": { "compartment": "compartment_70101", "id": "reaction_10605942", "reactome": "R-DDI-5631903", "name": "SESN1,2,3 bind overoxidized PRDX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605922", "species_10605938" ], "products": [ "species_10605940" ], "modifiers": [], "additional_components": [ "Q555L5", "DDB_G0274859", "Q54WU6", "DDB_G0279427", "Q54WU6", "DDB_G0279427", "Q555L5", "DDB_G0274859" ] }, "reaction_10578681": { "compartment": "compartment_70101", "id": "reaction_10578681", "reactome": "R-DDI-71682", "name": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_111745" ], "products": [ "species_29450", "species_29366" ], "modifiers": [ [ "species_10578678", "catalyst" ] ], "additional_components": [ "Q8T137", "DDB_G0272754", "species_113596" ] }, "reaction_10589979": { "compartment": "compartment_70101", "id": "reaction_10589979", "reactome": "R-DDI-380979", "name": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584242" ], "products": [ "species_29372", "species_10589976" ], "modifiers": [ [ "species_10584242", "catalyst" ] ], "additional_components": [ "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318" ] }, "reaction_10586987": { "compartment": "compartment_70101", "id": "reaction_10586987", "reactome": "R-DDI-198609", "name": "AKT phosphorylates TSC2, inhibiting it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584141", "species_113592" ], "products": [ "species_29370", "species_10586984" ], "modifiers": [ [ "species_10586959", "catalyst" ] ], "additional_components": [ "DDB_G0280527", "DDB_G0280527", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795" ] }, "reaction_10605946": { "compartment": "compartment_70101", "id": "reaction_10605946", "reactome": "R-DDI-5631941", "name": "SESN1,2,3 bind AMPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589958", "species_10605938" ], "products": [ "species_10605944" ], "modifiers": [], "additional_components": [ "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "Q54WU6", "DDB_G0279427", "Q54WU6", "DDB_G0279427", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643" ] }, "reaction_10624930": { "compartment": "compartment_5460", "id": "reaction_10624930", "reactome": "R-DDI-9013198", "name": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614595", "species_9013199" ], "products": [ "species_9013207", "species_9013191" ], "modifiers": [ [ "species_10624637", "catalyst" ] ], "additional_components": [ "DDB_G0291816" ] }, "reaction_10617891": { "compartment": "compartment_70101", "id": "reaction_10617891", "reactome": "R-DDI-6814153", "name": "ADO oxidises 2AET to HTAU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_6814151" ], "products": [ "species_1655445", "species_70106" ], "modifiers": [ [ "species_10617888", "catalyst" ] ], "additional_components": [ "species_71067", "Q556I2", "DDB_G0273031" ] }, "reaction_10624640": { "compartment": "compartment_5460", "id": "reaction_10624640", "reactome": "R-DDI-9012721", "name": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9012724", "species_9012592" ], "products": [ "species_1614595", "species_113557" ], "modifiers": [ [ "species_10624637", "catalyst" ] ], "additional_components": [ "DDB_G0291816" ] }, "reaction_10598498": { "compartment": "compartment_70101", "id": "reaction_10598498", "reactome": "R-DDI-1614645", "name": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_29368" ], "products": [ "species_1614519" ], "modifiers": [ [ "species_10598495", "catalyst" ] ], "additional_components": [ "species_71067", "Q54K68", "DDB_G0287555" ] }, "reaction_10624934": { "compartment": "compartment_5460", "id": "reaction_10624934", "reactome": "R-DDI-9013533", "name": "MPST transfers sulfur from sulfanegen to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9013543", "species_9013199" ], "products": [ "species_9013191", "species_113557" ], "modifiers": [ [ "species_10624637", "catalyst" ] ], "additional_components": [ "DDB_G0291816" ] }, "reaction_10624932": { "compartment": "compartment_5460", "id": "reaction_10624932", "reactome": "R-DDI-9013471", "name": "MPST transfers sulfur from 3MPYR to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9012592", "species_9013199" ], "products": [ "species_9013191", "species_113557" ], "modifiers": [ [ "species_10624637", "catalyst" ] ], "additional_components": [ "DDB_G0291816" ] }, "reaction_10598477": { "compartment": "compartment_70101", "id": "reaction_10598477", "reactome": "R-DDI-1614567", "name": "Excess homocysteine yields homolanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369" ], "products": [ "species_1614532", "species_1614594" ], "modifiers": [ [ "species_10598474", "catalyst" ], [ "species_174369", "catalyst" ] ], "additional_components": [ "Q55DV9", "DDB_G0269122" ] }, "reaction_10625805": { "compartment": "compartment_5460", "id": "reaction_10625805", "reactome": "R-DDI-9034756", "name": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624637", "species_9012592" ], "products": [ "species_10625803", "species_113557" ], "modifiers": [ [ "species_10624637", "catalyst" ] ], "additional_components": [ "DDB_G0291816", "DDB_G0291816", "DDB_G0291816" ] }, "reaction_10625811": { "compartment": "compartment_5460", "id": "reaction_10625811", "reactome": "R-DDI-9035484", "name": "CysS248-MPST:TXN2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625807" ], "products": [ "species_10624637", "species_10602636", "species_1655881" ], "modifiers": [], "additional_components": [ "Q54NX3", "DDB_G0284939", "Q54E40", "DDB_G0291816", "DDB_G0291816", "DDB_G0284939" ] }, "reaction_10598483": { "compartment": "compartment_70101", "id": "reaction_10598483", "reactome": "R-DDI-1614591", "name": "Excess cysteine yields lanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707" ], "products": [ "species_1614582", "species_1614532" ], "modifiers": [ [ "species_10598474", "catalyst" ], [ "species_111707", "catalyst" ] ], "additional_components": [ "Q55DV9", "DDB_G0269122" ] }, "reaction_10625809": { "compartment": "compartment_5460", "id": "reaction_10625809", "reactome": "R-DDI-9035227", "name": "TXN2 binds CysS248-MPST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625803", "species_10602633" ], "products": [ "species_10625807" ], "modifiers": [], "additional_components": [ "DDB_G0291816", "DDB_G0284939", "Q54NX3", "DDB_G0284939", "Q54E40", "DDB_G0291816" ] }, "reaction_10598485": { "compartment": "compartment_70101", "id": "reaction_10598485", "reactome": "R-DDI-1614614", "name": "Cysteine is degraded to serine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111707" ], "products": [ "species_1614532", "species_200736" ], "modifiers": [ [ "species_10598474", "catalyst" ] ], "additional_components": [ "Q55DV9", "DDB_G0269122" ] }, "reaction_10598488": { "compartment": "compartment_70101", "id": "reaction_10598488", "reactome": "R-DDI-1614631", "name": "Homocysteine is degraded to oxobutanoate and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_174369" ], "products": [ "species_1614532", "species_29382", "species_936714" ], "modifiers": [ [ "species_10598474", "catalyst" ] ], "additional_components": [ "Q55DV9", "DDB_G0269122" ] }, "reaction_10598464": { "compartment": "compartment_5460", "id": "reaction_10598464", "reactome": "R-DDI-1614544", "name": "Sulfite is oxidized to sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_1614538", "species_113521" ], "products": [ "species_1614617", "species_1614584" ], "modifiers": [ [ "species_10598461", "catalyst" ] ], "additional_components": [ "Q54XJ8", "DDB_G0278893", "species_947539" ] }, "reaction_10598466": { "compartment": "compartment_70616", "id": "reaction_10598466", "reactome": "R-DDI-1614546", "name": "Sulfate is exported to the cytosol in exchange for dicarboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198498", "species_1614584" ], "products": [ "species_113544", "species_174375" ], "modifiers": [ [ "species_10589601", "catalyst" ] ], "additional_components": [ "DDB_G0284225" ] }, "reaction_10599916": { "compartment": "compartment_70101", "id": "reaction_10599916", "reactome": "R-DDI-2028626", "name": "Phosphorylated MOB1A proteins associate with LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599890", "species_10599858" ], "products": [ "species_10599892" ], "modifiers": [], "additional_components": [ "Q54BM4", "DDB_G0293706", "Q54CR8", "DDB_G0292758", "Q54XJ0", "DDB_G0278907", "Q54QV0", "DDB_G0283625", "Q1ZXI5", "DDB_G0278845", "Q54HD2", "DDB_G0289543", "Q54P47", "DDB_G0284839", "Q1ZXI5", "DDB_G0278845", "Q54HD2", "DDB_G0289543", "Q54P47", "DDB_G0284839", "Q54BM4", "DDB_G0293706", "Q54CR8", "DDB_G0292758", "Q54XJ0", "DDB_G0278907", "Q54QV0", "DDB_G0283625" ] }, "reaction_10624545": { "compartment": "compartment_5460", "id": "reaction_10624545", "reactome": "R-DDI-9011595", "name": "GSTZ1 dimer dehalogenates DCA to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9010792", "species_113521" ], "products": [ "species_904849", "species_3301973" ], "modifiers": [ [ "species_10624542", "catalyst" ], [ "species_1655887", "catalyst" ], [ "species_9010792", "inhibitor" ] ], "additional_components": [ "species_29450", "Q54YN2", "DDB_G0278155" ] }, "reaction_10583891": { "compartment": "compartment_12045", "id": "reaction_10583891", "reactome": "R-DDI-162721", "name": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449299" ], "products": [ "species_29420", "species_162681" ], "modifiers": [ [ "species_10583888", "catalyst" ] ], "additional_components": [ "Q54LP3", "DDB_G0286519", "Q556K9", "DDB_G0272588", "Q76NT6", "DDB_G0277435" ] }, "reaction_10611745": { "compartment": "compartment_13959", "id": "reaction_10611745", "reactome": "R-DDI-5694439", "name": "COPII coat binds TRAPPCII and RAB1:GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10588070", "species_10611620", "species_10611571" ], "products": [ "species_10611622" ], "modifiers": [], "additional_components": [ "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q559Q3", "DDB_G0272298", "Q54J84", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54VR1", "DDB_G0288221", "Q8T2J5", "DDB_G0271968", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q55CT5", "DDB_G0270992", "Q54DS8", "DDB_G0292052", "Q54EA5", "DDB_G0291694", "Q55CR0", "DDB_G0269942", "Q54UU1", "DDB_G0280827", "Q54TK7", "DDB_G0281693", "Q54RV6", "DDB_G0282887", "Q54CU7", "DDB_G0292690", "Q54YG5", "DDB_G0278643", "Q557G3", "DDB_G0273467", "Q555X3", "DDB_G0274803", "Q556Z3", "DDB_G0273209", "Q86K94", "DDB_G0277135", "P34139", "DDB_G0283757", "species_29420", "P34139", "DDB_G0283757", "species_29420", "Q54UU1", "DDB_G0280827", "Q54TK7", "DDB_G0281693", "Q54RV6", "DDB_G0282887", "Q54CU7", "DDB_G0292690", "Q54YG5", "DDB_G0278643", "Q557G3", "DDB_G0273467", "Q555X3", "DDB_G0274803", "Q556Z3", "DDB_G0273209", "Q86K94", "DDB_G0277135", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q559Q3", "DDB_G0272298", "Q54J84", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54VR1", "DDB_G0288221", "Q8T2J5", "DDB_G0271968", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q55CT5", "DDB_G0270992", "Q54DS8", "DDB_G0292052", "Q54EA5", "DDB_G0291694", "Q55CR0", "DDB_G0269942" ] }, "reaction_10588096": { "compartment": "compartment_12045", "id": "reaction_10588096", "reactome": "R-DDI-204008", "name": "SEC31:SEC13 and v-SNARE recruitment", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587867", "species_10587880", "species_10588000" ], "products": [ "species_10588002" ], "modifiers": [], "additional_components": [ "Q54DS8", "DDB_G0292052", "Q55CT5", "DDB_G0270992", "Q54EA5", "DDB_G0291694", "Q55CR0", "DDB_G0269942", "Q55BR0", "DDB_G0269198", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54J84", "DDB_G0288221", "Q559Q3", "DDB_G0272298", "Q559R0", "DDB_G0272296", "species_29438", "Q55BR0", "DDB_G0269198", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54J84", "DDB_G0288221", "Q559Q3", "DDB_G0272298", "Q559R0", "DDB_G0272296", "species_29438", "Q55CR0", "DDB_G0269942", "Q54DS8", "DDB_G0292052", "Q55CT5", "DDB_G0270992", "Q54EA5", "DDB_G0291694" ] }, "reaction_10588082": { "compartment": "compartment_70101", "id": "reaction_10588082", "reactome": "R-DDI-203977", "name": "SAR1 Activation And Membrane Binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10588074" ], "products": [ "species_10587919", "species_29420" ], "modifiers": [ [ "species_10588079", "catalyst" ] ], "additional_components": [ "Q559R0", "DDB_G0272296", "species_29420", "Q559R0", "DDB_G0272296", "species_29438", "DDB_G0286167" ] }, "reaction_10611842": { "compartment": "compartment_70101", "id": "reaction_10611842", "reactome": "R-DDI-5694527", "name": "Loss of SAR1B GTPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587994" ], "products": [ "species_29372", "species_10588090", "species_10588074", "species_10587992" ], "modifiers": [ [ "species_10587994", "catalyst" ] ], "additional_components": [ "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54J84", "DDB_G0288221", "Q559Q3", "DDB_G0272298", "Q559R0", "DDB_G0272296", "species_29438", "Q54T59", "DDB_G0281985", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q559R0", "DDB_G0272296", "species_29420", "Q54T59", "DDB_G0281985", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q54Z72", "DDB_G0277797", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54J84", "DDB_G0288221", "Q559Q3", "DDB_G0272298", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54J84", "DDB_G0288221", "Q559Q3", "DDB_G0272298", "Q559R0", "DDB_G0272296", "species_29438" ] }, "reaction_10618326": { "compartment": "compartment_6791047", "id": "reaction_10618326", "reactome": "R-DDI-6814831", "name": "TBC1D20 binds RAB1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611792", "species_10618322" ], "products": [ "species_10618324" ], "modifiers": [], "additional_components": [ "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "DDB_G0283055", "Q54RT5", "DDB_G0283055", "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736" ] }, "reaction_10611687": { "compartment": "compartment_70101", "id": "reaction_10611687", "reactome": "R-DDI-5694421", "name": "PP6 dephosphorylates SEC24", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10611666" ], "products": [ "species_29372", "species_10588088" ], "modifiers": [ [ "species_10611684", "catalyst" ] ], "additional_components": [ "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q55FM2", "DDB_G0268044", "Q54J43", "DDB_G0288307", "Q9U9A3", "DDB_G0272118" ] }, "reaction_10611800": { "compartment": "compartment_6791047", "id": "reaction_10611800", "reactome": "R-DDI-5694441", "name": "CSNK1D phosphorylates SEC23", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10611760" ], "products": [ "species_29370", "species_10587867", "species_10611766", "species_10611620", "species_10611764", "species_10611666", "species_10611792" ], "modifiers": [ [ "species_10611797", "catalyst" ] ], "additional_components": [ "Q54C46", "DDB_G0293248", "Q54UU1", "DDB_G0280827", "Q54TK7", "DDB_G0281693", "Q54RV6", "DDB_G0282887", "Q54CU7", "DDB_G0292690", "Q54YG5", "DDB_G0278643", "Q557G3", "DDB_G0273467", "Q555X3", "DDB_G0274803", "Q556Z3", "DDB_G0273209", "Q86K94", "DDB_G0277135", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q559Q3", "DDB_G0272298", "Q54J84", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54VR1", "DDB_G0288221", "Q8T2J5", "DDB_G0271968", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q55CT5", "DDB_G0270992", "Q54DS8", "DDB_G0292052", "Q54EA5", "DDB_G0291694", "Q55CR0", "DDB_G0269942", "P34139", "DDB_G0283757", "species_29438", "Q553R1", "DDB_G0275331", "Q54DS8", "DDB_G0292052", "Q55CT5", "DDB_G0270992", "Q54EA5", "DDB_G0291694", "Q559Q3", "DDB_G0272298", "Q54J84", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54VR1", "DDB_G0288221", "Q8T2J5", "DDB_G0271968", "Q54T59", "DDB_G0281985", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q54Z72", "DDB_G0277797", "Q54C46", "DDB_G0293248", "Q553R1", "DDB_G0275331", "Q55CR0", "DDB_G0269942", "Q54UU1", "DDB_G0280827", "Q54TK7", "DDB_G0281693", "Q54RV6", "DDB_G0282887", "Q54CU7", "DDB_G0292690", "Q54YG5", "DDB_G0278643", "Q557G3", "DDB_G0273467", "Q555X3", "DDB_G0274803", "Q556Z3", "DDB_G0273209", "Q86K94", "DDB_G0277135", "DDB_G0281985", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "DDB_G0273059" ] }, "reaction_10611738": { "compartment": "compartment_6791047", "id": "reaction_10611738", "reactome": "R-DDI-5694423", "name": "NSF and SNAPs bind cis-SNARE complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611694", "species_10611734", "species_10611703" ], "products": [ "species_10611736" ], "modifiers": [], "additional_components": [ "Q75JI3", "DDB_G0276153", "Q55CR0", "DDB_G0269942", "Q54IJ1", "DDB_G0288719", "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q55FD0", "DDB_G0268452", "Q54NP6", "DDB_G0285111", "Q54NP6", "DDB_G0285111", "Q55CR0", "DDB_G0269942", "Q54IJ1", "DDB_G0288719", "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q55FD0", "DDB_G0268452", "Q75JI3", "DDB_G0276153" ] }, "reaction_10618329": { "compartment": "compartment_6791047", "id": "reaction_10618329", "reactome": "R-DDI-6814833", "name": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618324" ], "products": [ "species_10611571", "species_10618322" ], "modifiers": [ [ "species_10618324", "catalyst" ] ], "additional_components": [ "Q54RT5", "DDB_G0283055", "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "P34139", "DDB_G0283757", "species_29420", "DDB_G0283055", "Q54RT5", "DDB_G0283055", "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736" ] }, "reaction_10611629": { "compartment": "compartment_13959", "id": "reaction_10611629", "reactome": "R-DDI-5694409", "name": "Nucleotide exchange on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10611622" ], "products": [ "species_29420", "species_10611626" ], "modifiers": [ [ "species_10611622", "catalyst" ] ], "additional_components": [ "P34139", "DDB_G0283757", "species_29420", "Q54UU1", "DDB_G0280827", "Q54TK7", "DDB_G0281693", "Q54RV6", "DDB_G0282887", "Q54CU7", "DDB_G0292690", "Q54YG5", "DDB_G0278643", "Q557G3", "DDB_G0273467", "Q555X3", "DDB_G0274803", "Q556Z3", "DDB_G0273209", "Q86K94", "DDB_G0277135", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q559Q3", "DDB_G0272298", "Q54J84", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54VR1", "DDB_G0288221", "Q8T2J5", "DDB_G0271968", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q55CT5", "DDB_G0270992", "Q54DS8", "DDB_G0292052", "Q54EA5", "DDB_G0291694", "Q55CR0", "DDB_G0269942", "Q54UU1", "DDB_G0280827", "Q54TK7", "DDB_G0281693", "Q54RV6", "DDB_G0282887", "Q54CU7", "DDB_G0292690", "Q54YG5", "DDB_G0278643", "Q557G3", "DDB_G0273467", "Q555X3", "DDB_G0274803", "Q556Z3", "DDB_G0273209", "Q86K94", "DDB_G0277135", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q559Q3", "DDB_G0272298", "Q54J84", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54VR1", "DDB_G0288221", "Q8T2J5", "DDB_G0271968", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q55CT5", "DDB_G0270992", "Q54DS8", "DDB_G0292052", "Q54EA5", "DDB_G0291694", "Q55CR0", "DDB_G0269942", "P34139", "DDB_G0283757", "species_29438", "P34139", "DDB_G0283757", "species_29420", "Q54UU1", "DDB_G0280827", "Q54TK7", "DDB_G0281693", "Q54RV6", "DDB_G0282887", "Q54CU7", "DDB_G0292690", "Q54YG5", "DDB_G0278643", "Q557G3", "DDB_G0273467", "Q555X3", "DDB_G0274803", "Q556Z3", "DDB_G0273209", "Q86K94", "DDB_G0277135", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q559Q3", "DDB_G0272298", "Q54J84", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54VR1", "DDB_G0288221", "Q8T2J5", "DDB_G0271968", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q55CT5", "DDB_G0270992", "Q54DS8", "DDB_G0292052", "Q54EA5", "DDB_G0291694", "Q55CR0", "DDB_G0269942" ] }, "reaction_10611741": { "compartment": "compartment_6791047", "id": "reaction_10611741", "reactome": "R-DDI-5694425", "name": "NSF ATPase activity dissociates cis-SNARE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10611736" ], "products": [ "species_10611694", "species_10611710", "species_10611724", "species_10611708", "species_29372", "species_10611703", "species_10611732", "species_10611715" ], "modifiers": [ [ "species_10611736", "catalyst" ] ], "additional_components": [ "Q54NP6", "DDB_G0285111", "Q55CR0", "DDB_G0269942", "Q54IJ1", "DDB_G0288719", "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q55FD0", "DDB_G0268452", "Q75JI3", "DDB_G0276153", "Q75JI3", "DDB_G0276153", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "DDB_G0282433", "Q54NP6", "DDB_G0285111", "Q55CR0", "DDB_G0269942", "DDB_G0288719", "Q54NP6", "DDB_G0285111", "Q55CR0", "DDB_G0269942", "Q54IJ1", "DDB_G0288719", "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q55FD0", "DDB_G0268452", "Q75JI3", "DDB_G0276153" ] }, "reaction_10611839": { "compartment": "compartment_12045", "id": "reaction_10611839", "reactome": "R-DDI-5694522", "name": "Inner coat assembly and cargo binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587919", "species_10588090", "species_10587992" ], "products": [ "species_10587994" ], "modifiers": [], "additional_components": [ "Q559R0", "DDB_G0272296", "species_29438", "Q54T59", "DDB_G0281985", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q54Z72", "DDB_G0277797", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54J84", "DDB_G0288221", "Q559Q3", "DDB_G0272298", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54J84", "DDB_G0288221", "Q559Q3", "DDB_G0272298", "Q559R0", "DDB_G0272296", "species_29438" ] }, "reaction_10617088": { "compartment": "compartment_432051", "id": "reaction_10617088", "reactome": "R-DDI-6809003", "name": "ERGIC-to-Golgi vesicles bind dynein:dynactin ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617084", "species_10605683" ], "products": [ "species_10617086" ], "modifiers": [], "additional_components": [ "Q54BK5", "DDB_G0293712", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "Q558I0", "DDB_G0272905", "P34141", "DDB_G0291233", "P34140", "DDB_G0277867", "Q54EW9", "DDB_G0291293", "P34143", "DDB_G0271736", "Q552K3", "DDB_G0275969", "Q54NU2", "DDB_G0284985", "species_29438", "Q553R1", "DDB_G0275331", "Q54HL0", "DDB_G0289371", "Q23924", "DDB_G0284735", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "Q54HD4", "DDB_G0289523", "Q55FR9", "DDB_G0267982", "Q55FU2", "DDB_G0267950", "Q54YD8", "DDB_G0278285", "Q769F6", "DDB_G0277923", "Q769F9", "DDB_G0288053", "Q54BN0", "DDB_G0293540", "Q769F7", "DDB_G0278969", "Q86JE5", "DDB_G0272124", "Q54SJ2", "DDB_G0282433", "Q54V78", "DDB_G0280565", "P05095", "DDB_G0268632", "Q550R2", "DDB_G0276893", "P54703", "DDB_G0280849", "Q86A88", "DDB_G0274815", "Q54CI8", "DDB_G0292904", "P34036", "DDB_G0276355", "Q54VD6", "DDB_G0280435", "Q54ZI7", "DDB_G0277561", "Q54N50", "DDB_G0285503", "P13021", "DDB_G0267374", "P13022", "DDB_G0272104", "Q54JY2", "DDB_G0287739", "Q54FM4", "DDB_G0290757", "Q54VS0", "DDB_G0280175", "Q54XU5", "DDB_G0278579", "Q54I79", "DDB_G0288937", "species_29438", "species_29420", "P54703", "DDB_G0280849", "Q86A88", "DDB_G0274815", "Q54CI8", "DDB_G0292904", "P34036", "DDB_G0276355", "Q54VD6", "DDB_G0280435", "Q54ZI7", "DDB_G0277561", "Q54N50", "DDB_G0285503", "P13021", "DDB_G0267374", "P13022", "DDB_G0272104", "Q54JY2", "DDB_G0287739", "Q54FM4", "DDB_G0290757", "Q54VS0", "DDB_G0280175", "Q54XU5", "DDB_G0278579", "Q54I79", "DDB_G0288937", "species_29438", "species_29420", "Q54BK5", "DDB_G0293712", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "Q558I0", "DDB_G0272905", "P34141", "DDB_G0291233", "P34140", "DDB_G0277867", "Q54EW9", "DDB_G0291293", "P34143", "DDB_G0271736", "Q552K3", "DDB_G0275969", "Q54NU2", "DDB_G0284985", "Q553R1", "DDB_G0275331", "Q54HL0", "DDB_G0289371", "Q23924", "DDB_G0284735", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "Q54HD4", "DDB_G0289523", "Q55FR9", "DDB_G0267982", "Q55FU2", "DDB_G0267950", "Q54YD8", "DDB_G0278285", "Q769F6", "DDB_G0277923", "Q769F9", "DDB_G0288053", "Q54BN0", "DDB_G0293540", "Q769F7", "DDB_G0278969", "Q86JE5", "DDB_G0272124", "Q54SJ2", "DDB_G0282433", "Q54V78", "DDB_G0280565", "P05095", "DDB_G0268632", "Q550R2", "DDB_G0276893" ] }, "reaction_10617281": { "compartment": "compartment_20699", "id": "reaction_10617281", "reactome": "R-DDI-6809015", "name": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617276", "species_113592" ], "products": [ "species_29372", "species_10617262", "species_10617256", "species_10617258", "species_10617237", "species_10617143", "species_10617254" ], "modifiers": [ [ "species_10617276", "catalyst" ] ], "additional_components": [ "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712", "Q54QH2", "DDB_G0283831", "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q55FD0", "DDB_G0268452", "Q75JI3", "DDB_G0276153", "DDB_G0268452", "DDB_G0282433", "DDB_G0277565", "DDB_G0282433", "DDB_G0293712", "DDB_G0283831", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712", "Q54QH2", "DDB_G0283831", "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q55FD0", "DDB_G0268452", "Q75JI3", "DDB_G0276153" ] }, "reaction_10616792": { "compartment": "compartment_6791047", "id": "reaction_10616792", "reactome": "R-DDI-6807868", "name": "GBF1 stimulates ARF nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10616785" ], "products": [ "species_29370", "species_10616789" ], "modifiers": [ [ "species_10616785", "catalyst" ] ], "additional_components": [ "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q553R1", "DDB_G0275331", "species_29420", "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q553R1", "DDB_G0275331", "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q553R1", "DDB_G0275331", "species_29420" ] }, "reaction_10616779": { "compartment": "compartment_6791047", "id": "reaction_10616779", "reactome": "R-DDI-6807864", "name": "RAB1:GTP recruits GBF1 to the ERGIC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616775", "species_10616771", "species_10611792" ], "products": [ "species_10616777" ], "modifiers": [], "additional_components": [ "Q553R1", "DDB_G0275331", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q553R1", "DDB_G0275331" ] }, "reaction_10617272": { "compartment": "compartment_20699", "id": "reaction_10617272", "reactome": "R-DDI-6809011", "name": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617268", "species_10617249" ], "products": [ "species_10617270" ], "modifiers": [], "additional_components": [ "Q54QH2", "DDB_G0283831", "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q55FD0", "DDB_G0268452", "Q54C46", "DDB_G0293248", "Q54YV5", "DDB_G0278061", "Q54LC8", "DDB_G0286705", "Q54C87", "DDB_G0293106", "Q54ZB3", "DDB_G0277691", "Q54UC2", "DDB_G0281163", "Q55BB8", "DDB_G0271388", "Q54HE0", "DDB_G0289535", "Q54CT0", "DDB_G0292784", "Q54TT4", "DDB_G0281511", "Q769F9", "DDB_G0288053", "Q54BN0", "DDB_G0293540", "Q769F6", "DDB_G0277923", "Q769F7", "DDB_G0278969", "Q54BK5", "DDB_G0293712", "Q55FU2", "DDB_G0267950", "Q54YD8", "DDB_G0278285", "Q55FR9", "DDB_G0267982", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "Q54HD4", "DDB_G0289523", "Q54HL0", "DDB_G0289371", "Q23924", "DDB_G0284735", "Q553R1", "DDB_G0275331", "species_29438", "Q552K3", "DDB_G0275969", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "Q558I0", "DDB_G0272905", "P34141", "DDB_G0291233", "P34140", "DDB_G0277867", "Q54EW9", "DDB_G0291293", "P34143", "DDB_G0271736", "Q86JE5", "DDB_G0272124", "Q54SJ2", "DDB_G0282433", "Q54V78", "DDB_G0280565", "P05095", "DDB_G0268632", "Q550R2", "DDB_G0276893", "Q54C46", "DDB_G0293248", "Q54YV5", "DDB_G0278061", "Q54LC8", "DDB_G0286705", "Q54C87", "DDB_G0293106", "Q54ZB3", "DDB_G0277691", "Q54UC2", "DDB_G0281163", "Q55BB8", "DDB_G0271388", "Q54HE0", "DDB_G0289535", "Q54CT0", "DDB_G0292784", "Q54TT4", "DDB_G0281511", "Q769F9", "DDB_G0288053", "Q54BN0", "DDB_G0293540", "Q769F6", "DDB_G0277923", "Q769F7", "DDB_G0278969", "Q54BK5", "DDB_G0293712", "Q55FU2", "DDB_G0267950", "Q54YD8", "DDB_G0278285", "Q55FR9", "DDB_G0267982", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "Q54HD4", "DDB_G0289523", "Q54HL0", "DDB_G0289371", "Q23924", "DDB_G0284735", "Q553R1", "DDB_G0275331", "species_29438", "Q552K3", "DDB_G0275969", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "Q558I0", "DDB_G0272905", "P34141", "DDB_G0291233", "P34140", "DDB_G0277867", "Q54EW9", "DDB_G0291293", "P34143", "DDB_G0271736", "Q86JE5", "DDB_G0272124", "Q54SJ2", "DDB_G0282433", "Q54V78", "DDB_G0280565", "P05095", "DDB_G0268632", "Q550R2", "DDB_G0276893", "Q54QH2", "DDB_G0283831", "Q54ZH1", "DDB_G0277565", "Q55FD0", "DDB_G0268452" ] }, "reaction_10617278": { "compartment": "compartment_20699", "id": "reaction_10617278", "reactome": "R-DDI-6809014", "name": "cis-Golgi cis-SNARE binds NSF and SNAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611694", "species_10617274", "species_10611703" ], "products": [ "species_10617276" ], "modifiers": [], "additional_components": [ "Q75JI3", "DDB_G0276153", "Q54BK5", "DDB_G0293712", "Q54QH2", "DDB_G0283831", "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q55FD0", "DDB_G0268452", "Q54NP6", "DDB_G0285111", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712", "Q54QH2", "DDB_G0283831", "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q55FD0", "DDB_G0268452", "Q75JI3", "DDB_G0276153" ] }, "reaction_10616847": { "compartment": "compartment_6791047", "id": "reaction_10616847", "reactome": "R-DDI-6807872", "name": "Active ARF recruits coatomer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616843", "species_10616789" ], "products": [ "species_10616845" ], "modifiers": [], "additional_components": [ "Q55EZ6", "DDB_G0268702", "Q23924", "DDB_G0284735", "Q54HL0", "DDB_G0289371", "Q54CA7", "DDB_G0293086", "Q54HD4", "DDB_G0289523", "Q54YD8", "DDB_G0278285", "Q55FU2", "DDB_G0267950", "Q55FR9", "DDB_G0267982", "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q553R1", "DDB_G0275331", "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q553R1", "DDB_G0275331", "Q55EZ6", "DDB_G0268702", "Q23924", "DDB_G0284735", "Q54HL0", "DDB_G0289371", "Q54CA7", "DDB_G0293086", "Q54HD4", "DDB_G0289523", "Q54YD8", "DDB_G0278285", "Q55FU2", "DDB_G0267950", "Q55FR9", "DDB_G0267982" ] }, "reaction_10611650": { "compartment": "compartment_12045", "id": "reaction_10611650", "reactome": "R-DDI-5694413", "name": "SEC4C,D bind GOSR2 and STX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587933", "species_10587931", "species_10587937" ], "products": [ "species_10587939" ], "modifiers": [], "additional_components": [ "DDB_G0277797", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "DDB_G0281985", "Q54T59", "DDB_G0281985", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q54Z72", "DDB_G0277797" ] }, "reaction_10611654": { "compartment": "compartment_12045", "id": "reaction_10611654", "reactome": "R-DDI-5694415", "name": "SEC24A,B:SEC23A bind SEC22B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10588084", "species_10587872", "species_10587937" ], "products": [ "species_10611652" ], "modifiers": [], "additional_components": [ "DDB_G0281255", "DDB_G0269942", "DDB_G0281985", "Q55CR0", "DDB_G0269942", "Q54U61", "DDB_G0281255", "Q54T59", "DDB_G0281985" ] }, "reaction_10611743": { "compartment": "compartment_12045", "id": "reaction_10611743", "reactome": "R-DDI-5694428", "name": "LMAN family proteins bind glycosylated cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587988", "species_10587954" ], "products": [ "species_10587990" ], "modifiers": [], "additional_components": [ "Q54VR1", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54J84", "DDB_G0288221", "Q559Q3", "DDB_G0272298", "Q8T2J5", "DDB_G0271968", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54J84", "DDB_G0288221", "Q559Q3", "DDB_G0272298" ] }, "reaction_10626054": { "compartment": "compartment_876", "id": "reaction_10626054", "reactome": "R-DDI-9606884", "name": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_113592", "species_10626042" ], "products": [ "species_29370", "species_10626052" ], "modifiers": [], "additional_components": [ "Q54CE1", "DDB_G0293166", "Q54U56", "DDB_G0293166", "Q54U56", "DDB_G0293166", "Q54CE1", "DDB_G0293166", "species_179838" ] }, "reaction_10597136": { "compartment": "compartment_876", "id": "reaction_10597136", "reactome": "R-DDI-1168636", "name": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10585874" ], "products": [ "species_29420", "species_10585144" ], "modifiers": [ [ "species_10597133", "catalyst" ] ], "additional_components": [ "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29420", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "species_6797635", "Q8IS15", "DDB_G0277915", "Q8IS16", "DDB_G0276963", "B0M0P8", "DDB_G0276371", "Q54C94", "DDB_G0293006", "Q8IS20", "DDB_G0282381", "Q8IS21", "DDB_G0269222", "Q54FF3", "DDB_G0290901", "Q54H95", "DDB_G0289613", "Q8SSQ0", "DDB_G0274605", "Q8SSW7", "DDB_G0271868", "Q54PQ4", "DDB_G0284329", "Q54XL4", "DDB_G0289613", "Q8ST25", "DDB_G0272032", "Q55FD8", "DDB_G0268578", "Q55GH9", "DDB_G0267666", "Q8IS11", "DDB_G0290267", "Q8IS14", "DDB_G0277913" ] }, "reaction_10627377": { "compartment": "compartment_70101", "id": "reaction_10627377", "reactome": "R-DDI-9690461", "name": "FKBP1A binds tacrolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584268", "species_9678991" ], "products": [ "species_10627375" ], "modifiers": [], "additional_components": [ "DDB_G0280877", "Q54UR2", "DDB_G0280877" ] }, "reaction_10622977": { "compartment": "compartment_7660", "id": "reaction_10622977", "reactome": "R-DDI-8937022", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10622972" ], "products": [ "species_77502", "species_10622974" ], "modifiers": [ [ "species_10622972", "catalyst" ] ], "additional_components": [ "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863", "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "O15819", "DDB_G0267402", "Q54F38", "DDB_G0291185", "Q76NW2", "DDB_G0276863", "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863" ] }, "reaction_10622950": { "compartment": "compartment_7660", "id": "reaction_10622950", "reactome": "R-DDI-8936608", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10622945" ], "products": [ "species_77502", "species_10622947" ], "modifiers": [ [ "species_10622945", "catalyst" ] ], "additional_components": [ "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863", "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "O15819", "DDB_G0267402", "Q54F38", "DDB_G0291185", "Q76NW2", "DDB_G0276863", "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863" ] }, "reaction_10622986": { "compartment": "compartment_7660", "id": "reaction_10622986", "reactome": "R-DDI-8937113", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10622981" ], "products": [ "species_77502", "species_10622983" ], "modifiers": [ [ "species_10622981", "catalyst" ] ], "additional_components": [ "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863", "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "O15819", "DDB_G0267402", "Q54F38", "DDB_G0291185", "Q76NW2", "DDB_G0276863", "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863" ] }, "reaction_10622941": { "compartment": "compartment_7660", "id": "reaction_10622941", "reactome": "R-DDI-8936584", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10622927" ], "products": [ "species_77502", "species_10622938" ], "modifiers": [ [ "species_10622927", "catalyst" ] ], "additional_components": [ "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863", "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "O15819", "DDB_G0267402", "Q54F38", "DDB_G0291185", "Q76NW2", "DDB_G0276863", "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863" ] }, "reaction_10583367": { "compartment": "compartment_17906", "id": "reaction_10583367", "reactome": "R-DDI-114284", "name": "Release of Cytochrome c from mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583365" ], "products": [ "species_10583363" ], "modifiers": [], "additional_components": [ "DDB_G0275537", "DDB_G0275537" ] }, "reaction_10582546": { "compartment": "compartment_7660", "id": "reaction_10582546", "reactome": "R-DDI-109636", "name": "Recognition and Binding of Core Promoter Elements by TFIID", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580910", "species_109627" ], "products": [ "species_10581548" ], "modifiers": [], "additional_components": [ "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617" ] }, "reaction_10582548": { "compartment": "compartment_7660", "id": "reaction_10582548", "reactome": "R-DDI-109637", "name": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580844", "species_10581548", "species_10580839" ], "products": [ "species_10581550" ], "modifiers": [], "additional_components": [ "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54FD6", "DDB_G0290929" ] }, "reaction_10581556": { "compartment": "compartment_7660", "id": "reaction_10581556", "reactome": "R-DDI-75095", "name": "Binding of TFIIE to the growing preinitiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580922", "species_10581552" ], "products": [ "species_10581554" ], "modifiers": [], "additional_components": [ "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54FD6", "DDB_G0290929", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54FD6", "DDB_G0290929", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307" ] }, "reaction_10582550": { "compartment": "compartment_7660", "id": "reaction_10582550", "reactome": "R-DDI-109638", "name": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581550", "species_10578889" ], "products": [ "species_10581552" ], "modifiers": [], "additional_components": [ "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54FD6", "DDB_G0290929", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54FD6", "DDB_G0290929" ] }, "reaction_10582552": { "compartment": "compartment_7660", "id": "reaction_10582552", "reactome": "R-DDI-109639", "name": "Formation of the closed pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580699", "species_10581554" ], "products": [ "species_10581638" ], "modifiers": [], "additional_components": [ "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54FD6", "DDB_G0290929", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54FD6", "DDB_G0290929", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307" ] }, "reaction_10582721": { "compartment": "compartment_7660", "id": "reaction_10582721", "reactome": "R-DDI-110227", "name": "Cleavage of dihydrouracil by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582718" ], "products": [ "species_30140", "species_10582704" ], "modifiers": [ [ "species_10582718", "catalyst" ] ], "additional_components": [ "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247" ] }, "reaction_10582691": { "compartment": "compartment_7660", "id": "reaction_10582691", "reactome": "R-DDI-110215", "name": "Cleavage of uracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582684" ], "products": [ "species_29554", "species_10582688" ], "modifiers": [ [ "species_10582684", "catalyst" ] ], "additional_components": [ "P53766", "DDB_G0277877", "P53766", "DDB_G0277877", "P53766", "DDB_G0277877" ] }, "reaction_10582707": { "compartment": "compartment_7660", "id": "reaction_10582707", "reactome": "R-DDI-110224", "name": "Cleavage of thymine glycol by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582702" ], "products": [ "species_110223", "species_10582704" ], "modifiers": [ [ "species_10582702", "catalyst" ] ], "additional_components": [ "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247" ] }, "reaction_10582728": { "compartment": "compartment_7660", "id": "reaction_10582728", "reactome": "R-DDI-110229", "name": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582725" ], "products": [ "species_5637659", "species_10582704" ], "modifiers": [ [ "species_10582725", "catalyst" ] ], "additional_components": [ "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247" ] }, "reaction_10582747": { "compartment": "compartment_7660", "id": "reaction_10582747", "reactome": "R-DDI-110244", "name": "Excision of FapyG by OGG1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582744" ], "products": [ "species_5636006", "species_10582739" ], "modifiers": [ [ "species_10582744", "catalyst" ] ], "additional_components": [ "Q54CZ3", "DDB_G0292618", "Q54CZ3", "DDB_G0292618", "Q54CZ3", "DDB_G0292618" ] }, "reaction_10582698": { "compartment": "compartment_7660", "id": "reaction_10582698", "reactome": "R-DDI-110217", "name": "Cleavage of 5-hydroxyluracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582695" ], "products": [ "species_110216", "species_10582688" ], "modifiers": [ [ "species_10582695", "catalyst" ] ], "additional_components": [ "P53766", "DDB_G0277877", "P53766", "DDB_G0277877", "P53766", "DDB_G0277877" ] }, "reaction_10582714": { "compartment": "compartment_7660", "id": "reaction_10582714", "reactome": "R-DDI-110226", "name": "Cleavage of cytosine glycol by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582711" ], "products": [ "species_10582704", "species_110225" ], "modifiers": [ [ "species_10582711", "catalyst" ] ], "additional_components": [ "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247" ] }, "reaction_10604323": { "compartment": "compartment_17963", "id": "reaction_10604323", "reactome": "R-DDI-4837364", "name": "Secretion of SOD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604321" ], "products": [ "species_10602381" ], "modifiers": [], "additional_components": [ "species_29426", "species_437295", "Q55GQ5", "DDB_G0267420", "species_29426", "Q55GQ5", "DDB_G0267420", "species_437295" ] }, "reaction_10602402": { "compartment": "compartment_70101", "id": "reaction_10602402", "reactome": "R-DDI-3299691", "name": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_1222424" ], "products": [ "species_29368", "species_29408" ], "modifiers": [ [ "species_10602399", "catalyst" ] ], "additional_components": [ "species_29426", "species_437295", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993", "Q55GQ5", "DDB_G0267420" ] }, "reaction_10602373": { "compartment": "compartment_5460", "id": "reaction_10602373", "reactome": "R-DDI-3299680", "name": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_3299683" ], "products": [ "species_113533", "species_1614617" ], "modifiers": [ [ "species_10602370", "catalyst" ] ], "additional_components": [ "species_266099", "Q55BJ9", "DDB_G0271106" ] }, "reaction_10602664": { "compartment": "compartment_5460", "id": "reaction_10602664", "reactome": "R-DDI-3323079", "name": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_1655882", "species_113600" ], "products": [ "species_113563", "species_1655887" ], "modifiers": [ [ "species_10602661", "catalyst" ] ], "additional_components": [ "Q8T137", "DDB_G0272754", "species_113596" ] }, "reaction_10602668": { "compartment": "compartment_70616", "id": "reaction_10602668", "reactome": "R-DDI-3341294", "name": "Superoxide reduces cytochrome c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3341308", "species_10584033" ], "products": [ "species_10584031", "species_189461" ], "modifiers": [], "additional_components": [ "CHEBI:38574", "Q869N1", "DDB_G0275537", "CHEBI:38573", "Q869N1", "DDB_G0275537" ] }, "reaction_10602384": { "compartment": "compartment_984", "id": "reaction_10602384", "reactome": "R-DDI-3299682", "name": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_3299686" ], "products": [ "species_351629", "species_352327" ], "modifiers": [ [ "species_10602381", "catalyst" ] ], "additional_components": [ "species_29426", "Q55GQ5", "DDB_G0267420", "species_437295" ] }, "reaction_10602421": { "compartment": "compartment_70101", "id": "reaction_10602421", "reactome": "R-DDI-3299753", "name": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602414" ], "products": [ "species_10602399", "species_10602418" ], "modifiers": [ [ "species_10602414", "catalyst" ] ], "additional_components": [ "CHEBI:49552", "species_29426", "Q54F73", "DDB_G0291031", "Q55GQ5", "DDB_G0267420", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993", "species_29426", "species_437295", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993", "Q55GQ5", "DDB_G0267420", "species_29426", "CHEBI:49552", "Q54F73", "DDB_G0291031", "CHEBI:49552", "species_29426", "Q54F73", "DDB_G0291031", "Q55GQ5", "DDB_G0267420", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993" ] }, "reaction_10603063": { "compartment": "compartment_70101", "id": "reaction_10603063", "reactome": "R-DDI-3697860", "name": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602412", "species_10603059" ], "products": [ "species_10603061" ], "modifiers": [], "additional_components": [ "species_29426", "Q55GQ5", "DDB_G0267420", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993", "CHEBI:49552", "species_29426", "Q54F73", "DDB_G0291031", "CHEBI:49552", "species_29426", "Q54F73", "DDB_G0291031", "Q55GQ5", "DDB_G0267420", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993" ] }, "reaction_10616759": { "compartment": "compartment_12045", "id": "reaction_10616759", "reactome": "R-DDI-6807557", "name": "NOX4, NOX5 reduce O2 to O2.-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29364" ], "products": [ "species_70106", "species_1222424", "species_29366" ], "modifiers": [ [ "species_10616756", "catalyst" ] ], "additional_components": [ "Q867X6", "DDB_G0267460", "Q54F44", "DDB_G0291117", "Q86GL4", "DDB_G0287101", "Q9XYS3", "DDB_G0289653" ] }, "reaction_10623544": { "compartment": "compartment_70101", "id": "reaction_10623544", "reactome": "R-DDI-8951723", "name": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603061" ], "products": [ "species_10602414" ], "modifiers": [], "additional_components": [ "CHEBI:49552", "species_29426", "Q54F73", "DDB_G0291031", "Q55GQ5", "DDB_G0267420", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993", "CHEBI:49552", "species_29426", "Q54F73", "DDB_G0291031", "Q55GQ5", "DDB_G0267420", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993" ] }, "reaction_10603066": { "compartment": "compartment_5460", "id": "reaction_10603066", "reactome": "R-DDI-3697894", "name": "PRDX5 reduces peroxynitrite to nitrite using TXN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602633", "species_3697881" ], "products": [ "species_10602636", "species_3697842", "species_113521" ], "modifiers": [ [ "species_10602650", "catalyst" ] ], "additional_components": [ "DDB_G0284939", "DDB_G0284939", "DDB_G0285741" ] }, "reaction_10603197": { "compartment": "compartment_17927", "id": "reaction_10603197", "reactome": "R-DDI-3777112", "name": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3341308", "species_163953" ], "products": [ "species_189481", "species_189461" ], "modifiers": [ [ "species_10603194", "catalyst" ] ], "additional_components": [ "species_437295", "species_29426", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993", "Q55GQ5", "DDB_G0267420" ] }, "reaction_10581788": { "compartment": "compartment_17951", "id": "reaction_10581788", "reactome": "R-DDI-76031", "name": "2 H2O2 => O2 + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113575" ], "products": [ "species_113535", "species_141343" ], "modifiers": [ [ "species_10581785", "catalyst" ] ], "additional_components": [ "species_917877", "species_29364", "O77229", "DDB_G0274595" ] }, "reaction_10602655": { "compartment": "compartment_5460", "id": "reaction_10602655", "reactome": "R-DDI-3322995", "name": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602633", "species_1614617" ], "products": [ "species_10602636", "species_113521" ], "modifiers": [ [ "species_10602652", "catalyst" ] ], "additional_components": [ "DDB_G0284939", "DDB_G0284939", "Q54W09", "DDB_G0279973", "Q54N76", "DDB_G0285741" ] }, "reaction_10602686": { "compartment": "compartment_70101", "id": "reaction_10602686", "reactome": "R-DDI-3343700", "name": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_29408" ], "products": [ "species_29356", "species_111745" ], "modifiers": [ [ "species_10602683", "catalyst" ] ], "additional_components": [ "Q556P3", "DDB_G0273153", "Q55FF3", "DDB_G0268138", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q54VI4", "DDB_G0280317", "Q556G3", "DDB_G0272632", "Q54SE2", "DDB_G0282517" ] }, "reaction_10600900": { "compartment": "compartment_70101", "id": "reaction_10600900", "reactome": "R-DDI-2393939", "name": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1131972" ], "products": [ "species_73578", "species_76577" ], "modifiers": [ [ "species_10600897", "catalyst" ] ], "additional_components": [ "species_29926", "Q54S89", "DDB_G0282603" ] }, "reaction_10577424": { "compartment": "compartment_7660", "id": "reaction_10577424", "reactome": "R-DDI-69053", "name": "RFC binding displaces Pol Alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577420", "species_10577245" ], "products": [ "species_10577422" ], "modifiers": [], "additional_components": [ "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MD4", "DDB_G0286027", "Q54MH9", "DDB_G0285961", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MD4", "DDB_G0286027", "Q54MH9", "DDB_G0285961" ] }, "reaction_10577462": { "compartment": "compartment_7660", "id": "reaction_10577462", "reactome": "R-DDI-69074", "name": "Formation of Processive Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577437", "species_10577458" ], "products": [ "species_10577460" ], "modifiers": [], "additional_components": [ "Q54K47", "DDB_G0287607", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731" ] }, "reaction_10577435": { "compartment": "compartment_7660", "id": "reaction_10577435", "reactome": "R-DDI-69063", "name": "Loading of PCNA - Sliding Clamp Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577422", "species_29358", "species_10577431" ], "products": [ "species_113582", "species_10577433" ], "modifiers": [], "additional_components": [ "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MD4", "DDB_G0286027", "Q54MH9", "DDB_G0285961", "Q54K47", "DDB_G0287607", "Q54K47", "DDB_G0287607", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MD4", "DDB_G0286027", "Q54MH9", "DDB_G0285961" ] }, "reaction_10577439": { "compartment": "compartment_7660", "id": "reaction_10577439", "reactome": "R-DDI-69068", "name": "RFC dissociates after sliding clamp formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577433" ], "products": [ "species_10577420", "species_10577437" ], "modifiers": [], "additional_components": [ "Q54K47", "DDB_G0287607", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MD4", "DDB_G0286027", "Q54MH9", "DDB_G0285961", "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MD4", "DDB_G0286027", "Q54MH9", "DDB_G0285961", "Q54K47", "DDB_G0287607", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731" ] }, "reaction_10618449": { "compartment": "compartment_20699", "id": "reaction_10618449", "reactome": "R-DDI-8847887", "name": "RAB33B:GTP binds RIC1:RGP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618445", "species_10618439" ], "products": [ "species_10618447" ], "modifiers": [], "additional_components": [ "Q54WR7", "DDB_G0279477", "Q76NU4", "DDB_G0277397", "O76173", "DDB_G0269174", "species_29438", "O76173", "DDB_G0269174", "species_29438", "Q54WR7", "DDB_G0279477", "Q76NU4", "DDB_G0277397" ] }, "reaction_10618433": { "compartment": "compartment_20699", "id": "reaction_10618433", "reactome": "R-DDI-8847883", "name": "CYTH proteins stimulate ARF1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618424" ], "products": [ "species_10618430" ], "modifiers": [ [ "species_10618424", "catalyst" ] ], "additional_components": [ "species_29438", "O00909", "DDB_G0289173", "Q54Y34", "DDB_G0292332", "Q1ZXA5", "DDB_G0292332", "Q54YV7", "DDB_G0278057", "Q54HK2", "DDB_G0289435", "Q55AR1", "DDB_G0271792", "Q54JJ3", "DDB_G0288015", "Q54SH9", "DDB_G0282457", "Q54V41", "DDB_G0280633", "Q54V47", "DDB_G0280621", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "O00909", "DDB_G0289173", "Q54Y34", "DDB_G0292332", "Q1ZXA5", "DDB_G0292332", "Q54YV7", "DDB_G0278057", "Q54HK2", "DDB_G0289435", "Q55AR1", "DDB_G0271792", "Q54JJ3", "DDB_G0288015", "Q54SH9", "DDB_G0282457", "Q54V41", "DDB_G0280633", "Q54V47", "DDB_G0280621", "Q54VB0", "DDB_G0280479", "species_29420", "species_29438", "O00909", "DDB_G0289173", "Q54Y34", "DDB_G0292332", "Q1ZXA5", "DDB_G0292332", "Q54YV7", "DDB_G0278057", "Q54HK2", "DDB_G0289435", "Q55AR1", "DDB_G0271792", "Q54JJ3", "DDB_G0288015", "Q54SH9", "DDB_G0282457", "Q54V41", "DDB_G0280633", "Q54V47", "DDB_G0280621", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771" ] }, "reaction_10618612": { "compartment": "compartment_20699", "id": "reaction_10618612", "reactome": "R-DDI-8849748", "name": "The COG complex binds RABs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617130", "species_10618608" ], "products": [ "species_10618610" ], "modifiers": [], "additional_components": [ "Q54LC8", "DDB_G0286705", "Q54C87", "DDB_G0293106", "Q54ZB3", "DDB_G0277691", "Q54UC2", "DDB_G0281163", "Q55BB8", "DDB_G0271388", "Q54HE0", "DDB_G0289535", "Q54CT0", "DDB_G0292784", "Q54TT4", "DDB_G0281511", "Q54G48", "DDB_G0290407", "Q54FL2", "DDB_G0290783", "Q54S62", "DDB_G0294577", "Q54P07", "DDB_G0285051", "Q55EF0", "DDB_G0269262", "Q54S63", "DDB_G0282651", "Q86JC8", "DDB_G0275955", "Q55EG6", "DDB_G0268910", "Q8T193", "DDB_G0294577", "Q86JP5", "DDB_G0271980", "Q1ZXG2", "DDB_G0294577", "Q54E92", "DDB_G0291738", "Q1ZXN9", "DDB_G0294577", "species_29438", "Q559X6", "DDB_G0272138", "Q55ET3", "DDB_G0268760", "P36409", "DDB_G0292268", "Q55FK2", "DDB_G0268068", "Q54G48", "DDB_G0290407", "Q54FL2", "DDB_G0290783", "Q54S62", "DDB_G0294577", "Q54P07", "DDB_G0285051", "Q55EF0", "DDB_G0269262", "Q54S63", "DDB_G0282651", "Q86JC8", "DDB_G0275955", "Q55EG6", "DDB_G0268910", "Q8T193", "DDB_G0294577", "Q86JP5", "DDB_G0271980", "Q1ZXG2", "DDB_G0294577", "Q54E92", "DDB_G0291738", "Q1ZXN9", "DDB_G0294577", "species_29438", "Q559X6", "DDB_G0272138", "Q55ET3", "DDB_G0268760", "P36409", "DDB_G0292268", "Q55FK2", "DDB_G0268068", "Q54LC8", "DDB_G0286705", "Q54C87", "DDB_G0293106", "Q54ZB3", "DDB_G0277691", "Q54UC2", "DDB_G0281163", "Q55BB8", "DDB_G0271388", "Q54HE0", "DDB_G0289535", "Q54CT0", "DDB_G0292784", "Q54TT4", "DDB_G0281511" ] }, "reaction_10618426": { "compartment": "compartment_20699", "id": "reaction_10618426", "reactome": "R-DDI-8847880", "name": "CYTH proteins bind ARF1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598835", "species_10618402" ], "products": [ "species_10618424" ], "modifiers": [], "additional_components": [ "species_29438", "O00909", "DDB_G0289173", "Q54Y34", "DDB_G0292332", "Q1ZXA5", "DDB_G0292332", "Q54YV7", "DDB_G0278057", "Q54HK2", "DDB_G0289435", "Q55AR1", "DDB_G0271792", "Q54JJ3", "DDB_G0288015", "Q54SH9", "DDB_G0282457", "Q54V41", "DDB_G0280633", "Q54V47", "DDB_G0280621", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "species_29438", "O00909", "DDB_G0289173", "Q54Y34", "DDB_G0292332", "Q1ZXA5", "DDB_G0292332", "Q54YV7", "DDB_G0278057", "Q54HK2", "DDB_G0289435", "Q55AR1", "DDB_G0271792", "Q54JJ3", "DDB_G0288015", "Q54SH9", "DDB_G0282457", "Q54V41", "DDB_G0280633", "Q54V47", "DDB_G0280621", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771" ] }, "reaction_10618379": { "compartment": "compartment_20699", "id": "reaction_10618379", "reactome": "R-DDI-8847637", "name": "NSF and SNAPs bind the cis-SNARE at the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611694", "species_10611703", "species_10618375" ], "products": [ "species_10618377" ], "modifiers": [], "additional_components": [ "Q75JI3", "DDB_G0276153", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712", "Q54ZH1", "DDB_G0277565", "Q54SJ2", "DDB_G0282433", "Q54QH2", "DDB_G0283831", "Q54BK5", "DDB_G0293712", "Q54ZH1", "DDB_G0277565", "Q54SJ2", "DDB_G0282433", "Q54QH2", "DDB_G0283831", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153" ] }, "reaction_10617758": { "compartment": "compartment_20699", "id": "reaction_10617758", "reactome": "R-DDI-6811433", "name": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617754", "species_10617130" ], "products": [ "species_10617756" ], "modifiers": [], "additional_components": [ "Q553C3", "DDB_G0275765", "Q54CK6", "DDB_G0292974", "Q54R67", "DDB_G0283363", "Q54QH2", "DDB_G0283831", "Q551H5", "DDB_G0276575", "Q54PW2", "DDB_G0284185", "Q54I20", "DDB_G0289063", "Q54PQ5", "DDB_G0289063", "Q54ZH1", "DDB_G0277565", "Q54SJ2", "DDB_G0282433", "Q54GE3", "DDB_G0290213", "Q55FD0", "DDB_G0268452", "Q55GN5", "DDB_G0267590", "Q54LC8", "DDB_G0286705", "Q54C87", "DDB_G0293106", "Q54ZB3", "DDB_G0277691", "Q54UC2", "DDB_G0281163", "Q55BB8", "DDB_G0271388", "Q54HE0", "DDB_G0289535", "Q54CT0", "DDB_G0292784", "Q54TT4", "DDB_G0281511", "Q54LC8", "DDB_G0286705", "Q54C87", "DDB_G0293106", "Q54ZB3", "DDB_G0277691", "Q54UC2", "DDB_G0281163", "Q55BB8", "DDB_G0271388", "Q54HE0", "DDB_G0289535", "Q54CT0", "DDB_G0292784", "Q54TT4", "DDB_G0281511", "Q553C3", "DDB_G0275765", "Q54CK6", "DDB_G0292974", "Q54R67", "DDB_G0283363", "Q54QH2", "DDB_G0283831", "Q551H5", "DDB_G0276575", "Q54PW2", "DDB_G0284185", "Q54I20", "DDB_G0289063", "Q54PQ5", "DDB_G0289063", "Q54ZH1", "DDB_G0277565", "Q54SJ2", "DDB_G0282433", "Q54GE3", "DDB_G0290213", "Q55FD0", "DDB_G0268452", "Q55GN5", "DDB_G0267590" ] }, "reaction_10618382": { "compartment": "compartment_20699", "id": "reaction_10618382", "reactome": "R-DDI-8847638", "name": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618377", "species_113592" ], "products": [ "species_10611694", "species_10617256", "species_29370", "species_10617258", "species_10611703", "species_10617143", "species_10617254" ], "modifiers": [ [ "species_10618377", "catalyst" ] ], "additional_components": [ "Q54BK5", "DDB_G0293712", "Q54ZH1", "DDB_G0277565", "Q54SJ2", "DDB_G0282433", "Q54QH2", "DDB_G0283831", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153", "Q75JI3", "DDB_G0276153", "DDB_G0282433", "DDB_G0277565", "Q54NP6", "DDB_G0285111", "DDB_G0293712", "DDB_G0283831", "Q54BK5", "DDB_G0293712", "Q54ZH1", "DDB_G0277565", "Q54SJ2", "DDB_G0282433", "Q54QH2", "DDB_G0283831", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153" ] }, "reaction_10606649": { "compartment": "compartment_70101", "id": "reaction_10606649", "reactome": "R-DDI-5665854", "name": "ADRM1:26S proteaseome binds UCHL5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606638", "species_10606645" ], "products": [ "species_10606647" ], "modifiers": [], "additional_components": [ "DDB_G0285527", "Q556N5", "DDB_G0272624", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408", "Q556N5", "DDB_G0272624", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408", "Q54N38", "DDB_G0285527" ] }, "reaction_10611049": { "compartment": "compartment_70101", "id": "reaction_10611049", "reactome": "R-DDI-5690319", "name": "UCHL1, UCHL3 cleave ubiquitin adducts", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10611044" ], "products": [ "species_1131871", "species_10611046" ], "modifiers": [ [ "species_10611044", "catalyst" ] ], "additional_components": [ "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14797", "DDB_G0276765", "Q54T48", "DDB_G0282007", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54T48", "DDB_G0282007", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14797", "DDB_G0276765", "Q54T48", "DDB_G0282007" ] }, "reaction_10606686": { "compartment": "compartment_70101", "id": "reaction_10606686", "reactome": "R-DDI-5665871", "name": "ADRM1 binds 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577240", "species_10606643" ], "products": [ "species_10606645" ], "modifiers": [], "additional_components": [ "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408", "DDB_G0272624", "Q556N5", "DDB_G0272624", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10590556": { "compartment": "compartment_70101", "id": "reaction_10590556", "reactome": "R-DDI-391266", "name": "Association of CCT/TriC with sphingosine kinase 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590508", "species_10590552" ], "products": [ "species_10590554" ], "modifiers": [], "additional_components": [ "DDB_G0284545", "Q55BM4", "DDB_G0269190", "Q54TD3", "DDB_G0281849", "Q54ER7", "DDB_G0291225", "Q76NU3", "DDB_G0277493", "Q54ES9", "DDB_G0291358", "Q54CL2", "DDB_G0292872", "species_29370", "Q54TH8", "DDB_G0281741", "Q552J0", "DDB_G0276233", "Q55BM4", "DDB_G0269190", "Q54TD3", "DDB_G0281849", "Q54ER7", "DDB_G0291225", "Q76NU3", "DDB_G0277493", "Q54ES9", "DDB_G0291358", "Q54CL2", "DDB_G0292872", "species_29370", "Q54TH8", "DDB_G0281741", "Q552J0", "DDB_G0276233", "Q6B516", "DDB_G0284545" ] }, "reaction_10617873": { "compartment": "compartment_70101", "id": "reaction_10617873", "reactome": "R-DDI-6814119", "name": "TRiC/CCT binds unfolded G-protein beta subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590552", "species_10589812" ], "products": [ "species_10617871" ], "modifiers": [], "additional_components": [ "Q55BM4", "DDB_G0269190", "Q54TD3", "DDB_G0281849", "Q54ER7", "DDB_G0291225", "Q76NU3", "DDB_G0277493", "Q54ES9", "DDB_G0291358", "Q54CL2", "DDB_G0292872", "species_29370", "Q54TH8", "DDB_G0281741", "Q552J0", "DDB_G0276233", "DDB_G0277143", "P36408", "DDB_G0277143", "Q55BM4", "DDB_G0269190", "Q54TD3", "DDB_G0281849", "Q54ER7", "DDB_G0291225", "Q76NU3", "DDB_G0277493", "Q54ES9", "DDB_G0291358", "Q54CL2", "DDB_G0292872", "species_29370", "Q54TH8", "DDB_G0281741", "Q552J0", "DDB_G0276233" ] }, "reaction_10617879": { "compartment": "compartment_70101", "id": "reaction_10617879", "reactome": "R-DDI-6814120", "name": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617877" ], "products": [ "species_10617871", "species_29372" ], "modifiers": [], "additional_components": [ "Q55BM4", "DDB_G0269190", "Q54TD3", "DDB_G0281849", "Q54ER7", "DDB_G0291225", "Q76NU3", "DDB_G0277493", "Q54ES9", "DDB_G0291358", "species_113592", "Q54CL2", "DDB_G0292872", "Q54TH8", "DDB_G0281741", "Q552J0", "DDB_G0276233", "P36408", "DDB_G0277143", "P36408", "DDB_G0277143", "Q55BM4", "DDB_G0269190", "Q54TD3", "DDB_G0281849", "Q54ER7", "DDB_G0291225", "Q76NU3", "DDB_G0277493", "Q54ES9", "DDB_G0291358", "Q54CL2", "DDB_G0292872", "species_29370", "Q54TH8", "DDB_G0281741", "Q552J0", "DDB_G0276233" ] }, "reaction_10617881": { "compartment": "compartment_70101", "id": "reaction_10617881", "reactome": "R-DDI-6814124", "name": "ATP binds G-protein beta associated TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617871", "species_113592" ], "products": [ "species_29370", "species_10617877" ], "modifiers": [], "additional_components": [ "P36408", "DDB_G0277143", "Q55BM4", "DDB_G0269190", "Q54TD3", "DDB_G0281849", "Q54ER7", "DDB_G0291225", "Q76NU3", "DDB_G0277493", "Q54ES9", "DDB_G0291358", "Q54CL2", "DDB_G0292872", "species_29370", "Q54TH8", "DDB_G0281741", "Q552J0", "DDB_G0276233", "Q55BM4", "DDB_G0269190", "Q54TD3", "DDB_G0281849", "Q54ER7", "DDB_G0291225", "Q76NU3", "DDB_G0277493", "Q54ES9", "DDB_G0291358", "species_113592", "Q54CL2", "DDB_G0292872", "Q54TH8", "DDB_G0281741", "Q552J0", "DDB_G0276233", "P36408", "DDB_G0277143" ] }, "reaction_10611316": { "compartment": "compartment_984", "id": "reaction_10611316", "reactome": "R-DDI-5693346", "name": "CECRI deaminates Ade-Rib to Ino", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_83908" ], "products": [ "species_2022135", "species_83921" ], "modifiers": [ [ "species_10611313", "catalyst" ] ], "additional_components": [ "species_29426", "Q553U5", "DDB_G0275179" ] }, "reaction_10608345": { "compartment": "compartment_3828046", "id": "reaction_10608345", "reactome": "R-DDI-5684864", "name": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5685882", "species_10608214" ], "products": [ "species_10608286", "species_10608238", "species_10608262" ], "modifiers": [ [ "species_10608342", "catalyst" ] ], "additional_components": [ "B0G0Z4", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q55EI1", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q54SX7", "DDB_G0292508", "Q54WE0", "DDB_G0279713", "Q54WE4", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q54SX7", "DDB_G0292508", "Q54WE0", "DDB_G0279713", "Q54WE4", "DDB_G0292508", "B0G0Z4", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q55EI1", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q54SX7", "DDB_G0292508", "Q54WE0", "DDB_G0279713", "Q54WE4", "DDB_G0292508", "B0G0Z4", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q55EI1", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "B0G0Z4", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q55EI1", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q54SX7", "DDB_G0292508", "Q54WE0", "DDB_G0279713", "Q54WE4", "DDB_G0292508", "P04989", "DDB_G0279799", "Q23894", "DDB_G0283867", "Q54RQ2", "DDB_G0282991", "Q54TR1", "DDB_G0281605", "Q54UH2", "DDB_G0282991", "Q54UH3", "DDB_G0282991", "Q86KD4", "DDB_G0282991", "O76856", "DDB_G0279411" ] }, "reaction_10612937": { "compartment": "compartment_3828046", "id": "reaction_10612937", "reactome": "R-DDI-6791016", "name": "SFTPB binds itself", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608238" ], "products": [ "species_10608347" ], "modifiers": [], "additional_components": [ "Q54LG3", "DDB_G0292508", "Q54SX7", "DDB_G0292508", "Q54WE0", "DDB_G0279713", "Q54WE4", "DDB_G0292508", "B0G0Z4", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q55EI1", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q54SX7", "DDB_G0292508", "Q54WE0", "DDB_G0279713", "Q54WE4", "DDB_G0292508", "B0G0Z4", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q55EI1", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508" ] }, "reaction_10626233": { "compartment": "compartment_12045", "id": "reaction_10626233", "reactome": "R-DDI-9624789", "name": "pro-SFTPB translocates from ER membrane to multivesicle body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626231" ], "products": [ "species_10608214" ], "modifiers": [], "additional_components": [ "Q54C60", "DDB_G0293010", "Q55EI1", "DDB_G0292508", "B0G0Z4", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54SX7", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q54WE4", "DDB_G0292508", "Q54WE0", "DDB_G0279713", "B0G0Z4", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q55EI1", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q54SX7", "DDB_G0292508", "Q54WE0", "DDB_G0279713", "Q54WE4", "DDB_G0292508" ] }, "reaction_10608074": { "compartment": "compartment_2133233", "id": "reaction_10608074", "reactome": "R-DDI-5683714", "name": "ABCA3 transports PC, PG from ER membrane to lamellar body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5684863" ], "products": [ "species_29372", "species_29370", "species_5684869" ], "modifiers": [ [ "species_10608071", "catalyst" ] ], "additional_components": [ "species_426925", "species_1483256", "species_426925", "species_1483256", "Q8T6J1", "DDB_G0291245", "Q8T6J2", "DDB_G0274119", "Q8T6J5", "DDB_G0267438", "Q54BT5", "DDB_G0293436", "Q555Z5", "DDB_G0274121", "Q55BC0", "DDB_G0271138", "Q8T5Z7", "DDB_G0291994" ] }, "reaction_10592403": { "compartment": "compartment_1462052", "id": "reaction_10592403", "reactome": "R-DDI-437085", "name": "ZnT5 transports zinc into secretory granules in pancreatic beta cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216785" ], "modifiers": [ [ "species_10592400", "catalyst" ] ], "additional_components": [ "Q54F34", "DDB_G0291141", "Q55E98", "DDB_G0291141" ] }, "reaction_10592411": { "compartment": "compartment_20699", "id": "reaction_10592411", "reactome": "R-DDI-437136", "name": "SLC30A8 transports Zn2+ from cytosol to secretory granule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216785" ], "modifiers": [ [ "species_10592408", "catalyst" ] ], "additional_components": [ "DDB_G0283629" ] }, "reaction_10589007": { "compartment": "compartment_876", "id": "reaction_10589007", "reactome": "R-DDI-265177", "name": "Exocyst complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10588988", "species_10588973", "species_10589003", "species_10588968", "species_10588998", "species_10588983", "species_10588978", "species_10588993" ], "products": [ "species_10589005" ], "modifiers": [], "additional_components": [ "DDB_G0279991", "DDB_G0280081", "DDB_G0272991", "DDB_G0284833", "DDB_G0293520", "DDB_G0293936", "DDB_G0287881", "DDB_G0285067", "Q54NV1", "DDB_G0285067", "B0G163", "DDB_G0287881", "Q54B27", "DDB_G0293936", "Q54BP6", "DDB_G0293520", "Q54P76", "DDB_G0284833", "Q558Z9", "DDB_G0272991", "Q54VX5", "DDB_G0280081", "Q54VZ8", "DDB_G0279991" ] }, "reaction_10599268": { "compartment": "compartment_70101", "id": "reaction_10599268", "reactome": "R-DDI-1799332", "name": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599262", "species_10599264" ], "products": [ "species_10599266" ], "modifiers": [], "additional_components": [ "Q556L1", "DDB_G0272590", "Q54EP7", "DDB_G0291412", "Q55GL2", "DDB_G0267622", "Q554G7", "DDB_G0275211", "Q75K18", "DDB_G0275455", "Q1ZXE8", "DDB_G0285821", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q556L1", "DDB_G0272590", "Q54EP7", "DDB_G0291412", "Q55GL2", "DDB_G0267622", "Q554G7", "DDB_G0275211", "Q75K18", "DDB_G0275455", "Q1ZXE8", "DDB_G0285821" ] }, "reaction_10583761": { "compartment": "compartment_70101", "id": "reaction_10583761", "reactome": "R-DDI-156913", "name": "Regeneration of eEF1A:GTP by eEF1B activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10583756", "species_10583752" ], "products": [ "species_10583758", "species_10583738" ], "modifiers": [ [ "species_10583752", "catalyst" ] ], "additional_components": [ "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "species_29420", "Q9GRF8", "DDB_G0284035", "B0G141", "DDB_G0282979", "Q9GRF8", "DDB_G0284035", "B0G141", "DDB_G0282979", "species_29420", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "species_29438", "Q9GRF8", "DDB_G0284035", "B0G141", "DDB_G0282979" ] }, "reaction_10583771": { "compartment": "compartment_70101", "id": "reaction_10583771", "reactome": "R-DDI-156930", "name": "GTP-binding activates eEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10583767" ], "products": [ "species_10583769" ], "modifiers": [], "additional_components": [ "DDB_G0288373", "P15112", "DDB_G0288373", "species_29438" ] }, "reaction_10583754": { "compartment": "compartment_70101", "id": "reaction_10583754", "reactome": "R-DDI-156910", "name": "Formation of eEF1B complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583743", "species_10583750", "species_10583745" ], "products": [ "species_10583752" ], "modifiers": [], "additional_components": [ "DDB_G0284035", "DDB_G0282979", "DDB_G0284035", "Q9GRF8", "DDB_G0284035", "B0G141", "DDB_G0282979" ] }, "reaction_10583720": { "compartment": "compartment_70101", "id": "reaction_10583720", "reactome": "R-DDI-156823", "name": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583711", "species_10583716" ], "products": [ "species_10583718" ], "modifiers": [], "additional_components": [ "Q75K16", "DDB_G0275459", "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "Q54BM2", "DDB_G0293558", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "DDB_G0275881", "Q553M7", "DDB_G0275881", "Q75K16", "DDB_G0275459", "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "Q54BM2", "DDB_G0293558", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395" ] }, "reaction_10583724": { "compartment": "compartment_70101", "id": "reaction_10583724", "reactome": "R-DDI-156826", "name": "Dissociation of L13a from the 60s ribosomal subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580367" ], "products": [ "species_10583722", "species_10580149" ], "modifiers": [], "additional_components": [ "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "DDB_G0275881" ] }, "reaction_10580065": { "compartment": "compartment_70101", "id": "reaction_10580065", "reactome": "R-DDI-72631", "name": "Formation of the cap-binding eIF4F complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580029", "species_10580024", "species_10580019" ], "products": [ "species_10580031" ], "modifiers": [], "additional_components": [ "DDB_G0275395", "DDB_G0268574", "P90529", "DDB_G0269146", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395" ] }, "reaction_10583713": { "compartment": "compartment_70101", "id": "reaction_10583713", "reactome": "R-DDI-156808", "name": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583709", "species_10583704", "species_10580008", "species_10579985" ], "products": [ "species_10583711", "species_10579985" ], "modifiers": [], "additional_components": [ "DDB_G0293558", "Q75K16", "DDB_G0275459", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "DDB_G0278205", "Q75K16", "DDB_G0275459", "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "Q54BM2", "DDB_G0293558", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "DDB_G0278205" ] }, "reaction_10583773": { "compartment": "compartment_70101", "id": "reaction_10583773", "reactome": "R-DDI-157849", "name": "Formation of translation initiation complexes containing mRNA that does not circularize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580008", "species_10580071", "species_10579985" ], "products": [ "species_10580040", "species_10579985" ], "modifiers": [], "additional_components": [ "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "Q75K16", "DDB_G0275459", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "DDB_G0278205", "Q75K16", "DDB_G0275459", "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "DDB_G0278205" ] }, "reaction_10580074": { "compartment": "compartment_70101", "id": "reaction_10580074", "reactome": "R-DDI-72647", "name": "Cap-bound mRNA is activated by helicases ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10580038", "species_10580036", "species_10580069", "species_10580019" ], "products": [ "species_29372", "species_29370", "species_10580071", "species_10580019", "species_72595" ], "modifiers": [ [ "species_10580019", "catalyst" ] ], "additional_components": [ "DDB_G0275459", "DDB_G0275459", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "P90529", "DDB_G0269146", "Q75K16", "DDB_G0275459", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "P90529", "DDB_G0269146", "P90529", "DDB_G0269146" ] }, "reaction_10580063": { "compartment": "compartment_70101", "id": "reaction_10580063", "reactome": "R-DDI-72622", "name": "Release of eIF4E from the inactive eIF4E:4E-BP complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580061" ], "products": [ "species_10580059", "species_10580024" ], "modifiers": [], "additional_components": [ "Q55FE0", "DDB_G0268574", "Q54DU8", "DDB_G0291990", "DDB_G0291990", "DDB_G0268574" ] }, "reaction_10580054": { "compartment": "compartment_70101", "id": "reaction_10580054", "reactome": "R-DDI-72621", "name": "Ribosomal scanning ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10580040" ], "products": [ "species_29372", "species_29370", "species_10580040" ], "modifiers": [ [ "species_72617", "catalyst" ], [ "species_113592", "catalyst" ] ], "additional_components": [ "Q75K16", "DDB_G0275459", "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "Q75K16", "DDB_G0275459", "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395" ] }, "reaction_10580396": { "compartment": "compartment_70101", "id": "reaction_10580396", "reactome": "R-DDI-72697", "name": "Start codon recognition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580045", "species_10580040", "species_72617", "species_10580002", "species_10579985" ], "products": [ "species_10580045", "species_10580040", "species_72617", "species_10580002", "species_10579985" ], "modifiers": [ [ "species_72617", "catalyst" ] ], "additional_components": [ "DDB_G0286753", "Q75K16", "DDB_G0275459", "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "DDB_G0278205", "DDB_G0286753", "Q75K16", "DDB_G0275459", "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "DDB_G0278205" ] }, "reaction_10580394": { "compartment": "compartment_70101", "id": "reaction_10580394", "reactome": "R-DDI-72691", "name": "Formation of the 43S pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580390", "species_10580006" ], "products": [ "species_10580008" ], "modifiers": [], "additional_components": [ "Q54YJ6", "DDB_G0278205", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254" ] }, "reaction_10580076": { "compartment": "compartment_70101", "id": "reaction_10580076", "reactome": "R-DDI-72663", "name": "De novo formation of eIF2:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10580002" ], "products": [ "species_10580004" ], "modifiers": [], "additional_components": [ "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438" ] }, "reaction_10580078": { "compartment": "compartment_70101", "id": "reaction_10580078", "reactome": "R-DDI-72669", "name": "Met-tRNAi binds to eIF2:GTP to form the ternary complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_72393", "species_10580004" ], "products": [ "species_10580006" ], "modifiers": [ [ "species_29438", "catalyst" ] ], "additional_components": [ "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438" ] }, "reaction_10580384": { "compartment": "compartment_70101", "id": "reaction_10580384", "reactome": "R-DDI-72671", "name": "eIF5B:GTP is hydrolyzed and released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580378" ], "products": [ "species_10580382", "species_10580380", "species_29372" ], "modifiers": [], "additional_components": [ "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54XP6", "DDB_G0278815", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54XP6", "DDB_G0278815", "species_29420" ] }, "reaction_10580051": { "compartment": "compartment_70101", "id": "reaction_10580051", "reactome": "R-DDI-72619", "name": "eIF2:GTP is hydrolyzed, eIFs are released ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580045", "species_10580040", "species_72617" ], "products": [ "species_10580047", "species_10579980", "species_10580029", "species_10580045", "species_29372", "species_10580024", "species_10580038", "species_10580036", "species_10580019", "species_10579985", "species_10580049" ], "modifiers": [ [ "species_10580045", "catalyst" ] ], "additional_components": [ "DDB_G0286753", "Q75K16", "DDB_G0275459", "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "DDB_G0275395", "DDB_G0286753", "DDB_G0268574", "DDB_G0275459", "DDB_G0275459", "P90529", "DDB_G0269146", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29420", "DDB_G0286753" ] }, "reaction_10580386": { "compartment": "compartment_70101", "id": "reaction_10580386", "reactome": "R-DDI-72672", "name": "The 60S subunit joins the translation initiation complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580047", "species_10580367", "species_10580376" ], "products": [ "species_10580378" ], "modifiers": [], "additional_components": [ "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54XP6", "DDB_G0278815", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54XP6", "DDB_G0278815", "species_29438" ] }, "reaction_10580388": { "compartment": "compartment_70101", "id": "reaction_10580388", "reactome": "R-DDI-72673", "name": "Release of 40S and 60S subunits from the 80S ribosome ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10579985", "species_10580369" ], "products": [ "species_10580367", "species_10579913", "species_10579985" ], "modifiers": [], "additional_components": [ "DDB_G0278205", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "DDB_G0278205" ] }, "reaction_10580392": { "compartment": "compartment_70101", "id": "reaction_10580392", "reactome": "R-DDI-72676", "name": "eIF3 and eIF1A bind to the 40S subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10579980", "species_10579913", "species_10579985" ], "products": [ "species_10580390" ], "modifiers": [], "additional_components": [ "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "DDB_G0278205", "Q54YJ6", "DDB_G0278205", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254" ] }, "reaction_10593013": { "compartment": "compartment_5460", "id": "reaction_10593013", "reactome": "R-DDI-449937", "name": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159450", "species_113521" ], "products": [ "species_113548" ], "modifiers": [ [ "species_10593010", "catalyst" ], [ "species_109496", "catalyst" ] ], "additional_components": [ "Q54PV8", "DDB_G0284265" ] }, "reaction_10578737": { "compartment": "compartment_70101", "id": "reaction_10578737", "reactome": "R-DDI-71732", "name": "pyrophosphate + H2O => 2 orthophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111294", "species_29356" ], "products": [ "species_29372" ], "modifiers": [ [ "species_10578734", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54PV8", "DDB_G0284265" ] }, "reaction_10601713": { "compartment": "compartment_7660", "id": "reaction_10601713", "reactome": "R-DDI-2993763", "name": "SENP1,2,5 proteolytically process SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601709" ], "products": [ "species_10601711" ], "modifiers": [ [ "species_10601673", "catalyst" ] ], "additional_components": [ "DDB_G0282161", "DDB_G0282161", "Q54DG4", "DDB_G0292290" ] }, "reaction_10601685": { "compartment": "compartment_7660", "id": "reaction_10601685", "reactome": "R-DDI-2990842", "name": "SENP1,2,5 proteolytically process SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601681" ], "products": [ "species_10601683" ], "modifiers": [ [ "species_10601673", "catalyst" ] ], "additional_components": [ "DDB_G0282161", "DDB_G0282161", "Q54DG4", "DDB_G0292290" ] }, "reaction_10601676": { "compartment": "compartment_7660", "id": "reaction_10601676", "reactome": "R-DDI-2990840", "name": "SENP1,2,5 proteolytically process SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601662" ], "products": [ "species_10594213" ], "modifiers": [ [ "species_10601673", "catalyst" ] ], "additional_components": [ "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q54DG4", "DDB_G0292290" ] }, "reaction_10601746": { "compartment": "compartment_7660", "id": "reaction_10601746", "reactome": "R-DDI-2993780", "name": "Transfer of SUMO1 from E1 to UBE2I (UBC9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601725", "species_10601653" ], "products": [ "species_10601743", "species_10601638" ], "modifiers": [ [ "species_10601638", "catalyst" ] ], "additional_components": [ "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54L40", "DDB_G0286919", "Q54WI4", "DDB_G0279641", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54L40", "DDB_G0286919", "Q54WI4", "DDB_G0279641", "Q54L40", "DDB_G0286919", "Q54WI4", "DDB_G0279641" ] }, "reaction_10601656": { "compartment": "compartment_7660", "id": "reaction_10601656", "reactome": "R-DDI-2990833", "name": "Conjugation of SUMO1 to UBA2:SAE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10601638", "species_10594213" ], "products": [ "species_164121", "species_10601653", "species_113541" ], "modifiers": [ [ "species_10601638", "catalyst" ] ], "additional_components": [ "Q54L40", "DDB_G0286919", "Q54WI4", "DDB_G0279641", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54L40", "DDB_G0286919", "Q54WI4", "DDB_G0279641", "Q54L40", "DDB_G0286919", "Q54WI4", "DDB_G0279641" ] }, "reaction_10603971": { "compartment": "compartment_7660", "id": "reaction_10603971", "reactome": "R-DDI-4570496", "name": "SUMOylation of Histone H4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10581418" ], "products": [ "species_10601725", "species_10603969" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0276863", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q76NW2", "DDB_G0276863", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10604098": { "compartment": "compartment_7660", "id": "reaction_10604098", "reactome": "R-DDI-4616015", "name": "SUMOylation of HDAC2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10603140" ], "products": [ "species_10601725", "species_10604096" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0268024", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q55FN5", "DDB_G0268024", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10604058": { "compartment": "compartment_7660", "id": "reaction_10604058", "reactome": "R-DDI-4615889", "name": "SUMOylation of HDAC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10597270" ], "products": [ "species_10601725", "species_10604056" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0268024", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q55FN5", "DDB_G0268024", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10603949": { "compartment": "compartment_7660", "id": "reaction_10603949", "reactome": "R-DDI-4570485", "name": "SUMOylation of Histone H4 with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581418", "species_10601799" ], "products": [ "species_10601725", "species_10603947" ], "modifiers": [ [ "species_10601799", "catalyst" ] ], "additional_components": [ "DDB_G0276863", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "DDB_G0276863", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161" ] }, "reaction_10603395": { "compartment": "compartment_7660", "id": "reaction_10603395", "reactome": "R-DDI-3900194", "name": "PIAS1 SUMOylates DDX5 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601786", "species_10579094" ], "products": [ "species_10601725", "species_10603392" ], "modifiers": [ [ "species_10594201", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q54SX2", "DDB_G0282161", "DDB_G0293168", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "DDB_G0293168", "Q54V57", "DDB_G0280603", "Q555X5", "DDB_G0274743" ] }, "reaction_10603490": { "compartment": "compartment_7660", "id": "reaction_10603490", "reactome": "R-DDI-4085992", "name": "SUMOylation of DAXX with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10602165" ], "products": [ "species_10601725", "species_10603488" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0279509", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54WP8", "DDB_G0279509", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10603511": { "compartment": "compartment_7660", "id": "reaction_10603511", "reactome": "R-DDI-4085994", "name": "TOPORS SUMOylates SIN3A with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10590689" ], "products": [ "species_10603503", "species_10601725" ], "modifiers": [ [ "species_10603508", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0281045", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54UJ3", "DDB_G0281045", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "DDB_G0281183" ] }, "reaction_10603528": { "compartment": "compartment_7660", "id": "reaction_10603528", "reactome": "R-DDI-4086083", "name": "SUMOylation of ING2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10603513" ], "products": [ "species_10601725", "species_10603526" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0284411", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54PN9", "DDB_G0284411", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10603563": { "compartment": "compartment_7660", "id": "reaction_10603563", "reactome": "R-DDI-4090284", "name": "SUMOylation of HIPK2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10603548" ], "products": [ "species_10601725", "species_10603561" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0283605", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q54QV3", "DDB_G0283605", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10603389": { "compartment": "compartment_7660", "id": "reaction_10603389", "reactome": "R-DDI-3900177", "name": "SUMOylation of DDX5 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10579094" ], "products": [ "species_10601725", "species_10603387" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0293168", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54CE0", "DDB_G0293168", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10603374": { "compartment": "compartment_7660", "id": "reaction_10603374", "reactome": "R-DDI-3900047", "name": "SUMOylation of DDX17 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10603354" ], "products": [ "species_10603372", "species_10601725" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54CB8", "DDB_G0293064", "Q54CE0", "DDB_G0293168", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q54CB8", "DDB_G0293064", "Q54CE0", "DDB_G0293168", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10604146": { "compartment": "compartment_7660", "id": "reaction_10604146", "reactome": "R-DDI-4641345", "name": "SUMOylation of TOP2B with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10604127" ], "products": [ "species_10601725", "species_10604144" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "P90520", "DDB_G0279737", "Q55BP5", "DDB_G0270418", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "P90520", "DDB_G0279737", "Q55BP5", "DDB_G0270418", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10604151": { "compartment": "compartment_7660", "id": "reaction_10604151", "reactome": "R-DDI-4641350", "name": "PIAS4 SUMOylates TOP2A with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601801", "species_10604103" ], "products": [ "species_10601725", "species_10604149" ], "modifiers": [ [ "species_10601810", "catalyst" ] ], "additional_components": [ "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161", "DDB_G0270418", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "DDB_G0270418", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10604118": { "compartment": "compartment_7660", "id": "reaction_10604118", "reactome": "R-DDI-4641342", "name": "SUMOylation of TOP2A with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10604103" ], "products": [ "species_10601725", "species_10604116" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0270418", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q55BP5", "DDB_G0270418", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10604075": { "compartment": "compartment_7660", "id": "reaction_10604075", "reactome": "R-DDI-4615910", "name": "SUMOylation of PCNA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10577429" ], "products": [ "species_10601725", "species_10604073" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0287607", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q54K47", "DDB_G0287607", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10604171": { "compartment": "compartment_7660", "id": "reaction_10604171", "reactome": "R-DDI-4641362", "name": "SUMOylation of TOP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10604156" ], "products": [ "species_10601725", "species_10604169" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0283205", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54RC3", "DDB_G0283205", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10604001": { "compartment": "compartment_7660", "id": "reaction_10604001", "reactome": "R-DDI-4570553", "name": "SUMOylation of MDC1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603996", "species_10601801" ], "products": [ "species_10603999", "species_10601725" ], "modifiers": [ [ "species_10601801", "catalyst" ] ], "additional_components": [ "DDB_G0272690", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161", "DDB_G0272690", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161" ] }, "reaction_10603872": { "compartment": "compartment_7660", "id": "reaction_10603872", "reactome": "R-DDI-4568848", "name": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10603852" ], "products": [ "species_10601725", "species_10603865" ], "modifiers": [ [ "species_10603869", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0278203", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54YJ7", "DDB_G0278203", "Q54V57", "DDB_G0280603", "Q555X5", "DDB_G0274743" ] }, "reaction_10603847": { "compartment": "compartment_7660", "id": "reaction_10603847", "reactome": "R-DDI-4551768", "name": "PIAS4 SUMOylates PARP1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600664", "species_10601801" ], "products": [ "species_10601725", "species_10603845" ], "modifiers": [ [ "species_10601810", "catalyst" ] ], "additional_components": [ "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54HY5", "DDB_G0289141", "Q8I7C6", "DDB_G0292820", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10601830": { "compartment": "compartment_7660", "id": "reaction_10601830", "reactome": "R-DDI-2997709", "name": "PIAS1,4 SUMOylates BRCA1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10601773" ], "products": [ "species_10601725", "species_10601828" ], "modifiers": [ [ "species_10601812", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0293300", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q54C05", "DDB_G0293300", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10603718": { "compartment": "compartment_7660", "id": "reaction_10603718", "reactome": "R-DDI-4551604", "name": "PIAS4 SUMOylates PARP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10600664" ], "products": [ "species_10601725", "species_10603716" ], "modifiers": [ [ "species_10601810", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54HY5", "DDB_G0289141", "Q8I7C6", "DDB_G0292820", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10601901": { "compartment": "compartment_7660", "id": "reaction_10601901", "reactome": "R-DDI-3000383", "name": "UBE2I, HDAC7 SUMOylate PML with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10601869" ], "products": [ "species_10601884", "species_10601725" ], "modifiers": [ [ "species_10601898", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0285989", "Q54MF7", "DDB_G0285989", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54VQ7", "DDB_G0280195", "Q54X15", "DDB_G0279267", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153" ] }, "reaction_10602028": { "compartment": "compartment_7660", "id": "reaction_10602028", "reactome": "R-DDI-3108212", "name": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10601093" ], "products": [ "species_10601725", "species_10601992" ], "modifiers": [ [ "species_10602025", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54QR0", "DDB_G0283681", "Q54E85", "DDB_G0291752", "Q552D9", "DDB_G0276101", "Q550H7", "DDB_G0276977", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54QR0", "DDB_G0283681", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q550H7", "DDB_G0276977", "Q54E85", "DDB_G0291752", "Q552D9", "DDB_G0276101", "Q54HN3", "DDB_G0289341", "Q54T56", "DDB_G0281991", "Q54FE3", "DDB_G0290919", "Q54PA3", "DDB_G0284679", "Q54X37", "DDB_G0279231", "Q54I56", "DDB_G0288993" ] }, "reaction_10603823": { "compartment": "compartment_7660", "id": "reaction_10603823", "reactome": "R-DDI-4551724", "name": "PIAS4 SUMOylates HERC2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10603779" ], "products": [ "species_10601725", "species_10603821" ], "modifiers": [ [ "species_10601810", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54Q89", "DDB_G0284033", "Q8MP76", "DDB_G0284033", "Q54R64", "DDB_G0284033", "Q54S74", "DDB_G0284033", "Q54SA3", "DDB_G0284033", "Q54WU2", "DDB_G0284033", "Q55CR5", "DDB_G0284033", "Q55DD2", "DDB_G0284033", "B0G136", "DDB_G0284033", "Q55GN7", "DDB_G0284033", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54Q89", "DDB_G0284033", "Q55CR5", "DDB_G0284033", "Q55DD2", "DDB_G0284033", "Q54R64", "DDB_G0284033", "Q54S74", "DDB_G0284033", "Q55GN7", "DDB_G0284033", "Q8MP76", "DDB_G0284033", "Q54SA3", "DDB_G0284033", "Q54WU2", "DDB_G0284033", "B0G136", "DDB_G0284033", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10603889": { "compartment": "compartment_7660", "id": "reaction_10603889", "reactome": "R-DDI-4568863", "name": "SUMOylation of RAD52 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10581772" ], "products": [ "species_10603887", "species_10601725" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0269406", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q55E38", "DDB_G0269406", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10604016": { "compartment": "compartment_7660", "id": "reaction_10604016", "reactome": "R-DDI-4570554", "name": "SUMOylation of MDC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10603996" ], "products": [ "species_10604014", "species_10601725" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0272690", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q86IG6", "DDB_G0272690", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10601815": { "compartment": "compartment_7660", "id": "reaction_10601815", "reactome": "R-DDI-2997616", "name": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601773", "species_10601801" ], "products": [ "species_10601804", "species_10601725" ], "modifiers": [ [ "species_10601812", "catalyst" ] ], "additional_components": [ "DDB_G0293300", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161", "DDB_G0293300", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10603991": { "compartment": "compartment_7660", "id": "reaction_10603991", "reactome": "R-DDI-4570528", "name": "SUMOylation of XPC with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10603976" ], "products": [ "species_10601725", "species_10603989" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0292296", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q1ZXA6", "DDB_G0292296", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10601914": { "compartment": "compartment_7660", "id": "reaction_10601914", "reactome": "R-DDI-3000433", "name": "SUMOylation of PML with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601869", "species_10601799" ], "products": [ "species_10601725", "species_10601911" ], "modifiers": [ [ "species_10601799", "catalyst" ] ], "additional_components": [ "DDB_G0285989", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "DDB_G0285989", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161" ] }, "reaction_10603903": { "compartment": "compartment_7660", "id": "reaction_10603903", "reactome": "R-DDI-4568914", "name": "SUMOylation of BLM with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601801", "species_10603894" ], "products": [ "species_10603900", "species_10601725" ], "modifiers": [ [ "species_10601801", "catalyst" ] ], "additional_components": [ "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161", "DDB_G0292130", "DDB_G0292130", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161" ] }, "reaction_10602897": { "compartment": "compartment_7660", "id": "reaction_10602897", "reactome": "R-DDI-3465545", "name": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602878", "species_10601801" ], "products": [ "species_10601725", "species_10602886" ], "modifiers": [ [ "species_10602894", "catalyst" ] ], "additional_components": [ "Q1ZXA2", "DDB_G0293468", "Q54MS4", "DDB_G0285693", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q1ZXA2", "DDB_G0293468", "Q54MS4", "DDB_G0285693", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10601851": { "compartment": "compartment_7660", "id": "reaction_10601851", "reactome": "R-DDI-2997723", "name": "PIAS4 SUMOylates TP53BP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10601835" ], "products": [ "species_10601725", "species_10601848" ], "modifiers": [ [ "species_10601810", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0286539", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54LN0", "DDB_G0286539", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10603474": { "compartment": "compartment_7660", "id": "reaction_10603474", "reactome": "R-DDI-4085350", "name": "SUMOylation of UBE2I with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10601725" ], "products": [ "species_10601725", "species_10603472" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10603446": { "compartment": "compartment_7660", "id": "reaction_10603446", "reactome": "R-DDI-3968362", "name": "SUMOylation of PIAS4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10601810" ], "products": [ "species_10601725", "species_10603444" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10603757": { "compartment": "compartment_7660", "id": "reaction_10603757", "reactome": "R-DDI-4551683", "name": "SUMOylation of TOPORS with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10603508" ], "products": [ "species_10601725", "species_10603755" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0281183", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54UA7", "DDB_G0281183", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10620075": { "compartment": "compartment_70101", "id": "reaction_10620075", "reactome": "R-DDI-8867370", "name": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589898", "species_113592", "species_29424" ], "products": [ "species_10620063", "species_29372", "species_29370" ], "modifiers": [ [ "species_10620072", "catalyst" ] ], "additional_components": [ "species_29438", "species_29420", "species_29438", "species_29420", "Q54TU1", "DDB_G0281541" ] }, "reaction_10623090": { "compartment": "compartment_70101", "id": "reaction_10623090", "reactome": "R-DDI-8938815", "name": "RNF152 polyubiquitinates RRAGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623077", "species_10623079" ], "products": [ "species_10623087", "species_10623070", "species_10587616" ], "modifiers": [ [ "species_10623079", "catalyst" ] ], "additional_components": [ "Q86K32", "DDB_G0277267", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54IK1", "DDB_G0288701", "species_29420", "Q86K32", "DDB_G0277267", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54L05", "DDB_G0286991", "species_29420", "Q54IK1", "DDB_G0288701", "DDB_G0286991", "DDB_G0277267", "Q54IK1", "DDB_G0288701", "species_29420", "Q86K32", "DDB_G0277267", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54L05", "DDB_G0286991" ] }, "reaction_10623282": { "compartment": "compartment_7660", "id": "reaction_10623282", "reactome": "R-DDI-8943007", "name": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623255", "species_10623270", "species_10623264", "species_10612435" ], "products": [ "species_10623272" ], "modifiers": [], "additional_components": [ "DDB_G0287171", "Q86K32", "DDB_G0277267", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54D06", "DDB_G0292596", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54KQ4", "DDB_G0287171" ] }, "reaction_10623906": { "compartment": "compartment_17947", "id": "reaction_10623906", "reactome": "R-DDI-8953917", "name": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623900", "species_10623902" ], "products": [ "species_10623904" ], "modifiers": [], "additional_components": [ "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54MD1", "DDB_G0286033", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54MD1", "DDB_G0286033" ] }, "reaction_10623280": { "compartment": "compartment_7660", "id": "reaction_10623280", "reactome": "R-DDI-8943003", "name": "SHPRH polyubiquitinates monoubiquitinated PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623272", "species_10623270" ], "products": [ "species_10623277", "species_10623255", "species_10623264", "species_10608545" ], "modifiers": [ [ "species_10623272", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54KQ4", "DDB_G0287171", "Q86K32", "DDB_G0277267", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54D06", "DDB_G0292596", "Q54K47", "DDB_G0287607", "DDB_G0287171", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54KQ4", "DDB_G0287171" ] }, "reaction_10623062": { "compartment": "compartment_70101", "id": "reaction_10623062", "reactome": "R-DDI-8938770", "name": "RNF144A binds PRKDC and Ubiquitin:UBE2L3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623047", "species_10623056", "species_10623058" ], "products": [ "species_10623060" ], "modifiers": [], "additional_components": [ "DDB_G0281167", "Q54ZG5", "DDB_G0277577", "Q54QC7", "DDB_G0283939", "Q54TE1", "DDB_G0281833", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54TE1", "DDB_G0281833", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54ZG5", "DDB_G0277577", "Q54QC7", "DDB_G0283939", "Q54UC0", "DDB_G0281167" ] }, "reaction_10623092": { "compartment": "compartment_70101", "id": "reaction_10623092", "reactome": "R-DDI-8938829", "name": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623070", "species_10623077", "species_10623072" ], "products": [ "species_10623079" ], "modifiers": [], "additional_components": [ "DDB_G0286991", "Q86K32", "DDB_G0277267", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54IK1", "DDB_G0288701", "species_29420", "Q54IK1", "DDB_G0288701", "species_29420", "Q86K32", "DDB_G0277267", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54L05", "DDB_G0286991" ] }, "reaction_10623306": { "compartment": "compartment_7660", "id": "reaction_10623306", "reactome": "R-DDI-8943041", "name": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623270", "species_10623264", "species_10612435", "species_10623299" ], "products": [ "species_10623301" ], "modifiers": [], "additional_components": [ "Q86K32", "DDB_G0277267", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54D06", "DDB_G0292596", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "Q54T24", "DDB_G0281949", "B0G105", "DDB_G0282115", "Q54SZ4", "DDB_G0282115", "Q54T24", "DDB_G0281949", "B0G105", "DDB_G0282115", "Q54SZ4", "DDB_G0282115", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596" ] }, "reaction_10623304": { "compartment": "compartment_7660", "id": "reaction_10623304", "reactome": "R-DDI-8943040", "name": "HLTF polyubiquitinates monoubiquitinated PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623301", "species_10623270" ], "products": [ "species_10623277", "species_10623264", "species_10623299", "species_10608545" ], "modifiers": [ [ "species_10623301", "catalyst" ] ], "additional_components": [ "Q54T24", "DDB_G0281949", "B0G105", "DDB_G0282115", "Q54SZ4", "DDB_G0282115", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q86K32", "DDB_G0277267", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54D06", "DDB_G0292596", "Q54K47", "DDB_G0287607", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q54T24", "DDB_G0281949", "B0G105", "DDB_G0282115", "Q54SZ4", "DDB_G0282115", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54T24", "DDB_G0281949", "B0G105", "DDB_G0282115", "Q54SZ4", "DDB_G0282115", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596" ] }, "reaction_10623068": { "compartment": "compartment_70101", "id": "reaction_10623068", "reactome": "R-DDI-8938773", "name": "RNF144A polyubiquitinates PRKDC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623060", "species_10623058" ], "products": [ "species_10596492", "species_10623065", "species_10623056" ], "modifiers": [ [ "species_10623060", "catalyst" ] ], "additional_components": [ "Q54TE1", "DDB_G0281833", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54ZG5", "DDB_G0277577", "Q54QC7", "DDB_G0283939", "Q54UC0", "DDB_G0281167", "Q54TE1", "DDB_G0281833", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0281833", "DDB_G0281167", "Q54ZG5", "DDB_G0277577", "Q54QC7", "DDB_G0283939", "Q54TE1", "DDB_G0281833", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54ZG5", "DDB_G0277577", "Q54QC7", "DDB_G0283939", "Q54UC0", "DDB_G0281167" ] }, "reaction_10623916": { "compartment": "compartment_17947", "id": "reaction_10623916", "reactome": "R-DDI-8953946", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623904" ], "products": [ "species_10623913", "species_10577361" ], "modifiers": [ [ "species_10623904", "catalyst" ] ], "additional_components": [ "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54MD1", "DDB_G0286033", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54MD1", "DDB_G0286033", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54MD1", "DDB_G0286033" ] }, "reaction_10619202": { "compartment": "compartment_70101", "id": "reaction_10619202", "reactome": "R-DDI-8853503", "name": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576913" ], "products": [ "species_10579845", "species_10576913" ], "modifiers": [ [ "species_10619199", "catalyst" ] ], "additional_components": [ "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "Q54T48", "DDB_G0282007", "Q869U4", "DDB_G0276443", "Q553T4", "DDB_G0275415" ] }, "reaction_10619233": { "compartment": "compartment_70101", "id": "reaction_10619233", "reactome": "R-DDI-8853515", "name": "OTULIN,USP5 cleaves UBC yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619230" ], "products": [ "species_10577007", "species_10577021", "species_10577035", "species_10576923", "species_10576937", "species_10576951", "species_10576965", "species_10576979", "species_10576993" ], "modifiers": [ [ "species_10610786", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG81", "DDB_G0279721", "P0CG80", "DDB_G0291928", "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "DDB_G0291239" ] }, "reaction_10619237": { "compartment": "compartment_70101", "id": "reaction_10619237", "reactome": "R-DDI-8853529", "name": "OTULIN,USP5 cleaves UBB yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619235" ], "products": [ "species_10576919", "species_10576917", "species_10576915" ], "modifiers": [ [ "species_10610786", "catalyst" ] ], "additional_components": [ "DDB_G0276765", "DDB_G0276765", "DDB_G0276765", "DDB_G0276765", "DDB_G0291239" ] }, "reaction_10619151": { "compartment": "compartment_7660", "id": "reaction_10619151", "reactome": "R-DDI-8852130", "name": "UBA1 conjugates ubiquitin to nuclear E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619115", "species_10619098" ], "products": [ "species_10619149", "species_10619064" ], "modifiers": [], "additional_components": [ "Q54TE1", "DDB_G0281833", "Q54XS6", "DDB_G0278775", "Q54I43", "DDB_G0289021", "Q54F00", "DDB_G0291199", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q55EY8", "DDB_G0268938", "Q553F3", "DDB_G0275787", "Q54VG3", "DDB_G0280347", "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG81", "DDB_G0279721", "P0CG80", "DDB_G0291928", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54I43", "DDB_G0289021", "Q553F3", "DDB_G0275787", "Q54TE1", "DDB_G0281833", "Q54F00", "DDB_G0291199", "Q54J12", "DDB_G0288697", "Q54IK3", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q55EY8", "DDB_G0268938", "Q54VG3", "DDB_G0280347", "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG81", "DDB_G0279721", "P0CG80", "DDB_G0291928", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272" ] }, "reaction_10618924": { "compartment": "compartment_70101", "id": "reaction_10618924", "reactome": "R-DDI-8852127", "name": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618888", "species_10618890" ], "products": [ "species_10618892", "species_10618922" ], "modifiers": [], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG81", "DDB_G0279721", "P14797", "DDB_G0276765", "Q550P6", "DDB_G0277047", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q555G0", "DDB_G0274897", "Q54TE1", "DDB_G0281833", "Q54VG3", "DDB_G0280347", "Q54I43", "DDB_G0289021", "P0CG76", "DDB_G0282295", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG81", "DDB_G0279721", "P14797", "DDB_G0276765", "Q550P6", "DDB_G0277047", "Q54I43", "DDB_G0289021", "Q54TE1", "DDB_G0281833", "Q555G0", "DDB_G0274897", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "Q54VG3", "DDB_G0280347", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765" ] }, "reaction_10619216": { "compartment": "compartment_70101", "id": "reaction_10619216", "reactome": "R-DDI-8853514", "name": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619214" ], "products": [ "species_10580280", "species_10576913" ], "modifiers": [ [ "species_10619199", "catalyst" ] ], "additional_components": [ "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG81", "DDB_G0279721", "P0CG80", "DDB_G0291928", "P0CG88", "DDB_G0269458", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "Q54T48", "DDB_G0282007", "Q869U4", "DDB_G0276443", "Q553T4", "DDB_G0275415" ] }, "reaction_10619153": { "compartment": "compartment_7660", "id": "reaction_10619153", "reactome": "R-DDI-8852131", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10619096", "species_10576865" ], "products": [ "species_10619098", "species_113541" ], "modifiers": [], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG81", "DDB_G0279721", "P0CG80", "DDB_G0291928", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272" ] }, "reaction_10619094": { "compartment": "compartment_70101", "id": "reaction_10619094", "reactome": "R-DDI-8852129", "name": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619068", "species_10619072" ], "products": [ "species_10619092", "species_10619074" ], "modifiers": [], "additional_components": [ "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54XS6", "DDB_G0278775", "Q54VW9", "DDB_G0280091", "Q54VG3", "DDB_G0280347", "Q75JE1", "DDB_G0271726", "Q54TE1", "DDB_G0281833", "Q54I43", "DDB_G0289021", "P0CG76", "DDB_G0282295", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG81", "DDB_G0279721", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272", "Q54I43", "DDB_G0289021", "Q54TE1", "DDB_G0281833", "Q54VG3", "DDB_G0280347", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "Q75JE1", "DDB_G0271726", "Q54XS6", "DDB_G0278775", "Q54VW9", "DDB_G0280091", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG81", "DDB_G0279721", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272" ] }, "reaction_10619159": { "compartment": "compartment_70101", "id": "reaction_10619159", "reactome": "R-DDI-8852133", "name": "UBA1 conjugates ubiquitin to UBA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619074" ], "products": [ "species_10619070", "species_76577" ], "modifiers": [ [ "species_10619074", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG81", "DDB_G0279721", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272", "Q55C16", "DDB_G0270272", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG81", "DDB_G0279721", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272" ] }, "reaction_10619156": { "compartment": "compartment_70101", "id": "reaction_10619156", "reactome": "R-DDI-8852132", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619070", "species_10577037", "species_113592" ], "products": [ "species_111294", "species_10619072" ], "modifiers": [ [ "species_10619070", "catalyst" ] ], "additional_components": [ "Q55C16", "DDB_G0270272", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG81", "DDB_G0279721", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272", "Q55C16", "DDB_G0270272", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765" ] }, "reaction_10619162": { "compartment": "compartment_70101", "id": "reaction_10619162", "reactome": "R-DDI-8852134", "name": "UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_113592", "species_10596583" ], "products": [ "species_111294", "species_10619074" ], "modifiers": [ [ "species_10596583", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0270272", "P0CG76", "DDB_G0282295", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG81", "DDB_G0279721", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272", "DDB_G0270272" ] }, "reaction_10619066": { "compartment": "compartment_7660", "id": "reaction_10619066", "reactome": "R-DDI-8852128", "name": "UBA1 adenylates ubiquitin in the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10618926", "species_10576865" ], "products": [ "species_10619064", "species_113541" ], "modifiers": [], "additional_components": [ "DDB_G0270272", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG81", "DDB_G0279721", "P0CG80", "DDB_G0291928", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272" ] }, "reaction_10619164": { "compartment": "compartment_7660", "id": "reaction_10619164", "reactome": "R-DDI-8852136", "name": "UBA1 conjugates ubiquitin to UBA1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619064" ], "products": [ "species_164121", "species_10619096" ], "modifiers": [], "additional_components": [ "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG81", "DDB_G0279721", "P0CG80", "DDB_G0291928", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272" ] }, "reaction_10594387": { "compartment": "compartment_17963", "id": "reaction_10594387", "reactome": "R-DDI-914005", "name": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10594356" ], "products": [ "species_205687", "species_10594385" ], "modifiers": [], "additional_components": [ "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357", "Q54ZU4", "DDB_G0277357", "Q54KS2", "DDB_G0287193" ] }, "reaction_10594407": { "compartment": "compartment_17963", "id": "reaction_10594407", "reactome": "R-DDI-914008", "name": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10594356" ], "products": [ "species_205687", "species_10594405" ], "modifiers": [], "additional_components": [ "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357", "Q54ZU4", "DDB_G0277357", "Q54KS2", "DDB_G0287193" ] }, "reaction_10594441": { "compartment": "compartment_17963", "id": "reaction_10594441", "reactome": "R-DDI-914017", "name": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10594356" ], "products": [ "species_10594439", "species_205687" ], "modifiers": [], "additional_components": [ "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357", "Q54ZU4", "DDB_G0277357", "Q54KS2", "DDB_G0287193" ] }, "reaction_10594397": { "compartment": "compartment_17963", "id": "reaction_10594397", "reactome": "R-DDI-914006", "name": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10594356" ], "products": [ "species_10594395", "species_205687" ], "modifiers": [], "additional_components": [ "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357", "Q54ZU4", "DDB_G0277357", "Q54KS2", "DDB_G0287193" ] }, "reaction_10603666": { "compartment": "compartment_12045", "id": "reaction_10603666", "reactome": "R-DDI-4419978", "name": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362", "species_4419987" ], "products": [ "species_4419982" ], "modifiers": [ [ "species_10603663", "catalyst" ] ], "additional_components": [ "Q54EN3", "DDB_G0291436", "Q55AK1", "DDB_G0271830" ] }, "reaction_10603674": { "compartment": "compartment_12045", "id": "reaction_10603674", "reactome": "R-DDI-4419979", "name": "SRD5A3 reduces pPNOL to DCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_4419981", "species_29364" ], "products": [ "species_29366", "species_449221" ], "modifiers": [ [ "species_10603671", "catalyst" ] ], "additional_components": [ "DDB_G0284423" ] }, "reaction_10592733": { "compartment": "compartment_12045", "id": "reaction_10592733", "reactome": "R-DDI-446195", "name": "DOLK phosphorylates DCHOL to DOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_449221" ], "products": [ "species_110094", "species_449299" ], "modifiers": [ [ "species_10592730", "catalyst" ] ], "additional_components": [ "DDB_G0285689" ] }, "reaction_10592749": { "compartment": "compartment_12045", "id": "reaction_10592749", "reactome": "R-DDI-446200", "name": "DOLPP1 dephosphorylates DOLDP to DOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_449744" ], "products": [ "species_29372", "species_449299" ], "modifiers": [ [ "species_10592746", "catalyst" ] ], "additional_components": [ "DDB_G0274591" ] }, "reaction_10592768": { "compartment": "compartment_70101", "id": "reaction_10592768", "reactome": "R-DDI-446201", "name": "PMM1,2 isomerise Man6P to Man1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_532562" ], "products": [ "species_532531" ], "modifiers": [ [ "species_10592765", "catalyst" ] ], "additional_components": [ "Q54X03", "DDB_G0279289", "Q86B09", "DDB_G0272781" ] }, "reaction_10593934": { "compartment": "compartment_70101", "id": "reaction_10593934", "reactome": "R-DDI-532549", "name": "MPI isomerises Fru6P to Man6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512" ], "products": [ "species_532562" ], "modifiers": [ [ "species_10593931", "catalyst" ] ], "additional_components": [ "DDB_G0284685" ] }, "reaction_10592802": { "compartment": "compartment_12045", "id": "reaction_10592802", "reactome": "R-DDI-446214", "name": "Synthesis of dolichyl-phosphate-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449299", "species_29410" ], "products": [ "species_532214", "species_110096" ], "modifiers": [ [ "species_10592799", "catalyst" ] ], "additional_components": [ "DDB_G0288321" ] }, "reaction_10591655": { "compartment": "compartment_17938", "id": "reaction_10591655", "reactome": "R-DDI-428585", "name": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428040", "species_428639" ], "products": [ "species_428633", "species_70106" ], "modifiers": [ [ "species_10591652", "catalyst" ] ], "additional_components": [ "DDB_G0280761" ] }, "reaction_10612709": { "compartment": "compartment_70101", "id": "reaction_10612709", "reactome": "R-DDI-6787540", "name": "FUK phosphorylates beta-Fuc to Fuc1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6787678" ], "products": [ "species_29370", "species_6787542" ], "modifiers": [ [ "species_10612706", "catalyst" ] ], "additional_components": [ "DDB_G0269678" ] }, "reaction_10612727": { "compartment": "compartment_70101", "id": "reaction_10612727", "reactome": "R-DDI-6787632", "name": "GMDS dehydrates GDP-Man to GDP-DHDMan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860" ], "products": [ "species_29356", "species_6787618" ], "modifiers": [ [ "species_10612724", "catalyst" ] ], "additional_components": [ "DDB_G0284553" ] }, "reaction_10594121": { "compartment": "compartment_20699", "id": "reaction_10594121", "reactome": "R-DDI-742345", "name": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742368" ], "products": [ "species_205683" ], "modifiers": [ [ "species_10594118", "catalyst" ] ], "additional_components": [ "DDB_G0277007" ] }, "reaction_10612730": { "compartment": "compartment_70101", "id": "reaction_10612730", "reactome": "R-DDI-6787642", "name": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_6787646", "species_29364" ], "products": [ "species_742368", "species_29366" ], "modifiers": [ [ "species_10612716", "catalyst" ] ], "additional_components": [ "Q55C77", "DDB_G0270184" ] }, "reaction_10612701": { "compartment": "compartment_70101", "id": "reaction_10612701", "reactome": "R-DDI-6787533", "name": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_6787542" ], "products": [ "species_111294", "species_742368" ], "modifiers": [ [ "species_10612698", "catalyst" ] ], "additional_components": [ "DDB_G0285257" ] }, "reaction_10612719": { "compartment": "compartment_70101", "id": "reaction_10612719", "reactome": "R-DDI-6787623", "name": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787618" ], "products": [ "species_6787646" ], "modifiers": [ [ "species_10612716", "catalyst" ] ], "additional_components": [ "Q55C77", "DDB_G0270184" ] }, "reaction_10592786": { "compartment": "compartment_70101", "id": "reaction_10592786", "reactome": "R-DDI-446204", "name": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29494", "species_532204" ], "products": [ "species_111294", "species_162756" ], "modifiers": [ [ "species_10592783", "catalyst" ] ], "additional_components": [ "Q54GN5", "DDB_G0290055" ] }, "reaction_10593001": { "compartment": "compartment_70101", "id": "reaction_10593001", "reactome": "R-DDI-449734", "name": "Acetylation of glucosamine 6-phosphate to GlcNAc6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183", "species_449701" ], "products": [ "species_76194", "species_449703" ], "modifiers": [ [ "species_10592998", "catalyst" ] ], "additional_components": [ "Q54WR8", "DDB_G0279475" ] }, "reaction_10592991": { "compartment": "compartment_70101", "id": "reaction_10592991", "reactome": "R-DDI-449715", "name": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512", "species_29472" ], "products": [ "species_29404", "species_449701" ], "modifiers": [ [ "species_10592988", "catalyst" ] ], "additional_components": [ "Q54LK1", "DDB_G0286603" ] }, "reaction_10592725": { "compartment": "compartment_12045", "id": "reaction_10592725", "reactome": "R-DDI-446191", "name": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162756", "species_449299" ], "products": [ "species_109402", "species_449222" ], "modifiers": [ [ "species_10592722", "catalyst" ] ], "additional_components": [ "DDB_G0290751" ] }, "reaction_10592741": { "compartment": "compartment_17957", "id": "reaction_10592741", "reactome": "R-DDI-446198", "name": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449312" ], "products": [ "species_449311", "species_449365" ], "modifiers": [ [ "species_10592738", "catalyst" ], [ "species_10592706", "catalyst" ] ], "additional_components": [ "DDB_G0267884", "DDB_G0295677" ] }, "reaction_10592820": { "compartment": "compartment_12045", "id": "reaction_10592820", "reactome": "R-DDI-446218", "name": "Addition of the first mannose to the N-glycan precursor by ALG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449293" ], "products": [ "species_29420", "species_449283" ], "modifiers": [ [ "species_10592817", "catalyst" ] ], "additional_components": [ "DDB_G0286011" ] }, "reaction_10592708": { "compartment": "compartment_17957", "id": "reaction_10592708", "reactome": "R-DDI-446188", "name": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449298" ], "products": [ "species_449311", "species_449315" ], "modifiers": [ [ "species_10592700", "catalyst" ], [ "species_10592706", "catalyst" ] ], "additional_components": [ "DDB_G0268238", "DDB_G0295677" ] }, "reaction_10592776": { "compartment": "compartment_17957", "id": "reaction_10592776", "reactome": "R-DDI-446202", "name": "Addition of the first glucose to the N-glycan precursor by ALG6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449371", "species_532542" ], "products": [ "species_449311", "species_449649" ], "modifiers": [ [ "species_10592773", "catalyst" ] ], "additional_components": [ "DDB_G0283841" ] }, "reaction_10592794": { "compartment": "compartment_12045", "id": "reaction_10592794", "reactome": "R-DDI-446208", "name": "Addition of a second mannose to the N-glycan precursor by ALG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449283" ], "products": [ "species_449737", "species_29420" ], "modifiers": [ [ "species_10592791", "catalyst" ] ], "additional_components": [ "DDB_G0272730" ] }, "reaction_10592810": { "compartment": "compartment_17957", "id": "reaction_10592810", "reactome": "R-DDI-446215", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449315" ], "products": [ "species_449311", "species_449312" ], "modifiers": [ [ "species_10592807", "catalyst" ], [ "species_10592706", "catalyst" ] ], "additional_components": [ "DDB_G0279349", "DDB_G0295677" ] }, "reaction_10592717": { "compartment": "compartment_17957", "id": "reaction_10592717", "reactome": "R-DDI-446189", "name": "Addition of a second glucose to the N-glycan precursor by ALG8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449649", "species_532542" ], "products": [ "species_449311", "species_449638" ], "modifiers": [ [ "species_10592714", "catalyst" ] ], "additional_components": [ "DDB_G0275261" ] }, "reaction_10592812": { "compartment": "compartment_17957", "id": "reaction_10592812", "reactome": "R-DDI-446216", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449365" ], "products": [ "species_449371", "species_449311" ], "modifiers": [ [ "species_10592807", "catalyst" ], [ "species_10592706", "catalyst" ] ], "additional_components": [ "DDB_G0279349", "DDB_G0295677" ] }, "reaction_10619185": { "compartment": "compartment_70101", "id": "reaction_10619185", "reactome": "R-DDI-8853379", "name": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10596971" ], "products": [ "species_8853371", "species_8853381" ], "modifiers": [ [ "species_10619182", "catalyst" ] ], "additional_components": [ "CHEBI:60627", "CHEBI:60628", "species_915149", "CHEBI:60629", "species_964740", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "species_8853396", "species_6799540", "CHEBI:91283", "CHEBI:91282", "CHEBI:91281", "DDB_G0268520" ] }, "reaction_10596973": { "compartment": "compartment_70101", "id": "reaction_10596973", "reactome": "R-DDI-1022127", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596969" ], "products": [ "species_10596971" ], "modifiers": [], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "CHEBI:60627", "CHEBI:60628", "species_915149", "CHEBI:60629", "species_964740", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765" ] }, "reaction_10594300": { "compartment": "compartment_17957", "id": "reaction_10594300", "reactome": "R-DDI-901047", "name": "Binding of ERp57", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594296", "species_10594000" ], "products": [ "species_10594298" ], "modifiers": [], "additional_components": [ "CHEBI:59080", "Q55BA8", "DDB_G0271144", "Q23858", "DDB_G0283539", "DDB_G0291434", "Q54EN4", "DDB_G0291434", "CHEBI:59080", "Q55BA8", "DDB_G0271144", "Q23858", "DDB_G0283539" ] }, "reaction_10595778": { "compartment": "compartment_20699", "id": "reaction_10595778", "reactome": "R-DDI-975814", "name": "Trimming of mannoses on the alpha1,6 arm by MAN2A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964837" ], "products": [ "species_964752", "species_975819" ], "modifiers": [ [ "species_10595775", "catalyst" ] ], "additional_components": [ "Q54KN4", "DDB_G0287231", "species_29426" ] }, "reaction_10596981": { "compartment": "compartment_20699", "id": "reaction_10596981", "reactome": "R-DDI-1028788", "name": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975910", "species_205683" ], "products": [ "species_205689", "species_1028779" ], "modifiers": [ [ "species_10596978", "catalyst" ] ], "additional_components": [ "DDB_G0278473" ] }, "reaction_10611509": { "compartment": "compartment_17963", "id": "reaction_10611509", "reactome": "R-DDI-5693925", "name": "FUT3 transfers L-fucose to Gal1,3GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693930", "species_205683" ], "products": [ "species_5693933", "species_205689" ], "modifiers": [ [ "species_10611506", "catalyst" ] ], "additional_components": [ "Q54PK0", "DDB_G0284775", "Q86J24", "DDB_G0284775", "Q54P60", "DDB_G0284775", "Q54PH9", "DDB_G0284467", "Q54PK3", "DDB_G0284551", "Q54RA6", "DDB_G0284775", "Q54PJ9", "DDB_G0284775" ] }, "reaction_10611469": { "compartment": "compartment_161320", "id": "reaction_10611469", "reactome": "R-DDI-5693807", "name": "FUCA1 hydrolyses NGP:1,6-GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_6784247" ], "products": [ "species_6784248", "species_6784249" ], "modifiers": [ [ "species_10611466", "catalyst" ] ], "additional_components": [ "P10901", "DDB_G0274391", "Q551C1", "DDB_G0276661" ] }, "reaction_10595786": { "compartment": "compartment_17963", "id": "reaction_10595786", "reactome": "R-DDI-975926", "name": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_975910" ], "products": [ "species_981613" ], "modifiers": [ [ "species_10595783", "catalyst" ] ], "additional_components": [ "DDB_G0272422" ] }, "reaction_10620710": { "compartment": "compartment_70101", "id": "reaction_10620710", "reactome": "R-DDI-8870457", "name": "FarC-PTP4A2 binds RABGGTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620704", "species_10620706" ], "products": [ "species_10620708" ], "modifiers": [], "additional_components": [ "Q54DU9", "DDB_G0292024", "Q86IL4", "DDB_G0292024", "DDB_G0290671", "B0G172", "DDB_G0290671", "Q54DU9", "DDB_G0292024", "Q86IL4", "DDB_G0292024" ] }, "reaction_10620725": { "compartment": "compartment_70101", "id": "reaction_10620725", "reactome": "R-DDI-8870465", "name": "RGGT binds the RAB-binding subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1131164", "species_10620714", "species_10620721" ], "products": [ "species_10620723" ], "modifiers": [], "additional_components": [ "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "Q54VT9", "DDB_G0280143", "Q54VT9", "DDB_G0280143", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "species_1131164" ] }, "reaction_10621957": { "compartment": "compartment_70101", "id": "reaction_10621957", "reactome": "R-DDI-8870469", "name": "RGGT geranylgeranylates RAB proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1131164", "species_10621130" ], "products": [ "species_1132084", "species_10621952", "species_10621954" ], "modifiers": [ [ "species_10621130", "catalyst" ] ], "additional_components": [ "Q54VT9", "DDB_G0280143", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "species_1131164", "Q86JP3", "DDB_G0271984", "Q54RY4", "DDB_G0282899", "P20790", "DDB_G0280043", "Q1ZXE7", "DDB_G0286169", "P20791", "DDB_G0276399", "P36409", "DDB_G0292268", "Q8MXQ2", "DDB_G0275675", "Q1ZXC0", "DDB_G0290827", "Q54QR3", "DDB_G0283603", "P36412", "DDB_G0269238", "P34139", "DDB_G0283757", "Q86JP0", "DDB_G0294583", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "species_29420", "Q54VT9", "DDB_G0280143", "species_29420", "Q8MXQ2", "DDB_G0275675", "Q1ZXC0", "DDB_G0290827", "Q54QR3", "DDB_G0283603", "P34139", "DDB_G0283757", "P36412", "DDB_G0269238", "P34143", "DDB_G0271736", "Q558I0", "DDB_G0272905", "Q54EW9", "DDB_G0291293", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "Q54NU2", "DDB_G0284985", "P34141", "DDB_G0291233", "Q552K3", "DDB_G0275969", "P36409", "DDB_G0292268", "Q86JP0", "DDB_G0294583", "Q1ZXE7", "DDB_G0286169", "P20791", "DDB_G0276399", "Q54RY4", "DDB_G0282899", "P20790", "DDB_G0280043", "Q86JP3", "DDB_G0271984", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "species_1131164", "Q54VT9", "DDB_G0280143", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "species_1131164", "Q86JP3", "DDB_G0271984", "Q54RY4", "DDB_G0282899", "P20790", "DDB_G0280043", "Q1ZXE7", "DDB_G0286169", "P20791", "DDB_G0276399", "P36409", "DDB_G0292268", "Q8MXQ2", "DDB_G0275675", "Q1ZXC0", "DDB_G0290827", "Q54QR3", "DDB_G0283603", "P36412", "DDB_G0269238", "P34139", "DDB_G0283757", "Q86JP0", "DDB_G0294583", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "species_29420" ] }, "reaction_10620716": { "compartment": "compartment_70101", "id": "reaction_10620716", "reactome": "R-DDI-8870461", "name": "RABGGTA and RABGGTB bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620712", "species_10620706" ], "products": [ "species_10620714" ], "modifiers": [ [ "species_10620708", "inhibitor" ] ], "additional_components": [ "DDB_G0269570", "DDB_G0290671", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "B0G172", "DDB_G0290671", "Q54DU9", "DDB_G0292024", "Q86IL4", "DDB_G0292024" ] }, "reaction_10621132": { "compartment": "compartment_70101", "id": "reaction_10621132", "reactome": "R-DDI-8870466", "name": "RGGT:CHM binds RABs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10621128", "species_10620723" ], "products": [ "species_10621130" ], "modifiers": [], "additional_components": [ "Q86JP3", "DDB_G0271984", "Q54RY4", "DDB_G0282899", "P20790", "DDB_G0280043", "Q1ZXE7", "DDB_G0286169", "P20791", "DDB_G0276399", "P36409", "DDB_G0292268", "Q8MXQ2", "DDB_G0275675", "Q1ZXC0", "DDB_G0290827", "Q54QR3", "DDB_G0283603", "P36412", "DDB_G0269238", "P34139", "DDB_G0283757", "Q86JP0", "DDB_G0294583", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "species_29420", "Q54VT9", "DDB_G0280143", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "species_1131164", "Q54VT9", "DDB_G0280143", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "species_1131164", "Q86JP3", "DDB_G0271984", "Q54RY4", "DDB_G0282899", "P20790", "DDB_G0280043", "Q1ZXE7", "DDB_G0286169", "P20791", "DDB_G0276399", "P36409", "DDB_G0292268", "Q8MXQ2", "DDB_G0275675", "Q1ZXC0", "DDB_G0290827", "Q54QR3", "DDB_G0283603", "P36412", "DDB_G0269238", "P34139", "DDB_G0283757", "Q86JP0", "DDB_G0294583", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "species_29420" ] }, "reaction_10583985": { "compartment": "compartment_70101", "id": "reaction_10583985", "reactome": "R-DDI-162857", "name": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855657", "species_29356" ], "products": [ "species_8855661", "species_29416" ], "modifiers": [ [ "species_10583982", "catalyst" ] ], "additional_components": [ "DDB_G0293136" ] }, "reaction_10583923": { "compartment": "compartment_70101", "id": "reaction_10583923", "reactome": "R-DDI-162730", "name": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426639", "species_162756" ], "products": [ "species_8855657", "species_110096" ], "modifiers": [ [ "species_10583920", "catalyst" ] ], "additional_components": [ "Q86K35", "DDB_G0277289", "Q86JM6", "DDB_G0272006", "Q556K9", "DDB_G0272588", "Q54QB2", "DDB_G0283965", "Q54M40", "DDB_G0286221", "Q54WP5", "DDB_G0279515" ] }, "reaction_10583954": { "compartment": "compartment_12045", "id": "reaction_10583954", "reactome": "R-DDI-162798", "name": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855659", "species_1500581" ], "products": [ "species_8855663", "species_1500596" ], "modifiers": [ [ "species_10583951", "catalyst" ] ], "additional_components": [ "DDB_G0279313" ] }, "reaction_10583938": { "compartment": "compartment_12045", "id": "reaction_10583938", "reactome": "R-DDI-162742", "name": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855660" ], "products": [ "species_8855660" ], "modifiers": [ [ "species_10583935", "catalyst" ] ], "additional_components": [ "Q54PB0", "DDB_G0284667", "Q551Y7", "DDB_G0276251" ] }, "reaction_10583977": { "compartment": "compartment_12045", "id": "reaction_10583977", "reactome": "R-DDI-162830", "name": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_8855665" ], "products": [ "species_8855659", "species_162872" ], "modifiers": [ [ "species_10583974", "catalyst" ] ], "additional_components": [ "Q54QP2", "DDB_G0283717", "Q54IA4", "DDB_G0288899" ] }, "reaction_10583993": { "compartment": "compartment_12045", "id": "reaction_10583993", "reactome": "R-DDI-162873", "name": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_8855663" ], "products": [ "species_162872", "species_8855667" ], "modifiers": [ [ "species_10583990", "catalyst" ] ], "additional_components": [ "DDB_G0280891" ] }, "reaction_10583962": { "compartment": "compartment_12045", "id": "reaction_10583962", "reactome": "R-DDI-162821", "name": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_8855667" ], "products": [ "species_8855656", "species_162872" ], "modifiers": [ [ "species_10583959", "catalyst" ] ], "additional_components": [ "DDB_G0284435" ] }, "reaction_10583946": { "compartment": "compartment_12045", "id": "reaction_10583946", "reactome": "R-DDI-162797", "name": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855656", "species_449229" ], "products": [ "species_8855664" ], "modifiers": [ [ "species_10583943", "catalyst" ] ], "additional_components": [ "DDB_G0291660" ] }, "reaction_10583871": { "compartment": "compartment_17957", "id": "reaction_10583871", "reactome": "R-DDI-162683", "name": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_8855661" ], "products": [ "species_8855666", "species_76194" ], "modifiers": [ [ "species_10583868", "catalyst" ] ], "additional_components": [ "DDB_G0286111" ] }, "reaction_10623183": { "compartment": "compartment_984", "id": "reaction_10623183", "reactome": "R-DDI-8940388", "name": "GPLD1 hydrolyses GPI-anchors from proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10623153" ], "products": [ "species_10623175", "species_2197633" ], "modifiers": [ [ "species_10623180", "catalyst" ] ], "additional_components": [ "Q55E77", "DDB_G0270488", "Q54WG1", "DDB_G0279675", "Q54I77", "DDB_G0288963", "Q54G06", "DDB_G0290501", "Q54WG1", "DDB_G0279675", "Q55E77", "DDB_G0270488", "Q54I77", "DDB_G0288963", "Q54G06", "DDB_G0290501", "DDB_G0276919" ] }, "reaction_10605201": { "compartment": "compartment_70101", "id": "reaction_10605201", "reactome": "R-DDI-5358475", "name": "DPH6 ligates ammonium to diphthine-EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10605193", "species_31633" ], "products": [ "species_111294", "species_10583767", "species_76577" ], "modifiers": [ [ "species_10605198", "catalyst" ] ], "additional_components": [ "DDB_G0288373", "DDB_G0288373", "DDB_G0278373" ] }, "reaction_10605237": { "compartment": "compartment_70101", "id": "reaction_10605237", "reactome": "R-DDI-5358494", "name": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10605217" ], "products": [ "species_353106", "species_10605204" ], "modifiers": [ [ "species_10605234", "catalyst" ] ], "additional_components": [ "DDB_G0288373", "DDB_G0288373", "Q7KWL8", "DDB_G0277061", "Q54PW5", "DDB_G0284257", "B0G132", "DDB_G0295687" ] }, "reaction_10605215": { "compartment": "compartment_70101", "id": "reaction_10605215", "reactome": "R-DDI-5358484", "name": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10605204" ], "products": [ "species_10605207", "species_71285" ], "modifiers": [ [ "species_10605212", "catalyst" ] ], "additional_components": [ "DDB_G0288373", "DDB_G0288373", "DDB_G0276115" ] }, "reaction_10612822": { "compartment": "compartment_12045", "id": "reaction_10612822", "reactome": "R-DDI-6788650", "name": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788753", "species_71284" ], "products": [ "species_71285", "species_6788758" ], "modifiers": [ [ "species_10612819", "catalyst" ] ], "additional_components": [ "Q558K8", "DDB_G0272799", "species_29426" ] }, "reaction_10588135": { "compartment": "compartment_70101", "id": "reaction_10588135", "reactome": "R-DDI-204662", "name": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_10588102", "species_73473" ], "products": [ "species_29356", "species_10588123", "species_29360" ], "modifiers": [ [ "species_10588132", "catalyst" ] ], "additional_components": [ "DDB_G0284861", "DDB_G0284861", "Q556G4", "DDB_G0272634", "species_71067" ] }, "reaction_10588118": { "compartment": "compartment_70101", "id": "reaction_10588118", "reactome": "R-DDI-204617", "name": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_204628", "species_10588102", "species_73473" ], "products": [ "species_10588106", "species_204635", "species_29360" ], "modifiers": [ [ "species_10588115", "catalyst" ] ], "additional_components": [ "DDB_G0284861", "DDB_G0284861", "Q54MQ7", "DDB_G0285725" ] }, "reaction_10621975": { "compartment": "compartment_70101", "id": "reaction_10621975", "reactome": "R-DDI-8873946", "name": "OTUD3 deubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10621972" ], "products": [ "species_10587224" ], "modifiers": [ [ "species_10616721", "catalyst" ] ], "additional_components": [ "DDB_G0286557", "DDB_G0286557", "DDB_G0267906" ] }, "reaction_10612360": { "compartment": "compartment_70101", "id": "reaction_10612360", "reactome": "R-DDI-6781953", "name": "YOD1 binds VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605038", "species_10612356" ], "products": [ "species_10612358" ], "modifiers": [], "additional_components": [ "DDB_G0288065", "DDB_G0271346", "Q55BI3", "DDB_G0271346", "P90532", "DDB_G0288065" ] }, "reaction_10611237": { "compartment": "compartment_7660", "id": "reaction_10611237", "reactome": "R-DDI-5691381", "name": "MYSM1 deubiquitinates Histone H2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10611232" ], "products": [ "species_10611234", "species_10576865" ], "modifiers": [ [ "species_10611232", "catalyst" ] ], "additional_components": [ "Q54R05", "DDB_G0283459", "Q54J55", "DDB_G0288285", "Q550R6", "DDB_G0277033", "Q54R05", "DDB_G0283459", "Q54J55", "DDB_G0288285", "Q550R6", "DDB_G0277033", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R05", "DDB_G0283459", "Q54J55", "DDB_G0288285", "Q550R6", "DDB_G0277033" ] }, "reaction_10611958": { "compartment": "compartment_70101", "id": "reaction_10611958", "reactome": "R-DDI-5696547", "name": "STAMBPL1 is a deubiquitinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584754" ], "products": [ "species_10584752" ], "modifiers": [ [ "species_10611955", "catalyst" ] ], "additional_components": [ "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "DDB_G0284037" ] }, "reaction_10611240": { "compartment": "compartment_70101", "id": "reaction_10611240", "reactome": "R-DDI-5691431", "name": "PSMD14 cleaves K63-linked ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584754" ], "products": [ "species_10584752" ], "modifiers": [ [ "species_10577042", "catalyst" ] ], "additional_components": [ "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "DDB_G0272566" ] }, "reaction_10612001": { "compartment": "compartment_70101", "id": "reaction_10612001", "reactome": "R-DDI-5696600", "name": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10611992" ], "products": [ "species_10611998", "species_10609754" ], "modifiers": [ [ "species_10611992", "catalyst" ] ], "additional_components": [ "Q54QM6", "DDB_G0283617", "Q86L44", "DDB_G0294407", "Q86J16", "DDB_G0274827", "Q86J16", "DDB_G0274827", "Q86L44", "DDB_G0294407", "Q54QM6", "DDB_G0283617", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54QM6", "DDB_G0283617", "Q86L44", "DDB_G0294407", "Q86J16", "DDB_G0274827" ] }, "reaction_10610823": { "compartment": "compartment_7660", "id": "reaction_10610823", "reactome": "R-DDI-5690157", "name": "USP16,USP21 deubiquitinate Histone H2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10610818" ], "products": [ "species_10610820", "species_10576865" ], "modifiers": [ [ "species_10610818", "catalyst" ] ], "additional_components": [ "Q55EJ1", "DDB_G0268872", "Q86KB3", "DDB_G0274207", "Q55EJ1", "DDB_G0268872", "Q86KB3", "DDB_G0274207", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55EJ1", "DDB_G0268872", "Q86KB3", "DDB_G0274207" ] }, "reaction_10609766": { "compartment": "compartment_70101", "id": "reaction_10609766", "reactome": "R-DDI-5689539", "name": "ADRM1:26S proteaseome binds USP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606645", "species_10609762" ], "products": [ "species_10609764" ], "modifiers": [], "additional_components": [ "Q556N5", "DDB_G0272624", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408", "DDB_G0271264", "Q55BC4", "DDB_G0271264", "Q556N5", "DDB_G0272624", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10610793": { "compartment": "compartment_70101", "id": "reaction_10610793", "reactome": "R-DDI-5690152", "name": "USP5 cleaves polyubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10610788" ], "products": [ "species_10577037", "species_10610790" ], "modifiers": [ [ "species_10610788", "catalyst" ] ], "additional_components": [ "P54201", "DDB_G0291239", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P54201", "DDB_G0291239", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P54201", "DDB_G0291239", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295" ] }, "reaction_10612299": { "compartment": "compartment_70101", "id": "reaction_10612299", "reactome": "R-DDI-6781814", "name": "USP19 deubiquitinates RNF123", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10612294" ], "products": [ "species_10612296", "species_10584754" ], "modifiers": [ [ "species_10612294", "catalyst" ] ], "additional_components": [ "B0G199", "DDB_G0293770", "Q54PQ7", "DDB_G0293770", "Q54N05", "DDB_G0285581", "B0G199", "DDB_G0293770", "Q54PQ7", "DDB_G0293770", "Q54N05", "DDB_G0285581", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "B0G199", "DDB_G0293770", "Q54PQ7", "DDB_G0293770", "Q54N05", "DDB_G0285581" ] }, "reaction_10611978": { "compartment": "compartment_70101", "id": "reaction_10611978", "reactome": "R-DDI-5696564", "name": "USP25 deubiquitinates DDX58", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611966", "species_29356" ], "products": [ "species_10609754", "species_10611968" ], "modifiers": [ [ "species_10611966", "catalyst" ] ], "additional_components": [ "Q54DT4", "DDB_G0292046", "Q553T4", "DDB_G0275415", "Q86L44", "DDB_G0294407", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q86L44", "DDB_G0294407", "Q54DT4", "DDB_G0292046", "Q553T4", "DDB_G0275415", "Q54DT4", "DDB_G0292046", "Q553T4", "DDB_G0275415", "Q86L44", "DDB_G0294407" ] }, "reaction_10612202": { "compartment": "compartment_7660", "id": "reaction_10612202", "reactome": "R-DDI-5696958", "name": "USP44 deubiquitinates CDC20", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10612197" ], "products": [ "species_10610745", "species_10612199" ], "modifiers": [ [ "species_10612197", "catalyst" ] ], "additional_components": [ "Q54MZ3", "DDB_G0285601", "Q55EJ1", "DDB_G0268872", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55EJ1", "DDB_G0268872", "Q54MZ3", "DDB_G0285601", "Q54MZ3", "DDB_G0285601", "Q55EJ1", "DDB_G0268872" ] }, "reaction_10612234": { "compartment": "compartment_7660", "id": "reaction_10612234", "reactome": "R-DDI-5696960", "name": "USP49 deubiquitinates H2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10612229" ], "products": [ "species_10612231", "species_10576865" ], "modifiers": [ [ "species_10612229", "catalyst" ] ], "additional_components": [ "Q55EJ1", "DDB_G0268872", "Q55EJ1", "DDB_G0268872", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55EJ1", "DDB_G0268872" ] }, "reaction_10620654": { "compartment": "compartment_70101", "id": "reaction_10620654", "reactome": "R-DDI-8869456", "name": "USP4 deubiquitinate TRAF2,TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10620649" ], "products": [ "species_10609754", "species_10620651" ], "modifiers": [ [ "species_10611973", "catalyst" ] ], "additional_components": [ "B0G199", "DDB_G0293770", "Q54FB9", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54YP8", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "DDB_G0293770" ] }, "reaction_10612268": { "compartment": "compartment_7660", "id": "reaction_10612268", "reactome": "R-DDI-5697009", "name": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10612261" ], "products": [ "species_10610745", "species_10612265" ], "modifiers": [ [ "species_10612261", "catalyst" ] ], "additional_components": [ "Q54C28", "DDB_G0293226", "P34124", "DDB_G0292382", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54C28", "DDB_G0293226", "P34124", "DDB_G0292382", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "Q54C28", "DDB_G0293226", "P34124", "DDB_G0292382", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493" ] }, "reaction_10612468": { "compartment": "compartment_7660", "id": "reaction_10612468", "reactome": "R-DDI-6782820", "name": "USP17 deubiquitinates SUDS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10612463" ], "products": [ "species_10610329", "species_10612465" ], "modifiers": [ [ "species_10612463", "catalyst" ] ], "additional_components": [ "Q86J16", "DDB_G0274827", "Q54PU3", "DDB_G0284289", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54PU3", "DDB_G0284289", "Q86J16", "DDB_G0274827", "Q86J16", "DDB_G0274827", "Q54PU3", "DDB_G0284289" ] }, "reaction_10612280": { "compartment": "compartment_70101", "id": "reaction_10612280", "reactome": "R-DDI-6781779", "name": "USP13 deubiquitinates BECN1,USP10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10612275" ], "products": [ "species_10612277", "species_10584754" ], "modifiers": [ [ "species_10612275", "catalyst" ] ], "additional_components": [ "Q54JI9", "DDB_G0288021", "P54201", "DDB_G0291239", "Q54JI9", "DDB_G0288021", "P54201", "DDB_G0291239", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54JI9", "DDB_G0288021", "P54201", "DDB_G0291239" ] }, "reaction_10612155": { "compartment": "compartment_70101", "id": "reaction_10612155", "reactome": "R-DDI-5696627", "name": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10612104" ], "products": [ "species_10612152", "species_10584754" ], "modifiers": [ [ "species_10612104", "catalyst" ] ], "additional_components": [ "Q54XX5", "DDB_G0278535", "Q54FC5", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "P11467", "DDB_G0290961", "Q1ZXR0", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54ZW5", "DDB_G0277345", "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54XX5", "DDB_G0278535", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54XX5", "DDB_G0278535", "Q54FC5", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "P11467", "DDB_G0290961", "Q1ZXR0", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54ZW5", "DDB_G0277345" ] }, "reaction_10610842": { "compartment": "compartment_70101", "id": "reaction_10610842", "reactome": "R-DDI-5690159", "name": "USP21 deubiquitinates RIPK1,DDX58", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10610835" ], "products": [ "species_10609754", "species_10610839" ], "modifiers": [ [ "species_10610835", "catalyst" ] ], "additional_components": [ "Q54XX5", "DDB_G0278535", "Q86L44", "DDB_G0294407", "Q55EJ1", "DDB_G0268872", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54XX5", "DDB_G0278535", "Q86L44", "DDB_G0294407", "Q55EJ1", "DDB_G0268872", "Q54XX5", "DDB_G0278535", "Q86L44", "DDB_G0294407", "Q55EJ1", "DDB_G0268872" ] }, "reaction_10612029": { "compartment": "compartment_7660", "id": "reaction_10612029", "reactome": "R-DDI-5696605", "name": "USP12, USP26 deubiquitinate AR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10612022" ], "products": [ "species_10612026", "species_10610745" ], "modifiers": [ [ "species_10612022", "catalyst" ] ], "additional_components": [ "Q54ZP5", "DDB_G0277533", "Q54G37", "DDB_G0290453", "Q54UB2", "DDB_G0281319", "Q54ZP5", "DDB_G0277533", "Q54G37", "DDB_G0290453", "Q54UB2", "DDB_G0281319", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54ZP5", "DDB_G0277533", "Q54G37", "DDB_G0290453", "Q54UB2", "DDB_G0281319" ] }, "reaction_10610748": { "compartment": "compartment_7660", "id": "reaction_10610748", "reactome": "R-DDI-5689950", "name": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10609773" ], "products": [ "species_10610745", "species_10609777" ], "modifiers": [ [ "species_10609773", "catalyst" ] ], "additional_components": [ "Q8T9S7", "DDB_G0286557", "Q869U4", "DDB_G0276443", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q869U4", "DDB_G0276443", "Q8T9S7", "DDB_G0286557", "Q8T9S7", "DDB_G0286557", "Q869U4", "DDB_G0276443" ] }, "reaction_10595007": { "compartment": "compartment_70101", "id": "reaction_10595007", "reactome": "R-DDI-936390", "name": "CYLD mediated deubiquitination of DDX58 (RIG-I)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10595000" ], "products": [ "species_10577037", "species_10595002" ], "modifiers": [ [ "species_10595004", "catalyst" ] ], "additional_components": [ "DDB_G0294407", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0294407", "DDB_G0277345" ] }, "reaction_10609757": { "compartment": "compartment_70101", "id": "reaction_10609757", "reactome": "R-DDI-5689111", "name": "PARK2 autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609754", "species_10596322" ], "products": [ "species_10608777" ], "modifiers": [ [ "species_10596322", "catalyst" ] ], "additional_components": [ "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54I29", "DDB_G0289043", "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043" ] }, "reaction_10608751": { "compartment": "compartment_70101", "id": "reaction_10608751", "reactome": "R-DDI-5688797", "name": "ATXN3 family cleave Ub chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10584754" ], "products": [ "species_10584754", "species_10584752" ], "modifiers": [ [ "species_10608748", "catalyst" ] ], "additional_components": [ "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q55DI9", "DDB_G0269646" ] }, "reaction_10590032": { "compartment": "compartment_12045", "id": "reaction_10590032", "reactome": "R-DDI-381109", "name": "IRE1 binds IRE1 forming dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590020" ], "products": [ "species_10590022" ], "modifiers": [], "additional_components": [ "DDB_G0267650", "Q55GJ2", "DDB_G0267650" ] }, "reaction_10590030": { "compartment": "compartment_12045", "id": "reaction_10590030", "reactome": "R-DDI-381091", "name": "IRE1 dimer autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10590022" ], "products": [ "species_10590027", "species_29370" ], "modifiers": [ [ "species_10590022", "catalyst" ] ], "additional_components": [ "Q55GJ2", "DDB_G0267650", "Q55GJ2", "DDB_G0267650", "Q55GJ2", "DDB_G0267650" ] }, "reaction_10590082": { "compartment": "compartment_12045", "id": "reaction_10590082", "reactome": "R-DDI-381186", "name": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590078" ], "products": [ "species_10590052" ], "modifiers": [], "additional_components": [ "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023" ] }, "reaction_10590886": { "compartment": "compartment_20699", "id": "reaction_10590886", "reactome": "R-DDI-420818", "name": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590058" ], "products": [ "species_10590878", "species_10589991" ], "modifiers": [ [ "species_10590883", "catalyst" ] ], "additional_components": [ "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "DDB_G0275939" ] }, "reaction_10590072": { "compartment": "compartment_20699", "id": "reaction_10590072", "reactome": "R-DDI-381135", "name": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590052" ], "products": [ "species_10590058", "species_10590064" ], "modifiers": [ [ "species_10590069", "catalyst" ] ], "additional_components": [ "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023", "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "DDB_G0282397" ] }, "reaction_10589999": { "compartment": "compartment_70101", "id": "reaction_10589999", "reactome": "R-DDI-381026", "name": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589991" ], "products": [ "species_10589997" ], "modifiers": [], "additional_components": [ "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439" ] }, "reaction_10590040": { "compartment": "compartment_70101", "id": "reaction_10590040", "reactome": "R-DDI-381111", "name": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10580002" ], "products": [ "species_29370", "species_10590037" ], "modifiers": [ [ "species_10590013", "catalyst" ] ], "additional_components": [ "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "Q54R98", "DDB_G0283301" ] }, "reaction_10590015": { "compartment": "compartment_12045", "id": "reaction_10590015", "reactome": "R-DDI-381087", "name": "Dimerization of PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590004" ], "products": [ "species_10590013" ], "modifiers": [], "additional_components": [ "DDB_G0283301", "Q54R98", "DDB_G0283301" ] }, "reaction_10577620": { "compartment": "compartment_7660", "id": "reaction_10577620", "reactome": "R-DDI-69608", "name": "Phosphorylation of Cdc25A at Ser-123 by Chk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10577539" ], "products": [ "species_10577598", "species_113582" ], "modifiers": [ [ "species_10577617", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "DDB_G0280321" ] }, "reaction_10577608": { "compartment": "compartment_7660", "id": "reaction_10577608", "reactome": "R-DDI-69604", "name": "Phosphorylation of Cdc25A at Ser-123 by Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10577539" ], "products": [ "species_10577598", "species_113582" ], "modifiers": [ [ "species_10577605", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "DDB_G0279719" ] }, "reaction_10577596": { "compartment": "compartment_70101", "id": "reaction_10577596", "reactome": "R-DDI-69600", "name": "Proteolytic degradation of ubiquitinated-Cdc25A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577594" ], "products": [ "species_10577037" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q54QM6", "DDB_G0283617", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10626291": { "compartment": "compartment_161320", "id": "reaction_10626291", "reactome": "R-DDI-9638076", "name": "HEXB cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162223", "species_1605715" ], "products": [ "species_1678743", "species_2162224" ], "modifiers": [ [ "species_10598378", "catalyst" ] ], "additional_components": [ "P13723", "DDB_G0287033" ] }, "reaction_10600527": { "compartment": "compartment_161320", "id": "reaction_10600527", "reactome": "R-DDI-2162225", "name": "HEXA cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162223", "species_1605715" ], "products": [ "species_1678743", "species_2162224" ], "modifiers": [ [ "species_10598376", "catalyst" ] ], "additional_components": [ "Q54K55", "DDB_G0287597", "Q54SC9", "DDB_G0282539", "Q54K56", "DDB_G0287659", "Q54MU9", "DDB_G0285647", "P13723", "DDB_G0287033" ] }, "reaction_10612384": { "compartment": "compartment_7660", "id": "reaction_10612384", "reactome": "R-DDI-6782069", "name": "UVSSA:USP7 deubiquitinates ERCC6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10612375" ], "products": [ "species_10612381", "species_10576865" ], "modifiers": [ [ "species_10612375", "catalyst" ] ], "additional_components": [ "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54TY2", "DDB_G0281441", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54TY2", "DDB_G0281441", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54TY2", "DDB_G0281441", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10612308": { "compartment": "compartment_7660", "id": "reaction_10612308", "reactome": "R-DDI-6781824", "name": "Active RNA Pol II complex transcribes lesion-containing DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612301", "species_6781829" ], "products": [ "species_113541", "species_10612305" ], "modifiers": [ [ "species_10612301", "catalyst" ] ], "additional_components": [ "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729" ] }, "reaction_10612328": { "compartment": "compartment_7660", "id": "reaction_10612328", "reactome": "R-DDI-6781833", "name": "ERCC8 (CSA) binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612315", "species_10612324" ], "products": [ "species_10611193", "species_10612326" ], "modifiers": [], "additional_components": [ "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54TY2", "DDB_G0281441", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54PF3", "DDB_G0284597", "Q54QX3", "DDB_G0283587", "Q54HL6", "DDB_G0289361", "Q55BD5", "DDB_G0271282", "Q54E53", "DDB_G0291848", "Q54C92", "DDB_G0293180", "Q75K24", "DDB_G0275471", "Q54B82", "DDB_G0293844", "Q54PF3", "DDB_G0284597", "Q54QX3", "DDB_G0283587", "Q54HL6", "DDB_G0289361", "Q55BD5", "DDB_G0271282", "Q54E53", "DDB_G0291848", "Q54C92", "DDB_G0293180", "Q75K24", "DDB_G0275471", "Q54B82", "DDB_G0293844", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54TY2", "DDB_G0281441" ] }, "reaction_10612330": { "compartment": "compartment_7660", "id": "reaction_10612330", "reactome": "R-DDI-6781840", "name": "ERCC6 binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612313", "species_10612305" ], "products": [ "species_10612315" ], "modifiers": [], "additional_components": [ "DDB_G0281441", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54TY2", "DDB_G0281441" ] }, "reaction_10612349": { "compartment": "compartment_7660", "id": "reaction_10612349", "reactome": "R-DDI-6781867", "name": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612326", "species_10576865" ], "products": [ "species_10612346" ], "modifiers": [ [ "species_10612326", "catalyst" ] ], "additional_components": [ "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54TY2", "DDB_G0281441", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54TY2", "DDB_G0281441", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54TY2", "DDB_G0281441" ] }, "reaction_10612303": { "compartment": "compartment_7660", "id": "reaction_10612303", "reactome": "R-DDI-6781818", "name": "RNA Pol II initiates transcription from damaged DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580699", "species_10578887", "species_5688114" ], "products": [ "species_10612301" ], "modifiers": [], "additional_components": [ "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729" ] }, "reaction_10590490": { "compartment": "compartment_70101", "id": "reaction_10590490", "reactome": "R-DDI-390329", "name": "Dephosphorylation of AKT by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10586959", "species_29356" ], "products": [ "species_29372", "species_10590487" ], "modifiers": [ [ "species_10590274", "catalyst" ] ], "additional_components": [ "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795" ] }, "reaction_10624161": { "compartment": "compartment_984", "id": "reaction_10624161", "reactome": "R-DDI-8979996", "name": "LIPs hydrolyze TG to DAG and LCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10624158", "catalyst" ] ], "additional_components": [] }, "reaction_10591551": { "compartment": "compartment_876", "id": "reaction_10591551", "reactome": "R-DDI-427998", "name": "Proton-coupled di- and tri-peptide cotransport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_428037" ], "products": [ "species_428026", "species_70106" ], "modifiers": [ [ "species_10591548", "catalyst" ] ], "additional_components": [ "CHEBI:90799", "CHEBI:47923", "CHEBI:47923", "CHEBI:90799", "DDB_G0267874" ] }, "reaction_10581636": { "compartment": "compartment_7660", "id": "reaction_10581636", "reactome": "R-DDI-75861", "name": "NTP Binds Active Site of RNA Polymerase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581630", "species_30595" ], "products": [ "species_10581634" ], "modifiers": [], "additional_components": [ "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "species_110614", "species_113592", "species_29494", "species_29438", "species_110614", "species_113592", "species_29494", "species_29438", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617" ] }, "reaction_10581644": { "compartment": "compartment_7660", "id": "reaction_10581644", "reactome": "R-DDI-75864", "name": "Newly Formed Phosphodiester Bond Stabilized and PPi Released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581642" ], "products": [ "species_10580924", "species_113541" ], "modifiers": [], "additional_components": [ "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617" ] }, "reaction_10581646": { "compartment": "compartment_7660", "id": "reaction_10581646", "reactome": "R-DDI-75866", "name": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581634" ], "products": [ "species_10581642" ], "modifiers": [], "additional_components": [ "species_110614", "species_113592", "species_29494", "species_29438", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617" ] }, "reaction_10581767": { "compartment": "compartment_7660", "id": "reaction_10581767", "reactome": "R-DDI-75949", "name": "RNA Polymerase II Promoter Opening: First Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10581638" ], "products": [ "species_113550", "species_113582", "species_10581630" ], "modifiers": [ [ "species_10580699", "catalyst" ] ], "additional_components": [ "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54FD6", "DDB_G0290929", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729" ] }, "reaction_10581650": { "compartment": "compartment_7660", "id": "reaction_10581650", "reactome": "R-DDI-75869", "name": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581608", "species_30595" ], "products": [ "species_10580844", "species_113541", "species_10581648" ], "modifiers": [ [ "species_10578889", "catalyst" ] ], "additional_components": [ "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "species_110614", "species_113592", "species_29494", "species_29438", "DDB_G0290929", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10626119": { "compartment": "compartment_7660", "id": "reaction_10626119", "reactome": "R-DDI-9613494", "name": "Unwinding of DNA for the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10581608" ], "products": [ "species_164121", "species_10581608", "species_113541" ], "modifiers": [ [ "species_10580699", "catalyst" ] ], "additional_components": [ "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729" ] }, "reaction_10581611": { "compartment": "compartment_7660", "id": "reaction_10581611", "reactome": "R-DDI-75850", "name": "Addition of the third nucleotide on the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580924", "species_30595" ], "products": [ "species_10581608", "species_113541" ], "modifiers": [ [ "species_10578889", "catalyst" ] ], "additional_components": [ "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "species_110614", "species_113592", "species_29494", "species_29438", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10626121": { "compartment": "compartment_7660", "id": "reaction_10626121", "reactome": "R-DDI-9613497", "name": "Unwinding DNA for the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580924", "species_30595" ], "products": [ "species_10580924", "species_113541" ], "modifiers": [ [ "species_10580699", "catalyst" ] ], "additional_components": [ "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "species_110614", "species_113592", "species_29494", "species_29438", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729" ] }, "reaction_10582826": { "compartment": "compartment_7660", "id": "reaction_10582826", "reactome": "R-DDI-111264", "name": "Addition of nucleotides between position +11 and +30", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582331", "species_30595" ], "products": [ "species_113541", "species_10582368" ], "modifiers": [ [ "species_10578889", "catalyst" ] ], "additional_components": [ "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "species_110614", "species_113592", "species_29494", "species_29438", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10582333": { "compartment": "compartment_7660", "id": "reaction_10582333", "reactome": "R-DDI-76576", "name": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581677", "species_30595" ], "products": [ "species_10582331", "species_113541" ], "modifiers": [ [ "species_10578889", "catalyst" ] ], "additional_components": [ "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "species_110614", "species_113592", "species_29494", "species_29438", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10581679": { "compartment": "compartment_7660", "id": "reaction_10581679", "reactome": "R-DDI-75873", "name": "Addition of Nucleotides 5 through 9 on the growing Transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10581648" ], "products": [ "species_10580910", "species_10581677", "species_10580922", "species_10580839", "species_113541" ], "modifiers": [ [ "species_10578889", "catalyst" ] ], "additional_components": [ "species_110614", "species_113592", "species_29494", "species_29438", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10590450": { "compartment": "compartment_17951", "id": "reaction_10590450", "reactome": "R-DDI-389986", "name": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_389894" ], "products": [ "species_389982" ], "modifiers": [ [ "species_10586623", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10590437": { "compartment": "compartment_17951", "id": "reaction_10590437", "reactome": "R-DDI-389889", "name": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389893" ], "products": [ "species_113575", "species_389894" ], "modifiers": [ [ "species_10590434", "catalyst" ] ], "additional_components": [ "species_113596", "Q54LF1", "DDB_G0286669", "Q54GQ6", "DDB_G0289993" ] }, "reaction_10590452": { "compartment": "compartment_17951", "id": "reaction_10590452", "reactome": "R-DDI-389995", "name": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389982", "species_192307" ], "products": [ "species_193465", "species_389996", "species_192305" ], "modifiers": [ [ "species_10586623", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10590447": { "compartment": "compartment_17951", "id": "reaction_10590447", "reactome": "R-DDI-389891", "name": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389893" ], "products": [ "species_113575", "species_389894" ], "modifiers": [ [ "species_10590444", "catalyst" ] ], "additional_components": [ "species_113596", "Q8MMS1", "DDB_G0277477" ] }, "reaction_10619972": { "compartment": "compartment_7660", "id": "reaction_10619972", "reactome": "R-DDI-8866601", "name": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_8866574" ], "products": [ "species_8866608", "species_8866567" ], "modifiers": [ [ "species_10619969", "catalyst" ], [ "species_29892", "catalyst" ] ], "additional_components": [ "B0G107", "DDB_G0272484", "species_29426" ] }, "reaction_10601235": { "compartment": "compartment_70101", "id": "reaction_10601235", "reactome": "R-DDI-2509827", "name": "ITPA hydrolyses ITP to IMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2509836" ], "products": [ "species_111294", "species_29602" ], "modifiers": [ [ "species_10601232", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54LQ6", "DDB_G0286495" ] }, "reaction_10581202": { "compartment": "compartment_70101", "id": "reaction_10581202", "reactome": "R-DDI-74247", "name": "Hypoxanthine + H2O + O2 => Xanthine + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113599", "species_29356", "species_29368" ], "products": [ "species_29408", "species_30064" ], "modifiers": [ [ "species_10581199", "catalyst" ] ], "additional_components": [ "CHEBI:44074", "species_113596", "Q54FB7", "DDB_G0291047" ] }, "reaction_10581222": { "compartment": "compartment_70101", "id": "reaction_10581222", "reactome": "R-DDI-74255", "name": "Guanine + H2O => Xanthine + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_83956" ], "products": [ "species_31633", "species_30064" ], "modifiers": [ [ "species_10581219", "catalyst" ] ], "additional_components": [ "Q86AW9", "DDB_G0277743", "species_29426" ] }, "reaction_10601238": { "compartment": "compartment_70101", "id": "reaction_10601238", "reactome": "R-DDI-2509831", "name": "ITPA hydrolyses XTP to XMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509848", "species_29356" ], "products": [ "species_111294", "species_111584" ], "modifiers": [ [ "species_10601232", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54LQ6", "DDB_G0286495" ] }, "reaction_10601241": { "compartment": "compartment_70101", "id": "reaction_10601241", "reactome": "R-DDI-2509838", "name": "ITPA hydrolyses dITP to dIMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509835", "species_29356" ], "products": [ "species_111294", "species_109330" ], "modifiers": [ [ "species_10601232", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54LQ6", "DDB_G0286495" ] }, "reaction_10581224": { "compartment": "compartment_70101", "id": "reaction_10581224", "reactome": "R-DDI-74258", "name": "Xanthine + H2O + O2 => Urate + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29368", "species_30064" ], "products": [ "species_30034", "species_29408" ], "modifiers": [ [ "species_10581199", "catalyst" ] ], "additional_components": [ "CHEBI:44074", "species_113596", "Q54FB7", "DDB_G0291047" ] }, "reaction_10581212": { "compartment": "compartment_70101", "id": "reaction_10581212", "reactome": "R-DDI-74248", "name": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500120", "species_29356" ], "products": [ "species_29372", "species_500118" ], "modifiers": [ [ "species_10581209", "catalyst" ] ], "additional_components": [ "species_29602", "species_109330", "species_113578", "CHEBI:16192", "CHEBI:17172", "CHEBI:28997", "species_83921", "CHEBI:16750", "Q54XC1", "DDB_G0279053", "species_29926" ] }, "reaction_10612835": { "compartment": "compartment_7660", "id": "reaction_10612835", "reactome": "R-DDI-6788810", "name": "AK6 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_6788813" ], "products": [ "species_113582", "species_6788807" ], "modifiers": [ [ "species_10612832", "catalyst" ] ], "additional_components": [ "CHEBI:15918", "species_109395", "species_76577", "species_109386", "species_110094", "CHEBI:16174", "CHEBI:28846", "species_29370", "DDB_G0278493" ] }, "reaction_10582661": { "compartment": "compartment_70101", "id": "reaction_10582661", "reactome": "R-DDI-110137", "name": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_6788782" ], "products": [ "species_6788778", "species_113592" ], "modifiers": [ [ "species_10582658", "catalyst" ] ], "additional_components": [ "species_29370", "CHEBI:28846", "CHEBI:16174", "species_110094", "species_76577", "species_109395", "CHEBI:15918", "species_109386", "Q54CT8", "DDB_G0292730", "Q54QJ9", "DDB_G0283805" ] }, "reaction_10582663": { "compartment": "compartment_70101", "id": "reaction_10582663", "reactome": "R-DDI-110138", "name": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788778", "species_113592" ], "products": [ "species_29370", "species_6788782" ], "modifiers": [ [ "species_10582658", "catalyst" ] ], "additional_components": [ "species_76577", "species_109395", "CHEBI:15918", "species_109386", "species_29370", "CHEBI:28846", "CHEBI:16174", "species_110094", "Q54CT8", "DDB_G0292730", "Q54QJ9", "DDB_G0283805" ] }, "reaction_10580715": { "compartment": "compartment_70101", "id": "reaction_10580715", "reactome": "R-DDI-73788", "name": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500071" ], "products": [ "species_29370", "species_500077" ], "modifiers": [ [ "species_10580712", "catalyst" ] ], "additional_components": [ "species_113578", "CHEBI:16192", "species_29420", "CHEBI:28862", "DDB_G0279001" ] }, "reaction_10580555": { "compartment": "compartment_70101", "id": "reaction_10580555", "reactome": "R-DDI-73635", "name": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_499997", "species_113592" ], "products": [ "species_29370", "species_499999" ], "modifiers": [ [ "species_10580552", "catalyst" ] ], "additional_components": [ "species_500742", "species_109366", "CHEBI:28850", "CHEBI:18075", "Q54GN2", "DDB_G0290033" ] }, "reaction_10593837": { "compartment": "compartment_5460", "id": "reaction_10593837", "reactome": "R-DDI-482804", "name": "(d)NDP + ATP <=> (d)NTP + ADP (NME4)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_482803" ], "products": [ "species_113581", "species_482807" ], "modifiers": [ [ "species_10593834", "catalyst" ] ], "additional_components": [ "CHEBI:18075", "species_29420", "CHEBI:28850", "CHEBI:28862", "species_110096", "CHEBI:16174", "CHEBI:28846", "species_110094", "species_110614", "species_29438", "species_500739", "species_29892", "species_29494", "species_29604", "species_30185", "species_30187", "P34093", "DDB_G0279911" ] }, "reaction_10582668": { "compartment": "compartment_70101", "id": "reaction_10582668", "reactome": "R-DDI-110144", "name": "ADP + ADP <=> AMP + ATP [AK2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370" ], "products": [ "species_113592", "species_76577" ], "modifiers": [ [ "species_10582665", "catalyst" ] ], "additional_components": [ "DDB_G0283805" ] }, "reaction_10616659": { "compartment": "compartment_70101", "id": "reaction_10616659", "reactome": "R-DDI-6806877", "name": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6806885" ], "products": [ "species_29370", "species_6806881" ], "modifiers": [ [ "species_10616656", "catalyst" ] ], "additional_components": [ "P34093", "DDB_G0279911" ] }, "reaction_10580565": { "compartment": "compartment_70101", "id": "reaction_10580565", "reactome": "R-DDI-73647", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_29494", "species_29472" ], "products": [ "species_29372", "species_29404", "species_29370", "species_110614" ], "modifiers": [ [ "species_10580562", "catalyst" ] ], "additional_components": [ "Q54V77", "DDB_G0280567" ] }, "reaction_10580407": { "compartment": "compartment_70101", "id": "reaction_10580407", "reactome": "R-DDI-73548", "name": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500009", "species_113592" ], "products": [ "species_29370", "species_500006" ], "modifiers": [ [ "species_10580404", "catalyst" ] ], "additional_components": [ "species_109395", "CHEBI:15918", "species_109402", "species_110096", "CHEBI:28846", "species_110094", "DDB_G0287495" ] }, "reaction_10593654": { "compartment": "compartment_70101", "id": "reaction_10593654", "reactome": "R-DDI-482619", "name": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_482627" ], "products": [ "species_29370", "species_482625" ], "modifiers": [ [ "species_10593651", "catalyst" ] ], "additional_components": [ "species_110096", "CHEBI:28846", "CHEBI:16174", "species_29420", "CHEBI:28850", "CHEBI:28862", "CHEBI:18075", "species_110094", "species_29892", "species_29604", "species_30185", "species_29494", "species_30187", "species_110614", "species_500739", "species_29438", "P34093", "DDB_G0279911" ] }, "reaction_10612827": { "compartment": "compartment_5460", "id": "reaction_10612827", "reactome": "R-DDI-6788798", "name": "AK4 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_6788802" ], "products": [ "species_113581", "species_6788801" ], "modifiers": [ [ "species_10612824", "catalyst" ] ], "additional_components": [ "species_109395", "species_109386", "species_76577", "CHEBI:15918", "species_29370", "CHEBI:16174", "CHEBI:28846", "species_110094", "DDB_G0292730" ] }, "reaction_10593851": { "compartment": "compartment_70101", "id": "reaction_10593851", "reactome": "R-DDI-504054", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_29494", "species_29472" ], "products": [ "species_29372", "species_29404", "species_29370", "species_110614" ], "modifiers": [ [ "species_10593848", "catalyst" ] ], "additional_components": [ "Q54V77", "DDB_G0280567" ] }, "reaction_10580575": { "compartment": "compartment_7660", "id": "reaction_10580575", "reactome": "R-DDI-73666", "name": "dUTP + H2O => dUMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_500739" ], "products": [ "species_113541", "species_500742" ], "modifiers": [ [ "species_10580572", "catalyst" ] ], "additional_components": [ "Q54BW5", "DDB_G0293374" ] }, "reaction_10580545": { "compartment": "compartment_70101", "id": "reaction_10580545", "reactome": "R-DDI-73632", "name": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_83928" ], "products": [ "species_29370", "species_109366" ], "modifiers": [ [ "species_10580542", "catalyst" ] ], "additional_components": [ "Q27564", "DDB_G0289179" ] }, "reaction_10580529": { "compartment": "compartment_70101", "id": "reaction_10580529", "reactome": "R-DDI-73608", "name": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500829" ], "products": [ "species_500430", "species_31633" ], "modifiers": [ [ "species_10580526", "catalyst" ] ], "additional_components": [ "CHEBI:15698", "CHEBI:17562", "CHEBI:16450", "CHEBI:16704", "species_29426", "Q54I82", "DDB_G0288933" ] }, "reaction_10623936": { "compartment": "compartment_70101", "id": "reaction_10623936", "reactome": "R-DDI-8954327", "name": "UCKL1 phosphorylates urindine, cytidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500759" ], "products": [ "species_500761", "species_29370" ], "modifiers": [ [ "species_10623933", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:17562", "species_109395", "species_109402", "DDB_G0274559" ] }, "reaction_10582628": { "compartment": "compartment_70101", "id": "reaction_10582628", "reactome": "R-DDI-109903", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500759" ], "products": [ "species_500761", "species_29370" ], "modifiers": [ [ "species_10582625", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:17562", "species_109395", "species_109402", "Q55EL3", "DDB_G0269034", "Q8T154", "DDB_G0274559" ] }, "reaction_10580519": { "compartment": "compartment_70101", "id": "reaction_10580519", "reactome": "R-DDI-73599", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500759" ], "products": [ "species_500761", "species_29370" ], "modifiers": [ [ "species_10580516", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:17562", "species_109395", "species_109402", "Q8T154", "DDB_G0274559", "Q55EL3", "DDB_G0269034" ] }, "reaction_10581238": { "compartment": "compartment_70101", "id": "reaction_10581238", "reactome": "R-DDI-74372", "name": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83962", "species_500244" ], "products": [ "species_29372", "species_500430" ], "modifiers": [ [ "species_10581235", "catalyst" ] ], "additional_components": [ "CHEBI:28542", "species_112016", "CHEBI:16450", "CHEBI:16704", "Q54PM8", "DDB_G0284431" ] }, "reaction_10580502": { "compartment": "compartment_70101", "id": "reaction_10580502", "reactome": "R-DDI-73598", "name": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500829", "species_113592" ], "products": [ "species_500828", "species_29370" ], "modifiers": [ [ "species_10580499", "catalyst" ] ], "additional_components": [ "CHEBI:15698", "CHEBI:17562", "species_109395", "CHEBI:15918", "Q54YL2", "DDB_G0278191", "species_29926" ] }, "reaction_10582606": { "compartment": "compartment_5460", "id": "reaction_10582606", "reactome": "R-DDI-109759", "name": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_500822" ], "products": [ "species_113581", "species_500823" ], "modifiers": [ [ "species_10582603", "catalyst" ] ], "additional_components": [ "species_83928", "CHEBI:16450", "CHEBI:15698", "species_109366", "species_500742", "CHEBI:15918", "DDB_G0278191" ] }, "reaction_10582353": { "compartment": "compartment_70101", "id": "reaction_10582353", "reactome": "R-DDI-76590", "name": "AMP + H2O => IMP + NH4+ (AMPD)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_76577" ], "products": [ "species_29602", "species_31633" ], "modifiers": [ [ "species_10582350", "catalyst" ] ], "additional_components": [ "Q54DD0", "DDB_G0292266" ] }, "reaction_10581184": { "compartment": "compartment_5460", "id": "reaction_10581184", "reactome": "R-DDI-74207", "name": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_500224" ], "products": [ "species_113581", "species_500222" ], "modifiers": [ [ "species_10581181", "catalyst" ] ], "additional_components": [ "CHEBI:17172", "CHEBI:17256", "CHEBI:28997", "CHEBI:16192", "species_109386", "species_109330", "Q54YL2", "DDB_G0278191" ] }, "reaction_10582544": { "compartment": "compartment_70101", "id": "reaction_10582544", "reactome": "R-DDI-109624", "name": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500173", "species_113592" ], "products": [ "species_500088", "species_29370" ], "modifiers": [ [ "species_10582541", "catalyst" ] ], "additional_components": [ "species_83909", "CHEBI:17256", "species_76577", "species_109386", "species_29926", "Q54MB5", "DDB_G0286057" ] }, "reaction_10581192": { "compartment": "compartment_70101", "id": "reaction_10581192", "reactome": "R-DDI-74241", "name": "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH4+ (ADA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500173" ], "products": [ "species_500172", "species_31633" ], "modifiers": [ [ "species_10581189", "catalyst" ] ], "additional_components": [ "species_83909", "CHEBI:17256", "CHEBI:28997", "species_83921", "DDB_G0287371" ] }, "reaction_10582554": { "compartment": "compartment_70101", "id": "reaction_10582554", "reactome": "R-DDI-109671", "name": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500201", "species_113592" ], "products": [ "species_29370", "species_500199" ], "modifiers": [ [ "species_10580499", "catalyst" ] ], "additional_components": [ "CHEBI:17172", "CHEBI:17256", "species_109386", "CHEBI:16192", "Q54YL2", "DDB_G0278191", "species_29926" ] }, "reaction_10580768": { "compartment": "compartment_70101", "id": "reaction_10580768", "reactome": "R-DDI-73813", "name": "GAR + 10-Formyl-THF => FGAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111338", "species_419151" ], "products": [ "species_111354", "species_111355" ], "modifiers": [ [ "species_10580754", "catalyst" ] ], "additional_components": [ "DDB_G0290121" ] }, "reaction_10580771": { "compartment": "compartment_70101", "id": "reaction_10580771", "reactome": "R-DDI-73814", "name": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111292", "species_113592", "species_29424" ], "products": [ "species_29372", "species_111338", "species_29370" ], "modifiers": [ [ "species_10580754", "catalyst" ] ], "additional_components": [ "DDB_G0290121" ] }, "reaction_10580723": { "compartment": "compartment_70101", "id": "reaction_10580723", "reactome": "R-DDI-73792", "name": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_111584", "species_29472" ], "products": [ "species_111294", "species_29404", "species_113578", "species_76577" ], "modifiers": [ [ "species_10580720", "catalyst" ] ], "additional_components": [ "DDB_G0281551" ] }, "reaction_10580757": { "compartment": "compartment_70101", "id": "reaction_10580757", "reactome": "R-DDI-73810", "name": "FGAM + ATP => AIR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111369" ], "products": [ "species_29372", "species_111370", "species_29370" ], "modifiers": [ [ "species_10580754", "catalyst" ] ], "additional_components": [ "DDB_G0290121" ] }, "reaction_10582854": { "compartment": "compartment_70101", "id": "reaction_10582854", "reactome": "R-DDI-111524", "name": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29448", "species_29602" ], "products": [ "species_29372", "species_29420", "species_35141" ], "modifiers": [ [ "species_10582851", "catalyst" ], [ "species_113578", "inhibitor" ], [ "species_29420", "inhibitor" ], [ "species_30014", "inhibitor" ], [ "species_35141", "inhibitor" ] ], "additional_components": [ "species_29926", "P21900", "DDB_G0285429" ] }, "reaction_10627338": { "compartment": "compartment_70101", "id": "reaction_10627338", "reactome": "R-DDI-9678749", "name": "IMPDH tetramers binds IMPDH inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9678719", "species_10580730" ], "products": [ "species_10580733" ], "modifiers": [], "additional_components": [ "Q54QQ0", "DDB_G0283701", "Q54QQ0", "DDB_G0283701" ] }, "reaction_10580746": { "compartment": "compartment_70101", "id": "reaction_10580746", "reactome": "R-DDI-73797", "name": "FAICAR => IMP + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111427" ], "products": [ "species_29356", "species_29602" ], "modifiers": [ [ "species_10580743", "catalyst" ] ], "additional_components": [ "Q86L14", "DDB_G0277087" ] }, "reaction_10580765": { "compartment": "compartment_70101", "id": "reaction_10580765", "reactome": "R-DDI-73812", "name": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111354", "species_113592", "species_29472" ], "products": [ "species_29372", "species_29404", "species_29370", "species_111369" ], "modifiers": [ [ "species_10580762", "catalyst" ] ], "additional_components": [ "DDB_G0288145" ] }, "reaction_10580749": { "compartment": "compartment_70101", "id": "reaction_10580749", "reactome": "R-DDI-73798", "name": "AICAR + 10-Formyl-THF => FAICAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_419151", "species_111409" ], "products": [ "species_111355", "species_111427" ], "modifiers": [ [ "species_10580743", "catalyst" ] ], "additional_components": [ "Q86L14", "DDB_G0277087" ] }, "reaction_10580735": { "compartment": "compartment_70101", "id": "reaction_10580735", "reactome": "R-DDI-73794", "name": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29602", "species_29360" ], "products": [ "species_70106", "species_111584", "species_73473" ], "modifiers": [ [ "species_10580730", "catalyst" ], [ "species_111584", "inhibitor" ], [ "species_10580733", "inhibitor" ] ], "additional_components": [ "Q54QQ0", "DDB_G0283701", "Q54QQ0", "DDB_G0283701" ] }, "reaction_10580433": { "compartment": "compartment_70101", "id": "reaction_10580433", "reactome": "R-DDI-73573", "name": "CAD hexamer transforms CAP to N-carb-L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111647", "species_29448" ], "products": [ "species_111628", "species_29372" ], "modifiers": [ [ "species_10580427", "catalyst" ] ], "additional_components": [ "P20054", "DDB_G0276335" ] }, "reaction_10580417": { "compartment": "compartment_70101", "id": "reaction_10580417", "reactome": "R-DDI-73564", "name": "UMPS dimer decarboxylates OMP to UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111629" ], "products": [ "species_109402", "species_113528" ], "modifiers": [ [ "species_10580414", "catalyst" ] ], "additional_components": [ "P09556", "DDB_G0280041" ] }, "reaction_10580436": { "compartment": "compartment_70101", "id": "reaction_10580436", "reactome": "R-DDI-73577", "name": "CAD hexamer transforms L-Gln to CAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111627", "species_113592", "species_29472" ], "products": [ "species_111647", "species_29372", "species_29404", "species_29370" ], "modifiers": [ [ "species_10580427", "catalyst" ] ], "additional_components": [ "P20054", "DDB_G0276335" ] }, "reaction_10580420": { "compartment": "compartment_70101", "id": "reaction_10580420", "reactome": "R-DDI-73567", "name": "UMPS dimer transfers phoshoribosyl group to ORO to form OMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_76632" ], "products": [ "species_111294", "species_111629" ], "modifiers": [ [ "species_10580414", "catalyst" ] ], "additional_components": [ "P09556", "DDB_G0280041" ] }, "reaction_10580430": { "compartment": "compartment_70101", "id": "reaction_10580430", "reactome": "R-DDI-73571", "name": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111628", "species_70106" ], "products": [ "species_29356", "species_76630" ], "modifiers": [ [ "species_10580427", "catalyst" ] ], "additional_components": [ "P20054", "DDB_G0276335" ] }, "reaction_10611880": { "compartment": "compartment_12045", "id": "reaction_10611880", "reactome": "R-DDI-5696021", "name": "ADPGK:Mg2+ phosphorylates Glc to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_70113" ], "products": [ "species_30537", "species_76577" ], "modifiers": [ [ "species_10611877", "catalyst" ] ], "additional_components": [ "species_29926", "Q54K22", "DDB_G0287631" ] }, "reaction_10578788": { "compartment": "compartment_70101", "id": "reaction_10578788", "reactome": "R-DDI-71802", "name": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29512" ], "products": [ "species_29370", "species_30533" ], "modifiers": [ [ "species_10578785", "catalyst" ], [ "species_30533", "catalyst" ] ], "additional_components": [ "Q54SI2", "DDB_G0282759", "Q551Y6", "DDB_G0282759" ] }, "reaction_10577647": { "compartment": "compartment_70101", "id": "reaction_10577647", "reactome": "R-DDI-70262", "name": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30533" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10577644", "catalyst" ] ], "additional_components": [ "Q54SI2", "DDB_G0282759", "Q551Y6", "DDB_G0282759" ] }, "reaction_10578671": { "compartment": "compartment_70101", "id": "reaction_10578671", "reactome": "R-DDI-71670", "name": "phosphoenolpyruvate + ADP => pyruvate + ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29370", "species_29492" ], "products": [ "species_113592", "species_29398" ], "modifiers": [ [ "species_10578668", "catalyst" ], [ "species_30014", "catalyst" ], [ "species_76183", "inhibitor" ], [ "species_29358", "inhibitor" ], [ "species_30389", "inhibitor" ] ], "additional_components": [ "Q54RF5", "DDB_G0283247", "species_29926", "species_74126" ] }, "reaction_10613720": { "compartment": "compartment_70101", "id": "reaction_10613720", "reactome": "R-DDI-6798335", "name": "BPGM dimer isomerises 1,3BPG to 2,3BPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29800" ], "products": [ "species_6798337" ], "modifiers": [ [ "species_10613717", "catalyst" ] ], "additional_components": [ "Q54NE6", "DDB_G0285311" ] }, "reaction_10616029": { "compartment": "compartment_70101", "id": "reaction_10616029", "reactome": "R-DDI-6799604", "name": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_449701" ], "products": [ "species_29512", "species_31633" ], "modifiers": [ [ "species_10616026", "catalyst" ] ], "additional_components": [ "Q54XK9", "DDB_G0278873" ] }, "reaction_10623996": { "compartment": "compartment_70101", "id": "reaction_10623996", "reactome": "R-DDI-8955760", "name": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30537", "species_29800" ], "products": [ "species_70106", "species_8955759", "species_29728" ], "modifiers": [ [ "species_10577658", "catalyst" ] ], "additional_components": [ "species_29926", "Q54UQ2", "DDB_G0280897" ] }, "reaction_10606595": { "compartment": "compartment_70101", "id": "reaction_10606595", "reactome": "R-DDI-5661256", "name": "AKR1A1 reduces D-glucuronate to L-gulonate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_5661264", "species_29364" ], "products": [ "species_29366", "species_5661268" ], "modifiers": [ [ "species_10606592", "catalyst" ] ], "additional_components": [ "DDB_G0293850" ] }, "reaction_10626289": { "compartment": "compartment_161320", "id": "reaction_10626289", "reactome": "R-DDI-9638075", "name": "HEXB cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065269" ], "products": [ "species_1605658", "species_2105025" ], "modifiers": [ [ "species_10598378", "catalyst" ] ], "additional_components": [ "P13723", "DDB_G0287033" ] }, "reaction_10600151": { "compartment": "compartment_161320", "id": "reaction_10600151", "reactome": "R-DDI-2105001", "name": "HEXA cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065269" ], "products": [ "species_1605658", "species_2105025" ], "modifiers": [ [ "species_10598376", "catalyst" ] ], "additional_components": [ "Q54K55", "DDB_G0287597", "Q54SC9", "DDB_G0282539", "Q54K56", "DDB_G0287659", "Q54MU9", "DDB_G0285647", "P13723", "DDB_G0287033" ] }, "reaction_10599228": { "compartment": "compartment_161320", "id": "reaction_10599228", "reactome": "R-DDI-1793186", "name": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2105025" ], "products": [ "species_2104993", "species_1678617" ], "modifiers": [ [ "species_10599145", "catalyst" ] ], "additional_components": [ "DDB_G0288289" ] }, "reaction_10594113": { "compartment": "compartment_20699", "id": "reaction_10594113", "reactome": "R-DDI-741449", "name": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471" ], "products": [ "species_741440" ], "modifiers": [ [ "species_10594110", "catalyst" ] ], "additional_components": [ "DDB_G0269602" ] }, "reaction_10591509": { "compartment": "compartment_876", "id": "reaction_10591509", "reactome": "R-DDI-427555", "name": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_427648" ], "products": [ "species_70106", "species_174375" ], "modifiers": [ [ "species_10591506", "catalyst" ] ], "additional_components": [ "B0G157", "DDB_G0286611", "Q55FK8", "DDB_G0286611" ] }, "reaction_10598500": { "compartment": "compartment_161320", "id": "reaction_10598500", "reactome": "R-DDI-1630306", "name": "GLB1 hydrolyses a glycosaminoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2104997" ], "products": [ "species_1605637", "species_2104995" ], "modifiers": [ [ "species_10598338", "catalyst" ] ], "additional_components": [ "DDB_G0290217" ] }, "reaction_10598503": { "compartment": "compartment_161320", "id": "reaction_10598503", "reactome": "R-DDI-1638053", "name": "HEXA cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2105012" ], "products": [ "species_2105010", "species_1605658" ], "modifiers": [ [ "species_10598376", "catalyst" ] ], "additional_components": [ "Q54K55", "DDB_G0287597", "Q54SC9", "DDB_G0282539", "Q54K56", "DDB_G0287659", "Q54MU9", "DDB_G0285647", "P13723", "DDB_G0287033" ] }, "reaction_10626293": { "compartment": "compartment_161320", "id": "reaction_10626293", "reactome": "R-DDI-9638078", "name": "HEXB cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2105012" ], "products": [ "species_2105010", "species_1605658" ], "modifiers": [ [ "species_10598378", "catalyst" ] ], "additional_components": [ "P13723", "DDB_G0287033" ] }, "reaction_10626002": { "compartment": "compartment_17963", "id": "reaction_10626002", "reactome": "R-DDI-9603984", "name": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9033790", "species_205683" ], "products": [ "species_9605593", "species_205689" ], "modifiers": [ [ "species_10625999", "catalyst" ] ], "additional_components": [ "Q54PK0", "DDB_G0284775", "Q54PJ9", "DDB_G0284775", "Q54RA6", "DDB_G0284775", "Q54PK3", "DDB_G0284551", "Q86J24", "DDB_G0284775", "Q54PH9", "DDB_G0284467", "Q54P60", "DDB_G0284775" ] }, "reaction_10626007": { "compartment": "compartment_17963", "id": "reaction_10626007", "reactome": "R-DDI-9605609", "name": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605595", "species_205683" ], "products": [ "species_9605615", "species_205689" ], "modifiers": [ [ "species_10611506", "catalyst" ] ], "additional_components": [ "Q54PK0", "DDB_G0284775", "Q86J24", "DDB_G0284775", "Q54P60", "DDB_G0284775", "Q54PH9", "DDB_G0284467", "Q54PK3", "DDB_G0284551", "Q54RA6", "DDB_G0284775", "Q54PJ9", "DDB_G0284775" ] }, "reaction_10626004": { "compartment": "compartment_17963", "id": "reaction_10626004", "reactome": "R-DDI-9603986", "name": "FUT3 transfers Fuc to Type 1 chains to form LeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9036984", "species_205683" ], "products": [ "species_205689", "species_9605607" ], "modifiers": [ [ "species_10611506", "catalyst" ] ], "additional_components": [ "Q54PK0", "DDB_G0284775", "Q86J24", "DDB_G0284775", "Q54P60", "DDB_G0284775", "Q54PH9", "DDB_G0284467", "Q54PK3", "DDB_G0284551", "Q54RA6", "DDB_G0284775", "Q54PJ9", "DDB_G0284775" ] }, "reaction_10626009": { "compartment": "compartment_17963", "id": "reaction_10626009", "reactome": "R-DDI-9605644", "name": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605649", "species_205683" ], "products": [ "species_205689", "species_9605651" ], "modifiers": [ [ "species_10611506", "catalyst" ] ], "additional_components": [ "Q54PK0", "DDB_G0284775", "Q86J24", "DDB_G0284775", "Q54P60", "DDB_G0284775", "Q54PH9", "DDB_G0284467", "Q54PK3", "DDB_G0284551", "Q54RA6", "DDB_G0284775", "Q54PJ9", "DDB_G0284775" ] }, "reaction_10626030": { "compartment": "compartment_17963", "id": "reaction_10626030", "reactome": "R-DDI-9605682", "name": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605685", "species_205683" ], "products": [ "species_9605661", "species_205689" ], "modifiers": [ [ "species_10626027", "catalyst" ] ], "additional_components": [ "Q54PK0", "DDB_G0284775", "Q86J24", "DDB_G0284775", "Q54P60", "DDB_G0284775", "Q54PH9", "DDB_G0284467", "Q54PK3", "DDB_G0284551", "Q54RA6", "DDB_G0284775", "Q54PJ9", "DDB_G0284775" ] }, "reaction_10606317": { "compartment": "compartment_17963", "id": "reaction_10606317", "reactome": "R-DDI-5653873", "name": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_964746" ], "modifiers": [ [ "species_10606314", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10577719": { "compartment": "compartment_70101", "id": "reaction_10577719", "reactome": "R-DDI-70427", "name": "PGM:Mg2+ isomerise G1P to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29548" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10577660", "catalyst" ] ], "additional_components": [ "Q54UQ2", "DDB_G0280897", "species_29926" ] }, "reaction_10615984": { "compartment": "compartment_70101", "id": "reaction_10615984", "reactome": "R-DDI-6799545", "name": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6799540" ], "products": [ "species_429579", "species_6799543" ], "modifiers": [ [ "species_10615981", "catalyst" ] ], "additional_components": [ "species_29426", "Q54K67", "DDB_G0287577" ] }, "reaction_10619249": { "compartment": "compartment_161320", "id": "reaction_10619249", "reactome": "R-DDI-8853710", "name": "MANBA hydrolyses GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8853719" ], "products": [ "species_1678743", "species_6799594" ], "modifiers": [ [ "species_10619246", "catalyst" ] ], "additional_components": [ "DDB_G0275917" ] }, "reaction_10616013": { "compartment": "compartment_161320", "id": "reaction_10616013", "reactome": "R-DDI-6799581", "name": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6799577", "species_1605715" ], "products": [ "species_6799594", "species_8853719" ], "modifiers": [ [ "species_10616010", "catalyst" ] ], "additional_components": [ "Q54YF7", "DDB_G0278259", "P34098", "DDB_G0292206", "Q1ZXI8", "DDB_G0278651", "Q55ER0", "DDB_G0268994", "Q54YC4", "DDB_G0278653", "species_29426" ] }, "reaction_10619244": { "compartment": "compartment_161320", "id": "reaction_10619244", "reactome": "R-DDI-8853686", "name": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_8853396" ], "products": [ "species_6799577", "species_6799594" ], "modifiers": [ [ "species_10619241", "catalyst" ] ], "additional_components": [ "P34098", "DDB_G0292206", "species_29426" ] }, "reaction_10593362": { "compartment": "compartment_70101", "id": "reaction_10593362", "reactome": "R-DDI-453339", "name": "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_10578646" ], "products": [ "species_29548", "species_10593360" ], "modifiers": [ [ "species_10578628", "catalyst" ] ], "additional_components": [ "Q54L24", "DDB_G0286945", "species_266099", "species_266099", "Q54L24", "DDB_G0286945", "Q00766", "DDB_G0281383" ] }, "reaction_10593364": { "compartment": "compartment_70101", "id": "reaction_10593364", "reactome": "R-DDI-453342", "name": "PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10578574", "species_76577" ], "products": [ "species_10593354" ], "modifiers": [ [ "species_113592", "inhibitor" ], [ "species_30537", "inhibitor" ] ], "additional_components": [ "P34114", "DDB_G0291123", "Q00766", "DDB_G0281383", "species_76577", "P34114", "DDB_G0291123", "Q00766", "DDB_G0281383" ] }, "reaction_10625828": { "compartment": "compartment_161320", "id": "reaction_10625828", "reactome": "R-DDI-9036727", "name": "GAA hydrolyzes lysosomal glycogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_10625815" ], "products": [ "species_1605745", "species_10625819" ], "modifiers": [ [ "species_10625825", "catalyst" ] ], "additional_components": [ "species_266099", "Q54L24", "DDB_G0286945", "species_266099", "Q54L24", "DDB_G0286945", "Q55D50", "DDB_G0269790" ] }, "reaction_10578619": { "compartment": "compartment_70101", "id": "reaction_10578619", "reactome": "R-DDI-71552", "name": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10578599" ], "products": [ "species_10578611" ], "modifiers": [ [ "species_10578616", "catalyst" ] ], "additional_components": [ "species_266099", "Q54L24", "DDB_G0286945", "species_266099", "Q54L24", "DDB_G0286945", "DDB_G0287569" ] }, "reaction_10578651": { "compartment": "compartment_70101", "id": "reaction_10578651", "reactome": "R-DDI-71593", "name": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10578611" ], "products": [ "species_10578648", "species_70113" ], "modifiers": [ [ "species_10578616", "catalyst" ] ], "additional_components": [ "species_266099", "Q54L24", "DDB_G0286945", "species_266099", "Q54L24", "DDB_G0286945", "DDB_G0287569" ] }, "reaction_10578636": { "compartment": "compartment_70101", "id": "reaction_10578636", "reactome": "R-DDI-71590", "name": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_10578633" ], "products": [ "species_29548", "species_10578597" ], "modifiers": [ [ "species_10578628", "catalyst" ] ], "additional_components": [ "Q54L24", "DDB_G0286945", "species_266099", "Q54L24", "DDB_G0286945", "species_266099", "Q00766", "DDB_G0281383" ] }, "reaction_10602624": { "compartment": "compartment_70101", "id": "reaction_10602624", "reactome": "R-DDI-3322041", "name": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602568", "species_29410" ], "products": [ "species_10602621", "species_110096" ], "modifiers": [ [ "species_10602568", "catalyst" ], [ "species_30537", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945" ] }, "reaction_10602596": { "compartment": "compartment_70101", "id": "reaction_10602596", "reactome": "R-DDI-3322009", "name": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602591", "species_29410" ], "products": [ "species_110096", "species_10602593" ], "modifiers": [ [ "species_10602591", "catalyst" ] ], "additional_components": [ "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945" ] }, "reaction_10602628": { "compartment": "compartment_70101", "id": "reaction_10602628", "reactome": "R-DDI-3322057", "name": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602621" ], "products": [ "species_10602626" ], "modifiers": [ [ "species_10602581", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945", "DDB_G0274105" ] }, "reaction_10577673": { "compartment": "compartment_70101", "id": "reaction_10577673", "reactome": "R-DDI-70286", "name": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29548", "species_29494" ], "products": [ "species_111294", "species_29410" ], "modifiers": [ [ "species_10577670", "catalyst" ] ], "additional_components": [ "Q54YZ0", "DDB_G0277879" ] }, "reaction_10602601": { "compartment": "compartment_70101", "id": "reaction_10602601", "reactome": "R-DDI-3322014", "name": "Autoglucosylation of GYG2 complexed with GYS2-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602598", "species_29410" ], "products": [ "species_10602591", "species_110096" ], "modifiers": [ [ "species_10602598", "catalyst" ] ], "additional_components": [ "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945" ] }, "reaction_10602571": { "compartment": "compartment_70101", "id": "reaction_10602571", "reactome": "R-DDI-3322003", "name": "Autoglucosylation of GYG1 complexed with GYS1-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602566", "species_29410" ], "products": [ "species_10602568", "species_110096" ], "modifiers": [ [ "species_10602566", "catalyst" ] ], "additional_components": [ "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "species_29926", "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945", "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "species_29926" ] }, "reaction_10602605": { "compartment": "compartment_70101", "id": "reaction_10602605", "reactome": "R-DDI-3322016", "name": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602593" ], "products": [ "species_10602603" ], "modifiers": [ [ "species_10602581", "catalyst" ] ], "additional_components": [ "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "DDB_G0274105" ] }, "reaction_10602614": { "compartment": "compartment_70101", "id": "reaction_10602614", "reactome": "R-DDI-3322019", "name": "Autoglucosylation of GYG2 complexed with GYS2-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_10602609" ], "products": [ "species_10602611", "species_110096" ], "modifiers": [ [ "species_10602609", "catalyst" ] ], "additional_components": [ "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945" ] }, "reaction_10602584": { "compartment": "compartment_70101", "id": "reaction_10602584", "reactome": "R-DDI-3322005", "name": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602556" ], "products": [ "species_10602576" ], "modifiers": [ [ "species_10602581", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945", "DDB_G0274105" ] }, "reaction_10602619": { "compartment": "compartment_70101", "id": "reaction_10602619", "reactome": "R-DDI-3322025", "name": "Autoglucosylation of GYG1 complexed with GYS1-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602616", "species_29410" ], "products": [ "species_10602554", "species_110096" ], "modifiers": [ [ "species_10602616", "catalyst" ] ], "additional_components": [ "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "species_29926", "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945", "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "species_29926" ] }, "reaction_10626302": { "compartment": "compartment_70101", "id": "reaction_10626302", "reactome": "R-DDI-9638127", "name": "PGM1:Mg2+ isomerises G6P to G1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30537" ], "products": [ "species_29548" ], "modifiers": [ [ "species_10626297", "catalyst" ] ], "additional_components": [ "Q23919", "DDB_G0288483", "species_29926" ] }, "reaction_10602559": { "compartment": "compartment_70101", "id": "reaction_10602559", "reactome": "R-DDI-3322001", "name": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602554", "species_29410" ], "products": [ "species_10602556", "species_110096" ], "modifiers": [ [ "species_10602554", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945" ] }, "reaction_10624322": { "compartment": "compartment_70101", "id": "reaction_10624322", "reactome": "R-DDI-8982667", "name": "PGM2:Mg2+ isomerises dR1P to dR5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787326" ], "products": [ "species_6787328" ], "modifiers": [ [ "species_10577654", "catalyst" ] ], "additional_components": [ "Q54UQ2", "DDB_G0280897", "species_29926" ] }, "reaction_10578464": { "compartment": "compartment_70101", "id": "reaction_10578464", "reactome": "R-DDI-71299", "name": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29996", "species_29366" ], "products": [ "species_70106", "species_113528", "species_29364", "species_29732" ], "modifiers": [ [ "species_10578461", "catalyst" ] ], "additional_components": [ "Q8TA03", "DDB_G0277885" ] }, "reaction_10624007": { "compartment": "compartment_70101", "id": "reaction_10624007", "reactome": "R-DDI-8955844", "name": "RBKS phosphorylates ribose to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8955853" ], "products": [ "species_73578", "species_29370" ], "modifiers": [ [ "species_10624004", "catalyst" ] ], "additional_components": [ "DDB_G0280893" ] }, "reaction_10578502": { "compartment": "compartment_70101", "id": "reaction_10578502", "reactome": "R-DDI-71334", "name": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29578", "species_29882" ], "products": [ "species_29512", "species_29878" ], "modifiers": [ [ "species_10578499", "catalyst" ] ], "additional_components": [ "Q54UP4", "DDB_G0280909" ] }, "reaction_10587241": { "compartment": "compartment_70101", "id": "reaction_10587241", "reactome": "R-DDI-199803", "name": "xylulose 5-phosphate <=> D-ribulose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29790" ], "products": [ "species_29732" ], "modifiers": [ [ "species_10578481", "catalyst" ] ], "additional_components": [ "Q54YE7", "DDB_G0278275", "species_71067" ] }, "reaction_10582811": { "compartment": "compartment_70101", "id": "reaction_10582811", "reactome": "R-DDI-111215", "name": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73578", "species_110644" ], "products": [ "species_73566", "species_109386" ], "modifiers": [ [ "species_10580455", "catalyst" ], [ "species_29926", "catalyst" ], [ "species_29372", "catalyst" ] ], "additional_components": [ "Q75JN8", "DDB_G0272246", "Q54PA9", "DDB_G0284669", "Q54QU9", "DDB_G0283627" ] }, "reaction_10580462": { "compartment": "compartment_70101", "id": "reaction_10580462", "reactome": "R-DDI-73580", "name": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73578", "species_113592" ], "products": [ "species_73566", "species_76577" ], "modifiers": [ [ "species_10580459", "catalyst" ] ], "additional_components": [ "Q75JN8", "DDB_G0272246", "Q54PA9", "DDB_G0284669", "Q54QU9", "DDB_G0283627" ] }, "reaction_10585872": { "compartment": "compartment_70101", "id": "reaction_10585872", "reactome": "R-DDI-177784", "name": "ribose 5-phosphate <=> D-ribulose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73578" ], "products": [ "species_29732" ], "modifiers": [ [ "species_10578489", "catalyst" ] ], "additional_components": [ "DDB_G0276711" ] }, "reaction_10612693": { "compartment": "compartment_70101", "id": "reaction_10612693", "reactome": "R-DDI-6787329", "name": "PGM2:Mg2+ isomerises R1P to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_112016" ], "products": [ "species_73578" ], "modifiers": [ [ "species_10577654", "catalyst" ] ], "additional_components": [ "Q54UQ2", "DDB_G0280897", "species_29926" ] }, "reaction_10578484": { "compartment": "compartment_70101", "id": "reaction_10578484", "reactome": "R-DDI-71303", "name": "RPE dimers isomerise RU5P to XY5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29732" ], "products": [ "species_29790" ], "modifiers": [ [ "species_10578481", "catalyst" ] ], "additional_components": [ "Q54YE7", "DDB_G0278275", "species_71067" ] }, "reaction_10578454": { "compartment": "compartment_70101", "id": "reaction_10578454", "reactome": "R-DDI-71296", "name": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_31467" ], "products": [ "species_29996" ], "modifiers": [ [ "species_10578451", "catalyst" ] ], "additional_components": [ "DDB_G0292898" ] }, "reaction_10587707": { "compartment": "compartment_70101", "id": "reaction_10587707", "reactome": "R-DDI-203553", "name": "eNOS binds NOSIP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587546", "species_10587703" ], "products": [ "species_10587705" ], "modifiers": [], "additional_components": [ "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "DDB_G0270882", "Q55DU4", "DDB_G0270882", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596" ] }, "reaction_10587771": { "compartment": "compartment_876", "id": "reaction_10587771", "reactome": "R-DDI-203680", "name": "eNOS:NOSIP translocation from caveolae to intracellular compartments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587705" ], "products": [ "species_10587769" ], "modifiers": [], "additional_components": [ "Q55DU4", "DDB_G0270882", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_29870", "Q55DU4", "DDB_G0270882" ] }, "reaction_10578208": { "compartment": "compartment_5460", "id": "reaction_10578208", "reactome": "R-DDI-70982", "name": "Fumarate + H2O <=> (S)-Malate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113588", "species_113521" ], "products": [ "species_113544" ], "modifiers": [ [ "species_10578205", "catalyst" ] ], "additional_components": [ "Q54VA2", "DDB_G0280495" ] }, "reaction_10578755": { "compartment": "compartment_5460", "id": "reaction_10578755", "reactome": "R-DDI-71775", "name": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70958", "species_113548", "species_113525" ], "products": [ "species_29374", "species_113573", "species_113536" ], "modifiers": [ [ "species_10578752", "catalyst" ] ], "additional_components": [ "P36967", "DDB_G0289325", "Q869S7", "DDB_G0274449" ] }, "reaction_10578180": { "compartment": "compartment_5460", "id": "reaction_10578180", "reactome": "R-DDI-70967", "name": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_29938" ], "products": [ "species_113594", "species_113529", "species_29362", "species_29376" ], "modifiers": [ [ "species_10578177", "catalyst" ], [ "species_113581", "catalyst" ] ], "additional_components": [ "species_266099", "Q55BI2", "DDB_G0271344", "Q54B68", "DDB_G0293872" ] }, "reaction_10593319": { "compartment": "compartment_5462", "id": "reaction_10593319", "reactome": "R-DDI-450971", "name": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_113526", "species_113600" ], "products": [ "species_113563", "species_113529", "species_29362" ], "modifiers": [ [ "species_10593316", "catalyst" ] ], "additional_components": [ "Q55F30", "DDB_G0269046" ] }, "reaction_10624580": { "compartment": "compartment_5460", "id": "reaction_10624580", "reactome": "R-DDI-9012016", "name": "FAHD1:Zn2+ dimer hydrolyses OA to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113587" ], "products": [ "species_113557", "species_29376" ], "modifiers": [ [ "species_10624577", "catalyst" ] ], "additional_components": [ "species_29926", "Q86I22", "DDB_G0275071" ] }, "reaction_10593321": { "compartment": "compartment_5460", "id": "reaction_10593321", "reactome": "R-DDI-450975", "name": "isocitrate <=> citrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29938" ], "products": [ "species_29654" ], "modifiers": [ [ "species_10578185", "catalyst" ] ], "additional_components": [ "DDB_G0278779" ] }, "reaction_10578537": { "compartment": "compartment_5460", "id": "reaction_10578537", "reactome": "R-DDI-71401", "name": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113594", "species_113526" ], "products": [ "species_70958", "species_29362", "species_29376" ], "modifiers": [ [ "species_10578297", "catalyst" ] ], "additional_components": [ "CHEBI:17460", "Q869Y7", "DDB_G0275029", "Q54JE4", "DDB_G0288127", "species_8878387", "Q54EW8", "DDB_G0291648", "species_113596" ] }, "reaction_10578252": { "compartment": "compartment_5460", "id": "reaction_10578252", "reactome": "R-DDI-70997", "name": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70958", "species_113548", "species_113581" ], "products": [ "species_29374", "species_113593", "species_113536" ], "modifiers": [ [ "species_10578249", "catalyst" ] ], "additional_components": [ "P36967", "DDB_G0289325", "Q55AI5", "DDB_G0271842" ] }, "reaction_10578198": { "compartment": "compartment_5460", "id": "reaction_10578198", "reactome": "R-DDI-70975", "name": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559", "species_113587", "species_113521" ], "products": [ "species_29374", "species_29654" ], "modifiers": [ [ "species_10578195", "catalyst" ] ], "additional_components": [ "Q553V1", "DDB_G0275311" ] }, "reaction_10624629": { "compartment": "compartment_5460", "id": "reaction_10624629", "reactome": "R-DDI-9012349", "name": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_113544" ], "products": [ "species_113529", "species_113557", "species_113600", "species_29376" ], "modifiers": [ [ "species_10624626", "catalyst" ] ], "additional_components": [ "species_29926", "Q6TU48", "DDB_G0272524" ] }, "reaction_10578237": { "compartment": "compartment_5460", "id": "reaction_10578237", "reactome": "R-DDI-70994", "name": "Succinate <=> Fumarate (with FAD redox reaction on enzyme)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113536" ], "products": [ "species_113588" ], "modifiers": [ [ "species_10578234", "catalyst" ] ], "additional_components": [ "Q8T2T5", "DDB_G0275115", "Q9U3X4", "DDB_G0280535", "species_113596", "Q54YN1", "DDB_G0278157", "Q55CC2", "DDB_G0270120" ] }, "reaction_10624605": { "compartment": "compartment_5460", "id": "reaction_10624605", "reactome": "R-DDI-9012268", "name": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113544", "species_113526" ], "products": [ "species_113529", "species_113557", "species_29362", "species_29376" ], "modifiers": [ [ "species_10624602", "catalyst" ], [ "species_113588", "catalyst" ], [ "species_113593", "inhibitor" ] ], "additional_components": [ "Q6TU48", "DDB_G0272524", "species_29926" ] }, "reaction_10624594": { "compartment": "compartment_70101", "id": "reaction_10624594", "reactome": "R-DDI-9012036", "name": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_198498" ], "products": [ "species_70106", "species_113528", "species_29398", "species_29364" ], "modifiers": [ [ "species_10624591", "catalyst" ] ], "additional_components": [ "species_29926", "Q6TU48", "DDB_G0272524" ] }, "reaction_10612481": { "compartment": "compartment_70101", "id": "reaction_10612481", "reactome": "R-DDI-6783221", "name": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694130" ], "products": [ "species_29708", "species_29450" ], "modifiers": [ [ "species_10612478", "catalyst" ] ], "additional_components": [ "species_29426", "Q54MR1", "DDB_G0285717" ] }, "reaction_10578535": { "compartment": "compartment_5460", "id": "reaction_10578535", "reactome": "R-DDI-71397", "name": "lipo-PDH decarboxylates PYR to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_113557" ], "products": [ "species_113559", "species_29362", "species_29376" ], "modifiers": [ [ "species_10578532", "catalyst" ] ], "additional_components": [ "Q86AD5", "DDB_G0271564", "Q54C70", "DDB_G0292994", "Q86HX0", "DDB_G0276417", "species_8878387", "P36413", "DDB_G0277847", "Q54EW8", "DDB_G0291648", "species_113596" ] }, "reaction_10624632": { "compartment": "compartment_70101", "id": "reaction_10624632", "reactome": "R-DDI-9012374", "name": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398" ], "products": [ "species_9012375" ], "modifiers": [ [ "species_10604611", "catalyst" ] ], "additional_components": [ "DDB_G0271848" ] }, "reaction_10594272": { "compartment": "compartment_70616", "id": "reaction_10594272", "reactome": "R-DDI-880050", "name": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_880013" ], "products": [ "species_113594", "species_31649" ], "modifiers": [ [ "species_10594269", "catalyst" ] ], "additional_components": [ "DDB_G0267656" ] }, "reaction_10594262": { "compartment": "compartment_5460", "id": "reaction_10594262", "reactome": "R-DDI-880007", "name": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_879997" ], "products": [ "species_113594", "species_31649" ], "modifiers": [ [ "species_10594259", "catalyst" ], [ "species_880069", "catalyst" ], [ "species_880067", "catalyst" ], [ "species_113527", "catalyst" ] ], "additional_components": [ "DDB_G0270500" ] }, "reaction_10594264": { "compartment": "compartment_5460", "id": "reaction_10594264", "reactome": "R-DDI-880033", "name": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_880041" ], "products": [ "species_880046", "species_879997" ], "modifiers": [ [ "species_10594251", "catalyst" ] ], "additional_components": [ "DDB_G0290111" ] }, "reaction_10597540": { "compartment": "compartment_5460", "id": "reaction_10597540", "reactome": "R-DDI-1362416", "name": "Frataxin binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113531", "species_10597538" ], "products": [ "species_10597511" ], "modifiers": [], "additional_components": [ "Q54C45", "DDB_G0293246", "Q54X04", "DDB_G0279287", "Q54RP2", "DDB_G0283003", "Q54FN9", "DDB_G0290725", "Q54C45", "DDB_G0293246", "species_71067", "Q54X04", "DDB_G0279287", "Q54RP2", "DDB_G0283003", "Q54FN9", "DDB_G0290725" ] }, "reaction_10600913": { "compartment": "compartment_5460", "id": "reaction_10600913", "reactome": "R-DDI-2395512", "name": "FDXR transfers electrons to FDX1,2 (FDX1L)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597532", "species_10600909" ], "products": [ "species_10600911", "species_113529", "species_10597524" ], "modifiers": [], "additional_components": [ "CHEBI:33737", "Q55GW1", "DDB_G0267486", "species_31649", "Q54KG7", "DDB_G0287353", "Q54KG7", "DDB_G0287353", "species_113596", "Q55GW1", "DDB_G0267486", "CHEBI:33738" ] }, "reaction_10600915": { "compartment": "compartment_5460", "id": "reaction_10600915", "reactome": "R-DDI-2395517", "name": "NADPH transfers electrons to FDXR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600911", "species_113529", "species_113600" ], "products": [ "species_10600909", "species_113563" ], "modifiers": [], "additional_components": [ "Q54KG7", "DDB_G0287353", "species_113596", "species_31649", "Q54KG7", "DDB_G0287353" ] }, "reaction_10622794": { "compartment": "compartment_5460", "id": "reaction_10622794", "reactome": "R-DDI-8878815", "name": "Formation of 4Fe-4S cluster on ISCA1:ISCA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622773", "species_10622785" ], "products": [ "species_10622771", "species_10622787" ], "modifiers": [ [ "species_10622792", "catalyst" ] ], "additional_components": [ "Q555C8", "DDB_G0274657", "CHEBI:33739", "Q54VS1", "DDB_G0280173", "Q54P40", "DDB_G0284809", "DDB_G0274657", "Q54VS1", "DDB_G0280173", "Q54P40", "DDB_G0284809", "CHEBI:49883", "DDB_G0280889" ] }, "reaction_10597535": { "compartment": "compartment_5460", "id": "reaction_10597535", "reactome": "R-DDI-1362408", "name": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_379721", "species_10597511", "species_10597524" ], "products": [ "species_10597532", "species_10597526", "species_379697" ], "modifiers": [ [ "species_10597511", "catalyst" ], [ "species_10597524", "catalyst" ] ], "additional_components": [ "Q54C45", "DDB_G0293246", "species_71067", "Q54X04", "DDB_G0279287", "Q54RP2", "DDB_G0283003", "Q54FN9", "DDB_G0290725", "Q55GW1", "DDB_G0267486", "CHEBI:33738", "CHEBI:33737", "Q55GW1", "DDB_G0267486", "Q54C45", "DDB_G0293246", "Q54X04", "DDB_G0279287", "Q54RP2", "DDB_G0283003", "CHEBI:33739", "Q54FN9", "DDB_G0290725", "Q54C45", "DDB_G0293246", "species_71067", "Q54X04", "DDB_G0279287", "Q54RP2", "DDB_G0283003", "Q54FN9", "DDB_G0290725", "Q55GW1", "DDB_G0267486", "CHEBI:33738" ] }, "reaction_10584066": { "compartment": "compartment_7660", "id": "reaction_10584066", "reactome": "R-DDI-163664", "name": "AMP binds to gamma subunit of AMP kinase heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584060", "species_164121" ], "products": [ "species_10584064" ], "modifiers": [], "additional_components": [ "Q54YF2", "DDB_G0277905", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "species_76577" ] }, "reaction_10593844": { "compartment": "compartment_876", "id": "reaction_10593844", "reactome": "R-DDI-499981", "name": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10593841", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10590676": { "compartment": "compartment_876", "id": "reaction_10590676", "reactome": "R-DDI-399998", "name": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10590673", "catalyst" ] ], "additional_components": [ "species_29438" ] }, "reaction_10592344": { "compartment": "compartment_876", "id": "reaction_10592344", "reactome": "R-DDI-434381", "name": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_400452" ], "products": [ "species_3632881" ], "modifiers": [ [ "species_10592341", "catalyst" ] ], "additional_components": [ "Q9XYS8", "DDB_G0267406", "Q55FQ9", "DDB_G0267440", "Q9BKJ9", "DDB_G0287035" ] }, "reaction_10613507": { "compartment": "compartment_5460", "id": "reaction_10613507", "reactome": "R-DDI-6792572", "name": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611515", "species_10613491" ], "products": [ "species_10611517", "species_10613499" ], "modifiers": [ [ "species_10613504", "catalyst" ] ], "additional_components": [ "DDB_G0287773", "Q54VG0", "DDB_G0280353", "P36413", "DDB_G0277847", "Q86AD5", "DDB_G0271564", "Q54C70", "DDB_G0292994", "Q86HX0", "DDB_G0276417", "species_8878387", "Q54EW8", "DDB_G0291648", "species_113596", "CHEBI:17460", "Q869Y7", "DDB_G0275029", "Q54JE4", "DDB_G0288127", "Q55FN7", "DDB_G0268020", "Q54M22", "DDB_G0286335", "Q54TR7", "DDB_G0281797", "DDB_G0287773", "Q86AD5", "DDB_G0271564", "Q54C70", "DDB_G0292994", "Q86HX0", "DDB_G0276417", "species_8878387", "P36413", "DDB_G0277847", "Q54EW8", "DDB_G0291648", "species_113596", "Q54TR7", "DDB_G0281797", "Q55FN7", "DDB_G0268020", "Q54M22", "DDB_G0286335", "CHEBI:17460", "Q869Y7", "DDB_G0275029", "Q54JE4", "DDB_G0288127", "Q54VG0", "DDB_G0280353", "DDB_G0287107" ] }, "reaction_10590402": { "compartment": "compartment_17951", "id": "reaction_10590402", "reactome": "R-DDI-389821", "name": "glycine + O2 => glyoxylate + H2O2 + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_193446" ], "products": [ "species_389678", "species_389843", "species_113575" ], "modifiers": [ [ "species_10590399", "catalyst" ] ], "additional_components": [ "species_113596", "Q556W1", "DDB_G0273291" ] }, "reaction_10613525": { "compartment": "compartment_5460", "id": "reaction_10613525", "reactome": "R-DDI-6793590", "name": "LIPT2 transfers octanoyl group to GCSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611517", "species_10613514" ], "products": [ "species_10613517", "species_10613512" ], "modifiers": [ [ "species_10613522", "catalyst" ] ], "additional_components": [ "DDB_G0287773", "CHEBI:25650", "Q54E22", "DDB_G0291866", "DDB_G0287773", "DDB_G0291866", "DDB_G0275417" ] }, "reaction_10590342": { "compartment": "compartment_17951", "id": "reaction_10590342", "reactome": "R-DDI-389684", "name": "glyoxylate + alanine => glycine + pyruvate [peroxisome]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389678", "species_389664" ], "products": [ "species_389680", "species_193446" ], "modifiers": [ [ "species_10590339", "catalyst" ] ], "additional_components": [ "Q54GT6", "DDB_G0289923" ] }, "reaction_10590422": { "compartment": "compartment_17951", "id": "reaction_10590422", "reactome": "R-DDI-389842", "name": "HAO1 tetramer oxidizes glycolate to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389822" ], "products": [ "species_389678", "species_113575" ], "modifiers": [ [ "species_10590419", "catalyst" ] ], "additional_components": [ "species_76629", "Q54E41", "DDB_G0291814" ] }, "reaction_10590425": { "compartment": "compartment_17951", "id": "reaction_10590425", "reactome": "R-DDI-389862", "name": "Conversion of glyoxylate to oxalate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_389678" ], "products": [ "species_389819", "species_113575" ], "modifiers": [ [ "species_10590419", "catalyst" ] ], "additional_components": [ "species_76629", "Q54E41", "DDB_G0291814" ] }, "reaction_10612523": { "compartment": "compartment_5460", "id": "reaction_10612523", "reactome": "R-DDI-6784224", "name": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784215" ], "products": [ "species_6784241" ], "modifiers": [ [ "species_10612520", "catalyst" ] ], "additional_components": [ "Q86H28", "DDB_G0275669", "species_113596" ] }, "reaction_10590410": { "compartment": "compartment_17951", "id": "reaction_10590410", "reactome": "R-DDI-389826", "name": "glyoxylate + NADPH + H+ => glycolate + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193465", "species_389678", "species_113602" ], "products": [ "species_389822", "species_389556" ], "modifiers": [ [ "species_10590407", "catalyst" ] ], "additional_components": [ "DDB_G0292104" ] }, "reaction_10617423": { "compartment": "compartment_17951", "id": "reaction_10617423", "reactome": "R-DDI-6810076", "name": "DDO oxidizes D-Asp to OA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_6810061" ], "products": [ "species_113575", "species_389843", "species_6810070" ], "modifiers": [ [ "species_10617420", "catalyst" ] ], "additional_components": [ "species_113596", "Q556W1", "DDB_G0273291" ] }, "reaction_10612526": { "compartment": "compartment_5460", "id": "reaction_10612526", "reactome": "R-DDI-6784393", "name": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784236", "species_113587" ], "products": [ "species_6784229", "species_113553" ], "modifiers": [ [ "species_10577869", "catalyst" ] ], "additional_components": [ "Q55F21", "DDB_G0268664" ] }, "reaction_10600929": { "compartment": "compartment_70101", "id": "reaction_10600929", "reactome": "R-DDI-2408551", "name": "SeMet is converted to AdoSeMet by MAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5357707", "species_113592" ], "products": [ "species_111294", "species_29372", "species_5357652" ], "modifiers": [ [ "species_10585496", "catalyst" ] ], "additional_components": [ "Q54F07", "DDB_G0291179", "species_29926", "species_74126" ] }, "reaction_10624111": { "compartment": "compartment_70101", "id": "reaction_10624111", "reactome": "R-DDI-8959510", "name": "SEPHS2 phosphorylates H2Se to form SELP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5357660", "species_29356", "species_113592" ], "products": [ "species_29372", "species_70106", "species_8959518", "species_76577" ], "modifiers": [ [ "species_10624108", "catalyst" ] ], "additional_components": [ "DDB_G0282367" ] }, "reaction_10595831": { "compartment": "compartment_70101", "id": "reaction_10595831", "reactome": "R-DDI-977333", "name": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_977329", "species_29404" ], "products": [ "species_29406", "species_936706" ], "modifiers": [ [ "species_10595828", "catalyst" ] ], "additional_components": [ "Q55CQ6", "DDB_G0269950" ] }, "reaction_10625019": { "compartment": "compartment_70101", "id": "reaction_10625019", "reactome": "R-DDI-9014741", "name": "PXLP-K56-SRR dimer deaminates D-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_376186" ], "products": [ "species_29356", "species_29382", "species_29398" ], "modifiers": [ [ "species_10625016", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54HH2", "DDB_G0289463" ] }, "reaction_10625800": { "compartment": "compartment_70101", "id": "reaction_10625800", "reactome": "R-DDI-9034539", "name": "PXLP-K56-SRR dimer deaminates L-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_29356", "species_29382", "species_29398" ], "modifiers": [ [ "species_10625016", "catalyst" ] ], "additional_components": [ "Q54HH2", "DDB_G0289463" ] }, "reaction_10625022": { "compartment": "compartment_70101", "id": "reaction_10625022", "reactome": "R-DDI-9014766", "name": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_376186" ], "modifiers": [ [ "species_10625016", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54HH2", "DDB_G0289463" ] }, "reaction_10595820": { "compartment": "compartment_70101", "id": "reaction_10595820", "reactome": "R-DDI-977324", "name": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_936706" ], "products": [ "species_29372", "species_200736" ], "modifiers": [ [ "species_10595817", "catalyst" ] ], "additional_components": [ "Q54ES3", "DDB_G0291368", "species_29926" ] }, "reaction_10622893": { "compartment": "compartment_70101", "id": "reaction_10622893", "reactome": "R-DDI-8932980", "name": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_8932979" ], "modifiers": [ [ "species_10622882", "catalyst" ] ], "additional_components": [ "DDB_G0281099" ] }, "reaction_10585521": { "compartment": "compartment_70101", "id": "reaction_10585521", "reactome": "R-DDI-174401", "name": "AHCY:NAD+ tetramer hydrolyses AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_71285" ], "products": [ "species_83909", "species_174369" ], "modifiers": [ [ "species_10585518", "catalyst" ] ], "additional_components": [ "species_29360", "P10819", "DDB_G0267418" ] }, "reaction_10598480": { "compartment": "compartment_70101", "id": "reaction_10598480", "reactome": "R-DDI-1614583", "name": "PXLP-K212-CTH cleaves L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614518", "species_29356" ], "products": [ "species_111707", "species_29382", "species_936714" ], "modifiers": [ [ "species_10598474", "catalyst" ] ], "additional_components": [ "Q55DV9", "DDB_G0269122" ] }, "reaction_10598454": { "compartment": "compartment_70101", "id": "reaction_10598454", "reactome": "R-DDI-1614524", "name": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736", "species_174369" ], "products": [ "species_1614518", "species_29356" ], "modifiers": [ [ "species_10598451", "catalyst" ] ], "additional_components": [ "species_917877", "P46794", "DDB_G0267386" ] }, "reaction_10585499": { "compartment": "compartment_70101", "id": "reaction_10585499", "reactome": "R-DDI-174391", "name": "MAT1A multimers transfer Ado from ATP to L-Met", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_174390" ], "products": [ "species_111294", "species_29372", "species_71284" ], "modifiers": [ [ "species_10585496", "catalyst" ] ], "additional_components": [ "Q54F07", "DDB_G0291179", "species_29926", "species_74126" ] }, "reaction_10585483": { "compartment": "compartment_70101", "id": "reaction_10585483", "reactome": "R-DDI-174374", "name": "MTR transfers CH3 from MeCbl to HCYS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585476", "species_174369" ], "products": [ "species_10585480", "species_174390" ], "modifiers": [ [ "species_10585476", "catalyst" ] ], "additional_components": [ "Q54P92", "DDB_G0284699", "species_29426", "CHEBI:28115", "species_76629", "Q55G48", "DDB_G0267824", "species_113596", "Q54P92", "DDB_G0284699", "species_29426", "species_3159260", "species_76629", "Q55G48", "DDB_G0267824", "species_113596", "Q54P92", "DDB_G0284699", "species_29426", "CHEBI:28115", "species_76629", "Q55G48", "DDB_G0267824", "species_113596" ] }, "reaction_10597296": { "compartment": "compartment_70101", "id": "reaction_10597296", "reactome": "R-DDI-1237096", "name": "Methylthio-ribose-P = Methylthio-ribulose-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1237165" ], "products": [ "species_1237107" ], "modifiers": [ [ "species_10597293", "catalyst" ] ], "additional_components": [ "DDB_G0283309" ] }, "reaction_10597316": { "compartment": "compartment_70101", "id": "reaction_10597316", "reactome": "R-DDI-1237129", "name": "Acireductone is created", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1237176" ], "products": [ "species_29372", "species_70106", "species_1237155" ], "modifiers": [ [ "species_10597313", "catalyst" ] ], "additional_components": [ "species_29926", "Q55FM6", "DDB_G0268036" ] }, "reaction_10597306": { "compartment": "compartment_70101", "id": "reaction_10597306", "reactome": "R-DDI-1237119", "name": "Acireductone is oxidized to MOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_1237155" ], "products": [ "species_29460", "species_1237122" ], "modifiers": [ [ "species_10597303", "catalyst" ] ], "additional_components": [ "Q54ER6", "DDB_G0291376", "species_71067" ] }, "reaction_10577831": { "compartment": "compartment_70101", "id": "reaction_10577831", "reactome": "R-DDI-70523", "name": "PXLP-K314-GPT transaminates L-Ala to form PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29432" ], "products": [ "species_29404", "species_29398" ], "modifiers": [ [ "species_10577828", "catalyst" ] ], "additional_components": [ "Q54MJ7", "DDB_G0285899" ] }, "reaction_10593878": { "compartment": "compartment_5460", "id": "reaction_10593878", "reactome": "R-DDI-507749", "name": "PXLP-K341-GPT2 transaminates PYR to form L-Ala", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113557", "species_113552" ], "products": [ "species_113594", "species_379697" ], "modifiers": [ [ "species_10593875", "catalyst" ] ], "additional_components": [ "Q54MJ7", "DDB_G0285899" ] }, "reaction_10588674": { "compartment": "compartment_70101", "id": "reaction_10588674", "reactome": "R-DDI-209823", "name": "Tyrosine is hydroxylated to dopa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_29368", "species_29506" ], "products": [ "species_209849", "species_71112" ], "modifiers": [ [ "species_10588671", "catalyst" ] ], "additional_components": [ "species_71067", "Q54XS1", "DDB_G0278781" ] }, "reaction_10611411": { "compartment": "compartment_876", "id": "reaction_10611411", "reactome": "R-DDI-5693681", "name": "DUOX1,2 reduce O2 to H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_351627", "species_352327" ], "products": [ "species_351628", "species_351629" ], "modifiers": [ [ "species_10611408", "catalyst" ] ], "additional_components": [ "Q54F44", "DDB_G0291117", "Q86GL4", "DDB_G0287101", "Q9XYS3", "DDB_G0289653" ] }, "reaction_10589347": { "compartment": "compartment_984", "id": "reaction_10589347", "reactome": "R-DDI-350901", "name": "Iodide is organified", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_351627", "species_209818", "species_351629" ], "products": [ "species_109276", "species_351630", "species_351628" ], "modifiers": [ [ "species_10588619", "catalyst" ] ], "additional_components": [ "DDB_G0277275" ] }, "reaction_10588692": { "compartment": "compartment_984", "id": "reaction_10588692", "reactome": "R-DDI-209925", "name": "DIT and MIT combine to form triiodothyronine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352329", "species_351639" ], "products": [ "species_352331", "species_352036" ], "modifiers": [ [ "species_10588619", "catalyst" ] ], "additional_components": [ "DDB_G0277275" ] }, "reaction_10588694": { "compartment": "compartment_984", "id": "reaction_10588694", "reactome": "R-DDI-209973", "name": "Tyrosine is diiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_351627", "species_352030", "species_209818", "species_351629" ], "products": [ "species_109276", "species_352329", "species_351628" ], "modifiers": [ [ "species_10588619", "catalyst" ] ], "additional_components": [ "DDB_G0277275" ] }, "reaction_10589345": { "compartment": "compartment_70101", "id": "reaction_10589345", "reactome": "R-DDI-350869", "name": "Thyroxine is deiodinated to reverse triiodothyronine (RT3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_209937" ], "products": [ "species_209785", "species_176667", "species_29366" ], "modifiers": [ [ "species_10589342", "catalyst" ] ], "additional_components": [ "DDB_G0275741" ] }, "reaction_10588614": { "compartment": "compartment_70101", "id": "reaction_10588614", "reactome": "R-DDI-209772", "name": "Thyroxine is deiodinated to triiodothyronine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_209937" ], "products": [ "species_209785", "species_176667", "species_29366" ], "modifiers": [ [ "species_10588611", "catalyst" ] ], "additional_components": [ "Q552Y2", "DDB_G0275741" ] }, "reaction_10588685": { "compartment": "compartment_984", "id": "reaction_10588685", "reactome": "R-DDI-209840", "name": "Two DITs combine to form thyroxine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352329" ], "products": [ "species_352326", "species_352036" ], "modifiers": [ [ "species_10588619", "catalyst" ] ], "additional_components": [ "DDB_G0277275" ] }, "reaction_10588622": { "compartment": "compartment_984", "id": "reaction_10588622", "reactome": "R-DDI-209815", "name": "Tyrosine is monoiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351630", "species_352030" ], "products": [ "species_622410", "species_351639" ], "modifiers": [ [ "species_10588619", "catalyst" ] ], "additional_components": [ "DDB_G0277275" ] }, "reaction_10612514": { "compartment": "compartment_70101", "id": "reaction_10612514", "reactome": "R-DDI-6783955", "name": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_35305", "species_29364" ], "products": [ "species_29366", "species_113538" ], "modifiers": [ [ "species_10612511", "catalyst" ] ], "additional_components": [ "Q54IL7", "DDB_G0288671" ] }, "reaction_10577861": { "compartment": "compartment_5460", "id": "reaction_10577861", "reactome": "R-DDI-70589", "name": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_517496", "species_113594", "species_113529", "species_113561" ], "products": [ "species_113552", "species_113521", "species_517495" ], "modifiers": [ [ "species_10577858", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_29364", "species_192305", "species_29360", "species_29366", "Q54KB7", "DDB_G0287469" ] }, "reaction_10594292": { "compartment": "compartment_70101", "id": "reaction_10594292", "reactome": "R-DDI-893616", "name": "glutamine + pyruvate => 2-oxoglutaramate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398", "species_29472" ], "products": [ "species_29432", "species_893598" ], "modifiers": [ [ "species_10594283", "catalyst" ] ], "additional_components": [ "Q54KM6", "DDB_G0287269" ] }, "reaction_10577927": { "compartment": "compartment_5460", "id": "reaction_10577927", "reactome": "R-DDI-70664", "name": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113590", "species_29362" ], "products": [ "species_113526", "species_379717" ], "modifiers": [ [ "species_10577924", "catalyst" ] ], "additional_components": [ "Q54IL7", "DDB_G0288671" ] }, "reaction_10577929": { "compartment": "compartment_5460", "id": "reaction_10577929", "reactome": "R-DDI-70666", "name": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31339", "species_113552" ], "products": [ "species_113594", "species_113585" ], "modifiers": [ [ "species_10577914", "catalyst" ] ], "additional_components": [ "Q54JP5", "DDB_G0287913" ] }, "reaction_10612507": { "compartment": "compartment_5460", "id": "reaction_10612507", "reactome": "R-DDI-6783939", "name": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113590", "species_29362" ], "products": [ "species_113526", "species_379717" ], "modifiers": [ [ "species_10612504", "catalyst" ] ], "additional_components": [ "Q54IL7", "DDB_G0288671" ] }, "reaction_10577884": { "compartment": "compartment_5460", "id": "reaction_10577884", "reactome": "R-DDI-70600", "name": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113552", "species_113521", "species_517495" ], "products": [ "species_517496", "species_113594", "species_113529", "species_113561" ], "modifiers": [ [ "species_10577858", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_29360", "species_29366", "species_29364", "species_192305", "Q54KB7", "DDB_G0287469" ] }, "reaction_10578387": { "compartment": "compartment_70101", "id": "reaction_10578387", "reactome": "R-DDI-71164", "name": "homogentisate + O2 => maleylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_30337" ], "products": [ "species_31135" ], "modifiers": [ [ "species_10578384", "catalyst" ] ], "additional_components": [ "species_71067", "Q54QI4", "DDB_G0283765" ] }, "reaction_10578407": { "compartment": "compartment_70101", "id": "reaction_10578407", "reactome": "R-DDI-71181", "name": "fumarylacetoacetate => fumarate + acetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_31175" ], "products": [ "species_29666", "species_29586" ], "modifiers": [ [ "species_10578404", "catalyst" ] ], "additional_components": [ "Q1ZXQ1", "DDB_G0271094" ] }, "reaction_10578358": { "compartment": "compartment_70101", "id": "reaction_10578358", "reactome": "R-DDI-71155", "name": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29506" ], "products": [ "species_29404", "species_31365" ], "modifiers": [ [ "species_10578355", "catalyst" ] ], "additional_components": [ "Q54K95", "DDB_G0287515" ] }, "reaction_10578377": { "compartment": "compartment_70101", "id": "reaction_10578377", "reactome": "R-DDI-71163", "name": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_31365" ], "products": [ "species_113528", "species_30337" ], "modifiers": [ [ "species_10578374", "catalyst" ] ], "additional_components": [ "Q76NV5", "DDB_G0277511", "Q557J8", "DDB_G0273429", "species_198816", "species_71067" ] }, "reaction_10578397": { "compartment": "compartment_70101", "id": "reaction_10578397", "reactome": "R-DDI-71173", "name": "maleylacetoacetate => fumarylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31135" ], "products": [ "species_31175" ], "modifiers": [ [ "species_10578394", "catalyst" ] ], "additional_components": [ "Q54YN2", "DDB_G0278155", "species_29450" ] }, "reaction_10600401": { "compartment": "compartment_984", "id": "reaction_10600401", "reactome": "R-DDI-2160492", "name": "IL4I1:FAD oxidises L-Phe to kPPV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_351993", "species_352327" ], "products": [ "species_2022135", "species_351629", "species_2160466" ], "modifiers": [ [ "species_10600398", "catalyst" ] ], "additional_components": [ "species_113596", "Q54EW2", "DDB_G0293662", "Q55B17", "DDB_G0293662", "Q54BE7", "DDB_G0293662", "Q55B19", "DDB_G0293662" ] }, "reaction_10578320": { "compartment": "compartment_70101", "id": "reaction_10578320", "reactome": "R-DDI-71118", "name": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_29502", "species_29368" ], "products": [ "species_71112", "species_29506" ], "modifiers": [ [ "species_10578317", "catalyst" ] ], "additional_components": [ "Q54XS1", "DDB_G0278781", "species_71067" ] }, "reaction_10578347": { "compartment": "compartment_70101", "id": "reaction_10578347", "reactome": "R-DDI-71146", "name": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71112" ], "products": [ "species_29356", "species_71129" ], "modifiers": [ [ "species_10578344", "catalyst" ] ], "additional_components": [ "Q54XF6", "DDB_G0278993", "Q54RY8", "DDB_G0282831" ] }, "reaction_10578330": { "compartment": "compartment_70101", "id": "reaction_10578330", "reactome": "R-DDI-71130", "name": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_71129", "species_73473" ], "products": [ "species_29870", "species_29360" ], "modifiers": [ [ "species_10578327", "catalyst" ] ], "additional_components": [ "Q86A17", "DDB_G0272684" ] }, "reaction_10594286": { "compartment": "compartment_70101", "id": "reaction_10594286", "reactome": "R-DDI-893593", "name": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29502", "species_29398" ], "products": [ "species_29432", "species_893599" ], "modifiers": [ [ "species_10594283", "catalyst" ] ], "additional_components": [ "Q54KM6", "DDB_G0287269" ] }, "reaction_10577841": { "compartment": "compartment_5460", "id": "reaction_10577841", "reactome": "R-DDI-70542", "name": "glutamate + acetyl CoA => N-acetyl glutamate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559", "species_113552" ], "products": [ "species_29374", "species_30471" ], "modifiers": [ [ "species_10577838", "catalyst" ], [ "species_374064", "catalyst" ] ], "additional_components": [ "DDB_G0286257" ] }, "reaction_10577906": { "compartment": "compartment_70101", "id": "reaction_10577906", "reactome": "R-DDI-70634", "name": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113567", "species_29498" ], "products": [ "species_113585", "species_29968" ], "modifiers": [ [ "species_10577903", "catalyst" ] ], "additional_components": [ "Q54FE6", "DDB_G0290913", "Q55E85", "DDB_G0269352", "Q86HN8", "DDB_G0274501" ] }, "reaction_10593352": { "compartment": "compartment_5460", "id": "reaction_10593352", "reactome": "R-DDI-452036", "name": "arginine + H2O => ornithine + urea [ARG2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_374064", "species_113521" ], "products": [ "species_374061", "species_113585" ], "modifiers": [ [ "species_10593349", "catalyst" ] ], "additional_components": [ "Q54HV8", "DDB_G0289195", "species_266099" ] }, "reaction_10577851": { "compartment": "compartment_70101", "id": "reaction_10577851", "reactome": "R-DDI-70569", "name": "arginine + H2O => ornithine + urea [ARG1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29468" ], "products": [ "species_29514", "species_29498" ], "modifiers": [ [ "species_10577848", "catalyst" ] ], "additional_components": [ "Q54HV8", "DDB_G0289195", "species_266099" ] }, "reaction_10577872": { "compartment": "compartment_5460", "id": "reaction_10577872", "reactome": "R-DDI-70596", "name": "GOT2 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113553" ], "products": [ "species_113587", "species_113552" ], "modifiers": [ [ "species_10577869", "catalyst" ] ], "additional_components": [ "Q55F21", "DDB_G0268664" ] }, "reaction_10613589": { "compartment": "compartment_70101", "id": "reaction_10613589", "reactome": "R-DDI-6797627", "name": "ASPG hydrolyses L-Asn to L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29642" ], "products": [ "species_29448", "species_29382" ], "modifiers": [ [ "species_10613586", "catalyst" ] ], "additional_components": [ "DDB_G0271924" ] }, "reaction_10577882": { "compartment": "compartment_70101", "id": "reaction_10577882", "reactome": "R-DDI-70599", "name": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_29448", "species_29472" ], "products": [ "species_111294", "species_29404", "species_29642", "species_76577" ], "modifiers": [ [ "species_10577879", "catalyst" ] ], "additional_components": [ "Q54MB4", "DDB_G0286059" ] }, "reaction_10623961": { "compartment": "compartment_5460", "id": "reaction_10623961", "reactome": "R-DDI-8954468", "name": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559", "species_113553" ], "products": [ "species_29374", "species_8954466", "species_113529" ], "modifiers": [ [ "species_10623958", "catalyst" ] ], "additional_components": [ "Q54IG0", "DDB_G0293514", "Q54BP5", "DDB_G0293514" ] }, "reaction_10578417": { "compartment": "compartment_70101", "id": "reaction_10578417", "reactome": "R-DDI-71188", "name": "TDO tetramer dioxygenates L-Trp to NFK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29500", "species_29368" ], "products": [ "species_33179" ], "modifiers": [ [ "species_10578414", "catalyst" ] ], "additional_components": [ "species_917877", "Q55DB4", "DDB_G0269714" ] }, "reaction_10594289": { "compartment": "compartment_70101", "id": "reaction_10594289", "reactome": "R-DDI-893596", "name": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398", "species_29970" ], "products": [ "species_29432", "species_893615" ], "modifiers": [ [ "species_10594283", "catalyst" ], [ "species_29502", "inhibitor" ], [ "species_8939576", "inhibitor" ] ], "additional_components": [ "Q54KM6", "DDB_G0287269", "CHEBI:55528", "CHEBI:43580" ] }, "reaction_10594275": { "compartment": "compartment_5460", "id": "reaction_10594275", "reactome": "R-DDI-893583", "name": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_893607" ], "products": [ "species_893617", "species_113552" ], "modifiers": [ [ "species_10578160", "catalyst" ] ], "additional_components": [ "Q54K00", "DDB_G0287711" ] }, "reaction_10578436": { "compartment": "compartment_70101", "id": "reaction_10578436", "reactome": "R-DDI-71217", "name": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_34351", "species_29356" ], "products": [ "species_29432", "species_30487" ], "modifiers": [ [ "species_10578433", "catalyst" ] ], "additional_components": [ "Q54Q04", "DDB_G0284203" ] }, "reaction_10578425": { "compartment": "compartment_70101", "id": "reaction_10578425", "reactome": "R-DDI-71200", "name": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_29970" ], "products": [ "species_34351", "species_29356", "species_29366" ], "modifiers": [ [ "species_10578422", "catalyst" ] ], "additional_components": [ "DDB_G0283173" ] }, "reaction_10620687": { "compartment": "compartment_876", "id": "reaction_10620687", "reactome": "R-DDI-8870352", "name": "SLC36A4 transports L-Trp from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352006" ], "products": [ "species_29500" ], "modifiers": [ [ "species_10620684", "catalyst" ] ], "additional_components": [ "DDB_G0293074" ] }, "reaction_10578446": { "compartment": "compartment_70101", "id": "reaction_10578446", "reactome": "R-DDI-71218", "name": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_30487" ], "products": [ "species_36027" ], "modifiers": [ [ "species_10578443", "catalyst" ] ], "additional_components": [ "Q54S02", "DDB_G0282743", "species_71067" ] }, "reaction_10606628": { "compartment": "compartment_5668575", "id": "reaction_10606628", "reactome": "R-DDI-5662662", "name": "Tyrosinase oxidises tyrosine to dopaquinone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5668573", "species_5668567" ], "products": [ "species_5668577", "species_5662695" ], "modifiers": [ [ "species_10606620", "catalyst" ], [ "species_10606626", "catalyst" ] ], "additional_components": [ "Q54QT0", "DDB_G0283653", "Q54QT1", "DDB_G0283653", "species_437295", "DDB_G0276801" ] }, "reaction_10606612": { "compartment": "compartment_5668572", "id": "reaction_10606612", "reactome": "R-DDI-5662660", "name": "Dopachrome is transformed to DHICA by DCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5662665" ], "products": [ "species_5662670" ], "modifiers": [ [ "species_10606609", "catalyst" ] ], "additional_components": [ "species_29426", "Q54QT0", "DDB_G0283653", "Q54QT1", "DDB_G0283653" ] }, "reaction_10606631": { "compartment": "compartment_5668572", "id": "reaction_10606631", "reactome": "R-DDI-5662692", "name": "Dopa is oxidized to dopaquinone by TYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5668568", "species_5668566" ], "products": [ "species_5668574", "species_5662695" ], "modifiers": [ [ "species_10606620", "catalyst" ] ], "additional_components": [ "Q54QT0", "DDB_G0283653", "Q54QT1", "DDB_G0283653", "species_437295" ] }, "reaction_10606633": { "compartment": "compartment_5668572", "id": "reaction_10606633", "reactome": "R-DDI-5663050", "name": "DHI and DHICA polymerise forming eumelanin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5662708", "species_5662695" ], "products": [ "species_5668568", "species_5662678" ], "modifiers": [ [ "species_10606620", "catalyst" ] ], "additional_components": [ "species_5662670", "CHEBI:27404", "species_5662670", "CHEBI:27404", "Q54QT0", "DDB_G0283653", "Q54QT1", "DDB_G0283653", "species_437295" ] }, "reaction_10622761": { "compartment": "compartment_5668575", "id": "reaction_10622761", "reactome": "R-DDI-8878581", "name": "TYRP1 oxidises DHICA to IQCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5662670", "species_5668566" ], "products": [ "species_8878586", "species_5668574" ], "modifiers": [ [ "species_10622758", "catalyst" ] ], "additional_components": [ "Q54QT0", "DDB_G0283653", "Q54QT1", "DDB_G0283653" ] }, "reaction_10578017": { "compartment": "compartment_5460", "id": "reaction_10578017", "reactome": "R-DDI-70785", "name": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70772", "species_113521" ], "products": [ "species_70784" ], "modifiers": [ [ "species_10578014", "catalyst" ] ], "additional_components": [ "Q54HG7", "DDB_G0289471" ] }, "reaction_10593920": { "compartment": "compartment_5460", "id": "reaction_10593920", "reactome": "R-DDI-508369", "name": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_70836", "species_29362" ], "products": [ "species_70829", "species_113526" ], "modifiers": [ [ "species_10578034", "catalyst" ] ], "additional_components": [ "Q86JE3", "DDB_G0272128" ] }, "reaction_10593922": { "compartment": "compartment_5460", "id": "reaction_10593922", "reactome": "R-DDI-508473", "name": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_30004", "species_29362" ], "products": [ "species_113526", "species_573404" ], "modifiers": [ [ "species_10578082", "catalyst" ] ], "additional_components": [ "Q54CX6", "DDB_G0292566" ] }, "reaction_10577989": { "compartment": "compartment_70101", "id": "reaction_10577989", "reactome": "R-DDI-70723", "name": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_508182" ], "products": [ "species_29404", "species_508187" ], "modifiers": [ [ "species_10577986", "catalyst" ] ], "additional_components": [ "species_29588", "CHEBI:58045", "CHEBI:57762", "CHEBI:28654", "CHEBI:17865", "CHEBI:16530", "Q54N47", "DDB_G0285509" ] }, "reaction_10578057": { "compartment": "compartment_5460", "id": "reaction_10578057", "reactome": "R-DDI-70859", "name": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70851" ], "products": [ "species_70858", "species_31649" ], "modifiers": [ [ "species_10578054", "catalyst" ] ], "additional_components": [ "Q54IM8", "DDB_G0288647", "species_113596" ] }, "reaction_10578027": { "compartment": "compartment_5460", "id": "reaction_10578027", "reactome": "R-DDI-70800", "name": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70718", "species_113596" ], "products": [ "species_70799", "species_31649" ], "modifiers": [ [ "species_10578024", "catalyst" ] ], "additional_components": [ "Q54RR5", "DDB_G0282967", "species_113596" ] }, "reaction_10577997": { "compartment": "compartment_5460", "id": "reaction_10577997", "reactome": "R-DDI-70724", "name": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_508190" ], "products": [ "species_508181", "species_113552" ], "modifiers": [ [ "species_10577994", "catalyst" ] ], "additional_components": [ "CHEBI:58045", "CHEBI:57762", "species_29588", "CHEBI:16530", "CHEBI:28654", "CHEBI:17865", "Q54N47", "DDB_G0285509" ] }, "reaction_10578093": { "compartment": "compartment_5460", "id": "reaction_10578093", "reactome": "R-DDI-70893", "name": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_30004" ], "products": [ "species_70843", "species_113529", "species_29362", "species_29376" ], "modifiers": [ [ "species_10578090", "catalyst" ] ], "additional_components": [ "DDB_G0289085" ] }, "reaction_10578067": { "compartment": "compartment_5460", "id": "reaction_10578067", "reactome": "R-DDI-70870", "name": "ECHS1 hydrates methacrylyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70858", "species_113521" ], "products": [ "species_71847" ], "modifiers": [ [ "species_10578064", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10578007": { "compartment": "compartment_5460", "id": "reaction_10578007", "reactome": "R-DDI-70745", "name": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70715" ], "products": [ "species_70744", "species_31649" ], "modifiers": [ [ "species_10578004", "catalyst" ] ], "additional_components": [ "Q54W88", "DDB_G0279827", "species_113596" ] }, "reaction_10578075": { "compartment": "compartment_5460", "id": "reaction_10578075", "reactome": "R-DDI-70881", "name": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71847", "species_113521" ], "products": [ "species_29374", "species_573404" ], "modifiers": [ [ "species_10578072", "catalyst" ] ], "additional_components": [ "DDB_G0267536" ] }, "reaction_10577978": { "compartment": "compartment_5460", "id": "reaction_10577978", "reactome": "R-DDI-70713", "name": "BCKDH transfers CoA group from CoA-SH to BCAAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_508181" ], "products": [ "species_29362", "species_508261", "species_29376" ], "modifiers": [ [ "species_10577975", "catalyst" ] ], "additional_components": [ "CHEBI:16530", "CHEBI:28654", "CHEBI:17865", "species_70851", "species_70715", "species_70718", "Q54TR7", "DDB_G0281797", "Q55FN7", "DDB_G0268020", "species_8878387", "Q54M22", "DDB_G0286335", "Q54EW8", "DDB_G0291648", "species_113596" ] }, "reaction_10578047": { "compartment": "compartment_5460", "id": "reaction_10578047", "reactome": "R-DDI-70844", "name": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_70836" ], "products": [ "species_70843", "species_113559" ], "modifiers": [ [ "species_10578044", "catalyst" ] ], "additional_components": [ "Q86AD9", "DDB_G0271544" ] }, "reaction_10589365": { "compartment": "compartment_70101", "id": "reaction_10589365", "reactome": "R-DDI-351215", "name": "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353113", "species_29610" ], "products": [ "species_204635", "species_353106" ], "modifiers": [ [ "species_10589362", "catalyst" ] ], "additional_components": [ "DDB_G0268630" ] }, "reaction_10589355": { "compartment": "compartment_70101", "id": "reaction_10589355", "reactome": "R-DDI-351207", "name": "Spermine => N-acetylated spermine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353560", "species_76183" ], "products": [ "species_76194", "species_353575" ], "modifiers": [ [ "species_10589352", "catalyst" ] ], "additional_components": [ "DDB_G0279851" ] }, "reaction_10589357": { "compartment": "compartment_70101", "id": "reaction_10589357", "reactome": "R-DDI-351208", "name": "Spermidine => N-acetylated spermidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_204635", "species_76183" ], "products": [ "species_353555", "species_76194" ], "modifiers": [ [ "species_10589352", "catalyst" ] ], "additional_components": [ "DDB_G0279851" ] }, "reaction_10577946": { "compartment": "compartment_70101", "id": "reaction_10577946", "reactome": "R-DDI-70692", "name": "ornithine => putrescine + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29498" ], "products": [ "species_29610", "species_113528" ], "modifiers": [ [ "species_10577943", "catalyst" ] ], "additional_components": [ "DDB_G0281109" ] }, "reaction_10589373": { "compartment": "compartment_70101", "id": "reaction_10589373", "reactome": "R-DDI-351222", "name": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284" ], "products": [ "species_353113", "species_113528" ], "modifiers": [ [ "species_10589370", "catalyst" ] ], "additional_components": [ "DDB_G0275567" ] }, "reaction_10578163": { "compartment": "compartment_5460", "id": "reaction_10578163", "reactome": "R-DDI-70952", "name": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_508531" ], "products": [ "species_70951", "species_113552" ], "modifiers": [ [ "species_10578160", "catalyst" ] ], "additional_components": [ "Q54K00", "DDB_G0287711" ] }, "reaction_10612802": { "compartment": "compartment_5460", "id": "reaction_10612802", "reactome": "R-DDI-6788611", "name": "HYKK phosphorylates 5HLYS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788606", "species_113573" ], "products": [ "species_5696409", "species_113525" ], "modifiers": [ [ "species_10612799", "catalyst" ] ], "additional_components": [ "DDB_G0295739" ] }, "reaction_10612500": { "compartment": "compartment_17951", "id": "reaction_10612500", "reactome": "R-DDI-6783880", "name": "PIPOX oxidises PPCA to P6C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_5693325" ], "products": [ "species_113575", "species_6783877" ], "modifiers": [ [ "species_10612497", "catalyst" ] ], "additional_components": [ "DDB_G0280851" ] }, "reaction_10589556": { "compartment": "compartment_5460", "id": "reaction_10589556", "reactome": "R-DDI-372480", "name": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113577" ], "products": [ "species_29406", "species_70951" ], "modifiers": [ [ "species_10589553", "catalyst" ] ], "additional_components": [ "DDB_G0267704" ] }, "reaction_10578310": { "compartment": "compartment_5460", "id": "reaction_10578310", "reactome": "R-DDI-71046", "name": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70955" ], "products": [ "species_71045", "species_31649", "species_29376" ], "modifiers": [ [ "species_10578307", "catalyst" ] ], "additional_components": [ "Q54R47", "DDB_G0283411", "species_113596" ] }, "reaction_10578152": { "compartment": "compartment_5460", "id": "reaction_10578152", "reactome": "R-DDI-70941", "name": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_113556", "species_113521" ], "products": [ "species_113529", "species_508531", "species_29362" ], "modifiers": [ [ "species_10578149", "catalyst" ] ], "additional_components": [ "P83401", "DDB_G0276821" ] }, "reaction_10578139": { "compartment": "compartment_5460", "id": "reaction_10578139", "reactome": "R-DDI-70938", "name": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113529", "species_29444", "species_113600" ], "products": [ "species_113563", "species_113521", "species_30176" ], "modifiers": [ [ "species_10578136", "catalyst" ] ], "additional_components": [ "Q54NG9", "DDB_G0285267" ] }, "reaction_10611324": { "compartment": "compartment_17951", "id": "reaction_10611324", "reactome": "R-DDI-5693347", "name": "CRYM reduces P2C to PPCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193465", "species_5693311", "species_113602" ], "products": [ "species_5693325", "species_389556" ], "modifiers": [ [ "species_10611321", "catalyst" ] ], "additional_components": [ "DDB_G0292894" ] }, "reaction_10578300": { "compartment": "compartment_5460", "id": "reaction_10578300", "reactome": "R-DDI-71037", "name": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_70951" ], "products": [ "species_70955", "species_29362", "species_29376" ], "modifiers": [ [ "species_10578297", "catalyst" ] ], "additional_components": [ "CHEBI:17460", "Q869Y7", "DDB_G0275029", "Q54JE4", "DDB_G0288127", "species_8878387", "Q54EW8", "DDB_G0291648", "species_113596" ] }, "reaction_10578142": { "compartment": "compartment_5460", "id": "reaction_10578142", "reactome": "R-DDI-70940", "name": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_113521", "species_30176" ], "products": [ "species_113529", "species_113556", "species_29362", "species_113552" ], "modifiers": [ [ "species_10578136", "catalyst" ] ], "additional_components": [ "Q54NG9", "DDB_G0285267" ] }, "reaction_10578129": { "compartment": "compartment_70101", "id": "reaction_10578129", "reactome": "R-DDI-70920", "name": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30158", "species_111355" ], "products": [ "species_29404", "species_70919" ], "modifiers": [ [ "species_10578126", "catalyst" ] ], "additional_components": [ "Q54JL3", "DDB_G0287977" ] }, "reaction_10578101": { "compartment": "compartment_70101", "id": "reaction_10578101", "reactome": "R-DDI-70899", "name": "histidine => urocanate + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29612" ], "products": [ "species_31633", "species_30721" ], "modifiers": [ [ "species_10578098", "catalyst" ] ], "additional_components": [ "DDB_G0288025" ] }, "reaction_10578119": { "compartment": "compartment_70101", "id": "reaction_10578119", "reactome": "R-DDI-70906", "name": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_34979" ], "products": [ "species_30158", "species_70106" ], "modifiers": [ [ "species_10578116", "catalyst" ] ], "additional_components": [ "DDB_G0269854" ] }, "reaction_10622372": { "compartment": "compartment_70101", "id": "reaction_10622372", "reactome": "R-DDI-8876789", "name": "CARNMT1 methylates CARN to Anserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6786250", "species_71284" ], "products": [ "species_71285", "species_8876775" ], "modifiers": [ [ "species_10622369", "catalyst" ] ], "additional_components": [ "DDB_G0282239" ] }, "reaction_10578111": { "compartment": "compartment_70101", "id": "reaction_10578111", "reactome": "R-DDI-70903", "name": "urocanate + H2O => 4-imidazolone-5-propionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30721" ], "products": [ "species_34979" ], "modifiers": [ [ "species_10578108", "catalyst" ] ], "additional_components": [ "species_29360", "Q86AX3", "DDB_G0277727" ] }, "reaction_10613621": { "compartment": "compartment_70101", "id": "reaction_10613621", "reactome": "R-DDI-6797956", "name": "SLC44A1 transports Cho from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264618" ], "products": [ "species_6798162" ], "modifiers": [ [ "species_10613618", "catalyst" ] ], "additional_components": [ "Q54IJ2", "DDB_G0288717", "Q54I48", "DDB_G0289013" ] }, "reaction_10613629": { "compartment": "compartment_5460", "id": "reaction_10613629", "reactome": "R-DDI-6797961", "name": "CHDH oxidises Cho to BETALD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_6798162" ], "products": [ "species_6798194", "species_31649" ], "modifiers": [ [ "species_10613626", "catalyst" ] ], "additional_components": [ "DDB_G0287229" ] }, "reaction_10613612": { "compartment": "compartment_5460", "id": "reaction_10613612", "reactome": "R-DDI-6797955", "name": "ALDH7A1 oxidises BETALD to BET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_6798194", "species_113521" ], "products": [ "species_6798202", "species_29362" ], "modifiers": [ [ "species_10578147", "catalyst" ] ], "additional_components": [ "DDB_G0276821" ] }, "reaction_10580773": { "compartment": "compartment_5460", "id": "reaction_10580773", "reactome": "R-DDI-73916", "name": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559" ], "products": [ "species_29374", "species_73871" ], "modifiers": [ [ "species_10578044", "catalyst" ] ], "additional_components": [ "Q86AD9", "DDB_G0271544" ] }, "reaction_10621991": { "compartment": "compartment_5460", "id": "reaction_10621991", "reactome": "R-DDI-8875071", "name": "ACSS3 ligates CoA to CH3COO-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_113539" ], "products": [ "species_159448", "species_159450", "species_113559" ], "modifiers": [ [ "species_10621988", "catalyst" ] ], "additional_components": [ "DDB_G0274939" ] }, "reaction_10580788": { "compartment": "compartment_5460", "id": "reaction_10580788", "reactome": "R-DDI-73918", "name": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73871", "species_113559" ], "products": [ "species_29374", "species_73917" ], "modifiers": [ [ "species_10580785", "catalyst" ] ], "additional_components": [ "P54872", "DDB_G0288461", "Q86HL5", "DDB_G0274871" ] }, "reaction_10581175": { "compartment": "compartment_5460", "id": "reaction_10581175", "reactome": "R-DDI-74180", "name": "HMG CoA => acetoacetic acid + acetyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73917" ], "products": [ "species_113559", "species_73909" ], "modifiers": [ [ "species_10581172", "catalyst" ] ], "additional_components": [ "Q54QI7", "DDB_G0283813" ] }, "reaction_10612794": { "compartment": "compartment_70101", "id": "reaction_10612794", "reactome": "R-DDI-6788597", "name": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191374" ], "products": [ "species_76183", "species_29666" ], "modifiers": [ [ "species_10612791", "catalyst" ] ], "additional_components": [ "Q54QI7", "DDB_G0283813", "species_29926" ] }, "reaction_10581165": { "compartment": "compartment_5460", "id": "reaction_10581165", "reactome": "R-DDI-74177", "name": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70958", "species_73909" ], "products": [ "species_73871", "species_113536" ], "modifiers": [ [ "species_10581162", "catalyst" ] ], "additional_components": [ "Q54JD9", "DDB_G0288105" ] }, "reaction_10600081": { "compartment": "compartment_17957", "id": "reaction_10600081", "reactome": "R-DDI-2046088", "name": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046052", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2046051", "species_162743", "species_159751" ], "modifiers": [ [ "species_10593966", "catalyst" ] ], "additional_components": [ "Q55BY4", "DDB_G0271066", "C7FZW5", "DDB_G0271066" ] }, "reaction_10600112": { "compartment": "compartment_17951", "id": "reaction_10600112", "reactome": "R-DDI-2066778", "name": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_2066767" ], "products": [ "species_2066766" ], "modifiers": [ [ "species_10586623", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10600083": { "compartment": "compartment_17957", "id": "reaction_10600083", "reactome": "R-DDI-2046090", "name": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046057", "species_113601" ], "products": [ "species_113519", "species_2046065", "species_113564", "species_162743", "species_159751" ], "modifiers": [ [ "species_10593964", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10600114": { "compartment": "compartment_17951", "id": "reaction_10600114", "reactome": "R-DDI-2066780", "name": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2066766" ], "products": [ "species_2066762" ], "modifiers": [ [ "species_10586623", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10600116": { "compartment": "compartment_17951", "id": "reaction_10600116", "reactome": "R-DDI-2066787", "name": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_2046047" ], "products": [ "species_113575", "species_2066767" ], "modifiers": [ [ "species_10590470", "catalyst" ] ], "additional_components": [ "Q54GQ6", "DDB_G0289993", "species_113596" ] }, "reaction_10600119": { "compartment": "compartment_17951", "id": "reaction_10600119", "reactome": "R-DDI-2066788", "name": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193514", "species_2066762" ], "products": [ "species_353123", "species_2066765" ], "modifiers": [ [ "species_10590457", "catalyst" ] ], "additional_components": [ "DDB_G0274339" ] }, "reaction_10600093": { "compartment": "compartment_12045", "id": "reaction_10600093", "reactome": "R-DDI-2046100", "name": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046059", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2046057", "species_162743", "species_159751" ], "modifiers": [ [ "species_10593964", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10600076": { "compartment": "compartment_12045", "id": "reaction_10600076", "reactome": "R-DDI-2046085", "name": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211579", "species_2046056", "species_162743" ], "products": [ "species_2046064", "species_2046049", "species_2046062" ], "modifiers": [ [ "species_10600073", "catalyst" ] ], "additional_components": [ "species_29926", "Q54JK0", "DDB_G0288001", "Q55DR6", "DDB_G0269242", "Q1ZXQ4", "DDB_G0269474" ] }, "reaction_10600079": { "compartment": "compartment_17957", "id": "reaction_10600079", "reactome": "R-DDI-2046087", "name": "Translocation of tetracosahexaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046054", "species_211579" ], "products": [ "species_426639", "species_211606", "species_2046047" ], "modifiers": [ [ "species_10590195", "catalyst" ] ], "additional_components": [ "DDB_G0293194" ] }, "reaction_10578260": { "compartment": "compartment_5460", "id": "reaction_10578260", "reactome": "R-DDI-71020", "name": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71019" ], "products": [ "species_71009" ], "modifiers": [ [ "species_10578257", "catalyst" ] ], "additional_components": [ "DDB_G0275181" ] }, "reaction_10578278": { "compartment": "compartment_5460", "id": "reaction_10578278", "reactome": "R-DDI-71031", "name": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70843", "species_113593", "species_29376" ], "products": [ "species_113548", "species_113581", "species_71019" ], "modifiers": [ [ "species_10578275", "catalyst" ] ], "additional_components": [ "Q553S7", "DDB_G0275355", "Q8T131", "DDB_G0276341" ] }, "reaction_10582422": { "compartment": "compartment_5460", "id": "reaction_10582422", "reactome": "R-DDI-77256", "name": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77255", "species_113521" ], "products": [ "species_77252" ], "modifiers": [ [ "species_10578064", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10582424": { "compartment": "compartment_5460", "id": "reaction_10582424", "reactome": "R-DDI-77314", "name": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77313", "species_113521" ], "products": [ "species_77251" ], "modifiers": [ [ "species_10578064", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10582428": { "compartment": "compartment_5460", "id": "reaction_10582428", "reactome": "R-DDI-77333", "name": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77332", "species_113521" ], "products": [ "species_77330" ], "modifiers": [ [ "species_10578064", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10582426": { "compartment": "compartment_5460", "id": "reaction_10582426", "reactome": "R-DDI-77325", "name": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77324", "species_113521" ], "products": [ "species_77322" ], "modifiers": [ [ "species_10578064", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10611862": { "compartment": "compartment_5460", "id": "reaction_10611862", "reactome": "R-DDI-5696004", "name": "ACSF2 ligates CoA-SH to MCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_5690531" ], "products": [ "species_159448", "species_159450", "species_5690542" ], "modifiers": [ [ "species_10611859", "catalyst" ] ], "additional_components": [ "DDB_G0284963" ] }, "reaction_10618485": { "compartment": "compartment_70101", "id": "reaction_10618485", "reactome": "R-DDI-8848250", "name": "ACBD6 binds LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164991", "species_10618481" ], "products": [ "species_10618483" ], "modifiers": [], "additional_components": [ "DDB_G0290237", "Q54GC8", "DDB_G0290237", "species_164991" ] }, "reaction_10622907": { "compartment": "compartment_70616", "id": "reaction_10622907", "reactome": "R-DDI-8933547", "name": "MCAT transfers Mal from Mal-CoA to NDUFAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_977314", "species_10622896" ], "products": [ "species_29374", "species_10622899" ], "modifiers": [ [ "species_10622904", "catalyst" ] ], "additional_components": [ "DDB_G0291866", "DDB_G0291866", "DDB_G0270558" ] }, "reaction_10610781": { "compartment": "compartment_5460", "id": "reaction_10610781", "reactome": "R-DDI-5690066", "name": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690540", "species_113521" ], "products": [ "species_29374", "species_5690519" ], "modifiers": [ [ "species_10610778", "catalyst" ] ], "additional_components": [ "species_164991", "species_5690542", "species_174602", "species_5690531", "Q54LP9", "DDB_G0286507", "Q556W3", "DDB_G0273293" ] }, "reaction_10610767": { "compartment": "compartment_70101", "id": "reaction_10610767", "reactome": "R-DDI-5690043", "name": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5690044" ], "products": [ "species_5690064", "species_76194" ], "modifiers": [ [ "species_10610764", "catalyst" ] ], "additional_components": [ "species_5690542", "species_164991", "species_5690531", "species_174602", "C7G041", "DDB_G0295733" ] }, "reaction_10618476": { "compartment": "compartment_17957", "id": "reaction_10618476", "reactome": "R-DDI-8848246", "name": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848288", "species_10618470" ], "products": [ "species_10618474" ], "modifiers": [], "additional_components": [ "species_164991", "species_5690542", "DDB_G0270658", "Q5FXM5", "DDB_G0270658", "species_164991", "species_5690542" ] }, "reaction_10587345": { "compartment": "compartment_70101", "id": "reaction_10587345", "reactome": "R-DDI-200423", "name": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10587333" ], "products": [ "species_10587340", "species_29370" ], "modifiers": [ [ "species_10587342", "catalyst" ] ], "additional_components": [ "Q54J08", "DDB_G0288387", "species_266099", "Q54J08", "DDB_G0288387", "species_266099", "Q54YF2", "DDB_G0277905", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542" ] }, "reaction_10581624": { "compartment": "compartment_70101", "id": "reaction_10581624", "reactome": "R-DDI-75851", "name": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_113592", "species_76183" ], "products": [ "species_29372", "species_29370", "species_29508" ], "modifiers": [ [ "species_10581621", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "Q54J08", "DDB_G0288387", "species_266099" ] }, "reaction_10622445": { "compartment": "compartment_70101", "id": "reaction_10622445", "reactome": "R-DDI-8876889", "name": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_113592", "species_76183" ], "products": [ "species_29372", "species_29370", "species_29508" ], "modifiers": [ [ "species_10587333", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "Q54J08", "DDB_G0288387", "species_266099" ] }, "reaction_10612737": { "compartment": "compartment_17951", "id": "reaction_10612737", "reactome": "R-DDI-6787811", "name": "HAO2 tetramer oxidises 2OH-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_6787810" ], "products": [ "species_113575", "species_6787814" ], "modifiers": [ [ "species_10612734", "catalyst" ] ], "additional_components": [ "Q54E41", "DDB_G0291814" ] }, "reaction_10590464": { "compartment": "compartment_17951", "id": "reaction_10590464", "reactome": "R-DDI-390252", "name": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_390249" ], "products": [ "species_390248" ], "modifiers": [ [ "species_10586623", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10595810": { "compartment": "compartment_17951", "id": "reaction_10595810", "reactome": "R-DDI-977317", "name": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_977323" ], "products": [ "species_353123", "species_389536" ], "modifiers": [ [ "species_10595807", "catalyst" ] ], "additional_components": [ "DDB_G0290089" ] }, "reaction_10590473": { "compartment": "compartment_17951", "id": "reaction_10590473", "reactome": "R-DDI-390256", "name": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_390260" ], "products": [ "species_390249", "species_113575" ], "modifiers": [ [ "species_10590470", "catalyst" ] ], "additional_components": [ "Q54GQ6", "DDB_G0289993", "species_113596" ] }, "reaction_10617416": { "compartment": "compartment_17951", "id": "reaction_10617416", "reactome": "R-DDI-6809808", "name": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6809801" ], "products": [ "species_6809800" ], "modifiers": [ [ "species_10617413", "catalyst" ] ], "additional_components": [ "Q5FXM5", "DDB_G0270658" ] }, "reaction_10590493": { "compartment": "compartment_17947", "id": "reaction_10590493", "reactome": "R-DDI-390393", "name": "Peroxisomal uptake of very long-chain fatty acyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390394" ], "products": [ "species_390260" ], "modifiers": [ [ "species_10590197", "catalyst" ] ], "additional_components": [ "Q8T8P3", "DDB_G0293194" ] }, "reaction_10590460": { "compartment": "compartment_17951", "id": "reaction_10590460", "reactome": "R-DDI-390250", "name": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193514", "species_390241" ], "products": [ "species_353123", "species_390246" ], "modifiers": [ [ "species_10590457", "catalyst" ] ], "additional_components": [ "DDB_G0274339" ] }, "reaction_10590462": { "compartment": "compartment_17951", "id": "reaction_10590462", "reactome": "R-DDI-390251", "name": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390248", "species_192307" ], "products": [ "species_193465", "species_390241", "species_192305" ], "modifiers": [ [ "species_10586623", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10617487": { "compartment": "compartment_17951", "id": "reaction_10617487", "reactome": "R-DDI-6810474", "name": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_6810523" ], "products": [ "species_6809360", "species_6810530" ], "modifiers": [ [ "species_10617484", "catalyst" ] ], "additional_components": [ "DDB_G0290277" ] }, "reaction_10590323": { "compartment": "compartment_17951", "id": "reaction_10590323", "reactome": "R-DDI-389639", "name": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389615", "species_389537" ], "products": [ "species_389594", "species_389583", "species_389536" ], "modifiers": [ [ "species_10590320", "catalyst" ] ], "additional_components": [ "species_71067", "Q54SF6", "DDB_G0282495" ] }, "reaction_10590313": { "compartment": "compartment_17951", "id": "reaction_10590313", "reactome": "R-DDI-389611", "name": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389594" ], "products": [ "species_389578", "species_389636" ], "modifiers": [ [ "species_10590310", "catalyst" ] ], "additional_components": [ "species_8878387", "species_29926", "Q54DA9", "DDB_G0292402" ] }, "reaction_10590331": { "compartment": "compartment_17947", "id": "reaction_10590331", "reactome": "R-DDI-389652", "name": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_389620" ], "products": [ "species_389573", "species_76577" ], "modifiers": [ [ "species_10590328", "catalyst" ] ], "additional_components": [ "DDB_G0272346" ] }, "reaction_10590301": { "compartment": "compartment_17951", "id": "reaction_10590301", "reactome": "R-DDI-389609", "name": "ALDH3A2-2 oxidizes pristanal to pristanate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389636", "species_192307" ], "products": [ "species_193465", "species_6811612", "species_192305" ], "modifiers": [ [ "species_10590298", "catalyst" ] ], "additional_components": [ "Q54DG1", "DDB_G0292270" ] }, "reaction_10589036": { "compartment": "compartment_70101", "id": "reaction_10589036", "reactome": "R-DDI-265296", "name": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29768" ], "products": [ "species_266010" ], "modifiers": [ [ "species_10589033", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "species_74112", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10600427": { "compartment": "compartment_70101", "id": "reaction_10600427", "reactome": "R-DDI-2161794", "name": "Arachidonic acid is converted to HXA3/B3 by ALOX12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29768" ], "products": [ "species_2162031" ], "modifiers": [ [ "species_10600421", "catalyst" ] ], "additional_components": [ "species_8942209", "CHEBI:34784", "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10600435": { "compartment": "compartment_12045", "id": "reaction_10600435", "reactome": "R-DDI-2161890", "name": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29768", "species_29364" ], "products": [ "species_29356", "species_29366", "species_2142739" ], "modifiers": [ [ "species_10582322", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10600471": { "compartment": "compartment_70101", "id": "reaction_10600471", "reactome": "R-DDI-2161961", "name": "EET(1) is hydrolysed to DHET(1) by EPHX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2161818" ], "products": [ "species_2161883" ], "modifiers": [ [ "species_10600468", "catalyst" ] ], "additional_components": [ "species_2142739", "CHEBI:34130", "CHEBI:34490", "CHEBI:34157", "CHEBI:63974", "CHEBI:63969", "CHEBI:63970", "CHEBI:63966", "Q54T91", "DDB_G0281917", "species_29926" ] }, "reaction_10600440": { "compartment": "compartment_12045", "id": "reaction_10600440", "reactome": "R-DDI-2161899", "name": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29768", "species_29364" ], "products": [ "species_29356", "species_2161753", "species_29366" ], "modifiers": [ [ "species_10600437", "catalyst" ] ], "additional_components": [ "CHEBI:34130", "CHEBI:34490", "CHEBI:34157", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10600432": { "compartment": "compartment_12045", "id": "reaction_10600432", "reactome": "R-DDI-2161814", "name": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2142836" ], "modifiers": [ [ "species_10600429", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10600447": { "compartment": "compartment_12045", "id": "reaction_10600447", "reactome": "R-DDI-2161940", "name": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2142780" ], "modifiers": [ [ "species_10588851", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10589155": { "compartment": "compartment_70101", "id": "reaction_10589155", "reactome": "R-DDI-266072", "name": "LTA4 is hydolysed to LTB4 by LTA4H", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_265281" ], "products": [ "species_266056" ], "modifiers": [ [ "species_10589152", "catalyst" ] ], "additional_components": [ "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10600500": { "compartment": "compartment_70101", "id": "reaction_10600500", "reactome": "R-DDI-2162019", "name": "LTA4 is converted to EXA4 by ALOX15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265281" ], "products": [ "species_2142772" ], "modifiers": [ [ "species_10600479", "catalyst" ] ], "additional_components": [ "species_71067", "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577" ] }, "reaction_10589113": { "compartment": "compartment_70101", "id": "reaction_10589113", "reactome": "R-DDI-266050", "name": "LTA4 is converted to LTC4 by LTC4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_265281" ], "products": [ "species_266066" ], "modifiers": [ [ "species_10589033", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "species_74112", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10589145": { "compartment": "compartment_876", "id": "reaction_10589145", "reactome": "R-DDI-266070", "name": "LTC4 is exported from the cytosol by ABCC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266066" ], "products": [ "species_266013" ], "modifiers": [ [ "species_10589142", "catalyst" ] ], "additional_components": [ "Q54JR2", "DDB_G0287691", "Q54LE6", "DDB_G0286559", "Q8ST87", "DDB_G0280977", "Q54P13", "DDB_G0284867", "Q54U44", "DDB_G0280973" ] }, "reaction_10589115": { "compartment": "compartment_70101", "id": "reaction_10589115", "reactome": "R-DDI-266051", "name": "5S-HpETE is dehydrated to LTA4 by ALOX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266010" ], "products": [ "species_29356", "species_265281" ], "modifiers": [ [ "species_10589033", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "species_74112", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10600410": { "compartment": "compartment_70101", "id": "reaction_10600410", "reactome": "R-DDI-2161768", "name": "EXA4 is converted to EXC4 by LTC4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_2142772" ], "products": [ "species_2142726" ], "modifiers": [ [ "species_10589033", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "species_74112", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10600497": { "compartment": "compartment_70101", "id": "reaction_10600497", "reactome": "R-DDI-2162002", "name": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29768" ], "products": [ "species_2142718" ], "modifiers": [ [ "species_10600494", "catalyst" ] ], "additional_components": [ "species_71067", "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577" ] }, "reaction_10623250": { "compartment": "compartment_70101", "id": "reaction_10623250", "reactome": "R-DDI-8942208", "name": "ALOXE3 isomerises 12R-HpETE to HXA3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142790" ], "products": [ "species_8942209" ], "modifiers": [ [ "species_10623247", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577" ] }, "reaction_10600450": { "compartment": "compartment_70101", "id": "reaction_10600450", "reactome": "R-DDI-2161948", "name": "Arachidonic acid is converted to 12-oxoETE by ALOX12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29768" ], "products": [ "species_2142745" ], "modifiers": [ [ "species_10600421", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10600484": { "compartment": "compartment_70101", "id": "reaction_10600484", "reactome": "R-DDI-2161964", "name": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29768" ], "products": [ "species_2142811" ], "modifiers": [ [ "species_10600481", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10600461": { "compartment": "compartment_70101", "id": "reaction_10600461", "reactome": "R-DDI-2161950", "name": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29768" ], "products": [ "species_2142790" ], "modifiers": [ [ "species_10600458", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577", "species_71067" ] }, "reaction_10594017": { "compartment": "compartment_70101", "id": "reaction_10594017", "reactome": "R-DDI-549192", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_76103" ], "products": [ "species_549167", "species_76194" ], "modifiers": [ [ "species_10594014", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10611920": { "compartment": "compartment_12045", "id": "reaction_10611920", "reactome": "R-DDI-5696119", "name": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_5696122", "species_29368" ], "products": [ "species_29356", "species_1497857", "species_76116", "species_5696116" ], "modifiers": [ [ "species_10611917", "catalyst" ] ], "additional_components": [ "DDB_G0277137" ] }, "reaction_10581764": { "compartment": "compartment_70101", "id": "reaction_10581764", "reactome": "R-DDI-75900", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_76103" ], "products": [ "species_549167", "species_76194" ], "modifiers": [ [ "species_10581761", "catalyst" ] ], "additional_components": [ "Q55BH9", "DDB_G0271342" ] }, "reaction_10581736": { "compartment": "compartment_70101", "id": "reaction_10581736", "reactome": "R-DDI-75887", "name": "Conversion of Glycerol to Glycerol-3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76116" ], "products": [ "species_29370", "species_76114" ], "modifiers": [ [ "species_10581731", "catalyst" ] ], "additional_components": [ "DDB_G0280371" ] }, "reaction_10616072": { "compartment": "compartment_12045", "id": "reaction_10616072", "reactome": "R-DDI-6800334", "name": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6800352", "species_1500578" ], "products": [ "species_76103", "species_76194" ], "modifiers": [ [ "species_10616065", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10581754": { "compartment": "compartment_70101", "id": "reaction_10581754", "reactome": "R-DDI-75899", "name": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76108", "species_29356" ], "products": [ "species_29372", "species_76103" ], "modifiers": [ [ "species_10581751", "catalyst" ] ], "additional_components": [ "Q75JA1", "DDB_G0271730" ] }, "reaction_10625442": { "compartment": "compartment_70101", "id": "reaction_10625442", "reactome": "R-DDI-9018862", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9022655" ], "products": [ "species_9022660" ], "modifiers": [ [ "species_10589152", "catalyst" ] ], "additional_components": [ "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10625439": { "compartment": "compartment_70101", "id": "reaction_10625439", "reactome": "R-DDI-9018859", "name": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9020602" ], "products": [ "species_9022655" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625485": { "compartment": "compartment_70101", "id": "reaction_10625485", "reactome": "R-DDI-9020610", "name": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9020474" ], "products": [ "species_9022679" ], "modifiers": [ [ "species_10600477", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577" ] }, "reaction_10625437": { "compartment": "compartment_70101", "id": "reaction_10625437", "reactome": "R-DDI-9018858", "name": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9020474" ], "products": [ "species_9020602" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625446": { "compartment": "compartment_70101", "id": "reaction_10625446", "reactome": "R-DDI-9018877", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9023708" ], "products": [ "species_9023712" ], "modifiers": [ [ "species_10589152", "catalyst" ] ], "additional_components": [ "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10625444": { "compartment": "compartment_70101", "id": "reaction_10625444", "reactome": "R-DDI-9018863", "name": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023651", "species_29368" ], "products": [ "species_9023702" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625451": { "compartment": "compartment_70101", "id": "reaction_10625451", "reactome": "R-DDI-9018907", "name": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023651", "species_29368" ], "products": [ "species_9023644" ], "modifiers": [ [ "species_10600477", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577" ] }, "reaction_10625448": { "compartment": "compartment_70101", "id": "reaction_10625448", "reactome": "R-DDI-9018894", "name": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023702", "species_29368" ], "products": [ "species_9023708" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625505": { "compartment": "compartment_70101", "id": "reaction_10625505", "reactome": "R-DDI-9025957", "name": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9025155", "species_29368" ], "products": [ "species_9025960" ], "modifiers": [ [ "species_10600421", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10625503": { "compartment": "compartment_70101", "id": "reaction_10625503", "reactome": "R-DDI-9025152", "name": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9025155", "species_29368" ], "products": [ "species_9025151" ], "modifiers": [ [ "species_10600477", "catalyst" ] ], "additional_components": [ "CHEBI:138674", "CHEBI:138673", "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577" ] }, "reaction_10625507": { "compartment": "compartment_70101", "id": "reaction_10625507", "reactome": "R-DDI-9025995", "name": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9026034", "species_29366" ], "products": [ "species_9026050", "species_29364" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625511": { "compartment": "compartment_70101", "id": "reaction_10625511", "reactome": "R-DDI-9025999", "name": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9026047" ], "products": [ "species_9026046", "species_29364" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625509": { "compartment": "compartment_70101", "id": "reaction_10625509", "reactome": "R-DDI-9025996", "name": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9026047" ], "products": [ "species_9026034" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625513": { "compartment": "compartment_70101", "id": "reaction_10625513", "reactome": "R-DDI-9026003", "name": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9608444", "species_29368" ], "products": [ "species_9026047" ], "modifiers": [ [ "species_10600477", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577" ] }, "reaction_10625521": { "compartment": "compartment_70101", "id": "reaction_10625521", "reactome": "R-DDI-9026405", "name": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9026400", "species_29368" ], "products": [ "species_9026394" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "CHEBI:137020", "CHEBI:137011", "CHEBI:137018", "CHEBI:137019", "DDB_G0279909" ] }, "reaction_10625547": { "compartment": "compartment_70101", "id": "reaction_10625547", "reactome": "R-DDI-9027628", "name": "ALOX5 oxidises EPA to 5-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2026977", "species_29368" ], "products": [ "species_9028283" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625545": { "compartment": "compartment_70101", "id": "reaction_10625545", "reactome": "R-DDI-9027624", "name": "ALOX5 oxidises DHA to 7-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024011" ], "products": [ "species_9028274" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625549": { "compartment": "compartment_70101", "id": "reaction_10625549", "reactome": "R-DDI-9027633", "name": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9608444", "species_29368" ], "products": [ "species_9028240" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10600424": { "compartment": "compartment_70101", "id": "reaction_10600424", "reactome": "R-DDI-2161775", "name": "ALOX12 oxidises LTA4 to LXA4/B4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9032038", "species_29368" ], "products": [ "species_2161856" ], "modifiers": [ [ "species_10600421", "catalyst" ] ], "additional_components": [ "CHEBI:6499", "CHEBI:6498", "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10600443": { "compartment": "compartment_70101", "id": "reaction_10600443", "reactome": "R-DDI-2161907", "name": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_2142738" ], "products": [ "species_2161609" ], "modifiers": [ [ "species_10589033", "catalyst" ] ], "additional_components": [ "CHEBI:63991", "CHEBI:63990", "Q54W35", "DDB_G0279909", "species_74112", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10600445": { "compartment": "compartment_70101", "id": "reaction_10600445", "reactome": "R-DDI-2161917", "name": "ALOX5 oxidises 15S-HpETE to LXA4/B4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142718", "species_29368" ], "products": [ "species_2161856" ], "modifiers": [ [ "species_10589033", "catalyst" ] ], "additional_components": [ "CHEBI:6499", "CHEBI:6498", "Q54W35", "DDB_G0279909", "species_74112", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10625475": { "compartment": "compartment_70101", "id": "reaction_10625475", "reactome": "R-DDI-9020274", "name": "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024011" ], "products": [ "species_9025012" ], "modifiers": [ [ "species_10600421", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10625473": { "compartment": "compartment_70101", "id": "reaction_10625473", "reactome": "R-DDI-9020270", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024577" ], "products": [ "species_9024570" ], "modifiers": [ [ "species_10589152", "catalyst" ] ], "additional_components": [ "CHEBI:138615", "CHEBI:138616", "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10625461": { "compartment": "compartment_70101", "id": "reaction_10625461", "reactome": "R-DDI-9020256", "name": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024479" ], "products": [ "species_29364", "species_9024602" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625467": { "compartment": "compartment_70101", "id": "reaction_10625467", "reactome": "R-DDI-9020259", "name": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024463" ], "products": [ "species_9024576" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625481": { "compartment": "compartment_70101", "id": "reaction_10625481", "reactome": "R-DDI-9020278", "name": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024576", "species_29366" ], "products": [ "species_9024577", "species_29364" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625455": { "compartment": "compartment_70101", "id": "reaction_10625455", "reactome": "R-DDI-9020252", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024602" ], "products": [ "species_9024574" ], "modifiers": [ [ "species_10589152", "catalyst" ] ], "additional_components": [ "CHEBI:138179", "CHEBI:138614", "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10625453": { "compartment": "compartment_70101", "id": "reaction_10625453", "reactome": "R-DDI-9020251", "name": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024463" ], "products": [ "species_9024479" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625477": { "compartment": "compartment_70101", "id": "reaction_10625477", "reactome": "R-DDI-9020275", "name": "ALOX15 oxidises DHA to 17(S)-Hp-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024011" ], "products": [ "species_9024012" ], "modifiers": [ [ "species_10600477", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577" ] }, "reaction_10625493": { "compartment": "compartment_70101", "id": "reaction_10625493", "reactome": "R-DDI-9024881", "name": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024012" ], "products": [ "species_29364", "species_9024873" ], "modifiers": [ [ "species_10600477", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577" ] }, "reaction_10625459": { "compartment": "compartment_70101", "id": "reaction_10625459", "reactome": "R-DDI-9020255", "name": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024765" ], "products": [ "species_9024768", "species_29364" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625457": { "compartment": "compartment_70101", "id": "reaction_10625457", "reactome": "R-DDI-9020253", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024781" ], "products": [ "species_9024809" ], "modifiers": [ [ "species_10589152", "catalyst" ] ], "additional_components": [ "CHEBI:138649", "CHEBI:138648", "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10625479": { "compartment": "compartment_70101", "id": "reaction_10625479", "reactome": "R-DDI-9020277", "name": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024797" ], "products": [ "species_29364", "species_9024781" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625483": { "compartment": "compartment_70101", "id": "reaction_10625483", "reactome": "R-DDI-9020282", "name": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024815" ], "products": [ "species_9024765" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625465": { "compartment": "compartment_70101", "id": "reaction_10625465", "reactome": "R-DDI-9020258", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024768" ], "products": [ "species_9024759" ], "modifiers": [ [ "species_10589152", "catalyst" ] ], "additional_components": [ "CHEBI:81565", "CHEBI:81564", "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10625471": { "compartment": "compartment_70101", "id": "reaction_10625471", "reactome": "R-DDI-9020264", "name": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024815" ], "products": [ "species_9024797" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625497": { "compartment": "compartment_70101", "id": "reaction_10625497", "reactome": "R-DDI-9024983", "name": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9025012", "species_29366" ], "products": [ "species_29364", "species_9025001" ], "modifiers": [ [ "species_10600421", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10625538": { "compartment": "compartment_70101", "id": "reaction_10625538", "reactome": "R-DDI-9027043", "name": "CYPs hydroxylate DHA to 14(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_9024011" ], "products": [ "species_29356", "species_29366", "species_9027049" ], "modifiers": [ [ "species_10625535", "catalyst" ] ], "additional_components": [ "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778" ] }, "reaction_10625543": { "compartment": "compartment_70101", "id": "reaction_10625543", "reactome": "R-DDI-9027321", "name": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_9027049" ], "products": [ "species_29356", "species_29366", "species_9027324" ], "modifiers": [ [ "species_10582018", "catalyst" ] ], "additional_components": [ "CHEBI:137368", "CHEBI:137361", "Q1ZXF5", "DDB_G0284535", "Q86A22", "DDB_G0272704", "Q54SK0", "DDB_G0282419", "Q54LA8", "DDB_G0286743", "Q54SV9", "DDB_G0282283", "Q1ZXG3", "DDB_G0282769", "Q54LT7", "DDB_G0286419", "Q1ZXL2", "DDB_G0275197", "Q54ZM4", "DDB_G0277545", "Q54NY3", "DDB_G0284923", "Q556M4", "DDB_G0272604", "Q1ZXL7", "DDB_G0273047", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54CS3", "DDB_G0292792", "Q1ZXA4", "DDB_G0292790", "Q556M5", "DDB_G0273045", "Q54QD0", "DDB_G0283933", "Q55AJ4", "DDB_G0271778", "Q54DT2", "DDB_G0292168", "Q54QD2", "DDB_G0283929", "Q1ZXF3", "DDB_G0284647", "Q54EM5", "DDB_G0291448" ] }, "reaction_10625541": { "compartment": "compartment_70101", "id": "reaction_10625541", "reactome": "R-DDI-9027302", "name": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9027029", "species_70106", "species_29368", "species_29364" ], "products": [ "species_29356", "species_9027326", "species_29366" ], "modifiers": [ [ "species_10582018", "catalyst" ] ], "additional_components": [ "CHEBI:137360", "CHEBI:137354", "Q1ZXF5", "DDB_G0284535", "Q86A22", "DDB_G0272704", "Q54SK0", "DDB_G0282419", "Q54LA8", "DDB_G0286743", "Q54SV9", "DDB_G0282283", "Q1ZXG3", "DDB_G0282769", "Q54LT7", "DDB_G0286419", "Q1ZXL2", "DDB_G0275197", "Q54ZM4", "DDB_G0277545", "Q54NY3", "DDB_G0284923", "Q556M4", "DDB_G0272604", "Q1ZXL7", "DDB_G0273047", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54CS3", "DDB_G0292792", "Q1ZXA4", "DDB_G0292790", "Q556M5", "DDB_G0273045", "Q54QD0", "DDB_G0283933", "Q55AJ4", "DDB_G0271778", "Q54DT2", "DDB_G0292168", "Q54QD2", "DDB_G0283929", "Q1ZXF3", "DDB_G0284647", "Q54EM5", "DDB_G0291448" ] }, "reaction_10625499": { "compartment": "compartment_70101", "id": "reaction_10625499", "reactome": "R-DDI-9024993", "name": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_9025001" ], "products": [ "species_9025011" ], "modifiers": [ [ "species_10600468", "catalyst" ] ], "additional_components": [ "Q54T91", "DDB_G0281917", "species_29926" ] }, "reaction_10625501": { "compartment": "compartment_70101", "id": "reaction_10625501", "reactome": "R-DDI-9024997", "name": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9025012", "species_29368" ], "products": [ "species_9024989" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625533": { "compartment": "compartment_70101", "id": "reaction_10625533", "reactome": "R-DDI-9026911", "name": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9024768" ], "products": [ "species_9026915" ], "modifiers": [ [ "species_10625528", "catalyst" ] ], "additional_components": [ "Q54GA9", "DDB_G0290291" ] }, "reaction_10625524": { "compartment": "compartment_70101", "id": "reaction_10625524", "reactome": "R-DDI-9026777", "name": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9025001" ], "products": [ "species_9026761" ], "modifiers": [ [ "species_10585637", "catalyst" ] ], "additional_components": [ "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q54VI4", "DDB_G0280317", "Q556G3", "DDB_G0272632", "Q556P3", "DDB_G0273153", "Q55FF3", "DDB_G0268138" ] }, "reaction_10625531": { "compartment": "compartment_70101", "id": "reaction_10625531", "reactome": "R-DDI-9026780", "name": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9025001" ], "products": [ "species_9026761" ], "modifiers": [ [ "species_10625528", "catalyst" ] ], "additional_components": [ "Q54GA9", "DDB_G0290291" ] }, "reaction_10625491": { "compartment": "compartment_70101", "id": "reaction_10625491", "reactome": "R-DDI-9024872", "name": "ALOX15 oxidises 17(S)-Hp-DHA to PDX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024012" ], "products": [ "species_9024883" ], "modifiers": [ [ "species_10600477", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577" ] }, "reaction_10625495": { "compartment": "compartment_70101", "id": "reaction_10625495", "reactome": "R-DDI-9024890", "name": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024873" ], "products": [ "species_9024886" ], "modifiers": [ [ "species_10589152", "catalyst" ] ], "additional_components": [ "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10625463": { "compartment": "compartment_70101", "id": "reaction_10625463", "reactome": "R-DDI-9020257", "name": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024893" ], "products": [ "species_9024879" ], "modifiers": [ [ "species_10589152", "catalyst" ] ], "additional_components": [ "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10625469": { "compartment": "compartment_70101", "id": "reaction_10625469", "reactome": "R-DDI-9020262", "name": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024522" ], "products": [ "species_29364", "species_9024893" ], "modifiers": [ [ "species_10600477", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577" ] }, "reaction_10591619": { "compartment": "compartment_70101", "id": "reaction_10591619", "reactome": "R-DDI-428214", "name": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428163" ], "products": [ "species_29370", "species_428275" ], "modifiers": [ [ "species_10591616", "catalyst" ] ], "additional_components": [ "Q6B516", "DDB_G0284545", "Q54HN2", "DDB_G0289343", "Q86KF9", "DDB_G0272522" ] }, "reaction_10591683": { "compartment": "compartment_70101", "id": "reaction_10591683", "reactome": "R-DDI-428676", "name": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203" ], "products": [ "species_428671", "species_428686" ], "modifiers": [ [ "species_10591680", "catalyst" ] ], "additional_components": [ "DDB_G0282819" ] }, "reaction_10611267": { "compartment": "compartment_12045", "id": "reaction_10611267", "reactome": "R-DDI-5692261", "name": "ALDH3A2-1 oxidises HD2NAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428671", "species_29360" ], "products": [ "species_70106", "species_3632881", "species_73473" ], "modifiers": [ [ "species_10611264", "catalyst" ] ], "additional_components": [ "Q54DG1", "DDB_G0292270" ] }, "reaction_10591685": { "compartment": "compartment_70101", "id": "reaction_10591685", "reactome": "R-DDI-428681", "name": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428275" ], "products": [ "species_428686", "species_428663" ], "modifiers": [ [ "species_10591680", "catalyst" ] ], "additional_components": [ "DDB_G0282819" ] }, "reaction_10624103": { "compartment": "compartment_12045", "id": "reaction_10624103", "reactome": "R-DDI-8959462", "name": "SAMD8 transforms PE and CERA to CPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8959490", "species_8959486" ], "products": [ "species_8959463" ], "modifiers": [ [ "species_10624100", "catalyst" ] ], "additional_components": [ "DDB_G0293880" ] }, "reaction_10591627": { "compartment": "compartment_70101", "id": "reaction_10591627", "reactome": "R-DDI-428259", "name": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_428206", "species_428126", "species_29368" ], "products": [ "species_428218", "species_29356", "species_428256" ], "modifiers": [ [ "species_10591624", "catalyst" ] ], "additional_components": [ "species_192305", "species_29364", "species_29360", "species_29366", "DDB_G0269738" ] }, "reaction_10591819": { "compartment": "compartment_876", "id": "reaction_10591819", "reactome": "R-DDI-429786", "name": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429802", "species_429807" ], "products": [ "species_429776", "species_112275" ], "modifiers": [ [ "species_10591816", "catalyst" ] ], "additional_components": [ "DDB_G0293880" ] }, "reaction_10611887": { "compartment": "compartment_876", "id": "reaction_10611887", "reactome": "R-DDI-5696080", "name": "ALDH3B1 oxidises HXAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428663", "species_29360" ], "products": [ "species_70106", "species_3632881", "species_73473" ], "modifiers": [ [ "species_10611884", "catalyst" ] ], "additional_components": [ "DDB_G0292270" ] }, "reaction_10591630": { "compartment": "compartment_70101", "id": "reaction_10591630", "reactome": "R-DDI-428260", "name": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_428126", "species_29368", "species_29364" ], "products": [ "species_29356", "species_29366", "species_9025544" ], "modifiers": [ [ "species_10591624", "catalyst" ] ], "additional_components": [ "DDB_G0269738" ] }, "reaction_10591726": { "compartment": "compartment_70101", "id": "reaction_10591726", "reactome": "R-DDI-428696", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203", "species_29356" ], "products": [ "species_428682", "species_29372" ], "modifiers": [ [ "species_10591723", "catalyst" ] ], "additional_components": [ "Q54PR7", "DDB_G0284367", "Q86AF0", "DDB_G0284367", "Q8MXL9", "DDB_G0284367" ] }, "reaction_10591729": { "compartment": "compartment_70101", "id": "reaction_10591729", "reactome": "R-DDI-428701", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203", "species_29356" ], "products": [ "species_428682", "species_29372" ], "modifiers": [ [ "species_10591669", "catalyst" ] ], "additional_components": [ "DDB_G0272260" ] }, "reaction_10591824": { "compartment": "compartment_20699", "id": "reaction_10591824", "reactome": "R-DDI-429798", "name": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429785", "species_428270" ], "products": [ "species_429773", "species_429789" ], "modifiers": [ [ "species_10591821", "catalyst" ] ], "additional_components": [ "DDB_G0293880" ] }, "reaction_10591600": { "compartment": "compartment_70101", "id": "reaction_10591600", "reactome": "R-DDI-428185", "name": "sphinganine + stearyl-CoA => dihydroceramide + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428139", "species_428163" ], "products": [ "species_428126", "species_76194" ], "modifiers": [ [ "species_10591587", "catalyst" ] ], "additional_components": [ "DDB_G0282607" ] }, "reaction_10616950": { "compartment": "compartment_13977", "id": "reaction_10616950", "reactome": "R-DDI-6808464", "name": "ALDH3B2 oxidises HXAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6808468", "species_29360" ], "products": [ "species_2453691", "species_70106", "species_73473" ], "modifiers": [ [ "species_10616947", "catalyst" ] ], "additional_components": [ "DDB_G0292270" ] }, "reaction_10591638": { "compartment": "compartment_70101", "id": "reaction_10591638", "reactome": "R-DDI-428262", "name": "phytoceramide + H2O => stearate + phytosphingosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9025544" ], "products": [ "species_428237", "species_3632878" ], "modifiers": [ [ "species_10591635", "catalyst" ] ], "additional_components": [ "DDB_G0288359" ] }, "reaction_10591641": { "compartment": "compartment_70101", "id": "reaction_10591641", "reactome": "R-DDI-428273", "name": "SPHK1 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428193" ], "products": [ "species_428203", "species_29370" ], "modifiers": [ [ "species_10590508", "catalyst" ] ], "additional_components": [ "DDB_G0284545" ] }, "reaction_10591705": { "compartment": "compartment_984", "id": "reaction_10591705", "reactome": "R-DDI-428690", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_419305", "species_109276" ], "products": [ "species_109277", "species_428662" ], "modifiers": [ [ "species_10591702", "catalyst" ] ], "additional_components": [ "Q8MXL9", "DDB_G0284367", "Q54PR7", "DDB_G0284367", "Q86AF0", "DDB_G0284367" ] }, "reaction_10591674": { "compartment": "compartment_70101", "id": "reaction_10591674", "reactome": "R-DDI-428664", "name": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428275" ], "products": [ "species_29372", "species_428694" ], "modifiers": [ [ "species_10591669", "catalyst" ] ], "additional_components": [ "DDB_G0272260" ] }, "reaction_10611452": { "compartment": "compartment_12045", "id": "reaction_10611452", "reactome": "R-DDI-5693761", "name": "FA2H hydroxylates CERA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_428256" ], "products": [ "species_5693768", "species_29356" ], "modifiers": [ [ "species_10611449", "catalyst" ] ], "additional_components": [ "DDB_G0269908" ] }, "reaction_10627391": { "compartment": "compartment_70101", "id": "reaction_10627391", "reactome": "R-DDI-9695949", "name": "SPHK2 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428193" ], "products": [ "species_428203", "species_29370" ], "modifiers": [ [ "species_10591614", "catalyst" ], [ "species_10627389", "inhibitor" ] ], "additional_components": [ "Q54HN2", "DDB_G0289343", "Q6B516", "DDB_G0284545", "Q86KF9", "DDB_G0272522", "Q54HN2", "DDB_G0289343", "Q6B516", "DDB_G0284545", "Q86KF9", "DDB_G0272522" ] }, "reaction_10591582": { "compartment": "compartment_70101", "id": "reaction_10591582", "reactome": "R-DDI-428123", "name": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_428182" ], "products": [ "species_29366", "species_428163" ], "modifiers": [ [ "species_10591579", "catalyst" ] ], "additional_components": [ "DDB_G0289061" ] }, "reaction_10586816": { "compartment": "compartment_70101", "id": "reaction_10586816", "reactome": "R-DDI-196761", "name": "2xTPK1:Mg2+ phosphorylates THMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196934" ], "products": [ "species_29480", "species_76577" ], "modifiers": [ [ "species_10586813", "catalyst" ] ], "additional_components": [ "species_29926", "Q55GR8", "DDB_G0267546" ] }, "reaction_10587239": { "compartment": "compartment_876", "id": "reaction_10587239", "reactome": "R-DDI-199626", "name": "SLC19A2/3 transport extracellular THMN to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199622" ], "products": [ "species_196934" ], "modifiers": [ [ "species_10587236", "catalyst" ] ], "additional_components": [ "Q559K0", "DDB_G0272544" ] }, "reaction_10622123": { "compartment": "compartment_17927", "id": "reaction_10622123", "reactome": "R-DDI-8875838", "name": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29480" ], "products": [ "species_8878387" ], "modifiers": [ [ "species_10622120", "catalyst" ] ], "additional_components": [ "DDB_G0280161" ] }, "reaction_10587154": { "compartment": "compartment_876", "id": "reaction_10587154", "reactome": "R-DDI-198818", "name": "SLC2A1,3 transports DeHA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198852" ], "products": [ "species_198827" ], "modifiers": [ [ "species_10587151", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10587173": { "compartment": "compartment_70101", "id": "reaction_10587173", "reactome": "R-DDI-198845", "name": "CYB5A:heme reduces Asc.- to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1497805", "species_10587170" ], "products": [ "species_198816", "species_10587168" ], "modifiers": [ [ "species_10587170", "catalyst" ] ], "additional_components": [ "species_917877", "Q54XT7", "DDB_G0278753", "Q86L22", "DDB_G0277079", "CHEBI:36144", "Q54XT7", "DDB_G0278753", "Q86L22", "DDB_G0277079", "species_917877", "Q54XT7", "DDB_G0278753", "Q86L22", "DDB_G0277079" ] }, "reaction_10587189": { "compartment": "compartment_70101", "id": "reaction_10587189", "reactome": "R-DDI-199202", "name": "Phosphopantetheine conjugation of the ACP domain of FAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587181", "species_76194" ], "products": [ "species_10581670", "species_158466" ], "modifiers": [ [ "species_10587186", "catalyst" ] ], "additional_components": [ "Q55E72", "DDB_G0269364", "Q869W9", "DDB_G0275069", "Q869X2", "DDB_G0275077", "Q869X2", "DDB_G0275077", "Q55E72", "DDB_G0269364", "Q869W9", "DDB_G0275069", "DDB_G0285927" ] }, "reaction_10623045": { "compartment": "compartment_70101", "id": "reaction_10623045", "reactome": "R-DDI-8938300", "name": "Vanin hydrolyses pantetheine to PanK, 2AET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8938313" ], "products": [ "species_196820", "species_6814151" ], "modifiers": [ [ "species_10623042", "catalyst" ] ], "additional_components": [ "Q54WG1", "DDB_G0279675" ] }, "reaction_10586819": { "compartment": "compartment_70101", "id": "reaction_10586819", "reactome": "R-DDI-196773", "name": "COASY phosphorylates DP-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196778" ], "products": [ "species_29370", "species_76194" ], "modifiers": [ [ "species_10586803", "catalyst" ] ], "additional_components": [ "DDB_G0288465" ] }, "reaction_10586806": { "compartment": "compartment_70101", "id": "reaction_10586806", "reactome": "R-DDI-196754", "name": "COASY transfers an adenylyl group from ATP to PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196767", "species_113592" ], "products": [ "species_111294", "species_196778" ], "modifiers": [ [ "species_10586803", "catalyst" ] ], "additional_components": [ "DDB_G0288465" ] }, "reaction_10586829": { "compartment": "compartment_70101", "id": "reaction_10586829", "reactome": "R-DDI-196840", "name": "3xPPCDC:3FMN decarboxylates PPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196834" ], "products": [ "species_196767", "species_113528" ], "modifiers": [ [ "species_10586826", "catalyst" ] ], "additional_components": [ "species_76629", "Q54Y51", "DDB_G0278413" ] }, "reaction_10587197": { "compartment": "compartment_70616", "id": "reaction_10587197", "reactome": "R-DDI-199216", "name": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194" ], "products": [ "species_29374" ], "modifiers": [ [ "species_10587194", "catalyst" ] ], "additional_components": [ "DDB_G0292034" ] }, "reaction_10586798": { "compartment": "compartment_70101", "id": "reaction_10586798", "reactome": "R-DDI-196753", "name": "2xPPCS ligates PPanK with Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_113592", "species_196786" ], "products": [ "species_111294", "species_196834", "species_76577" ], "modifiers": [ [ "species_10586795", "catalyst" ] ], "additional_components": [ "Q54S85", "DDB_G0282611" ] }, "reaction_10595303": { "compartment": "compartment_70101", "id": "reaction_10595303", "reactome": "R-DDI-947499", "name": "Exchange of oxygen with sulfur in MoCo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_947539", "species_111707" ], "products": [ "species_947575", "species_29432" ], "modifiers": [ [ "species_10595300", "catalyst" ] ], "additional_components": [ "DDB_G0272935" ] }, "reaction_10595350": { "compartment": "compartment_70101", "id": "reaction_10595350", "reactome": "R-DDI-947535", "name": "Cyclisation of GTP to precursor Z", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29356", "species_71284" ], "products": [ "species_111294", "species_947537", "species_947703", "species_174390" ], "modifiers": [ [ "species_10595347", "catalyst" ] ], "additional_components": [ "Q54NM6", "DDB_G0285137", "CHEBI:33722" ] }, "reaction_10595338": { "compartment": "compartment_70101", "id": "reaction_10595338", "reactome": "R-DDI-947531", "name": "Molybdenum ion transfer onto molybdopterin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_947561", "species_947496" ], "products": [ "species_111294", "species_947539", "species_76577" ], "modifiers": [ [ "species_10595335", "catalyst" ] ], "additional_components": [ "Q54KM0", "DDB_G0287261", "species_29926" ] }, "reaction_10595326": { "compartment": "compartment_70101", "id": "reaction_10595326", "reactome": "R-DDI-947514", "name": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10595310", "species_111707" ], "products": [ "species_29432", "species_10595315" ], "modifiers": [ [ "species_10595323", "catalyst" ] ], "additional_components": [ "species_29426", "Q55FS0", "DDB_G0267980", "Q55FS0", "DDB_G0267980", "species_29426", "Q54X04", "DDB_G0279287" ] }, "reaction_10595424": { "compartment": "compartment_70101", "id": "reaction_10595424", "reactome": "R-DDI-964970", "name": "2xPDXK:2xZn2+ phosphorylates PXL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_965131" ], "products": [ "species_29390", "species_29370" ], "modifiers": [ [ "species_10595417", "catalyst" ] ], "additional_components": [ "species_29426", "Q55EK9", "DDB_G0268628" ] }, "reaction_10602082": { "compartment": "compartment_70101", "id": "reaction_10602082", "reactome": "R-DDI-3204311", "name": "AOX1 oxidises PXL to PDXate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29368", "species_965131" ], "products": [ "species_3204324", "species_29408" ], "modifiers": [ [ "species_10602079", "catalyst" ] ], "additional_components": [ "CHEBI:33722", "CHEBI:44074", "species_113596", "Q54FB7", "DDB_G0291047" ] }, "reaction_10595434": { "compartment": "compartment_70101", "id": "reaction_10595434", "reactome": "R-DDI-965019", "name": "2xPNPO:2xFMN oxidizes PDXP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_964952" ], "products": [ "species_29390", "species_29408" ], "modifiers": [ [ "species_10595431", "catalyst" ] ], "additional_components": [ "Q54YS6", "DDB_G0278107", "species_76629" ] }, "reaction_10595420": { "compartment": "compartment_70101", "id": "reaction_10595420", "reactome": "R-DDI-964958", "name": "2xPDXK:2xZn2+ phosphorylates PXA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964945", "species_113592" ], "products": [ "species_29370", "species_965146" ], "modifiers": [ [ "species_10595417", "catalyst" ] ], "additional_components": [ "species_29426", "Q55EK9", "DDB_G0268628" ] }, "reaction_10595436": { "compartment": "compartment_70101", "id": "reaction_10595436", "reactome": "R-DDI-965079", "name": "2xPNPO:2xFMN oxidizes PXAP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29368", "species_965146" ], "products": [ "species_29390", "species_31633", "species_29408" ], "modifiers": [ [ "species_10595431", "catalyst" ] ], "additional_components": [ "Q54YS6", "DDB_G0278107", "species_76629" ] }, "reaction_10595422": { "compartment": "compartment_70101", "id": "reaction_10595422", "reactome": "R-DDI-964962", "name": "2xPDKX:2xZn2+ phosphorylates PDX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_965053" ], "products": [ "species_29370", "species_964952" ], "modifiers": [ [ "species_10595417", "catalyst" ] ], "additional_components": [ "species_29426", "Q55EK9", "DDB_G0268628" ] }, "reaction_10603568": { "compartment": "compartment_5460", "id": "reaction_10603568", "reactome": "R-DDI-4167509", "name": "Mitochondrial BTD hydrolyses BCTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3065953" ], "products": [ "species_29582", "species_29444" ], "modifiers": [ [ "species_10603565", "catalyst" ] ], "additional_components": [ "DDB_G0279675" ] }, "reaction_10603574": { "compartment": "compartment_70101", "id": "reaction_10603574", "reactome": "R-DDI-4167511", "name": "HLCS biotinylates ACACB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10603572", "species_199207" ], "products": [ "species_111294", "species_10587331", "species_76577" ], "modifiers": [ [ "species_10601704", "catalyst" ] ], "additional_components": [ "Q54J08", "DDB_G0288387", "species_266099", "Q54J08", "DDB_G0288387", "species_266099", "DDB_G0288791" ] }, "reaction_10601752": { "compartment": "compartment_70101", "id": "reaction_10601752", "reactome": "R-DDI-2993814", "name": "HLCS biotinylates ACACA:Mn2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10601750", "species_199207" ], "products": [ "species_111294", "species_10581619", "species_76577" ], "modifiers": [ [ "species_10601704", "catalyst" ] ], "additional_components": [ "Q54J08", "DDB_G0288387", "species_266099", "Q54J08", "DDB_G0288387", "species_266099", "DDB_G0288791" ] }, "reaction_10601707": { "compartment": "compartment_70101", "id": "reaction_10601707", "reactome": "R-DDI-2993447", "name": "HLCS biotinylates 6x(PCCA:PCCB)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601693", "species_113592", "species_199207" ], "products": [ "species_111294", "species_10601699", "species_76577" ], "modifiers": [ [ "species_10601704", "catalyst" ] ], "additional_components": [ "Q8T131", "DDB_G0276341", "Q553S7", "DDB_G0275355", "Q8T131", "DDB_G0276341", "Q553S7", "DDB_G0275355", "DDB_G0288791" ] }, "reaction_10602666": { "compartment": "compartment_70101", "id": "reaction_10602666", "reactome": "R-DDI-3323111", "name": "Cytoslic carboxylases translocate to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601699" ], "products": [ "species_10578275" ], "modifiers": [], "additional_components": [ "Q8T131", "DDB_G0276341", "Q553S7", "DDB_G0275355", "Q553S7", "DDB_G0275355", "Q8T131", "DDB_G0276341" ] }, "reaction_10601951": { "compartment": "compartment_984", "id": "reaction_10601951", "reactome": "R-DDI-3076905", "name": "Extracellular BTD hydrolyses BCTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3076887" ], "products": [ "species_199238", "species_351991" ], "modifiers": [ [ "species_10601948", "catalyst" ] ], "additional_components": [ "DDB_G0279675" ] }, "reaction_10586913": { "compartment": "compartment_70101", "id": "reaction_10586913", "reactome": "R-DDI-197972", "name": "DHF is reduced to tetrahydrofolate (THF)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73604", "species_29364" ], "products": [ "species_111355", "species_29366" ], "modifiers": [ [ "species_10586908", "catalyst" ] ], "additional_components": [ "DDB_G0286755" ] }, "reaction_10616513": { "compartment": "compartment_5460", "id": "reaction_10616513", "reactome": "R-DDI-6801456", "name": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113581", "species_5389850" ], "products": [ "species_200671", "species_6801451", "species_113593" ], "modifiers": [ [ "species_10612187", "catalyst" ] ], "additional_components": [ "Q54RI8", "DDB_G0283121", "Q54VK0", "DDB_G0283121" ] }, "reaction_10616966": { "compartment": "compartment_5460", "id": "reaction_10616966", "reactome": "R-DDI-6808487", "name": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_6808499", "species_113521" ], "products": [ "species_113529", "species_200679", "species_113600", "species_29376" ], "modifiers": [ [ "species_10616963", "catalyst" ] ], "additional_components": [ "Q54FY1", "DDB_G0290537", "Q54FY3", "DDB_G0290479", "Q54FY2", "DDB_G0290537" ] }, "reaction_10616516": { "compartment": "compartment_5460", "id": "reaction_10616516", "reactome": "R-DDI-6801462", "name": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6801458", "species_113521" ], "products": [ "species_5389850" ], "modifiers": [ [ "species_10616508", "catalyst" ] ], "additional_components": [ "Q54RI8", "DDB_G0283121", "Q54VK0", "DDB_G0283121" ] }, "reaction_10587398": { "compartment": "compartment_70616", "id": "reaction_10587398", "reactome": "R-DDI-200680", "name": "SLC25A32 transports THF from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111355" ], "products": [ "species_200671" ], "modifiers": [ [ "species_10587395", "catalyst" ] ], "additional_components": [ "DDB_G0271922" ] }, "reaction_10587400": { "compartment": "compartment_70101", "id": "reaction_10587400", "reactome": "R-DDI-200681", "name": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_200665", "species_113592" ], "products": [ "species_29372", "species_29370", "species_174404" ], "modifiers": [ [ "species_10586900", "catalyst" ] ], "additional_components": [ "DDB_G0292632" ] }, "reaction_10587405": { "compartment": "compartment_5460", "id": "reaction_10587405", "reactome": "R-DDI-200682", "name": "Mitochondrial FPGS-1 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200671", "species_113593", "species_113552" ], "products": [ "species_113548", "species_113581", "species_200679" ], "modifiers": [ [ "species_10587402", "catalyst" ] ], "additional_components": [ "DDB_G0292632" ] }, "reaction_10587372": { "compartment": "compartment_70101", "id": "reaction_10587372", "reactome": "R-DDI-200644", "name": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_200739" ], "products": [ "species_70106", "species_29364", "species_200640" ], "modifiers": [ [ "species_10587369", "catalyst" ] ], "additional_components": [ "Q54RI8", "DDB_G0283121" ] }, "reaction_10587377": { "compartment": "compartment_876", "id": "reaction_10587377", "reactome": "R-DDI-200652", "name": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200709" ], "products": [ "species_200665" ], "modifiers": [ [ "species_10587374", "catalyst" ] ], "additional_components": [ "DDB_G0272544" ] }, "reaction_10587408": { "compartment": "compartment_70101", "id": "reaction_10587408", "reactome": "R-DDI-200711", "name": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29460", "species_197969" ], "products": [ "species_29372", "species_29370", "species_111353" ], "modifiers": [ [ "species_10587369", "catalyst" ] ], "additional_components": [ "Q54RI8", "DDB_G0283121" ] }, "reaction_10587410": { "compartment": "compartment_70101", "id": "reaction_10587410", "reactome": "R-DDI-200718", "name": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200640" ], "products": [ "species_29366", "species_200739" ], "modifiers": [ [ "species_10587369", "catalyst" ] ], "additional_components": [ "Q54RI8", "DDB_G0283121" ] }, "reaction_10616982": { "compartment": "compartment_70101", "id": "reaction_10616982", "reactome": "R-DDI-6808496", "name": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111353", "species_29366" ], "products": [ "species_70106", "species_113528", "species_29364", "species_197969" ], "modifiers": [ [ "species_10616979", "catalyst" ] ], "additional_components": [ "Q54FY1", "DDB_G0290537", "Q54FY3", "DDB_G0290479", "Q54FY2", "DDB_G0290537" ] }, "reaction_10587380": { "compartment": "compartment_70101", "id": "reaction_10587380", "reactome": "R-DDI-200661", "name": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111353" ], "products": [ "species_29356", "species_200640" ], "modifiers": [ [ "species_10587369", "catalyst" ] ], "additional_components": [ "Q54RI8", "DDB_G0283121" ] }, "reaction_10586903": { "compartment": "compartment_70101", "id": "reaction_10586903", "reactome": "R-DDI-197958", "name": "FPGS-2 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_111355", "species_113592" ], "products": [ "species_29372", "species_29370", "species_197969" ], "modifiers": [ [ "species_10586900", "catalyst" ] ], "additional_components": [ "DDB_G0292632" ] }, "reaction_10587414": { "compartment": "compartment_70101", "id": "reaction_10587414", "reactome": "R-DDI-200740", "name": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_200640" ], "products": [ "species_111353" ], "modifiers": [ [ "species_10587369", "catalyst" ] ], "additional_components": [ "Q54RI8", "DDB_G0283121" ] }, "reaction_10627480": { "compartment": "compartment_70101", "id": "reaction_10627480", "reactome": "R-DDI-9709098", "name": "DHFR dimer reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197965", "species_70106", "species_29364" ], "products": [ "species_29366", "species_73604" ], "modifiers": [ [ "species_10627477", "catalyst" ] ], "additional_components": [ "Q54LA0", "DDB_G0286755" ] }, "reaction_10586911": { "compartment": "compartment_70101", "id": "reaction_10586911", "reactome": "R-DDI-197963", "name": "DHFR2 reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197965", "species_70106", "species_29364" ], "products": [ "species_29366", "species_73604" ], "modifiers": [ [ "species_10586908", "catalyst" ] ], "additional_components": [ "DDB_G0286755" ] }, "reaction_10616511": { "compartment": "compartment_5460", "id": "reaction_10616511", "reactome": "R-DDI-6801328", "name": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_5693984" ], "products": [ "species_6801458", "species_29362" ], "modifiers": [ [ "species_10616508", "catalyst" ] ], "additional_components": [ "Q54RI8", "DDB_G0283121", "Q54VK0", "DDB_G0283121" ] }, "reaction_10612190": { "compartment": "compartment_5460", "id": "reaction_10612190", "reactome": "R-DDI-5696839", "name": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6801451", "species_200671", "species_113593" ], "products": [ "species_113548", "species_113581", "species_5389850" ], "modifiers": [ [ "species_10612187", "catalyst" ] ], "additional_components": [ "Q54RI8", "DDB_G0283121", "Q54VK0", "DDB_G0283121" ] }, "reaction_10587390": { "compartment": "compartment_70101", "id": "reaction_10587390", "reactome": "R-DDI-200676", "name": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200739" ], "products": [ "species_29366", "species_174404" ], "modifiers": [ [ "species_10587387", "catalyst" ] ], "additional_components": [ "Q54X84", "DDB_G0279137" ] }, "reaction_10601859": { "compartment": "compartment_70101", "id": "reaction_10601859", "reactome": "R-DDI-3000238", "name": "LMBRD1 transports lysosomal Cbl to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3000239" ], "products": [ "species_3000241" ], "modifiers": [ [ "species_10601856", "catalyst" ] ], "additional_components": [ "DDB_G0287405" ] }, "reaction_10602051": { "compartment": "compartment_70101", "id": "reaction_10602051", "reactome": "R-DDI-3149518", "name": "MTRR reduces cob(II)alamin to meCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_71284", "species_29364", "species_10602048" ], "products": [ "species_29366", "species_10585476", "species_71285" ], "modifiers": [ [ "species_10602048", "catalyst" ] ], "additional_components": [ "species_3149479", "species_76629", "Q55G48", "DDB_G0267824", "species_113596", "Q54P92", "DDB_G0284699", "species_29426", "Q54P92", "DDB_G0284699", "species_29426", "CHEBI:28115", "species_76629", "Q55G48", "DDB_G0267824", "species_113596", "species_3149479", "species_76629", "Q55G48", "DDB_G0267824", "species_113596", "Q54P92", "DDB_G0284699", "species_29426" ] }, "reaction_10602067": { "compartment": "compartment_5460", "id": "reaction_10602067", "reactome": "R-DDI-3159253", "name": "MMAB transfers adenosyl group from ATP to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3159260", "species_113593" ], "products": [ "species_3159274", "species_3159297" ], "modifiers": [ [ "species_10602064", "catalyst" ] ], "additional_components": [ "Q54W51", "DDB_G0279905" ] }, "reaction_10602084": { "compartment": "compartment_70101", "id": "reaction_10602084", "reactome": "R-DDI-3204318", "name": "cob(II)alamin binds to MTRR:MTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602046", "species_3149479" ], "products": [ "species_10602048" ], "modifiers": [], "additional_components": [ "species_76629", "Q55G48", "DDB_G0267824", "species_113596", "Q54P92", "DDB_G0284699", "species_29426", "species_3149479", "species_76629", "Q55G48", "DDB_G0267824", "species_113596", "Q54P92", "DDB_G0284699", "species_29426" ] }, "reaction_10602054": { "compartment": "compartment_70101", "id": "reaction_10602054", "reactome": "R-DDI-3149519", "name": "MMACHC decyanates CNCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_10601956", "species_29364", "species_3149505" ], "products": [ "species_10601958", "species_29366", "species_1130611" ], "modifiers": [ [ "species_10601956", "catalyst" ] ], "additional_components": [ "DDB_G0274205", "Q86KB5", "DDB_G0274205", "species_3149479", "DDB_G0274205" ] }, "reaction_10601961": { "compartment": "compartment_70101", "id": "reaction_10601961", "reactome": "R-DDI-3095889", "name": "MMACHC reduces Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3000241", "species_70106", "species_10601956", "species_29364" ], "products": [ "species_10601958", "species_29366" ], "modifiers": [ [ "species_10601956", "catalyst" ] ], "additional_components": [ "DDB_G0274205", "Q86KB5", "DDB_G0274205", "species_3149479", "DDB_G0274205" ] }, "reaction_10602057": { "compartment": "compartment_70101", "id": "reaction_10602057", "reactome": "R-DDI-3149539", "name": "MTR transfers CH3 group from MTHF to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200665", "species_10585480" ], "products": [ "species_111355", "species_10585476" ], "modifiers": [ [ "species_10585480", "catalyst" ] ], "additional_components": [ "Q54P92", "DDB_G0284699", "species_29426", "species_3159260", "species_76629", "Q55G48", "DDB_G0267824", "species_113596", "Q54P92", "DDB_G0284699", "species_29426", "CHEBI:28115", "species_76629", "Q55G48", "DDB_G0267824", "species_113596", "Q54P92", "DDB_G0284699", "species_29426", "species_3159260", "species_76629", "Q55G48", "DDB_G0267824", "species_113596" ] }, "reaction_10604780": { "compartment": "compartment_70101", "id": "reaction_10604780", "reactome": "R-DDI-5223313", "name": "ABCD4 may transport Cbl from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_3000239" ], "products": [ "species_29372", "species_3000241", "species_29370" ], "modifiers": [ [ "species_10604777", "catalyst" ] ], "additional_components": [ "DDB_G0279919" ] }, "reaction_10601964": { "compartment": "compartment_70101", "id": "reaction_10601964", "reactome": "R-DDI-3095901", "name": "ABCC1 transports cytosolic Cbl to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_3000241", "species_113592" ], "products": [ "species_29372", "species_29370", "species_3000125" ], "modifiers": [ [ "species_10589142", "catalyst" ] ], "additional_components": [ "Q54JR2", "DDB_G0287691", "Q54LE6", "DDB_G0286559", "Q8ST87", "DDB_G0280977", "Q54P13", "DDB_G0284867", "Q54U44", "DDB_G0280973" ] }, "reaction_10620675": { "compartment": "compartment_70101", "id": "reaction_10620675", "reactome": "R-DDI-8869627", "name": "NMRK2 phosphorylates NR to yield NMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869377" ], "products": [ "species_8869353", "species_70106", "species_29370" ], "modifiers": [ [ "species_10620669", "catalyst" ] ], "additional_components": [ "Q8T154", "DDB_G0274559", "Q55EL3", "DDB_G0269034" ] }, "reaction_10620672": { "compartment": "compartment_70101", "id": "reaction_10620672", "reactome": "R-DDI-8869607", "name": "NMRK2 phosphorylates NAR to yield NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869365" ], "products": [ "species_70106", "species_29370", "species_197220" ], "modifiers": [ [ "species_10620669", "catalyst" ] ], "additional_components": [ "Q8T154", "DDB_G0274559", "Q55EL3", "DDB_G0269034" ] }, "reaction_10586867": { "compartment": "compartment_70101", "id": "reaction_10586867", "reactome": "R-DDI-197198", "name": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29360" ], "products": [ "species_29370", "species_29366" ], "modifiers": [ [ "species_10586864", "catalyst" ] ], "additional_components": [ "species_29426", "Q54D76", "DDB_G0292442" ] }, "reaction_10586885": { "compartment": "compartment_70101", "id": "reaction_10586885", "reactome": "R-DDI-197268", "name": "QPRT transfers PRIB to QUIN to form NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_70106", "species_197238" ], "products": [ "species_111294", "species_113528", "species_197220" ], "modifiers": [ [ "species_10586882", "catalyst" ] ], "additional_components": [ "DDB_G0272462" ] }, "reaction_10620678": { "compartment": "compartment_70101", "id": "reaction_10620678", "reactome": "R-DDI-8869633", "name": "NMRK1 phosphorylates NR to yield NMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869377" ], "products": [ "species_8869353", "species_70106", "species_29370" ], "modifiers": [ [ "species_10620660", "catalyst" ] ], "additional_components": [ "Q8T154", "DDB_G0274559", "Q55EL3", "DDB_G0269034" ] }, "reaction_10616677": { "compartment": "compartment_5460", "id": "reaction_10616677", "reactome": "R-DDI-6806967", "name": "CARKD dehydrates S-NAD(P)HX to NADPH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_6807477" ], "products": [ "species_113548", "species_113581", "species_113529", "species_113600" ], "modifiers": [ [ "species_10616674", "catalyst" ] ], "additional_components": [ "DDB_G0290799" ] }, "reaction_10586857": { "compartment": "compartment_70101", "id": "reaction_10586857", "reactome": "R-DDI-197186", "name": "NAPRT1 dimer transfers PRIB to NCA to form NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_197230", "species_70106" ], "products": [ "species_111294", "species_197220" ], "modifiers": [ [ "species_10586854", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q55G10", "DDB_G0268472" ] }, "reaction_10617321": { "compartment": "compartment_17951", "id": "reaction_10617321", "reactome": "R-DDI-6809287", "name": "NUDT12 hydrolyses NADH to NMNH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_192305", "species_389620" ], "products": [ "species_6809289", "species_193465" ], "modifiers": [ [ "species_10617318", "catalyst" ] ], "additional_components": [ "DDB_G0272048" ] }, "reaction_10623038": { "compartment": "compartment_70101", "id": "reaction_10623038", "reactome": "R-DDI-8938073", "name": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8938276", "species_29360" ], "products": [ "species_197277", "species_8938282" ], "modifiers": [ [ "species_10623035", "catalyst" ] ], "additional_components": [ "Q54JP6", "DDB_G0287911" ] }, "reaction_10616669": { "compartment": "compartment_5460", "id": "reaction_10616669", "reactome": "R-DDI-6806966", "name": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6807473" ], "products": [ "species_6807477" ], "modifiers": [ [ "species_10616666", "catalyst" ] ], "additional_components": [ "Q55CV0", "DDB_G0269890" ] }, "reaction_10620663": { "compartment": "compartment_70101", "id": "reaction_10620663", "reactome": "R-DDI-8869606", "name": "NMRK1 phosphorylates NAR to yield NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869365" ], "products": [ "species_70106", "species_29370", "species_197220" ], "modifiers": [ [ "species_10620660", "catalyst" ] ], "additional_components": [ "Q8T154", "DDB_G0274559", "Q55EL3", "DDB_G0269034" ] }, "reaction_10587352": { "compartment": "compartment_5460", "id": "reaction_10587352", "reactome": "R-DDI-200474", "name": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8938083", "species_113593" ], "products": [ "species_8938078", "species_8938090" ], "modifiers": [ [ "species_10587349", "catalyst" ] ], "additional_components": [ "Q54IH4", "DDB_G0288757", "species_29926" ] }, "reaction_10623128": { "compartment": "compartment_70101", "id": "reaction_10623128", "reactome": "R-DDI-8939959", "name": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8869353", "species_113592" ], "products": [ "species_1132084", "species_29360" ], "modifiers": [ [ "species_10586874", "catalyst" ] ], "additional_components": [ "species_29926", "Q54IH4", "DDB_G0288757" ] }, "reaction_10586877": { "compartment": "compartment_70101", "id": "reaction_10586877", "reactome": "R-DDI-197235", "name": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_197220" ], "products": [ "species_197256", "species_1132084" ], "modifiers": [ [ "species_10586874", "catalyst" ] ], "additional_components": [ "species_29926", "Q54IH4", "DDB_G0288757" ] }, "reaction_10586895": { "compartment": "compartment_70101", "id": "reaction_10586895", "reactome": "R-DDI-197271", "name": "NADSYN1 hexamer amidates NAAD to NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_197256", "species_113592", "species_29472" ], "products": [ "species_111294", "species_29404", "species_76577", "species_29360" ], "modifiers": [ [ "species_10586892", "catalyst" ] ], "additional_components": [ "Q54ML1", "DDB_G0285877" ] }, "reaction_10587359": { "compartment": "compartment_7660", "id": "reaction_10587359", "reactome": "R-DDI-200512", "name": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200492", "species_29358" ], "products": [ "species_8878981", "species_200499" ], "modifiers": [ [ "species_10587356", "catalyst" ] ], "additional_components": [ "Q54IH4", "DDB_G0288757", "species_29426" ] }, "reaction_10597890": { "compartment": "compartment_70101", "id": "reaction_10597890", "reactome": "R-DDI-1474184", "name": "DHNTP is dephosphorylated by PTPS to PTHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1474124" ], "products": [ "species_1475054", "species_1474179" ], "modifiers": [ [ "species_10597887", "catalyst" ] ], "additional_components": [ "species_29426", "Q1ZXI0", "DDB_G0279095" ] }, "reaction_10598274": { "compartment": "compartment_70101", "id": "reaction_10598274", "reactome": "R-DDI-1497853", "name": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10598272" ], "products": [ "species_10597898", "species_29370" ], "modifiers": [ [ "species_10597913", "catalyst" ] ], "additional_components": [ "Q54GP3", "DDB_G0290009", "Q54GP3", "DDB_G0290009", "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029" ] }, "reaction_10597879": { "compartment": "compartment_70101", "id": "reaction_10597879", "reactome": "R-DDI-1474146", "name": "GCH1 reduces GTP to dihydroneopterin triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29356" ], "products": [ "species_1474124", "species_29460" ], "modifiers": [ [ "species_10597876", "catalyst" ], [ "species_29502", "catalyst" ], [ "species_29870", "inhibitor" ] ], "additional_components": [ "Q94465", "DDB_G0288481" ] }, "reaction_10597901": { "compartment": "compartment_70101", "id": "reaction_10597901", "reactome": "R-DDI-1475414", "name": "PTHP is reduced to BH4 by sepiapterin reductase (SPR)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1474179", "species_29364" ], "products": [ "species_29870", "species_29366" ], "modifiers": [ [ "species_10597898", "catalyst" ] ], "additional_components": [ "Q54GP3", "DDB_G0290009" ] }, "reaction_10597916": { "compartment": "compartment_70101", "id": "reaction_10597916", "reactome": "R-DDI-1475422", "name": "PTPS is phosphorylated by cGMP-dependant protein kinase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10597905" ], "products": [ "species_10597887", "species_29370" ], "modifiers": [ [ "species_10597913", "catalyst" ] ], "additional_components": [ "Q1ZXI0", "DDB_G0279095", "species_29426", "Q1ZXI0", "DDB_G0279095", "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029" ] }, "reaction_10600514": { "compartment": "compartment_5460", "id": "reaction_10600514", "reactome": "R-DDI-2162186", "name": "DeMQ10H2 is methylated to Q10H2 by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162265", "species_2162212" ], "products": [ "species_2162252", "species_113529", "species_2162198" ], "modifiers": [ [ "species_10600511", "catalyst" ] ], "additional_components": [ "DDB_G0279037" ] }, "reaction_10600522": { "compartment": "compartment_70616", "id": "reaction_10600522", "reactome": "R-DDI-2162192", "name": "PHB and all-E-10PrP2 are combined into DHB by COQ2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162214", "species_2162213" ], "products": [ "species_2162207", "species_159450" ], "modifiers": [ [ "species_10600519", "catalyst" ] ], "additional_components": [ "DDB_G0281241" ] }, "reaction_10600541": { "compartment": "compartment_5460", "id": "reaction_10600541", "reactome": "R-DDI-2162253", "name": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162257", "species_2162256" ], "products": [ "species_159450", "species_2162214" ], "modifiers": [ [ "species_10600538", "catalyst" ] ], "additional_components": [ "Q54VJ9", "DDB_G0280293", "species_29926" ] }, "reaction_10600525": { "compartment": "compartment_5460", "id": "reaction_10600525", "reactome": "R-DDI-2162193", "name": "DHDB is methylated to MHDB by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162265", "species_2162209" ], "products": [ "species_2162252", "species_113529", "species_2162215" ], "modifiers": [ [ "species_10600511", "catalyst" ] ], "additional_components": [ "DDB_G0279037" ] }, "reaction_10616648": { "compartment": "compartment_17957", "id": "reaction_10616648", "reactome": "R-DDI-6806674", "name": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6806891", "species_6806657" ], "products": [ "species_6806362", "species_6806656" ], "modifiers": [ [ "species_10616645", "catalyst" ] ], "additional_components": [ "DDB_G0287509" ] }, "reaction_10600503": { "compartment": "compartment_70101", "id": "reaction_10600503", "reactome": "R-DDI-2162066", "name": "carbovir + IMP => carbovir monophosphate + inosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161514", "species_29602" ], "products": [ "species_2161176", "species_83927" ], "modifiers": [ [ "species_10581209", "catalyst" ] ], "additional_components": [ "Q54XC1", "DDB_G0279053", "species_29926" ] }, "reaction_10600506": { "compartment": "compartment_70101", "id": "reaction_10600506", "reactome": "R-DDI-2162078", "name": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161185", "species_29360" ], "products": [ "species_70106", "species_2162081", "species_73473" ], "modifiers": [ [ "species_10578698", "catalyst" ] ], "additional_components": [ "species_29426", "Q54TC2", "DDB_G0281865" ] }, "reaction_10599457": { "compartment": "compartment_70101", "id": "reaction_10599457", "reactome": "R-DDI-1855205", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994170" ], "products": [ "species_29372", "species_114520" ], "modifiers": [ [ "species_10599454", "catalyst" ] ], "additional_components": [ "species_29926", "Q8T9S7", "DDB_G0286557" ] }, "reaction_10599491": { "compartment": "compartment_876", "id": "reaction_10599491", "reactome": "R-DDI-1855213", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994170" ], "products": [ "species_29372", "species_994123" ], "modifiers": [ [ "species_10599488", "catalyst" ] ], "additional_components": [ "Q54PV1", "DDB_G0284187", "Q54W40", "DDB_G0279927", "Q8I7P3", "DDB_G0267462" ] }, "reaction_10599381": { "compartment": "compartment_70101", "id": "reaction_10599381", "reactome": "R-DDI-1855169", "name": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629741" ], "products": [ "species_994146", "species_29370" ], "modifiers": [ [ "species_10599364", "catalyst" ] ], "additional_components": [ "species_29926", "Q55D87", "DDB_G0269746" ] }, "reaction_10599367": { "compartment": "compartment_70101", "id": "reaction_10599367", "reactome": "R-DDI-1855159", "name": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994146", "species_29356" ], "products": [ "species_29372", "species_1629741" ], "modifiers": [ [ "species_10599364", "catalyst" ] ], "additional_components": [ "species_29926", "Q55D87", "DDB_G0269746" ] }, "reaction_10599417": { "compartment": "compartment_70101", "id": "reaction_10599417", "reactome": "R-DDI-1855177", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10599414", "catalyst" ] ], "additional_components": [ "Q02158", "DDB_G0292736", "species_74112" ] }, "reaction_10599449": { "compartment": "compartment_70101", "id": "reaction_10599449", "reactome": "R-DDI-1855197", "name": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994123" ], "products": [ "species_994146", "species_29370" ], "modifiers": [ [ "species_10599364", "catalyst" ] ], "additional_components": [ "species_29926", "Q55D87", "DDB_G0269746" ] }, "reaction_10599288": { "compartment": "compartment_70101", "id": "reaction_10599288", "reactome": "R-DDI-1855153", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_114520" ], "products": [ "species_29370", "species_994170" ], "modifiers": [ [ "species_10599285", "catalyst" ] ], "additional_components": [ "Q54TI0", "DDB_G0281737", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917" ] }, "reaction_10599384": { "compartment": "compartment_70101", "id": "reaction_10599384", "reactome": "R-DDI-1855171", "name": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994146", "species_29356" ], "products": [ "species_29372", "species_994123" ], "modifiers": [ [ "species_10599364", "catalyst" ] ], "additional_components": [ "species_29926", "Q55D87", "DDB_G0269746" ] }, "reaction_10599547": { "compartment": "compartment_876", "id": "reaction_10599547", "reactome": "R-DDI-1855221", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10599544", "catalyst" ] ], "additional_components": [ "Q02158", "DDB_G0292736", "species_74112" ] }, "reaction_10599387": { "compartment": "compartment_70101", "id": "reaction_10599387", "reactome": "R-DDI-1855172", "name": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994123" ], "products": [ "species_29370", "species_994170" ], "modifiers": [ [ "species_10599364", "catalyst" ] ], "additional_components": [ "species_29926", "Q55D87", "DDB_G0269746" ] }, "reaction_10599514": { "compartment": "compartment_12045", "id": "reaction_10599514", "reactome": "R-DDI-1855214", "name": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023856", "species_29356" ], "products": [ "species_114520", "species_1500596" ], "modifiers": [ [ "species_10599511", "catalyst" ] ], "additional_components": [ "Q54SA1", "DDB_G0282579", "Q54K50", "DDB_G0287649", "species_74112", "Q02158", "DDB_G0292736" ] }, "reaction_10599519": { "compartment": "compartment_70101", "id": "reaction_10599519", "reactome": "R-DDI-1855218", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994170" ], "products": [ "species_29372", "species_994123" ], "modifiers": [ [ "species_10599516", "catalyst" ] ], "additional_components": [ "species_29926", "Q55D87", "DDB_G0269746", "Q8I7P3", "DDB_G0267462", "Q54PV1", "DDB_G0284187", "Q54W40", "DDB_G0279927", "Q54D97", "DDB_G0292392" ] }, "reaction_10599345": { "compartment": "compartment_7660", "id": "reaction_10599345", "reactome": "R-DDI-1855157", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023932" ], "products": [ "species_113582", "species_2023931" ], "modifiers": [ [ "species_10599342", "catalyst" ] ], "additional_components": [ "Q54B75", "DDB_G0293860", "Q55AP4", "DDB_G0293860", "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0293860" ] }, "reaction_10599440": { "compartment": "compartment_7660", "id": "reaction_10599440", "reactome": "R-DDI-1855185", "name": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023935" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10599437", "catalyst" ] ], "additional_components": [ "DDB_G0281737" ] }, "reaction_10599568": { "compartment": "compartment_7660", "id": "reaction_10599568", "reactome": "R-DDI-1855230", "name": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023922" ], "products": [ "species_113582", "species_2023948" ], "modifiers": [ [ "species_10599342", "catalyst" ] ], "additional_components": [ "Q54B75", "DDB_G0293860", "Q55AP4", "DDB_G0293860", "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0293860" ] }, "reaction_10599460": { "compartment": "compartment_7660", "id": "reaction_10599460", "reactome": "R-DDI-1855206", "name": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023891" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10599437", "catalyst" ] ], "additional_components": [ "DDB_G0281737" ] }, "reaction_10599556": { "compartment": "compartment_7660", "id": "reaction_10599556", "reactome": "R-DDI-1855224", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023940" ], "products": [ "species_113582", "species_2023941" ], "modifiers": [ [ "species_10599342", "catalyst" ] ], "additional_components": [ "Q54B75", "DDB_G0293860", "Q55AP4", "DDB_G0293860", "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0293860" ] }, "reaction_10599463": { "compartment": "compartment_7660", "id": "reaction_10599463", "reactome": "R-DDI-1855207", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023929" ], "products": [ "species_113582", "species_2023940" ], "modifiers": [ [ "species_10599342", "catalyst" ] ], "additional_components": [ "Q54B75", "DDB_G0293860", "Q55AP4", "DDB_G0293860", "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0293860" ] }, "reaction_10599574": { "compartment": "compartment_7660", "id": "reaction_10599574", "reactome": "R-DDI-1855233", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023907" ], "products": [ "species_113582", "species_2023891" ], "modifiers": [ [ "species_10599437", "catalyst" ] ], "additional_components": [ "DDB_G0281737" ] }, "reaction_10599400": { "compartment": "compartment_7660", "id": "reaction_10599400", "reactome": "R-DDI-1855176", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023901" ], "products": [ "species_113582", "species_2023929" ], "modifiers": [ [ "species_10599397", "catalyst" ] ], "additional_components": [ "DDB_G0288351" ] }, "reaction_10599435": { "compartment": "compartment_7660", "id": "reaction_10599435", "reactome": "R-DDI-1855181", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023901" ], "products": [ "species_113582", "species_2023922" ], "modifiers": [ [ "species_10599342", "catalyst" ] ], "additional_components": [ "Q54B75", "DDB_G0293860", "Q55AP4", "DDB_G0293860", "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0293860" ] }, "reaction_10599565": { "compartment": "compartment_7660", "id": "reaction_10599565", "reactome": "R-DDI-1855228", "name": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023892" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10599437", "catalyst" ] ], "additional_components": [ "DDB_G0281737" ] }, "reaction_10599473": { "compartment": "compartment_70101", "id": "reaction_10599473", "reactome": "R-DDI-1855210", "name": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629731" ], "products": [ "species_29372", "species_426910" ], "modifiers": [ [ "species_10599305", "catalyst" ] ], "additional_components": [ "species_29926", "Q54U72", "DDB_G0281239" ] }, "reaction_10607633": { "compartment": "compartment_70101", "id": "reaction_10607633", "reactome": "R-DDI-5678327", "name": "MIOX oxidises Ins to GlcA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_426910" ], "products": [ "species_29356", "species_70106", "species_2162232" ], "modifiers": [ [ "species_10607630", "catalyst" ] ], "additional_components": [ "species_71067", "Q54GH4", "DDB_G0290161" ] }, "reaction_10599392": { "compartment": "compartment_70101", "id": "reaction_10599392", "reactome": "R-DDI-1855174", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_114520" ], "products": [ "species_29372", "species_1629739" ], "modifiers": [ [ "species_10599389", "catalyst" ] ], "additional_components": [ "Q8I7P3", "DDB_G0267462", "Q54PV1", "DDB_G0284187", "Q54W40", "DDB_G0279927", "Q54D97", "DDB_G0292392" ] }, "reaction_10599571": { "compartment": "compartment_70101", "id": "reaction_10599571", "reactome": "R-DDI-1855232", "name": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994123" ], "products": [ "species_29372", "species_1629746" ], "modifiers": [ [ "species_10599467", "catalyst" ] ], "additional_components": [ "species_29926", "Q869K3", "DDB_G0275663" ] }, "reaction_10599427": { "compartment": "compartment_70101", "id": "reaction_10599427", "reactome": "R-DDI-1855178", "name": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629756" ], "products": [ "species_1629731" ], "modifiers": [ [ "species_10599424", "catalyst" ] ], "additional_components": [ "species_29360", "Q54N49", "DDB_G0285505" ] }, "reaction_10599476": { "compartment": "compartment_70101", "id": "reaction_10599476", "reactome": "R-DDI-1855211", "name": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629753" ], "products": [ "species_29372", "species_426910" ], "modifiers": [ [ "species_10599305", "catalyst" ] ], "additional_components": [ "species_29926", "Q54U72", "DDB_G0281239" ] }, "reaction_10599308": { "compartment": "compartment_70101", "id": "reaction_10599308", "reactome": "R-DDI-1855154", "name": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_870330" ], "products": [ "species_29372", "species_426910" ], "modifiers": [ [ "species_10599305", "catalyst" ] ], "additional_components": [ "species_29926", "Q54U72", "DDB_G0281239" ] }, "reaction_10599550": { "compartment": "compartment_876", "id": "reaction_10599550", "reactome": "R-DDI-1855222", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_114520" ], "products": [ "species_29372", "species_1629739" ], "modifiers": [ [ "species_10599484", "catalyst" ] ], "additional_components": [ "Q54PV1", "DDB_G0284187", "Q54W40", "DDB_G0279927", "Q8I7P3", "DDB_G0267462" ] }, "reaction_10599470": { "compartment": "compartment_70101", "id": "reaction_10599470", "reactome": "R-DDI-1855208", "name": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629739" ], "products": [ "species_29372", "species_1629753" ], "modifiers": [ [ "species_10599467", "catalyst" ] ], "additional_components": [ "species_29926", "Q869K3", "DDB_G0275663" ] }, "reaction_10599378": { "compartment": "compartment_17957", "id": "reaction_10599378", "reactome": "R-DDI-1855163", "name": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_2024008" ], "products": [ "species_113551", "species_2024012" ], "modifiers": [ [ "species_10599375", "catalyst" ] ], "additional_components": [ "DDB_G0286993" ] }, "reaction_10599559": { "compartment": "compartment_17957", "id": "reaction_10599559", "reactome": "R-DDI-1855225", "name": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_2024018" ], "products": [ "species_113551", "species_2564836" ], "modifiers": [ [ "species_10599375", "catalyst" ] ], "additional_components": [ "DDB_G0286993" ] }, "reaction_10599452": { "compartment": "compartment_17957", "id": "reaction_10599452", "reactome": "R-DDI-1855200", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_2024002" ], "products": [ "species_113551", "species_2024016" ], "modifiers": [ [ "species_10599375", "catalyst" ] ], "additional_components": [ "DDB_G0286993" ] }, "reaction_10583665": { "compartment": "compartment_70101", "id": "reaction_10583665", "reactome": "R-DDI-156526", "name": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_5423605", "species_29364" ], "products": [ "species_29356", "species_159211", "species_29366" ], "modifiers": [ [ "species_10582258", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10605385": { "compartment": "compartment_70101", "id": "reaction_10605385", "reactome": "R-DDI-5433074", "name": "ACY1:Zn2+ dimer hydrolyses mercapturic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5490236", "species_29356" ], "products": [ "species_2022890", "species_5490231" ], "modifiers": [ [ "species_10605382", "catalyst" ] ], "additional_components": [ "CHEBI:78580", "CHEBI:78585", "CHEBI:78583", "CHEBI:78578", "species_29426", "Q55DP8", "DDB_G0270562" ] }, "reaction_10605373": { "compartment": "compartment_70101", "id": "reaction_10605373", "reactome": "R-DDI-5423647", "name": "CYP2A13 oxidises AFM1 to AFM1E", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5423629", "species_70106", "species_29368", "species_29364" ], "products": [ "species_29356", "species_5423657", "species_29366" ], "modifiers": [ [ "species_10582258", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10605375": { "compartment": "compartment_70101", "id": "reaction_10605375", "reactome": "R-DDI-5423653", "name": "MGST trimers transfer GS from GSH to AFXBO and AFNBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_5423723" ], "products": [ "species_5423730" ], "modifiers": [ [ "species_10585705", "catalyst" ] ], "additional_components": [ "species_159211", "CHEBI:78586", "CHEBI:78581", "CHEBI:78587", "Q54GA9", "DDB_G0290291" ] }, "reaction_10623024": { "compartment": "compartment_70101", "id": "reaction_10623024", "reactome": "R-DDI-8937442", "name": "CES3 hydrolyses CHEST to CHOL and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_163579" ], "products": [ "species_8876730", "species_216762" ], "modifiers": [ [ "species_10623021", "catalyst" ] ], "additional_components": [ "P21837", "DDB_G0285419", "P18142", "DDB_G0283085", "Q54N21", "DDB_G0291344", "Q54ET7", "DDB_G0291344", "Q86L18", "DDB_G0291344", "Q54WD8", "DDB_G0291344" ] }, "reaction_10583621": { "compartment": "compartment_70101", "id": "reaction_10583621", "reactome": "R-DDI-141200", "name": "MAOB:FAD oxidatively deaminates of PEA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500605", "species_29368" ], "products": [ "species_500607", "species_29382", "species_29408" ], "modifiers": [ [ "species_10583618", "catalyst" ] ], "additional_components": [ "Q54IT3", "DDB_G0288541", "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10583623": { "compartment": "compartment_70101", "id": "reaction_10583623", "reactome": "R-DDI-141202", "name": "MAOB:FAD oxidatively deaminates TYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500606", "species_29368" ], "products": [ "species_500608", "species_29382", "species_29408" ], "modifiers": [ [ "species_10583618", "catalyst" ] ], "additional_components": [ "Q54IT3", "DDB_G0288541", "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10611904": { "compartment": "compartment_5460", "id": "reaction_10611904", "reactome": "R-DDI-5696091", "name": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113532", "species_113526", "species_113521" ], "products": [ "species_113529", "species_29362", "species_113539" ], "modifiers": [ [ "species_10611901", "catalyst" ] ], "additional_components": [ "Q54FY3", "DDB_G0290479", "Q54FY1", "DDB_G0290537", "Q54FY2", "DDB_G0290537" ] }, "reaction_10578691": { "compartment": "compartment_70101", "id": "reaction_10578691", "reactome": "R-DDI-71691", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29510", "species_29360" ], "products": [ "species_70106", "species_29416", "species_73473" ], "modifiers": [ [ "species_10578688", "catalyst" ] ], "additional_components": [ "Q54IU0", "DDB_G0288521" ] }, "reaction_10578727": { "compartment": "compartment_5460", "id": "reaction_10578727", "reactome": "R-DDI-71723", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113532", "species_113526", "species_113521" ], "products": [ "species_113529", "species_29362", "species_113539" ], "modifiers": [ [ "species_10578724", "catalyst" ] ], "additional_components": [ "Q54FY3", "DDB_G0290479" ] }, "reaction_10578745": { "compartment": "compartment_70101", "id": "reaction_10578745", "reactome": "R-DDI-71735", "name": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29416", "species_76194" ], "products": [ "species_111294", "species_76183", "species_76577" ], "modifiers": [ [ "species_10578742", "catalyst" ] ], "additional_components": [ "DDB_G0277815" ] }, "reaction_10578717": { "compartment": "compartment_70101", "id": "reaction_10578717", "reactome": "R-DDI-71707", "name": "ethanol + NAD+ => acetaldehyde + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30203", "species_29360" ], "products": [ "species_70106", "species_29510", "species_73473" ], "modifiers": [ [ "species_10578714", "catalyst" ] ], "additional_components": [ "species_29426", "Q54TC2", "DDB_G0281865" ] }, "reaction_10611260": { "compartment": "compartment_70101", "id": "reaction_10611260", "reactome": "R-DDI-5692237", "name": "ADH5 oxidises S-HMGSH to S-FGSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5692221", "species_29360" ], "products": [ "species_5692249", "species_70106", "species_73473" ], "modifiers": [ [ "species_10611257", "catalyst" ] ], "additional_components": [ "species_29426", "Q54TC2", "DDB_G0281865" ] }, "reaction_10593006": { "compartment": "compartment_5460", "id": "reaction_10593006", "reactome": "R-DDI-449911", "name": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_113539" ], "products": [ "species_159448", "species_159450", "species_113559" ], "modifiers": [ [ "species_10593003", "catalyst" ] ], "additional_components": [ "DDB_G0277815" ] }, "reaction_10588946": { "compartment": "compartment_17960", "id": "reaction_10588946", "reactome": "R-DDI-217258", "name": "FMO2:FAD:Mg2+ S-oxidises MTZ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_217315" ], "products": [ "species_113519", "species_113564", "species_217320" ], "modifiers": [ [ "species_10588943", "catalyst" ] ], "additional_components": [ "species_29926", "species_113596", "Q54GT1", "DDB_G0289931", "Q54GT2", "DDB_G0289931", "Q54GT4", "DDB_G0289931", "Q54H02", "DDB_G0289931", "Q54H99", "DDB_G0289931", "Q55AS8", "DDB_G0289931", "Q54GT0", "DDB_G0289931" ] }, "reaction_10588925": { "compartment": "compartment_17960", "id": "reaction_10588925", "reactome": "R-DDI-217255", "name": "FMO1:FAD N-oxidises TAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_159154" ], "products": [ "species_113519", "species_113564", "species_217269" ], "modifiers": [ [ "species_10588922", "catalyst" ] ], "additional_components": [ "species_113596", "Q54GT4", "DDB_G0289931", "Q54H02", "DDB_G0289931", "Q54H99", "DDB_G0289931", "Q55AS8", "DDB_G0289931", "Q54GT0", "DDB_G0289931", "Q54GT1", "DDB_G0289931", "Q54GT2", "DDB_G0289931" ] }, "reaction_10583597": { "compartment": "compartment_17957", "id": "reaction_10583597", "reactome": "R-DDI-139970", "name": "FMO3:FAD N-oxidises TMA to TMAO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_30373", "species_113601" ], "products": [ "species_113519", "species_113564", "species_140963" ], "modifiers": [ [ "species_10583594", "catalyst" ] ], "additional_components": [ "species_113596", "Q54H99", "DDB_G0289931", "Q54GT2", "DDB_G0289931", "Q54GT4", "DDB_G0289931", "Q55AS8", "DDB_G0289931", "Q54GT0", "DDB_G0289931", "Q54GT1", "DDB_G0289931", "Q54H02", "DDB_G0289931" ] }, "reaction_10611272": { "compartment": "compartment_70101", "id": "reaction_10611272", "reactome": "R-DDI-5692283", "name": "ALD3A1 oxidises 4HPCP to CXPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5692409", "species_29356", "species_29366" ], "products": [ "species_70106", "species_5692433", "species_29364" ], "modifiers": [ [ "species_10611269", "catalyst" ] ], "additional_components": [ "DDB_G0292270" ] }, "reaction_10608763": { "compartment": "compartment_12045", "id": "reaction_10608763", "reactome": "R-DDI-5689000", "name": "AADAC deacetylates PHEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5689006" ], "products": [ "species_5689001", "species_5688995" ], "modifiers": [ [ "species_10608760", "catalyst" ] ], "additional_components": [ "DDB_G0283819" ] }, "reaction_10611434": { "compartment": "compartment_17957", "id": "reaction_10611434", "reactome": "R-DDI-5693691", "name": "CES1 trimer.CES2 hydrolyse COCN to BEG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_5693702" ], "products": [ "species_156540", "species_5693711", "species_5693712" ], "modifiers": [ [ "species_10611431", "catalyst" ] ], "additional_components": [ "Q54WD8", "DDB_G0291344", "Q86L18", "DDB_G0291344", "P18142", "DDB_G0283085", "P21837", "DDB_G0285419", "Q54ET7", "DDB_G0291344", "Q54N21", "DDB_G0291344" ] }, "reaction_10588801": { "compartment": "compartment_12045", "id": "reaction_10588801", "reactome": "R-DDI-211910", "name": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_211906", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211894" ], "modifiers": [ [ "species_10588798", "catalyst" ] ], "additional_components": [ "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778" ] }, "reaction_10588881": { "compartment": "compartment_12045", "id": "reaction_10588881", "reactome": "R-DDI-212005", "name": "CYP2F1 dehydrogenates 3-methylindole", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_213162", "species_113601" ], "products": [ "species_113519", "species_113564", "species_213163" ], "modifiers": [ [ "species_10588871", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10588803": { "compartment": "compartment_12045", "id": "reaction_10588803", "reactome": "R-DDI-211929", "name": "CYP2C19 5-hydroxylates omeprazole", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_211892", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211944" ], "modifiers": [ [ "species_10588798", "catalyst" ] ], "additional_components": [ "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778" ] }, "reaction_10582274": { "compartment": "compartment_12045", "id": "reaction_10582274", "reactome": "R-DDI-76453", "name": "Coumarin is 7-hydroxylated by CYP2A6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_76328", "species_113601" ], "products": [ "species_113519", "species_113564", "species_76452" ], "modifiers": [ [ "species_10582271", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10588869": { "compartment": "compartment_12045", "id": "reaction_10588869", "reactome": "R-DDI-211988", "name": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_211855", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211937" ], "modifiers": [ [ "species_10588798", "catalyst" ] ], "additional_components": [ "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778" ] }, "reaction_10582327": { "compartment": "compartment_12045", "id": "reaction_10582327", "reactome": "R-DDI-76456", "name": "O-atom dealkylation of dextromethorphan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_39703", "species_113601" ], "products": [ "species_143501", "species_113519", "species_113564", "species_76455" ], "modifiers": [ [ "species_10582324", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10588857": { "compartment": "compartment_12045", "id": "reaction_10588857", "reactome": "R-DDI-211966", "name": "CYP2D6 4-hydroxylates debrisoquine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_211993", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211952" ], "modifiers": [ [ "species_10582324", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10582263": { "compartment": "compartment_17960", "id": "reaction_10582263", "reactome": "R-DDI-76354", "name": "Vinyl chloride is oxidized to 2-Chloroethylene oxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_39417", "species_113601" ], "products": [ "species_156524", "species_113519", "species_113564" ], "modifiers": [ [ "species_10582260", "catalyst" ] ], "additional_components": [ "Q1ZXF5", "DDB_G0284535", "Q86A22", "DDB_G0272704", "Q54SK0", "DDB_G0282419", "Q54LA8", "DDB_G0286743", "Q54SV9", "DDB_G0282283", "Q1ZXG3", "DDB_G0282769", "Q54LT7", "DDB_G0286419", "Q1ZXL2", "DDB_G0275197", "Q54ZM4", "DDB_G0277545", "Q54NY3", "DDB_G0284923", "Q556M4", "DDB_G0272604", "Q1ZXL7", "DDB_G0273047", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54CS3", "DDB_G0292792", "Q1ZXA4", "DDB_G0292790", "Q556M5", "DDB_G0273045", "Q54QD0", "DDB_G0283933", "Q55AJ4", "DDB_G0271778", "Q54DT2", "DDB_G0292168", "Q54QD2", "DDB_G0283929", "Q1ZXF3", "DDB_G0284647", "Q54EM5", "DDB_G0291448" ] }, "reaction_10582265": { "compartment": "compartment_17957", "id": "reaction_10582265", "reactome": "R-DDI-76397", "name": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_113564", "species_39427", "species_113555" ], "products": [ "species_113519", "species_76396", "species_113601" ], "modifiers": [ [ "species_10582260", "catalyst" ] ], "additional_components": [ "Q1ZXF5", "DDB_G0284535", "Q86A22", "DDB_G0272704", "Q54SK0", "DDB_G0282419", "Q54LA8", "DDB_G0286743", "Q54SV9", "DDB_G0282283", "Q1ZXG3", "DDB_G0282769", "Q54LT7", "DDB_G0286419", "Q1ZXL2", "DDB_G0275197", "Q54ZM4", "DDB_G0277545", "Q54NY3", "DDB_G0284923", "Q556M4", "DDB_G0272604", "Q1ZXL7", "DDB_G0273047", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54CS3", "DDB_G0292792", "Q1ZXA4", "DDB_G0292790", "Q556M5", "DDB_G0273045", "Q54QD0", "DDB_G0283933", "Q55AJ4", "DDB_G0271778", "Q54DT2", "DDB_G0292168", "Q54QD2", "DDB_G0283929", "Q1ZXF3", "DDB_G0284647", "Q54EM5", "DDB_G0291448" ] }, "reaction_10582329": { "compartment": "compartment_17960", "id": "reaction_10582329", "reactome": "R-DDI-76475", "name": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_40795", "species_113601" ], "products": [ "species_113519", "species_113564", "species_76474", "species_76473" ], "modifiers": [ [ "species_10582260", "catalyst" ] ], "additional_components": [ "Q1ZXF5", "DDB_G0284535", "Q86A22", "DDB_G0272704", "Q54SK0", "DDB_G0282419", "Q54LA8", "DDB_G0286743", "Q54SV9", "DDB_G0282283", "Q1ZXG3", "DDB_G0282769", "Q54LT7", "DDB_G0286419", "Q1ZXL2", "DDB_G0275197", "Q54ZM4", "DDB_G0277545", "Q54NY3", "DDB_G0284923", "Q556M4", "DDB_G0272604", "Q1ZXL7", "DDB_G0273047", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54CS3", "DDB_G0292792", "Q1ZXA4", "DDB_G0292790", "Q556M5", "DDB_G0273045", "Q54QD0", "DDB_G0283933", "Q55AJ4", "DDB_G0271778", "Q54DT2", "DDB_G0292168", "Q54QD2", "DDB_G0283929", "Q1ZXF3", "DDB_G0284647", "Q54EM5", "DDB_G0291448" ] }, "reaction_10582267": { "compartment": "compartment_17960", "id": "reaction_10582267", "reactome": "R-DDI-76416", "name": "Benzene is hydroxylated to phenol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_31711", "species_156540", "species_113601" ], "products": [ "species_113519", "species_29630", "species_113564" ], "modifiers": [ [ "species_10582260", "catalyst" ] ], "additional_components": [ "Q1ZXF5", "DDB_G0284535", "Q86A22", "DDB_G0272704", "Q54SK0", "DDB_G0282419", "Q54LA8", "DDB_G0286743", "Q54SV9", "DDB_G0282283", "Q1ZXG3", "DDB_G0282769", "Q54LT7", "DDB_G0286419", "Q1ZXL2", "DDB_G0275197", "Q54ZM4", "DDB_G0277545", "Q54NY3", "DDB_G0284923", "Q556M4", "DDB_G0272604", "Q1ZXL7", "DDB_G0273047", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54CS3", "DDB_G0292792", "Q1ZXA4", "DDB_G0292790", "Q556M5", "DDB_G0273045", "Q54QD0", "DDB_G0283933", "Q55AJ4", "DDB_G0271778", "Q54DT2", "DDB_G0292168", "Q54QD2", "DDB_G0283929", "Q1ZXF3", "DDB_G0284647", "Q54EM5", "DDB_G0291448" ] }, "reaction_10582269": { "compartment": "compartment_17960", "id": "reaction_10582269", "reactome": "R-DDI-76434", "name": "Dehalogenation of carbon tetrachloride to form a free radical", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_40887" ], "products": [ "species_29572", "species_76433" ], "modifiers": [ [ "species_10582260", "catalyst" ] ], "additional_components": [ "Q1ZXF5", "DDB_G0284535", "Q86A22", "DDB_G0272704", "Q54SK0", "DDB_G0282419", "Q54LA8", "DDB_G0286743", "Q54SV9", "DDB_G0282283", "Q1ZXG3", "DDB_G0282769", "Q54LT7", "DDB_G0286419", "Q1ZXL2", "DDB_G0275197", "Q54ZM4", "DDB_G0277545", "Q54NY3", "DDB_G0284923", "Q556M4", "DDB_G0272604", "Q1ZXL7", "DDB_G0273047", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54CS3", "DDB_G0292792", "Q1ZXA4", "DDB_G0292790", "Q556M5", "DDB_G0273045", "Q54QD0", "DDB_G0283933", "Q55AJ4", "DDB_G0271778", "Q54DT2", "DDB_G0292168", "Q54QD2", "DDB_G0283929", "Q1ZXF3", "DDB_G0284647", "Q54EM5", "DDB_G0291448" ] }, "reaction_10583662": { "compartment": "compartment_17957", "id": "reaction_10583662", "reactome": "R-DDI-143468", "name": "MEOS oxidizes ethanol to acetaldehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113748", "species_113601" ], "products": [ "species_113519", "species_113564", "species_113745" ], "modifiers": [ [ "species_10582260", "catalyst" ] ], "additional_components": [ "Q1ZXF5", "DDB_G0284535", "Q86A22", "DDB_G0272704", "Q54SK0", "DDB_G0282419", "Q54LA8", "DDB_G0286743", "Q54SV9", "DDB_G0282283", "Q1ZXG3", "DDB_G0282769", "Q54LT7", "DDB_G0286419", "Q1ZXL2", "DDB_G0275197", "Q54ZM4", "DDB_G0277545", "Q54NY3", "DDB_G0284923", "Q556M4", "DDB_G0272604", "Q1ZXL7", "DDB_G0273047", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54CS3", "DDB_G0292792", "Q1ZXA4", "DDB_G0292790", "Q556M5", "DDB_G0273045", "Q54QD0", "DDB_G0283933", "Q55AJ4", "DDB_G0271778", "Q54DT2", "DDB_G0292168", "Q54QD2", "DDB_G0283929", "Q1ZXF3", "DDB_G0284647", "Q54EM5", "DDB_G0291448" ] }, "reaction_10588874": { "compartment": "compartment_12045", "id": "reaction_10588874", "reactome": "R-DDI-211991", "name": "Cyclophosphamide is 4-hydroxylated by CYP2B6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_211977", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211967" ], "modifiers": [ [ "species_10588871", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10588796": { "compartment": "compartment_12045", "id": "reaction_10588796", "reactome": "R-DDI-211881", "name": "Coumarin is 7-hydroxylated by CYP2A13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_76328", "species_113601" ], "products": [ "species_113519", "species_113564", "species_76452" ], "modifiers": [ [ "species_10588793", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10588879": { "compartment": "compartment_12045", "id": "reaction_10588879", "reactome": "R-DDI-212004", "name": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_211939" ], "products": [ "species_113519", "species_113564", "species_211927" ], "modifiers": [ [ "species_10588876", "catalyst" ] ], "additional_components": [ "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778" ] }, "reaction_10588791": { "compartment": "compartment_17960", "id": "reaction_10588791", "reactome": "R-DDI-211874", "name": "CYP2S1 4-hydroxylates atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_215573", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215584" ], "modifiers": [ [ "species_10582210", "catalyst" ] ], "additional_components": [ "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778" ] }, "reaction_10588854": { "compartment": "compartment_17960", "id": "reaction_10588854", "reactome": "R-DDI-211960", "name": "CYP2U1 19-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_216620", "species_113519", "species_113564" ], "modifiers": [ [ "species_10588851", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10588862": { "compartment": "compartment_17960", "id": "reaction_10588862", "reactome": "R-DDI-211968", "name": "CYP2W1 oxidises INDOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_216547" ], "products": [ "species_113519", "species_113564", "species_216598" ], "modifiers": [ [ "species_10588859", "catalyst" ] ], "additional_components": [ "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778" ] }, "reaction_10588867": { "compartment": "compartment_17960", "id": "reaction_10588867", "reactome": "R-DDI-211983", "name": "CYP2J2 oxidises ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215062" ], "modifiers": [ [ "species_10588864", "catalyst" ] ], "additional_components": [ "CHEBI:34130", "CHEBI:34157", "species_2142739", "CHEBI:34490", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10585571": { "compartment": "compartment_17957", "id": "reaction_10585571", "reactome": "R-DDI-174931", "name": "UGTs transfer GlcA from UDP-GlcA to O-centre substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174911", "species_174384" ], "products": [ "species_158602", "species_174914" ], "modifiers": [ [ "species_10585568", "catalyst" ] ], "additional_components": [ "species_39427", "CHEBI:16580", "species_211993", "species_29630", "CHEBI:32649", "CHEBI:65137", "CHEBI:64681", "CHEBI:32636", "Q54IL5", "DDB_G0288655", "Q55FB2", "DDB_G0268544", "Q55FX8", "DDB_G0268544", "Q55FY0", "DDB_G0268544" ] }, "reaction_10626273": { "compartment": "compartment_17957", "id": "reaction_10626273", "reactome": "R-DDI-9632039", "name": "UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159151", "species_174384" ], "products": [ "species_159160", "species_158602" ], "modifiers": [ [ "species_10585556", "catalyst" ] ], "additional_components": [ "DDB_G0288655" ] }, "reaction_10585554": { "compartment": "compartment_17957", "id": "reaction_10585554", "reactome": "R-DDI-174916", "name": "Formation of N-glucuronides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174932", "species_174384" ], "products": [ "species_158602", "species_174918" ], "modifiers": [ [ "species_10585551", "catalyst" ] ], "additional_components": [ "species_159154", "CHEBI:17688", "CHEBI:63860", "CHEBI:32663", "Q55FY0", "DDB_G0268544", "Q54IL5", "DDB_G0288655", "Q55FB2", "DDB_G0268544", "Q55FX8", "DDB_G0268544" ] }, "reaction_10623226": { "compartment": "compartment_12045", "id": "reaction_10623226", "reactome": "R-DDI-8941701", "name": "UGT1A10 transfers GlcA from UDP-GlcA to GCTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8941723", "species_174384" ], "products": [ "species_158602", "species_8941725" ], "modifiers": [ [ "species_10585549", "catalyst" ] ], "additional_components": [ "Q54IL5", "DDB_G0288655", "Q55FB2", "DDB_G0268544", "Q55FX8", "DDB_G0268544", "Q55FY0", "DDB_G0268544" ] }, "reaction_10583800": { "compartment": "compartment_17957", "id": "reaction_10583800", "reactome": "R-DDI-159179", "name": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159160", "species_174384" ], "products": [ "species_159149", "species_158602" ], "modifiers": [ [ "species_10583797", "catalyst" ] ], "additional_components": [ "Q55FY0", "DDB_G0268544", "Q54IL5", "DDB_G0288655", "Q55FB2", "DDB_G0268544", "Q55FX8", "DDB_G0268544" ] }, "reaction_10583802": { "compartment": "compartment_17957", "id": "reaction_10583802", "reactome": "R-DDI-159194", "name": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159151", "species_174384" ], "products": [ "species_159160", "species_158602" ], "modifiers": [ [ "species_10583797", "catalyst" ] ], "additional_components": [ "Q55FY0", "DDB_G0268544", "Q54IL5", "DDB_G0288655", "Q55FB2", "DDB_G0268544", "Q55FX8", "DDB_G0268544" ] }, "reaction_10626270": { "compartment": "compartment_17957", "id": "reaction_10626270", "reactome": "R-DDI-9632038", "name": "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159160", "species_174384" ], "products": [ "species_159149", "species_158602" ], "modifiers": [ [ "species_10626267", "catalyst" ] ], "additional_components": [ "Q54IL5", "DDB_G0288655" ] }, "reaction_10611928": { "compartment": "compartment_70101", "id": "reaction_10611928", "reactome": "R-DDI-5696213", "name": "AS3MT transfers CH3 from AdoMet to methylarsonite", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696224", "species_71284" ], "products": [ "species_5696211", "species_71285" ], "modifiers": [ [ "species_10611925", "catalyst" ] ], "additional_components": [ "DDB_G0285905" ] }, "reaction_10605451": { "compartment": "compartment_70101", "id": "reaction_10605451", "reactome": "R-DDI-5603114", "name": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_174390" ], "products": [ "species_111294", "species_29372", "species_71284" ], "modifiers": [ [ "species_10605448", "catalyst" ] ], "additional_components": [ "Q54F07", "DDB_G0291179", "species_29926", "species_74126", "Q54VU3", "DDB_G0280135" ] }, "reaction_10611930": { "compartment": "compartment_70101", "id": "reaction_10611930", "reactome": "R-DDI-5696220", "name": "AS3MT transfers CH3 from AdoMet to arsenite(3-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696216", "species_71284" ], "products": [ "species_71285", "species_5696214" ], "modifiers": [ [ "species_10611925", "catalyst" ] ], "additional_components": [ "DDB_G0285905" ] }, "reaction_10616063": { "compartment": "compartment_70101", "id": "reaction_10616063", "reactome": "R-DDI-6800149", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6806829", "species_71284" ], "products": [ "species_6800127", "species_71285" ], "modifiers": [ [ "species_10616057", "catalyst" ] ], "additional_components": [ "Q54DT3", "DDB_G0292048", "Q54N57", "DDB_G0285489" ] }, "reaction_10623867": { "compartment": "compartment_17963", "id": "reaction_10623867", "reactome": "R-DDI-8953499", "name": "IMPAD1 hydrolyses PAP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742343", "species_2022884" ], "products": [ "species_8851226", "species_8953493" ], "modifiers": [ [ "species_10623864", "catalyst" ], [ "species_8953505", "inhibitor" ] ], "additional_components": [ "species_29926", "Q869K3", "DDB_G0275663" ] }, "reaction_10585754": { "compartment": "compartment_70101", "id": "reaction_10585754", "reactome": "R-DDI-176606", "name": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_158466" ], "products": [ "species_29372", "species_76577" ], "modifiers": [ [ "species_10585751", "catalyst" ] ], "additional_components": [ "DDB_G0275663" ] }, "reaction_10597330": { "compartment": "compartment_70101", "id": "reaction_10597330", "reactome": "R-DDI-1247910", "name": "CNDP2:2Mn2+ dimer hydrolyses CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1247904" ], "products": [ "species_111707", "species_29424" ], "modifiers": [ [ "species_10597327", "catalyst" ] ], "additional_components": [ "species_266099", "Q54X02", "DDB_G0279291" ] }, "reaction_10585509": { "compartment": "compartment_70101", "id": "reaction_10585509", "reactome": "R-DDI-174394", "name": "GSS:Mg2+ dimer synthesizes GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174393", "species_113592", "species_29424" ], "products": [ "species_29372", "species_29370", "species_29450" ], "modifiers": [ [ "species_10585506", "catalyst" ], [ "species_29450", "inhibitor" ] ], "additional_components": [ "Q54E83", "DDB_G0291756", "species_29926" ] }, "reaction_10612601": { "compartment": "compartment_70101", "id": "reaction_10612601", "reactome": "R-DDI-6785928", "name": "CHAC1,2 cleaves GSH to OPRO and CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450" ], "products": [ "species_1247942", "species_1247904" ], "modifiers": [ [ "species_10612598", "catalyst" ] ], "additional_components": [ "Q54LB6", "DDB_G0286727" ] }, "reaction_10597340": { "compartment": "compartment_70101", "id": "reaction_10597340", "reactome": "R-DDI-1247935", "name": "OPLAH hydrolyses OPRO to L-Glu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_1247942" ], "products": [ "species_29372", "species_29404", "species_29370" ], "modifiers": [ [ "species_10597337", "catalyst" ] ], "additional_components": [ "Q54NW6", "DDB_G0284953" ] }, "reaction_10611251": { "compartment": "compartment_70101", "id": "reaction_10611251", "reactome": "R-DDI-5692232", "name": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_5692212" ], "products": [ "species_5692216", "species_29364" ], "modifiers": [ [ "species_10606592", "catalyst" ] ], "additional_components": [ "DDB_G0293850" ] }, "reaction_10585698": { "compartment": "compartment_70101", "id": "reaction_10585698", "reactome": "R-DDI-176054", "name": "GST dimers conjugate GSH with cytosolic substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_176070" ], "products": [ "species_176049" ], "modifiers": [ [ "species_10585695", "catalyst" ] ], "additional_components": [ "species_76396", "CHEBI:34718", "CHEBI:30614", "CHEBI:8927", "CHEBI:32639", "CHEBI:34479", "Q54C73", "DDB_G0293122", "Q86AU1", "DDB_G0274263", "Q556G3", "DDB_G0272632", "Q556P3", "DDB_G0273153", "Q54QV7", "DDB_G0283575", "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "Q54JU2", "DDB_G0287793", "Q54YN2", "DDB_G0278155" ] }, "reaction_10611444": { "compartment": "compartment_17957", "id": "reaction_10611444", "reactome": "R-DDI-5693724", "name": "ESD dimer hydrolyses S-FGSH to GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_5693723" ], "products": [ "species_158543", "species_194712" ], "modifiers": [ [ "species_10611441", "catalyst" ] ], "additional_components": [ "Q54RL8", "DDB_G0283037" ] }, "reaction_10585708": { "compartment": "compartment_17957", "id": "reaction_10585708", "reactome": "R-DDI-176059", "name": "GST trimers transfer GS from GSH to luminal substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158543", "species_176065" ], "products": [ "species_176048" ], "modifiers": [ [ "species_10585705", "catalyst" ] ], "additional_components": [ "species_159211", "CHEBI:27561", "species_76396", "CHEBI:32639", "CHEBI:2505", "CHEBI:35896", "Q54GA9", "DDB_G0290291" ] }, "reaction_10601760": { "compartment": "compartment_5460", "id": "reaction_10601760", "reactome": "R-DDI-2995330", "name": "COX10 transforms heme to heme O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189444", "species_2162257", "species_113521" ], "products": [ "species_2995328", "species_159450" ], "modifiers": [ [ "species_10601757", "catalyst" ] ], "additional_components": [ "DDB_G0288169" ] }, "reaction_10586066": { "compartment": "compartment_70101", "id": "reaction_10586066", "reactome": "R-DDI-189439", "name": "ALAD condenses 2 dALAs to form PBG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189489" ], "products": [ "species_29356", "species_70106", "species_189464" ], "modifiers": [ [ "species_10586063", "catalyst" ] ], "additional_components": [ "species_29426", "Q55E06", "DDB_G0269444" ] }, "reaction_10586084": { "compartment": "compartment_5460", "id": "reaction_10586084", "reactome": "R-DDI-189442", "name": "ALAS condenses SUCC-CoA and Gly to form dALA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_70958", "species_113529" ], "products": [ "species_29374", "species_189466", "species_29376" ], "modifiers": [ [ "species_10586081", "catalyst" ], [ "species_189444", "inhibitor" ] ], "additional_components": [ "Q54UX3", "DDB_G0280763" ] }, "reaction_10586036": { "compartment": "compartment_17927", "id": "reaction_10586036", "reactome": "R-DDI-189421", "name": "CPO transforms COPRO3 to PPGEN9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189461", "species_189411" ], "products": [ "species_189481", "species_189480", "species_189478" ], "modifiers": [ [ "species_10586033", "catalyst" ] ], "additional_components": [ "Q54IA7", "DDB_G0288893" ] }, "reaction_10586102": { "compartment": "compartment_70101", "id": "reaction_10586102", "reactome": "R-DDI-189488", "name": "UROS transforms HMB to URO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189449" ], "products": [ "species_189407", "species_29356" ], "modifiers": [ [ "species_10586099", "catalyst" ] ], "additional_components": [ "DDB_G0285009" ] }, "reaction_10586056": { "compartment": "compartment_70101", "id": "reaction_10586056", "reactome": "R-DDI-189425", "name": "UROD decarboxylates URO3 to COPRO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189407" ], "products": [ "species_189455", "species_113528" ], "modifiers": [ [ "species_10586053", "catalyst" ] ], "additional_components": [ "Q54DF9", "DDB_G0292294" ] }, "reaction_10601768": { "compartment": "compartment_5460", "id": "reaction_10601768", "reactome": "R-DDI-2995334", "name": "COX15 transforms heme O to heme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2995328" ], "products": [ "species_2995348" ], "modifiers": [ [ "species_10601765", "catalyst" ] ], "additional_components": [ "DDB_G0281549" ] }, "reaction_10586106": { "compartment": "compartment_70101", "id": "reaction_10586106", "reactome": "R-DDI-190141", "name": "ALAD binds to Pb2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_190173", "species_10586063" ], "products": [ "species_10586104", "species_29426" ], "modifiers": [], "additional_components": [ "species_29426", "Q55E06", "DDB_G0269444", "species_29426", "Q55E06", "DDB_G0269444", "species_391232" ] }, "reaction_10586108": { "compartment": "compartment_70101", "id": "reaction_10586108", "reactome": "R-DDI-190182", "name": "UROD decarboxylates URO1 to COPRO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_190157" ], "products": [ "species_113528", "species_190128" ], "modifiers": [ [ "species_10586053", "catalyst" ] ], "additional_components": [ "Q54DF9", "DDB_G0292294" ] }, "reaction_10594876": { "compartment": "compartment_876", "id": "reaction_10594876", "reactome": "R-DDI-917979", "name": "ABCG2 tetramer transports heme from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_71185" ], "products": [ "species_29372", "species_917877", "species_29370" ], "modifiers": [ [ "species_10594873", "catalyst" ] ], "additional_components": [ "Q54T02", "DDB_G0282103", "Q8T686", "DDB_G0289655", "Q8T689", "DDB_G0289657", "Q55DA0", "DDB_G0270826", "Q55DW4", "DDB_G0269214", "Q86HQ2", "DDB_G0274117", "Q8T685", "DDB_G0274115" ] }, "reaction_10586046": { "compartment": "compartment_17927", "id": "reaction_10586046", "reactome": "R-DDI-189423", "name": "PPO oxidises PPGEN9 to PRIN9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189461", "species_189478" ], "products": [ "species_189481", "species_189463" ], "modifiers": [ [ "species_10586043", "catalyst" ] ], "additional_components": [ "Q54DT8", "DDB_G0292040", "species_113596" ] }, "reaction_10586094": { "compartment": "compartment_5460", "id": "reaction_10586094", "reactome": "R-DDI-189465", "name": "FECH binds Fe2+ to PRIN9 to form heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189487", "species_113531" ], "products": [ "species_113529", "species_189444" ], "modifiers": [ [ "species_10586091", "catalyst" ], [ "species_391232", "inhibitor" ] ], "additional_components": [ "Q54IA8", "DDB_G0288891" ] }, "reaction_10607713": { "compartment": "compartment_70101", "id": "reaction_10607713", "reactome": "R-DDI-5679041", "name": "ABCC2 transports BMG,BDG from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5679042" ], "products": [ "species_29372", "species_5679034", "species_29370" ], "modifiers": [ [ "species_10597695", "catalyst" ] ], "additional_components": [ "species_159149", "species_159160", "species_159160", "species_159149", "Q54JR2", "DDB_G0287691", "Q54LE6", "DDB_G0286559", "Q54P13", "DDB_G0284867", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977" ] }, "reaction_10627155": { "compartment": "compartment_70101", "id": "reaction_10627155", "reactome": "R-DDI-9663492", "name": "BIL dissociates from GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627153" ], "products": [ "species_189386", "species_10585603" ], "modifiers": [], "additional_components": [ "Q86AU1", "DDB_G0274263", "Q556G3", "DDB_G0272632", "Q556P3", "DDB_G0273153", "Q54QV7", "DDB_G0283575", "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "species_159151", "Q86AU1", "DDB_G0274263", "Q556G3", "DDB_G0272632", "Q556P3", "DDB_G0273153", "Q54QV7", "DDB_G0283575", "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138" ] }, "reaction_10627157": { "compartment": "compartment_70101", "id": "reaction_10627157", "reactome": "R-DDI-9663511", "name": "BIL binds GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189386", "species_10585603" ], "products": [ "species_10627153" ], "modifiers": [], "additional_components": [ "Q86AU1", "DDB_G0274263", "Q556G3", "DDB_G0272632", "Q556P3", "DDB_G0273153", "Q54QV7", "DDB_G0283575", "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "Q86AU1", "DDB_G0274263", "Q556G3", "DDB_G0272632", "Q556P3", "DDB_G0273153", "Q54QV7", "DDB_G0283575", "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "species_159151" ] }, "reaction_10627151": { "compartment": "compartment_70101", "id": "reaction_10627151", "reactome": "R-DDI-9661417", "name": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5679042" ], "products": [ "species_29372", "species_5679034", "species_29370" ], "modifiers": [ [ "species_10594873", "catalyst" ] ], "additional_components": [ "species_159149", "species_159160", "species_159160", "species_159149", "Q54T02", "DDB_G0282103", "Q8T686", "DDB_G0289655", "Q8T689", "DDB_G0289657", "Q55DA0", "DDB_G0270826", "Q55DW4", "DDB_G0269214", "Q86HQ2", "DDB_G0274117", "Q8T685", "DDB_G0274115" ] }, "reaction_10627148": { "compartment": "compartment_70101", "id": "reaction_10627148", "reactome": "R-DDI-9661405", "name": "ABCC1 transports BIL from cytosol to extracellular region (blood)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189386" ], "products": [ "species_9661418" ], "modifiers": [ [ "species_10589142", "catalyst" ] ], "additional_components": [ "Q54JR2", "DDB_G0287691", "Q54LE6", "DDB_G0286559", "Q8ST87", "DDB_G0280977", "Q54P13", "DDB_G0284867", "Q54U44", "DDB_G0280973" ] }, "reaction_10602853": { "compartment": "compartment_7660", "id": "reaction_10602853", "reactome": "R-DDI-3371582", "name": "HSBP1 binds HSF1 trimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602818", "species_10602849" ], "products": [ "species_10602851" ], "modifiers": [], "additional_components": [ "Q54UC1", "DDB_G0281165", "Q556J3", "DDB_G0272620", "Q556J3", "DDB_G0272620", "Q54UC1", "DDB_G0281165" ] }, "reaction_10605031": { "compartment": "compartment_7660", "id": "reaction_10605031", "reactome": "R-DDI-5324617", "name": "HSP90:FKBP4:PTGES3 binds HSF1 trimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602818", "species_10605027" ], "products": [ "species_10605029" ], "modifiers": [], "additional_components": [ "Q54UC1", "DDB_G0281165", "Q54QI6", "DDB_G0283815", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "Q54QI6", "DDB_G0283815", "Q54UC1", "DDB_G0281165", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042" ] }, "reaction_10592388": { "compartment": "compartment_876", "id": "reaction_10592388", "reactome": "R-DDI-435366", "name": "ZnT1 mediates the efflux of zinc from the cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_158417" ], "modifiers": [ [ "species_10592385", "catalyst" ] ], "additional_components": [ "DDB_G0282067" ] }, "reaction_10592414": { "compartment": "compartment_70101", "id": "reaction_10592414", "reactome": "R-DDI-437162", "name": "PI3K alpha, beta, gamma convert PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10590600", "catalyst" ] ], "additional_components": [ "Q54DK0", "DDB_G0292252", "P54675", "DDB_G0275011", "P54673", "DDB_G0278727", "Q54S78", "DDB_G0282625", "Q55FX5", "DDB_G0282625", "P54674", "DDB_G0283081" ] }, "reaction_10581592": { "compartment": "compartment_13231", "id": "reaction_10581592", "reactome": "R-DDI-75823", "name": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581584" ], "products": [ "species_10581590" ], "modifiers": [], "additional_components": [ "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439" ] }, "reaction_10581596": { "compartment": "compartment_70101", "id": "reaction_10581596", "reactome": "R-DDI-75825", "name": "Proteasome mediated degradation of Cyclin D1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581594" ], "products": [ "species_10577037" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10622096": { "compartment": "compartment_171062", "id": "reaction_10622096", "reactome": "R-DDI-8875320", "name": "RAB5 GEFs exchange GTP for GDP on RAB5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10622017" ], "products": [ "species_10621999", "species_29420", "species_10622025" ], "modifiers": [ [ "species_10622093", "catalyst" ] ], "additional_components": [ "Q86JP3", "DDB_G0271984", "species_29420", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q86JP3", "DDB_G0271984", "species_29438", "Q54NU1", "DDB_G0291115", "Q54W41", "DDB_G0291115", "Q54VS5", "DDB_G0291115", "Q55AI4", "DDB_G0291115", "Q55AA6", "DDB_G0291115", "Q54F48", "DDB_G0291115", "Q54HF9", "DDB_G0291115" ] }, "reaction_10622352": { "compartment": "compartment_70101", "id": "reaction_10622352", "reactome": "R-DDI-8876616", "name": "DENND6A,B exchange GTP for GDP on RAB14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10622336" ], "products": [ "species_10621999", "species_29420", "species_10622340" ], "modifiers": [ [ "species_10622349", "catalyst" ] ], "additional_components": [ "species_29420", "P36410", "DDB_G0281337", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "P36410", "DDB_G0281337", "species_29438", "Q54VA9", "DDB_G0280481" ] }, "reaction_10622528": { "compartment": "compartment_171062", "id": "reaction_10622528", "reactome": "R-DDI-8877311", "name": "RAB31 GEFs exchange GTP for GDP on RAB31", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10622519" ], "products": [ "species_10621999", "species_29420", "species_10622523" ], "modifiers": [ [ "species_10622525", "catalyst" ] ], "additional_components": [ "species_29420", "Q8MYF2", "DDB_G0277441", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q8MYF2", "DDB_G0277441", "species_29438", "Q54W41", "DDB_G0291115", "Q54VS5", "DDB_G0291115", "Q55AI4", "DDB_G0291115", "Q55AA6", "DDB_G0291115", "Q54F48", "DDB_G0291115", "Q54NU1", "DDB_G0291115", "Q54HF9", "DDB_G0291115" ] }, "reaction_10622752": { "compartment": "compartment_12045", "id": "reaction_10622752", "reactome": "R-DDI-8877998", "name": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10622739" ], "products": [ "species_10621999", "species_29420", "species_10622743" ], "modifiers": [ [ "species_10622749", "catalyst" ] ], "additional_components": [ "Q54GY8", "DDB_G0289827", "species_29420", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54GY8", "DDB_G0289827", "species_29438", "Q54UJ4", "DDB_G0281043", "Q54DM6", "DDB_G0292124" ] }, "reaction_10622646": { "compartment": "compartment_13946", "id": "reaction_10622646", "reactome": "R-DDI-8877475", "name": "TRAPPC complexes exchange GTP for GDP on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10622591" ], "products": [ "species_10621999", "species_29420", "species_10622619" ], "modifiers": [ [ "species_10622643", "catalyst" ] ], "additional_components": [ "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "P34139", "DDB_G0283757", "species_29420", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "P34139", "DDB_G0283757", "species_29438", "Q54TK7", "DDB_G0281693", "Q54KR2", "DDB_G0287157", "Q54RV6", "DDB_G0282887", "Q54CU7", "DDB_G0292690", "Q54U24", "DDB_G0281351", "Q55EX6", "DDB_G0269062", "Q86K94", "DDB_G0277135", "Q54CV2", "DDB_G0292682", "Q54UU1", "DDB_G0280827", "Q54YG5", "DDB_G0278643", "Q557G3", "DDB_G0273467", "Q555X3", "DDB_G0274803", "Q556Z3", "DDB_G0273209" ] }, "reaction_10622583": { "compartment": "compartment_17938", "id": "reaction_10622583", "reactome": "R-DDI-8877451", "name": "MON1:CCZ1 exchanges GTP for GDP on RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10622534" ], "products": [ "species_10621999", "species_29420", "species_10622564" ], "modifiers": [ [ "species_10622580", "catalyst" ] ], "additional_components": [ "P36411", "DDB_G0269236", "species_29420", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "P36411", "DDB_G0269236", "species_29438", "Q54TG0", "DDB_G0281773", "Q54IQ5", "DDB_G0288589" ] }, "reaction_10622247": { "compartment": "compartment_263163", "id": "reaction_10622247", "reactome": "R-DDI-8876191", "name": "RAB9 GEFs exchange GTP for GDP on RAB9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10622164" ], "products": [ "species_10621999", "species_29420", "species_10622216" ], "modifiers": [ [ "species_10622244", "catalyst" ] ], "additional_components": [ "Q1ZXB9", "DDB_G0290831", "Q54FK7", "DDB_G0290779", "P36411", "DDB_G0269236", "Q54FK2", "DDB_G0290793", "Q54FK8", "DDB_G0290829", "Q1ZXB7", "DDB_G0290791", "Q54FK4", "DDB_G0290833", "Q54K69", "DDB_G0287553", "Q1ZXB8", "DDB_G0294571", "Q54FK5", "DDB_G0290789", "Q552H0", "DDB_G0294571", "species_29420", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54FK5", "DDB_G0290789", "Q54FK4", "DDB_G0290833", "P36411", "DDB_G0269236", "Q54FK8", "DDB_G0290829", "Q54FK7", "DDB_G0290779", "Q1ZXB8", "DDB_G0294571", "Q552H0", "DDB_G0294571", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "Q54FK2", "DDB_G0290793", "Q1ZXB9", "DDB_G0290831", "species_29438", "Q55DD7", "DDB_G0270918" ] }, "reaction_10622260": { "compartment": "compartment_263163", "id": "reaction_10622260", "reactome": "R-DDI-8876193", "name": "RIC1-RGP1 exchanges GTP for GDP on RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10622251" ], "products": [ "species_10621999", "species_29420", "species_10622257" ], "modifiers": [ [ "species_10618445", "catalyst" ] ], "additional_components": [ "species_29420", "Q55FK2", "DDB_G0268068", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "species_29438", "Q55FK2", "DDB_G0268068", "Q54WR7", "DDB_G0279477", "Q76NU4", "DDB_G0277397" ] }, "reaction_10622709": { "compartment": "compartment_5668575", "id": "reaction_10622709", "reactome": "R-DDI-8877760", "name": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10622680" ], "products": [ "species_10621999", "species_29420", "species_10622694" ], "modifiers": [ [ "species_10622706", "catalyst" ] ], "additional_components": [ "Q54QR3", "DDB_G0283603", "Q8MXQ2", "DDB_G0275675", "Q1ZXC0", "DDB_G0290827", "species_29420", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q8MXQ2", "DDB_G0275675", "Q54QR3", "DDB_G0283603", "Q1ZXC0", "DDB_G0290827", "species_29438", "Q55FG6", "DDB_G0268126", "Q54M79", "DDB_G0286137" ] }, "reaction_10622442": { "compartment": "compartment_171062", "id": "reaction_10622442", "reactome": "R-DDI-8876837", "name": "RAB21 GEFs exchange GTP for GDP on RAB21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10622376" ], "products": [ "species_10622380", "species_10621999", "species_29420" ], "modifiers": [ [ "species_10622439", "catalyst" ] ], "additional_components": [ "P34142", "DDB_G0286553", "species_29420", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "P34142", "DDB_G0286553", "species_29438", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54PZ6", "DDB_G0284213", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54TD5", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258" ] }, "reaction_10624461": { "compartment": "compartment_5460", "id": "reaction_10624461", "reactome": "R-DDI-8986181", "name": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624453" ], "products": [], "modifiers": [ [ "species_10624458", "catalyst" ] ], "additional_components": [ "Q54QH7", "DDB_G0283889", "DDB_G0271506" ] }, "reaction_10577280": { "compartment": "compartment_7660", "id": "reaction_10577280", "reactome": "R-DDI-69006", "name": "Phosphorylated Cdc6 is exported from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577255" ], "products": [ "species_10577278" ], "modifiers": [], "additional_components": [ "DDB_G0275983", "DDB_G0275983" ] }, "reaction_10577387": { "compartment": "compartment_70101", "id": "reaction_10577387", "reactome": "R-DDI-69015", "name": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577278", "species_10577037", "species_113592" ], "products": [ "species_10577284" ], "modifiers": [ [ "species_10577384", "catalyst" ] ], "additional_components": [ "DDB_G0275983", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q552L8", "DDB_G0275983", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54KM3", "DDB_G0287259" ] }, "reaction_10577389": { "compartment": "compartment_70101", "id": "reaction_10577389", "reactome": "R-DDI-69016", "name": "Ubiquitinated Cdc6 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577284" ], "products": [ "species_10577037" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q552L8", "DDB_G0275983", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10577276": { "compartment": "compartment_7660", "id": "reaction_10577276", "reactome": "R-DDI-69005", "name": "Cdc6 protein is phosphorylated by CDK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10576515" ], "products": [ "species_113582", "species_10577255" ], "modifiers": [ [ "species_10577273", "catalyst" ] ], "additional_components": [ "DDB_G0275983", "DDB_G0275983", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493" ] }, "reaction_10577393": { "compartment": "compartment_7660", "id": "reaction_10577393", "reactome": "R-DDI-69019", "name": "Mcm4,6,7 trimer forms and associates with the replication fork", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576576" ], "products": [ "species_10576574", "species_10577391", "species_10576559", "species_10576549" ], "modifiers": [], "additional_components": [ "Q54VI9", "DDB_G0280309", "Q86B14", "DDB_G0272760", "Q54RU0", "DDB_G0282933", "Q86IF1", "DDB_G0275623", "Q54CP4", "DDB_G0292958", "Q54LI2", "DDB_G0286623", "DDB_G0286623", "Q86B14", "DDB_G0272760", "Q54RU0", "DDB_G0282933", "Q86IF1", "DDB_G0275623", "DDB_G0292958", "DDB_G0280309" ] }, "reaction_10576897": { "compartment": "compartment_7660", "id": "reaction_10576897", "reactome": "R-DDI-68946", "name": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576678", "species_10576865" ], "products": [ "species_10576868" ], "modifiers": [ [ "species_10576894", "catalyst" ] ], "additional_components": [ "DDB_G0283073", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0283073", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54K33", "DDB_G0287629" ] }, "reaction_10576901": { "compartment": "compartment_7660", "id": "reaction_10576901", "reactome": "R-DDI-68947", "name": "Ubiquitinated Orc1 enters the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576868" ], "products": [ "species_10576899" ], "modifiers": [], "additional_components": [ "DDB_G0283073", "DDB_G0283073" ] }, "reaction_10576708": { "compartment": "compartment_7660", "id": "reaction_10576708", "reactome": "R-DDI-68944", "name": "Orc1 is phosphorylated by cyclin A/CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10576578" ], "products": [ "species_113582", "species_10576680", "species_10576678" ], "modifiers": [ [ "species_10576705", "catalyst" ] ], "additional_components": [ "Q552L8", "DDB_G0275983", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q54RN8", "DDB_G0283009", "Q86AD6", "DDB_G0271562", "Q54P62", "DDB_G0284771", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "Q54VI9", "DDB_G0280309", "Q86B14", "DDB_G0272760", "Q54RU0", "DDB_G0282933", "Q86IF1", "DDB_G0275623", "Q54CP4", "DDB_G0292958", "Q54LI2", "DDB_G0286623", "Q54VI9", "DDB_G0280309", "Q86B14", "DDB_G0272760", "Q54RU0", "DDB_G0282933", "Q86IF1", "DDB_G0275623", "Q54CP4", "DDB_G0292958", "Q54LI2", "DDB_G0286623", "Q552L8", "DDB_G0275983", "Q55CU7", "DDB_G0269894", "Q54RN8", "DDB_G0283009", "Q86AD6", "DDB_G0271562", "Q54P62", "DDB_G0284771", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "DDB_G0283073", "P34112", "DDB_G0272813" ] }, "reaction_10577243": { "compartment": "compartment_70101", "id": "reaction_10577243", "reactome": "R-DDI-68948", "name": "Ubiquitinated Orc1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576899" ], "products": [ "species_10577037" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "DDB_G0283073", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10585789": { "compartment": "compartment_7660", "id": "reaction_10585789", "reactome": "R-DDI-176956", "name": "Formation of GINS complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585775", "species_10585770", "species_10585785", "species_10585780" ], "products": [ "species_10585787" ], "modifiers": [], "additional_components": [ "DDB_G0293564", "DDB_G0289271", "DDB_G0269324", "DDB_G0291506", "Q54EH6", "DDB_G0291506", "Q55EA2", "DDB_G0269324", "Q54HR6", "DDB_G0289271", "Q54BL9", "DDB_G0293564" ] }, "reaction_10577248": { "compartment": "compartment_7660", "id": "reaction_10577248", "reactome": "R-DDI-68950", "name": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30187", "species_10576632", "species_30185", "species_29892", "species_29604" ], "products": [ "species_10577245" ], "modifiers": [ [ "species_10576604", "catalyst" ] ], "additional_components": [ "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731" ] }, "reaction_10576635": { "compartment": "compartment_7660", "id": "reaction_10576635", "reactome": "R-DDI-68913", "name": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576630", "species_30595" ], "products": [ "species_10576632", "species_10576626" ], "modifiers": [ [ "species_10576630", "catalyst" ] ], "additional_components": [ "Q54RD4", "DDB_G0283189", "Q7KWN0", "DDB_G0272740", "Q54Y85", "DDB_G0278367", "Q75JQ9", "DDB_G0272222", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "species_110614", "species_113592", "species_29494", "species_29438", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54RD4", "DDB_G0283189", "Q7KWN0", "DDB_G0272740", "Q54Y85", "DDB_G0278367", "Q75JQ9", "DDB_G0272222", "Q54RD4", "DDB_G0283189", "Q7KWN0", "DDB_G0272740", "Q54Y85", "DDB_G0278367", "Q75JQ9", "DDB_G0272222", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731" ] }, "reaction_10576580": { "compartment": "compartment_7660", "id": "reaction_10576580", "reactome": "R-DDI-68849", "name": "Mcm2-7 associates with the Cdt1:CDC6:ORC:origin complex, forming the pre-replicative complex (preRC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576576", "species_10576544" ], "products": [ "species_10576578" ], "modifiers": [], "additional_components": [ "Q54VI9", "DDB_G0280309", "Q86B14", "DDB_G0272760", "Q54RU0", "DDB_G0282933", "Q86IF1", "DDB_G0275623", "Q54CP4", "DDB_G0292958", "Q54LI2", "DDB_G0286623", "Q552L8", "DDB_G0275983", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q54RN8", "DDB_G0283009", "Q86AD6", "DDB_G0271562", "Q54P62", "DDB_G0284771", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "Q552L8", "DDB_G0275983", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q54RN8", "DDB_G0283009", "Q86AD6", "DDB_G0271562", "Q54P62", "DDB_G0284771", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "Q54VI9", "DDB_G0280309", "Q86B14", "DDB_G0272760", "Q54RU0", "DDB_G0282933", "Q86IF1", "DDB_G0275623", "Q54CP4", "DDB_G0292958", "Q54LI2", "DDB_G0286623" ] }, "reaction_10585791": { "compartment": "compartment_7660", "id": "reaction_10585791", "reactome": "R-DDI-176973", "name": "Association of MCM8 with ORC:origin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576508", "species_10576532" ], "products": [ "species_10576536" ], "modifiers": [], "additional_components": [ "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q86AD6", "DDB_G0271562", "Q54P62", "DDB_G0284771", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "DDB_G0283009", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q54RN8", "DDB_G0283009", "Q86AD6", "DDB_G0271562", "Q54P62", "DDB_G0284771", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214" ] }, "reaction_10576540": { "compartment": "compartment_7660", "id": "reaction_10576540", "reactome": "R-DDI-68688", "name": "CDC6 association with ORC:origin complexes mediated by MCM8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576536", "species_10576515" ], "products": [ "species_10576538" ], "modifiers": [], "additional_components": [ "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q54RN8", "DDB_G0283009", "Q86AD6", "DDB_G0271562", "Q54P62", "DDB_G0284771", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "DDB_G0275983", "Q552L8", "DDB_G0275983", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q54RN8", "DDB_G0283009", "Q86AD6", "DDB_G0271562", "Q54P62", "DDB_G0284771", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214" ] }, "reaction_10576526": { "compartment": "compartment_7660", "id": "reaction_10576526", "reactome": "R-DDI-68637", "name": "CDC6 protein is synthesized under the control of E2F transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10576515" ], "modifiers": [ [ "species_10576524", "catalyst" ] ], "additional_components": [ "DDB_G0275983", "Q54Q23", "DDB_G0284129" ] }, "reaction_10576672": { "compartment": "compartment_7660", "id": "reaction_10576672", "reactome": "R-DDI-68917", "name": "Cdc45 associates with the pre-replicative complex at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576668", "species_10576642" ], "products": [ "species_10576670" ], "modifiers": [], "additional_components": [ "Q54DK3", "DDB_G0292152", "P34112", "DDB_G0272813", "Q54VI9", "DDB_G0280309", "Q86B14", "DDB_G0272760", "Q54RU0", "DDB_G0282933", "Q86IF1", "DDB_G0275623", "Q54CP4", "DDB_G0292958", "Q54LI2", "DDB_G0286623", "Q552L8", "DDB_G0275983", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q54RN8", "DDB_G0283009", "Q86AD6", "DDB_G0271562", "Q54P62", "DDB_G0284771", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "DDB_G0267748", "Q55GA4", "DDB_G0267748", "Q54DK3", "DDB_G0292152", "P34112", "DDB_G0272813", "Q54VI9", "DDB_G0280309", "Q86B14", "DDB_G0272760", "Q54RU0", "DDB_G0282933", "Q86IF1", "DDB_G0275623", "Q54CP4", "DDB_G0292958", "Q54LI2", "DDB_G0286623", "Q552L8", "DDB_G0275983", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q54RN8", "DDB_G0283009", "Q86AD6", "DDB_G0271562", "Q54P62", "DDB_G0284771", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214" ] }, "reaction_10577252": { "compartment": "compartment_7660", "id": "reaction_10577252", "reactome": "R-DDI-68960", "name": "DNA polymerase epsilon binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576626", "species_68419" ], "products": [ "species_10576628" ], "modifiers": [], "additional_components": [ "Q54RD4", "DDB_G0283189", "Q7KWN0", "DDB_G0272740", "Q54Y85", "DDB_G0278367", "Q75JQ9", "DDB_G0272222", "Q54RD4", "DDB_G0283189", "Q7KWN0", "DDB_G0272740", "Q54Y85", "DDB_G0278367", "Q75JQ9", "DDB_G0272222" ] }, "reaction_10576637": { "compartment": "compartment_7660", "id": "reaction_10576637", "reactome": "R-DDI-68914", "name": "DNA polymerase alpha:primase binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576604", "species_10576628" ], "products": [ "species_10576630" ], "modifiers": [], "additional_components": [ "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54RD4", "DDB_G0283189", "Q7KWN0", "DDB_G0272740", "Q54Y85", "DDB_G0278367", "Q75JQ9", "DDB_G0272222", "Q54RD4", "DDB_G0283189", "Q7KWN0", "DDB_G0272740", "Q54Y85", "DDB_G0278367", "Q75JQ9", "DDB_G0272222", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731" ] }, "reaction_10589187": { "compartment": "compartment_7660", "id": "reaction_10589187", "reactome": "R-DDI-266204", "name": "Association of HMGB1/HMGB2 with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589181", "species_29428" ], "products": [ "species_10589185" ], "modifiers": [], "additional_components": [ "DDB_G0270260", "Q55C24", "DDB_G0270260" ] }, "reaction_10589444": { "compartment": "compartment_70101", "id": "reaction_10589444", "reactome": "R-DDI-351948", "name": "Mitochondrial recruitment of Drp1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589436" ], "products": [ "species_10589442" ], "modifiers": [ [ "species_10589400", "catalyst" ] ], "additional_components": [ "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "DDB_G0287543" ] }, "reaction_10589430": { "compartment": "compartment_13231", "id": "reaction_10589430", "reactome": "R-DDI-351947", "name": "Nuclear translocation of catalytic domain of Mst3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589416" ], "products": [ "species_10589428" ], "modifiers": [], "additional_components": [ "O61122", "DDB_G0286359", "Q54DC8", "DDB_G0292350", "O61122", "DDB_G0286359", "Q54DC8", "DDB_G0292350" ] }, "reaction_10601347": { "compartment": "compartment_70101", "id": "reaction_10601347", "reactome": "R-DDI-2529020", "name": "CK2 phosphorylates condensin I subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10601313" ], "products": [ "species_29370", "species_10601303" ], "modifiers": [ [ "species_10601344", "catalyst" ] ], "additional_components": [ "Q54PK4", "DDB_G0284499", "Q54B17", "DDB_G0293984", "Q54DR4", "DDB_G0292066", "Q54WY1", "DDB_G0279329", "Q54LV0", "DDB_G0286403", "Q54DR4", "DDB_G0292066", "Q54LV0", "DDB_G0286403", "Q54PK4", "DDB_G0284499", "Q54B17", "DDB_G0293984", "Q54WY1", "DDB_G0279329", "Q54PF1", "DDB_G0284601", "Q02720", "DDB_G0276885", "Q54LR6", "DDB_G0286481" ] }, "reaction_10601315": { "compartment": "compartment_70101", "id": "reaction_10601315", "reactome": "R-DDI-2529015", "name": "Dephosphorylation of CK2-modified condensin I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10601303" ], "products": [ "species_29372", "species_10601313" ], "modifiers": [ [ "species_2529006", "catalyst" ] ], "additional_components": [ "Q54DR4", "DDB_G0292066", "Q54LV0", "DDB_G0286403", "Q54PK4", "DDB_G0284499", "Q54B17", "DDB_G0293984", "Q54WY1", "DDB_G0279329", "Q54PK4", "DDB_G0284499", "Q54B17", "DDB_G0293984", "Q54DR4", "DDB_G0292066", "Q54WY1", "DDB_G0279329", "Q54LV0", "DDB_G0286403" ] }, "reaction_10605458": { "compartment": "compartment_876", "id": "reaction_10605458", "reactome": "R-DDI-5610727", "name": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_111294", "species_30389" ], "modifiers": [ [ "species_10605455", "catalyst" ] ], "additional_components": [ "species_29926" ] }, "reaction_10605510": { "compartment": "compartment_5263228", "id": "reaction_10605510", "reactome": "R-DDI-5610733", "name": "KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605506", "species_10605504" ], "products": [ "species_10605508" ], "modifiers": [], "additional_components": [ "DDB_G0284471", "species_29420", "species_29438", "species_29420", "species_29438", "Q6S003", "DDB_G0284471" ] }, "reaction_10605534": { "compartment": "compartment_5263232", "id": "reaction_10605534", "reactome": "R-DDI-5610749", "name": "cAMP dissociates PKA, promoting GLI processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605530", "species_30389" ], "products": [ "species_10605518", "species_10605532" ], "modifiers": [], "additional_components": [ "P05987", "DDB_G0279413", "Q8MM62", "DDB_G0276027", "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029", "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029", "species_30389", "P05987", "DDB_G0279413", "Q8MM62", "DDB_G0276027" ] }, "reaction_10580620": { "compartment": "compartment_7660", "id": "reaction_10580620", "reactome": "R-DDI-73757", "name": "Binding of RRN3 to RNA Polymerase I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580616", "species_10580611" ], "products": [ "species_10580618" ], "modifiers": [], "additional_components": [ "DDB_G0289587", "Q54YF5", "DDB_G0278263", "Q54R66", "DDB_G0283365", "Q54EH2", "DDB_G0291636", "Q54BM1", "DDB_G0293560", "Q54SN4", "DDB_G0282339", "Q54FA8", "DDB_G0291037", "Q55AB6", "DDB_G0272036", "Q86H36", "DDB_G0275759", "Q54FE8", "DDB_G0290909", "Q54YW8", "DDB_G0278039", "Q55FA4", "DDB_G0268198", "Q54YF5", "DDB_G0278263", "Q54R66", "DDB_G0283365", "Q54EH2", "DDB_G0291636", "Q54BM1", "DDB_G0293560", "Q54SN4", "DDB_G0282339", "Q54FA8", "DDB_G0291037", "Q55AB6", "DDB_G0272036", "Q86H36", "DDB_G0275759", "Q54FE8", "DDB_G0290909", "Q54YW8", "DDB_G0278039", "Q55FA4", "DDB_G0268198", "Q54HB0", "DDB_G0289587" ] }, "reaction_10581489": { "compartment": "compartment_350", "id": "reaction_10581489", "reactome": "R-DDI-74986", "name": "Elongation of pre-rRNA transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74985", "species_30595" ], "products": [ "species_74985" ], "modifiers": [ [ "species_10580705", "catalyst" ], [ "species_10581487", "catalyst" ] ], "additional_components": [ "species_110614", "species_113592", "species_29494", "species_29438", "Q54YF5", "DDB_G0278263", "Q54R66", "DDB_G0283365", "Q54EH2", "DDB_G0291636", "Q54BM1", "DDB_G0293560", "Q54SN4", "DDB_G0282339", "Q54FA8", "DDB_G0291037", "Q55AB6", "DDB_G0272036", "Q86H36", "DDB_G0275759", "Q54FE8", "DDB_G0290909", "Q54YW8", "DDB_G0278039", "Q55FA4", "DDB_G0268198", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q554V6", "DDB_G0274953", "P26355", "DDB_G0275617", "Q55C69", "DDB_G0270198", "Q54RN0", "DDB_G0283023", "Q54RQ4", "DDB_G0283023", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863" ] }, "reaction_10580707": { "compartment": "compartment_7660", "id": "reaction_10580707", "reactome": "R-DDI-73769", "name": "Loss of Rrn3 from RNA Polymerase I promoter escape complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580701" ], "products": [ "species_10580616", "species_10580705" ], "modifiers": [], "additional_components": [ "Q554V6", "DDB_G0274953", "P26355", "DDB_G0275617", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54YF5", "DDB_G0278263", "Q54R66", "DDB_G0283365", "Q54EH2", "DDB_G0291636", "Q54BM1", "DDB_G0293560", "Q54SN4", "DDB_G0282339", "Q54FA8", "DDB_G0291037", "Q55AB6", "DDB_G0272036", "Q86H36", "DDB_G0275759", "Q54FE8", "DDB_G0290909", "Q54YW8", "DDB_G0278039", "Q55FA4", "DDB_G0268198", "Q54HB0", "DDB_G0289587", "DDB_G0289587", "Q54YF5", "DDB_G0278263", "Q54R66", "DDB_G0283365", "Q54EH2", "DDB_G0291636", "Q54BM1", "DDB_G0293560", "Q54SN4", "DDB_G0282339", "Q54FA8", "DDB_G0291037", "Q55AB6", "DDB_G0272036", "Q86H36", "DDB_G0275759", "Q54FE8", "DDB_G0290909", "Q54YW8", "DDB_G0278039", "Q55FA4", "DDB_G0268198", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q554V6", "DDB_G0274953", "P26355", "DDB_G0275617" ] }, "reaction_10590390": { "compartment": "compartment_70101", "id": "reaction_10590390", "reactome": "R-DDI-389788", "name": "Activation of PAKs by RAC1 and CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583374", "species_10590384" ], "products": [ "species_10590388", "species_10590386" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459", "P34144", "DDB_G0277869", "species_29438", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459" ] }, "reaction_10592081": { "compartment": "compartment_70101", "id": "reaction_10592081", "reactome": "R-DDI-432232", "name": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10592069" ], "products": [ "species_10592079", "species_29370" ], "modifiers": [ [ "species_10582991", "catalyst" ] ], "additional_components": [ "Q9U8P7", "DDB_G0267378", "Q54FQ9", "DDB_G0290691", "Q54V53", "DDB_G0280537", "Q54FQ9", "DDB_G0290691", "Q54V53", "DDB_G0280537", "Q9U8P7", "DDB_G0267378", "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029" ] }, "reaction_10592022": { "compartment": "compartment_876", "id": "reaction_10592022", "reactome": "R-DDI-432010", "name": "Aquaporin-1 passively transports water into cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10592019", "catalyst" ] ], "additional_components": [ "Q9U8P7", "DDB_G0267378" ] }, "reaction_10592024": { "compartment": "compartment_876", "id": "reaction_10592024", "reactome": "R-DDI-432054", "name": "Aquaporin-1 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10592019", "catalyst" ] ], "additional_components": [ "Q9U8P7", "DDB_G0267378" ] }, "reaction_10592059": { "compartment": "compartment_876", "id": "reaction_10592059", "reactome": "R-DDI-432067", "name": "Aquaporin-4 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10592056", "catalyst" ] ], "additional_components": [ "Q54FQ9", "DDB_G0290691", "Q54V53", "DDB_G0280537", "Q9U8P7", "DDB_G0267378" ] }, "reaction_10592046": { "compartment": "compartment_876", "id": "reaction_10592046", "reactome": "R-DDI-432065", "name": "p-S256-Aquaporin-2 passively transports water into cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10592043", "catalyst" ] ], "additional_components": [ "Q54V53", "DDB_G0280537", "Q9U8P7", "DDB_G0267378", "Q54FQ9", "DDB_G0290691" ] }, "reaction_10625623": { "compartment": "compartment_70101", "id": "reaction_10625623", "reactome": "R-DDI-9029987", "name": "p-S216-CDC25C translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581495" ], "products": [ "species_10581499" ], "modifiers": [], "additional_components": [ "DDB_G0283617", "DDB_G0283617" ] }, "reaction_10581576": { "compartment": "compartment_7660", "id": "reaction_10581576", "reactome": "R-DDI-75809", "name": "Phosphorylation of Cdc25C at Ser216 by CHEK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10581492" ], "products": [ "species_113582", "species_10581495" ], "modifiers": [ [ "species_10577617", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "DDB_G0280321" ] }, "reaction_10608080": { "compartment": "compartment_7660", "id": "reaction_10608080", "reactome": "R-DDI-5683774", "name": "p-T68-CHEK2 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608076" ], "products": [ "species_10608078" ], "modifiers": [], "additional_components": [ "DDB_G0280321", "Q54VI1", "DDB_G0280321" ] }, "reaction_10608083": { "compartment": "compartment_7660", "id": "reaction_10608083", "reactome": "R-DDI-5683792", "name": "p-T68-CHEK2 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608078", "species_29358" ], "products": [ "species_113582", "species_10577617" ], "modifiers": [ [ "species_10608078", "catalyst" ] ], "additional_components": [ "Q54VI1", "DDB_G0280321", "DDB_G0280321", "Q54VI1", "DDB_G0280321" ] }, "reaction_10581497": { "compartment": "compartment_7660", "id": "reaction_10581497", "reactome": "R-DDI-75010", "name": "Phosphorylation of Cdc25C at Ser 216 by Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10581492" ], "products": [ "species_113582", "species_10581495" ], "modifiers": [ [ "species_10577605", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "DDB_G0279719" ] }, "reaction_10601585": { "compartment": "compartment_70101", "id": "reaction_10601585", "reactome": "R-DDI-2730872", "name": "Activation of Calcineurin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599837", "species_10583042", "species_74016" ], "products": [ "species_10601542" ], "modifiers": [], "additional_components": [ "Q55G87", "DDB_G0267446", "species_29426", "Q7YSW8", "DDB_G0276883", "CHEBI:29034", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "species_74112", "Q55G87", "DDB_G0267446", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "species_29426", "Q7YSW8", "DDB_G0276883", "CHEBI:29034" ] }, "reaction_10601566": { "compartment": "compartment_70101", "id": "reaction_10601566", "reactome": "R-DDI-2730867", "name": "Translocation of CaN:CaM:NFAT to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601546" ], "products": [ "species_10601564" ], "modifiers": [], "additional_components": [ "species_74112", "Q55G87", "DDB_G0267446", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "species_29426", "Q7YSW8", "DDB_G0276883", "CHEBI:29034", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "species_74112", "Q7YSW8", "DDB_G0276883", "CHEBI:29034", "species_29426", "Q55G87", "DDB_G0267446" ] }, "reaction_10605809": { "compartment": "compartment_876", "id": "reaction_10605809", "reactome": "R-DDI-5624494", "name": "RAF1 binds p21 RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590651", "species_10585144" ], "products": [ "species_10605804" ], "modifiers": [], "additional_components": [ "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54TM7", "DDB_G0281557" ] }, "reaction_10605807": { "compartment": "compartment_876", "id": "reaction_10605807", "reactome": "R-DDI-5624492", "name": "PAK phosphorylates p21 RAF1 on S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605804", "species_113592" ], "products": [ "species_29370", "species_10605796" ], "modifiers": [ [ "species_10590386", "catalyst" ] ], "additional_components": [ "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54TM7", "DDB_G0281557", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459" ] }, "reaction_10605769": { "compartment": "compartment_70101", "id": "reaction_10605769", "reactome": "R-DDI-5618331", "name": "HDAC6 deacetylates microtubules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605766", "species_76194" ], "products": [ "species_10589898", "species_76183" ], "modifiers": [ [ "species_10605033", "catalyst" ] ], "additional_components": [ "species_29438", "species_29420", "species_29438", "species_29420", "DDB_G0279267" ] }, "reaction_10608705": { "compartment": "compartment_5460", "id": "reaction_10608705", "reactome": "R-DDI-5688289", "name": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_10608691" ], "products": [ "species_5688337", "species_10608695", "species_5688274" ], "modifiers": [ [ "species_10608702", "catalyst" ] ], "additional_components": [ "Q55BJ9", "DDB_G0271106", "Q54Z60", "DDB_G0277815", "Q54KB7", "DDB_G0287469", "Q54KB7", "DDB_G0287469", "Q54Z60", "DDB_G0277815", "Q55BJ9", "DDB_G0271106", "Q54LF0", "DDB_G0286671", "species_29426" ] }, "reaction_10608718": { "compartment": "compartment_17927", "id": "reaction_10608718", "reactome": "R-DDI-5688294", "name": "SIRT5 deacetylates Cytochrome C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5688282", "species_10608708" ], "products": [ "species_5688281", "species_10583365", "species_5688340" ], "modifiers": [ [ "species_10608715", "catalyst" ] ], "additional_components": [ "DDB_G0275537", "DDB_G0275537", "species_29426", "Q55DB0", "DDB_G0270928" ] }, "reaction_10624307": { "compartment": "compartment_876", "id": "reaction_10624307", "reactome": "R-DDI-8982019", "name": "Active G alpha (i)i1/i2/i3 binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584927", "species_10624289" ], "products": [ "species_10624305" ], "modifiers": [], "additional_components": [ "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438" ] }, "reaction_10585810": { "compartment": "compartment_70101", "id": "reaction_10585810", "reactome": "R-DDI-177284", "name": "PKA phosphorylates PDE4B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10585799" ], "products": [ "species_10585807", "species_29370" ], "modifiers": [ [ "species_10582991", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121", "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121", "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029" ] }, "reaction_10626513": { "compartment": "compartment_70101", "id": "reaction_10626513", "reactome": "R-DDI-9644869", "name": "p-S54-PDE4B hydrolyses cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10585807", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121" ] }, "reaction_10583101": { "compartment": "compartment_70101", "id": "reaction_10583101", "reactome": "R-DDI-111962", "name": "PDE4A,C,D hydrolyse cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10583098", "catalyst" ] ], "additional_components": [ "Q86H13", "DDB_G0289121", "Q23917", "DDB_G0284331" ] }, "reaction_10584502": { "compartment": "compartment_947587", "id": "reaction_10584502", "reactome": "R-DDI-167415", "name": "G-protein alpha subunit is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29420", "species_10582953" ], "products": [ "species_29438", "species_10583103" ], "modifiers": [ [ "species_10582951", "catalyst" ] ], "additional_components": [ "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29420", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351" ] }, "reaction_10584945": { "compartment": "compartment_876", "id": "reaction_10584945", "reactome": "R-DDI-170672", "name": "Galpha-olf:GTP binds to adenylate cyclase and activates it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583022", "species_10584867" ], "products": [ "species_10584942" ], "modifiers": [ [ "species_10583022", "catalyst" ] ], "additional_components": [ "species_29926", "Q03100", "DDB_G0281545", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545", "species_29926", "Q03100", "DDB_G0281545" ] }, "reaction_10584961": { "compartment": "compartment_876", "id": "reaction_10584961", "reactome": "R-DDI-170685", "name": "Adenylaye cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584942" ], "products": [ "species_10584956", "species_29372" ], "modifiers": [ [ "species_10584942", "catalyst" ] ], "additional_components": [ "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29420", "species_29926", "Q03100", "DDB_G0281545", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545" ] }, "reaction_10584954": { "compartment": "compartment_876", "id": "reaction_10584954", "reactome": "R-DDI-170676", "name": "Adenylate cyclase converts ATP into cyclic AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_111294", "species_30389" ], "modifiers": [ [ "species_10584942", "catalyst" ] ], "additional_components": [ "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545" ] }, "reaction_10584958": { "compartment": "compartment_876", "id": "reaction_10584958", "reactome": "R-DDI-170677", "name": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584956" ], "products": [ "species_10583022", "species_10584933" ], "modifiers": [], "additional_components": [ "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29420", "species_29926", "Q03100", "DDB_G0281545", "species_29926", "Q03100", "DDB_G0281545", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29420" ] }, "reaction_10589829": { "compartment": "compartment_947587", "id": "reaction_10589829", "reactome": "R-DDI-380073", "name": "Liganded Gi-activating GPCR acts as a GEF for Gi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589822", "species_29438" ], "products": [ "species_29420", "species_10589826" ], "modifiers": [ [ "species_10589822", "catalyst" ] ], "additional_components": [ "species_916850", "Q54F54", "DDB_G0291095", "Q54K09", "DDB_G0287905", "Q54ET0", "DDB_G0291356", "species_29420", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P36408", "DDB_G0277143", "P36408", "DDB_G0277143", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_916850", "Q54F54", "DDB_G0291095", "Q54K09", "DDB_G0287905", "Q54ET0", "DDB_G0291356", "species_916850", "Q54F54", "DDB_G0291095", "Q54K09", "DDB_G0287905", "Q54ET0", "DDB_G0291356", "species_29420", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P36408", "DDB_G0277143" ] }, "reaction_10624310": { "compartment": "compartment_876", "id": "reaction_10624310", "reactome": "R-DDI-8982020", "name": "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624305" ], "products": [ "species_29372", "species_10624291" ], "modifiers": [ [ "species_10624305", "catalyst" ] ], "additional_components": [ "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29420", "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438" ] }, "reaction_10624293": { "compartment": "compartment_876", "id": "reaction_10624293", "reactome": "R-DDI-8982012", "name": "G alpha (i):RGS dissociates to inactive G alpha (i)i1/i2/i3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624291" ], "products": [ "species_10624289", "species_10584947" ], "modifiers": [], "additional_components": [ "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29420", "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "species_29420", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343" ] }, "reaction_10601449": { "compartment": "compartment_876", "id": "reaction_10601449", "reactome": "R-DDI-2534365", "name": "Slo3 Potassium Transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10601446", "catalyst" ] ], "additional_components": [ "Q55CU6", "DDB_G0269896", "Q54SN1", "DDB_G0282291" ] }, "reaction_10583314": { "compartment": "compartment_7660", "id": "reaction_10583314", "reactome": "R-DDI-113407", "name": "DSIF complex binds to RNA Pol II (hypophosphorylated)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583215", "species_10583165" ], "products": [ "species_10583217" ], "modifiers": [], "additional_components": [ "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q75JA4", "DDB_G0271690", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q75JA4", "DDB_G0271690", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10583222": { "compartment": "compartment_7660", "id": "reaction_10583222", "reactome": "R-DDI-112383", "name": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580699", "species_10583170", "species_10578883" ], "products": [ "species_10583215", "species_10580699" ], "modifiers": [ [ "species_10583170", "catalyst" ] ], "additional_components": [ "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "DDB_G0271690", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q75JA4", "DDB_G0271690", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "DDB_G0271690" ] }, "reaction_10583320": { "compartment": "compartment_7660", "id": "reaction_10583320", "reactome": "R-DDI-113412", "name": "Pol II elongation complex moves on the template as transcript elongates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583290", "species_30595" ], "products": [ "species_10583302", "species_30595" ], "modifiers": [], "additional_components": [ "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "species_110614", "species_113592", "species_29494", "species_29438", "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "species_110614", "species_113592", "species_29494", "species_29438" ] }, "reaction_10583306": { "compartment": "compartment_7660", "id": "reaction_10583306", "reactome": "R-DDI-112396", "name": "Separation of elongating transcript from template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583302" ], "products": [ "species_10583304" ], "modifiers": [], "additional_components": [ "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10583292": { "compartment": "compartment_7660", "id": "reaction_10583292", "reactome": "R-DDI-112385", "name": "Addition of nucleotides leads to transcript elongation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583288", "species_30595" ], "products": [ "species_10583290", "species_10580699" ], "modifiers": [], "additional_components": [ "Q86A81", "DDB_G0274327", "Q55F33", "DDB_G0268922", "Q75JA4", "DDB_G0271690", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q55A48", "DDB_G0272354", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "species_110614", "species_113592", "species_29494", "species_29438", "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729" ] }, "reaction_10583692": { "compartment": "compartment_7660", "id": "reaction_10583692", "reactome": "R-DDI-156682", "name": "PLK1 phosphorylates NUDC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10583686" ], "products": [ "species_10583690", "species_29370" ], "modifiers": [ [ "species_10583678", "catalyst" ] ], "additional_components": [ "DDB_G0286159", "DDB_G0286159", "DDB_G0274503" ] }, "reaction_10601043": { "compartment": "compartment_1598585", "id": "reaction_10601043", "reactome": "R-DDI-2466068", "name": "Phosphorylation of cohesin by PLK1 at chromosomal arms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10601028" ], "products": [ "species_29370", "species_10601040" ], "modifiers": [ [ "species_10585345", "catalyst" ] ], "additional_components": [ "Q550H7", "DDB_G0276977", "Q552D9", "DDB_G0276101", "Q54QR0", "DDB_G0283681", "Q54E85", "DDB_G0291752", "Q552Q7", "DDB_G0275929", "Q552Q7", "DDB_G0275929", "Q552D9", "DDB_G0276101", "Q54QR0", "DDB_G0283681", "Q550H7", "DDB_G0276977", "Q54E85", "DDB_G0291752", "DDB_G0274503" ] }, "reaction_10589619": { "compartment": "compartment_876", "id": "reaction_10589619", "reactome": "R-DDI-375405", "name": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_375409" ], "products": [ "species_70106", "species_375414" ], "modifiers": [ [ "species_10589616", "catalyst" ] ], "additional_components": [ "species_379717", "species_159549", "species_159549", "species_379717", "DDB_G0293074" ] }, "reaction_10589624": { "compartment": "compartment_876", "id": "reaction_10589624", "reactome": "R-DDI-375417", "name": "SLC36A1-mediated uptake of glycine, proline, and alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_375400" ], "products": [ "species_70106", "species_375411" ], "modifiers": [ [ "species_10589621", "catalyst" ] ], "additional_components": [ "species_389664", "species_379717", "species_159549", "species_159549", "species_379717", "species_389664", "DDB_G0293074" ] }, "reaction_10581901": { "compartment": "compartment_7660", "id": "reaction_10581901", "reactome": "R-DDI-76056", "name": "Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581835", "species_10581897" ], "products": [ "species_10581899" ], "modifiers": [], "additional_components": [ "Q8T1F9", "DDB_G0275127", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54YB5", "DDB_G0278321", "Q54FU1", "DDB_G0290591", "Q54U85", "DDB_G0281215", "Q54R53", "DDB_G0283405", "P26355", "DDB_G0275617", "Q557J3", "DDB_G0273425", "Q54LP2", "DDB_G0286521", "Q54R66", "DDB_G0283365", "Q54IM0", "DDB_G0288665", "Q55FJ5", "DDB_G0268080", "Q86JM3", "DDB_G0272022", "Q54EH2", "DDB_G0291636", "Q54K02", "DDB_G0287707", "Q54SN4", "DDB_G0282339", "Q54FA8", "DDB_G0291037", "Q8T1V7", "DDB_G0277671", "Q86JI9", "DDB_G0271514", "Q55AB6", "DDB_G0272036", "Q86AQ5", "DDB_G0277199", "Q54IZ9", "DDB_G0288449", "Q54YW8", "DDB_G0278039", "Q557J3", "DDB_G0273425", "Q54LP2", "DDB_G0286521", "Q54R66", "DDB_G0283365", "Q54IM0", "DDB_G0288665", "Q55FJ5", "DDB_G0268080", "Q86JM3", "DDB_G0272022", "Q54EH2", "DDB_G0291636", "Q54K02", "DDB_G0287707", "Q54SN4", "DDB_G0282339", "Q54FA8", "DDB_G0291037", "Q8T1V7", "DDB_G0277671", "Q86JI9", "DDB_G0271514", "Q55AB6", "DDB_G0272036", "Q86AQ5", "DDB_G0277199", "Q54IZ9", "DDB_G0288449", "Q54YW8", "DDB_G0278039", "Q8T1F9", "DDB_G0275127", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54YB5", "DDB_G0278321", "Q54FU1", "DDB_G0290591", "Q54U85", "DDB_G0281215", "Q54R53", "DDB_G0283405", "P26355", "DDB_G0275617" ] }, "reaction_10627075": { "compartment": "compartment_876", "id": "reaction_10627075", "reactome": "R-DDI-9657599", "name": "Dual mechanism MAP2K inhibitors bind MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657567", "species_10607239" ], "products": [ "species_10607241" ], "modifiers": [], "additional_components": [ "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54HS0", "DDB_G0289277", "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54HS0", "DDB_G0289277" ] }, "reaction_10607298": { "compartment": "compartment_74700", "id": "reaction_10607298", "reactome": "R-DDI-5674130", "name": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607294", "species_113592" ], "products": [ "species_29370", "species_10607296" ], "modifiers": [], "additional_components": [ "Q54H44", "DDB_G0289711", "Q54F59", "DDB_G0291091", "Q86J23", "DDB_G0274833", "Q54TM7", "DDB_G0281557", "Q54HS0", "DDB_G0289277", "Q54H44", "DDB_G0289711", "Q54F59", "DDB_G0291091", "Q86J23", "DDB_G0274833", "Q54TM7", "DDB_G0281557", "Q54HS0", "DDB_G0289277" ] }, "reaction_10607253": { "compartment": "compartment_876", "id": "reaction_10607253", "reactome": "R-DDI-5672978", "name": "RAF phosphorylates MAP2K dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607239" ], "products": [ "species_10607230", "species_29370" ], "modifiers": [ [ "species_10607239", "catalyst" ], [ "species_10607241", "inhibitor" ], [ "species_10607251", "inhibitor" ] ], "additional_components": [ "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54HS0", "DDB_G0289277", "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54HS0", "DDB_G0289277", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54HS0", "DDB_G0289277", "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54HS0", "DDB_G0289277", "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438" ] }, "reaction_10627079": { "compartment": "compartment_876", "id": "reaction_10627079", "reactome": "R-DDI-9657606", "name": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607230", "species_9657574" ], "products": [ "species_10607237" ], "modifiers": [], "additional_components": [ "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54HS0", "DDB_G0289277", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54HS0", "DDB_G0289277", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438" ] }, "reaction_10627077": { "compartment": "compartment_876", "id": "reaction_10627077", "reactome": "R-DDI-9657603", "name": "Dual mechanism MAPK inhibitors bind MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607230", "species_9657570" ], "products": [ "species_10607243" ], "modifiers": [], "additional_components": [ "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54HS0", "DDB_G0289277", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54HS0", "DDB_G0289277", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438" ] }, "reaction_10627083": { "compartment": "compartment_876", "id": "reaction_10627083", "reactome": "R-DDI-9657608", "name": "Single mechanism MAPK inhibitors bind phosphorylated MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657577", "species_10607234" ], "products": [ "species_10627081" ], "modifiers": [], "additional_components": [ "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54HS0", "DDB_G0289277", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54HS0", "DDB_G0289277", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438" ] }, "reaction_10607245": { "compartment": "compartment_876", "id": "reaction_10607245", "reactome": "R-DDI-5672973", "name": "MAP2Ks phosphorylate MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607230", "species_113592" ], "products": [ "species_29370", "species_10607234" ], "modifiers": [ [ "species_10607230", "catalyst" ], [ "species_10607237", "inhibitor" ], [ "species_10607241", "inhibitor" ], [ "species_10607243", "inhibitor" ] ], "additional_components": [ "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54HS0", "DDB_G0289277", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602093", "species_113560" ], "products": [ "species_2485002", "species_10602506" ], "modifiers": [ [ "species_10602530", "catalyst" ] ], "additional_components": [ "Q54QM3", "DDB_G0283859", "Q54NG3", "DDB_G0285275", "B0G130", "DDB_G0279699", "Q869X5", "DDB_G0279699", "Q54PN9", "DDB_G0284411" ] }, "reaction_10602468": { "compartment": "compartment_7660", "id": "reaction_10602468", "reactome": "R-DDI-3318413", "name": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600607", "species_113560" ], "products": [ "species_2485002", "species_10602427" ], "modifiers": [ [ "species_10602465", "catalyst" ] ], "additional_components": [ "DDB_G0291185", "DDB_G0291185", "B0G130", "DDB_G0279699", "Q869X5", "DDB_G0279699", "Q54NG3", "DDB_G0285275", "Q54PN9", "DDB_G0284411" ] }, "reaction_10602922": { "compartment": "compartment_7660", "id": "reaction_10602922", "reactome": "R-DDI-3662318", "name": "Type B histone acetlytransferase complex acetylates histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581418", "species_113560" ], "products": [ "species_2485002", "species_10602900" ], "modifiers": [ [ "species_10602919", "catalyst" ] ], "additional_components": [ "DDB_G0276863", "DDB_G0276863", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q86J12", "DDB_G0274269" ] }, "reaction_10606579": { "compartment": "compartment_7660", "id": "reaction_10606579", "reactome": "R-DDI-5661121", "name": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606223", "species_113671", "species_113685" ], "products": [ "species_10604220", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10604227", "catalyst" ] ], "additional_components": [ "DDB_G0269194" ] }, "reaction_10604197": { "compartment": "compartment_7660", "id": "reaction_10604197", "reactome": "R-DDI-4754176", "name": "JMJD6 demethylates MeR3-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602206", "species_113671", "species_113685" ], "products": [ "species_10602093", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10604194", "catalyst" ] ], "additional_components": [ "DDB_G0279409" ] }, "reaction_10606581": { "compartment": "compartment_7660", "id": "reaction_10606581", "reactome": "R-DDI-5661122", "name": "JMJD6 demethylates Me2R3-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604669", "species_113671", "species_113685" ], "products": [ "species_10602206", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10604194", "catalyst" ] ], "additional_components": [ "DDB_G0279409" ] }, "reaction_10604215": { "compartment": "compartment_7660", "id": "reaction_10604215", "reactome": "R-DDI-4754181", "name": "KDM5A-D demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10604199", "species_113685" ], "products": [ "species_10602091", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10604212", "catalyst" ] ], "additional_components": [ "Q55ER4", "DDB_G0268778" ] }, "reaction_10606583": { "compartment": "compartment_7660", "id": "reaction_10606583", "reactome": "R-DDI-5661124", "name": "JMJD6 demethylates MeR4-HIST1H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604614", "species_113671", "species_113685" ], "products": [ "species_10581418", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10604194", "catalyst" ] ], "additional_components": [ "DDB_G0276863", "DDB_G0276863", "DDB_G0279409" ] }, "reaction_10606585": { "compartment": "compartment_7660", "id": "reaction_10606585", "reactome": "R-DDI-5661125", "name": "JMJD6 demethylates Me2sR4-HIST1H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604678", "species_113671", "species_113685" ], "products": [ "species_10604614", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10604194", "catalyst" ] ], "additional_components": [ "DDB_G0276863", "DDB_G0276863", "DDB_G0279409" ] }, "reaction_10604232": { "compartment": "compartment_7660", "id": "reaction_10604232", "reactome": "R-DDI-4754187", "name": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604220", "species_113671", "species_113685" ], "products": [ "species_29478", "species_159942", "species_159939", "species_10604225" ], "modifiers": [ [ "species_10604227", "catalyst" ] ], "additional_components": [ "DDB_G0269194" ] }, "reaction_10606572": { "compartment": "compartment_7660", "id": "reaction_10606572", "reactome": "R-DDI-5661116", "name": "KDM5A-D demethylate Me3K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604902", "species_113671", "species_113685" ], "products": [ "species_29478", "species_10604199", "species_159942", "species_159939" ], "modifiers": [ [ "species_10604212", "catalyst" ] ], "additional_components": [ "Q55ER4", "DDB_G0268778" ] }, "reaction_10627346": { "compartment": "compartment_7660", "id": "reaction_10627346", "reactome": "R-DDI-9679787", "name": "HDAC1:2-containing complex binds HDAC2 Inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603176", "species_9679795" ], "products": [ "species_10603179" ], "modifiers": [], "additional_components": [ "Q54PU3", "DDB_G0284289", "Q54LI3", "DDB_G0286805", "Q54QG3", "DDB_G0283845", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q55FN5", "DDB_G0268024", "Q54NX4", "DDB_G0285057", "Q54PU3", "DDB_G0284289", "Q54LI3", "DDB_G0286805", "Q54QG3", "DDB_G0283845", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q55FN5", "DDB_G0268024", "Q54NX4", "DDB_G0285057" ] }, "reaction_10603206": { "compartment": "compartment_7660", "id": "reaction_10603206", "reactome": "R-DDI-3782655", "name": "HDAC10 deacetylates histone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10603132" ], "products": [ "species_10603138", "species_5566518" ], "modifiers": [ [ "species_10603203", "catalyst" ] ], "additional_components": [ "Q76NW2", "DDB_G0276863", "Q54X15", "DDB_G0279267", "Q54VQ7", "DDB_G0280195" ] }, "reaction_10603181": { "compartment": "compartment_7660", "id": "reaction_10603181", "reactome": "R-DDI-3769447", "name": "HDAC1:2-containing complex deacetylate histones", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10603132" ], "products": [ "species_10603138", "species_5566518" ], "modifiers": [ [ "species_10603176", "catalyst" ], [ "species_10603179", "inhibitor" ] ], "additional_components": [ "Q76NW2", "DDB_G0276863", "Q54PU3", "DDB_G0284289", "Q54LI3", "DDB_G0286805", "Q54QG3", "DDB_G0283845", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q55FN5", "DDB_G0268024", "Q54NX4", "DDB_G0285057", "Q54PU3", "DDB_G0284289", "Q54LI3", "DDB_G0286805", "Q54QG3", "DDB_G0283845", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q55FN5", "DDB_G0268024", "Q54NX4", "DDB_G0285057" ] }, "reaction_10604673": { "compartment": "compartment_7660", "id": "reaction_10604673", "reactome": "R-DDI-5205824", "name": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10604664" ], "products": [ "species_77502", "species_10604671" ], "modifiers": [ [ "species_10604619", "catalyst" ] ], "additional_components": [ "DDB_G0289445" ] }, "reaction_10604624": { "compartment": "compartment_7660", "id": "reaction_10604624", "reactome": "R-DDI-5205798", "name": "PRMT1,PRMT6 methylate arginine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10581418" ], "products": [ "species_77502", "species_10604614" ], "modifiers": [ [ "species_10604621", "catalyst" ] ], "additional_components": [ "DDB_G0276863", "DDB_G0276863", "Q54EF2", "DDB_G0291556", "Q54HI0", "DDB_G0289445" ] }, "reaction_10604709": { "compartment": "compartment_7660", "id": "reaction_10604709", "reactome": "R-DDI-5205867", "name": "PRMT1 methylates arginine-12 of histone H2A (H2AR11)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10604693" ], "products": [ "species_77502", "species_10604706" ], "modifiers": [ [ "species_10602098", "catalyst" ] ], "additional_components": [ "DDB_G0291556" ] }, "reaction_10604900": { "compartment": "compartment_7660", "id": "reaction_10604900", "reactome": "R-DDI-5229203", "name": "PRMT6 methylates histone H2A arginine-30 (H2AR29)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10604885" ], "products": [ "species_77502", "species_10604898" ], "modifiers": [ [ "species_10604619", "catalyst" ] ], "additional_components": [ "DDB_G0289445" ] }, "reaction_10604791": { "compartment": "compartment_7660", "id": "reaction_10604791", "reactome": "R-DDI-5225602", "name": "WDR5 binds Me2sR3-replicative histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604420", "species_10604769" ], "products": [ "species_10604789" ], "modifiers": [], "additional_components": [ "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127" ] }, "reaction_10604795": { "compartment": "compartment_7660", "id": "reaction_10604795", "reactome": "R-DDI-5225649", "name": "RBBP7 binds histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602093", "species_10602917" ], "products": [ "species_10604793" ], "modifiers": [ [ "species_10604769", "inhibitor" ] ], "additional_components": [ "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565" ] }, "reaction_10604653": { "compartment": "compartment_7660", "id": "reaction_10604653", "reactome": "R-DDI-5205820", "name": "PRMT6 methylates arginine-4 of histone H2A (H2AR3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10604637" ], "products": [ "species_77502", "species_10604650" ], "modifiers": [ [ "species_10604619", "catalyst" ] ], "additional_components": [ "DDB_G0289445" ] }, "reaction_10606590": { "compartment": "compartment_7660", "id": "reaction_10606590", "reactome": "R-DDI-5661126", "name": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10604614" ], "products": [ "species_77502", "species_10606588" ], "modifiers": [ [ "species_10604621", "catalyst" ] ], "additional_components": [ "DDB_G0276863", "DDB_G0276863", "Q54EF2", "DDB_G0291556", "Q54HI0", "DDB_G0289445" ] }, "reaction_10606145": { "compartment": "compartment_7660", "id": "reaction_10606145", "reactome": "R-DDI-5637686", "name": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10602091" ], "products": [ "species_77502", "species_10604199" ], "modifiers": [ [ "species_10606142", "catalyst" ] ], "additional_components": [ "Q54HS3", "DDB_G0289257", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q54MH6", "DDB_G0285847", "Q55AQ4", "DDB_G0271754", "Q54IV4", "DDB_G0288495", "Q55D68", "DDB_G0269768" ] }, "reaction_10604245": { "compartment": "compartment_7660", "id": "reaction_10604245", "reactome": "R-DDI-4827382", "name": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10604187" ], "products": [ "species_77502", "species_10604237" ], "modifiers": [ [ "species_10604242", "catalyst" ] ], "additional_components": [ "DDB_G0289257" ] }, "reaction_10606212": { "compartment": "compartment_7660", "id": "reaction_10606212", "reactome": "R-DDI-5649764", "name": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10606199" ], "products": [ "species_77502", "species_10606204" ], "modifiers": [ [ "species_10606209", "catalyst" ] ], "additional_components": [ "DDB_G0271626" ] }, "reaction_10604439": { "compartment": "compartment_7660", "id": "reaction_10604439", "reactome": "R-DDI-5159245", "name": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10602093" ], "products": [ "species_77502", "species_10602091" ], "modifiers": [ [ "species_10604436", "catalyst" ] ], "additional_components": [ "Q54J80", "DDB_G0288227", "Q54HS3", "DDB_G0289257", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q54MH6", "DDB_G0285847", "Q55AQ4", "DDB_G0271754", "Q55D68", "DDB_G0269768" ] }, "reaction_10606166": { "compartment": "compartment_7660", "id": "reaction_10606166", "reactome": "R-DDI-5638157", "name": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10604185" ], "products": [ "species_77502", "species_10606159" ], "modifiers": [ [ "species_10604312", "catalyst" ] ], "additional_components": [ "Q54ZX8", "DDB_G0294629", "Q54D67", "DDB_G0294629", "Q557F6", "DDB_G0294629", "Q54DL6", "DDB_G0294629", "Q557F7", "DDB_G0294629", "Q54GG3", "DDB_G0294629", "Q55DC8", "DDB_G0270830", "Q54IV4", "DDB_G0288495", "Q55FX4", "DDB_G0294629", "Q54R14", "DDB_G0294629", "B0G196", "DDB_G0294629", "Q54XN6", "DDB_G0294629", "C7G064", "DDB_G0294629" ] }, "reaction_10604315": { "compartment": "compartment_7660", "id": "reaction_10604315", "reactome": "R-DDI-4827383", "name": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10602093" ], "products": [ "species_77502", "species_10604185" ], "modifiers": [ [ "species_10604312", "catalyst" ] ], "additional_components": [ "Q54ZX8", "DDB_G0294629", "Q54D67", "DDB_G0294629", "Q557F6", "DDB_G0294629", "Q54DL6", "DDB_G0294629", "Q557F7", "DDB_G0294629", "Q54GG3", "DDB_G0294629", "Q55DC8", "DDB_G0270830", "Q54IV4", "DDB_G0288495", "Q55FX4", "DDB_G0294629", "Q54R14", "DDB_G0294629", "B0G196", "DDB_G0294629", "Q54XN6", "DDB_G0294629", "C7G064", "DDB_G0294629" ] }, "reaction_10606219": { "compartment": "compartment_7660", "id": "reaction_10606219", "reactome": "R-DDI-5649799", "name": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10606204" ], "products": [ "species_77502", "species_10606217" ], "modifiers": [ [ "species_10606209", "catalyst" ] ], "additional_components": [ "DDB_G0271626" ] }, "reaction_10604909": { "compartment": "compartment_7660", "id": "reaction_10604909", "reactome": "R-DDI-5244692", "name": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10604199" ], "products": [ "species_77502", "species_10604902" ], "modifiers": [ [ "species_10604906", "catalyst" ], [ "species_10604671", "inhibitor" ] ], "additional_components": [ "Q54HS3", "DDB_G0289257", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q54MH6", "DDB_G0285847", "Q55AQ4", "DDB_G0271754", "Q54IV4", "DDB_G0288495" ] }, "reaction_10606221": { "compartment": "compartment_7660", "id": "reaction_10606221", "reactome": "R-DDI-5649801", "name": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10602093" ], "products": [ "species_77502", "species_10606199" ], "modifiers": [ [ "species_10606209", "catalyst" ] ], "additional_components": [ "DDB_G0271626" ] }, "reaction_10589176": { "compartment": "compartment_876", "id": "reaction_10589176", "reactome": "R-DDI-266082", "name": "ABCG1-mediated transport of intracellular cholesterol to the cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_216762", "species_113592" ], "products": [ "species_29372", "species_29370", "species_171095" ], "modifiers": [ [ "species_10589173", "catalyst" ] ], "additional_components": [ "Q8T689", "DDB_G0289657", "Q54T02", "DDB_G0282103", "Q55DA0", "DDB_G0270826", "Q55DW4", "DDB_G0269214", "Q86HQ2", "DDB_G0274117", "Q8T685", "DDB_G0274115", "Q8T686", "DDB_G0289655" ] }, "reaction_10604343": { "compartment": "compartment_7660", "id": "reaction_10604343", "reactome": "R-DDI-5082356", "name": "HSF1-mediated gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604325" ], "products": [ "species_10604331" ], "modifiers": [ [ "species_10604336", "catalyst" ], [ "species_10604341", "catalyst" ] ], "additional_components": [ "Q54UC1", "DDB_G0281165", "P54651", "DDB_G0267400", "P36415", "DDB_G0269144", "Q556J3", "DDB_G0272620", "Q54UC1", "DDB_G0281165", "Q54UC1", "DDB_G0281165" ] }, "reaction_10604364": { "compartment": "compartment_7660", "id": "reaction_10604364", "reactome": "R-DDI-5082405", "name": "Phosphorylation of HSF1 at Ser326 induces transactivation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10602818" ], "products": [ "species_113582", "species_10604341" ], "modifiers": [ [ "species_10604361", "catalyst" ] ], "additional_components": [ "Q54UC1", "DDB_G0281165", "Q54UC1", "DDB_G0281165", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54D08", "DDB_G0292592" ] }, "reaction_10590646": { "compartment": "compartment_70101", "id": "reaction_10590646", "reactome": "R-DDI-392834", "name": "Activation of EPACs by cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10590642" ], "products": [ "species_10590644" ], "modifiers": [], "additional_components": [ "Q54TK8", "DDB_G0281573", "Q8IS12", "DDB_G0275703", "Q54TK8", "DDB_G0281573", "Q8IS12", "DDB_G0275703", "species_30389" ] }, "reaction_10594377": { "compartment": "compartment_70101", "id": "reaction_10594377", "reactome": "R-DDI-913996", "name": "PKA/PKG phosphorylate Rap1GAP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10590629" ], "products": [ "species_10594364", "species_29370" ], "modifiers": [ [ "species_10594374", "catalyst" ] ], "additional_components": [ "Q54Q75", "DDB_G0284065", "Q54SS8", "DDB_G0282247", "Q54Q75", "DDB_G0284065", "Q54SS8", "DDB_G0282247", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029", "P34099", "DDB_G0283907" ] }, "reaction_10590634": { "compartment": "compartment_70101", "id": "reaction_10590634", "reactome": "R-DDI-392513", "name": "Rap1 signal termination by Rap1GAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589457" ], "products": [ "species_111294", "species_10589459" ], "modifiers": [ [ "species_10590631", "catalyst" ] ], "additional_components": [ "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "species_29438", "species_29420", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "Q54Q75", "DDB_G0284065", "Q54SS8", "DDB_G0282247" ] }, "reaction_10590655": { "compartment": "compartment_70101", "id": "reaction_10590655", "reactome": "R-DDI-392835", "name": "Rap1 sequesters Raf1 to inhibit ERK cascade", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590651", "species_10589457" ], "products": [ "species_10590653" ], "modifiers": [], "additional_components": [ "DDB_G0281557", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "species_29438", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "species_29438", "Q54TM7", "DDB_G0281557" ] }, "reaction_10582742": { "compartment": "compartment_7660", "id": "reaction_10582742", "reactome": "R-DDI-110243", "name": "Excision of 8-oxoguanine by OGG1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582737" ], "products": [ "species_110242", "species_10582739" ], "modifiers": [ [ "species_10582737", "catalyst" ] ], "additional_components": [ "Q54CZ3", "DDB_G0292618", "Q54CZ3", "DDB_G0292618", "Q54CZ3", "DDB_G0292618" ] }, "reaction_10582763": { "compartment": "compartment_7660", "id": "reaction_10582763", "reactome": "R-DDI-110246", "name": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582758" ], "products": [ "species_5635947", "species_10582760" ], "modifiers": [ [ "species_10582758", "catalyst" ] ], "additional_components": [ "Q1ZXP7", "DDB_G0270764", "Q1ZXP7", "DDB_G0270764", "Q1ZXP7", "DDB_G0270764" ] }, "reaction_10592618": { "compartment": "compartment_70101", "id": "reaction_10592618", "reactome": "R-DDI-445072", "name": "Interaction of PAK1 with Rac1-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590366", "species_10583374", "species_113592" ], "products": [ "species_10590364", "species_29370", "species_10592615" ], "modifiers": [ [ "species_10590364", "catalyst" ] ], "additional_components": [ "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "P34144", "DDB_G0277869", "species_29438", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "Q869N2", "DDB_G0276459", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "P34144", "DDB_G0277869", "species_29438", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459" ] }, "reaction_10612893": { "compartment": "compartment_984", "id": "reaction_10612893", "reactome": "R-DDI-6789310", "name": "LIPs hydrolyse TG to DAG and RCOOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174675", "species_6789319" ], "modifiers": [ [ "species_10612890", "catalyst" ] ], "additional_components": [ "Q55EU1", "DDB_G0268966", "Q55EU8", "DDB_G0268966", "Q55EU9", "DDB_G0268966" ] }, "reaction_10594235": { "compartment": "compartment_876", "id": "reaction_10594235", "reactome": "R-DDI-879411", "name": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594231", "species_10594227" ], "products": [ "species_10594233" ], "modifiers": [], "additional_components": [ "Q55C24", "DDB_G0270260", "species_1236719", "CHEBI:60125", "CHEBI:53014", "DDB_G0287833", "Q54JR7", "DDB_G0287833", "Q55C24", "DDB_G0270260", "species_1236719", "CHEBI:60125", "CHEBI:53014" ] }, "reaction_10617470": { "compartment": "compartment_7660", "id": "reaction_10617470", "reactome": "R-DDI-6810233", "name": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10617458" ], "products": [ "species_113582", "species_10617467" ], "modifiers": [ [ "species_10617458", "catalyst" ] ], "additional_components": [ "Q54B89", "DDB_G0293830", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54XM9", "DDB_G0278843", "Q54CN8", "DDB_G0292838", "Q54IW7", "DDB_G0288471", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "P54685", "DDB_G0285417", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "P26355", "DDB_G0275617", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54FD6", "DDB_G0290929", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54XM9", "DDB_G0278843", "Q54CN8", "DDB_G0292838", "Q54IW7", "DDB_G0288471", "Q54B89", "DDB_G0293830", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "P54685", "DDB_G0285417", "P26355", "DDB_G0275617", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54FD6", "DDB_G0290929", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54B89", "DDB_G0293830", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54XM9", "DDB_G0278843", "Q54CN8", "DDB_G0292838", "Q54IW7", "DDB_G0288471", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "P54685", "DDB_G0285417", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "P26355", "DDB_G0275617", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54FD6", "DDB_G0290929" ] }, "reaction_10627486": { "compartment": "compartment_70101", "id": "reaction_10627486", "reactome": "R-DDI-9712274", "name": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622861", "species_9714134" ], "products": [ "species_10627484" ], "modifiers": [], "additional_components": [ "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903", "Q55BF8", "DDB_G0271372", "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903", "Q55BF8", "DDB_G0271372" ] }, "reaction_10591159": { "compartment": "compartment_20699", "id": "reaction_10591159", "reactome": "R-DDI-421831", "name": "trans-Golgi Network Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10591135", "species_10591129", "species_10591141", "species_10591123" ], "products": [ "species_10589294", "species_29372", "species_10591157" ], "modifiers": [], "additional_components": [ "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "O00909", "DDB_G0289173", "Q54Y34", "DDB_G0292332", "Q1ZXA5", "DDB_G0292332", "Q54YV7", "DDB_G0278057", "Q54HK2", "DDB_G0289435", "Q55AR1", "DDB_G0271792", "Q54JJ3", "DDB_G0288015", "Q54SH9", "DDB_G0282457", "Q54V41", "DDB_G0280633", "Q54V47", "DDB_G0280621", "Q54VB0", "DDB_G0280479", "species_29438", "Q54HS9", "DDB_G0289247", "Q54WW3", "DDB_G0279359", "B0G185", "DDB_G0295711", "Q8I8U2", "DDB_G0281957", "Q54X82", "DDB_G0279141", "species_29420", "Q54V41", "DDB_G0280633", "Q54Y34", "DDB_G0292332", "Q54HK2", "DDB_G0289435", "Q54YV7", "DDB_G0278057", "Q54JJ3", "DDB_G0288015", "Q54V47", "DDB_G0280621", "O00909", "DDB_G0289173", "Q54VB0", "DDB_G0280479", "Q55AR1", "DDB_G0271792", "Q1ZXA5", "DDB_G0292332", "Q54SH9", "DDB_G0282457", "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q54HS9", "DDB_G0289247", "Q54WW3", "DDB_G0279359", "B0G185", "DDB_G0295711", "Q8I8U2", "DDB_G0281957", "Q54X82", "DDB_G0279141" ] }, "reaction_10591320": { "compartment": "compartment_70101", "id": "reaction_10591320", "reactome": "R-DDI-421835", "name": "trans-Golgi Network Vesicle Scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10591157" ], "products": [ "species_10591135", "species_29372", "species_29420", "species_10591141", "species_10591317" ], "modifiers": [ [ "species_10591157", "catalyst" ] ], "additional_components": [ "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q54HS9", "DDB_G0289247", "Q54WW3", "DDB_G0279359", "B0G185", "DDB_G0295711", "Q8I8U2", "DDB_G0281957", "Q54X82", "DDB_G0279141", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q8I8U2", "DDB_G0281957", "Q54HS9", "DDB_G0289247", "B0G185", "DDB_G0295711", "Q54WW3", "DDB_G0279359", "Q54X82", "DDB_G0279141", "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q54HS9", "DDB_G0289247", "Q54WW3", "DDB_G0279359", "B0G185", "DDB_G0295711", "Q8I8U2", "DDB_G0281957", "Q54X82", "DDB_G0279141" ] }, "reaction_10589780": { "compartment": "compartment_70101", "id": "reaction_10589780", "reactome": "R-DDI-379382", "name": "MAOA:FAD deaminates DA to DOPAC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29368", "species_159362" ], "products": [ "species_9677997", "species_29382", "species_29408" ], "modifiers": [ [ "species_10583604", "catalyst" ] ], "additional_components": [ "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10589782": { "compartment": "compartment_70101", "id": "reaction_10589782", "reactome": "R-DDI-379395", "name": "MAOA:FAD deaminates 3MT to HVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8954997", "species_29356", "species_29368" ], "products": [ "species_9677992", "species_29382", "species_29408" ], "modifiers": [ [ "species_10583604", "catalyst" ] ], "additional_components": [ "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10604787": { "compartment": "compartment_70101", "id": "reaction_10604787", "reactome": "R-DDI-5223317", "name": "ABCB9 transports peptides from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5223341" ], "products": [ "species_5223344", "species_29372", "species_29370" ], "modifiers": [ [ "species_10604784", "catalyst" ] ], "additional_components": [ "Q54BU4", "DDB_G0293416" ] }, "reaction_10597683": { "compartment": "compartment_17906", "id": "reaction_10597683", "reactome": "R-DDI-1369065", "name": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1369066", "species_29356", "species_113592" ], "products": [ "species_29372", "species_29370", "species_1369027" ], "modifiers": [ [ "species_10597680", "catalyst" ] ], "additional_components": [ "Q8T9W2", "DDB_G0292554" ] }, "reaction_10590190": { "compartment": "compartment_70616", "id": "reaction_10590190", "reactome": "R-DDI-382560", "name": "ABC7, mABC1 and mABC2 mediate heme transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_189444", "species_113521" ], "products": [ "species_113548", "species_113581", "species_71185" ], "modifiers": [ [ "species_10590187", "catalyst" ] ], "additional_components": [ "Q8T9W2", "DDB_G0292554" ] }, "reaction_10619974": { "compartment": "compartment_876", "id": "reaction_10619974", "reactome": "R-DDI-8866851", "name": "CFTR transits to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619958" ], "products": [ "species_10590243" ], "modifiers": [], "additional_components": [ "Q54U44", "DDB_G0280973", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q54LE6", "DDB_G0286559", "Q54P13", "DDB_G0284867", "Q54U44", "DDB_G0280973" ] }, "reaction_10618468": { "compartment": "compartment_70101", "id": "reaction_10618468", "reactome": "R-DDI-8848053", "name": "ABCA5 transports CHOL from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_8848047" ], "products": [ "species_29372", "species_176478", "species_29370" ], "modifiers": [ [ "species_10618465", "catalyst" ] ], "additional_components": [ "Q54BT5", "DDB_G0293436", "Q55BC0", "DDB_G0271138", "Q555Z5", "DDB_G0274121", "Q8T6J1", "DDB_G0291245", "Q8T5Z7", "DDB_G0291994", "Q8T6J5", "DDB_G0267438", "Q8T6J2", "DDB_G0274119" ] }, "reaction_10590231": { "compartment": "compartment_17947", "id": "reaction_10590231", "reactome": "R-DDI-382613", "name": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590229", "species_10590211" ], "products": [ "species_10590203", "species_10590227", "species_10590211" ], "modifiers": [], "additional_components": [ "Q555I0", "DDB_G0274873", "Q8T8P3", "DDB_G0293194", "DDB_G0281213", "Q8T8P3", "DDB_G0293194", "DDB_G0274873", "DDB_G0281213" ] }, "reaction_10589110": { "compartment": "compartment_876", "id": "reaction_10589110", "reactome": "R-DDI-265783", "name": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_265784", "species_113592" ], "products": [ "species_29372", "species_29370", "species_265781" ], "modifiers": [ [ "species_10589107", "catalyst" ] ], "additional_components": [ "CHEBI:26125", "species_216762", "CHEBI:26125", "species_216762", "Q54T02", "DDB_G0282103", "Q86HQ2", "DDB_G0274117", "Q8T685", "DDB_G0274115", "Q55DA0", "DDB_G0270826", "Q55DW4", "DDB_G0269214", "Q8T686", "DDB_G0289655", "Q8T689", "DDB_G0289657" ] }, "reaction_10597819": { "compartment": "compartment_70101", "id": "reaction_10597819", "reactome": "R-DDI-1454928", "name": "ABCG4 may mediate cholesterol efflux", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176478", "species_29356", "species_113592" ], "products": [ "species_171149", "species_29372", "species_29370" ], "modifiers": [ [ "species_10597816", "catalyst" ] ], "additional_components": [ "Q8T685", "DDB_G0274115", "Q8T686", "DDB_G0289655", "Q8T689", "DDB_G0289657", "Q54T02", "DDB_G0282103", "Q55DA0", "DDB_G0270826", "Q55DW4", "DDB_G0269214", "Q86HQ2", "DDB_G0274117" ] }, "reaction_10597674": { "compartment": "compartment_876", "id": "reaction_10597674", "reactome": "R-DDI-1369028", "name": "ABCAs mediate lipid efflux", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_176478", "species_113592" ], "products": [ "species_171149", "species_29372", "species_29370" ], "modifiers": [ [ "species_10597671", "catalyst" ] ], "additional_components": [] }, "reaction_10597676": { "compartment": "compartment_876", "id": "reaction_10597676", "reactome": "R-DDI-1369052", "name": "ABCAs mediate lipid influx", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_171149", "species_29356", "species_113592" ], "products": [ "species_29372", "species_176478", "species_29370" ], "modifiers": [ [ "species_10597671", "catalyst" ] ], "additional_components": [] }, "reaction_10607964": { "compartment": "compartment_70101", "id": "reaction_10607964", "reactome": "R-DDI-5682285", "name": "ABCA12 transports lipids from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5682283", "species_29356", "species_113592" ], "products": [ "species_29372", "species_29370", "species_5229279" ], "modifiers": [ [ "species_10607961", "catalyst" ] ], "additional_components": [ "Q8T5Z7", "DDB_G0291994", "Q8T6J1", "DDB_G0291245", "Q8T6J2", "DDB_G0274119", "Q8T6J5", "DDB_G0267438", "Q54BT5", "DDB_G0293436", "Q555Z5", "DDB_G0274121", "Q55BC0", "DDB_G0271138" ] }, "reaction_10590206": { "compartment": "compartment_17947", "id": "reaction_10590206", "reactome": "R-DDI-382575", "name": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_382577" ], "products": [ "species_382571", "species_29372", "species_29370" ], "modifiers": [ [ "species_10590203", "catalyst" ] ], "additional_components": [ "Q8T8P3", "DDB_G0293194" ] }, "reaction_10590246": { "compartment": "compartment_876", "id": "reaction_10590246", "reactome": "R-DDI-383190", "name": "HCO3- transport through ion channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111627", "species_113592" ], "products": [ "species_29372", "species_29370", "species_425425" ], "modifiers": [ [ "species_10590243", "catalyst" ] ], "additional_components": [ "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q54LE6", "DDB_G0286559", "Q54P13", "DDB_G0284867", "Q54U44", "DDB_G0280973" ] }, "reaction_10597798": { "compartment": "compartment_70101", "id": "reaction_10597798", "reactome": "R-DDI-1454916", "name": "The ABCC family mediates organic anion transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_1454930" ], "products": [ "species_29372", "species_29370", "species_1454919" ], "modifiers": [ [ "species_10597795", "catalyst" ] ], "additional_components": [ "Q54EK2", "DDB_G0291243", "Q54K24", "DDB_G0287589", "Q54NL1", "DDB_G0285165", "Q54V86", "DDB_G0280539", "Q54VC1", "DDB_G0280459", "Q54VJ0", "DDB_G0280055", "Q8T6H3", "DDB_G0287593", "Q8T6H8", "DDB_G0280541", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q54LE6", "DDB_G0286559", "Q54P13", "DDB_G0284867", "Q54U44", "DDB_G0280973" ] }, "reaction_10619962": { "compartment": "compartment_70101", "id": "reaction_10619962", "reactome": "R-DDI-8866553", "name": "misfolded CFTR is degraded by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619960" ], "products": [ "species_10577037" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q54U44", "DDB_G0280973", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10597848": { "compartment": "compartment_876", "id": "reaction_10597848", "reactome": "R-DDI-1467457", "name": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_1131652" ], "products": [ "species_29372", "species_29370", "species_1467459" ], "modifiers": [ [ "species_10597845", "catalyst" ] ], "additional_components": [ "Q8T9W4", "DDB_G0291714", "Q54BT3", "DDB_G0293438", "Q55BC0", "DDB_G0271138", "Q8T5Z7", "DDB_G0291994", "Q8T6J1", "DDB_G0291245", "Q8T6J2", "DDB_G0274119", "Q8T6J5", "DDB_G0267438", "Q54BT5", "DDB_G0293436", "Q555Z5", "DDB_G0274121" ] }, "reaction_10607707": { "compartment": "compartment_984", "id": "reaction_10607707", "reactome": "R-DDI-5678706", "name": "ABCB4 transports PC from plasma membrane to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429802", "species_113592" ], "products": [ "species_382539", "species_29372", "species_29370" ], "modifiers": [ [ "species_10607704", "catalyst" ] ], "additional_components": [ "Q54BT3", "DDB_G0293438", "Q8T9W4", "DDB_G0291714" ] }, "reaction_10597867": { "compartment": "compartment_74000", "id": "reaction_10597867", "reactome": "R-DDI-1467466", "name": "ABCA4 mediates atRAL transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_2466098" ], "products": [ "species_29372", "species_29370", "species_975622" ], "modifiers": [ [ "species_10597864", "catalyst" ] ], "additional_components": [ "Q8T5Z7", "DDB_G0291994", "Q8T6J1", "DDB_G0291245", "Q8T6J2", "DDB_G0274119", "Q8T6J5", "DDB_G0267438", "Q54BT5", "DDB_G0293436", "Q555Z5", "DDB_G0274121", "Q55BC0", "DDB_G0271138" ] }, "reaction_10604826": { "compartment": "compartment_70101", "id": "reaction_10604826", "reactome": "R-DDI-5227009", "name": "ABCF1 binds EIF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604822", "species_10580002" ], "products": [ "species_10604824" ], "modifiers": [], "additional_components": [ "DDB_G0267436", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "Q8T6B4", "DDB_G0267436" ] }, "reaction_10607710": { "compartment": "compartment_70101", "id": "reaction_10607710", "reactome": "R-DDI-5678863", "name": "CFTR transports Cl- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_352022" ], "products": [ "species_188972", "species_29372", "species_29370" ], "modifiers": [ [ "species_10590243", "catalyst" ] ], "additional_components": [ "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q54LE6", "DDB_G0286559", "Q54P13", "DDB_G0284867", "Q54U44", "DDB_G0280973" ] }, "reaction_10584149": { "compartment": "compartment_70101", "id": "reaction_10584149", "reactome": "R-DDI-165162", "name": "Phosphorylation of TSC2 by PKB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584141", "species_113592" ], "products": [ "species_29370", "species_10584146" ], "modifiers": [ [ "species_10582598", "catalyst" ] ], "additional_components": [ "DDB_G0280527", "DDB_G0280527", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_179838" ] }, "reaction_10624166": { "compartment": "compartment_876", "id": "reaction_10624166", "reactome": "R-DDI-8981353", "name": "RASA1 stimulates RAS GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624163" ], "products": [ "species_10585895", "species_10585874" ], "modifiers": [ [ "species_10624163", "catalyst" ] ], "additional_components": [ "Q54Q13", "DDB_G0284177", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "DDB_G0284177", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29420", "Q54Q13", "DDB_G0284177", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438" ] }, "reaction_10624168": { "compartment": "compartment_876", "id": "reaction_10624168", "reactome": "R-DDI-8981355", "name": "RASA1 binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585144", "species_10585895" ], "products": [ "species_10624163" ], "modifiers": [], "additional_components": [ "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "DDB_G0284177", "Q54Q13", "DDB_G0284177", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438" ] }, "reaction_10617858": { "compartment": "compartment_263163", "id": "reaction_10617858", "reactome": "R-DDI-6814088", "name": "SYS1 binds AcM-ARFRP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617856", "species_10617826" ], "products": [ "species_10617836" ], "modifiers": [], "additional_components": [ "Q54QU7", "DDB_G0283631", "species_29438", "DDB_G0269368", "Q55E69", "DDB_G0269368", "Q54QU7", "DDB_G0283631", "species_29438" ] }, "reaction_10617680": { "compartment": "compartment_263163", "id": "reaction_10617680", "reactome": "R-DDI-6811428", "name": "RIC1:RGP1 recruits RAB6:GDP to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617658", "species_10617670" ], "products": [ "species_10617678" ], "modifiers": [], "additional_components": [ "Q55FK2", "DDB_G0268068", "species_29420", "Q54WR7", "DDB_G0279477", "Q76NU4", "DDB_G0277397", "Q54WR7", "DDB_G0279477", "Q76NU4", "DDB_G0277397", "Q55FK2", "DDB_G0268068", "species_29420" ] }, "reaction_10618272": { "compartment": "compartment_263163", "id": "reaction_10618272", "reactome": "R-DDI-6814678", "name": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618267", "species_113592" ], "products": [ "species_10611694", "species_10618041", "species_10617977", "species_29370", "species_10611703", "species_10617975", "species_10617985" ], "modifiers": [ [ "species_10618267", "catalyst" ] ], "additional_components": [ "Q54CK6", "DDB_G0292974", "Q553C3", "DDB_G0275765", "Q54R67", "DDB_G0283363", "Q54I20", "DDB_G0289063", "Q551H5", "DDB_G0276575", "Q54GB3", "DDB_G0290363", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153", "Q75JI3", "DDB_G0276153", "DDB_G0290363", "DDB_G0276575", "Q54NP6", "DDB_G0285111", "DDB_G0289063", "Q54CK6", "DDB_G0292974", "Q553C3", "DDB_G0275765", "Q54R67", "DDB_G0283363", "Q54CK6", "DDB_G0292974", "Q553C3", "DDB_G0275765", "Q54R67", "DDB_G0283363", "Q54I20", "DDB_G0289063", "Q551H5", "DDB_G0276575", "Q54GB3", "DDB_G0290363", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153" ] }, "reaction_10617687": { "compartment": "compartment_263163", "id": "reaction_10617687", "reactome": "R-DDI-6811429", "name": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10617678" ], "products": [ "species_29420", "species_10617684" ], "modifiers": [ [ "species_10617678", "catalyst" ] ], "additional_components": [ "Q54WR7", "DDB_G0279477", "Q76NU4", "DDB_G0277397", "Q55FK2", "DDB_G0268068", "species_29420", "Q55FK2", "DDB_G0268068", "species_29438", "Q54WR7", "DDB_G0279477", "Q76NU4", "DDB_G0277397", "Q54WR7", "DDB_G0279477", "Q76NU4", "DDB_G0277397", "Q55FK2", "DDB_G0268068", "species_29420" ] }, "reaction_10618359": { "compartment": "compartment_263163", "id": "reaction_10618359", "reactome": "R-DDI-8847537", "name": "RAB43:GTP binds USP8NL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618357", "species_10618342" ], "products": [ "species_10618344" ], "modifiers": [], "additional_components": [ "Q54Z16", "DDB_G0289735", "Q54H32", "DDB_G0289735", "Q54SD0", "DDB_G0282537", "species_29438", "Q54SD0", "DDB_G0282537", "species_29438", "Q54H32", "DDB_G0289735", "Q54Z16", "DDB_G0289735" ] }, "reaction_10618312": { "compartment": "compartment_263163", "id": "reaction_10618312", "reactome": "R-DDI-6814684", "name": "cis-SNARE binds SNAPs and NSF hexamer at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611694", "species_10611703", "species_10618308" ], "products": [ "species_10618310" ], "modifiers": [], "additional_components": [ "Q75JI3", "DDB_G0276153", "Q54NP6", "DDB_G0285111", "Q54I20", "DDB_G0289063", "Q54PW2", "DDB_G0284185", "Q54PQ5", "DDB_G0289063", "Q54CK6", "DDB_G0292974", "Q553C3", "DDB_G0275765", "Q54R67", "DDB_G0283363", "Q551H5", "DDB_G0276575", "Q54I20", "DDB_G0289063", "Q54PW2", "DDB_G0284185", "Q54PQ5", "DDB_G0289063", "Q54CK6", "DDB_G0292974", "Q553C3", "DDB_G0275765", "Q54R67", "DDB_G0283363", "Q551H5", "DDB_G0276575", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153" ] }, "reaction_10618351": { "compartment": "compartment_263163", "id": "reaction_10618351", "reactome": "R-DDI-8847534", "name": "RAB43 hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618344" ], "products": [ "species_10618348" ], "modifiers": [ [ "species_10618344", "catalyst" ] ], "additional_components": [ "Q54SD0", "DDB_G0282537", "species_29438", "Q54H32", "DDB_G0289735", "Q54Z16", "DDB_G0289735", "Q54SD0", "DDB_G0282537", "species_29420", "Q54H32", "DDB_G0289735", "Q54Z16", "DDB_G0289735", "Q54SD0", "DDB_G0282537", "species_29438", "Q54H32", "DDB_G0289735", "Q54Z16", "DDB_G0289735" ] }, "reaction_10617852": { "compartment": "compartment_263163", "id": "reaction_10617852", "reactome": "R-DDI-6814086", "name": "ARFRP1 recruits ARL1 to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617836", "species_10617844" ], "products": [ "species_10617850" ], "modifiers": [], "additional_components": [ "Q55E69", "DDB_G0269368", "Q54QU7", "DDB_G0283631", "species_29438", "Q54JB7", "DDB_G0288163", "species_29438", "Q54JB7", "DDB_G0288163", "species_29438", "Q55E69", "DDB_G0269368", "Q54QU7", "DDB_G0283631" ] }, "reaction_10617869": { "compartment": "compartment_263163", "id": "reaction_10617869", "reactome": "R-DDI-6814091", "name": "ARL1 recruits TGN Golgin homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617865", "species_10617850" ], "products": [ "species_10617867" ], "modifiers": [], "additional_components": [ "Q556B3", "DDB_G0274785", "Q54JB7", "DDB_G0288163", "species_29438", "Q55E69", "DDB_G0269368", "Q54QU7", "DDB_G0283631", "Q54JB7", "DDB_G0288163", "species_29438", "Q55E69", "DDB_G0269368", "Q54QU7", "DDB_G0283631", "Q556B3", "DDB_G0274785" ] }, "reaction_10618269": { "compartment": "compartment_263163", "id": "reaction_10618269", "reactome": "R-DDI-6814676", "name": "SNAPs and NSF hexamer bind cis-SNARE at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611694", "species_10611703", "species_10618103" ], "products": [ "species_10618267" ], "modifiers": [], "additional_components": [ "Q75JI3", "DDB_G0276153", "Q54NP6", "DDB_G0285111", "Q54CK6", "DDB_G0292974", "Q553C3", "DDB_G0275765", "Q54R67", "DDB_G0283363", "Q54I20", "DDB_G0289063", "Q551H5", "DDB_G0276575", "Q54GB3", "DDB_G0290363", "Q54CK6", "DDB_G0292974", "Q553C3", "DDB_G0275765", "Q54R67", "DDB_G0283363", "Q54I20", "DDB_G0289063", "Q551H5", "DDB_G0276575", "Q54GB3", "DDB_G0290363", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153" ] }, "reaction_10623407": { "compartment": "compartment_70616", "id": "reaction_10623407", "reactome": "R-DDI-8949178", "name": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8949232" ], "products": [ "species_8949220" ], "modifiers": [ [ "species_10623404", "catalyst" ] ], "additional_components": [ "Q54JS1", "DDB_G0287825", "Q54LT0", "DDB_G0286429" ] }, "reaction_10592489": { "compartment": "compartment_876", "id": "reaction_10592489", "reactome": "R-DDI-442422", "name": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10592486", "catalyst" ] ], "additional_components": [ "Q55EA1", "DDB_G0269326", "Q54MB9", "DDB_G0286049" ] }, "reaction_10583681": { "compartment": "compartment_7660", "id": "reaction_10583681", "reactome": "R-DDI-156678", "name": "Activation of Cdc25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10583669" ], "products": [ "species_29370", "species_10583672" ], "modifiers": [ [ "species_10583678", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "DDB_G0274503" ] }, "reaction_10583700": { "compartment": "compartment_7660", "id": "reaction_10583700", "reactome": "R-DDI-156699", "name": "Inactivation of Wee1 kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10577525" ], "products": [ "species_113582", "species_10583695" ], "modifiers": [ [ "species_10583697", "catalyst" ] ], "additional_components": [ "DDB_G0277539", "DDB_G0277539", "DDB_G0274503" ] }, "reaction_10583863": { "compartment": "compartment_7660", "id": "reaction_10583863", "reactome": "R-DDI-162657", "name": "Inactivation of Myt1 kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10583858" ], "products": [ "species_113582", "species_10583861" ], "modifiers": [ [ "species_10583697", "catalyst" ] ], "additional_components": [ "DDB_G0291133", "DDB_G0291133", "DDB_G0274503" ] }, "reaction_10600890": { "compartment": "compartment_984", "id": "reaction_10600890", "reactome": "R-DDI-2328033", "name": "Fibrillin-1 binds latent TGF-beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600886", "species_10600215" ], "products": [ "species_10600888" ], "modifiers": [], "additional_components": [ "Q559U0", "DDB_G0278613", "Q54YP0", "DDB_G0278613", "Q54IA3", "DDB_G0295485", "B0G154", "DDB_G0295485", "Q54IA3", "DDB_G0295485", "B0G154", "DDB_G0295485", "Q559U0", "DDB_G0278613", "Q54YP0", "DDB_G0278613" ] }, "reaction_10600223": { "compartment": "compartment_984", "id": "reaction_10600223", "reactome": "R-DDI-2129362", "name": "Fibrillin microfibril assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600193" ], "products": [ "species_10600221" ], "modifiers": [], "additional_components": [ "Q54IA3", "DDB_G0295485", "B0G154", "DDB_G0295485", "Q54IA3", "DDB_G0295485", "B0G154", "DDB_G0295485" ] }, "reaction_10601589": { "compartment": "compartment_70101", "id": "reaction_10601589", "reactome": "R-DDI-2730896", "name": "Phosphorylation of MEK4 by MEKK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10593048" ], "products": [ "species_29370", "species_10593058" ], "modifiers": [ [ "species_10601580", "catalyst" ] ], "additional_components": [ "DDB_G0289277", "DDB_G0289277", "Q54PX0", "DDB_G0284251", "Q55CA6", "DDB_G0284251", "Q8T2I8", "DDB_G0276465" ] }, "reaction_10601583": { "compartment": "compartment_70101", "id": "reaction_10601583", "reactome": "R-DDI-2730868", "name": "Phosphorylation of MEK7 by MEKK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10593046" ], "products": [ "species_10593054", "species_29370" ], "modifiers": [ [ "species_10601580", "catalyst" ] ], "additional_components": [ "DDB_G0289277", "DDB_G0289277", "Q54PX0", "DDB_G0284251", "Q55CA6", "DDB_G0284251", "Q8T2I8", "DDB_G0276465" ] }, "reaction_10626182": { "compartment": "compartment_70101", "id": "reaction_10626182", "reactome": "R-DDI-9619355", "name": "CaMKK autophosphorylates in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626175", "species_113592" ], "products": [ "species_29370", "species_10626179" ], "modifiers": [ [ "species_10626175", "catalyst" ] ], "additional_components": [ "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "Q55CW1", "DDB_G0270680", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "Q55CW1", "DDB_G0270680", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "Q55CW1", "DDB_G0270680" ] }, "reaction_10626191": { "compartment": "compartment_70101", "id": "reaction_10626191", "reactome": "R-DDI-9619376", "name": "CAMK1 binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626187", "species_10583042" ], "products": [ "species_10626189" ], "modifiers": [], "additional_components": [ "DDB_G0279925", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "P25323", "DDB_G0279925" ] }, "reaction_10585189": { "compartment": "compartment_70101", "id": "reaction_10585189", "reactome": "R-DDI-174054", "name": "Formation of Cyclin A:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577493", "species_10584819" ], "products": [ "species_10585187" ], "modifiers": [], "additional_components": [ "DDB_G0272813", "P34112", "DDB_G0272813" ] }, "reaction_10585460": { "compartment": "compartment_13231", "id": "reaction_10585460", "reactome": "R-DDI-174273", "name": "Translocation of Cyclin A:Cdk2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585187" ], "products": [ "species_10585380" ], "modifiers": [], "additional_components": [ "P34112", "DDB_G0272813", "P34112", "DDB_G0272813" ] }, "reaction_10585924": { "compartment": "compartment_7660", "id": "reaction_10585924", "reactome": "R-DDI-187948", "name": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10585920" ], "products": [ "species_113582", "species_10585922" ], "modifiers": [ [ "species_10576705", "catalyst" ] ], "additional_components": [ "Q54FX2", "DDB_G0290551", "Q54KM3", "DDB_G0287259", "Q54FX2", "DDB_G0290551", "Q54KM3", "DDB_G0287259", "P34112", "DDB_G0272813" ] }, "reaction_10585927": { "compartment": "compartment_7660", "id": "reaction_10585927", "reactome": "R-DDI-187949", "name": "CAK-mediated phosphorylation of Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10585380" ], "products": [ "species_113582", "species_10576705" ], "modifiers": [ [ "species_10580662", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "P34112", "DDB_G0272813", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668" ] }, "reaction_10585382": { "compartment": "compartment_7660", "id": "reaction_10585382", "reactome": "R-DDI-174110", "name": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10585378" ], "products": [ "species_113550", "species_10585380" ], "modifiers": [ [ "species_10577539", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "P34112", "DDB_G0272813", "DDB_G0283617" ] }, "reaction_10585914": { "compartment": "compartment_7660", "id": "reaction_10585914", "reactome": "R-DDI-187574", "name": "Degradation of ubiquitinated p27/p21 by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585912" ], "products": [ "species_10577273", "species_10585908", "species_10576865" ], "modifiers": [ [ "species_10585327", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "B0G102", "DDB_G0271642", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "B0G102", "DDB_G0271642", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q27563", "DDB_G0267408", "P02889", "DDB_G0272564", "P34119", "DDB_G0280969", "Q552Y8", "DDB_G0275753", "Q55G04", "DDB_G0268538", "Q967U1", "DDB_G0285099", "Q54XM7", "DDB_G0278847", "P34120", "DDB_G0272831", "Q86A21", "DDB_G0272969", "Q54S82", "DDB_G0282617", "Q54QR2", "DDB_G0283679", "Q55DY7", "DDB_G0269472", "Q55D66", "DDB_G0269772", "Q556Q0", "DDB_G0273163", "Q54BC8", "DDB_G0293784", "Q55GJ6", "DDB_G0267390", "Q55BV5", "DDB_G0270784", "Q86JA1", "DDB_G0276917", "Q54PN7", "DDB_G0284415", "P34123", "DDB_G0289003", "P34124", "DDB_G0292382", "Q54PJ1", "DDB_G0284517", "Q54JM5", "DDB_G0287953", "Q54HW1", "DDB_G0289189", "Q54UB5", "DDB_G0281315", "Q54UJ0", "DDB_G0281051", "Q54NQ0", "DDB_G0285105", "Q54BC6", "DDB_G0293752", "Q1ZXD3", "DDB_G0288621", "Q553E0", "DDB_G0275775", "Q86IJ1", "DDB_G0272566", "Q559F4", "DDB_G0272951", "Q27562", "DDB_G0282363", "Q55C75", "DDB_G0270188", "Q54DM7", "DDB_G0292122", "Q54WI8", "DDB_G0279633" ] }, "reaction_10585439": { "compartment": "compartment_7660", "id": "reaction_10585439", "reactome": "R-DDI-174164", "name": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10585380" ], "products": [ "species_113582", "species_10585378" ], "modifiers": [ [ "species_10577525", "catalyst" ], [ "species_10577531", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "P34112", "DDB_G0272813", "DDB_G0277539", "DDB_G0302543" ] }, "reaction_10601123": { "compartment": "compartment_7660", "id": "reaction_10601123", "reactome": "R-DDI-2468039", "name": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601103", "species_113560" ], "products": [ "species_2485002", "species_10601111" ], "modifiers": [ [ "species_10601120", "catalyst" ] ], "additional_components": [ "Q54QR0", "DDB_G0283681", "Q54E85", "DDB_G0291752", "Q552D9", "DDB_G0276101", "Q550H7", "DDB_G0276977", "Q552Q7", "DDB_G0275929", "Q54QR0", "DDB_G0283681", "Q552D9", "DDB_G0276101", "Q54E85", "DDB_G0291752", "Q550H7", "DDB_G0276977", "Q552Q7", "DDB_G0275929", "Q54W25", "DDB_G0279959" ] }, "reaction_10601155": { "compartment": "compartment_7660", "id": "reaction_10601155", "reactome": "R-DDI-2473152", "name": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601151", "species_113560" ], "products": [ "species_2485002", "species_10601153" ], "modifiers": [ [ "species_10601120", "catalyst" ] ], "additional_components": [ "Q54QR0", "DDB_G0283681", "Q54E85", "DDB_G0291752", "Q552D9", "DDB_G0276101", "Q550H7", "DDB_G0276977", "Q552Q7", "DDB_G0275929", "Q54QR0", "DDB_G0283681", "Q552D9", "DDB_G0276101", "Q54E85", "DDB_G0291752", "Q550H7", "DDB_G0276977", "Q552Q7", "DDB_G0275929", "Q54W25", "DDB_G0279959" ] }, "reaction_10585939": { "compartment": "compartment_7660", "id": "reaction_10585939", "reactome": "R-DDI-187959", "name": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10585916" ], "products": [ "species_113582", "species_10585936" ], "modifiers": [ [ "species_10585916", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q54Q23", "DDB_G0284129", "P34112", "DDB_G0272813", "Q54Q23", "DDB_G0284129", "P34112", "DDB_G0272813", "Q54Q23", "DDB_G0284129" ] }, "reaction_10585918": { "compartment": "compartment_7660", "id": "reaction_10585918", "reactome": "R-DDI-187937", "name": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576524", "species_10576705" ], "products": [ "species_10585916" ], "modifiers": [], "additional_components": [ "Q54Q23", "DDB_G0284129", "P34112", "DDB_G0272813", "P34112", "DDB_G0272813", "Q54Q23", "DDB_G0284129" ] }, "reaction_10619259": { "compartment": "compartment_70101", "id": "reaction_10619259", "reactome": "R-DDI-8854041", "name": "SCF-FBXL7 ubiquitinates AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10619191" ], "products": [ "species_10619256" ], "modifiers": [ [ "species_10619191", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54WX4", "DDB_G0279343", "Q54WX4", "DDB_G0279343", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54WX4", "DDB_G0279343" ] }, "reaction_10619193": { "compartment": "compartment_70101", "id": "reaction_10619193", "reactome": "R-DDI-8853496", "name": "SCF:FBXL7 binds AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585350", "species_10619189" ], "products": [ "species_10619191" ], "modifiers": [], "additional_components": [ "DDB_G0279343", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54WX4", "DDB_G0279343" ] }, "reaction_10619261": { "compartment": "compartment_70101", "id": "reaction_10619261", "reactome": "R-DDI-8854044", "name": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619256" ], "products": [ "species_10577037", "species_10619189" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q54WX4", "DDB_G0279343", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10584837": { "compartment": "compartment_13231", "id": "reaction_10584837", "reactome": "R-DDI-170159", "name": "Translocation of Cdc25 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584833" ], "products": [ "species_10584835" ], "modifiers": [], "additional_components": [ "Q54QM6", "DDB_G0283617", "Q54QM6", "DDB_G0283617" ] }, "reaction_10619653": { "compartment": "compartment_7660", "id": "reaction_10619653", "reactome": "R-DDI-8856951", "name": "PP2A demethylation by PPME1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10619637" ], "products": [ "species_10597550", "species_8857797" ], "modifiers": [ [ "species_10619650", "catalyst" ] ], "additional_components": [ "DDB_G0281651" ] }, "reaction_10584825": { "compartment": "compartment_13231", "id": "reaction_10584825", "reactome": "R-DDI-170120", "name": "Translocation of Cdc25B to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584821" ], "products": [ "species_10584823" ], "modifiers": [], "additional_components": [ "DDB_G0283617", "DDB_G0283617" ] }, "reaction_10584829": { "compartment": "compartment_13231", "id": "reaction_10584829", "reactome": "R-DDI-170149", "name": "Translocation of active Cdc25C to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583672" ], "products": [ "species_10584827" ], "modifiers": [], "additional_components": [ "DDB_G0283617", "DDB_G0283617" ] }, "reaction_10619645": { "compartment": "compartment_7660", "id": "reaction_10619645", "reactome": "R-DDI-8856945", "name": "PP2A methylation by LCMT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597550", "species_77087" ], "products": [ "species_77502", "species_10619637" ], "modifiers": [ [ "species_10619642", "catalyst" ] ], "additional_components": [ "DDB_G0288271" ] }, "reaction_10601941": { "compartment": "compartment_70101", "id": "reaction_10601941", "reactome": "R-DDI-3002798", "name": "Cytosolic PLK1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583678" ], "products": [ "species_10583697" ], "modifiers": [], "additional_components": [ "DDB_G0274503", "DDB_G0274503" ] }, "reaction_10601061": { "compartment": "compartment_70101", "id": "reaction_10601061", "reactome": "R-DDI-2467775", "name": "Autocleavage of ESPL1 (Separase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601050" ], "products": [ "species_10601058" ], "modifiers": [ [ "species_10601050", "catalyst" ] ], "additional_components": [ "DDB_G0290325", "Q54G81", "DDB_G0290325", "DDB_G0290325" ] }, "reaction_10600560": { "compartment": "compartment_7660", "id": "reaction_10600560", "reactome": "R-DDI-2168079", "name": "MASTL (GWL) phosphorylates ARPP19", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10600546" ], "products": [ "species_113582", "species_10600549" ], "modifiers": [ [ "species_10600557", "catalyst" ] ], "additional_components": [ "DDB_G0283571", "DDB_G0283571", "DDB_G0272282" ] }, "reaction_10600987": { "compartment": "compartment_7660", "id": "reaction_10600987", "reactome": "R-DDI-2430535", "name": "MASTL phosphorylates ENSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10600982" ], "products": [ "species_113582", "species_10600985" ], "modifiers": [ [ "species_10600557", "catalyst" ] ], "additional_components": [ "DDB_G0283571", "DDB_G0283571", "DDB_G0272282" ] }, "reaction_10600815": { "compartment": "compartment_20699", "id": "reaction_10600815", "reactome": "R-DDI-2214351", "name": "PLK1 phosphorylates GORASP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10600807" ], "products": [ "species_10600812", "species_29370" ], "modifiers": [ [ "species_10600807", "catalyst" ] ], "additional_components": [ "P34139", "DDB_G0283757", "species_29438", "Q54C46", "DDB_G0293248", "Q86HN7", "DDB_G0274503", "P34139", "DDB_G0283757", "species_29438", "Q54C46", "DDB_G0293248", "Q86HN7", "DDB_G0274503", "P34139", "DDB_G0283757", "species_29438", "Q54C46", "DDB_G0293248", "Q86HN7", "DDB_G0274503" ] }, "reaction_10585968": { "compartment": "compartment_7660", "id": "reaction_10585968", "reactome": "R-DDI-188390", "name": "Cyclin E:CDK2-mediated phosphorylation of RB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10585963" ], "products": [ "species_113582", "species_10577271", "species_10583328" ], "modifiers": [ [ "species_10585963", "catalyst" ] ], "additional_components": [ "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "P34112", "DDB_G0272813", "Q54FX2", "DDB_G0290551", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "P34112", "DDB_G0272813", "DDB_G0290551", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "P34112", "DDB_G0272813", "Q54FX2", "DDB_G0290551" ] }, "reaction_10577511": { "compartment": "compartment_70101", "id": "reaction_10577511", "reactome": "R-DDI-69191", "name": "Formation of Cyclin E:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577493", "species_10577507" ], "products": [ "species_10577509" ], "modifiers": [], "additional_components": [ "DDB_G0272813", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "P34112", "DDB_G0272813" ] }, "reaction_10585959": { "compartment": "compartment_7660", "id": "reaction_10585959", "reactome": "R-DDI-188350", "name": "CAK-mediated phosphorylation of Cyclin E:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10577515" ], "products": [ "species_113582", "species_10577271" ], "modifiers": [ [ "species_10580662", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "P34112", "DDB_G0272813", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668" ] }, "reaction_10577542": { "compartment": "compartment_7660", "id": "reaction_10577542", "reactome": "R-DDI-69199", "name": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10577520" ], "products": [ "species_113550", "species_10577515" ], "modifiers": [ [ "species_10577539", "catalyst" ] ], "additional_components": [ "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "P34112", "DDB_G0272813", "P34112", "DDB_G0272813", "DDB_G0283617" ] }, "reaction_10577533": { "compartment": "compartment_7660", "id": "reaction_10577533", "reactome": "R-DDI-69195", "name": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10577515" ], "products": [ "species_113582", "species_10577520" ], "modifiers": [ [ "species_10577525", "catalyst" ], [ "species_10577531", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "P34112", "DDB_G0272813", "DDB_G0277539", "DDB_G0302543" ] }, "reaction_10585965": { "compartment": "compartment_7660", "id": "reaction_10585965", "reactome": "R-DDI-188386", "name": "Association of Rb with Cyclin E:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577550", "species_10577271" ], "products": [ "species_10585963" ], "modifiers": [], "additional_components": [ "DDB_G0290551", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "P34112", "DDB_G0272813", "Q54FX2", "DDB_G0290551" ] }, "reaction_10583775": { "compartment": "compartment_13231", "id": "reaction_10583775", "reactome": "R-DDI-157906", "name": "Translocation of Cyclin E:Cdk2 complex to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577509" ], "products": [ "species_10577515" ], "modifiers": [], "additional_components": [ "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "P34112", "DDB_G0272813", "P34112", "DDB_G0272813" ] }, "reaction_10583356": { "compartment": "compartment_7660", "id": "reaction_10583356", "reactome": "R-DDI-113503", "name": "PP2A mediated localization of RB1 protein in chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_113656", "species_10583328" ], "products": [ "species_113550", "species_10583330" ], "modifiers": [ [ "species_10583353", "catalyst" ] ], "additional_components": [ "DDB_G0290551", "Q54FX2", "DDB_G0290551", "Q54W95", "DDB_G0279813" ] }, "reaction_10583358": { "compartment": "compartment_7660", "id": "reaction_10583358", "reactome": "R-DDI-113504", "name": "Detection of damage during initiation of DNA synthesis in S-phase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577245" ], "products": [ "species_10576604", "species_113656" ], "modifiers": [], "additional_components": [ "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731" ] }, "reaction_10627090": { "compartment": "compartment_70101", "id": "reaction_10627090", "reactome": "R-DDI-9659820", "name": "RB1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627088" ], "products": [ "species_10577547" ], "modifiers": [], "additional_components": [ "DDB_G0290551", "DDB_G0290551" ] }, "reaction_10625026": { "compartment": "compartment_7660", "id": "reaction_10625026", "reactome": "R-DDI-9018017", "name": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577547", "species_10602086" ], "products": [ "species_10625024" ], "modifiers": [ [ "species_10577271", "inhibitor" ] ], "additional_components": [ "DDB_G0290551", "Q54Q23", "DDB_G0284129", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "Q7KWP1", "DDB_G0276799", "Q54FX2", "DDB_G0290551", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "P34112", "DDB_G0272813" ] }, "reaction_10597553": { "compartment": "compartment_7660", "id": "reaction_10597553", "reactome": "R-DDI-1363274", "name": "Dephosphorylation of p107 (RBL1) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10597263" ], "products": [ "species_113550", "species_10597255" ], "modifiers": [ [ "species_10597550", "catalyst" ] ], "additional_components": [ "DDB_G0290551", "DDB_G0290551" ] }, "reaction_10597584": { "compartment": "compartment_7660", "id": "reaction_10597584", "reactome": "R-DDI-1363331", "name": "Ubiquitination of p130 (RBL2) by SCF (Skp2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597577", "species_10576865" ], "products": [ "species_10597581", "species_10585908" ], "modifiers": [ [ "species_10597577", "catalyst" ] ], "additional_components": [ "Q54FX2", "DDB_G0290551", "B0G102", "DDB_G0271642", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54FX2", "DDB_G0290551", "B0G102", "DDB_G0271642", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54FX2", "DDB_G0290551", "B0G102", "DDB_G0271642", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972" ] }, "reaction_10597555": { "compartment": "compartment_7660", "id": "reaction_10597555", "reactome": "R-DDI-1363276", "name": "Dephosphorylation of p130 (RBL2) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10597251" ], "products": [ "species_113550", "species_10597229" ], "modifiers": [ [ "species_10597550", "catalyst" ] ], "additional_components": [ "DDB_G0290551", "DDB_G0290551" ] }, "reaction_10597579": { "compartment": "compartment_7660", "id": "reaction_10597579", "reactome": "R-DDI-1363328", "name": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585908", "species_10597251" ], "products": [ "species_10597577" ], "modifiers": [], "additional_components": [ "B0G102", "DDB_G0271642", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "DDB_G0290551", "Q54FX2", "DDB_G0290551", "B0G102", "DDB_G0271642", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972" ] }, "reaction_10600926": { "compartment": "compartment_984", "id": "reaction_10600926", "reactome": "R-DDI-2396337", "name": "HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600922", "species_10598295" ], "products": [ "species_10600924" ], "modifiers": [], "additional_components": [ "Q54LD6", "DDB_G0286691", "DDB_G0270488", "Q55E77", "DDB_G0270488", "Q54LD6", "DDB_G0286691" ] }, "reaction_10603454": { "compartment": "compartment_984", "id": "reaction_10603454", "reactome": "R-DDI-4084505", "name": "Laminins bind HSPG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603450", "species_10598295" ], "products": [ "species_10603452" ], "modifiers": [], "additional_components": [ "Q55E77", "DDB_G0270488", "DDB_G0270488", "Q55E77", "DDB_G0270488" ] }, "reaction_10626256": { "compartment": "compartment_876", "id": "reaction_10626256", "reactome": "R-DDI-9625814", "name": "SPHK1 phosphorylates sphingosine in response to E2 stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1606609" ], "products": [ "species_5218688" ], "modifiers": [ [ "species_10590508", "catalyst" ] ], "additional_components": [ "DDB_G0284545" ] }, "reaction_10582777": { "compartment": "compartment_7660", "id": "reaction_10582777", "reactome": "R-DDI-110322", "name": "Formation of Pol zeta complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582773", "species_10582768" ], "products": [ "species_10582775" ], "modifiers": [], "additional_components": [ "DDB_G0282747", "DDB_G0271608", "Q55AZ3", "DDB_G0271608", "Q54S00", "DDB_G0282747" ] }, "reaction_10594097": { "compartment": "compartment_70101", "id": "reaction_10594097", "reactome": "R-DDI-727767", "name": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727746" ], "products": [ "species_727782" ], "modifiers": [ [ "species_10594084", "catalyst" ] ], "additional_components": [ "species_83909", "species_83921", "CHEBI:16750", "CHEBI:16704", "species_83928", "CHEBI:17562", "species_5635947", "species_83909", "species_83921", "CHEBI:16704", "CHEBI:16750", "CHEBI:17562", "species_83928", "species_5635947", "Q54TT2", "DDB_G0283439", "Q54TT3", "DDB_G0283439", "Q54R17", "DDB_G0283439" ] }, "reaction_10594099": { "compartment": "compartment_70101", "id": "reaction_10594099", "reactome": "R-DDI-727768", "name": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727737" ], "products": [ "species_727774" ], "modifiers": [ [ "species_10594073", "catalyst" ] ], "additional_components": [ "species_159362", "CHEBI:28918", "species_83909", "species_209914", "species_209789", "species_209789", "species_83909", "species_209914", "species_159362", "CHEBI:28918", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0283439", "Q54TT3", "DDB_G0283439" ] }, "reaction_10582532": { "compartment": "compartment_70101", "id": "reaction_10582532", "reactome": "R-DDI-109534", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179743" ], "products": [ "species_179737" ], "modifiers": [ [ "species_10582529", "catalyst" ] ], "additional_components": [ "species_83909", "species_83921", "CHEBI:16750", "CHEBI:16704", "species_83928", "CHEBI:17562", "species_83921", "CHEBI:16750", "CHEBI:16704", "species_83928", "species_83909", "CHEBI:17562", "Q54R17", "DDB_G0283439" ] }, "reaction_10582534": { "compartment": "compartment_70101", "id": "reaction_10582534", "reactome": "R-DDI-109536", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179737" ], "products": [ "species_179743" ], "modifiers": [ [ "species_10582529", "catalyst" ] ], "additional_components": [ "species_83921", "CHEBI:16750", "CHEBI:16704", "species_83928", "species_83909", "CHEBI:17562", "species_83909", "species_83921", "CHEBI:16750", "CHEBI:16704", "species_83928", "CHEBI:17562", "Q54R17", "DDB_G0283439" ] }, "reaction_10584043": { "compartment": "compartment_70616", "id": "reaction_10584043", "reactome": "R-DDI-163215", "name": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_113593" ], "products": [ "species_113581", "species_113592" ], "modifiers": [ [ "species_10584040", "catalyst" ] ], "additional_components": [ "O97470", "DDB_G0267454" ] }, "reaction_10582525": { "compartment": "compartment_70101", "id": "reaction_10582525", "reactome": "R-DDI-109527", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179747" ], "products": [ "species_179742" ], "modifiers": [ [ "species_10582522", "catalyst" ] ], "additional_components": [ "species_83921", "CHEBI:16750", "species_83956", "CHEBI:16704", "species_83928", "species_113599", "species_83909", "species_83960", "species_29554", "species_5635947", "CHEBI:17562", "CHEBI:16040", "species_83909", "CHEBI:16040", "species_83956", "species_83921", "CHEBI:16750", "CHEBI:16704", "species_83928", "species_83960", "species_29554", "CHEBI:17562", "species_5635947", "species_113599", "Q54TT3", "DDB_G0283439", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0283439" ] }, "reaction_10594076": { "compartment": "compartment_70101", "id": "reaction_10594076", "reactome": "R-DDI-727740", "name": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727774" ], "products": [ "species_727737" ], "modifiers": [ [ "species_10594073", "catalyst" ] ], "additional_components": [ "species_209789", "species_83909", "species_209914", "species_159362", "CHEBI:28918", "species_159362", "CHEBI:28918", "species_83909", "species_209914", "species_209789", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0283439", "Q54TT3", "DDB_G0283439" ] }, "reaction_10582527": { "compartment": "compartment_70101", "id": "reaction_10582527", "reactome": "R-DDI-109529", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179742" ], "products": [ "species_179747" ], "modifiers": [ [ "species_10582522", "catalyst" ] ], "additional_components": [ "species_83909", "CHEBI:16040", "species_83956", "species_83921", "CHEBI:16750", "CHEBI:16704", "species_83928", "species_83960", "species_29554", "CHEBI:17562", "species_5635947", "species_113599", "species_83921", "CHEBI:16750", "species_83956", "CHEBI:16704", "species_83928", "species_113599", "species_83909", "species_83960", "species_29554", "species_5635947", "CHEBI:17562", "CHEBI:16040", "Q54TT3", "DDB_G0283439", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0283439" ] }, "reaction_10594129": { "compartment": "compartment_20699", "id": "reaction_10594129", "reactome": "R-DDI-742354", "name": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162756" ], "products": [ "species_914003" ], "modifiers": [ [ "species_10594126", "catalyst" ] ], "additional_components": [ "DDB_G0275061" ] }, "reaction_10594132": { "compartment": "compartment_20699", "id": "reaction_10594132", "reactome": "R-DDI-742373", "name": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742353" ], "products": [ "species_742361" ], "modifiers": [ [ "species_10594126", "catalyst" ] ], "additional_components": [ "DDB_G0275061" ] }, "reaction_10594095": { "compartment": "compartment_20699", "id": "reaction_10594095", "reactome": "R-DDI-727759", "name": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183" ], "products": [ "species_727753" ], "modifiers": [ [ "species_10594092", "catalyst" ] ], "additional_components": [ "DDB_G0278059" ] }, "reaction_10620690": { "compartment": "compartment_876", "id": "reaction_10620690", "reactome": "R-DDI-8870354", "name": "SLC36A4 transports extracellular L-Pro to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352033" ], "products": [ "species_113538" ], "modifiers": [ [ "species_10620684", "catalyst" ] ], "additional_components": [ "DDB_G0293074" ] }, "reaction_10589664": { "compartment": "compartment_876", "id": "reaction_10589664", "reactome": "R-DDI-375768", "name": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10589661", "catalyst" ] ], "additional_components": [ "species_29444", "species_29468", "species_29468", "species_29444", "Q54KK4", "DDB_G0346922", "Q54F04", "DDB_G0346922", "Q54KK2", "DDB_G0346922", "Q54KK5", "DDB_G0346922", "Q54W03", "DDB_G0346922", "Q54EJ9", "DDB_G0291227", "Q54KK3", "DDB_G0346922" ] }, "reaction_10589683": { "compartment": "compartment_876", "id": "reaction_10589683", "reactome": "R-DDI-375770", "name": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10589680", "catalyst" ] ], "additional_components": [ "species_29444", "species_29468", "species_29468", "species_29444", "Q54EJ9", "DDB_G0291227", "Q54F04", "DDB_G0346922", "Q54KK2", "DDB_G0346922", "Q54KK3", "DDB_G0346922", "Q54KK4", "DDB_G0346922", "Q54KK5", "DDB_G0346922", "Q54W03", "DDB_G0346922" ] }, "reaction_10589702": { "compartment": "compartment_876", "id": "reaction_10589702", "reactome": "R-DDI-375776", "name": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10589699", "catalyst" ] ], "additional_components": [ "species_29444", "species_29468", "species_29468", "species_29444", "Q54W03", "DDB_G0346922", "Q54EJ9", "DDB_G0291227", "Q54F04", "DDB_G0346922", "Q54KK2", "DDB_G0346922", "Q54KK3", "DDB_G0346922", "Q54KK4", "DDB_G0346922", "Q54KK5", "DDB_G0346922" ] }, "reaction_10589704": { "compartment": "compartment_876", "id": "reaction_10589704", "reactome": "R-DDI-375790", "name": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10589661", "catalyst" ] ], "additional_components": [ "species_29444", "species_29468", "species_29468", "species_29444", "Q54KK4", "DDB_G0346922", "Q54F04", "DDB_G0346922", "Q54KK2", "DDB_G0346922", "Q54KK5", "DDB_G0346922", "Q54W03", "DDB_G0346922", "Q54EJ9", "DDB_G0291227", "Q54KK3", "DDB_G0346922" ] }, "reaction_10624530": { "compartment": "compartment_7660", "id": "reaction_10624530", "reactome": "R-DDI-9007539", "name": "CHEK1 phosphorylates E2F6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10623848" ], "products": [ "species_113582", "species_10624528" ], "modifiers": [ [ "species_10577605", "catalyst" ] ], "additional_components": [ "DDB_G0284129", "DDB_G0284129", "DDB_G0279719" ] }, "reaction_10623920": { "compartment": "compartment_7660", "id": "reaction_10623920", "reactome": "R-DDI-8954056", "name": "E2F6 binds TFDP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597242", "species_10623848" ], "products": [ "species_10623918" ], "modifiers": [], "additional_components": [ "DDB_G0276799", "DDB_G0284129", "Q54Q23", "DDB_G0284129", "Q7KWP1", "DDB_G0276799" ] }, "reaction_10623931": { "compartment": "compartment_7660", "id": "reaction_10623931", "reactome": "R-DDI-8954117", "name": "E2F6:TFDP1 binds EPC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623850", "species_10623927" ], "products": [ "species_10623929" ], "modifiers": [], "additional_components": [ "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "DDB_G0287727", "Q54JZ0", "DDB_G0287727", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129" ] }, "reaction_10623852": { "compartment": "compartment_7660", "id": "reaction_10623852", "reactome": "R-DDI-8953111", "name": "E2F6 binds TFDP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623848", "species_10597240" ], "products": [ "species_10623850" ], "modifiers": [], "additional_components": [ "DDB_G0284129", "DDB_G0276799", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129" ] }, "reaction_10595753": { "compartment": "compartment_7660", "id": "reaction_10595753", "reactome": "R-DDI-975040", "name": "KRAB-ZNF / KAP Interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10595749", "species_10595441" ], "products": [ "species_10595751" ], "modifiers": [], "additional_components": [ "Q54UG9", "DDB_G0281085", "DDB_G0285989", "Q54MF7", "DDB_G0285989", "Q54UG9", "DDB_G0281085" ] }, "reaction_10612161": { "compartment": "compartment_7660", "id": "reaction_10612161", "reactome": "R-DDI-5696655", "name": "PARP1 or PARP2 PARylates DDB2 and autoPARylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612159", "species_427523" ], "products": [ "species_427497", "species_10611122" ], "modifiers": [], "additional_components": [ "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296", "Q54CS2", "DDB_G0292794", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820" ] }, "reaction_10612163": { "compartment": "compartment_7660", "id": "reaction_10612163", "reactome": "R-DDI-5696664", "name": "PARP1 or PARP2 binds DDB2 at GG-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612157", "species_10606233" ], "products": [ "species_10612159" ], "modifiers": [], "additional_components": [ "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296" ] }, "reaction_10611143": { "compartment": "compartment_7660", "id": "reaction_10611143", "reactome": "R-DDI-5691004", "name": "XPC binds RAD23 and CETN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603915", "species_10603976", "species_10611111" ], "products": [ "species_10611141" ], "modifiers": [], "additional_components": [ "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "DDB_G0292296", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q1ZXA6", "DDB_G0292296", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151" ] }, "reaction_10612471": { "compartment": "compartment_7660", "id": "reaction_10612471", "reactome": "R-DDI-6782943", "name": "UV-DDB ubiquitinates XPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611197", "species_10576865" ], "products": [ "species_10612157" ], "modifiers": [ [ "species_10611197", "catalyst" ] ], "additional_components": [ "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q1ZXA6", "DDB_G0292296", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q1ZXA6", "DDB_G0292296", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629" ] }, "reaction_10611199": { "compartment": "compartment_7660", "id": "reaction_10611199", "reactome": "R-DDI-5691006", "name": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611195", "species_10611141", "species_5688114" ], "products": [ "species_10611197", "species_10611193" ], "modifiers": [], "additional_components": [ "Q54PF3", "DDB_G0284597", "Q54QX3", "DDB_G0283587", "Q54HL6", "DDB_G0289361", "Q55BD5", "DDB_G0271282", "Q54E53", "DDB_G0291848", "Q54C92", "DDB_G0293180", "Q75K24", "DDB_G0275471", "Q54B82", "DDB_G0293844", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q1ZXA6", "DDB_G0292296", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q1ZXA6", "DDB_G0292296", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54PF3", "DDB_G0284597", "Q54QX3", "DDB_G0283587", "Q54HL6", "DDB_G0289361", "Q55BD5", "DDB_G0271282", "Q54E53", "DDB_G0291848", "Q54C92", "DDB_G0293180", "Q75K24", "DDB_G0275471", "Q54B82", "DDB_G0293844" ] }, "reaction_10611139": { "compartment": "compartment_7660", "id": "reaction_10611139", "reactome": "R-DDI-5691000", "name": "TFIIH binds GG-NER site to form a verification complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580699", "species_10611122" ], "products": [ "species_10611137" ], "modifiers": [], "additional_components": [ "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54CS2", "DDB_G0292794", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729" ] }, "reaction_10582642": { "compartment": "compartment_7660", "id": "reaction_10582642", "reactome": "R-DDI-109955", "name": "Formation of ERCC1:XPF heterodimeric complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582638", "species_10582633" ], "products": [ "species_10582640" ], "modifiers": [], "additional_components": [ "DDB_G0284419", "DDB_G0267682", "Q55GG6", "DDB_G0267682", "Q54PN5", "DDB_G0284419" ] }, "reaction_10612919": { "compartment": "compartment_7660", "id": "reaction_10612919", "reactome": "R-DDI-6790454", "name": "SUMOylation of XPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611132", "species_10612903" ], "products": [ "species_10601725", "species_10612914" ], "modifiers": [ [ "species_10612916", "catalyst" ] ], "additional_components": [ "O00835", "DDB_G0278729", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "Q55CT8", "DDB_G0269906", "Q55G81", "DDB_G0267414", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296", "Q54SX2", "DDB_G0282161", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "O00835", "DDB_G0278729", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "Q55CT8", "DDB_G0269906", "Q55G81", "DDB_G0267414", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q54CS2", "DDB_G0292794", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820" ] }, "reaction_10611135": { "compartment": "compartment_7660", "id": "reaction_10611135", "reactome": "R-DDI-5690996", "name": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611128" ], "products": [ "species_113550", "species_113582", "species_10611132" ], "modifiers": [ [ "species_10611128", "catalyst" ] ], "additional_components": [ "O00835", "DDB_G0278729", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "Q55CT8", "DDB_G0269906", "Q55G81", "DDB_G0267414", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q54CS2", "DDB_G0292794", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820", "O00835", "DDB_G0278729", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "Q55CT8", "DDB_G0269906", "Q55G81", "DDB_G0267414", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296", "O00835", "DDB_G0278729", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "Q55CT8", "DDB_G0269906", "Q55G81", "DDB_G0267414", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q54CS2", "DDB_G0292794", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820" ] }, "reaction_10611950": { "compartment": "compartment_7660", "id": "reaction_10611950", "reactome": "R-DDI-5696465", "name": "USP45 deubiquitinates ERCC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10611945" ], "products": [ "species_10582633", "species_10576865" ], "modifiers": [ [ "species_10611947", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55GG6", "DDB_G0267682", "DDB_G0267682", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0274207" ] }, "reaction_10612448": { "compartment": "compartment_7660", "id": "reaction_10612448", "reactome": "R-DDI-6782208", "name": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10612443" ], "products": [ "species_10612445", "species_113541" ], "modifiers": [ [ "species_10612443", "catalyst" ] ], "additional_components": [ "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54TY2", "DDB_G0281441", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "Q54KS3", "DDB_G0287149", "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MD4", "DDB_G0286027", "Q54MH9", "DDB_G0285961", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54TY2", "DDB_G0281441", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "Q54KS3", "DDB_G0287149", "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MD4", "DDB_G0286027", "Q54MH9", "DDB_G0285961", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54TY2", "DDB_G0281441", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "Q54KS3", "DDB_G0287149", "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MD4", "DDB_G0286027", "Q54MH9", "DDB_G0285961", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677" ] }, "reaction_10612419": { "compartment": "compartment_7660", "id": "reaction_10612419", "reactome": "R-DDI-6782141", "name": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612415", "species_10582640" ], "products": [ "species_10612417" ], "modifiers": [], "additional_components": [ "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54TY2", "DDB_G0281441", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q55GG6", "DDB_G0267682", "Q54PN5", "DDB_G0284419", "Q55GG6", "DDB_G0267682", "Q54PN5", "DDB_G0284419", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54TY2", "DDB_G0281441", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10627351": { "compartment": "compartment_7660", "id": "reaction_10627351", "reactome": "R-DDI-9684118", "name": "ERCC3-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10612392" ], "products": [ "species_113550", "species_113582", "species_10612403" ], "modifiers": [ [ "species_10612392", "catalyst" ] ], "additional_components": [ "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54TY2", "DDB_G0281441", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54TY2", "DDB_G0281441", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54TY2", "DDB_G0281441", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10612424": { "compartment": "compartment_7660", "id": "reaction_10612424", "reactome": "R-DDI-6782204", "name": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612417" ], "products": [ "species_10612421" ], "modifiers": [ [ "species_10612417", "catalyst" ] ], "additional_components": [ "Q55GG6", "DDB_G0267682", "Q54PN5", "DDB_G0284419", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54TY2", "DDB_G0281441", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q869U4", "DDB_G0276443", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q55GG6", "DDB_G0267682", "Q54PN5", "DDB_G0284419", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54TY2", "DDB_G0281441", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q55GG6", "DDB_G0267682", "Q54PN5", "DDB_G0284419", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54TY2", "DDB_G0281441", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10612456": { "compartment": "compartment_7660", "id": "reaction_10612456", "reactome": "R-DDI-6782211", "name": "DNA polymerases delta, epsilon or kappa bind the TC-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577420", "species_10612452", "species_10612421", "species_10612450" ], "products": [ "species_10612454" ], "modifiers": [], "additional_components": [ "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MD4", "DDB_G0286027", "Q54MH9", "DDB_G0285961", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q869U4", "DDB_G0276443", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q55GG6", "DDB_G0267682", "Q54PN5", "DDB_G0284419", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54TY2", "DDB_G0281441", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54KS3", "DDB_G0287149", "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q869U4", "DDB_G0276443", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q55GG6", "DDB_G0267682", "Q54PN5", "DDB_G0284419", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54K47", "DDB_G0287607", "Q54KS3", "DDB_G0287149", "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MD4", "DDB_G0286027", "Q54MH9", "DDB_G0285961", "Q54TY2", "DDB_G0281441", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10612395": { "compartment": "compartment_7660", "id": "reaction_10612395", "reactome": "R-DDI-6782131", "name": "ERCC2-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10612381" ], "products": [ "species_113550", "species_113582", "species_10612392" ], "modifiers": [ [ "species_10612381", "catalyst" ] ], "additional_components": [ "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54TY2", "DDB_G0281441", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54TY2", "DDB_G0281441", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54TY2", "DDB_G0281441", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10581574": { "compartment": "compartment_7660", "id": "reaction_10581574", "reactome": "R-DDI-75172", "name": "Formation of RAD50:MRE11 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581565", "species_10581570" ], "products": [ "species_10581572" ], "modifiers": [], "additional_components": [ "DDB_G0292786", "DDB_G0293546", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786" ] }, "reaction_10611351": { "compartment": "compartment_7660", "id": "reaction_10611351", "reactome": "R-DDI-5693536", "name": "ATM phosphorylates MDC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611348" ], "products": [ "species_113582", "species_10608053" ], "modifiers": [ [ "species_10611348", "catalyst" ] ], "additional_components": [ "Q86IG6", "DDB_G0272690", "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54Z32", "DDB_G0278587", "Q54F38", "DDB_G0291185", "Q54HV7", "DDB_G0289197", "Q76NW2", "DDB_G0276863", "Q86IG6", "DDB_G0272690", "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54Z32", "DDB_G0278587", "Q54F38", "DDB_G0291185", "Q54HV7", "DDB_G0289197", "Q76NW2", "DDB_G0276863", "Q86IG6", "DDB_G0272690", "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54Z32", "DDB_G0278587", "Q54F38", "DDB_G0291185", "Q54HV7", "DDB_G0289197", "Q76NW2", "DDB_G0276863" ] }, "reaction_10611386": { "compartment": "compartment_7660", "id": "reaction_10611386", "reactome": "R-DDI-5693583", "name": "MDC1 associates with gamma-H2AFX at nuclear foci", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608042", "species_10611346" ], "products": [ "species_10611348" ], "modifiers": [], "additional_components": [ "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54Z32", "DDB_G0278587", "Q54F38", "DDB_G0291185", "Q54HV7", "DDB_G0289197", "Q76NW2", "DDB_G0276863", "Q86IG6", "DDB_G0272690", "Q86IG6", "DDB_G0272690", "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54Z32", "DDB_G0278587", "Q54F38", "DDB_G0291185", "Q54HV7", "DDB_G0289197", "Q76NW2", "DDB_G0276863" ] }, "reaction_10611356": { "compartment": "compartment_7660", "id": "reaction_10611356", "reactome": "R-DDI-5693549", "name": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611353" ], "products": [ "species_113582", "species_10608103" ], "modifiers": [ [ "species_10611353", "catalyst" ] ], "additional_components": [ "Q54Z32", "DDB_G0278587", "Q54F38", "DDB_G0291185", "Q76NW2", "DDB_G0276863", "Q54HV7", "DDB_G0289197", "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54Z32", "DDB_G0278587", "Q54F38", "DDB_G0291185", "Q54HV7", "DDB_G0289197", "Q76NW2", "DDB_G0276863", "Q54Z32", "DDB_G0278587", "Q54F38", "DDB_G0291185", "Q76NW2", "DDB_G0276863", "Q54HV7", "DDB_G0289197", "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786" ] }, "reaction_10627073": { "compartment": "compartment_70101", "id": "reaction_10627073", "reactome": "R-DDI-9656947", "name": "OGG1beta translocates to mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627069" ], "products": [ "species_10627071" ], "modifiers": [], "additional_components": [ "DDB_G0292618", "DDB_G0292618" ] }, "reaction_10580816": { "compartment": "compartment_7660", "id": "reaction_10580816", "reactome": "R-DDI-73931", "name": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580809" ], "products": [ "species_10580813" ], "modifiers": [ [ "species_10580809", "catalyst" ] ], "additional_components": [ "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713" ] }, "reaction_10582803": { "compartment": "compartment_7660", "id": "reaction_10582803", "reactome": "R-DDI-110360", "name": "Recruitment of POLB to the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582796", "species_10580793" ], "products": [ "species_10582801" ], "modifiers": [], "additional_components": [ "P51173", "DDB_G0277701", "DDB_G0284713", "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701" ] }, "reaction_10582806": { "compartment": "compartment_7660", "id": "reaction_10582806", "reactome": "R-DDI-110375", "name": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582801" ], "products": [ "species_10582782", "species_10580820", "species_30977" ], "modifiers": [ [ "species_10582801", "catalyst" ] ], "additional_components": [ "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701", "DDB_G0277701", "Q1ZXF2", "DDB_G0284713", "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701" ] }, "reaction_10580825": { "compartment": "compartment_7660", "id": "reaction_10580825", "reactome": "R-DDI-73932", "name": "Resynthesis of excised residue by POLB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10580822" ], "products": [ "species_10580809", "species_113541" ], "modifiers": [ [ "species_10580822", "catalyst" ] ], "additional_components": [ "Q1ZXF2", "DDB_G0284713", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713", "Q1ZXF2", "DDB_G0284713", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857" ] }, "reaction_10582808": { "compartment": "compartment_7660", "id": "reaction_10582808", "reactome": "R-DDI-110376", "name": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580807", "species_10580820" ], "products": [ "species_10580822" ], "modifiers": [], "additional_components": [ "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713", "Q1ZXF2", "DDB_G0284713", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857" ] }, "reaction_10582786": { "compartment": "compartment_7660", "id": "reaction_10582786", "reactome": "R-DDI-110349", "name": "Displacement of UNG glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582782", "species_10582688" ], "products": [ "species_10582682", "species_10582784" ], "modifiers": [], "additional_components": [ "DDB_G0277701", "P53766", "DDB_G0277877", "DDB_G0277877", "P51173", "DDB_G0277701" ] }, "reaction_10582788": { "compartment": "compartment_7660", "id": "reaction_10582788", "reactome": "R-DDI-110352", "name": "Displacement of NTHL1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582782", "species_10582704" ], "products": [ "species_10582675", "species_10582784" ], "modifiers": [], "additional_components": [ "DDB_G0277701", "Q86K43", "DDB_G0277247", "DDB_G0277247", "P51173", "DDB_G0277701" ] }, "reaction_10582790": { "compartment": "compartment_7660", "id": "reaction_10582790", "reactome": "R-DDI-110354", "name": "Displacement of OGG1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582782", "species_10582739" ], "products": [ "species_10582733", "species_10582784" ], "modifiers": [], "additional_components": [ "DDB_G0277701", "Q54CZ3", "DDB_G0292618", "DDB_G0292618", "P51173", "DDB_G0277701" ] }, "reaction_10582792": { "compartment": "compartment_7660", "id": "reaction_10582792", "reactome": "R-DDI-110355", "name": "Displacement of MUTYH glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582782", "species_10582760" ], "products": [ "species_10582754", "species_10582784" ], "modifiers": [], "additional_components": [ "DDB_G0277701", "Q1ZXP7", "DDB_G0270764", "DDB_G0270764", "P51173", "DDB_G0277701" ] }, "reaction_10606194": { "compartment": "compartment_7660", "id": "reaction_10606194", "reactome": "R-DDI-5649734", "name": "LIG3 ligates NEIL1,NEIL2-generated single strand break", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606186" ], "products": [ "species_10606191" ], "modifiers": [ [ "species_10606186", "catalyst" ] ], "additional_components": [ "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713" ] }, "reaction_10606184": { "compartment": "compartment_7660", "id": "reaction_10606184", "reactome": "R-DDI-5649705", "name": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10606179" ], "products": [ "species_113550", "species_10606181" ], "modifiers": [ [ "species_10606179", "catalyst" ] ], "additional_components": [ "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713" ] }, "reaction_10606189": { "compartment": "compartment_7660", "id": "reaction_10606189", "reactome": "R-DDI-5649723", "name": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10606181" ], "products": [ "species_10606186", "species_113541" ], "modifiers": [ [ "species_10606181", "catalyst" ] ], "additional_components": [ "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713" ] }, "reaction_10606225": { "compartment": "compartment_7660", "id": "reaction_10606225", "reactome": "R-DDI-5649854", "name": "Recruitment of POLB to oxidatively damaged AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582815", "species_10580793" ], "products": [ "species_10582817" ], "modifiers": [], "additional_components": [ "P51173", "DDB_G0277701", "DDB_G0284713", "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701" ] }, "reaction_10606227": { "compartment": "compartment_7660", "id": "reaction_10606227", "reactome": "R-DDI-5649856", "name": "Oxidative damage to the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582796" ], "products": [ "species_10582815" ], "modifiers": [], "additional_components": [ "P51173", "DDB_G0277701", "P51173", "DDB_G0277701" ] }, "reaction_10606288": { "compartment": "compartment_7660", "id": "reaction_10606288", "reactome": "R-DDI-5651739", "name": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606281" ], "products": [ "species_10606286", "species_10606279" ], "modifiers": [], "additional_components": [ "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820", "Q1ZXF2", "DDB_G0284713", "Q54NU0", "DDB_G0284987", "Q1ZXF2", "DDB_G0284713", "Q54NU0", "DDB_G0284987", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820" ] }, "reaction_10606304": { "compartment": "compartment_7660", "id": "reaction_10606304", "reactome": "R-DDI-5651828", "name": "PARG dePARylates PARP1,PARP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10606279" ], "products": [ "species_5651834", "species_10606233" ], "modifiers": [ [ "species_10606240", "catalyst" ] ], "additional_components": [ "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "DDB_G0277943" ] }, "reaction_10606242": { "compartment": "compartment_7660", "id": "reaction_10606242", "reactome": "R-DDI-5649873", "name": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577480", "species_10606233", "species_10582821" ], "products": [ "species_10582782", "species_10606235" ], "modifiers": [ [ "species_10606240", "catalyst" ] ], "additional_components": [ "DDB_G0284987", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701", "DDB_G0277701", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q1ZXF2", "DDB_G0284713", "Q54NU0", "DDB_G0284987", "DDB_G0277943" ] }, "reaction_10606296": { "compartment": "compartment_7660", "id": "reaction_10606296", "reactome": "R-DDI-5651773", "name": "LIG1 binds POLB at long-patch BER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606292", "species_10577488" ], "products": [ "species_10606294" ], "modifiers": [], "additional_components": [ "Q1ZXF2", "DDB_G0284713", "DDB_G0274493", "Q869E1", "DDB_G0274493", "Q1ZXF2", "DDB_G0284713" ] }, "reaction_10606250": { "compartment": "compartment_7660", "id": "reaction_10606250", "reactome": "R-DDI-5649883", "name": "POLB-mediated DNA strand displacement synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10606235" ], "products": [ "species_10606247", "species_113541" ], "modifiers": [ [ "species_10606235", "catalyst" ] ], "additional_components": [ "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q1ZXF2", "DDB_G0284713", "Q54NU0", "DDB_G0284987", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q1ZXF2", "DDB_G0284713", "Q54NU0", "DDB_G0284987", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q1ZXF2", "DDB_G0284713", "Q54NU0", "DDB_G0284987" ] }, "reaction_10606301": { "compartment": "compartment_7660", "id": "reaction_10606301", "reactome": "R-DDI-5651789", "name": "LIG1 bound to POLB ligates SSB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606294" ], "products": [ "species_10606298" ], "modifiers": [ [ "species_10606294", "catalyst" ] ], "additional_components": [ "Q869E1", "DDB_G0274493", "Q1ZXF2", "DDB_G0284713", "Q869E1", "DDB_G0274493", "Q1ZXF2", "DDB_G0284713", "Q869E1", "DDB_G0274493", "Q1ZXF2", "DDB_G0284713" ] }, "reaction_10606284": { "compartment": "compartment_7660", "id": "reaction_10606284", "reactome": "R-DDI-5651723", "name": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606247", "species_427523" ], "products": [ "species_427497", "species_10606281" ], "modifiers": [ [ "species_10606247", "catalyst" ] ], "additional_components": [ "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q1ZXF2", "DDB_G0284713", "Q54NU0", "DDB_G0284987", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820", "Q1ZXF2", "DDB_G0284713", "Q54NU0", "DDB_G0284987", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q1ZXF2", "DDB_G0284713", "Q54NU0", "DDB_G0284987" ] }, "reaction_10582824": { "compartment": "compartment_7660", "id": "reaction_10582824", "reactome": "R-DDI-111253", "name": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10582817" ], "products": [ "species_10582821", "species_113541" ], "modifiers": [ [ "species_10582817", "catalyst" ] ], "additional_components": [ "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701", "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701", "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701" ] }, "reaction_10582799": { "compartment": "compartment_7660", "id": "reaction_10582799", "reactome": "R-DDI-110359", "name": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582784" ], "products": [ "species_10582796" ], "modifiers": [ [ "species_10582784", "catalyst" ] ], "additional_components": [ "P51173", "DDB_G0277701", "P51173", "DDB_G0277701", "P51173", "DDB_G0277701" ] }, "reaction_10626280": { "compartment": "compartment_876", "id": "reaction_10626280", "reactome": "R-DDI-9634834", "name": "ACHEIs bind ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9634838", "species_10589588" ], "products": [ "species_10589591" ], "modifiers": [], "additional_components": [ "Q54ET7", "DDB_G0291344", "Q86L18", "DDB_G0291344", "P18142", "DDB_G0283085", "Q54N21", "DDB_G0291344", "Q54WD8", "DDB_G0291344", "P21837", "DDB_G0285419", "Q54ET7", "DDB_G0291344", "Q86L18", "DDB_G0291344", "P18142", "DDB_G0283085", "Q54N21", "DDB_G0291344", "Q54WD8", "DDB_G0291344", "P21837", "DDB_G0285419" ] }, "reaction_10588771": { "compartment": "compartment_70101", "id": "reaction_10588771", "reactome": "R-DDI-210444", "name": "L-Glutamate loading of synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_10588768" ], "products": [ "species_10588746" ], "modifiers": [ [ "species_10588768", "catalyst" ] ], "additional_components": [ "Q54W37", "DDB_G0280761", "Q54UX4", "DDB_G0280761", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q1ZXE7", "DDB_G0286169", "P20790", "DDB_G0280043", "Q54RY4", "DDB_G0282899", "P20791", "DDB_G0276399", "Q54W37", "DDB_G0280761", "Q54UX4", "DDB_G0280761", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q1ZXE7", "DDB_G0286169", "P20790", "DDB_G0280043", "Q54RY4", "DDB_G0282899", "P20791", "DDB_G0276399", "species_113552", "Q54W37", "DDB_G0280761", "Q54UX4", "DDB_G0280761", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q1ZXE7", "DDB_G0286169", "P20790", "DDB_G0280043", "Q54RY4", "DDB_G0282899", "P20791", "DDB_G0276399" ] }, "reaction_10594460": { "compartment": "compartment_5460", "id": "reaction_10594460", "reactome": "R-DDI-916855", "name": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_916850", "species_113594" ], "products": [ "species_880046", "species_113552" ], "modifiers": [ [ "species_10594457", "catalyst" ] ], "additional_components": [ "Q55FI1", "DDB_G0268104", "CHEBI:33739" ] }, "reaction_10589611": { "compartment": "compartment_70101", "id": "reaction_10589611", "reactome": "R-DDI-374909", "name": "Metabolism of Noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209789", "species_29356", "species_29368" ], "products": [ "species_5279533", "species_29382", "species_29408" ], "modifiers": [ [ "species_10583604", "catalyst" ] ], "additional_components": [ "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10625621": { "compartment": "compartment_7660", "id": "reaction_10625621", "reactome": "R-DDI-9029434", "name": "p-S363,S380,T573 RS6K translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625593" ], "products": [ "species_10625619" ], "modifiers": [], "additional_components": [ "P34102", "DDB_G0286125", "Q8MYF1", "DDB_G0277449", "Q8MYF1", "DDB_G0277449", "P34102", "DDB_G0286125" ] }, "reaction_10613600": { "compartment": "compartment_876", "id": "reaction_10613600", "reactome": "R-DDI-6797630", "name": "LRPP4(LRPP1-3,5) hydrolyse LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_417891" ], "products": [ "species_109277", "species_6797635" ], "modifiers": [ [ "species_10613597", "catalyst" ] ], "additional_components": [ "Q54PR7", "DDB_G0284367", "Q86AF0", "DDB_G0284367", "Q8MXL9", "DDB_G0284367" ] }, "reaction_10590801": { "compartment": "compartment_70101", "id": "reaction_10590801", "reactome": "R-DDI-418553", "name": "cAMP degradation by Phosphodiesterases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10590798", "catalyst" ] ], "additional_components": [ "B0G0Y8", "DDB_G0268634", "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121" ] }, "reaction_10627473": { "compartment": "compartment_70101", "id": "reaction_10627473", "reactome": "R-DDI-9708261", "name": "PDE4A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10583084", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121" ] }, "reaction_10626265": { "compartment": "compartment_70101", "id": "reaction_10626265", "reactome": "R-DDI-9629675", "name": "PDE3A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10626262", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121" ] }, "reaction_10627406": { "compartment": "compartment_70101", "id": "reaction_10627406", "reactome": "R-DDI-9705507", "name": "PDE3B hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10627403", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121" ] }, "reaction_10590562": { "compartment": "compartment_876", "id": "reaction_10590562", "reactome": "R-DDI-392064", "name": "G alpha (z) inhibits adenylate cyclase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590558", "species_10583022" ], "products": [ "species_10590560" ], "modifiers": [], "additional_components": [ "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545" ] }, "reaction_10624233": { "compartment": "compartment_876", "id": "reaction_10624233", "reactome": "R-DDI-8981892", "name": "Active G alpha (z) binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590558", "species_10624229" ], "products": [ "species_10624231" ], "modifiers": [], "additional_components": [ "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "Q55E55", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q55E55", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q54M81", "DDB_G0286817", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438" ] }, "reaction_10624313": { "compartment": "compartment_876", "id": "reaction_10624313", "reactome": "R-DDI-8982021", "name": "G alpha (z) in G alpha (z):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624231" ], "products": [ "species_10624301", "species_29372" ], "modifiers": [ [ "species_10624231", "catalyst" ] ], "additional_components": [ "Q55E55", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q54M81", "DDB_G0286817", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "Q55E55", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q54M81", "DDB_G0286817", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29420", "Q55E55", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q54M81", "DDB_G0286817", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438" ] }, "reaction_10624303": { "compartment": "compartment_876", "id": "reaction_10624303", "reactome": "R-DDI-8982018", "name": "G alpha (z):RGS complex dissociates to give inactive G alpha (z)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624301" ], "products": [ "species_10624229", "species_10594134" ], "modifiers": [], "additional_components": [ "Q55E55", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q54M81", "DDB_G0286817", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29420", "Q55E55", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q54M81", "DDB_G0286817", "species_29420", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343" ] }, "reaction_10590810": { "compartment": "compartment_876", "id": "reaction_10590810", "reactome": "R-DDI-418574", "name": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590657" ], "products": [ "species_10590807" ], "modifiers": [ [ "species_10590657", "catalyst" ] ], "additional_components": [ "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29420", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438" ] }, "reaction_10625832": { "compartment": "compartment_70101", "id": "reaction_10625832", "reactome": "R-DDI-9603279", "name": "PIP3 recruits PDK1 and AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10587607", "species_10590487" ], "products": [ "species_10625830" ], "modifiers": [], "additional_components": [ "DDB_G0281471", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "Q54TW2", "DDB_G0281471", "species_179838", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795" ] }, "reaction_10590605": { "compartment": "compartment_70101", "id": "reaction_10590605", "reactome": "R-DDI-392300", "name": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10590602", "catalyst" ] ], "additional_components": [ "Q54DK0", "DDB_G0292252", "P54675", "DDB_G0275011", "P54673", "DDB_G0278727", "Q54S78", "DDB_G0282625", "Q55FX5", "DDB_G0282625", "P54674", "DDB_G0283081", "P36408", "DDB_G0277143" ] }, "reaction_10602042": { "compartment": "compartment_70101", "id": "reaction_10602042", "reactome": "R-DDI-3134962", "name": "DHX36 binds DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602038", "species_3134861" ], "products": [ "species_10602040" ], "modifiers": [], "additional_components": [ "DDB_G0275313", "Q869Z1", "DDB_G0275313" ] }, "reaction_10602073": { "compartment": "compartment_70101", "id": "reaction_10602073", "reactome": "R-DDI-3204303", "name": "MRE11 binds cytosolic DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_874088", "species_10602069" ], "products": [ "species_10602071" ], "modifiers": [], "additional_components": [ "DDB_G0293546", "Q54BN2", "DDB_G0293546", "species_874088" ] }, "reaction_10624938": { "compartment": "compartment_70101", "id": "reaction_10624938", "reactome": "R-DDI-9013869", "name": "DDX41 binds bacterial c-di-AMP, c-di-GMP ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8982080", "species_10602033" ], "products": [ "species_10624936" ], "modifiers": [], "additional_components": [ "CHEBI:49537", "CHEBI:47037", "DDB_G0287361", "Q54KG1", "DDB_G0287361", "CHEBI:49537", "CHEBI:47037" ] }, "reaction_10605089": { "compartment": "compartment_263163", "id": "reaction_10605089", "reactome": "R-DDI-5333658", "name": "CLAT:AP1:CLVS bind PI(3,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5334668", "species_10605085" ], "products": [ "species_10605087" ], "modifiers": [], "additional_components": [ "P25870", "DDB_G0277221", "Q54X82", "DDB_G0279141", "Q8I8U2", "DDB_G0281957", "Q54HS9", "DDB_G0289247", "Q54WW3", "DDB_G0279359", "B0G185", "DDB_G0295711", "P25870", "DDB_G0277221", "Q54X82", "DDB_G0279141", "Q8I8U2", "DDB_G0281957", "Q54HS9", "DDB_G0289247", "Q54WW3", "DDB_G0279359", "B0G185", "DDB_G0295711", "species_1806205" ] }, "reaction_10604872": { "compartment": "compartment_171907", "id": "reaction_10604872", "reactome": "R-DDI-5229111", "name": "AP4 transports APP from trans-Golgi network to endosome lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604855" ], "products": [ "species_10604869" ], "modifiers": [ [ "species_10604855", "catalyst" ] ], "additional_components": [ "Q54VE0", "DDB_G0280427", "Q9GPF0", "DDB_G0276945", "Q54NZ4", "DDB_G0284905", "Q54R84", "DDB_G0283319", "Q9GPF0", "DDB_G0276945", "Q54NZ4", "DDB_G0284905", "Q54R84", "DDB_G0283319", "Q54VE0", "DDB_G0280427", "Q54VE0", "DDB_G0280427", "Q9GPF0", "DDB_G0276945", "Q54NZ4", "DDB_G0284905", "Q54R84", "DDB_G0283319" ] }, "reaction_10592299": { "compartment": "compartment_70101", "id": "reaction_10592299", "reactome": "R-DDI-432706", "name": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10591135", "species_10591129", "species_10591141", "species_10592293" ], "products": [ "species_10589294", "species_29372", "species_10592297" ], "modifiers": [], "additional_components": [ "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "O00909", "DDB_G0289173", "Q54Y34", "DDB_G0292332", "Q1ZXA5", "DDB_G0292332", "Q54YV7", "DDB_G0278057", "Q54HK2", "DDB_G0289435", "Q55AR1", "DDB_G0271792", "Q54JJ3", "DDB_G0288015", "Q54SH9", "DDB_G0282457", "Q54V41", "DDB_G0280633", "Q54V47", "DDB_G0280621", "Q54VB0", "DDB_G0280479", "species_29438", "Q54HS9", "DDB_G0289247", "Q54WW3", "DDB_G0279359", "B0G185", "DDB_G0295711", "Q8I8U2", "DDB_G0281957", "Q54X82", "DDB_G0279141", "species_29420", "Q54V41", "DDB_G0280633", "Q54Y34", "DDB_G0292332", "Q54HK2", "DDB_G0289435", "Q54YV7", "DDB_G0278057", "Q54JJ3", "DDB_G0288015", "Q54V47", "DDB_G0280621", "O00909", "DDB_G0289173", "Q54VB0", "DDB_G0280479", "Q55AR1", "DDB_G0271792", "Q1ZXA5", "DDB_G0292332", "Q54SH9", "DDB_G0282457", "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "Q54HS9", "DDB_G0289247", "Q54WW3", "DDB_G0279359", "B0G185", "DDB_G0295711", "Q8I8U2", "DDB_G0281957", "Q54X82", "DDB_G0279141", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131" ] }, "reaction_10592302": { "compartment": "compartment_70101", "id": "reaction_10592302", "reactome": "R-DDI-432707", "name": "trans-Golgi Network Lysosomal Vesicle Scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10592297" ], "products": [ "species_10591135", "species_29372", "species_29420", "species_10591141", "species_10592225" ], "modifiers": [ [ "species_10592297", "catalyst" ] ], "additional_components": [ "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "Q54HS9", "DDB_G0289247", "Q54WW3", "DDB_G0279359", "B0G185", "DDB_G0295711", "Q8I8U2", "DDB_G0281957", "Q54X82", "DDB_G0279141", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "Q54X82", "DDB_G0279141", "Q8I8U2", "DDB_G0281957", "Q54HS9", "DDB_G0289247", "B0G185", "DDB_G0295711", "Q54WW3", "DDB_G0279359", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "Q54HS9", "DDB_G0289247", "Q54WW3", "DDB_G0279359", "B0G185", "DDB_G0295711", "Q8I8U2", "DDB_G0281957", "Q54X82", "DDB_G0279141", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131" ] }, "reaction_10589739": { "compartment": "compartment_70101", "id": "reaction_10589739", "reactome": "R-DDI-376357", "name": "Vamp7 associated Lysosome to Plasma membrane transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589710", "species_10589716", "species_10589728" ], "products": [ "species_10589710", "species_10589734", "species_10589716" ], "modifiers": [ [ "species_10589736", "catalyst" ] ], "additional_components": [ "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556", "Q54NW7", "DDB_G0284951", "Q86AQ7", "DDB_G0277173", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54NW7", "DDB_G0284951", "Q86AQ7", "DDB_G0277173", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556", "Q54NW7", "DDB_G0284951", "Q86AQ7", "DDB_G0277173", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590" ] }, "reaction_10589773": { "compartment": "compartment_876", "id": "reaction_10589773", "reactome": "R-DDI-376369", "name": "Vamp2 associated secretory vesicle to plasma membrane transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589710", "species_10589716", "species_10589762" ], "products": [ "species_10589710", "species_10589768", "species_10589716" ], "modifiers": [ [ "species_10589770", "catalyst" ] ], "additional_components": [ "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590" ] }, "reaction_10589340": { "compartment": "compartment_70101", "id": "reaction_10589340", "reactome": "R-DDI-350769", "name": "trans-Golgi Network Coat Activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589294", "species_29438" ], "products": [ "species_29420", "species_10589320" ], "modifiers": [ [ "species_10589337", "catalyst" ] ], "additional_components": [ "species_29420", "Q54V41", "DDB_G0280633", "Q54Y34", "DDB_G0292332", "Q54HK2", "DDB_G0289435", "Q54YV7", "DDB_G0278057", "Q54JJ3", "DDB_G0288015", "Q54V47", "DDB_G0280621", "O00909", "DDB_G0289173", "Q54VB0", "DDB_G0280479", "Q55AR1", "DDB_G0271792", "Q1ZXA5", "DDB_G0292332", "Q54SH9", "DDB_G0282457", "O00909", "DDB_G0289173", "Q54Y34", "DDB_G0292332", "Q1ZXA5", "DDB_G0292332", "Q54YV7", "DDB_G0278057", "Q54HK2", "DDB_G0289435", "Q55AR1", "DDB_G0271792", "Q54JJ3", "DDB_G0288015", "Q54SH9", "DDB_G0282457", "Q54V41", "DDB_G0280633", "Q54V47", "DDB_G0280621", "Q54VB0", "DDB_G0280479", "species_29438", "Q54X30", "DDB_G0290771", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771" ] }, "reaction_10589756": { "compartment": "compartment_70101", "id": "reaction_10589756", "reactome": "R-DDI-376364", "name": "Vamp8 associated secretory vesicle to plasma membrane transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589710", "species_10589716", "species_10589745" ], "products": [ "species_10589710", "species_10589751", "species_10589716" ], "modifiers": [ [ "species_10589753", "catalyst" ] ], "additional_components": [ "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590" ] }, "reaction_10586000": { "compartment": "compartment_984", "id": "reaction_10586000", "reactome": "R-DDI-189102", "name": "maltose + H2O => 2 D-glucose (maltase-glucoamylase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_188986" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10585997", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10586372": { "compartment": "compartment_984", "id": "reaction_10586372", "reactome": "R-DDI-191101", "name": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_191103" ], "products": [ "species_188986", "species_70115" ], "modifiers": [ [ "species_10585987", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10585990": { "compartment": "compartment_984", "id": "reaction_10585990", "reactome": "R-DDI-189053", "name": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_189108" ], "products": [ "species_191103", "species_188986", "species_70115" ], "modifiers": [ [ "species_10585987", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10586374": { "compartment": "compartment_984", "id": "reaction_10586374", "reactome": "R-DDI-191108", "name": "maltose + H2O => 2 D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_188986" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10585987", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10585993": { "compartment": "compartment_984", "id": "reaction_10585993", "reactome": "R-DDI-189069", "name": "sucrose + H2O => glucose + fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_188980" ], "products": [ "species_189049", "species_70115" ], "modifiers": [ [ "species_10585987", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10586376": { "compartment": "compartment_984", "id": "reaction_10586376", "reactome": "R-DDI-191116", "name": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_191103" ], "products": [ "species_188986", "species_70115" ], "modifiers": [ [ "species_10585997", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10606570": { "compartment": "compartment_984", "id": "reaction_10606570", "reactome": "R-DDI-5659861", "name": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_5659875" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10585987", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10623860": { "compartment": "compartment_7660", "id": "reaction_10623860", "reactome": "R-DDI-8953398", "name": "PIR oxygenates quercetin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8953397", "species_113685" ], "products": [ "species_8953399", "species_8953383" ], "modifiers": [ [ "species_10623857", "catalyst" ] ], "additional_components": [ "DDB_G0273413" ] }, "reaction_10600033": { "compartment": "compartment_876", "id": "reaction_10600033", "reactome": "R-DDI-2029471", "name": "Hydrolysis of PC to PA by PLD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429802", "species_29356" ], "products": [ "species_264618", "species_1602448" ], "modifiers": [ [ "species_10600030", "catalyst" ] ], "additional_components": [ "Q54Z25", "DDB_G0277949" ] }, "reaction_10600008": { "compartment": "compartment_876", "id": "reaction_10600008", "reactome": "R-DDI-2029468", "name": "Conversion of PA into DAG by PAP-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1602448" ], "products": [ "species_29372", "species_112275" ], "modifiers": [ [ "species_10600005", "catalyst" ] ], "additional_components": [ "Q54PR7", "DDB_G0284367", "Q86AF0", "DDB_G0284367", "Q8MXL9", "DDB_G0284367" ] }, "reaction_10620323": { "compartment": "compartment_876", "id": "reaction_10620323", "reactome": "R-DDI-8868648", "name": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10620318" ], "products": [ "species_29372", "species_10620320" ], "modifiers": [ [ "species_10620318", "catalyst" ] ], "additional_components": [ "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "species_179856", "Q54U74", "DDB_G0281235", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q555L8", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q75JD4", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "B0G198", "DDB_G0295683", "Q1ZXE9", "DDB_G0285703", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29438", "Q54U74", "DDB_G0281235", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q54KI4", "DDB_G0287325", "species_1806180", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "species_113592", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q1ZXE9", "DDB_G0285703", "B0G198", "DDB_G0295683", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q55AN3", "DDB_G0274805", "Q555L8", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "C7FZZ0", "DDB_G0274805", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29438", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "species_179856", "Q54U74", "DDB_G0281235", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q555L8", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q75JD4", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "B0G198", "DDB_G0295683", "Q1ZXE9", "DDB_G0285703", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29438" ] }, "reaction_10619620": { "compartment": "compartment_876", "id": "reaction_10619620", "reactome": "R-DDI-8856808", "name": "Recruitment of AP-2 complex and clathrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10591129", "species_10619610", "species_10619527", "species_10619616", "species_10619539" ], "products": [ "species_10619618" ], "modifiers": [], "additional_components": [ "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q54KI4", "DDB_G0287325", "species_179856", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54U74", "DDB_G0281235", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q54U74", "DDB_G0281235", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q54KI4", "DDB_G0287325", "species_179856" ] }, "reaction_10620325": { "compartment": "compartment_876", "id": "reaction_10620325", "reactome": "R-DDI-8868651", "name": "Endophilins recruit synaptojanins to the clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620314", "species_10598818" ], "products": [ "species_10620318" ], "modifiers": [], "additional_components": [ "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "species_179856", "Q54U74", "DDB_G0281235", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q555L8", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q75JD4", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "B0G198", "DDB_G0295683", "Q1ZXE9", "DDB_G0285703", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29438", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "species_179856", "Q54U74", "DDB_G0281235", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q555L8", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q75JD4", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "B0G198", "DDB_G0295683", "Q1ZXE9", "DDB_G0285703", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29438" ] }, "reaction_10620267": { "compartment": "compartment_876", "id": "reaction_10620267", "reactome": "R-DDI-8868066", "name": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10598590", "catalyst" ] ], "additional_components": [ "Q54DL4", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635", "Q86D86", "DDB_G0283615" ] }, "reaction_10619662": { "compartment": "compartment_876", "id": "reaction_10619662", "reactome": "R-DDI-8862280", "name": "FCHo proteins bind nascent clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619596", "species_10619608", "species_10588585", "species_10619588", "species_10619590", "species_10619586" ], "products": [ "species_10619610" ], "modifiers": [], "additional_components": [ "species_179856", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q555L8", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q75JD4", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "DDB_G0287325", "DDB_G0287325", "DDB_G0287325", "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q54KI4", "DDB_G0287325", "species_179856", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403" ] }, "reaction_10619630": { "compartment": "compartment_876", "id": "reaction_10619630", "reactome": "R-DDI-8856813", "name": "AAK1 phosphorylates AP-2 mu subunit at T156", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10619618" ], "products": [ "species_29370", "species_10619627" ], "modifiers": [ [ "species_10619618", "catalyst" ] ], "additional_components": [ "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q54U74", "DDB_G0281235", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q54KI4", "DDB_G0287325", "species_179856", "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q54U74", "DDB_G0281235", "species_179856", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q54U74", "DDB_G0281235", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q54KI4", "DDB_G0287325", "species_179856" ] }, "reaction_10621967": { "compartment": "compartment_24339", "id": "reaction_10621967", "reactome": "R-DDI-8871194", "name": "RAB5 and GAPVD1 bind AP-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10621961", "species_10620427" ], "products": [ "species_10621963" ], "modifiers": [], "additional_components": [ "Q86JP3", "DDB_G0271984", "species_29420", "Q54HF9", "DDB_G0291115", "Q54W41", "DDB_G0291115", "Q55AA6", "DDB_G0291115", "Q54NU1", "DDB_G0291115", "Q55AI4", "DDB_G0291115", "Q54VS5", "DDB_G0291115", "Q54F48", "DDB_G0291115", "Q54U74", "DDB_G0281235", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q54KI4", "DDB_G0287325", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29420", "Q54UC8", "DDB_G0281155", "Q55FQ9", "DDB_G0267440", "Q54P67", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54JR2", "DDB_G0287691", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54Y50", "DDB_G0278685", "species_1806180", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q8T867", "DDB_G0276447", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "species_113592", "Q1ZXE9", "DDB_G0285703", "B0G198", "DDB_G0295683", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q55AN3", "DDB_G0274805", "Q555L8", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "C7FZZ0", "DDB_G0274805", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q54U74", "DDB_G0281235", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q54KI4", "DDB_G0287325", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29420", "Q54UC8", "DDB_G0281155", "Q55FQ9", "DDB_G0267440", "Q54P67", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54JR2", "DDB_G0287691", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54Y50", "DDB_G0278685", "species_1806180", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q8T867", "DDB_G0276447", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "species_113592", "Q1ZXE9", "DDB_G0285703", "B0G198", "DDB_G0295683", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q55AN3", "DDB_G0274805", "Q555L8", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "C7FZZ0", "DDB_G0274805", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q86JP3", "DDB_G0271984", "Q54HF9", "DDB_G0291115", "Q54W41", "DDB_G0291115", "Q55AA6", "DDB_G0291115", "Q54NU1", "DDB_G0291115", "Q55AI4", "DDB_G0291115", "Q54VS5", "DDB_G0291115", "Q54F48", "DDB_G0291115" ] }, "reaction_10619890": { "compartment": "compartment_70101", "id": "reaction_10619890", "reactome": "R-DDI-8866275", "name": "UBQLNs bind UIM-containing adaptor proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619886", "species_10619878" ], "products": [ "species_10619888" ], "modifiers": [], "additional_components": [ "Q54KI4", "DDB_G0287325", "Q54EH1", "DDB_G0291512", "DDB_G0267452", "Q9NIF3", "DDB_G0267452", "Q54KI4", "DDB_G0287325", "Q54EH1", "DDB_G0291512" ] }, "reaction_10619715": { "compartment": "compartment_70101", "id": "reaction_10619715", "reactome": "R-DDI-8863723", "name": "COP9 and TOR1 deneddylate STON2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619706" ], "products": [ "species_10619710", "species_10619704", "species_10611062", "species_10619684" ], "modifiers": [ [ "species_10619706", "catalyst" ] ], "additional_components": [ "Q55FE2", "DDB_G0268156", "Q75K24", "DDB_G0275471", "Q54C92", "DDB_G0293180", "Q54QX3", "DDB_G0283587", "Q55BD5", "DDB_G0271282", "Q54E53", "DDB_G0291848", "Q54HL6", "DDB_G0289361", "Q54PF3", "DDB_G0284597", "Q54B82", "DDB_G0293844", "P54672", "DDB_G0277139", "DDB_G0277139", "Q75K24", "DDB_G0275471", "Q54C92", "DDB_G0293180", "Q54QX3", "DDB_G0283587", "Q55BD5", "DDB_G0271282", "Q54E53", "DDB_G0291848", "Q54HL6", "DDB_G0289361", "Q54PF3", "DDB_G0284597", "Q54B82", "DDB_G0293844", "DDB_G0278711", "Q55FE2", "DDB_G0268156", "Q55FE2", "DDB_G0268156", "Q75K24", "DDB_G0275471", "Q54C92", "DDB_G0293180", "Q54QX3", "DDB_G0283587", "Q55BD5", "DDB_G0271282", "Q54E53", "DDB_G0291848", "Q54HL6", "DDB_G0289361", "Q54PF3", "DDB_G0284597", "Q54B82", "DDB_G0293844", "P54672", "DDB_G0277139" ] }, "reaction_10627348": { "compartment": "compartment_70101", "id": "reaction_10627348", "reactome": "R-DDI-9681616", "name": "AP2 binds chlorpromazine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9648300", "species_10619527" ], "products": [ "species_10619943" ], "modifiers": [], "additional_components": [ "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439" ] }, "reaction_10619717": { "compartment": "compartment_70101", "id": "reaction_10619717", "reactome": "R-DDI-8863727", "name": "STON2 is neddylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619710", "species_10611062" ], "products": [ "species_10619672" ], "modifiers": [], "additional_components": [ "DDB_G0277139", "DDB_G0278711", "DDB_G0277139" ] }, "reaction_10619945": { "compartment": "compartment_876", "id": "reaction_10619945", "reactome": "R-DDI-8866277", "name": "AP-2 directly binds some endocytic cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619527", "species_10619939" ], "products": [ "species_10619941" ], "modifiers": [ [ "species_10619943", "inhibitor" ] ], "additional_components": [ "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439" ] }, "reaction_10620089": { "compartment": "compartment_876", "id": "reaction_10620089", "reactome": "R-DDI-8867613", "name": "PICALM binds R-SNAREs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620079", "species_10620085" ], "products": [ "species_10620087" ], "modifiers": [], "additional_components": [ "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54Y50", "DDB_G0278685", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061" ] }, "reaction_10619708": { "compartment": "compartment_70101", "id": "reaction_10619708", "reactome": "R-DDI-8863721", "name": "NEDD8-STON binds TOR1 hexamer and COP9 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619704", "species_10619672", "species_10619684" ], "products": [ "species_10619706" ], "modifiers": [], "additional_components": [ "Q75K24", "DDB_G0275471", "Q54C92", "DDB_G0293180", "Q54QX3", "DDB_G0283587", "Q55BD5", "DDB_G0271282", "Q54E53", "DDB_G0291848", "Q54HL6", "DDB_G0289361", "Q54PF3", "DDB_G0284597", "Q54B82", "DDB_G0293844", "DDB_G0277139", "Q55FE2", "DDB_G0268156", "Q55FE2", "DDB_G0268156", "Q75K24", "DDB_G0275471", "Q54C92", "DDB_G0293180", "Q54QX3", "DDB_G0283587", "Q55BD5", "DDB_G0271282", "Q54E53", "DDB_G0291848", "Q54HL6", "DDB_G0289361", "Q54PF3", "DDB_G0284597", "Q54B82", "DDB_G0293844", "P54672", "DDB_G0277139" ] }, "reaction_10620237": { "compartment": "compartment_876", "id": "reaction_10620237", "reactome": "R-DDI-8867756", "name": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620157", "species_10619627" ], "products": [ "species_10620159" ], "modifiers": [], "additional_components": [ "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q54U74", "DDB_G0281235", "species_179856", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q54U74", "DDB_G0281235", "species_179856", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691" ] }, "reaction_10620269": { "compartment": "compartment_876", "id": "reaction_10620269", "reactome": "R-DDI-8868071", "name": "Clathrin recruits PIK3C2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620159", "species_10598852" ], "products": [ "species_10620161" ], "modifiers": [], "additional_components": [ "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q54U74", "DDB_G0281235", "species_179856", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q54S78", "DDB_G0282625", "Q55FX5", "DDB_G0282625", "P54673", "DDB_G0278727", "P54674", "DDB_G0283081", "P54675", "DDB_G0275011", "Q54S78", "DDB_G0282625", "Q55FX5", "DDB_G0282625", "P54673", "DDB_G0278727", "P54674", "DDB_G0283081", "P54675", "DDB_G0275011", "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q54U74", "DDB_G0281235", "species_179856", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691" ] }, "reaction_10621965": { "compartment": "compartment_24339", "id": "reaction_10621965", "reactome": "R-DDI-8871193", "name": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10621963" ], "products": [ "species_10620531", "species_10619539" ], "modifiers": [], "additional_components": [ "Q54U74", "DDB_G0281235", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q54KI4", "DDB_G0287325", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29420", "Q54UC8", "DDB_G0281155", "Q55FQ9", "DDB_G0267440", "Q54P67", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54JR2", "DDB_G0287691", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54Y50", "DDB_G0278685", "species_1806180", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q8T867", "DDB_G0276447", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "species_113592", "Q1ZXE9", "DDB_G0285703", "B0G198", "DDB_G0295683", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q55AN3", "DDB_G0274805", "Q555L8", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "C7FZZ0", "DDB_G0274805", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q86JP3", "DDB_G0271984", "Q54HF9", "DDB_G0291115", "Q54W41", "DDB_G0291115", "Q55AA6", "DDB_G0291115", "Q54NU1", "DDB_G0291115", "Q55AI4", "DDB_G0291115", "Q54VS5", "DDB_G0291115", "Q54F48", "DDB_G0291115", "Q54U74", "DDB_G0281235", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q54KI4", "DDB_G0287325", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29420", "Q54UC8", "DDB_G0281155", "Q55FQ9", "DDB_G0267440", "Q54P67", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54JR2", "DDB_G0287691", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54Y50", "DDB_G0278685", "species_1806180", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q8T867", "DDB_G0276447", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "species_113592", "Q1ZXE9", "DDB_G0285703", "B0G198", "DDB_G0295683", "Q55AN3", "DDB_G0274805", "Q555L8", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "C7FZZ0", "DDB_G0274805", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q86JP3", "DDB_G0271984", "species_29438", "Q54HF9", "DDB_G0291115", "Q54W41", "DDB_G0291115", "Q55AA6", "DDB_G0291115", "Q54NU1", "DDB_G0291115", "Q55AI4", "DDB_G0291115", "Q54VS5", "DDB_G0291115", "Q54F48", "DDB_G0291115", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111" ] }, "reaction_10620272": { "compartment": "compartment_876", "id": "reaction_10620272", "reactome": "R-DDI-8868072", "name": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10620161", "catalyst" ] ], "additional_components": [ "Q54S78", "DDB_G0282625", "Q55FX5", "DDB_G0282625", "P54673", "DDB_G0278727", "P54674", "DDB_G0283081", "P54675", "DDB_G0275011", "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q54U74", "DDB_G0281235", "species_179856", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691" ] }, "reaction_10620432": { "compartment": "compartment_24339", "id": "reaction_10620432", "reactome": "R-DDI-8868658", "name": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10620425" ], "products": [ "species_10620429", "species_29372", "species_10620427" ], "modifiers": [ [ "species_10620425", "catalyst" ] ], "additional_components": [ "Q54U74", "DDB_G0281235", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29420", "Q54KI4", "DDB_G0287325", "Q8T867", "DDB_G0276447", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "species_113592", "P36415", "DDB_G0269144", "Q55AN3", "DDB_G0274805", "Q555L8", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "C7FZZ0", "DDB_G0274805", "Q54UC8", "DDB_G0281155", "Q55FQ9", "DDB_G0267440", "Q54P67", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q54D31", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10591129", "species_10619527", "species_179856" ], "products": [ "species_10619596" ], "modifiers": [], "additional_components": [ "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "species_179856", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403" ] }, "reaction_10620438": { "compartment": "compartment_24339", "id": "reaction_10620438", "reactome": "R-DDI-8868659", "name": "Clathrin recruits auxilins to the clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"reaction_10620440": { "compartment": "compartment_24339", "id": "reaction_10620440", "reactome": "R-DDI-8868660", "name": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602861", "species_10620436" ], "products": [ "species_10620425" ], "modifiers": [], "additional_components": [ "species_113592", "P36415", "DDB_G0269144", "Q54U74", "DDB_G0281235", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29420", "Q54KI4", "DDB_G0287325", "Q8T867", "DDB_G0276447", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q55AN3", "DDB_G0274805", "Q555L8", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "C7FZZ0", "DDB_G0274805", "Q54UC8", "DDB_G0281155", "Q55FQ9", "DDB_G0267440", "Q54P67", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54JR2", "DDB_G0287691", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54Y50", "DDB_G0278685", "species_1806180", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "species_113592", "Q1ZXE9", "DDB_G0285703", "B0G198", "DDB_G0295683", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54U74", "DDB_G0281235", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29420", "Q54KI4", "DDB_G0287325", "Q8T867", "DDB_G0276447", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "species_113592", "P36415", "DDB_G0269144", "Q55AN3", "DDB_G0274805", "Q555L8", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "C7FZZ0", "DDB_G0274805", "Q54UC8", "DDB_G0281155", "Q55FQ9", "DDB_G0267440", "Q54P67", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54JR2", "DDB_G0287691", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54Y50", "DDB_G0278685", "species_1806180", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "Q1ZXE9", "DDB_G0285703", "B0G198", "DDB_G0295683", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403" ] }, "reaction_10620316": { "compartment": "compartment_876", "id": "reaction_10620316", "reactome": "R-DDI-8868236", "name": "BAR domain proteins recruit dynamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620312", "species_10620310" ], "products": [ "species_10620314" ], "modifiers": [], "additional_components": [ "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29438", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "species_179856", "Q54U74", "DDB_G0281235", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q555L8", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q75JD4", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "B0G198", "DDB_G0295683", "Q1ZXE9", "DDB_G0285703", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "species_179856", "Q54U74", "DDB_G0281235", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q555L8", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q75JD4", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "B0G198", "DDB_G0295683", "Q1ZXE9", "DDB_G0285703", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29438" ] }, "reaction_10601617": { "compartment": "compartment_70101", "id": "reaction_10601617", "reactome": "R-DDI-2872497", "name": "SLC17A3-2 transports cytosolic urate to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30034" ], "products": [ "species_429056" ], "modifiers": [ [ "species_10601614", "catalyst" ] ], "additional_components": [ "Q54UX4", "DDB_G0280761", "Q54W37", "DDB_G0280761" ] }, "reaction_10601536": { "compartment": "compartment_70101", "id": "reaction_10601536", "reactome": "R-DDI-2730692", "name": "CLCN4/5/6 exchange Cl- for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_2731008" ], "products": [ "species_74722", "species_352022" ], "modifiers": [ [ "species_10601533", "catalyst" ] ], "additional_components": [ "DDB_G0278639" ] }, "reaction_10627397": { "compartment": "compartment_70101", "id": "reaction_10627397", "reactome": "R-DDI-9701055", "name": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10627394", "catalyst" ], [ "species_10602358", "catalyst" ] ], "additional_components": [ "Q54J43", "DDB_G0288307", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417" ] }, "reaction_10602360": { "compartment": "compartment_70101", "id": "reaction_10602360", "reactome": "R-DDI-3295579", "name": "TRPs transport extracellular Ca2+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10602335", "catalyst" ], [ "species_10602358", "catalyst" ] ], "additional_components": [ "Q54EY0", "DDB_G0291275", "Q54J43", "DDB_G0288307", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417" ] }, "reaction_10601528": { "compartment": "compartment_70101", "id": "reaction_10601528", "reactome": "R-DDI-2684901", "name": "ANOs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10601525", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q54BH1", "DDB_G0293626", "Q55GA1", "DDB_G0293626" ] }, "reaction_10601608": { "compartment": "compartment_70101", "id": "reaction_10601608", "reactome": "R-DDI-2744228", "name": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10601605", "catalyst" ] ], "additional_components": [ "Q54C67", "DDB_G0293130", "Q54LQ4", "DDB_G0286491" ] }, "reaction_10601626": { "compartment": "compartment_70101", "id": "reaction_10601626", "reactome": "R-DDI-2872498", "name": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_83910" ], "products": [ "species_113551", "species_2892454" ], "modifiers": [ [ "species_10601623", "catalyst" ] ], "additional_components": [ "Q54UX4", "DDB_G0280761", "Q54W37", "DDB_G0280761" ] }, "reaction_10627086": { "compartment": "compartment_70101", "id": "reaction_10627086", "reactome": "R-DDI-9659568", "name": "ANO1 transports cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10601485", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q54BH1", "DDB_G0293626", "Q55GA1", "DDB_G0293626" ] }, "reaction_10592547": { "compartment": "compartment_876", "id": "reaction_10592547", "reactome": "R-DDI-444416", "name": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31633" ], "products": [ "species_140912" ], "modifiers": [ [ "species_10592544", "catalyst" ] ], "additional_components": [ "Q8I0L6", "DDB_G0280059", "Q9NIV0", "DDB_G0283389" ] }, "reaction_10592822": { "compartment": "compartment_876", "id": "reaction_10592822", "reactome": "R-DDI-446277", "name": "RhCG mediates ammonium efflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10592535", "catalyst" ] ], "additional_components": [ "Q8I0L6", "DDB_G0280059", "Q9NIV0", "DDB_G0283389" ] }, "reaction_10592552": { "compartment": "compartment_876", "id": "reaction_10592552", "reactome": "R-DDI-444419", "name": "RhBG mediates ammonium effflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10592549", "catalyst" ] ], "additional_components": [ "DDB_G0280059" ] }, "reaction_10592824": { "compartment": "compartment_876", "id": "reaction_10592824", "reactome": "R-DDI-446278", "name": "RhBG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10592549", "catalyst" ] ], "additional_components": [ "DDB_G0280059" ] }, "reaction_10592538": { "compartment": "compartment_876", "id": "reaction_10592538", "reactome": "R-DDI-444393", "name": "RhCG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10592535", "catalyst" ] ], "additional_components": [ "Q8I0L6", "DDB_G0280059", "Q9NIV0", "DDB_G0283389" ] }, "reaction_10592523": { "compartment": "compartment_876", "id": "reaction_10592523", "reactome": "R-DDI-444126", "name": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_432019" ], "products": [ "species_29514" ], "modifiers": [ [ "species_10592520", "catalyst" ] ], "additional_components": [ "Q86AP4", "DDB_G0277263" ] }, "reaction_10591788": { "compartment": "compartment_876", "id": "reaction_10591788", "reactome": "R-DDI-429101", "name": "HMIT co-transports myo-inositol with a proton", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_429130" ], "products": [ "species_70106", "species_426910" ], "modifiers": [ [ "species_10591785", "catalyst" ] ], "additional_components": [ "DDB_G0278261" ] }, "reaction_10592375": { "compartment": "compartment_172574", "id": "reaction_10592375", "reactome": "R-DDI-435171", "name": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_445829" ], "products": [ "species_445832", "species_1470067" ], "modifiers": [ [ "species_10592372", "catalyst" ] ], "additional_components": [ "species_29426", "species_71067", "species_266099", "species_29426", "species_266099", "species_71067", "DDB_G0276973" ] }, "reaction_10592422": { "compartment": "compartment_876", "id": "reaction_10592422", "reactome": "R-DDI-437300", "name": "SLC31A1 transports Cu2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_437295" ], "products": [ "species_209799" ], "modifiers": [ [ "species_10592419", "catalyst" ] ], "additional_components": [ "DDB_G0285545" ] }, "reaction_10624126": { "compartment": "compartment_70101", "id": "reaction_10624126", "reactome": "R-DDI-8959798", "name": "SLC30A10 transports Mn2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29418" ], "products": [ "species_266099" ], "modifiers": [ [ "species_10624123", "catalyst" ] ], "additional_components": [ "DDB_G0282067" ] }, "reaction_10592380": { "compartment": "compartment_876", "id": "reaction_10592380", "reactome": "R-DDI-435349", "name": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_435347" ], "products": [ "species_70106", "species_71067" ], "modifiers": [ [ "species_10592377", "catalyst" ] ], "additional_components": [ "DDB_G0276973" ] }, "reaction_10592367": { "compartment": "compartment_876", "id": "reaction_10592367", "reactome": "R-DDI-434650", "name": "MATEs mediate extrusion of xenobiotics", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_446589" ], "products": [ "species_70106", "species_446597" ], "modifiers": [ [ "species_10592364", "catalyst" ] ], "additional_components": [ "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:641", "CHEBI:6801", "CHEBI:16737", "CHEBI:8428", "CHEBI:42820", "CHEBI:16737", "CHEBI:641", "CHEBI:46020", "CHEBI:6801", "Q54YM8", "DDB_G0292132", "Q54DM2", "DDB_G0292132" ] }, "reaction_10594911": { "compartment": "compartment_70101", "id": "reaction_10594911", "reactome": "R-DDI-927789", "name": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594907", "species_10594881" ], "products": [ "species_10594909" ], "modifiers": [], "additional_components": [ "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q9BMX0", "DDB_G0288613", "Q54KR9", "DDB_G0287197", "Q55D17", "DDB_G0269814", "Q54BM2", "DDB_G0293558", "Q553R3", "DDB_G0275395", "Q7YZN9", "DDB_G0277919", "species_29420", "DDB_G0288923", "Q54I89", "DDB_G0288923", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q9BMX0", "DDB_G0288613", "Q54KR9", "DDB_G0287197", "Q55D17", "DDB_G0269814", "Q54BM2", "DDB_G0293558", "Q553R3", "DDB_G0275395", "Q7YZN9", "DDB_G0277919", "species_29420" ] }, "reaction_10594987": { "compartment": "compartment_70101", "id": "reaction_10594987", "reactome": "R-DDI-927889", "name": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10594982" ], "products": [ "species_29370", "species_10594984" ], "modifiers": [ [ "species_10594982", "catalyst" ] ], "additional_components": [ "Q54I89", "DDB_G0288923", "Q54R12", "DDB_G0283447", "Q75JP6", "DDB_G0272470", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q9BMX0", "DDB_G0288613", "Q54DH9", "DDB_G0292240", "Q54ME8", "DDB_G0286007", "Q55E21", "DDB_G0270866", "Q55D61", "DDB_G0269192", "Q54TQ1", "DDB_G0281623", "Q55A46", "DDB_G0272108", "Q7YZN9", "DDB_G0277919", "species_29420", "Q54KR9", "DDB_G0287197", "Q55D17", "DDB_G0269814", "Q54BM2", "DDB_G0293558", "Q553R3", "DDB_G0275395", "Q54I89", "DDB_G0288923", "Q54R12", "DDB_G0283447", "Q75JP6", "DDB_G0272470", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q9BMX0", "DDB_G0288613", "Q54DH9", "DDB_G0292240", "Q54ME8", "DDB_G0286007", "Q55E21", "DDB_G0270866", "Q55D61", "DDB_G0269192", "Q54TQ1", "DDB_G0281623", "Q55A46", "DDB_G0272108", "Q7YZN9", "DDB_G0277919", "species_29420", "Q54KR9", "DDB_G0287197", "Q55D17", "DDB_G0269814", "Q54BM2", "DDB_G0293558", "Q553R3", "DDB_G0275395", "Q54I89", "DDB_G0288923", "Q54R12", "DDB_G0283447", "Q75JP6", "DDB_G0272470", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q9BMX0", "DDB_G0288613", "Q54DH9", "DDB_G0292240", "Q54ME8", "DDB_G0286007", "Q55E21", "DDB_G0270866", "Q55D61", "DDB_G0269192", "Q54TQ1", "DDB_G0281623", "Q55A46", "DDB_G0272108", "Q7YZN9", "DDB_G0277919", "species_29420", "Q54KR9", "DDB_G0287197", "Q55D17", "DDB_G0269814", "Q54BM2", "DDB_G0293558", "Q553R3", "DDB_G0275395" ] }, "reaction_10582497": { "compartment": "compartment_7660", "id": "reaction_10582497", "reactome": "R-DDI-83790", "name": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582491", "species_10581800" ], "products": [ "species_10582495" ], "modifiers": [], "additional_components": [ "Q8T1F9", "DDB_G0275127", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54YB5", "DDB_G0278321", "Q54FU1", "DDB_G0290591", "Q54U85", "DDB_G0281215", "Q54R53", "DDB_G0283405", "P26355", "DDB_G0275617", "Q54U85", "DDB_G0281215", "Q54R53", "DDB_G0283405", "P26355", "DDB_G0275617", "Q8T1F9", "DDB_G0275127", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54YB5", "DDB_G0278321", "Q54FU1", "DDB_G0290591" ] }, "reaction_10582501": { "compartment": "compartment_7660", "id": "reaction_10582501", "reactome": "R-DDI-83805", "name": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582495", "species_10581897" ], "products": [ "species_10582499" ], "modifiers": [], "additional_components": [ "Q54U85", "DDB_G0281215", "Q54R53", "DDB_G0283405", "P26355", "DDB_G0275617", "Q8T1F9", "DDB_G0275127", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54YB5", "DDB_G0278321", "Q54FU1", "DDB_G0290591", "Q557J3", "DDB_G0273425", "Q54LP2", "DDB_G0286521", "Q54R66", "DDB_G0283365", "Q54IM0", "DDB_G0288665", "Q55FJ5", "DDB_G0268080", "Q86JM3", "DDB_G0272022", "Q54EH2", "DDB_G0291636", "Q54K02", "DDB_G0287707", "Q54SN4", "DDB_G0282339", "Q54FA8", "DDB_G0291037", "Q8T1V7", "DDB_G0277671", "Q86JI9", "DDB_G0271514", "Q55AB6", "DDB_G0272036", "Q86AQ5", "DDB_G0277199", "Q54IZ9", "DDB_G0288449", "Q54YW8", "DDB_G0278039", "Q557J3", "DDB_G0273425", "Q54LP2", "DDB_G0286521", "Q54R66", "DDB_G0283365", "Q54IM0", "DDB_G0288665", "Q55FJ5", "DDB_G0268080", "Q86JM3", "DDB_G0272022", "Q54EH2", "DDB_G0291636", "Q54K02", "DDB_G0287707", "Q54SN4", "DDB_G0282339", "Q54FA8", "DDB_G0291037", "Q8T1V7", "DDB_G0277671", "Q86JI9", "DDB_G0271514", "Q55AB6", "DDB_G0272036", "Q86AQ5", "DDB_G0277199", "Q54IZ9", "DDB_G0288449", "Q54YW8", "DDB_G0278039", "Q54U85", "DDB_G0281215", "Q54R53", "DDB_G0283405", "P26355", "DDB_G0275617", "Q8T1F9", "DDB_G0275127", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54YB5", "DDB_G0278321", "Q54FU1", "DDB_G0290591" ] }, "reaction_10582493": { "compartment": "compartment_7660", "id": "reaction_10582493", "reactome": "R-DDI-83788", "name": "Binding of TFIIIC to Type 2 promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581829", "species_83747" ], "products": [ "species_10582491" ], "modifiers": [], "additional_components": [ "Q8T1F9", "DDB_G0275127", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54YB5", "DDB_G0278321", "Q54FU1", "DDB_G0290591", "Q8T1F9", "DDB_G0275127", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54YB5", "DDB_G0278321", "Q54FU1", "DDB_G0290591" ] }, "reaction_10588590": { "compartment": "compartment_70101", "id": "reaction_10588590", "reactome": "R-DDI-205039", "name": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10588141" ], "products": [ "species_10588143", "species_29420" ], "modifiers": [ [ "species_10588587", "catalyst" ] ], "additional_components": [ "species_29420", "P34144", "DDB_G0277869", "P34144", "DDB_G0277869", "species_29438", "Q54F88", "DDB_G0293396", "Q86HN1", "DDB_G0293396", "Q54G10", "DDB_G0293396", "Q86K95", "DDB_G0293396", "Q54GP2", "DDB_G0293396", "Q54J14", "DDB_G0288377", "Q54NG0", "DDB_G0293396", "Q54P24", "DDB_G0284845", "Q54P81", "DDB_G0293396", "Q54S15", "DDB_G0293396", "Q54SR5", "DDB_G0293396", "Q54VX2", "DDB_G0293396", "Q54XA7", "DDB_G0293396", "Q54XW8", "DDB_G0278703", "Q54BV5", "DDB_G0293396", "Q54YP1", "DDB_G0293396", "Q54BY9", "DDB_G0293396", "Q54YZ6", "DDB_G0277987", "Q54C56", "DDB_G0293396", "Q55DL8", "DDB_G0293396", "Q54DW7", "DDB_G0293396", "Q55G61", "DDB_G0268354", "Q54KI4", "DDB_G0287325", "Q8SSQ0", "DDB_G0274605", "Q54C94", "DDB_G0293006", "Q8IS11", "DDB_G0290267", "Q54FF3", "DDB_G0290901", "Q8SSW7", "DDB_G0271868", "Q8IS14", "DDB_G0277913", "Q8ST25", "DDB_G0272032", "Q54H95", "DDB_G0289613", "Q8IS15", "DDB_G0277915", "Q54PQ4", "DDB_G0284329", "Q8IS16", "DDB_G0276963", "Q54XL4", "DDB_G0289613", "Q8IS20", "DDB_G0282381", "Q55FD8", "DDB_G0268578", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q55GH9", "DDB_G0267666", "Q54SG9", "DDB_G0282475", "Q550V3", "DDB_G0277017", "Q54MM3", "DDB_G0291085", "Q54B37", "DDB_G0293978", "Q54F64", "DDB_G0291085", "Q54PK2", "DDB_G0291085", "Q1ZXN6", "DDB_G0272372", "Q54J11", "DDB_G0288383", "Q54L90", "DDB_G0286773", "Q54WL2", "DDB_G0279569", "Q552M5", "DDB_G0276019", "Q86G47", "DDB_G0289665", "Q8IS18", "DDB_G0269252", "Q8IS19", "DDB_G0289667", "Q8SSQ3", "DDB_G0274607" ] }, "reaction_10626822": { "compartment": "compartment_70101", "id": "reaction_10626822", "reactome": "R-DDI-9647978", "name": "pro-RAS proteins are farnesylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626748", "species_2530486" ], "products": [ "species_111294", "species_10626810" ], "modifiers": [ [ "species_10626817", "catalyst" ], [ "species_10626820", "inhibitor" ] ], "additional_components": [ "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "Q54QY0", "DDB_G0283547", "Q55CB0", "DDB_G0270138", "Q55CA9", "DDB_G0270140", "Q55CB8", "DDB_G0270124", "Q55CB7", "DDB_G0270126", "Q55CC0", "DDB_G0270122", "Q55CB9", "DDB_G0270736", "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "P32252", "DDB_G0292998", "P15064", "DDB_G0293434", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "Q54QY0", "DDB_G0283547", "Q55CB0", "DDB_G0270138", "Q55CA9", "DDB_G0270140", "Q55CB8", "DDB_G0270124", "Q55CB7", "DDB_G0270126", "Q55CC0", "DDB_G0270122", "Q55CB9", "DDB_G0270736", "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "Q54RT9", "DDB_G0283053", "Q55D51", "DDB_G0270948", "Q54RT9", "DDB_G0283053", "Q55D51", "DDB_G0270948" ] }, "reaction_10626891": { "compartment": "compartment_876", "id": "reaction_10626891", "reactome": "R-DDI-9647980", "name": "mature RAS proteins translocate to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626887" ], "products": [ "species_10626889" ], "modifiers": [], "additional_components": [ "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "P32252", "DDB_G0292998", "P15064", "DDB_G0293434", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "Q54QY0", "DDB_G0283547", "Q55CB0", "DDB_G0270138", "Q55CA9", "DDB_G0270140", "Q55CB8", "DDB_G0270124", "Q55CB7", "DDB_G0270126", "Q55CC0", "DDB_G0270122", "Q55CB9", "DDB_G0270736", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140" ] }, "reaction_10626920": { "compartment": "compartment_876", "id": "reaction_10626920", "reactome": "R-DDI-9647991", "name": "Palmostatin B binds RAS depalmitoylases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9647934", "species_10626916" ], "products": [ "species_10626918" ], "modifiers": [], "additional_components": [ "Q54F01", "DDB_G0291205", "Q54T49", "DDB_G0282005", "Q54F01", "DDB_G0291205", "Q54T49", "DDB_G0282005" ] }, "reaction_10626990": { "compartment": "compartment_70101", "id": "reaction_10626990", "reactome": "R-DDI-9653503", "name": "KRAS4B is phosphorylated on serine 181", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10585140" ], "products": [ "species_29370", "species_10626983" ], "modifiers": [ [ "species_10626987", "catalyst" ] ], "additional_components": [ "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "Q55CC0", "DDB_G0270122", "P15064", "DDB_G0293434", "P32253", "DDB_G0281385", "P32252", "DDB_G0292998", "Q75J93", "DDB_G0277381", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q55CA9", "DDB_G0270140", "Q54VD5", "DDB_G0280437", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "P03967", "DDB_G0292996", "Q55CB9", "DDB_G0270736", "Q55CB8", "DDB_G0270124", "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029", "species_30991" ] }, "reaction_10626925": { "compartment": "compartment_876", "id": "reaction_10626925", "reactome": "R-DDI-9647994", "name": "RAS proteins are depalmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10626889" ], "products": [ "species_10626922", "species_8848337" ], "modifiers": [ [ "species_10626916", "catalyst" ], [ "species_10626918", "inhibitor" ] ], "additional_components": [ "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "Q54F01", "DDB_G0291205", "Q54T49", "DDB_G0282005", "Q54F01", "DDB_G0291205", "Q54T49", "DDB_G0282005" ] }, "reaction_10626930": { "compartment": "compartment_876", "id": "reaction_10626930", "reactome": "R-DDI-9649733", "name": "mature p21 RAS binds GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29420", "species_10585142" ], "products": [ "species_10585874" ], "modifiers": [], "additional_components": [ "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29420" ] }, "reaction_10626994": { "compartment": "compartment_876", "id": "reaction_10626994", "reactome": "R-DDI-9653585", "name": "S-Farn-Me KRAS4B binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585140", "species_10583042" ], "products": [ "species_10626992" ], "modifiers": [ [ "species_10626983", "inhibitor" ] ], "additional_components": [ "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "Q55CC0", "DDB_G0270122", "P15064", "DDB_G0293434", "P32253", "DDB_G0281385", "P32252", "DDB_G0292998", "Q75J93", "DDB_G0277381", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q55CA9", "DDB_G0270140", "Q54VD5", "DDB_G0280437", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "P03967", "DDB_G0292996", "Q55CB9", "DDB_G0270736", "Q55CB8", "DDB_G0270124" ] }, "reaction_10627027": { "compartment": "compartment_17906", "id": "reaction_10627027", "reactome": "R-DDI-9653592", "name": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626983" ], "products": [ "species_10627025" ], "modifiers": [], "additional_components": [ "Q55CC0", "DDB_G0270122", "P15064", "DDB_G0293434", "P32253", "DDB_G0281385", "P32252", "DDB_G0292998", "Q75J93", "DDB_G0277381", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q55CA9", "DDB_G0270140", "Q54VD5", "DDB_G0280437", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "P03967", "DDB_G0292996", "Q55CB9", "DDB_G0270736", "Q55CB8", "DDB_G0270124", "Q55CA9", "DDB_G0270140", "Q54VD5", "DDB_G0280437", "Q55CB7", "DDB_G0270126", "Q55CB0", "DDB_G0270138", "Q55CB9", "DDB_G0270736", "Q55CB8", "DDB_G0270124", "Q75J93", "DDB_G0277381", "Q55CC0", "DDB_G0270122", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P32253", "DDB_G0281385", "P32252", "DDB_G0292998", "Q54QY0", "DDB_G0283547", "P32254", "DDB_G0283537" ] }, "reaction_10626928": { "compartment": "compartment_12045", "id": "reaction_10626928", "reactome": "R-DDI-9649732", "name": "Mature S-Farn-Me KRAS4B translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626679" ], "products": [ "species_10585140" ], "modifiers": [], "additional_components": [ "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "Q54QY0", "DDB_G0283547", "Q55CB0", "DDB_G0270138", "Q55CA9", "DDB_G0270140", "Q55CB8", "DDB_G0270124", "Q55CB7", "DDB_G0270126", "Q55CC0", "DDB_G0270122", "Q55CB9", "DDB_G0270736", "Q75J93", "DDB_G0277381", "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "P03967", "DDB_G0292996", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385" ] }, "reaction_10626903": { "compartment": "compartment_20699", "id": "reaction_10626903", "reactome": "R-DDI-9647982", "name": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626681", "species_200993" ], "products": [ "species_10626887", "species_76194" ], "modifiers": [ [ "species_10626900", "catalyst" ] ], "additional_components": [ "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "Q54QY0", "DDB_G0283547", "Q55CB0", "DDB_G0270138", "Q55CA9", "DDB_G0270140", "Q55CB8", "DDB_G0270124", "Q55CB7", "DDB_G0270126", "Q55CC0", "DDB_G0270122", "Q55CB9", "DDB_G0270736", "Q75J93", "DDB_G0277381", "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "P32252", "DDB_G0292998", "P15064", "DDB_G0293434", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "Q54QY0", "DDB_G0283547", "Q55CB0", "DDB_G0270138", "Q55CA9", "DDB_G0270140", "Q55CB8", "DDB_G0270124", "Q55CB7", "DDB_G0270126", "Q55CC0", "DDB_G0270122", "Q55CB9", "DDB_G0270736", "Q54RL6", "DDB_G0283039", "Q550I3", "DDB_G0277093" ] }, "reaction_10627061": { "compartment": "compartment_876", "id": "reaction_10627061", "reactome": "R-DDI-9654521", "name": "Calmodulin dissociates KRAS4B from the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626992" ], "products": [ "species_10627059" ], "modifiers": [], "additional_components": [ "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "Q55CA9", "DDB_G0270140", "Q54VD5", "DDB_G0280437", "Q55CB7", "DDB_G0270126", "Q55CB0", "DDB_G0270138", "Q55CB9", "DDB_G0270736", "Q55CB8", "DDB_G0270124", "Q75J93", "DDB_G0277381", "Q55CC0", "DDB_G0270122", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P32253", "DDB_G0281385", "P32252", "DDB_G0292998", "Q54QY0", "DDB_G0283547", "P32254", "DDB_G0283537" ] }, "reaction_10626905": { "compartment": "compartment_70101", "id": "reaction_10626905", "reactome": "R-DDI-9647987", "name": "FNTB inhibitors bind FNTA:FNTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9653479", "species_10626817" ], "products": [ "species_10626820" ], "modifiers": [], "additional_components": [ "Q54RT9", "DDB_G0283053", "Q55D51", "DDB_G0270948", "Q54RT9", "DDB_G0283053", "Q55D51", "DDB_G0270948" ] }, "reaction_10626685": { "compartment": "compartment_12045", "id": "reaction_10626685", "reactome": "R-DDI-9647977", "name": "ICMT methylates S-Farn RAS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626649", "species_71284" ], "products": [ "species_10626681", "species_71285" ], "modifiers": [ [ "species_10612819", "catalyst" ], [ "species_10626683", "inhibitor" ] ], "additional_components": [ "P15064", "DDB_G0293434", "Q55CA9", "DDB_G0270140", "Q54VD5", "DDB_G0280437", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "P03967", "DDB_G0292996", "Q55CB9", "DDB_G0270736", "Q55CB8", "DDB_G0270124", "Q55CC0", "DDB_G0270122", "P32253", "DDB_G0281385", "P32252", "DDB_G0292998", "Q75J93", "DDB_G0277381", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "Q54QY0", "DDB_G0283547", "Q55CB0", "DDB_G0270138", "Q55CA9", "DDB_G0270140", "Q55CB8", "DDB_G0270124", "Q55CB7", "DDB_G0270126", "Q55CC0", "DDB_G0270122", "Q55CB9", "DDB_G0270736", "Q75J93", "DDB_G0277381", "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "P03967", "DDB_G0292996", "Q558K8", "DDB_G0272799", "species_29426", "Q558K8", "DDB_G0272799", "species_29426" ] }, "reaction_10607347": { "compartment": "compartment_876", "id": "reaction_10607347", "reactome": "R-DDI-5675417", "name": "PEBP1 binds activated RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607343", "species_10607338" ], "products": [ "species_10607345" ], "modifiers": [], "additional_components": [ "DDB_G0283803", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54QK0", "DDB_G0283803" ] }, "reaction_10607267": { "compartment": "compartment_876", "id": "reaction_10607267", "reactome": "R-DDI-5674018", "name": "BRAP binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607263", "species_10585144" ], "products": [ "species_10607265" ], "modifiers": [], "additional_components": [ "DDB_G0270200", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q55C68", "DDB_G0270200" ] }, "reaction_10607319": { "compartment": "compartment_20699", "id": "reaction_10607319", "reactome": "R-DDI-5674140", "name": "PAQR3 binds inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606974", "species_10607315" ], "products": [ "species_10607317" ], "modifiers": [], "additional_components": [ "DDB_G0281557", "Q54FT1", "DDB_G0293838", "Q54B86", "DDB_G0293838", "Q54CB4", "DDB_G0293838", "Q54FT1", "DDB_G0293838", "Q54B86", "DDB_G0293838", "Q54CB4", "DDB_G0293838", "Q54TM7", "DDB_G0281557" ] }, "reaction_10607367": { "compartment": "compartment_876", "id": "reaction_10607367", "reactome": "R-DDI-5675433", "name": "PP5 dephosphorylates RAF1 S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10607338" ], "products": [ "species_29372", "species_10607351" ], "modifiers": [ [ "species_10607364", "catalyst" ] ], "additional_components": [ "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "DDB_G0283157" ] }, "reaction_10607271": { "compartment": "compartment_70101", "id": "reaction_10607271", "reactome": "R-DDI-5674019", "name": "BRAP binds KSR1:MARK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606927", "species_10607263" ], "products": [ "species_10607269" ], "modifiers": [], "additional_components": [ "Q1ZXD6", "DDB_G0294533", "Q54WS5", "DDB_G0279417", "Q23915", "DDB_G0283391", "Q869X3", "DDB_G0282895", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54VC0", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "DDB_G0270200", "Q55C68", "DDB_G0270200", "Q1ZXD6", "DDB_G0294533", "Q54WS5", "DDB_G0279417", "Q23915", "DDB_G0283391", "Q869X3", "DDB_G0282895", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54VC0", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304" ] }, "reaction_10607279": { "compartment": "compartment_876", "id": "reaction_10607279", "reactome": "R-DDI-5674022", "name": "BRAP autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10607265" ], "products": [ "species_10607276" ], "modifiers": [ [ "species_10607265", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q55C68", "DDB_G0270200", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q55C68", "DDB_G0270200", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q55C68", "DDB_G0270200" ] }, "reaction_10607358": { "compartment": "compartment_876", "id": "reaction_10607358", "reactome": "R-DDI-5675431", "name": "PP2A dephosphorylates RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10607351" ], "products": [ "species_29372", "species_10607355" ], "modifiers": [ [ "species_10590274", "catalyst" ], [ "species_10607330", "catalyst" ] ], "additional_components": [ "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "DDB_G0281557" ] }, "reaction_10626932": { "compartment": "compartment_876", "id": "reaction_10626932", "reactome": "R-DDI-9649735", "name": "Intrinsic nucleotide exchange on RAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10585874" ], "products": [ "species_29420", "species_10585144" ], "modifiers": [], "additional_components": [ "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29420", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438" ] }, "reaction_10627146": { "compartment": "compartment_876", "id": "reaction_10627146", "reactome": "R-DDI-9660557", "name": "RAS:GTP binds RAL GDS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627140", "species_10627142" ], "products": [ "species_10627144" ], "modifiers": [], "additional_components": [ "Q8SSQ3", "DDB_G0274607", "Q54WL2", "DDB_G0279569", "Q54L90", "DDB_G0286773", "Q86G47", "DDB_G0289665", "Q552M5", "DDB_G0276019", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "P15064", "DDB_G0293434", "species_29438", "P15064", "DDB_G0293434", "species_29438", "Q8SSQ3", "DDB_G0274607", "Q54WL2", "DDB_G0279569", "Q54L90", "DDB_G0286773", "Q86G47", "DDB_G0289665", "Q552M5", "DDB_G0276019", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252" ] }, "reaction_10626937": { "compartment": "compartment_876", "id": "reaction_10626937", "reactome": "R-DDI-9649736", "name": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585144" ], "products": [ "species_10585874" ], "modifiers": [ [ "species_10585144", "catalyst" ] ], "additional_components": [ "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29420", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438" ] }, "reaction_10607066": { "compartment": "compartment_876", "id": "reaction_10607066", "reactome": "R-DDI-5672965", "name": "RAS GEFs promote RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10585874" ], "products": [ "species_29420", "species_10585144" ], "modifiers": [ [ "species_10607063", "catalyst" ] ], "additional_components": [ "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29420", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q8IS14", "DDB_G0277913", "Q8IS15", "DDB_G0277915", "Q8IS16", "DDB_G0276963", "Q8IS20", "DDB_G0282381", "Q8IS21", "DDB_G0269222", "Q8SSQ0", "DDB_G0274605", "Q8SSW7", "DDB_G0271868", "B0M0P8", "DDB_G0276371", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q54FF3", "DDB_G0290901", "Q54H95", "DDB_G0289613", "Q54PQ4", "DDB_G0284329", "Q54XL4", "DDB_G0289613", "Q55FD8", "DDB_G0268578", "Q55GH9", "DDB_G0267666", "Q8IS11", "DDB_G0290267", "species_6797635", "Q54TK8", "DDB_G0281573", "Q8IS12", "DDB_G0275703", "Q54L90", "DDB_G0286773", "Q54WL2", "DDB_G0279569", "Q552M5", "DDB_G0276019", "Q86G47", "DDB_G0289665", "Q8IS18", "DDB_G0269252", "Q8IS19", "DDB_G0289667", "Q8SSQ3", "DDB_G0274607" ] }, "reaction_10626939": { "compartment": "compartment_876", "id": "reaction_10626939", "reactome": "R-DDI-9653108", "name": "Raf dimer inhibitors bind RAF heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607149", "species_9657579" ], "products": [ "species_10607251" ], "modifiers": [], "additional_components": [ "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438" ] }, "reaction_10606970": { "compartment": "compartment_70101", "id": "reaction_10606970", "reactome": "R-DDI-5672948", "name": "MARK3 phosphorylates KSR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606927", "species_113592" ], "products": [ "species_29370", "species_10606967" ], "modifiers": [ [ "species_10606927", "catalyst" ] ], "additional_components": [ "Q1ZXD6", "DDB_G0294533", "Q54WS5", "DDB_G0279417", "Q23915", "DDB_G0283391", "Q869X3", "DDB_G0282895", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54VC0", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q1ZXD6", "DDB_G0294533", "Q54RZ7", "DDB_G0282895", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54TH6", "DDB_G0282895", "Q54GY6", "DDB_G0289859", "Q54VC0", "DDB_G0282895", "Q54H05", "DDB_G0289661", "Q54WS5", "DDB_G0279417", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q1ZXD6", "DDB_G0294533", "Q54WS5", "DDB_G0279417", "Q23915", "DDB_G0283391", "Q869X3", "DDB_G0282895", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54VC0", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304" ] }, "reaction_10606562": { "compartment": "compartment_70101", "id": "reaction_10606562", "reactome": "R-DDI-5658424", "name": "KBTBD7:CUL3:RBX1 ubiquitinates NF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10606525" ], "products": [ "species_10606557" ], "modifiers": [ [ "species_10606559", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q5TJ65", "DDB_G0289541", "Q54WD0", "DDB_G0282941", "Q54Y08", "DDB_G0278483", "Q55AR6", "DDB_G0271750", "Q86JJ7", "DDB_G0282941", "Q8SSU4", "DDB_G0282941", "Q54Q13", "DDB_G0284177", "Q54RT3", "DDB_G0282941", "Q5TJ65", "DDB_G0289541", "Q54Y08", "DDB_G0278483", "Q55AR6", "DDB_G0271750", "Q54Q13", "DDB_G0284177", "Q86JJ7", "DDB_G0282941", "Q8SSU4", "DDB_G0282941", "Q54RT3", "DDB_G0282941", "Q54WD0", "DDB_G0282941", "Q55BF8", "DDB_G0271372", "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903" ] }, "reaction_10606532": { "compartment": "compartment_876", "id": "reaction_10606532", "reactome": "R-DDI-5658231", "name": "RAS GAPs stimulate RAS GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606529" ], "products": [ "species_10606527", "species_10585874" ], "modifiers": [ [ "species_10606529", "catalyst" ] ], "additional_components": [ "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54Q13", "DDB_G0284177", "Q86JJ7", "DDB_G0282941", "Q54WD0", "DDB_G0282941", "Q54Y08", "DDB_G0278483", "Q8SSU4", "DDB_G0282941", "Q54RT3", "DDB_G0282941", "Q55AR6", "DDB_G0271750", "Q5TJ65", "DDB_G0289541", "Q54Q13", "DDB_G0284177", "Q86JJ7", "DDB_G0282941", "Q54WD0", "DDB_G0282941", "Q54Y08", "DDB_G0278483", "Q8SSU4", "DDB_G0282941", "Q54RT3", "DDB_G0282941", "Q55AR6", "DDB_G0271750", "Q5TJ65", "DDB_G0289541", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29420", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54Q13", "DDB_G0284177", "Q86JJ7", "DDB_G0282941", "Q54WD0", "DDB_G0282941", "Q54Y08", "DDB_G0278483", "Q8SSU4", "DDB_G0282941", "Q54RT3", "DDB_G0282941", "Q55AR6", "DDB_G0271750", "Q5TJ65", "DDB_G0289541" ] }, "reaction_10606564": { "compartment": "compartment_70101", "id": "reaction_10606564", "reactome": "R-DDI-5658430", "name": "NF1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606557" ], "products": [ "species_10606507" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q5TJ65", "DDB_G0289541", "Q54Y08", "DDB_G0278483", "Q55AR6", "DDB_G0271750", "Q54Q13", "DDB_G0284177", "Q86JJ7", "DDB_G0282941", "Q8SSU4", "DDB_G0282941", "Q54RT3", "DDB_G0282941", "Q54WD0", "DDB_G0282941", "Q5TJ65", "DDB_G0289541", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10606566": { "compartment": "compartment_876", "id": "reaction_10606566", "reactome": "R-DDI-5658435", "name": "RAS GAPs bind RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606527", "species_10585144" ], "products": [ "species_10606529" ], "modifiers": [], "additional_components": [ "Q54Q13", "DDB_G0284177", "Q86JJ7", "DDB_G0282941", "Q54WD0", "DDB_G0282941", "Q54Y08", "DDB_G0278483", "Q8SSU4", "DDB_G0282941", "Q54RT3", "DDB_G0282941", "Q55AR6", "DDB_G0271750", "Q5TJ65", "DDB_G0289541", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54Q13", "DDB_G0284177", "Q86JJ7", "DDB_G0282941", "Q54WD0", "DDB_G0282941", "Q54Y08", "DDB_G0278483", "Q8SSU4", "DDB_G0282941", "Q54RT3", "DDB_G0282941", "Q55AR6", "DDB_G0271750", "Q5TJ65", "DDB_G0289541" ] }, "reaction_10606568": { "compartment": "compartment_876", "id": "reaction_10606568", "reactome": "R-DDI-5658438", "name": "SPRED dimer binds NF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606523", "species_10606507" ], "products": [ "species_10606525" ], "modifiers": [], "additional_components": [ "Q54WD0", "DDB_G0282941", "Q54Y08", "DDB_G0278483", "Q55AR6", "DDB_G0271750", "Q86JJ7", "DDB_G0282941", "Q8SSU4", "DDB_G0282941", "Q54Q13", "DDB_G0284177", "Q54RT3", "DDB_G0282941", "Q5TJ65", "DDB_G0289541", "Q5TJ65", "DDB_G0289541", "Q54WD0", "DDB_G0282941", "Q54Y08", "DDB_G0278483", "Q55AR6", "DDB_G0271750", "Q86JJ7", "DDB_G0282941", "Q8SSU4", "DDB_G0282941", "Q54Q13", "DDB_G0284177", "Q54RT3", "DDB_G0282941" ] }, "reaction_10583296": { "compartment": "compartment_7660", "id": "reaction_10583296", "reactome": "R-DDI-112392", "name": "Resumption of elongation after recovery from pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583294" ], "products": [ "species_10583290" ], "modifiers": [], "additional_components": [ "Q75JA4", "DDB_G0271690", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10583300": { "compartment": "compartment_7660", "id": "reaction_10583300", "reactome": "R-DDI-112395", "name": "Abortive termination of elongation after arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583290" ], "products": [ "species_10583298" ], "modifiers": [], "additional_components": [ "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q75JA4", "DDB_G0271690", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10581640": { "compartment": "compartment_7660", "id": "reaction_10581640", "reactome": "R-DDI-75862", "name": "Fall Back to Closed Pre-initiation Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581630" ], "products": [ "species_10581638" ], "modifiers": [], "additional_components": [ "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54FD6", "DDB_G0290929", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307" ] }, "reaction_10581740": { "compartment": "compartment_7660", "id": "reaction_10581740", "reactome": "R-DDI-75891", "name": "Abortive Initiation After Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581738" ], "products": [ "species_10580922", "species_10580699", "species_10578889", "species_75897" ], "modifiers": [], "additional_components": [ "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10583308": { "compartment": "compartment_7660", "id": "reaction_10583308", "reactome": "R-DDI-112429", "name": "Formation of FACT complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583209", "species_10583204" ], "products": [ "species_10583211" ], "modifiers": [], "additional_components": [ "DDB_G0282677", "DDB_G0290331", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677" ] }, "reaction_10583310": { "compartment": "compartment_7660", "id": "reaction_10583310", "reactome": "R-DDI-112430", "name": "Formation of P-TEFb complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583129", "species_10583140" ], "products": [ "species_10583142" ], "modifiers": [], "additional_components": [ "DDB_G0273207", "Q54LJ0", "DDB_G0286617", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207" ] }, "reaction_10583312": { "compartment": "compartment_7660", "id": "reaction_10583312", "reactome": "R-DDI-112434", "name": "Formation of DSIF complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582382", "species_10583163" ], "products": [ "species_10583165" ], "modifiers": [], "additional_components": [ "DDB_G0287661", "DDB_G0285293", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661" ] }, "reaction_10583316": { "compartment": "compartment_7660", "id": "reaction_10583316", "reactome": "R-DDI-113409", "name": "Abortive termination of early transcription elongation by DSIF:NELF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583219" ], "products": [ "species_10583219" ], "modifiers": [], "additional_components": [ "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q75JA4", "DDB_G0271690", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q75JA4", "DDB_G0271690", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195" ] }, "reaction_10583318": { "compartment": "compartment_7660", "id": "reaction_10583318", "reactome": "R-DDI-113411", "name": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583290" ], "products": [ "species_10583294" ], "modifiers": [], "additional_components": [ "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q75JA4", "DDB_G0271690", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10583322": { "compartment": "compartment_7660", "id": "reaction_10583322", "reactome": "R-DDI-113413", "name": "TFIIS-mediated recovery of elongation from arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583290" ], "products": [ "species_10583290" ], "modifiers": [], "additional_components": [ "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10581628": { "compartment": "compartment_7660", "id": "reaction_10581628", "reactome": "R-DDI-75856", "name": "Abortive Initiation Before Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581626" ], "products": [ "species_10580910", "species_10580844", "species_10580922", "species_10580699", "species_10578889", "species_10580839", "species_110068" ], "modifiers": [], "additional_components": [ "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "DDB_G0290929", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343" ] }, "reaction_10583324": { "compartment": "compartment_7660", "id": "reaction_10583324", "reactome": "R-DDI-113414", "name": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583290" ], "products": [ "species_10583290" ], "modifiers": [], "additional_components": [ "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10580926": { "compartment": "compartment_7660", "id": "reaction_10580926", "reactome": "R-DDI-73946", "name": "Abortive initiation after formation of the first phosphodiester bond", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580924" ], "products": [ "species_10580910", "species_10580844", "species_10580922", "species_10580699", "species_10578889", "species_10580839", "species_109877" ], "modifiers": [], "additional_components": [ "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "DDB_G0290929", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343" ] }, "reaction_10626417": { "compartment": "compartment_17938", "id": "reaction_10626417", "reactome": "R-DDI-9639287", "name": "SESN1,2 binds L-leucine and dissociates from GATOR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626411", "species_29588" ], "products": [ "species_10626413", "species_10626415" ], "modifiers": [], "additional_components": [ "Q54WU6", "DDB_G0279427", "Q86K39", "DDB_G0277257", "Q54JS5", "DDB_G0287817", "Q54DS4", "DDB_G0292056", "Q54DS8", "DDB_G0292052", "Q551B5", "DDB_G0276673", "Q54XA2", "DDB_G0279099", "Q55BD9", "DDB_G0271288", "Q54UN5", "DDB_G0280947", "Q54NW3", "DDB_G0284957", "Q54Y15", "DDB_G0278475", "Q86IH5", "DDB_G0272696", "Q55DE8", "DDB_G0269680", "Q54XA2", "DDB_G0279099", "Q55BD9", "DDB_G0271288", "Q54UN5", "DDB_G0280947", "Q54NW3", "DDB_G0284957", "Q54Y15", "DDB_G0278475", "Q86IH5", "DDB_G0272696", "Q55DE8", "DDB_G0269680", "Q86K39", "DDB_G0277257", "Q54JS5", "DDB_G0287817", "Q54DS4", "DDB_G0292056", "Q54DS8", "DDB_G0292052", "Q551B5", "DDB_G0276673", "species_29588", "Q54WU6", "DDB_G0279427" ] }, "reaction_10626343": { "compartment": "compartment_17938", "id": "reaction_10626343", "reactome": "R-DDI-9639286", "name": "RRAGC,D exchanges GTP for GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584158", "species_10626430" ], "products": [ "species_10626432" ], "modifiers": [], "additional_components": [ "Q54DD9", "DDB_G0292318", "species_29438", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q55AH5", "DDB_G0271882", "Q86A77", "DDB_G0274331", "O00780", "DDB_G0275701", "Q54Z13", "DDB_G0277971", "Q76NU1", "DDB_G0277401", "P54648", "DDB_G0284473", "Q86AS7", "DDB_G0274141", "Q54E04", "DDB_G0291858", "P54642", "DDB_G0274381", "P54641", "DDB_G0273071", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q55AH5", "DDB_G0271882", "Q86A77", "DDB_G0274331", "O00780", "DDB_G0275701", "Q54Z13", "DDB_G0277971", "Q76NU1", "DDB_G0277401", "P54648", "DDB_G0284473", "Q86AS7", "DDB_G0274141", "Q54E04", "DDB_G0291858", "P54642", "DDB_G0274381", "P54641", "DDB_G0273071", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q54DD9", "DDB_G0292318" ] }, "reaction_10626428": { "compartment": "compartment_17938", "id": "reaction_10626428", "reactome": "R-DDI-9640167", "name": "RRAGA,B exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10626421" ], "products": [ "species_29420", "species_10626425" ], "modifiers": [ [ "species_10626421", "catalyst" ] ], "additional_components": [ "species_29468", "Q54IK1", "DDB_G0288701", "species_29420", "Q54PK6", "DDB_G0284495", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q55AH5", "DDB_G0271882", "Q86A77", "DDB_G0274331", "O00780", "DDB_G0275701", "Q54Z13", "DDB_G0277971", "Q76NU1", "DDB_G0277401", "P54648", "DDB_G0284473", "Q86AS7", "DDB_G0274141", "Q54E04", "DDB_G0291858", "P54642", "DDB_G0274381", "P54641", "DDB_G0273071", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "species_29468", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q55AH5", "DDB_G0271882", "Q86A77", "DDB_G0274331", "O00780", "DDB_G0275701", "Q54Z13", "DDB_G0277971", "Q76NU1", "DDB_G0277401", "P54648", "DDB_G0284473", "Q86AS7", "DDB_G0274141", "Q54E04", "DDB_G0291858", "P54642", "DDB_G0274381", "P54641", "DDB_G0273071", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "species_29468", "Q54IK1", "DDB_G0288701", "species_29420", "Q54PK6", "DDB_G0284495", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q55AH5", "DDB_G0271882", "Q86A77", "DDB_G0274331", "O00780", "DDB_G0275701", "Q54Z13", "DDB_G0277971", "Q76NU1", "DDB_G0277401", "P54648", "DDB_G0284473", "Q86AS7", "DDB_G0274141", "Q54E04", "DDB_G0291858", "P54642", "DDB_G0274381", "P54641", "DDB_G0273071", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567" ] }, "reaction_10606133": { "compartment": "compartment_7660", "id": "reaction_10606133", "reactome": "R-DDI-5635854", "name": "GLI2,3 are degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606131" ], "products": [ "species_10576865", "species_10606129" ], "modifiers": [ [ "species_10585327", "catalyst" ] ], "additional_components": [ "Q54D90", "DDB_G0292428", "Q54WU7", "DDB_G0292428", "Q55E93", "DDB_G0269338", "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54D90", "DDB_G0292428", "Q54WU7", "DDB_G0292428", "Q55E93", "DDB_G0269338", "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903", "Q27563", "DDB_G0267408", "P02889", "DDB_G0272564", "P34119", "DDB_G0280969", "Q552Y8", "DDB_G0275753", "Q55G04", "DDB_G0268538", "Q967U1", "DDB_G0285099", "Q54XM7", "DDB_G0278847", "P34120", "DDB_G0272831", "Q86A21", "DDB_G0272969", "Q54S82", "DDB_G0282617", "Q54QR2", "DDB_G0283679", "Q55DY7", "DDB_G0269472", "Q55D66", "DDB_G0269772", "Q556Q0", "DDB_G0273163", "Q54BC8", "DDB_G0293784", "Q55GJ6", "DDB_G0267390", "Q55BV5", "DDB_G0270784", "Q86JA1", "DDB_G0276917", "Q54PN7", "DDB_G0284415", "P34123", "DDB_G0289003", "P34124", "DDB_G0292382", "Q54PJ1", "DDB_G0284517", "Q54JM5", "DDB_G0287953", "Q54HW1", "DDB_G0289189", "Q54UB5", "DDB_G0281315", "Q54UJ0", "DDB_G0281051", "Q54NQ0", "DDB_G0285105", "Q54BC6", "DDB_G0293752", "Q1ZXD3", "DDB_G0288621", "Q553E0", "DDB_G0275775", "Q86IJ1", "DDB_G0272566", "Q559F4", "DDB_G0272951", "Q27562", "DDB_G0282363", "Q55C75", "DDB_G0270188", "Q54DM7", "DDB_G0292122", "Q54WI8", "DDB_G0279633" ] }, "reaction_10606140": { "compartment": "compartment_7660", "id": "reaction_10606140", "reactome": "R-DDI-5635856", "name": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606137", "species_10576865" ], "products": [ "species_10606131" ], "modifiers": [ [ "species_10606137", "catalyst" ] ], "additional_components": [ "Q54D90", "DDB_G0292428", "Q54WU7", "DDB_G0292428", "Q55E93", "DDB_G0269338", "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54D90", "DDB_G0292428", "Q54WU7", "DDB_G0292428", "Q55E93", "DDB_G0269338", "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903", "Q54D90", "DDB_G0292428", "Q54WU7", "DDB_G0292428", "Q55E93", "DDB_G0269338", "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903" ] }, "reaction_10595044": { "compartment": "compartment_70101", "id": "reaction_10595044", "reactome": "R-DDI-936563", "name": "ISGylation of DDX58", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10595002", "species_10595040" ], "products": [ "species_10595042" ], "modifiers": [], "additional_components": [ "DDB_G0294407", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q55C16", "DDB_G0270272", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q55C16", "DDB_G0270272", "Q86L44", "DDB_G0294407" ] }, "reaction_10605345": { "compartment": "compartment_12045", "id": "reaction_10605345", "reactome": "R-DDI-5362412", "name": "SYVN1 ubiquitinates Hh C-terminal fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10605338" ], "products": [ "species_10605342" ], "modifiers": [ [ "species_10605338", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q86H64", "DDB_G0275851", "Q54IC9", "DDB_G0288833", "P90532", "DDB_G0288065", "Q54JQ6", "DDB_G0287847", "Q55E19", "DDB_G0269430", "Q54IC9", "DDB_G0288833", "P90532", "DDB_G0288065", "Q54JQ6", "DDB_G0287847", "Q55E19", "DDB_G0269430", "Q86H64", "DDB_G0275851", "Q86H64", "DDB_G0275851", "Q54IC9", "DDB_G0288833", "P90532", "DDB_G0288065", "Q54JQ6", "DDB_G0287847", "Q55E19", "DDB_G0269430" ] }, "reaction_10593912": { "compartment": "compartment_876", "id": "reaction_10593912", "reactome": "R-DDI-507868", "name": "Aquaporins passively transport water into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10593909", "catalyst" ] ], "additional_components": [ "Q9U8P7", "DDB_G0267378", "Q54WT8", "DDB_G0279443", "Q54FQ9", "DDB_G0290691", "Q54V53", "DDB_G0280537" ] }, "reaction_10593914": { "compartment": "compartment_876", "id": "reaction_10593914", "reactome": "R-DDI-507870", "name": "Aquaporins passively transport water out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10593909", "catalyst" ] ], "additional_components": [ "Q9U8P7", "DDB_G0267378", "Q54WT8", "DDB_G0279443", "Q54FQ9", "DDB_G0290691", "Q54V53", "DDB_G0280537" ] }, "reaction_10587219": { "compartment": "compartment_876", "id": "reaction_10587219", "reactome": "R-DDI-199443", "name": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587026", "species_10587009" ], "products": [ "species_10587028" ], "modifiers": [], "additional_components": [ "DDB_G0273293", "species_179838", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_179838", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "Q556W3", "DDB_G0273293" ] }, "reaction_10619666": { "compartment": "compartment_984", "id": "reaction_10619666", "reactome": "R-DDI-8862300", "name": "LYZ binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6789198", "species_10614528" ], "products": [ "species_10619664" ], "modifiers": [], "additional_components": [ "Q54F36", "DDB_G0291137", "Q54XV8", "DDB_G0278563", "Q8MML4", "DDB_G0274551", "Q54F36", "DDB_G0291137", "Q54XV8", "DDB_G0278563", "Q8MML4", "DDB_G0274551", "species_6789198" ] }, "reaction_10619669": { "compartment": "compartment_984", "id": "reaction_10619669", "reactome": "R-DDI-8862320", "name": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10619664" ], "products": [ "species_6788991", "species_6788982" ], "modifiers": [ [ "species_10619664", "catalyst" ] ], "additional_components": [ "Q54F36", "DDB_G0291137", "Q54XV8", "DDB_G0278563", "Q8MML4", "DDB_G0274551", "species_6789198", "species_1236719", "CHEBI:21615", "Q54F36", "DDB_G0291137", "Q54XV8", "DDB_G0278563", "Q8MML4", "DDB_G0274551", "species_6789198" ] }, "reaction_10616763": { "compartment": "compartment_984", "id": "reaction_10616763", "reactome": "R-DDI-6807585", "name": "BPI binds LPS on the bacterial surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803081", "species_10584365" ], "products": [ "species_10616761" ], "modifiers": [], "additional_components": [ "DDB_G0271242", "Q55BA2", "DDB_G0271242", "species_166005" ] }, "reaction_10603621": { "compartment": "compartment_7660", "id": "reaction_10603621", "reactome": "R-DDI-4411373", "name": "NLK translocates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603605" ], "products": [ "species_10603619" ], "modifiers": [], "additional_components": [ "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "P42525", "DDB_G0286353", "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q54US6", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54V83", "DDB_G0280855", "Q554L2", "DDB_G0280855" ] }, "reaction_10603684": { "compartment": "compartment_70101", "id": "reaction_10603684", "reactome": "R-DDI-4551465", "name": "Translocation of NFATC1:CaN:CaM to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603678" ], "products": [ "species_10603682" ], "modifiers": [], "additional_components": [ "species_74112", "Q55G87", "DDB_G0267446", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "species_29426", "Q7YSW8", "DDB_G0276883", "CHEBI:29034", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "species_74112", "Q7YSW8", "DDB_G0276883", "CHEBI:29034", "species_29426", "Q55G87", "DDB_G0267446" ] }, "reaction_10603543": { "compartment": "compartment_70101", "id": "reaction_10603543", "reactome": "R-DDI-4086392", "name": "PDE6 hydrolyses cGMP to GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30991", "species_29356" ], "products": [ "species_113578" ], "modifiers": [ [ "species_10603540", "catalyst" ] ], "additional_components": [ "B0G0Y8", "DDB_G0268634", "species_29438", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343" ] }, "reaction_10622131": { "compartment": "compartment_70101", "id": "reaction_10622131", "reactome": "R-DDI-8875871", "name": "SLC26A11 transports SO4(2-) from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648" ], "products": [ "species_174375" ], "modifiers": [ [ "species_10622128", "catalyst" ] ], "additional_components": [ "DDB_G0268074" ] }, "reaction_10591543": { "compartment": "compartment_876", "id": "reaction_10591543", "reactome": "R-DDI-427666", "name": "SLC26A3,6 exchange Cl- for HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_111627" ], "products": [ "species_425425", "species_352022" ], "modifiers": [ [ "species_10591540", "catalyst" ] ], "additional_components": [ "Q55FK8", "DDB_G0286611", "B0G157", "DDB_G0286611" ] }, "reaction_10591526": { "compartment": "compartment_876", "id": "reaction_10591526", "reactome": "R-DDI-427570", "name": "Group 3 - Selective Cl- transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10591523", "catalyst" ] ], "additional_components": [ "B0G157", "DDB_G0286611", "Q55FK8", "DDB_G0286611" ] }, "reaction_10605910": { "compartment": "compartment_70101", "id": "reaction_10605910", "reactome": "R-DDI-5627802", "name": "SLC26A4 transports I- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209785" ], "products": [ "species_209818" ], "modifiers": [ [ "species_10605907", "catalyst" ] ], "additional_components": [ "Q55FK8", "DDB_G0286611", "B0G157", "DDB_G0286611" ] }, "reaction_10605187": { "compartment": "compartment_70101", "id": "reaction_10605187", "reactome": "R-DDI-5340130", "name": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428040", "species_5673778" ], "products": [ "species_70106", "species_379444" ], "modifiers": [ [ "species_10605184", "catalyst" ] ], "additional_components": [ "DDB_G0279445" ] }, "reaction_10591393": { "compartment": "compartment_876", "id": "reaction_10591393", "reactome": "R-DDI-425994", "name": "Na+/H+ exchanger transport (at cell membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_74113" ], "products": [ "species_351626", "species_83910" ], "modifiers": [ [ "species_10591390", "catalyst" ] ], "additional_components": [ "Q54TB5", "DDB_G0281877", "Q552S0", "DDB_G0275711" ] }, "reaction_10591341": { "compartment": "compartment_172574", "id": "reaction_10591341", "reactome": "R-DDI-425965", "name": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425999", "species_83910" ], "products": [ "species_425977", "species_70106" ], "modifiers": [ [ "species_10591338", "catalyst" ] ], "additional_components": [ "Q54TB5", "DDB_G0281877", "Q552S0", "DDB_G0275711" ] }, "reaction_10591358": { "compartment": "compartment_171062", "id": "reaction_10591358", "reactome": "R-DDI-425983", "name": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425978", "species_83910" ], "products": [ "species_70106", "species_425971" ], "modifiers": [ [ "species_10591355", "catalyst" ] ], "additional_components": [ "Q552S0", "DDB_G0275711", "Q54TB5", "DDB_G0281877" ] }, "reaction_10591406": { "compartment": "compartment_20699", "id": "reaction_10591406", "reactome": "R-DDI-426015", "name": "Na+/H+ exchanger transport (at trans-golgi membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425969", "species_83910" ], "products": [ "species_70106", "species_425958" ], "modifiers": [ [ "species_10591403", "catalyst" ] ], "additional_components": [ "Q54TB5", "DDB_G0281877", "Q552S0", "DDB_G0275711" ] }, "reaction_10591664": { "compartment": "compartment_876", "id": "reaction_10591664", "reactome": "R-DDI-428609", "name": "Type I Na+-coupled phosphate co-transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109277", "species_74113" ], "products": [ "species_29372", "species_83910" ], "modifiers": [ [ "species_10591661", "catalyst" ] ], "additional_components": [ "Q54UX4", "DDB_G0280761", "Q54W37", "DDB_G0280761" ] }, "reaction_10622115": { "compartment": "compartment_70101", "id": "reaction_10622115", "reactome": "R-DDI-8875623", "name": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_70106" ], "products": [ "species_113529", "species_113552" ], "modifiers": [ [ "species_10622110", "catalyst" ] ], "additional_components": [ "DDB_G0283329" ] }, "reaction_10591574": { "compartment": "compartment_201753", "id": "reaction_10591574", "reactome": "R-DDI-428052", "name": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_428548" ], "products": [ "species_70106", "species_428614" ], "modifiers": [ [ "species_10591571", "catalyst" ] ], "additional_components": [ "Q54UX4", "DDB_G0280761", "Q54W37", "DDB_G0280761" ] }, "reaction_10593024": { "compartment": "compartment_70101", "id": "reaction_10593024", "reactome": "R-DDI-450095", "name": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10586023", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10624195": { "compartment": "compartment_70101", "id": "reaction_10624195", "reactome": "R-DDI-8981570", "name": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10624192", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10591744": { "compartment": "compartment_876", "id": "reaction_10591744", "reactome": "R-DDI-428779", "name": "GLUT7 and GLUT11 transport glucose and fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428819" ], "products": [ "species_428802" ], "modifiers": [ [ "species_10591741", "catalyst" ] ], "additional_components": [ "species_70113", "species_29532", "species_70113", "species_29532", "Q54Z55", "DDB_G0277773", "Q54CM5", "DDB_G0292814" ] }, "reaction_10591780": { "compartment": "compartment_876", "id": "reaction_10591780", "reactome": "R-DDI-429094", "name": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10591777", "catalyst" ] ], "additional_components": [ "Q54M69", "DDB_G0286151", "Q54UC8", "DDB_G0281155" ] }, "reaction_10624197": { "compartment": "compartment_70101", "id": "reaction_10624197", "reactome": "R-DDI-8981574", "name": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10586023", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10605166": { "compartment": "compartment_70101", "id": "reaction_10605166", "reactome": "R-DDI-5339524", "name": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10593015", "catalyst" ], [ "species_113592", "inhibitor" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10591761": { "compartment": "compartment_876", "id": "reaction_10591761", "reactome": "R-DDI-429036", "name": "SLC2A9 transports Fru, Glc, urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429078" ], "products": [ "species_429148" ], "modifiers": [ [ "species_10591758", "catalyst" ] ], "additional_components": [ "species_70113", "species_30034", "species_29532", "species_70113", "species_30034", "species_29532", "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10624179": { "compartment": "compartment_70101", "id": "reaction_10624179", "reactome": "R-DDI-8981553", "name": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10624176", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10593019": { "compartment": "compartment_70101", "id": "reaction_10593019", "reactome": "R-DDI-450088", "name": "GLUT1 tetramer binds 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10593015" ], "products": [ "species_10593017" ], "modifiers": [], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773", "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773", "species_113592" ] }, "reaction_10624184": { "compartment": "compartment_70101", "id": "reaction_10624184", "reactome": "R-DDI-8981564", "name": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10624181", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814" ] }, "reaction_10622136": { "compartment": "compartment_70101", "id": "reaction_10622136", "reactome": "R-DDI-8875902", "name": "SLC45A3 transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10622133", "catalyst" ] ], "additional_components": [ "DDB_G0276801" ] }, "reaction_10593021": { "compartment": "compartment_70101", "id": "reaction_10593021", "reactome": "R-DDI-450092", "name": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593017" ], "products": [ "species_113592", "species_10593015" ], "modifiers": [], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773", "species_113592", "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10622268": { "compartment": "compartment_70101", "id": "reaction_10622268", "reactome": "R-DDI-8876319", "name": "SLC50A1 transports Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10622265", "catalyst" ] ], "additional_components": [ "DDB_G0287763" ] }, "reaction_10623330": { "compartment": "compartment_13231", "id": "reaction_10623330", "reactome": "R-DDI-8944457", "name": "MAF1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623321" ], "products": [ "species_10623319" ], "modifiers": [ [ "species_10584242", "inhibitor" ] ], "additional_components": [ "DDB_G0278673", "DDB_G0278673", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318" ] }, "reaction_10623328": { "compartment": "compartment_70101", "id": "reaction_10623328", "reactome": "R-DDI-8944454", "name": "mTORC1 phosphorylates MAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623321", "species_113592" ], "products": [ "species_10623326", "species_29370" ], "modifiers": [ [ "species_10584242", "catalyst" ] ], "additional_components": [ "DDB_G0278673", "DDB_G0278673", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318" ] }, "reaction_10616691": { "compartment": "compartment_70101", "id": "reaction_10616691", "reactome": "R-DDI-6807105", "name": "Monoubiquitinated PTEN translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616685" ], "products": [ "species_10616689" ], "modifiers": [], "additional_components": [ "DDB_G0286557", "DDB_G0286557" ] }, "reaction_10616696": { "compartment": "compartment_7660", "id": "reaction_10616696", "reactome": "R-DDI-6807118", "name": "USP7 deubiquitinates monoubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10616689" ], "products": [ "species_10616693", "species_10576865" ], "modifiers": [ [ "species_10602170", "catalyst" ], [ "species_10601869", "inhibitor" ] ], "additional_components": [ "DDB_G0286557", "DDB_G0286557", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0276443", "DDB_G0285989" ] }, "reaction_10616699": { "compartment": "compartment_7660", "id": "reaction_10616699", "reactome": "R-DDI-6807126", "name": "Deubiquitinated PTEN translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616693" ], "products": [ "species_10587224" ], "modifiers": [], "additional_components": [ "DDB_G0286557", "DDB_G0286557" ] }, "reaction_10618691": { "compartment": "compartment_70101", "id": "reaction_10618691", "reactome": "R-DDI-8850992", "name": "Proteasome degrades polyubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618689" ], "products": [ "species_10577037" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q8T9S7", "DDB_G0286557", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10623382": { "compartment": "compartment_70101", "id": "reaction_10623382", "reactome": "R-DDI-8948800", "name": "TNKS and TNKS2 PARylate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587224", "species_29360" ], "products": [ "species_197277", "species_10623370" ], "modifiers": [ [ "species_10623379", "catalyst" ] ], "additional_components": [ "DDB_G0286557", "DDB_G0286557", "Q86J21", "DDB_G0274293" ] }, "reaction_10618679": { "compartment": "compartment_70101", "id": "reaction_10618679", "reactome": "R-DDI-8850945", "name": "Casein kinase II phosphorylates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10587224" ], "products": [ "species_29370", "species_10618677" ], "modifiers": [ [ "species_10601344", "catalyst" ] ], "additional_components": [ "DDB_G0286557", "DDB_G0286557", "Q54PF1", "DDB_G0284601", "Q02720", "DDB_G0276885", "Q54LR6", "DDB_G0286481" ] }, "reaction_10623365": { "compartment": "compartment_70101", "id": "reaction_10623365", "reactome": "R-DDI-8948757", "name": "AKT phosphorylates MKRN1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10596354" ], "products": [ "species_29370", "species_10623363" ], "modifiers": [ [ "species_10586959", "catalyst" ] ], "additional_components": [ "DDB_G0281657", "DDB_G0281657", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795" ] }, "reaction_10616726": { "compartment": "compartment_70101", "id": "reaction_10616726", "reactome": "R-DDI-6807206", "name": "USP13 and OTUD3 deubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616716", "species_29356" ], "products": [ "species_10577037", "species_10587224" ], "modifiers": [ [ "species_10616723", "catalyst" ] ], "additional_components": [ "DDB_G0286557", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0286557", "Q55FY4", "DDB_G0267906", "P54201", "DDB_G0291239" ] }, "reaction_10616713": { "compartment": "compartment_70101", "id": "reaction_10616713", "reactome": "R-DDI-6807134", "name": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10587224" ], "products": [ "species_10616702" ], "modifiers": [ [ "species_10616710", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0286557", "DDB_G0286557", "C7G034", "DDB_G0285063", "Q54QF1", "DDB_G0283983" ] }, "reaction_10623368": { "compartment": "compartment_70101", "id": "reaction_10623368", "reactome": "R-DDI-8948775", "name": "MKRN1 polyubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10587224" ], "products": [ "species_10616716" ], "modifiers": [ [ "species_10623363", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0286557", "DDB_G0286557", "DDB_G0281657" ] }, "reaction_10593296": { "compartment": "compartment_70101", "id": "reaction_10593296", "reactome": "R-DDI-450488", "name": "BRF1 Complex recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593226", "species_10591881", "species_10591977", "species_10593284", "species_10591874" ], "products": [ "species_10593294" ], "modifiers": [], "additional_components": [ "DDB_G0289921", "DDB_G0283315", "Q55BJ2", "DDB_G0271100", "Q54VM4", "DDB_G0280251", "Q54CU6", "DDB_G0292692", "Q55BB0", "DDB_G0271396", "Q54EU6", "DDB_G0291328", "Q54Q83", "DDB_G0284053", "Q54EV5", "DDB_G0291310", "Q54N99", "DDB_G0285377", "Q54BH9", "DDB_G0293614", "Q7KWX9", "DDB_G0276783", "Q54MG5", "DDB_G0285973", "DDB_G0287243", "Q54KM1", "DDB_G0287243", "Q54MG5", "DDB_G0285973", "Q55BJ2", "DDB_G0271100", "Q54VM4", "DDB_G0280251", "Q54CU6", "DDB_G0292692", "Q55BB0", "DDB_G0271396", "Q54EU6", "DDB_G0291328", "Q54Q83", "DDB_G0284053", "Q54EV5", "DDB_G0291310", "Q54N99", "DDB_G0285377", "Q54BH9", "DDB_G0293614", "Q7KWX9", "DDB_G0276783", "Q54R87", "DDB_G0283315", "Q54GU2", "DDB_G0289921" ] }, "reaction_10593303": { "compartment": "compartment_70101", "id": "reaction_10593303", "reactome": "R-DDI-450490", "name": "Protein Kinase B/Akt phosphorylates BRF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10593284" ], "products": [ "species_29370", "species_10593300" ], "modifiers": [ [ "species_10586949", "catalyst" ] ], "additional_components": [ "Q54MG5", "DDB_G0285973", "Q54MG5", "DDB_G0285973", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795" ] }, "reaction_10593305": { "compartment": "compartment_70101", "id": "reaction_10593305", "reactome": "R-DDI-450517", "name": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_450523", "species_10593282" ], "products": [ "species_10593284" ], "modifiers": [], "additional_components": [ "DDB_G0285973", "Q54MG5", "DDB_G0285973" ] }, "reaction_10586026": { "compartment": "compartment_876", "id": "reaction_10586026", "reactome": "R-DDI-189242", "name": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189246" ], "products": [ "species_189219" ], "modifiers": [ [ "species_10586023", "catalyst" ] ], "additional_components": [ "species_70113", "CHEBI:17118", "species_29532", "CHEBI:17118", "species_70113", "species_29532", "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10586015": { "compartment": "compartment_876", "id": "reaction_10586015", "reactome": "R-DDI-189222", "name": "SLC2A5 transports fructose from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189049" ], "products": [ "species_29532" ], "modifiers": [ [ "species_10586012", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10627366": { "compartment": "compartment_70101", "id": "reaction_10627366", "reactome": "R-DDI-9687625", "name": "ATP binds MLKL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10604755" ], "products": [ "species_10627364" ], "modifiers": [], "additional_components": [ "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54TM7", "DDB_G0281557", "species_113592", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417" ] }, "reaction_10627370": { "compartment": "compartment_70101", "id": "reaction_10627370", "reactome": "R-DDI-9687638", "name": "MLKL binds IP4, IP5 and IP6 ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994146", "species_10604761", "species_1629770", "species_994141" ], "products": [ "species_10627368" ], "modifiers": [], "additional_components": [ "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "species_994141", "species_1629770", "species_994146" ] }, "reaction_10611280": { "compartment": "compartment_70101", "id": "reaction_10611280", "reactome": "R-DDI-5692462", "name": "ATP13A1 transports Mn2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29418", "species_113592" ], "products": [ "species_29372", "species_29370", "species_1981162" ], "modifiers": [ [ "species_10611277", "catalyst" ] ], "additional_components": [ "DDB_G0293004" ] }, "reaction_10595064": { "compartment": "compartment_20699", "id": "reaction_10595064", "reactome": "R-DDI-936895", "name": "ATP7B transports cytosolic Cu2+ to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_209799" ], "products": [ "species_29372", "species_936901", "species_29370" ], "modifiers": [ [ "species_10595061", "catalyst" ] ], "additional_components": [ "Q55DN5", "DDB_G0284141", "Q54Q77", "DDB_G0284141", "Q557B5", "DDB_G0284141" ] }, "reaction_10595352": { "compartment": "compartment_70101", "id": "reaction_10595352", "reactome": "R-DDI-947591", "name": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_947588", "species_113592" ], "products": [ "species_29372", "species_29370", "species_947594" ], "modifiers": [ [ "species_10595291", "catalyst" ] ], "additional_components": [ "species_1500646", "species_1500581", "species_1500581", "species_1500646", "Q54U08", "DDB_G0281401", "Q86H52", "DDB_G0286891", "Q551T0", "DDB_G0286891", "Q553A4", "DDB_G0286891", "Q54L55", "DDB_G0286891", "Q55E61", "DDB_G0286891" ] }, "reaction_10611291": { "compartment": "compartment_70101", "id": "reaction_10611291", "reactome": "R-DDI-5692480", "name": "ATP13A2 transports cations from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5692450" ], "products": [ "species_29372", "species_29370", "species_5692484" ], "modifiers": [ [ "species_10611288", "catalyst" ] ], "additional_components": [ "Q54NW5", "DDB_G0284955", "Q54P22", "DDB_G0284955", "Q54X63", "DDB_G0284955" ] }, "reaction_10605018": { "compartment": "compartment_70101", "id": "reaction_10605018", "reactome": "R-DDI-5251989", "name": "ATP13A4,5 transport divalent ions from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5252122", "species_113592" ], "products": [ "species_29372", "species_29370", "species_5252016" ], "modifiers": [ [ "species_10605015", "catalyst" ] ], "additional_components": [ "Q54P22", "DDB_G0284955", "Q54X63", "DDB_G0284955", "Q54NW5", "DDB_G0284955" ] }, "reaction_10600371": { "compartment": "compartment_161320", "id": "reaction_10600371", "reactome": "R-DDI-2130706", "name": "MHC class II antigen processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2213225" ], "products": [ "species_2213226" ], "modifiers": [ [ "species_10600368", "catalyst" ] ], "additional_components": [ "O76856", "DDB_G0279411", "Q54UH2", "DDB_G0282991", "Q23894", "DDB_G0283867", "Q54RQ2", "DDB_G0282991", "Q54UH3", "DDB_G0282991", "Q86KD4", "DDB_G0282991", "P04989", "DDB_G0279799", "Q54TR1", "DDB_G0281605", "P04988", "DDB_G0290957" ] }, "reaction_10605435": { "compartment": "compartment_70101", "id": "reaction_10605435", "reactome": "R-DDI-5578910", "name": "KCNK dimers transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10605432", "catalyst" ] ], "additional_components": [ "Q86K40", "DDB_G0277255", "Q8T268", "DDB_G0277255" ] }, "reaction_10612564": { "compartment": "compartment_1660541", "id": "reaction_10612564", "reactome": "R-DDI-6784729", "name": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612534" ], "products": [ "species_10612562" ], "modifiers": [], "additional_components": [ "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54H39", "DDB_G0289721", "Q54X82", "DDB_G0279141", "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54X82", "DDB_G0279141", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403" ] }, "reaction_10622308": { "compartment": "compartment_161320", "id": "reaction_10622308", "reactome": "R-DDI-8876472", "name": "NPC2 binds CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848047", "species_10622304" ], "products": [ "species_10622306" ], "modifiers": [], "additional_components": [ "Q54SW1", "DDB_G0287185", "Q54MV4", "DDB_G0287185", "Q54SZ8", "DDB_G0287185", "Q54SW2", "DDB_G0287185", "Q54TL9", "DDB_G0287185", "Q54SZ9", "DDB_G0287185", "Q54KP7", "DDB_G0287185", "Q55BL4", "DDB_G0287185", "Q54YD2", "DDB_G0287185", "Q54SW1", "DDB_G0287185", "Q54MV4", "DDB_G0287185", "Q54SZ8", "DDB_G0287185", "Q54SW2", "DDB_G0287185", "Q54TL9", "DDB_G0287185", "Q54SZ9", "DDB_G0287185", "Q54KP7", "DDB_G0287185", "Q55BL4", "DDB_G0287185", "Q54YD2", "DDB_G0287185", "species_216762" ] }, "reaction_10612566": { "compartment": "compartment_1660541", "id": "reaction_10612566", "reactome": "R-DDI-6784738", "name": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612562" ], "products": [ "species_10612560" ], "modifiers": [], "additional_components": [ "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54X82", "DDB_G0279141", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54X82", "DDB_G0279141", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403" ] }, "reaction_10622314": { "compartment": "compartment_161320", "id": "reaction_10622314", "reactome": "R-DDI-8876484", "name": "NPC2 transfers CHOL to NPC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622310", "species_10622306" ], "products": [ "species_10622312", "species_10622304" ], "modifiers": [], "additional_components": [ "DDB_G0269158", "Q54SW1", "DDB_G0287185", "Q54MV4", "DDB_G0287185", "Q54SZ8", "DDB_G0287185", "Q54SW2", "DDB_G0287185", "Q54TL9", "DDB_G0287185", "Q54SZ9", "DDB_G0287185", "Q54KP7", "DDB_G0287185", "Q55BL4", "DDB_G0287185", "Q54YD2", "DDB_G0287185", "species_216762", "Q9TVK6", "DDB_G0269158", "species_216762", "Q54SW1", "DDB_G0287185", "Q54MV4", "DDB_G0287185", "Q54SZ8", "DDB_G0287185", "Q54SW2", "DDB_G0287185", "Q54TL9", "DDB_G0287185", "Q54SZ9", "DDB_G0287185", "Q54KP7", "DDB_G0287185", "Q55BL4", "DDB_G0287185", "Q54YD2", "DDB_G0287185" ] }, "reaction_10617819": { "compartment": "compartment_70101", "id": "reaction_10617819", "reactome": "R-DDI-6813720", "name": "NCEH1 hydrolyzes cholesterol esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_163579" ], "products": [ "species_8876730", "species_216762" ], "modifiers": [ [ "species_10617816", "catalyst" ] ], "additional_components": [ "DDB_G0283819" ] }, "reaction_10622316": { "compartment": "compartment_12045", "id": "reaction_10622316", "reactome": "R-DDI-8876485", "name": "CHOL translocates from lysosome membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622312" ], "products": [ "species_193384", "species_10622310" ], "modifiers": [], "additional_components": [ "Q9TVK6", "DDB_G0269158", "species_216762", "DDB_G0269158" ] }, "reaction_10622364": { "compartment": "compartment_12045", "id": "reaction_10622364", "reactome": "R-DDI-8876696", "name": "SOAT1,2 transfer acyl group to CHOL forming CHEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193384", "species_1500578" ], "products": [ "species_8876704", "species_76194" ], "modifiers": [ [ "species_10622361", "catalyst" ] ], "additional_components": [ "Q551G5", "DDB_G0276523" ] }, "reaction_10619494": { "compartment": "compartment_876", "id": "reaction_10619494", "reactome": "R-DDI-8855130", "name": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619484" ], "products": [ "species_10619492" ], "modifiers": [], "additional_components": [ "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54H39", "DDB_G0289721", "Q54X82", "DDB_G0279141", "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54X82", "DDB_G0279141", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403" ] }, "reaction_10607943": { "compartment": "compartment_70101", "id": "reaction_10607943", "reactome": "R-DDI-5682101", "name": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607908" ], "products": [ "species_29370", "species_10607940" ], "modifiers": [ [ "species_10582991", "catalyst" ] ], "additional_components": [ "Q8T6J5", "DDB_G0267438", "Q54BT5", "DDB_G0293436", "Q555Z5", "DDB_G0274121", "Q55BC0", "DDB_G0271138", "Q8T5Z7", "DDB_G0291994", "Q8T6J1", "DDB_G0291245", "Q8T6J2", "DDB_G0274119", "Q55BC0", "DDB_G0271138", "Q8T6J5", "DDB_G0267438", "Q8T5Z7", "DDB_G0291994", "Q54BT5", "DDB_G0293436", "Q8T6J1", "DDB_G0291245", "Q555Z5", "DDB_G0274121", "Q8T6J2", "DDB_G0274119", "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029" ] }, "reaction_10607945": { "compartment": "compartment_12045", "id": "reaction_10607945", "reactome": "R-DDI-5682103", "name": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607890" ], "products": [ "species_10607908" ], "modifiers": [], "additional_components": [ "Q555Z5", "DDB_G0274121", "Q8T6J1", "DDB_G0291245", "Q55BC0", "DDB_G0271138", "Q8T6J2", "DDB_G0274119", "Q54BT5", "DDB_G0293436", "Q8T5Z7", "DDB_G0291994", "Q8T6J5", "DDB_G0267438", "Q8T6J5", "DDB_G0267438", "Q54BT5", "DDB_G0293436", "Q555Z5", "DDB_G0274121", "Q55BC0", "DDB_G0271138", "Q8T5Z7", "DDB_G0291994", "Q8T6J1", "DDB_G0291245", "Q8T6J2", "DDB_G0274119" ] }, "reaction_10620000": { "compartment": "compartment_70616", "id": "reaction_10620000", "reactome": "R-DDI-8867344", "name": "OMA1 hydrolyses OPA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619980", "species_113521" ], "products": [ "species_10619992", "species_10619986" ], "modifiers": [ [ "species_10619997", "catalyst" ] ], "additional_components": [ "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "DDB_G0289335" ] }, "reaction_10604720": { "compartment": "compartment_70101", "id": "reaction_10604720", "reactome": "R-DDI-5213464", "name": "RIPK1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10604713" ], "products": [ "species_10604715", "species_29370" ], "modifiers": [ [ "species_10604713", "catalyst" ], [ "species_10604718", "inhibitor" ] ], "additional_components": [ "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417" ] }, "reaction_10604723": { "compartment": "compartment_70101", "id": "reaction_10604723", "reactome": "R-DDI-5213466", "name": "RIPK3 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604715", "species_113592" ], "products": [ "species_10602348", "species_29370" ], "modifiers": [ [ "species_10604713", "catalyst" ], [ "species_10604718", "inhibitor" ] ], "additional_components": [ "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417" ] }, "reaction_10604757": { "compartment": "compartment_70101", "id": "reaction_10604757", "reactome": "R-DDI-5218891", "name": "RIPK1:RIPK3 oligomer binds MLKL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602350", "species_10604753" ], "products": [ "species_10604755" ], "modifiers": [], "additional_components": [ "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "DDB_G0281557", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417" ] }, "reaction_10604759": { "compartment": "compartment_70101", "id": "reaction_10604759", "reactome": "R-DDI-5218905", "name": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602348" ], "products": [ "species_10602350" ], "modifiers": [], "additional_components": [ "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417" ] }, "reaction_10605782": { "compartment": "compartment_876", "id": "reaction_10605782", "reactome": "R-DDI-5620975", "name": "MLKL binds PIPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5620974", "species_10602358" ], "products": [ "species_10605771" ], "modifiers": [ [ "species_10605780", "inhibitor" ] ], "additional_components": [ "species_179838", "species_1806180", "species_179856", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "species_179838", "species_1806180", "species_179856", "Q8T7K0", "DDB_G0275451", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417" ] }, "reaction_10604764": { "compartment": "compartment_70101", "id": "reaction_10604764", "reactome": "R-DDI-5218906", "name": "RIPK3 phosphorylates MLKL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10604755" ], "products": [ "species_29370", "species_10604761" ], "modifiers": [ [ "species_10604755", "catalyst" ] ], "additional_components": [ "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417" ] }, "reaction_10600860": { "compartment": "compartment_70101", "id": "reaction_10600860", "reactome": "R-DDI-2317332", "name": "PIP3 recruits AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10590487" ], "products": [ "species_10587009" ], "modifiers": [], "additional_components": [ "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_179838", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795" ] }, "reaction_10625796": { "compartment": "compartment_17951", "id": "reaction_10625796", "reactome": "R-DDI-9033520", "name": "TYSND1 cleaves TYSND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_10625726" ], "products": [ "species_10625791", "species_10625793" ], "modifiers": [ [ "species_10625726", "catalyst" ] ], "additional_components": [ "DDB_G0279049", "DDB_G0279049", "DDB_G0279049", "DDB_G0279049" ] }, "reaction_10589960": { "compartment": "compartment_70101", "id": "reaction_10589960", "reactome": "R-DDI-380930", "name": "Phosphorylated AMPK binds AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587326", "species_76577" ], "products": [ "species_10589958" ], "modifiers": [], "additional_components": [ "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643" ] }, "reaction_10592925": { "compartment": "compartment_876", "id": "reaction_10592925", "reactome": "R-DDI-447074", "name": "AMPK phosphorylates Raptor in the mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10584242" ], "products": [ "species_29370", "species_10584309" ], "modifiers": [ [ "species_10589958", "catalyst" ] ], "additional_components": [ "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643" ] }, "reaction_10606321": { "compartment": "compartment_70101", "id": "reaction_10606321", "reactome": "R-DDI-5653957", "name": "Rag dimer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584219", "species_10584232" ], "products": [ "species_10584234" ], "modifiers": [], "additional_components": [ "Q54IK1", "DDB_G0288701", "species_29438", "Q54PK6", "DDB_G0284495", "species_29420", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438" ] }, "reaction_10623826": { "compartment": "compartment_70101", "id": "reaction_10623826", "reactome": "R-DDI-8952726", "name": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428011" ], "products": [ "species_29468" ], "modifiers": [ [ "species_10584238", "catalyst" ] ], "additional_components": [ "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567" ] }, "reaction_10584160": { "compartment": "compartment_17938", "id": "reaction_10584160", "reactome": "R-DDI-165195", "name": "GTP loading by Rheb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10584156" ], "products": [ "species_10584158", "species_29420" ], "modifiers": [], "additional_components": [ "Q54DD9", "DDB_G0292318", "species_29420", "Q54DD9", "DDB_G0292318", "species_29438" ] }, "reaction_10606323": { "compartment": "compartment_17938", "id": "reaction_10606323", "reactome": "R-DDI-5653968", "name": "Ragulator:Rag dimers:SLC38A9 bind mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584238", "species_10584177" ], "products": [ "species_10584240" ], "modifiers": [], "additional_components": [ "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567" ] }, "reaction_10589778": { "compartment": "compartment_17938", "id": "reaction_10589778", "reactome": "R-DDI-377186", "name": "Activated Akt1 phosphorylates AKT1S1 (PRAS40)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10584263" ], "products": [ "species_10584255", "species_29370" ], "modifiers": [ [ "species_10587569", "catalyst" ] ], "additional_components": [ "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795" ] }, "reaction_10606325": { "compartment": "compartment_70101", "id": "reaction_10606325", "reactome": "R-DDI-5653974", "name": "Ragulator binds Rag dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584206", "species_10584234" ], "products": [ "species_10584236" ], "modifiers": [], "additional_components": [ "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567" ] }, "reaction_10584244": { "compartment": "compartment_70101", "id": "reaction_10584244", "reactome": "R-DDI-165680", "name": "Formation of active mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584158", "species_10584240" ], "products": [ "species_10584242" ], "modifiers": [], "additional_components": [ "Q54DD9", "DDB_G0292318", "species_29438", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318" ] }, "reaction_10584272": { "compartment": "compartment_17938", "id": "reaction_10584272", "reactome": "R-DDI-165692", "name": "Phosphorylation of 4E-BP1 by activated mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580061", "species_113592" ], "products": [ "species_10584250", "species_29370" ], "modifiers": [ [ "species_10584242", "catalyst" ], [ "species_10584259", "catalyst" ], [ "species_10584263", "inhibitor" ], [ "species_10584270", "inhibitor" ] ], "additional_components": [ "Q55FE0", "DDB_G0268574", "Q54DU8", "DDB_G0291990", "Q55FE0", "DDB_G0268574", "Q54DU8", "DDB_G0291990", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54UR2", "DDB_G0280877" ] }, "reaction_10584339": { "compartment": "compartment_70101", "id": "reaction_10584339", "reactome": "R-DDI-165766", "name": "Phosphorylation and activation of eIF4G by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580029", "species_113592" ], "products": [ "species_29370", "species_10584337" ], "modifiers": [ [ "species_10584299", "catalyst" ] ], "additional_components": [ "DDB_G0275395", "DDB_G0275395", "P34102", "DDB_G0286125", "Q8MYF1", "DDB_G0277449" ] }, "reaction_10627344": { "compartment": "compartment_70101", "id": "reaction_10627344", "reactome": "R-DDI-9679044", "name": "FKBP1A binds sirolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584268", "species_9678687" ], "products": [ "species_10584270" ], "modifiers": [], "additional_components": [ "DDB_G0280877", "Q54UR2", "DDB_G0280877" ] }, "reaction_10584322": { "compartment": "compartment_70101", "id": "reaction_10584322", "reactome": "R-DDI-165726", "name": "Phosphorylation of Ribosomal protein S6 by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10579877" ], "products": [ "species_10584319", "species_29370" ], "modifiers": [ [ "species_10584299", "catalyst" ] ], "additional_components": [ "DDB_G0280823", "DDB_G0280823", "P34102", "DDB_G0286125", "Q8MYF1", "DDB_G0277449" ] }, "reaction_10584277": { "compartment": "compartment_70101", "id": "reaction_10584277", "reactome": "R-DDI-165708", "name": "Dissociation of phosphorylated 4EBP1 from eIF4E", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584250" ], "products": [ "species_10584248", "species_10580024" ], "modifiers": [], "additional_components": [ "Q55FE0", "DDB_G0268574", "Q54DU8", "DDB_G0291990", "DDB_G0291990", "DDB_G0268574" ] }, "reaction_10584311": { "compartment": "compartment_17938", "id": "reaction_10584311", "reactome": "R-DDI-165718", "name": "mTORC1 phosphorylation of RPS6KB1 (S6K)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10584289" ], "products": [ "species_10584299", "species_29370" ], "modifiers": [ [ "species_10584242", "catalyst" ], [ "species_10584259", "catalyst" ], [ "species_10584309", "inhibitor" ], [ "species_10584270", "inhibitor" ] ], "additional_components": [ "P34102", "DDB_G0286125", "Q8MYF1", "DDB_G0277449", "P34102", "DDB_G0286125", "Q8MYF1", "DDB_G0277449", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54UR2", "DDB_G0280877" ] }, "reaction_10584344": { "compartment": "compartment_70101", "id": "reaction_10584344", "reactome": "R-DDI-165777", "name": "Phosphorylation and activation of eIF4B by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10580036" ], "products": [ "species_29370", "species_10584342" ], "modifiers": [ [ "species_10584299", "catalyst" ] ], "additional_components": [ "DDB_G0275459", "DDB_G0275459", "P34102", "DDB_G0286125", "Q8MYF1", "DDB_G0277449" ] }, "reaction_10584332": { "compartment": "compartment_70101", "id": "reaction_10584332", "reactome": "R-DDI-165758", "name": "Phosphorylation and inactivation of eEF2K by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10584327" ], "products": [ "species_10584330", "species_29370" ], "modifiers": [ [ "species_10584299", "catalyst" ] ], "additional_components": [ "DDB_G0282489", "DDB_G0282489", "P34102", "DDB_G0286125", "Q8MYF1", "DDB_G0277449" ] }, "reaction_10606859": { "compartment": "compartment_17938", "id": "reaction_10606859", "reactome": "R-DDI-5672828", "name": "mTORC1 phosphorylates AKT1S1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10584259" ], "products": [ "species_29370", "species_10606856" ], "modifiers": [ [ "species_10584259", "catalyst" ] ], "additional_components": [ "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318" ] }, "reaction_10606319": { "compartment": "compartment_17938", "id": "reaction_10606319", "reactome": "R-DDI-5653936", "name": "Formation of Ragulator complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584204", "species_10584189", "species_10584184", "species_10584199", "species_10584194" ], "products": [ "species_10584206" ], "modifiers": [], "additional_components": [ "DDB_G0283567", "DDB_G0291091", "DDB_G0292160", "DDB_G0291948", "DDB_G0274833", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567" ] }, "reaction_10605537": { "compartment": "compartment_70101", "id": "reaction_10605537", "reactome": "R-DDI-5615668", "name": "AKR1C3 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_975622", "species_29364" ], "products": [ "species_29366", "species_975599" ], "modifiers": [ [ "species_10586594", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10605363": { "compartment": "compartment_70101", "id": "reaction_10605363", "reactome": "R-DDI-5362564", "name": "ADH1A,1C,4 oxidise atROL to atRAL in vitro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975599", "species_29360" ], "products": [ "species_70106", "species_975622", "species_73473" ], "modifiers": [ [ "species_10605360", "catalyst" ] ], "additional_components": [ "species_29426", "Q54TC2", "DDB_G0281865" ] }, "reaction_10611912": { "compartment": "compartment_70101", "id": "reaction_10611912", "reactome": "R-DDI-5696101", "name": "ALDH8A1 oxidises 9cRAL to 9cRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5362565", "species_29360" ], "products": [ "species_70106", "species_5362520", "species_73473" ], "modifiers": [ [ "species_10611909", "catalyst" ] ], "additional_components": [ "DDB_G0283943" ] }, "reaction_10605371": { "compartment": "compartment_70101", "id": "reaction_10605371", "reactome": "R-DDI-5419165", "name": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_975622", "species_29364" ], "products": [ "species_29366", "species_975599" ], "modifiers": [ [ "species_10605368", "catalyst" ] ], "additional_components": [ "DDB_G0293604" ] }, "reaction_10605791": { "compartment": "compartment_70616", "id": "reaction_10605791", "reactome": "R-DDI-5623643", "name": "RDH13 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5623644", "species_5623648", "species_163953" ], "products": [ "species_5623650", "species_5623649" ], "modifiers": [ [ "species_10605788", "catalyst" ] ], "additional_components": [ "DDB_G0286575" ] }, "reaction_10605358": { "compartment": "compartment_70101", "id": "reaction_10605358", "reactome": "R-DDI-5362522", "name": "ALDHs oxidise atRAL to atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_975622", "species_29360" ], "products": [ "species_70106", "species_5334816", "species_73473" ], "modifiers": [ [ "species_10605355", "catalyst" ] ], "additional_components": [ "Q54IU0", "DDB_G0288521" ] }, "reaction_10624618": { "compartment": "compartment_7660", "id": "reaction_10624618", "reactome": "R-DDI-9012319", "name": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10624613" ], "products": [ "species_113582", "species_10624615" ], "modifiers": [ [ "species_10624613", "catalyst" ] ], "additional_components": [ "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "species_1254400", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "species_1254400", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "species_1254400", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10623125": { "compartment": "compartment_7660", "id": "reaction_10623125", "reactome": "R-DDI-8939204", "name": "ESTG binds ESR1:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623113", "species_1254400" ], "products": [ "species_10623115" ], "modifiers": [], "additional_components": [ "Q54WQ9", "DDB_G0279491", "P54651", "DDB_G0267400", "species_113592", "Q55FM3", "DDB_G0268042", "species_1254400", "Q54WQ9", "DDB_G0279491", "P54651", "DDB_G0267400", "species_113592", "Q55FM3", "DDB_G0268042" ] }, "reaction_10627482": { "compartment": "compartment_7660", "id": "reaction_10627482", "reactome": "R-DDI-9709547", "name": "ESTG binds ESR2:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623119", "species_1254400" ], "products": [ "species_10623121" ], "modifiers": [], "additional_components": [ "Q54WQ9", "DDB_G0279491", "P54651", "DDB_G0267400", "species_113592", "Q55FM3", "DDB_G0268042", "species_1254400", "Q54WQ9", "DDB_G0279491", "P54651", "DDB_G0267400", "species_113592", "Q55FM3", "DDB_G0268042" ] }, "reaction_10598291": { "compartment": "compartment_70101", "id": "reaction_10598291", "reactome": "R-DDI-1504190", "name": "DVL is ubiquitinated by CUL3:KLHL12:RBX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598284", "species_10577037" ], "products": [ "species_10598288" ], "modifiers": [ [ "species_10598284", "catalyst" ] ], "additional_components": [ "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903", "Q55BF8", "DDB_G0271372", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903", "Q55BF8", "DDB_G0271372", "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903", "Q55BF8", "DDB_G0271372" ] }, "reaction_10598293": { "compartment": "compartment_70101", "id": "reaction_10598293", "reactome": "R-DDI-1504193", "name": "Ubiquitinated DVL is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598288" ], "products": [ "species_10577037", "species_10598280" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903", "Q55BF8", "DDB_G0271372", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903", "Q55BF8", "DDB_G0271372", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10602277": { "compartment": "compartment_20699", "id": "reaction_10602277", "reactome": "R-DDI-3247836", "name": "Retromer recycles WLS to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602271" ], "products": [ "species_10602275" ], "modifiers": [], "additional_components": [ "Q54C24", "DDB_G0293218", "Q55CA0", "DDB_G0269168", "Q54IF7", "DDB_G0288787", "Q54UN7", "DDB_G0280921", "Q54C24", "DDB_G0293218", "Q55CA0", "DDB_G0269168", "Q54IF7", "DDB_G0288787", "Q54UN7", "DDB_G0280921" ] }, "reaction_10600819": { "compartment": "compartment_70101", "id": "reaction_10600819", "reactome": "R-DDI-2219524", "name": "PDPK1 binds PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587607", "species_179856" ], "products": [ "species_10600817" ], "modifiers": [], "additional_components": [ "DDB_G0281471", "species_179856", "Q54TW2", "DDB_G0281471" ] }, "reaction_10596961": { "compartment": "compartment_70101", "id": "reaction_10596961", "reactome": "R-DDI-1011598", "name": "DOCKs bind to RhoGEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596957", "species_10590248" ], "products": [ "species_10596959" ], "modifiers": [], "additional_components": [ "Q54CA8", "DDB_G0293084", "Q554I8", "DDB_G0293084", "Q55EI2", "DDB_G0293084", "Q86I66", "DDB_G0293084", "Q54PB7", "DDB_G0292004", "Q55BQ8", "DDB_G0292004", "Q54DS6", "DDB_G0291974", "Q54DW1", "DDB_G0292004", "DDB_G0277869", "P34144", "DDB_G0277869", "Q54CA8", "DDB_G0293084", "Q554I8", "DDB_G0293084", "Q55EI2", "DDB_G0293084", "Q86I66", "DDB_G0293084", "Q54PB7", "DDB_G0292004", "Q55BQ8", "DDB_G0292004", "Q54DS6", "DDB_G0291974", "Q54DW1", "DDB_G0292004" ] }, "reaction_10596720": { "compartment": "compartment_70101", "id": "reaction_10596720", "reactome": "R-DDI-984689", "name": "Kinesin-7 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596682" ], "products": [ "species_10596684" ], "modifiers": [], "additional_components": [ "DDB_G0285101", "Q54NP8", "DDB_G0285101" ] }, "reaction_10596718": { "compartment": "compartment_70101", "id": "reaction_10596718", "reactome": "R-DDI-984606", "name": "Kinesin-5 is a homotetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596668" ], "products": [ "species_10596670" ], "modifiers": [], "additional_components": [ "DDB_G0288361", "Q6RZZ9", "DDB_G0288361" ] }, "reaction_10596740": { "compartment": "compartment_7660", "id": "reaction_10596740", "reactome": "R-DDI-994106", "name": "HP1 alpha binds Histone H3K9(me)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596728", "species_10596736" ], "products": [ "species_10596738" ], "modifiers": [], "additional_components": [ "Q54RN0", "DDB_G0283023", "Q54RQ4", "DDB_G0283023", "Q55C69", "DDB_G0270198", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q54RN0", "DDB_G0283023", "Q54RQ4", "DDB_G0283023", "Q55C69", "DDB_G0270198" ] }, "reaction_10596807": { "compartment": "compartment_70101", "id": "reaction_10596807", "reactome": "R-DDI-994148", "name": "LRRC16A binds F-actin capping protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594244", "species_10596803" ], "products": [ "species_10596805" ], "modifiers": [], "additional_components": [ "P13021", "DDB_G0267374", "P13022", "DDB_G0272104", "Q95VZ3", "DDB_G0292386", "Q54LE3", "DDB_G0293920", "Q54SR9", "DDB_G0293920", "Q54B43", "DDB_G0293920", "Q54YK2", "DDB_G0293920", "Q54B76", "DDB_G0293920", "Q54MF0", "DDB_G0293920", "Q54NS2", "DDB_G0293920", "Q7KWW4", "DDB_G0293920", "Q54G18", "DDB_G0290439", "Q95VZ3", "DDB_G0292386", "Q54LE3", "DDB_G0293920", "Q54SR9", "DDB_G0293920", "Q54B43", "DDB_G0293920", "Q54YK2", "DDB_G0293920", "Q54B76", "DDB_G0293920", "Q54MF0", "DDB_G0293920", "Q54NS2", "DDB_G0293920", "Q7KWW4", "DDB_G0293920", "Q54G18", "DDB_G0290439", "P13021", "DDB_G0267374", "P13022", "DDB_G0272104" ] }, "reaction_10600822": { "compartment": "compartment_70101", "id": "reaction_10600822", "reactome": "R-DDI-2267372", "name": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994123" ], "products": [ "species_994146", "species_29370" ], "modifiers": [ [ "species_10596745", "catalyst" ] ], "additional_components": [ "DDB_G0269746" ] }, "reaction_10594246": { "compartment": "compartment_70101", "id": "reaction_10594246", "reactome": "R-DDI-879459", "name": "F-actin capping protein is a heterodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594237", "species_10594242" ], "products": [ "species_10594244" ], "modifiers": [], "additional_components": [ "DDB_G0272104", "DDB_G0267374", "P13021", "DDB_G0267374", "P13022", "DDB_G0272104" ] }, "reaction_10619768": { "compartment": "compartment_70101", "id": "reaction_10619768", "reactome": "R-DDI-8865107", "name": "MICAL1 produces NADP+, H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29364" ], "products": [ "species_29366", "species_29408" ], "modifiers": [ [ "species_10619765", "catalyst" ] ], "additional_components": [ "Q54FV6", "DDB_G0293708", "Q54BL7", "DDB_G0293708", "species_113596" ] }, "reaction_10596826": { "compartment": "compartment_5460", "id": "reaction_10596826", "reactome": "R-DDI-1008248", "name": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159448", "species_113573" ], "products": [ "species_113581", "species_113525" ], "modifiers": [ [ "species_10596823", "catalyst" ] ], "additional_components": [ "DDB_G0292730" ] }, "reaction_10596748": { "compartment": "compartment_70101", "id": "reaction_10596748", "reactome": "R-DDI-994137", "name": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994149", "species_113592" ], "products": [ "species_29370", "species_994141" ], "modifiers": [ [ "species_10596745", "catalyst" ] ], "additional_components": [ "DDB_G0269746" ] }, "reaction_10596751": { "compartment": "compartment_70101", "id": "reaction_10596751", "reactome": "R-DDI-994140", "name": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994123" ], "products": [ "species_29370", "species_994170" ], "modifiers": [ [ "species_10596745", "catalyst" ] ], "additional_components": [ "DDB_G0269746" ] }, "reaction_10587611": { "compartment": "compartment_70101", "id": "reaction_10587611", "reactome": "R-DDI-202164", "name": "Translocation of PDK1 to Plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587607", "species_202277" ], "products": [ "species_10587609" ], "modifiers": [], "additional_components": [ "DDB_G0281471", "species_1806238", "species_179838", "species_1806238", "species_179838", "Q54TW2", "DDB_G0281471" ] }, "reaction_10626100": { "compartment": "compartment_70101", "id": "reaction_10626100", "reactome": "R-DDI-9609921", "name": "SGTA binds Tail-anchored protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626061", "species_10626096" ], "products": [ "species_10626098" ], "modifiers": [], "additional_components": [ "Q54VG4", "DDB_G0280345", "Q553P6", "DDB_G0275381", "Q86L22", "DDB_G0277079", "Q54XT7", "DDB_G0278753", "Q54ZH1", "DDB_G0277565", "Q54HM5", "DDB_G0289379", "Q54DG1", "DDB_G0292270", "Q54YR4", "DDB_G0278117", "Q54LP7", "DDB_G0286511", "Q54XS7", "DDB_G0278773", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54JV6", "DDB_G0287777", "Q553P6", "DDB_G0275381", "Q86L22", "DDB_G0277079", "Q54XT7", "DDB_G0278753", "Q54ZH1", "DDB_G0277565", "Q54HM5", "DDB_G0289379", "Q54DG1", "DDB_G0292270", "Q54YR4", "DDB_G0278117", "Q54LP7", "DDB_G0286511", "Q54XS7", "DDB_G0278773", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54JV6", "DDB_G0287777", "Q54VG4", "DDB_G0280345" ] }, "reaction_10626164": { "compartment": "compartment_70101", "id": "reaction_10626164", "reactome": "R-DDI-9617595", "name": "SGTA binds mislocalized membrane protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626061", "species_10626092" ], "products": [ "species_10626162" ], "modifiers": [], "additional_components": [ "Q54VG4", "DDB_G0280345", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54VG4", "DDB_G0280345" ] }, "reaction_10625730": { "compartment": "compartment_17947", "id": "reaction_10625730", "reactome": "R-DDI-9033235", "name": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625710" ], "products": [ "species_10623900", "species_10625728" ], "modifiers": [], "additional_components": [ "Q556W1", "DDB_G0273291", "Q54E41", "DDB_G0291814", "Q75JR2", "DDB_G0272210", "Q54XC3", "DDB_G0279049", "Q54US8", "DDB_G0280851", "Q54GT6", "DDB_G0289923", "Q54QI7", "DDB_G0283813", "Q54GK8", "DDB_G0290089", "Q54GQ6", "DDB_G0289993", "Q54XZ0", "DDB_G0277911", "Q7KWR0", "DDB_G0276281", "Q8MMS1", "DDB_G0277477", "Q54T91", "DDB_G0281917", "Q5FXM5", "DDB_G0270658", "Q54SS0", "DDB_G0282261", "Q54GC2", "DDB_G0290277", "Q54JQ2", "DDB_G0287851", "Q55CT1", "DDB_G0269912", "O77229", "DDB_G0274595", "Q54FR4", "DDB_G0290631", "Q54DA9", "DDB_G0292402", "Q54MD1", "DDB_G0286033", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54MD1", "DDB_G0286033", "Q54GT6", "DDB_G0289923", "Q5FXM5", "DDB_G0270658", "Q54GQ6", "DDB_G0289993", "Q54DA9", "DDB_G0292402", "Q8MMS1", "DDB_G0277477", "Q54E41", "DDB_G0291814", "Q54GC2", "DDB_G0290277", "Q75JR2", "DDB_G0272210", "Q54US8", "DDB_G0280851", "Q54T91", "DDB_G0281917", "Q54SS0", "DDB_G0282261", "O77229", "DDB_G0274595", "Q7KWR0", "DDB_G0276281", "Q54QI7", "DDB_G0283813", "Q55CT1", "DDB_G0269912", "Q556W1", "DDB_G0273291", "Q54JQ2", "DDB_G0287851", "Q54XZ0", "DDB_G0277911", "Q54XC3", "DDB_G0279049", "Q54GK8", "DDB_G0290089", "Q54FR4", "DDB_G0290631" ] }, "reaction_10625798": { "compartment": "compartment_17947", "id": "reaction_10625798", "reactome": "R-DDI-9033527", "name": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623902", "species_10625736" ], "products": [ "species_10625738" ], "modifiers": [], "additional_components": [ "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54WA3", "DDB_G0279801", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54MD1", "DDB_G0286033", "Q54WA3", "DDB_G0279801", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54MD1", "DDB_G0286033", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765" ] }, "reaction_10625732": { "compartment": "compartment_17947", "id": "reaction_10625732", "reactome": "R-DDI-9033236", "name": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625708", "species_10625706" ], "products": [ "species_10625710" ], "modifiers": [], "additional_components": [ "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q556W1", "DDB_G0273291", "Q54E41", "DDB_G0291814", "Q75JR2", "DDB_G0272210", "Q54XC3", "DDB_G0279049", "Q54US8", "DDB_G0280851", "Q54GT6", "DDB_G0289923", "Q54QI7", "DDB_G0283813", "Q54GK8", "DDB_G0290089", "Q54GQ6", "DDB_G0289993", "Q54XZ0", "DDB_G0277911", "Q7KWR0", "DDB_G0276281", "Q8MMS1", "DDB_G0277477", "Q54T91", "DDB_G0281917", "Q5FXM5", "DDB_G0270658", "Q54SS0", "DDB_G0282261", "Q54GC2", "DDB_G0290277", "Q54JQ2", "DDB_G0287851", "Q55CT1", "DDB_G0269912", "O77229", "DDB_G0274595", "Q54FR4", "DDB_G0290631", "Q54DA9", "DDB_G0292402", "Q54MD1", "DDB_G0286033", "Q556W1", "DDB_G0273291", "Q54E41", "DDB_G0291814", "Q75JR2", "DDB_G0272210", "Q54XC3", "DDB_G0279049", "Q54US8", "DDB_G0280851", "Q54GT6", "DDB_G0289923", "Q54QI7", "DDB_G0283813", "Q54GK8", "DDB_G0290089", "Q54GQ6", "DDB_G0289993", "Q54XZ0", "DDB_G0277911", "Q7KWR0", "DDB_G0276281", "Q8MMS1", "DDB_G0277477", "Q54T91", "DDB_G0281917", "Q5FXM5", "DDB_G0270658", "Q54SS0", "DDB_G0282261", "Q54GC2", "DDB_G0290277", "Q54JQ2", "DDB_G0287851", "Q55CT1", "DDB_G0269912", "O77229", "DDB_G0274595", "Q54FR4", "DDB_G0290631", "Q54DA9", "DDB_G0292402", "Q54MD1", "DDB_G0286033", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523" ] }, "reaction_10625643": { "compartment": "compartment_70101", "id": "reaction_10625643", "reactome": "R-DDI-9033232", "name": "PEX7 binds cargo proteins containing PTS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625628", "species_10625639" ], "products": [ "species_10625641" ], "modifiers": [], "additional_components": [ "DDB_G0279801", "O96759", "DDB_G0286183", "Q54SF6", "DDB_G0282495", "Q86IY4", "DDB_G0274339", "O96759", "DDB_G0286183", "Q54SF6", "DDB_G0282495", "Q86IY4", "DDB_G0274339", "Q54WA3", "DDB_G0279801" ] }, "reaction_10625752": { "compartment": "compartment_70101", "id": "reaction_10625752", "reactome": "R-DDI-9033491", "name": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10625749" ], "products": [ "species_10619197", "species_10577037", "species_10625704" ], "modifiers": [ [ "species_10625749", "catalyst" ] ], "additional_components": [ "Q54MD1", "DDB_G0286033", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q553T4", "DDB_G0275415", "DDB_G0275415", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0286033", "Q54MD1", "DDB_G0286033", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q553T4", "DDB_G0275415" ] }, "reaction_10625743": { "compartment": "compartment_17947", "id": "reaction_10625743", "reactome": "R-DDI-9033485", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625738" ], "products": [ "species_10625740", "species_10577361" ], "modifiers": [ [ "species_10625738", "catalyst" ] ], "additional_components": [ "Q54WA3", "DDB_G0279801", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54MD1", "DDB_G0286033", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54WA3", "DDB_G0279801", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54MD1", "DDB_G0286033", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54WA3", "DDB_G0279801", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54MD1", "DDB_G0286033", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765" ] }, "reaction_10625775": { "compartment": "compartment_70101", "id": "reaction_10625775", "reactome": "R-DDI-9033509", "name": "USP9X binds Ub:PEX5L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619197", "species_10625747" ], "products": [ "species_10625749" ], "modifiers": [], "additional_components": [ "DDB_G0275415", "Q54MD1", "DDB_G0286033", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54MD1", "DDB_G0286033", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q553T4", "DDB_G0275415" ] }, "reaction_10625789": { "compartment": "compartment_17947", "id": "reaction_10625789", "reactome": "R-DDI-9033514", "name": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625779" ], "products": [ "species_10625736", "species_10625787" ], "modifiers": [], "additional_components": [ "Q54MD1", "DDB_G0286033", "O96759", "DDB_G0286183", "Q54SF6", "DDB_G0282495", "Q86IY4", "DDB_G0274339", "Q54WA3", "DDB_G0279801", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54WA3", "DDB_G0279801", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54MD1", "DDB_G0286033", "O96759", "DDB_G0286183", "Q86IY4", "DDB_G0274339", "Q54SF6", "DDB_G0282495" ] }, "reaction_10625927": { "compartment": "compartment_17947", "id": "reaction_10625927", "reactome": "R-DDI-9603775", "name": "PEX3:PEX19:class I PMP dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625899" ], "products": [ "species_10625925", "species_10590211", "species_10590227" ], "modifiers": [], "additional_components": [ "Q54U86", "DDB_G0281213", "Q555I0", "DDB_G0274873", "Q54ZX5", "DDB_G0290631", "Q54FR4", "DDB_G0290631", "Q54GD8", "DDB_G0290631", "Q54XX9", "DDB_G0290631", "Q8T8P3", "DDB_G0293194", "Q54N40", "DDB_G0285523", "Q55FL0", "DDB_G0268564", "Q54VX0", "DDB_G0280367", "Q86AC7", "DDB_G0276913", "Q54H86", "DDB_G0289623", "Q54DG1", "DDB_G0292270", "Q54C55", "DDB_G0293264", "Q54CL3", "DDB_G0292870", "Q76P23", "DDB_G0272346", "Q1ZXK7", "DDB_G0276169", "Q550G0", "DDB_G0277113", "Q86AC7", "DDB_G0276913", "Q54H86", "DDB_G0289623", "Q8T8P3", "DDB_G0293194", "Q54CL3", "DDB_G0292870", "Q550G0", "DDB_G0277113", "Q54N40", "DDB_G0285523", "Q54C55", "DDB_G0293264", "Q54DG1", "DDB_G0292270", "Q54FR4", "DDB_G0290631", "Q54XX9", "DDB_G0290631", "Q54GD8", "DDB_G0290631", "Q54ZX5", "DDB_G0290631", "Q76P23", "DDB_G0272346", "Q54VX0", "DDB_G0280367", "Q1ZXK7", "DDB_G0276169", "Q55FL0", "DDB_G0268564", "DDB_G0281213", "DDB_G0274873" ] }, "reaction_10625931": { "compartment": "compartment_70101", "id": "reaction_10625931", "reactome": "R-DDI-9603804", "name": "PEX19 binds class I peroxisomal membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625895", "species_10590227" ], "products": [ "species_10625897" ], "modifiers": [], "additional_components": [ "Q54ZX5", "DDB_G0290631", "Q54FR4", "DDB_G0290631", "Q54GD8", "DDB_G0290631", "Q54XX9", "DDB_G0290631", "Q8T8P3", "DDB_G0293194", "Q54N40", "DDB_G0285523", "Q55FL0", "DDB_G0268564", "Q54VX0", "DDB_G0280367", "Q86AC7", "DDB_G0276913", "Q54H86", "DDB_G0289623", "Q54DG1", "DDB_G0292270", "Q54C55", "DDB_G0293264", "Q54CL3", "DDB_G0292870", "Q76P23", "DDB_G0272346", "Q1ZXK7", "DDB_G0276169", "Q550G0", "DDB_G0277113", "DDB_G0274873", "Q555I0", "DDB_G0274873", "Q54ZX5", "DDB_G0290631", "Q54FR4", "DDB_G0290631", "Q54GD8", "DDB_G0290631", "Q54XX9", "DDB_G0290631", "Q8T8P3", "DDB_G0293194", "Q54N40", "DDB_G0285523", "Q55FL0", "DDB_G0268564", "Q54VX0", "DDB_G0280367", "Q86AC7", "DDB_G0276913", "Q54H86", "DDB_G0289623", "Q54DG1", "DDB_G0292270", "Q54C55", "DDB_G0293264", "Q54CL3", "DDB_G0292870", "Q76P23", "DDB_G0272346", "Q1ZXK7", "DDB_G0276169", "Q550G0", "DDB_G0277113" ] }, "reaction_10625929": { "compartment": "compartment_17947", "id": "reaction_10625929", "reactome": "R-DDI-9603784", "name": "PEX19:class I PMP binds PEX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625897", "species_10590211" ], "products": [ "species_10625899" ], "modifiers": [], "additional_components": [ "Q555I0", "DDB_G0274873", "Q54ZX5", "DDB_G0290631", "Q54FR4", "DDB_G0290631", "Q54GD8", "DDB_G0290631", "Q54XX9", "DDB_G0290631", "Q8T8P3", "DDB_G0293194", "Q54N40", "DDB_G0285523", "Q55FL0", "DDB_G0268564", "Q54VX0", "DDB_G0280367", "Q86AC7", "DDB_G0276913", "Q54H86", "DDB_G0289623", "Q54DG1", "DDB_G0292270", "Q54C55", "DDB_G0293264", "Q54CL3", "DDB_G0292870", "Q76P23", "DDB_G0272346", "Q1ZXK7", "DDB_G0276169", "Q550G0", "DDB_G0277113", "DDB_G0281213", "Q54U86", "DDB_G0281213", "Q555I0", "DDB_G0274873", "Q54ZX5", "DDB_G0290631", "Q54FR4", "DDB_G0290631", "Q54GD8", "DDB_G0290631", "Q54XX9", "DDB_G0290631", "Q8T8P3", "DDB_G0293194", "Q54N40", "DDB_G0285523", "Q55FL0", "DDB_G0268564", "Q54VX0", "DDB_G0280367", "Q86AC7", "DDB_G0276913", "Q54H86", "DDB_G0289623", "Q54DG1", "DDB_G0292270", "Q54C55", "DDB_G0293264", "Q54CL3", "DDB_G0292870", "Q76P23", "DDB_G0272346", "Q1ZXK7", "DDB_G0276169", "Q550G0", "DDB_G0277113" ] }, "reaction_10604817": { "compartment": "compartment_70101", "id": "reaction_10604817", "reactome": "R-DDI-5226999", "name": "ADD1:ADD3 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604813", "species_10604805" ], "products": [ "species_10604815" ], "modifiers": [], "additional_components": [ "Q54T47", "DDB_G0282009", "DDB_G0279449", "Q54WT5", "DDB_G0279449", "Q54T47", "DDB_G0282009" ] }, "reaction_10605174": { "compartment": "compartment_70101", "id": "reaction_10605174", "reactome": "R-DDI-5339528", "name": "TUSC3 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10605171", "catalyst" ] ], "additional_components": [ "DDB_G0285537" ] }, "reaction_10604809": { "compartment": "compartment_70101", "id": "reaction_10604809", "reactome": "R-DDI-5226979", "name": "ADD1:ADD2 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604805", "species_10604800" ], "products": [ "species_10604807" ], "modifiers": [], "additional_components": [ "DDB_G0279449", "Q54T47", "DDB_G0282009", "Q54T47", "DDB_G0282009", "Q54WT5", "DDB_G0279449" ] }, "reaction_10605163": { "compartment": "compartment_70101", "id": "reaction_10605163", "reactome": "R-DDI-5336466", "name": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29926" ], "products": [ "species_109496" ], "modifiers": [ [ "species_10605160", "catalyst" ] ], "additional_components": [ "DDB_G0275813" ] }, "reaction_10605179": { "compartment": "compartment_70101", "id": "reaction_10605179", "reactome": "R-DDI-5339538", "name": "MAGT1 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10605176", "catalyst" ] ], "additional_components": [ "DDB_G0285537" ] }, "reaction_10582416": { "compartment": "compartment_7660", "id": "reaction_10582416", "reactome": "R-DDI-77090", "name": "Methylation of GMP-cap by RNA Methyltransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10582409" ], "products": [ "species_10582382", "species_77502", "species_10582413", "species_10580699", "species_10578881" ], "modifiers": [ [ "species_10582409", "catalyst" ] ], "additional_components": [ "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661", "DDB_G0287661", "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661" ] }, "reaction_10582402": { "compartment": "compartment_7660", "id": "reaction_10582402", "reactome": "R-DDI-77081", "name": "Formation of the CE:GMP intermediate complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582392", "species_113571" ], "products": [ "species_10582399", "species_111349" ], "modifiers": [ [ "species_10582392", "catalyst" ] ], "additional_components": [ "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661", "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661", "species_113578", "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661" ] }, "reaction_10582418": { "compartment": "compartment_7660", "id": "reaction_10582418", "reactome": "R-DDI-77094", "name": "Formation of cap binding complex (CBC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10578795", "species_10578800" ], "products": [ "species_10578802" ], "modifiers": [], "additional_components": [ "DDB_G0287197", "DDB_G0269814", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197" ] }, "reaction_10582420": { "compartment": "compartment_7660", "id": "reaction_10582420", "reactome": "R-DDI-77095", "name": "Recognition and binding of the mRNA cap by the cap-binding complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10578802", "species_10578881" ], "products": [ "species_10578883" ], "modifiers": [], "additional_components": [ "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197" ] }, "reaction_10582407": { "compartment": "compartment_7660", "id": "reaction_10582407", "reactome": "R-DDI-77083", "name": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582399" ], "products": [ "species_10582404" ], "modifiers": [ [ "species_10582399", "catalyst" ] ], "additional_components": [ "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661", "species_113578", "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661", "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661", "species_113578" ] }, "reaction_10582390": { "compartment": "compartment_7660", "id": "reaction_10582390", "reactome": "R-DDI-77077", "name": "Capping complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_72084", "species_29428", "species_10582384" ], "products": [ "species_10582388" ], "modifiers": [], "additional_components": [ "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661", "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661" ] }, "reaction_10582395": { "compartment": "compartment_7660", "id": "reaction_10582395", "reactome": "R-DDI-77078", "name": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582388" ], "products": [ "species_113550", "species_10582392" ], "modifiers": [ [ "species_10582388", "catalyst" ] ], "additional_components": [ "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661", "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661", "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661" ] }, "reaction_10582411": { "compartment": "compartment_7660", "id": "reaction_10582411", "reactome": "R-DDI-77085", "name": "Dissociation of transcript with 5'-GMP from GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582404" ], "products": [ "species_10582409" ], "modifiers": [], "additional_components": [ "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661", "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661" ] }, "reaction_10624148": { "compartment": "compartment_7660", "id": "reaction_10624148", "reactome": "R-DDI-8979071", "name": "KDM6B binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602196", "species_111793" ], "products": [ "species_10602198" ], "modifiers": [], "additional_components": [ "DDB_G0269194", "species_71067", "O77033", "DDB_G0269194" ] }, "reaction_10602201": { "compartment": "compartment_7660", "id": "reaction_10602201", "reactome": "R-DDI-3222593", "name": "KDM6B demethylates H3K27me3 on p16INK4A promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602189", "species_113671" ], "products": [ "species_10602191", "species_159939" ], "modifiers": [ [ "species_10602198", "catalyst" ] ], "additional_components": [ "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863", "O15819", "DDB_G0267402", "Q54F38", "DDB_G0291185", "Q76NW2", "DDB_G0276863", "species_71067", "O77033", "DDB_G0269194" ] }, "reaction_10594065": { "compartment": "compartment_70101", "id": "reaction_10594065", "reactome": "R-DDI-708349", "name": "Activated NOD2 oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584517" ], "products": [ "species_10584519" ], "modifiers": [], "additional_components": [ "Q86KC0", "DDB_G0274183", "species_708341", "Q86KC0", "DDB_G0274183", "species_708341" ] }, "reaction_10594037": { "compartment": "compartment_70101", "id": "reaction_10594037", "reactome": "R-DDI-622310", "name": "Activated NOD1 oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584509" ], "products": [ "species_10584513" ], "modifiers": [], "additional_components": [ "species_622271", "Q86KC0", "DDB_G0274183", "species_622271", "Q86KC0", "DDB_G0274183" ] }, "reaction_10627336": { "compartment": "compartment_70101", "id": "reaction_10627336", "reactome": "R-DDI-9676160", "name": "AAMP binds NOD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627244", "species_10584515" ], "products": [ "species_10627334" ], "modifiers": [], "additional_components": [ "DDB_G0269344", "DDB_G0274183", "Q86KC0", "DDB_G0274183", "Q55E90", "DDB_G0269344" ] }, "reaction_10584557": { "compartment": "compartment_70101", "id": "reaction_10584557", "reactome": "R-DDI-168405", "name": "Activated NOD oligomer recruites RIP2 (RICK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584553", "species_10584521" ], "products": [ "species_10584555" ], "modifiers": [], "additional_components": [ "Q54IP4", "DDB_G0288617", "Q54Y55", "DDB_G0278409", "Q86HG9", "DDB_G0271682", "Q54RB7", "DDB_G0283267", "Q54U31", "DDB_G0281343", "Q54G43", "DDB_G0290451", "species_622271", "Q86KC0", "DDB_G0274183", "species_708341", "Q54IP4", "DDB_G0288617", "Q54Y55", "DDB_G0278409", "Q86HG9", "DDB_G0271682", "Q54RB7", "DDB_G0283267", "Q54U31", "DDB_G0281343", "Q54G43", "DDB_G0290451", "species_622271", "Q86KC0", "DDB_G0274183", "species_708341" ] }, "reaction_10584511": { "compartment": "compartment_70101", "id": "reaction_10584511", "reactome": "R-DDI-168400", "name": "iE-DAP elicits a NOD1 response", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584507", "species_622271" ], "products": [ "species_10584509" ], "modifiers": [], "additional_components": [ "DDB_G0274183", "species_622271", "Q86KC0", "DDB_G0274183" ] }, "reaction_10584559": { "compartment": "compartment_70101", "id": "reaction_10584559", "reactome": "R-DDI-168412", "name": "MDP elicits a NOD2 response", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_708341", "species_10584515" ], "products": [ "species_10584517" ], "modifiers": [], "additional_components": [ "DDB_G0274183", "Q86KC0", "DDB_G0274183", "species_708341" ] }, "reaction_10615701": { "compartment": "compartment_1470028", "id": "reaction_10615701", "reactome": "R-DDI-6798751", "name": "Exocytosis of azurophil granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615569" ], "products": [ "species_10615699" ], "modifiers": [], "additional_components": [ "P13723", "DDB_G0287033", "Q559Q3", "DDB_G0272298", "Q54SZ9", "DDB_G0287185", "Q55BL4", "DDB_G0287185", "Q54SW1", "DDB_G0287185", "Q54SW2", "DDB_G0287185", "Q54TL9", "DDB_G0287185", "Q54KP7", "DDB_G0287185", "Q54YD2", "DDB_G0287185", "Q54MV4", "DDB_G0287185", "Q54SZ8", "DDB_G0287185", "Q54VE2", "DDB_G0280423", "Q54P50", "DDB_G0287731", "B0G108", "DDB_G0287731", "Q554H6", "DDB_G0287731", "Q54JY8", "DDB_G0287731", "Q86HR5", "DDB_G0274461", "P34036", "DDB_G0276355", "P34114", "DDB_G0291123", "Q00766", "DDB_G0281383", "Q54QQ0", "DDB_G0283701", "Q8MML4", "DDB_G0274551", "Q54F36", "DDB_G0291137", "Q54XV8", "DDB_G0278563", "Q54HT4", "DDB_G0289231", "Q54H23", "DDB_G0289749", "Q54SE2", "DDB_G0282517", "Q55F06", "DDB_G0279583", "Q54WK5", "DDB_G0279583", "Q54JM5", "DDB_G0287953", "Q54I39", "DDB_G0289029", "Q55FM7", "DDB_G0268034", "O96621", "DDB_G0272106", "C7FZY2", "DDB_G0295845", "Q553U5", "DDB_G0275179", "Q54ES9", "DDB_G0291358", "P54654", "DDB_G0288769", "Q552J0", "DDB_G0276233", "C7G009", "DDB_G0295811", "Q557G3", "DDB_G0273467", "Q54WW0", "DDB_G0290421", "Q54G40", "DDB_G0290421", "Q54EG4", "DDB_G0291524", "Q55B10", "DDB_G0271490", "P32256", "DDB_G0269196", "P34098", "DDB_G0292206", "Q6TMK4", "DDB_G0277275", "Q54LD6", "DDB_G0286691", "P10901", "DDB_G0274391", "Q551C1", "DDB_G0276661", "P90532", "DDB_G0288065", "Q55G10", "DDB_G0268472", "Q54HL4", "DDB_G0289365", "Q54JY2", "DDB_G0287739", "Q1ZXG4", "DDB_G0282361", "P24639", "DDB_G0269160", "Q54PW0", "DDB_G0284261", "Q54HV8", "DDB_G0289195", "Q54YA2", "DDB_G0278341", "Q55BA2", "DDB_G0271242", "Q54GE1", "DDB_G0290217", "P34114", "DDB_G0291123", "Q00766", "DDB_G0281383", "Q54I39", "DDB_G0289029", "P10901", "DDB_G0274391", "Q551C1", "DDB_G0276661", "P90532", "DDB_G0288065", "Q54G40", "DDB_G0290421", "Q54WW0", "DDB_G0290421", "Q552J0", "DDB_G0276233", "P34098", "DDB_G0292206", "Q55FM7", "DDB_G0268034", "Q553U5", "DDB_G0275179", "Q55BA2", "DDB_G0271242", "Q6TMK4", "DDB_G0277275", "Q54QQ0", "DDB_G0283701", "P24639", "DDB_G0269160", "Q54PW0", "DDB_G0284261", "Q55G10", "DDB_G0268472", "Q54YA2", "DDB_G0278341", "Q1ZXG4", "DDB_G0282361", "Q54GE1", "DDB_G0290217", "P13723", "DDB_G0287033", "Q559Q3", "DDB_G0272298", "Q86HR5", "DDB_G0274461", "B0G108", "DDB_G0287731", "Q54JY8", "DDB_G0287731", "Q54P50", "DDB_G0287731", "Q554H6", "DDB_G0287731", "P34036", "DDB_G0276355", "Q54F36", "DDB_G0291137", "Q54XV8", "DDB_G0278563", "Q8MML4", "DDB_G0274551", "Q55F06", "DDB_G0279583", "Q54WK5", "DDB_G0279583", "Q54H23", "DDB_G0289749", "Q54HT4", "DDB_G0289231", "C7FZY2", "DDB_G0295845", "Q54ES9", "DDB_G0291358", "C7G009", "DDB_G0295811", "Q557G3", "DDB_G0273467", "P32256", "DDB_G0269196", "Q54HL4", "DDB_G0289365", "Q54JY2", "DDB_G0287739", "Q54SE2", "DDB_G0282517", "Q54JM5", "DDB_G0287953", "O96621", "DDB_G0272106", "P54654", "DDB_G0288769", "Q54SZ9", "DDB_G0287185", "Q54TL9", "DDB_G0287185", "Q54YD2", "DDB_G0287185", "Q54KP7", "DDB_G0287185", "Q55BL4", "DDB_G0287185", "Q54MV4", "DDB_G0287185", "Q54SW1", "DDB_G0287185", "Q54SW2", "DDB_G0287185", "Q54SZ8", "DDB_G0287185", "Q54LD6", "DDB_G0286691", "Q54VE2", "DDB_G0280423", "Q54HV8", "DDB_G0289195", "Q54EG4", "DDB_G0291524", "Q55B10", "DDB_G0271490" ] }, "reaction_10616165": { "compartment": "compartment_6800424", "id": "reaction_10616165", "reactome": "R-DDI-6800426", "name": "Exocytosis of ficolin-rich granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616149" ], "products": [ "species_10616163" ], "modifiers": [], "additional_components": [ "Q1ZXA8", "DDB_G0292160", "Q54QG5", "DDB_G0283893", "P54642", "DDB_G0274381", "Q54MJ8", "DDB_G0285897", "Q54H23", "DDB_G0289749", "Q557H3", "DDB_G0273473", "Q54R04", "DDB_G0283525", "Q86JN1", "DDB_G0272062", "Q55D50", "DDB_G0269790", "Q869Q3", "DDB_G0274519", "Q86KI1", "DDB_G0273439", "Q54E04", "DDB_G0291858", "Q869V1", "DDB_G0276973", "P34144", "DDB_G0277869", "Q86A88", "DDB_G0274815", "Q54Z16", "DDB_G0289735", "Q54H32", "DDB_G0289735", "Q54U63", "DDB_G0280971", "Q55AV3", "DDB_G0271502", "Q55DM1", "DDB_G0269150", "Q86JF2", "DDB_G0271504", "Q54RQ8", "DDB_G0282925", "Q54CM5", "DDB_G0292814", "Q23924", "DDB_G0284735", "Q54YP0", "DDB_G0278613", "Q559U0", "DDB_G0278613", "Q54U95", "DDB_G0281325", "Q54CI8", "DDB_G0292904", "Q54RQ8", "DDB_G0282925", "Q54U63", "DDB_G0280971", "Q55AV3", "DDB_G0271502", "Q55DM1", "DDB_G0269150", "Q86JF2", "DDB_G0271504", "Q86JN1", "DDB_G0272062", "Q54QG5", "DDB_G0283893", "Q23924", "DDB_G0284735", "Q54E04", "DDB_G0291858", "Q54YP0", "DDB_G0278613", "Q559U0", "DDB_G0278613", "Q54CI8", "DDB_G0292904", "Q86KI1", "DDB_G0273439", "Q55D50", "DDB_G0269790", "Q869Q3", "DDB_G0274519", "Q54CM5", "DDB_G0292814", "P34144", "DDB_G0277869", "Q86A88", "DDB_G0274815", "Q54H23", "DDB_G0289749", "Q869V1", "DDB_G0276973", "Q54U95", "DDB_G0281325", "P54642", "DDB_G0274381", "Q54H32", "DDB_G0289735", "Q54Z16", "DDB_G0289735", "Q54R04", "DDB_G0283525", "Q54MJ8", "DDB_G0285897", "Q557H3", "DDB_G0273473", "Q1ZXA8", "DDB_G0292160" ] }, "reaction_10614836": { "compartment": "compartment_6799713", "id": "reaction_10614836", "reactome": "R-DDI-6798747", "name": "Exocytosis of tertiary granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614736" ], "products": [ "species_10614834" ], "modifiers": [], "additional_components": [ "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q55GA1", "DDB_G0293626", "Q54BH1", "DDB_G0293626", "P54642", "DDB_G0274381", "Q55D50", "DDB_G0269790", "Q55CV4", "DDB_G0270682", "Q55CV5", "DDB_G0269110", "Q55CV7", "DDB_G0270986", "Q55CW7", "DDB_G0269872", "Q54YP0", "DDB_G0278613", "Q559U0", "DDB_G0278613", "Q54QG5", "DDB_G0283893", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q86JN1", "DDB_G0272062", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "Q54LX9", "DDB_G0286315", "Q869V1", "DDB_G0276973", "Q54F59", "DDB_G0291091", "Q86J23", "DDB_G0274833", "Q54F95", "DDB_G0290995", "Q54K65", "DDB_G0290995", "Q86GL4", "DDB_G0287101", "Q9XYS3", "DDB_G0289653", "Q54F44", "DDB_G0291117", "Q867X6", "DDB_G0267460", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q86A88", "DDB_G0274815", "Q54Q49", "DDB_G0284155", "Q54UK0", "DDB_G0281031", "Q54WR4", "DDB_G0279483", "Q54Z25", "DDB_G0277949", "Q23924", "DDB_G0284735", "Q54U95", "DDB_G0281325", "Q54U08", "DDB_G0281401", "Q54RQ8", "DDB_G0282925", "Q54U63", "DDB_G0280971", "Q86JF2", "DDB_G0271504", "Q55AV3", "DDB_G0271502", "Q55DM1", "DDB_G0269150", "Q54CM5", "DDB_G0292814", "P36410", "DDB_G0281337", "Q54L55", "DDB_G0286891", "Q551T0", "DDB_G0286891", "Q553A4", "DDB_G0286891", "Q55E61", "DDB_G0286891", "Q86H52", "DDB_G0286891", "Q867X6", "DDB_G0267460", "Q86JN1", "DDB_G0272062", "Q54QG5", "DDB_G0283893", "Q23924", "DDB_G0284735", "Q54BH1", "DDB_G0293626", "Q55GA1", "DDB_G0293626", "Q54F95", "DDB_G0290995", "Q54K65", "DDB_G0290995", "Q55CV4", "DDB_G0270682", "Q55CV5", "DDB_G0269110", "Q55CV7", "DDB_G0270986", "Q55CW7", "DDB_G0269872", "Q86A88", "DDB_G0274815", "Q869V1", "DDB_G0276973", "Q54U08", "DDB_G0281401", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54RQ8", "DDB_G0282925", "Q54U63", "DDB_G0280971", "Q55AV3", "DDB_G0271502", "Q55DM1", "DDB_G0269150", "Q86JF2", "DDB_G0271504", "P36410", "DDB_G0281337", "Q54YP0", "DDB_G0278613", "Q559U0", "DDB_G0278613", "Q55D50", "DDB_G0269790", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "Q54CM5", "DDB_G0292814", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54U95", "DDB_G0281325", "Q54F59", "DDB_G0291091", "Q54WR4", "DDB_G0279483", "Q54Z25", "DDB_G0277949", "Q54Q49", "DDB_G0284155", "Q54UK0", "DDB_G0281031", "P54642", "DDB_G0274381", "Q55E61", "DDB_G0286891", "Q86H52", "DDB_G0286891", "Q54L55", "DDB_G0286891", "Q551T0", "DDB_G0286891", "Q553A4", "DDB_G0286891", "Q86J23", "DDB_G0274833", "Q54LX9", "DDB_G0286315", "Q54F44", "DDB_G0291117", "Q86GL4", "DDB_G0287101", "Q9XYS3", "DDB_G0289653" ] }, "reaction_10616436": { "compartment": "compartment_984", "id": "reaction_10616436", "reactome": "R-DDI-6800434", "name": "Exocytosis of ficolin-rich granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616414" ], "products": [ "species_10616434" ], "modifiers": [], "additional_components": [ "Q54UJ0", "DDB_G0281051", "P04989", "DDB_G0279799", "Q23894", "DDB_G0283867", "Q54RQ2", "DDB_G0282991", "Q54TR1", "DDB_G0281605", "Q54UH2", "DDB_G0282991", "Q54UH3", "DDB_G0282991", "Q86KD4", "DDB_G0282991", "Q54UB5", "DDB_G0281315", "Q86JA1", "DDB_G0276917", "Q54PN7", "DDB_G0284415", "Q556L1", "DDB_G0272590", "P90532", "DDB_G0288065", "P15112", "DDB_G0288373", "Q55GA9", "DDB_G0267742", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "O96626", "DDB_G0288319", "Q54I79", "DDB_G0288937", "Q54JY2", "DDB_G0287739", "C7G034", "DDB_G0285063", "O96621", "DDB_G0272106", "Q54PG1", "DDB_G0284589", "Q54YA2", "DDB_G0278341", "B0G198", "DDB_G0295683", "Q54GE1", "DDB_G0290217", "Q55E06", "DDB_G0269444", "Q54QQ0", "DDB_G0283701", "Q54RF5", "DDB_G0283247", "Q552J0", "DDB_G0276233", "Q54I82", "DDB_G0288933", "Q75JR2", "DDB_G0272210", "Q5R1U3", "DDB_G0277001", "Q556T3", "DDB_G0273107", "Q54QS2", "DDB_G0283663", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54B14", "DDB_G0293986", "Q55FR5", "DDB_G0267990", "Q54K94", "DDB_G0287569", "Q556U5", "DDB_G0273095", "Q54QV7", "DDB_G0283575", "Q54VI4", "DDB_G0280317", "Q556G3", "DDB_G0272632", "Q556P3", "DDB_G0273153", "Q55FF3", "DDB_G0268138", "Q86AU1", "DDB_G0274263", "Q54PF1", "DDB_G0284601", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "C7G028", "DDB_G0284307", "Q8MUF9", "DDB_G0269200", "Q5V9E9", "DDB_G0283673", "Q54UQ2", "DDB_G0280897", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "Q23919", "DDB_G0288483", "Q54S93", "DDB_G0282595", "O96923", "DDB_G0291125", "P10733", "DDB_G0289327", "Q551I6", "DDB_G0276571", "Q86CR9", "DDB_G0271096", "Q54QS3", "DDB_G0283661", "Q54MA9", "DDB_G0286069", "Q54W35", "DDB_G0279909", "Q86A67", "DDB_G0274375", "Q54DD0", "DDB_G0292266", "Q54NQ0", "DDB_G0285105", "Q86IJ1", "DDB_G0272566", "Q54BC6", "DDB_G0293752", "Q54QK4", "DDB_G0283795", "Q1ZXD3", "DDB_G0288621", "Q86KD1", "DDB_G0274167", "Q55C75", "DDB_G0270188", "Q54WI8", "DDB_G0279633", "O77229", "DDB_G0274595", "Q00766", "DDB_G0281383", "Q54IS1", "DDB_G0288563", "Q54L24", "DDB_G0286945", "O76856", "DDB_G0279411", "P36415", "DDB_G0269144", "P54651", "DDB_G0267400", "Q55C24", "DDB_G0270260", "P52922", "DDB_G0269148", "Q54QR2", "DDB_G0283679", "P34118", "DDB_G0269156", "Q54DM7", "DDB_G0292122", "Q55G04", "DDB_G0268538", "Q86A21", "DDB_G0272969", "P34093", "DDB_G0279911", "Q555L5", "DDB_G0274859", "Q54NE6", "DDB_G0285311", "Q54J84", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54VR1", "DDB_G0288221", "C7G034", "DDB_G0285063", "Q8MUF9", "DDB_G0269200", "Q54PG1", "DDB_G0284589", "Q55GA9", "DDB_G0267742", "Q55E06", "DDB_G0269444", "Q556U5", "DDB_G0273095", "P34093", "DDB_G0279911", "Q86JA1", "DDB_G0276917", "Q86A21", "DDB_G0272969", "Q54UB5", "DDB_G0281315", "Q55G04", "DDB_G0268538", "Q54UJ0", "DDB_G0281051", "Q54DM7", "DDB_G0292122", "Q54NQ0", "DDB_G0285105", "P34118", "DDB_G0269156", "Q86IJ1", "DDB_G0272566", "O96621", "DDB_G0272106", "Q54QR2", "DDB_G0283679", "Q54BC6", "DDB_G0293752", "Q1ZXD3", "DDB_G0288621", "P54651", "DDB_G0267400", "Q55C75", "DDB_G0270188", "Q54JY2", "DDB_G0287739", "P36415", "DDB_G0269144", "Q54WI8", "DDB_G0279633", "Q54L24", "DDB_G0286945", "Q54K94", "DDB_G0287569", "Q00766", "DDB_G0281383", "Q23919", "DDB_G0288483", "P52922", "DDB_G0269148", "Q556G3", "DDB_G0272632", "Q556P3", "DDB_G0273153", "Q55FF3", "DDB_G0268138", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q54VI4", "DDB_G0280317", "Q86CR9", "DDB_G0271096", "Q54QS3", "DDB_G0283661", "Q54MA9", "DDB_G0286069", "Q54W35", "DDB_G0279909", "Q55C24", "DDB_G0270260", "Q54GE1", "DDB_G0290217", "Q54DD0", "DDB_G0292266", "Q54YA2", "DDB_G0278341", "O96626", "DDB_G0288319", "Q86A67", "DDB_G0274375", "Q54I79", "DDB_G0288937", "Q54QQ0", "DDB_G0283701", "Q552J0", "DDB_G0276233", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54VR1", "DDB_G0288221", "Q54J84", "DDB_G0288221", "P90532", "DDB_G0288065", "Q54NE6", "DDB_G0285311", "Q556L1", "DDB_G0272590", "Q555L5", "DDB_G0274859", "Q54PN7", "DDB_G0284415", "Q54UH2", "DDB_G0282991", "Q54UH3", "DDB_G0282991", "Q86KD4", "DDB_G0282991", "P04989", "DDB_G0279799", "Q23894", "DDB_G0283867", "Q54RQ2", "DDB_G0282991", "Q54TR1", "DDB_G0281605", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "P15112", "DDB_G0288373", "Q54IS1", "DDB_G0288563", "Q54QK4", "DDB_G0283795", "P10733", "DDB_G0289327", "Q551I6", "DDB_G0276571", "O96923", "DDB_G0291125", "Q54S93", "DDB_G0282595", "B0G198", "DDB_G0295683", "Q54UQ2", "DDB_G0280897", "Q5V9E9", "DDB_G0283673", "Q54NT2", "DDB_G0284997", "Q54IA6", "DDB_G0288895", "Q75JR2", "DDB_G0272210", "C7G028", "DDB_G0284307", "Q54B14", "DDB_G0293986", "Q54PF1", "DDB_G0284601", "Q55FR5", "DDB_G0267990", "O77229", "DDB_G0274595", "Q86KD1", "DDB_G0274167", "Q54I82", "DDB_G0288933", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q5R1U3", "DDB_G0277001", "O76856", "DDB_G0279411", "Q556T3", "DDB_G0273107", "Q54RF5", "DDB_G0283247" ] }, "reaction_10615963": { "compartment": "compartment_6799351", "id": "reaction_10615963", "reactome": "R-DDI-6799350", "name": "Exocytosis of specific granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615937" ], "products": [ "species_10615961" ], "modifiers": [], "additional_components": [ "Q54I48", "DDB_G0289013", "Q54IJ2", "DDB_G0288717", "Q867X6", "DDB_G0267460", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q86A77", "DDB_G0274331", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "Q54U08", "DDB_G0281401", "Q02465", "DDB_G0289075", "Q54F44", "DDB_G0291117", "Q86GL4", "DDB_G0287101", "Q9XYS3", "DDB_G0289653", "Q54CM5", "DDB_G0292814", "Q54LX9", "DDB_G0286315", "Q54F59", "DDB_G0291091", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "P34138", "DDB_G0277865", "P54637", "DDB_G0282145", "Q86J23", "DDB_G0274833", "Q55BH9", "DDB_G0271342", "Q54EU4", "DDB_G0291332", "Q54HS9", "DDB_G0289247", "Q54DG1", "DDB_G0292270", "Q54F95", "DDB_G0290995", "Q54K65", "DDB_G0290995", "Q55FQ9", "DDB_G0267440", "Q9BKJ9", "DDB_G0287035", "Q9XYS8", "DDB_G0267406", "Q54BH1", "DDB_G0293626", "Q55GA1", "DDB_G0293626", "Q54Z55", "DDB_G0277773", "Q869T7", "DDB_G0274409", "Q54S39", "DDB_G0282683", "O76173", "DDB_G0269174", "Q54L55", "DDB_G0286891", "Q551T0", "DDB_G0286891", "Q553A4", "DDB_G0286891", "Q55E61", "DDB_G0286891", "Q86H52", "DDB_G0286891", "Q54S63", "DDB_G0282651", "Q55EF0", "DDB_G0269262", "Q55EG6", "DDB_G0268910", "Q86JC8", "DDB_G0275955", "Q86JP5", "DDB_G0271980", "Q8T193", "DDB_G0294577", "Q1ZXG2", "DDB_G0294577", "Q1ZXN9", "DDB_G0294577", "Q54E92", "DDB_G0291738", "Q54FL2", "DDB_G0290783", "Q54G48", "DDB_G0290407", "Q54P07", "DDB_G0285051", "Q54S62", "DDB_G0294577", "Q551J1", "DDB_G0276567", "Q55D94", "DDB_G0269738", "Q559U0", "DDB_G0278613", "Q54YP0", "DDB_G0278613", "Q1ZXA8", "DDB_G0292160", "Q54QG5", "DDB_G0283893", "Q54Q49", "DDB_G0284155", "Q54UK0", "DDB_G0281031", "Q54WR4", "DDB_G0279483", "Q54Z25", "DDB_G0277949", "Q55CV4", "DDB_G0270682", "Q55CV5", "DDB_G0269110", "Q55CV7", "DDB_G0270986", "Q55CW7", "DDB_G0269872", "Q867X6", "DDB_G0267460", "O76173", "DDB_G0269174", "Q54QG5", "DDB_G0283893", "Q54BH1", "DDB_G0293626", "Q55GA1", "DDB_G0293626", "Q54F95", "DDB_G0290995", "Q54K65", "DDB_G0290995", "Q54DG1", "DDB_G0292270", "Q55CV4", "DDB_G0270682", "Q55CV5", "DDB_G0269110", "Q55CV7", "DDB_G0270986", "Q55CW7", "DDB_G0269872", "Q54U08", "DDB_G0281401", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54I48", "DDB_G0289013", "Q54IJ2", "DDB_G0288717", "Q54EU4", "DDB_G0291332", "Q54HS9", "DDB_G0289247", "Q55D94", "DDB_G0269738", "Q55BH9", "DDB_G0271342", "Q54YP0", "DDB_G0278613", "Q559U0", "DDB_G0278613", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "Q54CM5", "DDB_G0292814", "Q54S63", "DDB_G0282651", "Q55EF0", "DDB_G0269262", "Q55EG6", "DDB_G0268910", "Q86JC8", "DDB_G0275955", "Q86JP5", "DDB_G0271980", "Q8T193", "DDB_G0294577", "Q1ZXG2", "DDB_G0294577", "Q1ZXN9", "DDB_G0294577", "Q54E92", "DDB_G0291738", "Q54FL2", "DDB_G0290783", "Q54G48", "DDB_G0290407", "Q54P07", "DDB_G0285051", "Q54S62", "DDB_G0294577", "P34138", "DDB_G0277865", "P54637", "DDB_G0282145", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54S39", "DDB_G0282683", "Q869T7", "DDB_G0274409", "Q86A77", "DDB_G0274331", "Q9XYS8", "DDB_G0267406", "Q55FQ9", "DDB_G0267440", "Q9BKJ9", "DDB_G0287035", "Q55E61", "DDB_G0286891", "Q86H52", "DDB_G0286891", "Q54L55", "DDB_G0286891", "Q551T0", "DDB_G0286891", "Q553A4", "DDB_G0286891", "Q54WR4", "DDB_G0279483", "Q54Z25", "DDB_G0277949", "Q54Q49", "DDB_G0284155", "Q54UK0", "DDB_G0281031", "Q54F59", "DDB_G0291091", "Q02465", "DDB_G0289075", "Q551J1", "DDB_G0276567", "Q54LX9", "DDB_G0286315", "Q86J23", "DDB_G0274833", "Q54Z55", "DDB_G0277773", "Q54F44", "DDB_G0291117", "Q86GL4", "DDB_G0287101", "Q9XYS3", "DDB_G0289653", "Q1ZXA8", "DDB_G0292160" ] }, "reaction_10614058": { "compartment": "compartment_6798757", "id": "reaction_10614058", "reactome": "R-DDI-6798739", "name": "Exocytosis of azurophil granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613932" ], "products": [ "species_10614056" ], "modifiers": [], "additional_components": [ "Q54F95", "DDB_G0290995", "Q54K65", "DDB_G0290995", "Q54U08", "DDB_G0281401", "Q54X10", "DDB_G0279277", "Q54R04", "DDB_G0283525", "Q54DE8", "DDB_G0292310", "Q54ET2", "DDB_G0291352", "P18613", "DDB_G0291237", "Q552S3", "DDB_G0275917", "Q54FL2", "DDB_G0290783", "Q54G48", "DDB_G0290407", "Q54P07", "DDB_G0285051", "Q54S62", "DDB_G0294577", "Q54S63", "DDB_G0282651", "Q55EF0", "DDB_G0269262", "Q55EG6", "DDB_G0268910", "Q86JC8", "DDB_G0275955", "Q86JP5", "DDB_G0271980", "Q8T193", "DDB_G0294577", "Q1ZXG2", "DDB_G0294577", "Q1ZXN9", "DDB_G0294577", "Q54E92", "DDB_G0291738", "Q86JP3", "DDB_G0271984", "Q54FY7", "DDB_G0290529", "Q54P51", "DDB_G0284791", "Q55GG1", "DDB_G0267688", "Q7YXU4", "DDB_G0293008", "Q86K21", "DDB_G0272875", "Q1ZXB3", "DDB_G0291498", "Q54H23", "DDB_G0289749", "Q556J9", "DDB_G0272889", "Q54WE0", "DDB_G0279713", "Q55GN5", "DDB_G0267590", "P54642", "DDB_G0274381", "Q54XS7", "DDB_G0278773", "Q54LZ3", "DDB_G0286293", "Q54E62", "DDB_G0291780", "Q551J1", "DDB_G0276567", "O76173", "DDB_G0269174", "Q1ZXA8", "DDB_G0292160", "Q54P71", "DDB_G0284755", "Q54P72", "DDB_G0284755", "Q54PR9", "DDB_G0284363", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q8T6J2", "DDB_G0274119", "Q8T6J5", "DDB_G0267438", "Q54BT5", "DDB_G0293436", "Q555Z5", "DDB_G0274121", "Q55BC0", "DDB_G0271138", "Q8T5Z7", "DDB_G0291994", "Q8T6J1", "DDB_G0291245", "Q55D50", "DDB_G0269790", "Q54N33", "DDB_G0285537", "P20790", "DDB_G0280043", "P20791", "DDB_G0276399", "Q1ZXE7", "DDB_G0286169", "Q54RY4", "DDB_G0282899", "Q54JT7", "DDB_G0287801", "Q54WG1", "DDB_G0279675", "O76173", "DDB_G0269174", "Q54DE8", "DDB_G0292310", "Q54ET2", "DDB_G0291352", "Q54WG1", "DDB_G0279675", "Q54F95", "DDB_G0290995", "Q54K65", "DDB_G0290995", "Q54X10", "DDB_G0279277", "Q54U08", "DDB_G0281401", "Q552S3", "DDB_G0275917", "P20790", "DDB_G0280043", "P20791", "DDB_G0276399", "Q1ZXE7", "DDB_G0286169", "Q54RY4", "DDB_G0282899", "Q54E62", "DDB_G0291780", "Q54LZ3", "DDB_G0286293", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54N33", "DDB_G0285537", "Q54P51", "DDB_G0284791", "Q55GG1", "DDB_G0267688", "Q1ZXB3", "DDB_G0291498", "Q54FY7", "DDB_G0290529", "Q7YXU4", "DDB_G0293008", "Q86K21", "DDB_G0272875", "Q8T6J2", "DDB_G0274119", "Q8T6J5", "DDB_G0267438", "Q54BT5", "DDB_G0293436", "Q555Z5", "DDB_G0274121", "Q55BC0", "DDB_G0271138", "Q8T5Z7", "DDB_G0291994", "Q8T6J1", "DDB_G0291245", "P18613", "DDB_G0291237", "Q54JT7", "DDB_G0287801", "Q54S63", "DDB_G0282651", "Q55EF0", "DDB_G0269262", "Q55EG6", "DDB_G0268910", "Q86JC8", "DDB_G0275955", "Q86JP5", "DDB_G0271980", "Q8T193", "DDB_G0294577", "Q1ZXG2", "DDB_G0294577", "Q1ZXN9", "DDB_G0294577", "Q54E92", "DDB_G0291738", "Q54FL2", "DDB_G0290783", "Q54G48", "DDB_G0290407", "Q54P07", "DDB_G0285051", "Q54S62", "DDB_G0294577", "Q54P71", "DDB_G0284755", "Q54P72", "DDB_G0284755", "Q54PR9", "DDB_G0284363", "Q86JP3", "DDB_G0271984", "Q54H23", "DDB_G0289749", "Q556J9", "DDB_G0272889", "Q54WE0", "DDB_G0279713", "Q55GN5", "DDB_G0267590", "P54642", "DDB_G0274381", "Q551J1", "DDB_G0276567", "Q54XS7", "DDB_G0278773", "Q54R04", "DDB_G0283525", "Q55D50", "DDB_G0269790", "Q1ZXA8", "DDB_G0292160" ] }, "reaction_10615338": { "compartment": "compartment_6799371", "id": "reaction_10615338", "reactome": "R-DDI-6798749", "name": "Exocytosis of specific granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615290" ], "products": [ "species_10615336" ], "modifiers": [], "additional_components": [ "Q54B14", "DDB_G0293986", "Q55BA2", "DDB_G0271242", "Q54HV8", "DDB_G0289195", "Q54F36", "DDB_G0291137", "Q54XV8", "DDB_G0278563", "Q8MML4", "DDB_G0274551", "O76856", "DDB_G0279411", "P05095", "DDB_G0268632", "Q54V78", "DDB_G0280565", "Q55D97", "DDB_G0270626", "Q54RX2", "DDB_G0282859", "Q54PB7", "DDB_G0292004", "Q54HL4", "DDB_G0289365", "Q54J84", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54VR1", "DDB_G0288221", "Q54JM9", "DDB_G0287939", "Q1ZXG2", "DDB_G0294577", "Q1ZXN9", "DDB_G0294577", "Q54E92", "DDB_G0291738", "Q54FL2", "DDB_G0290783", "Q54G48", "DDB_G0290407", "Q54P07", "DDB_G0285051", "Q54S62", "DDB_G0294577", "Q54S63", "DDB_G0282651", "Q55EF0", "DDB_G0269262", "Q55EG6", "DDB_G0268910", "Q86JC8", "DDB_G0275955", "Q86JP5", "DDB_G0271980", "Q8T193", "DDB_G0294577", "Q86IY4", "DDB_G0274339", "Q556T3", "DDB_G0273107", "Q55EK9", "DDB_G0268628", "Q6UK63", "DDB_G0287855", "Q6UK63", "DDB_G0287855", "Q54F36", "DDB_G0291137", "Q54XV8", "DDB_G0278563", "Q8MML4", "DDB_G0274551", "Q55EK9", "DDB_G0268628", "P05095", "DDB_G0268632", "Q54V78", "DDB_G0280565", "Q54B14", "DDB_G0293986", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54VR1", "DDB_G0288221", "Q54J84", "DDB_G0288221", "Q54JM9", "DDB_G0287939", "Q55BA2", "DDB_G0271242", "Q54RX2", "DDB_G0282859", "Q54HL4", "DDB_G0289365", "Q55D97", "DDB_G0270626", "O76856", "DDB_G0279411", "Q1ZXG2", "DDB_G0294577", "Q1ZXN9", "DDB_G0294577", "Q54E92", "DDB_G0291738", "Q54FL2", "DDB_G0290783", "Q54G48", "DDB_G0290407", "Q54P07", "DDB_G0285051", "Q54S62", "DDB_G0294577", "Q54S63", "DDB_G0282651", "Q55EF0", "DDB_G0269262", "Q55EG6", "DDB_G0268910", "Q86JC8", "DDB_G0275955", "Q86JP5", "DDB_G0271980", "Q8T193", "DDB_G0294577", "Q54PB7", "DDB_G0292004", "Q54HV8", "DDB_G0289195", "Q86IY4", "DDB_G0274339", "Q556T3", "DDB_G0273107" ] }, "reaction_10615210": { "compartment": "compartment_1462052", "id": "reaction_10615210", "reactome": "R-DDI-6798748", "name": "Exocytosis of secretory granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615050" ], "products": [ "species_10615208" ], "modifiers": [], "additional_components": [ "Q54NQ0", "DDB_G0285105", "Q86A67", "DDB_G0274375", "Q86IJ1", "DDB_G0272566", "P15112", "DDB_G0288373", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "Q555L5", "DDB_G0274859", "P34093", "DDB_G0279911", "Q86A21", "DDB_G0272969", "Q55G04", "DDB_G0268538", "Q54DM7", "DDB_G0292122", "P34118", "DDB_G0269156", "Q86CR9", "DDB_G0271096", "Q54QR2", "DDB_G0283679", "Q54QS3", "DDB_G0283661", "Q55C24", "DDB_G0270260", "P54651", "DDB_G0267400", "Q54LY5", "DDB_G0286303", "P36415", "DDB_G0269144", "Q54MA9", "DDB_G0286069", "Q54L24", "DDB_G0286945", "Q54W35", "DDB_G0279909", "Q00766", "DDB_G0281383", "Q54DD0", "DDB_G0292266", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q54VI4", "DDB_G0280317", "Q556G3", "DDB_G0272632", "Q556P3", "DDB_G0273153", "Q55FF3", "DDB_G0268138", "O96626", "DDB_G0288319", "Q54I79", "DDB_G0288937", "Q86KD1", "DDB_G0274167", "B0G198", "DDB_G0295683", "Q54UH3", "DDB_G0282991", "Q86KD4", "DDB_G0282991", "P04989", "DDB_G0279799", "Q23894", "DDB_G0283867", "Q54RQ2", "DDB_G0282991", "Q54TR1", "DDB_G0281605", "Q54UH2", "DDB_G0282991", "Q54E35", "DDB_G0291840", "O77229", "DDB_G0274595", "Q54PF1", "DDB_G0284601", "Q6TMK4", "DDB_G0277275", "C7G028", "DDB_G0284307", "Q54NE6", "DDB_G0285311", "Q54BC6", "DDB_G0293752", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "Q1ZXD3", "DDB_G0288621", "Q55C75", "DDB_G0270188", "Q54WI8", "DDB_G0279633", "C7G034", "DDB_G0285063", "Q54K94", "DDB_G0287569", "Q54PG1", "DDB_G0284589", "Q55E06", "DDB_G0269444", "Q54RF5", "DDB_G0283247", "Q54I82", "DDB_G0288933", "Q5R1U3", "DDB_G0277001", "Q54QS2", "DDB_G0283663", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54UJ0", "DDB_G0281051", "Q54UB5", "DDB_G0281315", "Q86JA1", "DDB_G0276917", "O96923", "DDB_G0291125", "P10733", "DDB_G0289327", "Q551I6", "DDB_G0276571", "Q54PN7", "DDB_G0284415", "Q556L1", "DDB_G0272590", "P90532", "DDB_G0288065", "Q75JR2", "DDB_G0272210", "Q54S93", "DDB_G0282595", "Q6UK63", "DDB_G0287855", "Q54UQ2", "DDB_G0280897", "Q556T3", "DDB_G0273107", "Q5V9E9", "DDB_G0283673", "Q55EK9", "DDB_G0268628", "Q552J0", "DDB_G0276233", "Q55FM7", "DDB_G0268034", "Q54QQ0", "DDB_G0283701", "Q54S93", "DDB_G0282595", "P10733", "DDB_G0289327", "Q551I6", "DDB_G0276571", "O96923", "DDB_G0291125", "P15112", "DDB_G0288373", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "Q54UH2", "DDB_G0282991", "Q54UH3", "DDB_G0282991", "Q86KD4", "DDB_G0282991", "P04989", "DDB_G0279799", "Q23894", "DDB_G0283867", "Q54RQ2", "DDB_G0282991", "Q54TR1", "DDB_G0281605", "C7G034", "DDB_G0285063", "Q54PG1", "DDB_G0284589", "Q55E06", "DDB_G0269444", "P34093", "DDB_G0279911", "Q86JA1", "DDB_G0276917", "Q86A21", "DDB_G0272969", "Q54UB5", "DDB_G0281315", "Q55G04", "DDB_G0268538", "Q54UJ0", "DDB_G0281051", "Q54DM7", "DDB_G0292122", "Q54NQ0", "DDB_G0285105", "P34118", "DDB_G0269156", "Q86IJ1", "DDB_G0272566", "Q54QR2", "DDB_G0283679", "Q54BC6", "DDB_G0293752", "Q1ZXD3", "DDB_G0288621", "P54651", "DDB_G0267400", "Q55C75", "DDB_G0270188", "P36415", "DDB_G0269144", "Q54WI8", "DDB_G0279633", "Q54L24", "DDB_G0286945", "Q54K94", "DDB_G0287569", "Q00766", "DDB_G0281383", "Q556G3", "DDB_G0272632", "Q556P3", "DDB_G0273153", "Q55FF3", "DDB_G0268138", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q54VI4", "DDB_G0280317", "Q86CR9", "DDB_G0271096", "Q54QS3", "DDB_G0283661", "Q54LY5", "DDB_G0286303", "Q54MA9", "DDB_G0286069", "Q54W35", "DDB_G0279909", "Q55C24", "DDB_G0270260", "Q54DD0", "DDB_G0292266", "O96626", "DDB_G0288319", "Q86A67", "DDB_G0274375", "Q54I79", "DDB_G0288937", "Q54QQ0", "DDB_G0283701", "Q55FM7", "DDB_G0268034", "Q552J0", "DDB_G0276233", "Q54E35", "DDB_G0291840", "Q55EK9", "DDB_G0268628", "Q6TMK4", "DDB_G0277275", "P90532", "DDB_G0288065", "Q54NE6", "DDB_G0285311", "Q556L1", "DDB_G0272590", "Q555L5", "DDB_G0274859", "Q54PN7", "DDB_G0284415", "B0G198", "DDB_G0295683", "Q54UQ2", "DDB_G0280897", "Q5V9E9", "DDB_G0283673", "Q6UK63", "DDB_G0287855", "Q54NT2", "DDB_G0284997", "Q54IA6", "DDB_G0288895", "Q75JR2", "DDB_G0272210", "C7G028", "DDB_G0284307", "Q54PF1", "DDB_G0284601", "O77229", "DDB_G0274595", "Q86KD1", "DDB_G0274167", "Q54I82", "DDB_G0288933", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q5R1U3", "DDB_G0277001", "Q556T3", "DDB_G0273107", "Q54RF5", "DDB_G0283247" ] }, "reaction_10614349": { "compartment": "compartment_876", "id": "reaction_10614349", "reactome": "R-DDI-6798743", "name": "Exocytosis of secretory granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614243" ], "products": [ "species_10614347" ], "modifiers": [], "additional_components": [ "Q54YP0", "DDB_G0278613", "Q559U0", "DDB_G0278613", "Q54K32", "DDB_G0287585", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "P34144", "DDB_G0277869", "Q86KI1", "DDB_G0273439", "Q54GY8", "DDB_G0289827", "Q54CM5", "DDB_G0292814", "Q23924", "DDB_G0284735", "Q54DG1", "DDB_G0292270", "Q8MYF2", "DDB_G0277441", "Q55FU9", "DDB_G0268402", "Q54RY4", "DDB_G0282899", "P20790", "DDB_G0280043", "P20791", "DDB_G0276399", "Q1ZXE7", "DDB_G0286169", "Q8T6J2", "DDB_G0274119", "Q8T6J5", "DDB_G0267438", "Q54BT5", "DDB_G0293436", "Q555Z5", "DDB_G0274121", "Q55BC0", "DDB_G0271138", "Q8T5Z7", "DDB_G0291994", "Q8T6J1", "DDB_G0291245", "Q54LZ3", "DDB_G0286293", "Q54E04", "DDB_G0291858", "Q54DA7", "DDB_G0292406", "Q54CI8", "DDB_G0292904", "Q86JP3", "DDB_G0271984", "Q869Q3", "DDB_G0274519", "Q55FK2", "DDB_G0268068", "P36411", "DDB_G0269236", "Q557I4", "DDB_G0273419", "Q55CT4", "DDB_G0270994", "Q55CY7", "DDB_G0270670", "P34138", "DDB_G0277865", "Q54FK4", "DDB_G0290833", "Q54FK8", "DDB_G0290829", "Q1ZXB8", "DDB_G0294571", "Q54K69", "DDB_G0287553", "Q1ZXB9", "DDB_G0290831", "Q54FK5", "DDB_G0290789", "Q54FK7", "DDB_G0290779", "Q552H0", "DDB_G0294571", "Q1ZXB7", "DDB_G0290791", "Q54FK2", "DDB_G0290793", "Q54K32", "DDB_G0287585", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "Q23924", "DDB_G0284735", "Q54GY8", "DDB_G0289827", "Q54E04", "DDB_G0291858", "Q8MYF2", "DDB_G0277441", "Q54CI8", "DDB_G0292904", "Q55FU9", "DDB_G0268402", "P34138", "DDB_G0277865", "Q86KI1", "DDB_G0273439", "Q869Q3", "DDB_G0274519", "Q54DG1", "DDB_G0292270", "Q54RY4", "DDB_G0282899", "P20790", "DDB_G0280043", "P20791", "DDB_G0276399", "Q1ZXE7", "DDB_G0286169", "Q54DA7", "DDB_G0292406", "Q54LZ3", "DDB_G0286293", "Q86JP3", "DDB_G0271984", "Q55FK2", "DDB_G0268068", "P36411", "DDB_G0269236", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q55CY7", "DDB_G0270670", "Q557I4", "DDB_G0273419", "Q55CT4", "DDB_G0270994", "Q8T6J2", "DDB_G0274119", "Q8T6J5", "DDB_G0267438", "Q54BT5", "DDB_G0293436", "Q555Z5", "DDB_G0274121", "Q55BC0", "DDB_G0271138", "Q8T5Z7", "DDB_G0291994", "Q8T6J1", "DDB_G0291245", "Q54YP0", "DDB_G0278613", "Q559U0", "DDB_G0278613", "Q54CM5", "DDB_G0292814", "P34144", "DDB_G0277869", "Q54FK5", "DDB_G0290789", "Q54FK7", "DDB_G0290779", "Q54FK8", "DDB_G0290829", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "Q1ZXB8", "DDB_G0294571", "Q552H0", "DDB_G0294571", "Q1ZXB9", "DDB_G0290831", "Q54FK2", "DDB_G0290793", "Q54FK4", "DDB_G0290833" ] }, "reaction_10614542": { "compartment": "compartment_6800173", "id": "reaction_10614542", "reactome": "R-DDI-6798745", "name": "Exocytosis of tertiary granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614462" ], "products": [ "species_10614540" ], "modifiers": [], "additional_components": [ "Q55FR5", "DDB_G0267990", "Q54JM9", "DDB_G0287939", "Q54XV8", "DDB_G0278563", "Q8MML4", "DDB_G0274551", "Q54F36", "DDB_G0291137", "Q54HL4", "DDB_G0289365", "O76856", "DDB_G0279411", "Q54RQ2", "DDB_G0282991", "Q54TR1", "DDB_G0281605", "Q54UH2", "DDB_G0282991", "Q54UH3", "DDB_G0282991", "Q86KD4", "DDB_G0282991", "P04989", "DDB_G0279799", "Q23894", "DDB_G0283867", "Q54RX2", "DDB_G0282859", "Q6UK63", "DDB_G0287855", "Q5R1U3", "DDB_G0277001", "Q75JR2", "DDB_G0272210", "Q55D97", "DDB_G0270626", "Q54I82", "DDB_G0288933", "B0G198", "DDB_G0295683", "Q86A67", "DDB_G0274375", "P05095", "DDB_G0268632", "Q54V78", "DDB_G0280565", "Q54B14", "DDB_G0293986", "Q550I3", "DDB_G0277093", "Q23919", "DDB_G0288483", "P52922", "DDB_G0269148", "Q6UK63", "DDB_G0287855", "Q54F36", "DDB_G0291137", "Q54XV8", "DDB_G0278563", "Q8MML4", "DDB_G0274551", "Q550I3", "DDB_G0277093", "Q75JR2", "DDB_G0272210", "Q54B14", "DDB_G0293986", "Q54UH2", "DDB_G0282991", "Q54UH3", "DDB_G0282991", "Q86KD4", "DDB_G0282991", "P04989", "DDB_G0279799", "Q23894", "DDB_G0283867", "Q54RQ2", "DDB_G0282991", "Q54TR1", "DDB_G0281605", "P05095", "DDB_G0268632", "Q54V78", "DDB_G0280565", "Q55FR5", "DDB_G0267990", "P52922", "DDB_G0269148", "Q54JM9", "DDB_G0287939", "Q23919", "DDB_G0288483", "Q54RX2", "DDB_G0282859", "Q54HL4", "DDB_G0289365", "Q86A67", "DDB_G0274375", "Q55D97", "DDB_G0270626", "Q54I82", "DDB_G0288933", "Q5R1U3", "DDB_G0277001", "O76856", "DDB_G0279411", "B0G198", "DDB_G0295683" ] }, "reaction_10612848": { "compartment": "compartment_21994", "id": "reaction_10612848", "reactome": "R-DDI-6789031", "name": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1222719", "species_6788973", "species_1470067" ], "products": [ "species_1222475", "species_6789150" ], "modifiers": [ [ "species_10612845", "catalyst" ] ], "additional_components": [ "Q6TMK4", "DDB_G0277275", "CHEBI:55376" ] }, "reaction_10612851": { "compartment": "compartment_1222282", "id": "reaction_10612851", "reactome": "R-DDI-6789126", "name": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1222719", "species_6788973", "species_1470067" ], "products": [ "species_1222475", "species_6789150" ], "modifiers": [ [ "species_10612843", "catalyst" ] ], "additional_components": [ "Q6TMK4", "DDB_G0277275", "CHEBI:55376" ] }, "reaction_10612853": { "compartment": "compartment_21994", "id": "reaction_10612853", "reactome": "R-DDI-6789136", "name": "Myeloperoxidase (MPO) binds to the bacterial cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612843", "species_983438" ], "products": [ "species_10612845" ], "modifiers": [], "additional_components": [ "Q6TMK4", "DDB_G0277275", "CHEBI:55376", "Q6TMK4", "DDB_G0277275", "CHEBI:55376" ] }, "reaction_10622909": { "compartment": "compartment_1222282", "id": "reaction_10622909", "reactome": "R-DDI-8933635", "name": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1222719", "species_1470067", "species_6789221" ], "products": [ "species_8933637", "species_1222475" ], "modifiers": [ [ "species_10612843", "catalyst" ] ], "additional_components": [ "Q6TMK4", "DDB_G0277275", "CHEBI:55376" ] }, "reaction_10619501": { "compartment": "compartment_984", "id": "reaction_10619501", "reactome": "R-DDI-8855490", "name": "Lactoperoxidase (LPO) produces OSCN-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351629", "species_8855492" ], "products": [ "species_109276", "species_8855489" ], "modifiers": [ [ "species_10619498", "catalyst" ] ], "additional_components": [ "Q6TMK4", "DDB_G0277275", "CHEBI:55376" ] }, "reaction_10597227": { "compartment": "compartment_1222693", "id": "reaction_10597227", "reactome": "R-DDI-1222516", "name": "Intraphagosomal pH is lowered to 5 by V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106" ], "products": [ "species_1470067" ], "modifiers": [ [ "species_10597224", "catalyst" ] ], "additional_components": [ "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q55AH5", "DDB_G0271882", "Q86A77", "DDB_G0274331", "O00780", "DDB_G0275701", "Q54Z13", "DDB_G0277971", "Q76NU1", "DDB_G0277401", "P54648", "DDB_G0284473", "Q54E04", "DDB_G0291858", "Q86AS7", "DDB_G0274141", "P54642", "DDB_G0274381", "P54641", "DDB_G0273071" ] }, "reaction_10593221": { "compartment": "compartment_70101", "id": "reaction_10593221", "reactome": "R-DDI-450400", "name": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593206", "species_450597", "species_10593217" ], "products": [ "species_10593219" ], "modifiers": [], "additional_components": [ "DDB_G0269948", "DDB_G0285973", "Q54MG5", "DDB_G0285973", "Q55CQ7", "DDB_G0269948" ] }, "reaction_10593230": { "compartment": "compartment_70101", "id": "reaction_10593230", "reactome": "R-DDI-450431", "name": "ZFP36 (TTP) recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593226", "species_10591881", "species_10591977", "species_10591874", "species_10593219" ], "products": [ "species_10593228" ], "modifiers": [], "additional_components": [ "DDB_G0289921", "DDB_G0283315", "Q55BJ2", "DDB_G0271100", "Q54VM4", "DDB_G0280251", "Q54CU6", "DDB_G0292692", "Q55BB0", "DDB_G0271396", "Q54EU6", "DDB_G0291328", "Q54Q83", "DDB_G0284053", "Q54EV5", "DDB_G0291310", "Q54N99", "DDB_G0285377", "Q54BH9", "DDB_G0293614", "Q7KWX9", "DDB_G0276783", "DDB_G0287243", "Q54MG5", "DDB_G0285973", "Q55CQ7", "DDB_G0269948", "Q54MG5", "DDB_G0285973", "Q55CQ7", "DDB_G0269948", "Q54KM1", "DDB_G0287243", "Q55BJ2", "DDB_G0271100", "Q54VM4", "DDB_G0280251", "Q54CU6", "DDB_G0292692", "Q55BB0", "DDB_G0271396", "Q54EU6", "DDB_G0291328", "Q54Q83", "DDB_G0284053", "Q54EV5", "DDB_G0291310", "Q54N99", "DDB_G0285377", "Q54BH9", "DDB_G0293614", "Q7KWX9", "DDB_G0276783", "Q54R87", "DDB_G0283315", "Q54GU2", "DDB_G0289921" ] }, "reaction_10602772": { "compartment": "compartment_70101", "id": "reaction_10602772", "reactome": "R-DDI-3371435", "name": "Constitutive phosphorylation by GSK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10602761" ], "products": [ "species_10602764", "species_29370" ], "modifiers": [ [ "species_10602769", "catalyst" ] ], "additional_components": [ "DDB_G0281165", "DDB_G0281165", "DDB_G0272110" ] }, "reaction_10602840": { "compartment": "compartment_7660", "id": "reaction_10602840", "reactome": "R-DDI-3371567", "name": "DBC1 is phosphorylated by ATM/ART", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10602832" ], "products": [ "species_113582", "species_10602826" ], "modifiers": [ [ "species_10602837", "catalyst" ] ], "additional_components": [ "DDB_G0274577", "DDB_G0274577", "DDB_G0291380" ] }, "reaction_10602830": { "compartment": "compartment_7660", "id": "reaction_10602830", "reactome": "R-DDI-3371537", "name": "DBC1 binds SIRT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602826", "species_10591478" ], "products": [ "species_10602828" ], "modifiers": [], "additional_components": [ "DDB_G0274577", "DDB_G0289967", "Q54GV7", "DDB_G0289967", "Q86A78", "DDB_G0274577" ] }, "reaction_10602865": { "compartment": "compartment_70101", "id": "reaction_10602865", "reactome": "R-DDI-3371591", "name": "Trimerization of cytosolic HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602761" ], "products": [ "species_10602814" ], "modifiers": [ [ "species_10583736", "catalyst" ] ], "additional_components": [ "DDB_G0281165", "Q54UC1", "DDB_G0281165", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136" ] }, "reaction_10605045": { "compartment": "compartment_70101", "id": "reaction_10605045", "reactome": "R-DDI-5324632", "name": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5324631", "species_10605040" ], "products": [ "species_10602761", "species_10589012", "species_10605042", "species_10602802" ], "modifiers": [ [ "species_10605040", "catalyst" ] ], "additional_components": [ "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "Q54UC1", "DDB_G0281165", "Q54X15", "DDB_G0279267", "P90532", "DDB_G0288065", "DDB_G0281165", "DDB_G0268042", "Q54X15", "DDB_G0279267", "P90532", "DDB_G0288065", "P54651", "DDB_G0267400", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "Q54UC1", "DDB_G0281165", "Q54X15", "DDB_G0279267", "P90532", "DDB_G0288065" ] }, "reaction_10602820": { "compartment": "compartment_70101", "id": "reaction_10602820", "reactome": "R-DDI-3371527", "name": "HSF1 trimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602814" ], "products": [ "species_10602818" ], "modifiers": [], "additional_components": [ "Q54UC1", "DDB_G0281165", "Q54UC1", "DDB_G0281165" ] }, "reaction_10602857": { "compartment": "compartment_70101", "id": "reaction_10602857", "reactome": "R-DDI-3371586", "name": "Dissociation of cytosolic HSF1:HSP90 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602855" ], "products": [ "species_10602761", "species_10589012", "species_10602802" ], "modifiers": [], "additional_components": [ "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "Q54UC1", "DDB_G0281165", "DDB_G0281165", "DDB_G0268042", "P54651", "DDB_G0267400" ] }, "reaction_10604376": { "compartment": "compartment_7660", "id": "reaction_10604376", "reactome": "R-DDI-5082409", "name": "Dissociation of HSF1:HSP90 complex in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604374" ], "products": [ "species_10604366", "species_10604347", "species_10604372" ], "modifiers": [], "additional_components": [ "P54651", "DDB_G0267400", "Q54UC1", "DDB_G0281165", "Q55FM3", "DDB_G0268042", "DDB_G0268042", "DDB_G0281165", "P54651", "DDB_G0267400" ] }, "reaction_10604349": { "compartment": "compartment_7660", "id": "reaction_10604349", "reactome": "R-DDI-5082391", "name": "Trimerization of HSF1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604347" ], "products": [ "species_10602818" ], "modifiers": [], "additional_components": [ "DDB_G0281165", "Q54UC1", "DDB_G0281165" ] }, "reaction_10582483": { "compartment": "compartment_7660", "id": "reaction_10582483", "reactome": "R-DDI-77590", "name": "Recruitment of CstF to the CPSF Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582477", "species_10579555" ], "products": [ "species_10582481" ], "modifiers": [], "additional_components": [ "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q55BS1", "DDB_G0270392", "Q55CA3", "DDB_G0270148", "Q54PX4", "DDB_G0284319", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797", "C7G084", "DDB_G0295793", "Q54TS6", "DDB_G0281585", "Q54V94", "DDB_G0280529", "Q54XS9", "DDB_G0278769", "Q54LG7", "DDB_G0286645", "Q54V94", "DDB_G0280529", "Q54XS9", "DDB_G0278769", "Q54LG7", "DDB_G0286645", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q55BS1", "DDB_G0270392", "Q55CA3", "DDB_G0270148", "Q54PX4", "DDB_G0284319", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797", "C7G084", "DDB_G0295793", "Q54TS6", "DDB_G0281585" ] }, "reaction_10582479": { "compartment": "compartment_7660", "id": "reaction_10582479", "reactome": "R-DDI-77589", "name": "Recognition of AAUAAA sequence by CPSF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10579534", "species_10582475" ], "products": [ "species_10582477" ], "modifiers": [], "additional_components": [ "Q55BS1", "DDB_G0270392", "Q55CA3", "DDB_G0270148", "Q54PX4", "DDB_G0284319", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797", "C7G084", "DDB_G0295793", "Q54TS6", "DDB_G0281585", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q55BS1", "DDB_G0270392", "Q55CA3", "DDB_G0270148", "Q54PX4", "DDB_G0284319", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797", "C7G084", "DDB_G0295793", "Q54TS6", "DDB_G0281585" ] }, "reaction_10601473": { "compartment": "compartment_70101", "id": "reaction_10601473", "reactome": "R-DDI-2586748", "name": "GUCA binds Ca2+ to form GUCA:Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581368", "species_74016" ], "products": [ "species_10581380" ], "modifiers": [], "additional_components": [ "DDB_G0275931", "species_74112", "Q75K28", "DDB_G0275931" ] }, "reaction_10601385": { "compartment": "compartment_70101", "id": "reaction_10601385", "reactome": "R-DDI-2534087", "name": "NMT1/2 transfer MYS to GNAT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601375", "species_2534019" ], "products": [ "species_10581129", "species_76194" ], "modifiers": [ [ "species_10601380", "catalyst" ] ], "additional_components": [ "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "Q54VG1", "DDB_G0280351", "P16051", "DDB_G0276267", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "DDB_G0275863" ] }, "reaction_10601432": { "compartment": "compartment_70101", "id": "reaction_10601432", "reactome": "R-DDI-2534096", "name": "METAP1/2 demethylates GNAT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601413" ], "products": [ "species_10601375", "species_174390" ], "modifiers": [ [ "species_10601429", "catalyst" ] ], "additional_components": [ "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "Q55C21", "DDB_G0270264", "species_880069", "Q54WU3", "DDB_G0279433" ] }, "reaction_10581390": { "compartment": "compartment_2514888", "id": "reaction_10581390", "reactome": "R-DDI-74885", "name": "GUCYs converts GTP to cGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438" ], "products": [ "species_111294", "species_30991" ], "modifiers": [ [ "species_10581362", "catalyst" ], [ "species_10581382", "catalyst" ], [ "species_10581384", "catalyst" ], [ "species_10581380", "inhibitor" ], [ "species_10581386", "inhibitor" ], [ "species_10581388", "inhibitor" ] ], "additional_components": [ "Q03101", "DDB_G0274569", "Q553Y7", "DDB_G0275009", "DDB_G0275931", "DDB_G0275931", "species_74112", "Q75K28", "DDB_G0275931", "species_74112", "Q75K28", "DDB_G0275931", "species_74112", "Q75K28", "DDB_G0275931" ] }, "reaction_10591906": { "compartment": "compartment_70101", "id": "reaction_10591906", "reactome": "R-DDI-429978", "name": "Lsm1-7 Complex binds deadenylated mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10591863", "species_429974" ], "products": [ "species_10591865" ], "modifiers": [], "additional_components": [ "Q54HF6", "DDB_G0289499", "Q55F60", "DDB_G0268244", "Q54W83", "DDB_G0279837", "Q1ZXK3", "DDB_G0277107", "Q54KX4", "DDB_G0287053", "Q55EX5", "DDB_G0268716", "Q552U1", "DDB_G0275719", "Q54TF6", "DDB_G0281779", "Q54HF6", "DDB_G0289499", "Q55F60", "DDB_G0268244", "Q54W83", "DDB_G0279837", "Q1ZXK3", "DDB_G0277107", "Q54KX4", "DDB_G0287053", "Q55EX5", "DDB_G0268716", "Q552U1", "DDB_G0275719", "Q54TF6", "DDB_G0281779" ] }, "reaction_10591896": { "compartment": "compartment_70101", "id": "reaction_10591896", "reactome": "R-DDI-429860", "name": "DCP1-DCP2 complex decaps mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10591865" ], "products": [ "species_10591867", "species_430004" ], "modifiers": [ [ "species_10591893", "catalyst" ] ], "additional_components": [ "Q54HF6", "DDB_G0289499", "Q55F60", "DDB_G0268244", "Q54W83", "DDB_G0279837", "Q1ZXK3", "DDB_G0277107", "Q54KX4", "DDB_G0287053", "Q55EX5", "DDB_G0268716", "Q552U1", "DDB_G0275719", "Q54TF6", "DDB_G0281779", "Q54HF6", "DDB_G0289499", "Q55F60", "DDB_G0268244", "Q54W83", "DDB_G0279837", "Q1ZXK3", "DDB_G0277107", "Q54KX4", "DDB_G0287053", "Q55EX5", "DDB_G0268716", "Q552U1", "DDB_G0275719", "Q54TF6", "DDB_G0281779", "Q54E49", "DDB_G0291804", "Q54KM1", "DDB_G0287243", "Q54R87", "DDB_G0283315", "Q54J96", "DDB_G0288241" ] }, "reaction_10589052": { "compartment": "compartment_984", "id": "reaction_10589052", "reactome": "R-DDI-265456", "name": "NPC1L1 inactivation by ezetimibe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589048", "species_265479" ], "products": [ "species_10589050" ], "modifiers": [], "additional_components": [ "Q551C5", "DDB_G0276657", "Q9TVK6", "DDB_G0269158", "species_265479", "Q551C5", "DDB_G0276657", "Q9TVK6", "DDB_G0269158" ] }, "reaction_10619411": { "compartment": "compartment_17938", "id": "reaction_10619411", "reactome": "R-DDI-8854329", "name": "TBC1D15 accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10619394" ], "products": [ "species_29372", "species_10619396" ], "modifiers": [ [ "species_10619394", "catalyst" ], [ "species_10619409", "catalyst" ] ], "additional_components": [ "species_29438", "P36411", "DDB_G0269236", "Q54FK4", "DDB_G0290833", "Q54FK2", "DDB_G0290793", "Q54FK7", "DDB_G0290779", "Q54FK5", "DDB_G0290789", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "Q54FK8", "DDB_G0290829", "Q1ZXB9", "DDB_G0290831", "Q1ZXB8", "DDB_G0294571", "Q552H0", "DDB_G0294571", "P36411", "DDB_G0269236", "Q54FK4", "DDB_G0290833", "Q54FK2", "DDB_G0290793", "Q54FK7", "DDB_G0290779", "Q54FK5", "DDB_G0290789", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "Q54FK8", "DDB_G0290829", "Q1ZXB9", "DDB_G0290831", "Q1ZXB8", "DDB_G0294571", "Q552H0", "DDB_G0294571", "species_29420", "species_29438", "P36411", "DDB_G0269236", "Q54FK4", "DDB_G0290833", "Q54FK2", "DDB_G0290793", "Q54FK7", "DDB_G0290779", "Q54FK5", "DDB_G0290789", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "Q54FK8", "DDB_G0290829", "Q1ZXB9", "DDB_G0290831", "Q1ZXB8", "DDB_G0294571", "Q552H0", "DDB_G0294571", "Q54IE1", "DDB_G0288811", "Q54UD8", "DDB_G0288811" ] }, "reaction_10619424": { "compartment": "compartment_5683628", "id": "reaction_10619424", "reactome": "R-DDI-8854588", "name": "TBC1D25 (OATL1) binds ATG8 homologues", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619420", "species_10619414" ], "products": [ "species_10619422" ], "modifiers": [], "additional_components": [ "Q54UD8", "DDB_G0288811", "Q54IE1", "DDB_G0288811", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q54UD8", "DDB_G0288811", "Q54IE1", "DDB_G0288811" ] }, "reaction_10619313": { "compartment": "compartment_19363", "id": "reaction_10619313", "reactome": "R-DDI-8854209", "name": "TBC1D10A binds JFC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619309", "species_10619303" ], "products": [ "species_10619311" ], "modifiers": [], "additional_components": [ "Q54Z16", "DDB_G0289735", "Q54H32", "DDB_G0289735", "DDB_G0282977", "Q54RR0", "DDB_G0282977", "Q54Z16", "DDB_G0289735", "Q54H32", "DDB_G0289735" ] }, "reaction_10619441": { "compartment": "compartment_437051", "id": "reaction_10619441", "reactome": "R-DDI-8854604", "name": "TBC1D16 accelerates GTP hydrolysis by RAB4A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10619430" ], "products": [ "species_29372", "species_10619432" ], "modifiers": [ [ "species_10619430", "catalyst" ], [ "species_10619439", "catalyst" ] ], "additional_components": [ "Q54DA7", "DDB_G0292406", "species_29438", "Q54DA7", "DDB_G0292406", "species_29420", "Q54DA7", "DDB_G0292406", "species_29438", "Q54IE1", "DDB_G0288811", "Q54UD8", "DDB_G0288811" ] }, "reaction_10619366": { "compartment": "compartment_20699", "id": "reaction_10619366", "reactome": "R-DDI-8854303", "name": "TBC1D11 binds RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618515", "species_10619362" ], "products": [ "species_10619364" ], "modifiers": [], "additional_components": [ "Q55FK2", "DDB_G0268068", "species_29438", "DDB_G0290597", "Q54FT8", "DDB_G0290597", "Q55FK2", "DDB_G0268068", "species_29438" ] }, "reaction_10619478": { "compartment": "compartment_262783", "id": "reaction_10619478", "reactome": "R-DDI-8854759", "name": "TBC1D14 binds RAB11 and ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619469", "species_10619467", "species_10619474" ], "products": [ "species_10619476" ], "modifiers": [], "additional_components": [ "DDB_G0292390", "P36412", "DDB_G0269238", "Q86JP0", "DDB_G0294583", "DDB_G0269130", "O96904", "DDB_G0269130", "P36412", "DDB_G0269238", "Q86JP0", "DDB_G0294583", "Q86CS2", "DDB_G0292390" ] }, "reaction_10619300": { "compartment": "compartment_24339", "id": "reaction_10619300", "reactome": "R-DDI-8854173", "name": "TBC RabGAPs accelerate GTP hydrolysis by RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10619265" ], "products": [ "species_29372", "species_10619267" ], "modifiers": [ [ "species_10619265", "catalyst" ], [ "species_10619298", "catalyst" ] ], "additional_components": [ "Q54FL2", "DDB_G0290783", "species_29438", "species_29420", "Q54FL2", "DDB_G0290783", "Q54FL2", "DDB_G0290783", "species_29438", "Q54Z16", "DDB_G0289735", "Q54H32", "DDB_G0289735", "Q54CG7", "DDB_G0292932", "Q55F14", "DDB_G0269052" ] }, "reaction_10619352": { "compartment": "compartment_262783", "id": "reaction_10619352", "reactome": "R-DDI-8854293", "name": "TBC1D10A (EPI64) binds ARF6:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619309", "species_10619348" ], "products": [ "species_10619350" ], "modifiers": [], "additional_components": [ "Q54Z16", "DDB_G0289735", "Q54H32", "DDB_G0289735", "Q554Y8", "DDB_G0274445", "species_29438", "Q554Y8", "DDB_G0274445", "species_29438", "Q54Z16", "DDB_G0289735", "Q54H32", "DDB_G0289735" ] }, "reaction_10619340": { "compartment": "compartment_17938", "id": "reaction_10619340", "reactome": "R-DDI-8854255", "name": "TBC1D2A accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10619323" ], "products": [ "species_10619325", "species_29372" ], "modifiers": [ [ "species_10619323", "catalyst" ], [ "species_10619338", "catalyst" ] ], "additional_components": [ "species_29438", "P36411", "DDB_G0269236", "P36411", "DDB_G0269236", "species_29420", "species_29438", "P36411", "DDB_G0269236", "Q553Q2", "DDB_G0295717", "C7G032", "DDB_G0295717", "Q55E78", "DDB_G0295717", "Q553U1", "DDB_G0295717", "Q75JG4", "DDB_G0276119" ] }, "reaction_10619453": { "compartment": "compartment_5683628", "id": "reaction_10619453", "reactome": "R-DDI-8854612", "name": "TBC1D25 accelerates GTP hydrolysis by RAB33B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10619448" ], "products": [ "species_29372", "species_10619450" ], "modifiers": [ [ "species_10619448", "catalyst" ], [ "species_10619420", "catalyst" ] ], "additional_components": [ "O76173", "DDB_G0269174", "species_29438", "O76173", "DDB_G0269174", "species_29420", "O76173", "DDB_G0269174", "species_29438", "Q54UD8", "DDB_G0288811", "Q54IE1", "DDB_G0288811" ] }, "reaction_10594836": { "compartment": "compartment_70101", "id": "reaction_10594836", "reactome": "R-DDI-917696", "name": "Cargo Sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594815", "species_10594832" ], "products": [ "species_10594813", "species_10594834" ], "modifiers": [], "additional_components": [ "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P14797", "DDB_G0276765", "species_179838", "Q55DV8", "DDB_G0269510", "Q54NF1", "DDB_G0285295", "Q54LJ3", "DDB_G0286797", "Q54RC4", "DDB_G0283203", "Q55GD9", "DDB_G0267708", "Q54T18", "DDB_G0282045", "Q55DV8", "DDB_G0269510", "Q54NF1", "DDB_G0285295", "Q54LJ3", "DDB_G0286797", "Q54RC4", "DDB_G0283203", "Q55GD9", "DDB_G0267708", "Q54T18", "DDB_G0282045", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P14797", "DDB_G0276765", "species_179838" ] }, "reaction_10594788": { "compartment": "compartment_74700", "id": "reaction_10594788", "reactome": "R-DDI-917693", "name": "ESCRT Disassembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10594631" ], "products": [ "species_29372", "species_10594475", "species_29370", "species_10594489", "species_10594470", "species_10594484", "species_10594769", "species_10594465" ], "modifiers": [ [ "species_10594785", "catalyst" ] ], "additional_components": [ "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P14797", "DDB_G0276765", "species_179838", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54P63", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q86H98", "DDB_G0275573", "DDB_G0275573", "DDB_G0287993", "DDB_G0284769", "DDB_G0287021", "species_179838", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0290087", "Q54PT2", "DDB_G0284347", "Q54JK4", "DDB_G0287993", "Q55B11", "DDB_G0271488" ] }, "reaction_10594838": { "compartment": "compartment_70101", "id": "reaction_10594838", "reactome": "R-DDI-917700", "name": "MVB Vesicle Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594491", "species_10594834" ], "products": [ "species_10594631", "species_10594832" ], "modifiers": [], "additional_components": [ "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54P63", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q86H98", "DDB_G0275573", "Q54RC4", "DDB_G0283203", "Q55GD9", "DDB_G0267708", "Q54T18", "DDB_G0282045", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P14797", "DDB_G0276765", "species_179838", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P14797", "DDB_G0276765", "species_179838", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54P63", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q86H98", "DDB_G0275573", "Q54RC4", "DDB_G0283203", "Q55GD9", "DDB_G0267708", "Q54T18", "DDB_G0282045" ] }, "reaction_10611220": { "compartment": "compartment_70101", "id": "reaction_10611220", "reactome": "R-DDI-5691131", "name": "CANDI binds CUL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585421", "species_10611216" ], "products": [ "species_10611218" ], "modifiers": [], "additional_components": [ "DDB_G0291972", "DDB_G0274167", "Q86KD1", "DDB_G0274167", "O60999", "DDB_G0291972" ] }, "reaction_10611211": { "compartment": "compartment_70101", "id": "reaction_10611211", "reactome": "R-DDI-5691108", "name": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611084", "species_10577037" ], "products": [ "species_10611202" ], "modifiers": [ [ "species_10611208", "catalyst" ] ], "additional_components": [ "DDB_G0279159", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0279159", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54XV3", "DDB_G0278711" ] }, "reaction_10611082": { "compartment": "compartment_70101", "id": "reaction_10611082", "reactome": "R-DDI-5690873", "name": "ACO1 binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690881", "species_10611078" ], "products": [ "species_10611080" ], "modifiers": [], "additional_components": [ "DDB_G0279159", "Q54X73", "DDB_G0279159" ] }, "reaction_10594848": { "compartment": "compartment_74700", "id": "reaction_10594848", "reactome": "R-DDI-917936", "name": "MCOLN1 transports Fe2+ from endosome lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_917810" ], "products": [ "species_71067" ], "modifiers": [ [ "species_10594845", "catalyst" ] ], "additional_components": [ "DDB_G0291275" ] }, "reaction_10594840": { "compartment": "compartment_74700", "id": "reaction_10594840", "reactome": "R-DDI-917841", "name": "Acidification of Tf:TfR1 containing endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_70106", "species_113592" ], "products": [ "species_29372", "species_29370", "species_74722" ], "modifiers": [ [ "species_10581339", "catalyst" ] ], "additional_components": [ "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q55AH5", "DDB_G0271882", "Q86A77", "DDB_G0274331", "O00780", "DDB_G0275701", "Q54Z13", "DDB_G0277971", "Q76NU1", "DDB_G0277401", "P54648", "DDB_G0284473", "P54641", "DDB_G0273071", "Q86AS7", "DDB_G0274141", "Q54E04", "DDB_G0291858", "P54642", "DDB_G0274381", "Q557I5", "DDB_G0273483" ] }, "reaction_10611087": { "compartment": "compartment_70101", "id": "reaction_10611087", "reactome": "R-DDI-5690911", "name": "ACO1:4Fe-4S isomerises CIT to ISCIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76190" ], "products": [ "species_389545" ], "modifiers": [ [ "species_10611080", "catalyst" ] ], "additional_components": [ "Q54X73", "DDB_G0279159" ] } }, "collapsed_reaction_dictionary": { "reaction_10584068": { "compartment": "compartment_7660", "id": "reaction_10584068", "reactome": "R-DDI-163733", "name": "Transcriptional activation of FAS monomer gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10581670" ], "modifiers": [], "additional_components": [ "Q869X2", "DDB_G0275077", "Q55E72", "DDB_G0269364", "Q869W9", "DDB_G0275069" ] }, "reaction_10584072": { "compartment": "compartment_7660", "id": "reaction_10584072", "reactome": "R-DDI-163743", "name": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10584070" ], "modifiers": [], "additional_components": [ "DDB_G0288387" ] }, "reaction_10584074": { "compartment": "compartment_7660", "id": "reaction_10584074", "reactome": "R-DDI-163748", "name": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10581684" ], "modifiers": [], "additional_components": [ "DDB_G0291332" ] }, "reaction_10601278": { "compartment": "compartment_984", "id": "reaction_10601278", "reactome": "R-DDI-2514772", "name": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600215" ], "products": [ "species_10601195" ], "modifiers": [ [ "species_10601275", "catalyst" ] ], "additional_components": [ "Q54IA3", "DDB_G0295485", "B0G154", "DDB_G0295485", "Q54IA3", "DDB_G0295485", "B0G154", "DDB_G0295485", "Q54TR1", "DDB_G0281605", "Q54UH2", "DDB_G0282991", "Q54UH3", "DDB_G0282991", "Q86KD4", "DDB_G0282991", "P04989", "DDB_G0279799", "Q23894", "DDB_G0283867", "Q54RQ2", "DDB_G0282991" ] }, "reaction_10603294": { "compartment": "compartment_984", "id": "reaction_10603294", "reactome": "R-DDI-3814820", "name": "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598295" ], "products": [ "species_10603257", "species_10603255" ], "modifiers": [ [ "species_10603291", "catalyst" ] ], "additional_components": [ "DDB_G0270488", "DDB_G0270488", "DDB_G0270488", "Q54TR1", "DDB_G0281605", "Q54UH2", "DDB_G0282991", "Q54UH3", "DDB_G0282991", "Q86KD4", "DDB_G0282991", "P04989", "DDB_G0279799", "Q23894", "DDB_G0283867", "Q54RQ2", "DDB_G0282991" ] }, "reaction_10594336": { "compartment": "compartment_13231", "id": "reaction_10594336", "reactome": "R-DDI-913529", "name": "Translocation of p-STAT1:p-STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594322" ], "products": [ "species_10594334" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167" ] }, "reaction_10597154": { "compartment": "compartment_70101", "id": "reaction_10597154", "reactome": "R-DDI-1169397", "name": "Activation of ISG15 by UBA7 E1 ligase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10595036", "species_113592", "species_10595029" ], "products": [ "species_111294", "species_10597151", "species_76577" ], "modifiers": [ [ "species_10595036", "catalyst" ] ], "additional_components": [ "DDB_G0270272", "DDB_G0292984", "Q54CI1", "DDB_G0292984", "Q55C16", "DDB_G0270272", "DDB_G0270272" ] }, "reaction_10597170": { "compartment": "compartment_70101", "id": "reaction_10597170", "reactome": "R-DDI-1169404", "name": "Transfer of ISG15 from E1 to E2 (UBCH8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597151", "species_10595031" ], "products": [ "species_10595036", "species_10597143" ], "modifiers": [ [ "species_10595031", "catalyst" ] ], "additional_components": [ "Q54CI1", "DDB_G0292984", "Q55C16", "DDB_G0270272", "DDB_G0281833", "DDB_G0270272", "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "DDB_G0281833" ] }, "reaction_10597158": { "compartment": "compartment_70101", "id": "reaction_10597158", "reactome": "R-DDI-1169399", "name": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596135", "species_10595029" ], "products": [ "species_10597156" ], "modifiers": [], "additional_components": [ "C7G034", "DDB_G0285063", "Q54QF1", "DDB_G0283983", "DDB_G0292984", "Q54CI1", "DDB_G0292984", "C7G034", "DDB_G0285063", "Q54QF1", "DDB_G0283983" ] }, "reaction_10599224": { "compartment": "compartment_70101", "id": "reaction_10599224", "reactome": "R-DDI-1678842", "name": "Competitive inhibition of translation initiation by ISGylated 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599208", "species_10599220" ], "products": [ "species_10599222", "species_10599218" ], "modifiers": [], "additional_components": [ "B0G0Z1", "DDB_G0284841", "Q54E38", "DDB_G0291820", "Q55BQ5", "DDB_G0284841", "Q54P37", "DDB_G0284841", "Q54T63", "DDB_G0284841", "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043", "Q55FE0", "DDB_G0268574", "Q54E38", "DDB_G0291820", "Q553R3", "DDB_G0275395", "Q55D61", "DDB_G0269192", "P90529", "DDB_G0269146", "B0G0Z1", "DDB_G0284841", "Q54E38", "DDB_G0291820", "Q55BQ5", "DDB_G0284841", "Q54P37", "DDB_G0284841", "Q54T63", "DDB_G0284841", "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043", "Q55FE0", "DDB_G0268574", "Q54E38", "DDB_G0291820", "Q553R3", "DDB_G0275395", "Q55D61", "DDB_G0269192", "P90529", "DDB_G0269146" ] }, "reaction_10597192": { "compartment": "compartment_70101", "id": "reaction_10597192", "reactome": "R-DDI-1169406", "name": "ISGylation of host proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597149", "species_113592", "species_10597188" ], "products": [ "species_111294", "species_10597147", "species_10597190", "species_10595031", "species_76577" ], "modifiers": [ [ "species_10597149", "catalyst" ] ], "additional_components": [ "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q54TE1", "DDB_G0281833", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043", "Q54CI1", "DDB_G0292984", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q54TE1", "DDB_G0281833", "DDB_G0281833", "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043" ] }, "reaction_10599179": { "compartment": "compartment_70101", "id": "reaction_10599179", "reactome": "R-DDI-1678841", "name": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597190" ], "products": [ "species_10597188", "species_141681" ], "modifiers": [ [ "species_10599176", "catalyst" ] ], "additional_components": [ "Q54CI1", "DDB_G0292984", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q54TE1", "DDB_G0281833", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q54TE1", "DDB_G0281833", "Q54DT4", "DDB_G0292046", "Q553T4", "DDB_G0275415" ] }, "reaction_10599226": { "compartment": "compartment_70101", "id": "reaction_10599226", "reactome": "R-DDI-1678843", "name": "ISGylation of protein translation regulator 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597149", "species_10599206" ], "products": [ "species_10599208" ], "modifiers": [], "additional_components": [ "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043", "B0G0Z1", "DDB_G0284841", "Q54E38", "DDB_G0291820", "Q55BQ5", "DDB_G0284841", "Q54P37", "DDB_G0284841", "Q54T63", "DDB_G0284841", "B0G0Z1", "DDB_G0284841", "Q54E38", "DDB_G0291820", "Q55BQ5", "DDB_G0284841", "Q54P37", "DDB_G0284841", "Q54T63", "DDB_G0284841", "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043" ] }, "reaction_10597165": { "compartment": "compartment_70101", "id": "reaction_10597165", "reactome": "R-DDI-1169402", "name": "ISGylation of E2 conjugating enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597149", "species_113592", "species_10597160" ], "products": [ "species_111294", "species_10597162", "species_10597147", "species_10595031", "species_76577" ], "modifiers": [ [ "species_10597149", "catalyst" ] ], "additional_components": [ "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043", "Q86K32", "DDB_G0277267", "Q54TE1", "DDB_G0281833", "Q54CI1", "DDB_G0292984", "Q86K32", "DDB_G0277267", "Q54TE1", "DDB_G0281833", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043", "DDB_G0281833", "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043" ] }, "reaction_10597167": { "compartment": "compartment_70101", "id": "reaction_10597167", "reactome": "R-DDI-1169403", "name": "Interaction of E3 ligase with ISG15:E2 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597147", "species_10597143" ], "products": [ "species_10597149" ], "modifiers": [], "additional_components": [ "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043", "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043" ] }, "reaction_10594178": { "compartment": "compartment_13231", "id": "reaction_10594178", "reactome": "R-DDI-873917", "name": "Translocation of STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594164" ], "products": [ "species_10594176" ], "modifiers": [], "additional_components": [ "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167" ] }, "reaction_10594217": { "compartment": "compartment_7660", "id": "reaction_10594217", "reactome": "R-DDI-877281", "name": "PIAS1 binds p-STAT1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594201", "species_10594213", "species_10594176" ], "products": [ "species_10594215" ], "modifiers": [], "additional_components": [ "Q54V57", "DDB_G0280603", "Q555X5", "DDB_G0274743", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q54V57", "DDB_G0280603", "Q555X5", "DDB_G0274743" ] }, "reaction_10612656": { "compartment": "compartment_70101", "id": "reaction_10612656", "reactome": "R-DDI-6786293", "name": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612625" ], "products": [ "species_10612654" ], "modifiers": [], "additional_components": [ "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381" ] }, "reaction_10612627": { "compartment": "compartment_70101", "id": "reaction_10612627", "reactome": "R-DDI-6786097", "name": "p-Y705-STAT3, p-Y641-STAT6 dimerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612621" ], "products": [ "species_10612625" ], "modifiers": [], "additional_components": [ "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638" ] }, "reaction_10612900": { "compartment": "compartment_17957", "id": "reaction_10612900", "reactome": "R-DDI-6790038", "name": "Expression of HSP90B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10612898" ], "modifiers": [ [ "species_10597019", "catalyst" ] ], "additional_components": [ "DDB_G0280057", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381" ] }, "reaction_10612808": { "compartment": "compartment_70101", "id": "reaction_10612808", "reactome": "R-DDI-6788622", "name": "p-Y-STATs dimerize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612804" ], "products": [ "species_10612806" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167" ] }, "reaction_10612812": { "compartment": "compartment_70101", "id": "reaction_10612812", "reactome": "R-DDI-6788623", "name": "p-Y-STATs translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612806" ], "products": [ "species_10612810" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381" ] }, "reaction_10592978": { "compartment": "compartment_984", "id": "reaction_10592978", "reactome": "R-DDI-449117", "name": "TXLNA (IL14) binds syntaxin1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10592964", "species_10592962" ], "products": [ "species_10592966" ], "modifiers": [ [ "species_10592976", "inhibitor" ] ], "additional_components": [ "DDB_G0289379", "DDB_G0290231", "Q54GD1", "DDB_G0290231", "Q54HM5", "DDB_G0289379", "Q54HM5", "DDB_G0289379", "Q54QC8", "DDB_G0283937", "Q54ZW8", "DDB_G0277343", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590" ] }, "reaction_10624948": { "compartment": "compartment_984", "id": "reaction_10624948", "reactome": "R-DDI-9014052", "name": "TXLNA (IL14) binds syntaxin3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10592962", "species_10624944" ], "products": [ "species_10624946" ], "modifiers": [], "additional_components": [ "DDB_G0290231", "Q55DR2", "DDB_G0270556", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556", "Q54HM5", "DDB_G0289379", "Q54GD1", "DDB_G0290231" ] }, "reaction_10624952": { "compartment": "compartment_984", "id": "reaction_10624952", "reactome": "R-DDI-9014074", "name": "TXLNA (IL14) binds syntaxin4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589716", "species_10592962" ], "products": [ "species_10624950" ], "modifiers": [], "additional_components": [ "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556", "DDB_G0290231", "Q54GD1", "DDB_G0290231", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556" ] }, "reaction_10593044": { "compartment": "compartment_70101", "id": "reaction_10593044", "reactome": "R-DDI-450296", "name": "Phosphorylated MKK3/MKK6 migrates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593036" ], "products": [ "species_10593042" ], "modifiers": [], "additional_components": [ "Q54HS0", "DDB_G0289277", "Q54HS0", "DDB_G0289277" ] }, "reaction_10593080": { "compartment": "compartment_70101", "id": "reaction_10593080", "reactome": "R-DDI-450346", "name": "activated human TAK1 phosphorylates MKK3/MKK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10593078" ], "products": [ "species_10593036", "species_29370" ], "modifiers": [ [ "species_10593069", "catalyst" ] ], "additional_components": [ "Q54HS0", "DDB_G0289277", "Q54HS0", "DDB_G0289277", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54FC5", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "P11467", "DDB_G0290961", "Q1ZXR0", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54LU8", "DDB_G0286465" ] }, "reaction_10587141": { "compartment": "compartment_7660", "id": "reaction_10587141", "reactome": "R-DDI-198746", "name": "ERK1/2/5 activate RSK1/2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10587082" ], "products": [ "species_113582", "species_10587136" ], "modifiers": [ [ "species_10587138", "catalyst" ] ], "additional_components": [ "Q8MYF1", "DDB_G0277449", "P34102", "DDB_G0286125", "P34102", "DDB_G0286125", "Q8MYF1", "DDB_G0277449", "P42525", "DDB_G0286353" ] }, "reaction_10587284": { "compartment": "compartment_7660", "id": "reaction_10587284", "reactome": "R-DDI-199959", "name": "ERKs are inactivated by protein phosphatase 2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10587138" ], "products": [ "species_113550", "species_10587274" ], "modifiers": [ [ "species_10587281", "catalyst" ] ], "additional_components": [ "P42525", "DDB_G0286353", "P42525", "DDB_G0286353", "Q54VB6", "DDB_G0280469" ] }, "reaction_10587820": { "compartment": "compartment_7660", "id": "reaction_10587820", "reactome": "R-DDI-203797", "name": "ERKs are inactivated by dual-specific phosphatases (DUSPs)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10587138" ], "products": [ "species_113550", "species_10587274" ], "modifiers": [ [ "species_10587817", "catalyst" ] ], "additional_components": [ "P42525", "DDB_G0286353", "P42525", "DDB_G0286353", "Q55BI8", "DDB_G0285449", "Q54N84", "DDB_G0285449", "Q54Y32", "DDB_G0278445", "Q556Y8", "DDB_G0285449" ] }, "reaction_10593072": { "compartment": "compartment_70101", "id": "reaction_10593072", "reactome": "R-DDI-450337", "name": "Activated TAK1 phosphorylates MKK4/MKK7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593050", "species_113592" ], "products": [ "species_29370", "species_10593060" ], "modifiers": [ [ "species_10593069", "catalyst" ] ], "additional_components": [ "Q54HS0", "DDB_G0289277", "Q54HS0", "DDB_G0289277", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54FC5", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "P11467", "DDB_G0290961", "Q1ZXR0", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54LU8", "DDB_G0286465" ] }, "reaction_10624354": { "compartment": "compartment_70101", "id": "reaction_10624354", "reactome": "R-DDI-8983373", "name": "p-Y-STAT3 binds p-STAT5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624350", "species_10624340" ], "products": [ "species_10624352" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167" ] }, "reaction_10624388": { "compartment": "compartment_70101", "id": "reaction_10624388", "reactome": "R-DDI-8983379", "name": "p-Y-STAT3:p-STAT5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624352" ], "products": [ "species_10624386" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "Q54BD4", "DDB_G0293532", "O00910", "DDB_G0281381", "Q86I20", "DDB_G0275167", "Q70GP4", "DDB_G0268638" ] }, "reaction_10624407": { "compartment": "compartment_70101", "id": "reaction_10624407", "reactome": "R-DDI-8985943", "name": "p-Y701-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624403" ], "products": [ "species_10624405" ], "modifiers": [], "additional_components": [ "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532" ] }, "reaction_10624411": { "compartment": "compartment_70101", "id": "reaction_10624411", "reactome": "R-DDI-8985950", "name": "p-Y649-STAT5A, p-STAT5B dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624340" ], "products": [ "species_10624409" ], "modifiers": [], "additional_components": [] }, "reaction_10624415": { "compartment": "compartment_70101", "id": "reaction_10624415", "reactome": "R-DDI-8985966", "name": "p-Y701-STAT1 binds p-Y705-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624350", "species_10624403" ], "products": [ "species_10624413" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532" ] }, "reaction_10624429": { "compartment": "compartment_70101", "id": "reaction_10624429", "reactome": "R-DDI-8985981", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624413" ], "products": [ "species_10624427" ], "modifiers": [], "additional_components": [ "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q54BD4", "DDB_G0293532", "O00910", "DDB_G0281381", "Q86I20", "DDB_G0275167", "Q70GP4", "DDB_G0268638" ] }, "reaction_10597005": { "compartment": "compartment_70101", "id": "reaction_10597005", "reactome": "R-DDI-1112538", "name": "Phosphorylated STAT1, STAT3 form dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596997" ], "products": [ "species_10597003" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167" ] }, "reaction_10597023": { "compartment": "compartment_70101", "id": "reaction_10597023", "reactome": "R-DDI-1112587", "name": "STAT1 and STAT3 dimers translocate to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597003" ], "products": [ "species_10597021" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381" ] }, "reaction_10624538": { "compartment": "compartment_70101", "id": "reaction_10624538", "reactome": "R-DDI-9009072", "name": "STAT3 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10589922" ], "products": [ "species_10624350", "species_29370" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q86I20", "DDB_G0275167", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167" ] }, "reaction_10593345": { "compartment": "compartment_70101", "id": "reaction_10593345", "reactome": "R-DDI-451418", "name": "Pellino ubiquitinates IRAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593334" ], "products": [ "species_10593342" ], "modifiers": [ [ "species_10593334", "catalyst" ] ], "additional_components": [ "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54D06", "DDB_G0292596", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54LU8", "DDB_G0286465", "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54D06", "DDB_G0292596" ] }, "reaction_10593026": { "compartment": "compartment_70101", "id": "reaction_10593026", "reactome": "R-DDI-450173", "name": "IRAK1 induces oligomerisation of TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10592841", "species_10584497" ], "products": [ "species_10592843" ], "modifiers": [], "additional_components": [ "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54LU8", "DDB_G0286465" ] }, "reaction_10623333": { "compartment": "compartment_70101", "id": "reaction_10623333", "reactome": "R-DDI-8948015", "name": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10592847" ], "products": [ "species_10592919" ], "modifiers": [ [ "species_10592847", "catalyst" ] ], "additional_components": [ "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54D06", "DDB_G0292596", "Q54FC5", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "P11467", "DDB_G0290961", "Q1ZXR0", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54D06", "DDB_G0292596" ] }, "reaction_10623337": { "compartment": "compartment_70101", "id": "reaction_10623337", "reactome": "R-DDI-8948018", "name": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10592919" ], "products": [ "species_10587623", "species_10623335" ], "modifiers": [], "additional_components": [ "Q54FC5", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "P11467", "DDB_G0290961", "Q1ZXR0", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54FC5", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "P11467", "DDB_G0290961", "Q1ZXR0", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54LU8", "DDB_G0286465" ] }, "reaction_10593870": { "compartment": "compartment_70101", "id": "reaction_10593870", "reactome": "R-DDI-507719", "name": "p62:MEKK3 binds to TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593866", "species_10584497" ], "products": [ "species_10593868" ], "modifiers": [], "additional_components": [ "Q55CE3", "DDB_G0270098", "Q54PX0", "DDB_G0284251", "Q55CA6", "DDB_G0284251", "Q8T2I8", "DDB_G0276465", "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q55CE3", "DDB_G0270098", "Q54PX0", "DDB_G0284251", "Q55CA6", "DDB_G0284251", "Q8T2I8", "DDB_G0276465" ] }, "reaction_10619777": { "compartment": "compartment_7660", "id": "reaction_10619777", "reactome": "R-DDI-8865605", "name": "BRWD1 binds SMARCA4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619773", "species_10602136" ], "products": [ "species_10619775" ], "modifiers": [], "additional_components": [ "DDB_G0285837", "DDB_G0271052", "Q55C32", "DDB_G0271052", "Q54MP8", "DDB_G0285837" ] }, "reaction_10619802": { "compartment": "compartment_7660", "id": "reaction_10619802", "reactome": "R-DDI-8865613", "name": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619773", "species_10619780" ], "products": [ "species_10619800" ], "modifiers": [], "additional_components": [ "DDB_G0285837", "DDB_G0291185", "Q54F38", "DDB_G0291185", "Q54MP8", "DDB_G0285837" ] }, "reaction_10623473": { "compartment": "compartment_70101", "id": "reaction_10623473", "reactome": "R-DDI-8950724", "name": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623469" ], "products": [ "species_10623471" ], "modifiers": [], "additional_components": [ "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381" ] }, "reaction_10623479": { "compartment": "compartment_70101", "id": "reaction_10623479", "reactome": "R-DDI-8950780", "name": "p-Y705-STAT3 binds p-Y693-STAT4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623421", "species_10596995" ], "products": [ "species_10623469" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638" ] }, "reaction_10623467": { "compartment": "compartment_70101", "id": "reaction_10623467", "reactome": "R-DDI-8950522", "name": "p-STAT1:p-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623463" ], "products": [ "species_10623465" ], "modifiers": [], "additional_components": [ "Q86I20", "DDB_G0275167", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "O00910", "DDB_G0281381", "Q86I20", "DDB_G0275167", "Q70GP4", "DDB_G0268638" ] }, "reaction_10623475": { "compartment": "compartment_70101", "id": "reaction_10623475", "reactome": "R-DDI-8950733", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597001" ], "products": [ "species_10597017" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381" ] }, "reaction_10623481": { "compartment": "compartment_70101", "id": "reaction_10623481", "reactome": "R-DDI-8950782", "name": "p-STAT1 binds p-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596995", "species_10594320" ], "products": [ "species_10597001" ], "modifiers": [], "additional_components": [ "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167" ] }, "reaction_10623477": { "compartment": "compartment_70101", "id": "reaction_10623477", "reactome": "R-DDI-8950778", "name": "p-Y693-STAT4 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623421" ], "products": [ "species_10623423" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "Q70GP4", "DDB_G0268638", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "Q70GP4", "DDB_G0268638" ] }, "reaction_10623437": { "compartment": "compartment_70101", "id": "reaction_10623437", "reactome": "R-DDI-8950181", "name": "Y693-STAT4 dimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623423" ], "products": [ "species_10623435" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "O00910", "DDB_G0281381", "Q86I20", "DDB_G0275167", "Q70GP4", "DDB_G0268638" ] }, "reaction_10624465": { "compartment": "compartment_70101", "id": "reaction_10624465", "reactome": "R-DDI-8987007", "name": "p-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623451" ], "products": [ "species_10624463" ], "modifiers": [], "additional_components": [ "Q54BD4", "DDB_G0293532", "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q54BD4", "DDB_G0293532", "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167" ] }, "reaction_10612568": { "compartment": "compartment_70101", "id": "reaction_10612568", "reactome": "R-DDI-6784763", "name": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596999" ], "products": [ "species_10597019" ], "modifiers": [], "additional_components": [ "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381" ] }, "reaction_10624491": { "compartment": "compartment_70101", "id": "reaction_10624491", "reactome": "R-DDI-8987052", "name": "p-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624477" ], "products": [ "species_10624489" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381" ] }, "reaction_10612570": { "compartment": "compartment_70101", "id": "reaction_10612570", "reactome": "R-DDI-6784765", "name": "p-Y705-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596995" ], "products": [ "species_10596999" ], "modifiers": [], "additional_components": [ "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638" ] }, "reaction_10624495": { "compartment": "compartment_70101", "id": "reaction_10624495", "reactome": "R-DDI-8987214", "name": "p-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624475" ], "products": [ "species_10624477" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167" ] }, "reaction_10624509": { "compartment": "compartment_70101", "id": "reaction_10624509", "reactome": "R-DDI-8987218", "name": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624463" ], "products": [ "species_10624507" ], "modifiers": [], "additional_components": [ "Q54BD4", "DDB_G0293532", "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q54BD4", "DDB_G0293532", "O00910", "DDB_G0281381", "Q86I20", "DDB_G0275167", "Q70GP4", "DDB_G0268638" ] }, "reaction_10603411": { "compartment": "compartment_876", "id": "reaction_10603411", "reactome": "R-DDI-3928619", "name": "PAK1 binds RAC1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590366", "species_10588143" ], "products": [ "species_10603409" ], "modifiers": [], "additional_components": [ "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "P34144", "DDB_G0277869", "species_29438", "P34144", "DDB_G0277869", "species_29438", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459" ] }, "reaction_10603426": { "compartment": "compartment_70101", "id": "reaction_10603426", "reactome": "R-DDI-3928620", "name": "PAK1 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10603409" ], "products": [ "species_10603423", "species_29370" ], "modifiers": [ [ "species_10603409", "catalyst" ] ], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459", "P34144", "DDB_G0277869", "species_29438", "P34144", "DDB_G0277869", "species_29438", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459" ] }, "reaction_10611057": { "compartment": "compartment_161320", "id": "reaction_10611057", "reactome": "R-DDI-5690517", "name": "PPT1 hydrolyses palmitoylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_5690533" ], "products": [ "species_6785219", "species_5690516" ], "modifiers": [ [ "species_10611054", "catalyst" ] ], "additional_components": [ "species_3632881", "species_6785219", "DDB_G0285533" ] }, "reaction_10624098": { "compartment": "compartment_5460", "id": "reaction_10624098", "reactome": "R-DDI-8957389", "name": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8957387" ], "products": [ "species_8957386", "species_113521" ], "modifiers": [ [ "species_10624095", "catalyst" ] ], "additional_components": [ "DDB_G0281965" ] }, "reaction_10593969": { "compartment": "compartment_70101", "id": "reaction_10593969", "reactome": "R-DDI-548800", "name": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_548819", "species_29508" ], "products": [ "species_113528", "species_548816", "species_76194" ], "modifiers": [ [ "species_10593966", "catalyst" ] ], "additional_components": [ "Q55BY4", "DDB_G0271066", "C7FZW5", "DDB_G0271066" ] }, "reaction_10593985": { "compartment": "compartment_70101", "id": "reaction_10593985", "reactome": "R-DDI-548818", "name": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_548812" ], "products": [ "species_548836", "species_29366" ], "modifiers": [ [ "species_10593982", "catalyst" ] ], "additional_components": [ "Q869Y3", "DDB_G0275049" ] }, "reaction_10593995": { "compartment": "compartment_70101", "id": "reaction_10593995", "reactome": "R-DDI-548831", "name": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_548809" ], "products": [ "species_428139", "species_29366" ], "modifiers": [ [ "species_10593990", "catalyst" ] ], "additional_components": [ "DDB_G0270270" ] }, "reaction_10593978": { "compartment": "compartment_70101", "id": "reaction_10593978", "reactome": "R-DDI-548814", "name": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29508", "species_200993" ], "products": [ "species_113528", "species_548812", "species_76194" ], "modifiers": [ [ "species_10593975", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10587452": { "compartment": "compartment_70101", "id": "reaction_10587452", "reactome": "R-DDI-201035", "name": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_3632881", "species_76194" ], "products": [ "species_111294", "species_29356", "species_200993", "species_76577" ], "modifiers": [ [ "species_10587449", "catalyst" ] ], "additional_components": [ "Q54JK0", "DDB_G0288001", "Q55DR6", "DDB_G0269242", "Q1ZXQ4", "DDB_G0269474" ] }, "reaction_10593980": { "compartment": "compartment_70101", "id": "reaction_10593980", "reactome": "R-DDI-548815", "name": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29508", "species_548794" ], "products": [ "species_113528", "species_548829", "species_76194" ], "modifiers": [ [ "species_10593975", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10607615": { "compartment": "compartment_12045", "id": "reaction_10607615", "reactome": "R-DDI-5676637", "name": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676631" ], "products": [ "species_29356", "species_5676634" ], "modifiers": [ [ "species_10607612", "catalyst" ] ], "additional_components": [ "Q54Y54", "DDB_G0278683", "Q54YR9", "DDB_G0278113" ] }, "reaction_10611854": { "compartment": "compartment_70101", "id": "reaction_10611854", "reactome": "R-DDI-5695957", "name": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_5695985", "species_76194" ], "products": [ "species_111294", "species_5695971", "species_76577" ], "modifiers": [ [ "species_10611851", "catalyst" ] ], "additional_components": [ "Q55CD5", "DDB_G0270106" ] }, "reaction_10611870": { "compartment": "compartment_5460", "id": "reaction_10611870", "reactome": "R-DDI-5696007", "name": "ACSF3 ligates CoA-SH to VLCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_5696008", "species_113593" ], "products": [ "species_159448", "species_159450", "species_5696003" ], "modifiers": [ [ "species_10611867", "catalyst" ] ], "additional_components": [ "DDB_G0289539" ] }, "reaction_10587362": { "compartment": "compartment_70101", "id": "reaction_10587362", "reactome": "R-DDI-200555", "name": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_113592", "species_76183" ], "products": [ "species_29372", "species_29370", "species_29508" ], "modifiers": [ [ "species_10581617", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "DDB_G0288387" ] }, "reaction_10581606": { "compartment": "compartment_70101", "id": "reaction_10581606", "reactome": "R-DDI-75848", "name": "ACLY tetramer transforms CIT to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76190", "species_113592", "species_76194" ], "products": [ "species_29372", "species_29370", "species_76183", "species_76213" ], "modifiers": [ [ "species_10581603", "catalyst" ] ], "additional_components": [ "Q54YA2", "DDB_G0278341" ] }, "reaction_10581675": { "compartment": "compartment_70101", "id": "reaction_10581675", "reactome": "R-DDI-75872", "name": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_76183", "species_29364", "species_29508" ], "products": [ "species_29356", "species_113528", "species_29366", "species_3632881", "species_76194" ], "modifiers": [ [ "species_10581672", "catalyst" ] ], "additional_components": [ "Q869X2", "DDB_G0275077", "Q55E72", "DDB_G0269364", "Q869W9", "DDB_G0275069" ] }, "reaction_10584076": { "compartment": "compartment_70101", "id": "reaction_10584076", "reactome": "R-DDI-163756", "name": "Formation of fatty acid synthase (FAS) dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581670" ], "products": [ "species_10581672" ], "modifiers": [], "additional_components": [ "Q869X2", "DDB_G0275077", "Q55E72", "DDB_G0269364", "Q869W9", "DDB_G0275069", "Q869X2", "DDB_G0275077", "Q55E72", "DDB_G0269364", "Q869W9", "DDB_G0275069" ] }, "reaction_10625008": { "compartment": "compartment_70101", "id": "reaction_10625008", "reactome": "R-DDI-9014641", "name": "HRSP12 deaminates 2AA to 2OBUTA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9014643" ], "products": [ "species_29382", "species_936714" ], "modifiers": [ [ "species_10625005", "catalyst" ] ], "additional_components": [ "DDB_G0277761" ] }, "reaction_10625000": { "compartment": "compartment_70101", "id": "reaction_10625000", "reactome": "R-DDI-9014627", "name": "SDS dimers:PXLP dehydrate L-Thr to 2AA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351990" ], "products": [ "species_29356", "species_9014643" ], "modifiers": [ [ "species_10624997", "catalyst" ] ], "additional_components": [ "Q86B06", "DDB_G0272787" ] }, "reaction_10585185": { "compartment": "compartment_876", "id": "reaction_10585185", "reactome": "R-DDI-170986", "name": "Ral-GDS binds to Ras-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585181", "species_10585144" ], "products": [ "species_10585183" ], "modifiers": [], "additional_components": [ "Q8IS18", "DDB_G0269252", "Q54WL2", "DDB_G0279569", "Q552M5", "DDB_G0276019", "Q8IS19", "DDB_G0289667", "Q8SSQ3", "DDB_G0274607", "Q54L90", "DDB_G0286773", "Q86G47", "DDB_G0289665", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q8IS18", "DDB_G0269252", "Q54WL2", "DDB_G0279569", "Q552M5", "DDB_G0276019", "Q8IS19", "DDB_G0289667", "Q8SSQ3", "DDB_G0274607", "Q54L90", "DDB_G0286773", "Q86G47", "DDB_G0289665" ] }, "reaction_10626117": { "compartment": "compartment_7660", "id": "reaction_10626117", "reactome": "R-DDI-9612509", "name": "SGK phosphorylates SRF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10626105" ], "products": [ "species_113582", "species_10626108" ], "modifiers": [ [ "species_10626114", "catalyst" ] ], "additional_components": [ "DDB_G0281387", "DDB_G0281387", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620" ] }, "reaction_10587062": { "compartment": "compartment_7660", "id": "reaction_10587062", "reactome": "R-DDI-198714", "name": "ERK5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587058" ], "products": [ "species_10587060" ], "modifiers": [], "additional_components": [ "DDB_G0286353", "DDB_G0286353" ] }, "reaction_10591923": { "compartment": "compartment_70101", "id": "reaction_10591923", "reactome": "R-DDI-430021", "name": "PAN2-PAN3 complex partially deadenylates mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10591908" ], "products": [ "species_10591904", "species_76577" ], "modifiers": [ [ "species_10591920", "catalyst" ] ], "additional_components": [ "Q75K16", "DDB_G0275459", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "Q54BM2", "DDB_G0293558", "Q55D61", "DDB_G0269192", "P90529", "DDB_G0269146", "Q75K16", "DDB_G0275459", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "Q54BM2", "DDB_G0293558", "Q55D61", "DDB_G0269192", "P90529", "DDB_G0269146", "Q55DD5", "DDB_G0269694", "P0CD65", "DDB_G0279129" ] }, "reaction_10623223": { "compartment": "compartment_70101", "id": "reaction_10623223", "reactome": "R-DDI-8941312", "name": "ZCCHC6, ZCCHC11 are mRNA uridyltransferases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6782337", "species_10591904" ], "products": [ "species_10623193" ], "modifiers": [ [ "species_10623220", "catalyst" ] ], "additional_components": [ "Q75K16", "DDB_G0275459", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "Q54BM2", "DDB_G0293558", "Q55D61", "DDB_G0269192", "P90529", "DDB_G0269146", "species_6782337", "Q75K16", "DDB_G0275459", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "Q54BM2", "DDB_G0293558", "Q55D61", "DDB_G0269192", "P90529", "DDB_G0269146", "Q8T2J7", "DDB_G0281431", "Q54Y43", "DDB_G0281431", "Q54TZ1", "DDB_G0281431" ] }, "reaction_10625515": { "compartment": "compartment_70101", "id": "reaction_10625515", "reactome": "R-DDI-9026005", "name": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9026293", "species_29368" ], "products": [ "species_9026311" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625519": { "compartment": "compartment_70101", "id": "reaction_10625519", "reactome": "R-DDI-9026007", "name": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9025012", "species_29366" ], "products": [ "species_9026307", "species_29364" ], "modifiers": [ [ "species_10600421", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10625517": { "compartment": "compartment_70101", "id": "reaction_10625517", "reactome": "R-DDI-9026006", "name": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9608444", "species_29368" ], "products": [ "species_9026293" ], "modifiers": [ [ "species_10600421", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10587587": { "compartment": "compartment_70101", "id": "reaction_10587587", "reactome": "R-DDI-202127", "name": "eNOS synthesizes NO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468", "species_29368", "species_29364" ], "products": [ "species_202124", "species_29366", "species_29968" ], "modifiers": [ [ "species_10587584", "catalyst" ], [ "species_5693375", "inhibitor" ] ], "additional_components": [ "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "P54651", "DDB_G0267400", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_29870" ] }, "reaction_10587763": { "compartment": "compartment_876", "id": "reaction_10587763", "reactome": "R-DDI-203613", "name": "depalmitoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587546" ], "products": [ "species_76168", "species_10587591" ], "modifiers": [ [ "species_10587760", "catalyst" ] ], "additional_components": [ "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_917877", "species_29426", "Q55CT1", "DDB_G0269912", "species_76629", "species_113596", "species_29870", "Q54T49", "DDB_G0282005" ] }, "reaction_10587749": { "compartment": "compartment_20699", "id": "reaction_10587749", "reactome": "R-DDI-203567", "name": "palmitoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587589", "species_200993" ], "products": [ "species_10587719" ], "modifiers": [ [ "species_10587746", "catalyst" ] ], "additional_components": [ "DDB_G0269912", "DDB_G0269912", "Q54VH7", "DDB_G0293930", "Q86A83", "DDB_G0293930", "Q552M6", "DDB_G0293930", "Q555N7", "DDB_G0293930", "Q54B34", "DDB_G0293930" ] }, "reaction_10598261": { "compartment": "compartment_70101", "id": "reaction_10598261", "reactome": "R-DDI-1497784", "name": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_10587580" ], "products": [ "species_10587584" ], "modifiers": [], "additional_components": [ "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "P54651", "DDB_G0267400", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_29870", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "P54651", "DDB_G0267400", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_29870" ] }, "reaction_10598276": { "compartment": "compartment_70101", "id": "reaction_10598276", "reactome": "R-DDI-1497869", "name": "Salvage - Sepiapterin is reduced to BH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_1497811", "species_29364" ], "products": [ "species_1497857", "species_29366" ], "modifiers": [ [ "species_10597898", "catalyst" ] ], "additional_components": [ "Q54GP3", "DDB_G0290009" ] }, "reaction_10587753": { "compartment": "compartment_70101", "id": "reaction_10587753", "reactome": "R-DDI-203611", "name": "N-myristoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_184174", "species_10587751" ], "products": [ "species_10587589" ], "modifiers": [], "additional_components": [ "DDB_G0269912", "DDB_G0269912" ] }, "reaction_10598265": { "compartment": "compartment_70101", "id": "reaction_10598265", "reactome": "R-DDI-1497796", "name": "BH2 binding can lead to eNOS uncoupling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1497857", "species_10587584" ], "products": [ "species_29870", "species_10598263" ], "modifiers": [], "additional_components": [ "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "P54651", "DDB_G0267400", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_29870", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "P54651", "DDB_G0267400", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_1497857", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_29870" ] }, "reaction_10587773": { "compartment": "compartment_20699", "id": "reaction_10587773", "reactome": "R-DDI-203700", "name": "eNOS translocation from Golgi to Caveolae", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587719" ], "products": [ "species_10587546" ], "modifiers": [], "additional_components": [ "DDB_G0269912", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596" ] }, "reaction_10587597": { "compartment": "compartment_20699", "id": "reaction_10587597", "reactome": "R-DDI-202132", "name": "depalmitoylated eNOS translocates from plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587591" ], "products": [ "species_10587595" ], "modifiers": [], "additional_components": [ "species_917877", "species_29426", "Q55CT1", "DDB_G0269912", "species_76629", "species_113596", "species_29870", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_29870" ] }, "reaction_10598268": { "compartment": "compartment_70101", "id": "reaction_10598268", "reactome": "R-DDI-1497810", "name": "Uncoupled eNOS favours the formation of superoxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29364" ], "products": [ "species_1222424", "species_29366" ], "modifiers": [ [ "species_10598263", "catalyst" ] ], "additional_components": [ "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "P54651", "DDB_G0267400", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_1497857", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_29870" ] }, "reaction_10587599": { "compartment": "compartment_70101", "id": "reaction_10587599", "reactome": "R-DDI-202137", "name": "AKT1 binds eNOS complex via HSP90", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587563", "species_10586949" ], "products": [ "species_10587571" ], "modifiers": [], "additional_components": [ "Q7Z2B8", "DDB_G0277917", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "species_74112", "P54651", "DDB_G0267400", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "Q7Z2B8", "DDB_G0277917", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "species_74112", "P54651", "DDB_G0267400", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596" ] }, "reaction_10587582": { "compartment": "compartment_70101", "id": "reaction_10587582", "reactome": "R-DDI-202111", "name": "AKT1 phosphorylates eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10587571" ], "products": [ "species_10587580", "species_29370" ], "modifiers": [], "additional_components": [ "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "Q7Z2B8", "DDB_G0277917", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "species_74112", "P54651", "DDB_G0267400", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "P54651", "DDB_G0267400", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_29870" ] }, "reaction_10592001": { "compartment": "compartment_70101", "id": "reaction_10592001", "reactome": "R-DDI-430028", "name": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429974" ], "products": [ "species_109402", "species_113578", "species_109395", "species_429926", "species_76577" ], "modifiers": [ [ "species_10591998", "catalyst" ] ], "additional_components": [ "Q54HV0", "DDB_G0289175", "Q54S59", "DDB_G0282793", "Q86K90", "DDB_G0277211", "Q55BJ2", "DDB_G0271100", "Q54VM4", "DDB_G0280251", "Q54CU6", "DDB_G0292692", "Q55BB0", "DDB_G0271396", "Q54EU6", "DDB_G0291328", "Q54Q83", "DDB_G0284053", "Q54EV5", "DDB_G0291310", "Q54N99", "DDB_G0285377", "Q54BH9", "DDB_G0293614", "Q7KWX9", "DDB_G0276783", "Q54QJ0", "DDB_G0283769" ] }, "reaction_10597571": { "compartment": "compartment_7660", "id": "reaction_10597571", "reactome": "R-DDI-1363311", "name": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597257", "species_10597559" ], "products": [ "species_10597569" ], "modifiers": [], "additional_components": [ "Q54FX2", "DDB_G0290551", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "P34112", "DDB_G0272813", "P34112", "DDB_G0272813", "Q54FX2", "DDB_G0290551", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129" ] }, "reaction_10597575": { "compartment": "compartment_7660", "id": "reaction_10597575", "reactome": "R-DDI-1363314", "name": "p107 (RBL1) binds CyclinE/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597559", "species_10597255" ], "products": [ "species_10597573" ], "modifiers": [], "additional_components": [ "P34112", "DDB_G0272813", "DDB_G0290551", "Q54FX2", "DDB_G0290551", "P34112", "DDB_G0272813" ] }, "reaction_10597563": { "compartment": "compartment_7660", "id": "reaction_10597563", "reactome": "R-DDI-1363303", "name": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597246", "species_10597559" ], "products": [ "species_10597561" ], "modifiers": [], "additional_components": [ "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551", "Q7KWP1", "DDB_G0276799", "P34112", "DDB_G0272813", "P34112", "DDB_G0272813", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551", "Q7KWP1", "DDB_G0276799" ] }, "reaction_10597274": { "compartment": "compartment_7660", "id": "reaction_10597274", "reactome": "R-DDI-1227670", "name": "Recruitment of HDAC1 by p130 (RBL2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597246", "species_10597270" ], "products": [ "species_10597272" ], "modifiers": [], "additional_components": [ "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551", "Q7KWP1", "DDB_G0276799", "DDB_G0268024", "Q55FN5", "DDB_G0268024", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551", "Q7KWP1", "DDB_G0276799" ] }, "reaction_10597567": { "compartment": "compartment_7660", "id": "reaction_10597567", "reactome": "R-DDI-1363306", "name": "p130 (RBL2) binds Cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597229", "species_10597559" ], "products": [ "species_10597565" ], "modifiers": [], "additional_components": [ "DDB_G0290551", "P34112", "DDB_G0272813", "P34112", "DDB_G0272813", "Q54FX2", "DDB_G0290551" ] }, "reaction_10597278": { "compartment": "compartment_7660", "id": "reaction_10597278", "reactome": "R-DDI-1227671", "name": "Recruitment of HDAC1 by p107 (RBL1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597257", "species_10597270" ], "products": [ "species_10597276" ], "modifiers": [], "additional_components": [ "Q54FX2", "DDB_G0290551", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "DDB_G0268024", "Q55FN5", "DDB_G0268024", "Q54FX2", "DDB_G0290551", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129" ] }, "reaction_10586837": { "compartment": "compartment_70101", "id": "reaction_10586837", "reactome": "R-DDI-196929", "name": "FLAD1 phosphorylates FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_73524" ], "products": [ "species_111294", "species_29386" ], "modifiers": [ [ "species_10586834", "catalyst" ] ], "additional_components": [ "DDB_G0282955" ] }, "reaction_10586847": { "compartment": "compartment_70101", "id": "reaction_10586847", "reactome": "R-DDI-196955", "name": "2xENPP1 hydrolyzes FAD to FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29386" ], "products": [ "species_73524", "species_76577" ], "modifiers": [ [ "species_10586844", "catalyst" ] ], "additional_components": [ "Q54MJ8", "DDB_G0285897" ] }, "reaction_10604772": { "compartment": "compartment_13231", "id": "reaction_10604772", "reactome": "R-DDI-5221130", "name": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_5221122" ], "products": [ "species_113550", "species_5221124" ], "modifiers": [ [ "species_10603651", "catalyst" ] ], "additional_components": [ "Q75JA1", "DDB_G0271730" ] }, "reaction_10602755": { "compartment": "compartment_70101", "id": "reaction_10602755", "reactome": "R-DDI-3371422", "name": "ATP hydrolysis by HSP70", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602750" ], "products": [ "species_29372", "species_10602752" ], "modifiers": [ [ "species_10602750", "catalyst" ], [ "species_10602748", "catalyst" ] ], "additional_components": [ "species_113592", "P36415", "DDB_G0269144", "Q54VQ1", "DDB_G0280037", "Q54ED3", "DDB_G0291568", "species_29370", "P36415", "DDB_G0269144", "Q54VQ1", "DDB_G0280037", "Q54ED3", "DDB_G0291568", "species_113592", "P36415", "DDB_G0269144", "Q54VQ1", "DDB_G0280037", "Q54ED3", "DDB_G0291568", "Q54VQ1", "DDB_G0280037", "Q54ED3", "DDB_G0291568" ] }, "reaction_10605698": { "compartment": "compartment_70101", "id": "reaction_10605698", "reactome": "R-DDI-5618098", "name": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589012", "species_10605696" ], "products": [ "species_10602796", "species_10602861", "species_10605561" ], "modifiers": [], "additional_components": [ "DDB_G0268042", "Q54QI6", "DDB_G0283815", "species_29370", "P36415", "DDB_G0269144", "P54651", "DDB_G0267400", "species_113592", "Q54DA8", "DDB_G0292404", "DDB_G0292404", "species_113592", "P36415", "DDB_G0269144", "Q54QI6", "DDB_G0283815", "Q55FM3", "DDB_G0268042", "P54651", "DDB_G0267400", "species_113592" ] }, "reaction_10605704": { "compartment": "compartment_70101", "id": "reaction_10605704", "reactome": "R-DDI-5618099", "name": "SH binds SHR within the HSP90 chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5618094", "species_10605702" ], "products": [ "species_10605571" ], "modifiers": [], "additional_components": [ "species_193057", "species_469662", "CHEBI:16973", "CHEBI:17650", "CHEBI:27584", "species_193055", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "species_113592", "Q54QI6", "DDB_G0283815", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "species_113592", "Q54QI6", "DDB_G0283815" ] }, "reaction_10605706": { "compartment": "compartment_70101", "id": "reaction_10605706", "reactome": "R-DDI-5618105", "name": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605688", "species_10605557" ], "products": [ "species_10605696" ], "modifiers": [], "additional_components": [ "species_29370", "P36415", "DDB_G0269144", "P54651", "DDB_G0267400", "species_113592", "Q54DA8", "DDB_G0292404", "DDB_G0283815", "Q54QI6", "DDB_G0283815", "species_29370", "P36415", "DDB_G0269144", "P54651", "DDB_G0267400", "species_113592", "Q54DA8", "DDB_G0292404" ] }, "reaction_10627342": { "compartment": "compartment_70101", "id": "reaction_10627342", "reactome": "R-DDI-9678925", "name": "NR3C1 binds NR3C1 agonists", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9678859", "species_10605575" ], "products": [ "species_10627340" ], "modifiers": [], "additional_components": [ "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "species_113592", "Q54QI6", "DDB_G0283815", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "species_113592", "Q54QI6", "DDB_G0283815" ] }, "reaction_10605708": { "compartment": "compartment_70101", "id": "reaction_10605708", "reactome": "R-DDI-5618107", "name": "ATP binding to HSP90 triggers conformation change", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10602808" ], "products": [ "species_10605688" ], "modifiers": [], "additional_components": [ "P54651", "DDB_G0267400", "species_29370", "P36415", "DDB_G0269144", "Q54DA8", "DDB_G0292404", "species_29370", "P36415", "DDB_G0269144", "P54651", "DDB_G0267400", "species_113592", "Q54DA8", "DDB_G0292404" ] }, "reaction_10602863": { "compartment": "compartment_70101", "id": "reaction_10602863", "reactome": "R-DDI-3371590", "name": "HSP70 binds to HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602861", "species_10602859" ], "products": [ "species_10602750" ], "modifiers": [], "additional_components": [ "species_113592", "P36415", "DDB_G0269144", "Q54VQ1", "DDB_G0280037", "Q54ED3", "DDB_G0291568", "species_113592", "P36415", "DDB_G0269144", "Q54VQ1", "DDB_G0280037", "Q54ED3", "DDB_G0291568" ] }, "reaction_10605710": { "compartment": "compartment_70101", "id": "reaction_10605710", "reactome": "R-DDI-5618110", "name": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605690", "species_10589012" ], "products": [ "species_10602796", "species_10605565", "species_10602861" ], "modifiers": [], "additional_components": [ "species_29370", "P36415", "DDB_G0269144", "P54651", "DDB_G0267400", "species_113592", "Q54DA8", "DDB_G0292404", "Q54QI6", "DDB_G0283815", "DDB_G0268042", "DDB_G0292404", "Q55FM3", "DDB_G0268042", "P54651", "DDB_G0267400", "species_113592", "Q54QI6", "DDB_G0283815", "species_113592", "P36415", "DDB_G0269144" ] }, "reaction_10627379": { "compartment": "compartment_70101", "id": "reaction_10627379", "reactome": "R-DDI-9690534", "name": "SH binds NR3C1 (in HSP90:ATP:FKBP4:PTGES3:NR3C1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5618094", "species_10605575" ], "products": [ "species_10605577" ], "modifiers": [ [ "species_10627340", "catalyst" ] ], "additional_components": [ "species_193057", "species_469662", "CHEBI:16973", "CHEBI:17650", "CHEBI:27584", "species_193055", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "species_113592", "Q54QI6", "DDB_G0283815", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "species_113592", "Q54QI6", "DDB_G0283815", "species_193057", "species_469662", "CHEBI:16973", "CHEBI:17650", "CHEBI:27584", "species_193055", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "species_113592", "Q54QI6", "DDB_G0283815" ] }, "reaction_10605685": { "compartment": "compartment_70101", "id": "reaction_10605685", "reactome": "R-DDI-5618080", "name": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605577", "species_10605571" ], "products": [ "species_10605581", "species_10605587" ], "modifiers": [ [ "species_10605683", "catalyst" ] ], "additional_components": [ "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "species_113592", "Q54QI6", "DDB_G0283815", "species_193057", "species_469662", "CHEBI:16973", "CHEBI:17650", "CHEBI:27584", "species_193055", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "species_113592", "Q54QI6", "DDB_G0283815", "Q54QI6", "DDB_G0283815", "P54651", "DDB_G0267400", "species_113592", "Q55FM3", "DDB_G0268042", "Q54QI6", "DDB_G0283815", "P54651", "DDB_G0267400", "species_113592", "Q55FM3", "DDB_G0268042", "species_469662", "CHEBI:17650", "species_193055", "CHEBI:27584", "CHEBI:16973", "species_193057", "P54703", "DDB_G0280849", "Q86A88", "DDB_G0274815", "Q54CI8", "DDB_G0292904", "P34036", "DDB_G0276355", "Q54VD6", "DDB_G0280435", "Q54ZI7", "DDB_G0277561", "Q54N50", "DDB_G0285503", "P13021", "DDB_G0267374", "P13022", "DDB_G0272104", "Q54JY2", "DDB_G0287739", "Q54FM4", "DDB_G0290757", "Q54VS0", "DDB_G0280175", "Q54XU5", "DDB_G0278579", "Q54I79", "DDB_G0288937", "species_29438", "species_29420" ] }, "reaction_10627419": { "compartment": "compartment_70101", "id": "reaction_10627419", "reactome": "R-DDI-9705925", "name": "Androgens binds AR (in the HSP90 chaperone complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8979218", "species_10627413" ], "products": [ "species_10627417" ], "modifiers": [], "additional_components": [ "species_193057", "species_193079", "species_469662", "CHEBI:29117", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "species_113592", "Q54QI6", "DDB_G0283815", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "species_193057", "species_193079", "species_469662", "CHEBI:29117", "species_113592", "Q54QI6", "DDB_G0283815" ] }, "reaction_10602810": { "compartment": "compartment_70101", "id": "reaction_10602810", "reactome": "R-DDI-3371503", "name": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602796", "species_10602802", "species_10602752" ], "products": [ "species_10602748", "species_10602808" ], "modifiers": [], "additional_components": [ "DDB_G0292404", "P54651", "DDB_G0267400", "species_29370", "P36415", "DDB_G0269144", "Q54VQ1", "DDB_G0280037", "Q54ED3", "DDB_G0291568", "Q54VQ1", "DDB_G0280037", "Q54ED3", "DDB_G0291568", "P54651", "DDB_G0267400", "species_29370", "P36415", "DDB_G0269144", "Q54DA8", "DDB_G0292404" ] }, "reaction_10605692": { "compartment": "compartment_70101", "id": "reaction_10605692", "reactome": "R-DDI-5618085", "name": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605563", "species_10605688" ], "products": [ "species_10605690" ], "modifiers": [], "additional_components": [ "DDB_G0283815", "species_29370", "P36415", "DDB_G0269144", "P54651", "DDB_G0267400", "species_113592", "Q54DA8", "DDB_G0292404", "species_29370", "P36415", "DDB_G0269144", "P54651", "DDB_G0267400", "species_113592", "Q54DA8", "DDB_G0292404", "Q54QI6", "DDB_G0283815" ] }, "reaction_10605567": { "compartment": "compartment_70101", "id": "reaction_10605567", "reactome": "R-DDI-5618073", "name": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605563", "species_10605561" ], "products": [ "species_10605565", "species_10605557" ], "modifiers": [ [ "species_5618094", "catalyst" ] ], "additional_components": [ "DDB_G0283815", "Q54QI6", "DDB_G0283815", "Q55FM3", "DDB_G0268042", "P54651", "DDB_G0267400", "species_113592", "Q55FM3", "DDB_G0268042", "P54651", "DDB_G0267400", "species_113592", "Q54QI6", "DDB_G0283815", "DDB_G0283815", "species_193057", "species_469662", "CHEBI:16973", "CHEBI:17650", "CHEBI:27584", "species_193055" ] }, "reaction_10584784": { "compartment": "compartment_5460", "id": "reaction_10584784", "reactome": "R-DDI-169270", "name": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73663", "species_10584773" ], "products": [ "species_76633", "species_10584771" ], "modifiers": [ [ "species_10584781", "catalyst" ] ], "additional_components": [ "Q54YZ4", "DDB_G0277991", "species_31649", "species_76577", "Q54FD7", "DDB_G0290927", "Q54YZ4", "DDB_G0277991", "species_76577", "Q54FD7", "DDB_G0290927", "species_113596", "DDB_G0278849" ] }, "reaction_10612771": { "compartment": "compartment_5460", "id": "reaction_10612771", "reactome": "R-DDI-6788523", "name": "NUBPL transfers 4Fe-4S to Complex I subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612759", "species_10610755" ], "products": [ "species_10610753", "species_10612769" ], "modifiers": [], "additional_components": [ "Q54NI6", "DDB_G0285239", "Q86K57", "DDB_G0277231", "Q34312", "DDB_G0294052", "Q23883", "DDB_G0294030", "Q54F15", "DDB_G0291193", "DDB_G0291193", "Q34312", "DDB_G0294052", "Q23883", "DDB_G0294030", "Q54NI6", "DDB_G0285239", "Q86K57", "DDB_G0277231" ] }, "reaction_10612787": { "compartment": "compartment_5460", "id": "reaction_10612787", "reactome": "R-DDI-6788556", "name": "NUBPL transfers 4Fe-4S to NDUFV1, V2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612781", "species_10612776", "species_76629", "species_10610755" ], "products": [ "species_10612783", "species_10610753", "species_10612785" ], "modifiers": [], "additional_components": [ "DDB_G0291173", "DDB_G0288875", "Q54F15", "DDB_G0291193", "species_76629", "Q54I90", "DDB_G0288875", "DDB_G0291193", "Q54F10", "DDB_G0291173" ] }, "reaction_10610757": { "compartment": "compartment_5460", "id": "reaction_10610757", "reactome": "R-DDI-5690023", "name": "NUBPL binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_169274", "species_10610753" ], "products": [ "species_10610755" ], "modifiers": [], "additional_components": [ "DDB_G0291193", "Q54F15", "DDB_G0291193" ] }, "reaction_10616447": { "compartment": "compartment_5460", "id": "reaction_10616447", "reactome": "R-DDI-6800868", "name": "NDUF subunits bind to form the IP subcomplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612767", "species_10615711", "species_10612765", "species_10615723", "species_10615718" ], "products": [ "species_10615725" ], "modifiers": [], "additional_components": [ "Q86K57", "DDB_G0277231", "Q23883", "DDB_G0294030", "Q54S83", "DDB_G0282615", "Q54NI6", "DDB_G0285239", "DDB_G0294032", "Q559Z0", "DDB_G0272266", "species_113596", "Q559Z0", "DDB_G0272266", "species_113596", "P22237", "DDB_G0294032", "Q54NI6", "DDB_G0285239", "Q23883", "DDB_G0294030", "Q54S83", "DDB_G0282615", "Q86K57", "DDB_G0277231" ] }, "reaction_10584776": { "compartment": "compartment_5460", "id": "reaction_10584776", "reactome": "R-DDI-169260", "name": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584771", "species_31649" ], "products": [ "species_113596", "species_10584773" ], "modifiers": [ [ "species_10584771", "catalyst" ] ], "additional_components": [ "Q54YZ4", "DDB_G0277991", "species_76577", "Q54FD7", "DDB_G0290927", "species_113596", "Q54YZ4", "DDB_G0277991", "species_31649", "species_76577", "Q54FD7", "DDB_G0290927", "Q54YZ4", "DDB_G0277991", "species_76577", "Q54FD7", "DDB_G0290927", "species_113596" ] }, "reaction_10584136": { "compartment": "compartment_70616", "id": "reaction_10584136", "reactome": "R-DDI-164651", "name": "Electron transfer from ubiquinol to cytochrome c of complex III", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73663", "species_113529", "species_76633", "species_10584033" ], "products": [ "species_10584031", "species_73663", "species_76633", "species_163953" ], "modifiers": [ [ "species_10584133", "catalyst" ] ], "additional_components": [ "CHEBI:38574", "Q869N1", "DDB_G0275537", "CHEBI:38573", "Q869N1", "DDB_G0275537", "Q1ZXP3", "DDB_G0271774", "Q37311", "DDB_G0294078", "Q54NW9", "DDB_G0284947", "Q54V76", "DDB_G0280569", "Q4W6B5", "DDB_G0288777", "Q54M82", "DDB_G0286171", "Q54D07", "DDB_G0292594", "Q54QR8", "DDB_G0283669", "Q86A84", "DDB_G0274809" ] }, "reaction_10616628": { "compartment": "compartment_7660", "id": "reaction_10616628", "reactome": "R-DDI-6805640", "name": "AKT phosphorylates KAT6A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10616601" ], "products": [ "species_113582", "species_10616626" ], "modifiers": [ [ "species_10587267", "catalyst" ] ], "additional_components": [ "Q54QM3", "DDB_G0283859", "B0G130", "DDB_G0279699", "Q869X5", "DDB_G0279699", "Q54NG3", "DDB_G0285275", "Q54PN9", "DDB_G0284411", "Q54QM3", "DDB_G0283859", "B0G130", "DDB_G0279699", "Q869X5", "DDB_G0279699", "Q54NG3", "DDB_G0285275", "Q54PN9", "DDB_G0284411", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795" ] }, "reaction_10622674": { "compartment": "compartment_7660", "id": "reaction_10622674", "reactome": "R-DDI-8877692", "name": "PIN1 binds phosphorylated PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622667", "species_10594992" ], "products": [ "species_10622672" ], "modifiers": [], "additional_components": [ "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635", "Q86D86", "DDB_G0283615", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "DDB_G0268618", "Q55EZ0", "DDB_G0268618", "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635", "Q86D86", "DDB_G0283615", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190" ] }, "reaction_10617814": { "compartment": "compartment_7660", "id": "reaction_10617814", "reactome": "R-DDI-6811522", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6810408", "species_29358" ], "products": [ "species_113582", "species_6810412" ], "modifiers": [ [ "species_10617811", "catalyst" ] ], "additional_components": [ "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635", "Q86D86", "DDB_G0283615", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190" ] }, "reaction_10617479": { "compartment": "compartment_7660", "id": "reaction_10617479", "reactome": "R-DDI-6810376", "name": "ING2 binds PI5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6810408", "species_10603513" ], "products": [ "species_10617477" ], "modifiers": [], "additional_components": [ "DDB_G0284411", "Q54PN9", "DDB_G0284411", "species_6810408" ] }, "reaction_10622670": { "compartment": "compartment_7660", "id": "reaction_10622670", "reactome": "R-DDI-8877691", "name": "MAP2K6 phosphorylates PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10622656" ], "products": [ "species_113582", "species_10622667" ], "modifiers": [ [ "species_10593040", "catalyst" ] ], "additional_components": [ "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635", "Q86D86", "DDB_G0283615", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635", "Q86D86", "DDB_G0283615", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "DDB_G0289277" ] }, "reaction_10616616": { "compartment": "compartment_7660", "id": "reaction_10616616", "reactome": "R-DDI-6805638", "name": "KAT6A acetylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616607", "species_113560" ], "products": [ "species_2485002", "species_10616613" ], "modifiers": [ [ "species_10616607", "catalyst" ] ], "additional_components": [ "Q54QM3", "DDB_G0283859", "B0G130", "DDB_G0279699", "Q869X5", "DDB_G0279699", "Q54NG3", "DDB_G0285275", "Q54PN9", "DDB_G0284411", "Q54MF7", "DDB_G0285989", "Q54QM3", "DDB_G0283859", "B0G130", "DDB_G0279699", "Q869X5", "DDB_G0279699", "Q54NG3", "DDB_G0285275", "Q54PN9", "DDB_G0284411", "Q54MF7", "DDB_G0285989", "Q54QM3", "DDB_G0283859", "B0G130", "DDB_G0279699", "Q869X5", "DDB_G0279699", "Q54NG3", "DDB_G0285275", "Q54PN9", "DDB_G0284411", "Q54MF7", "DDB_G0285989" ] }, "reaction_10577937": { "compartment": "compartment_5460", "id": "reaction_10577937", "reactome": "R-DDI-70670", "name": "PRODH oxidises L-Pro to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113597", "species_379717" ], "products": [ "species_113529", "species_113590", "species_164934" ], "modifiers": [ [ "species_10577934", "catalyst" ] ], "additional_components": [ "DDB_G0275669" ] }, "reaction_10623999": { "compartment": "compartment_5460", "id": "reaction_10623999", "reactome": "R-DDI-8955817", "name": "PRODH2 oxidises HPRO to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113597", "species_6784215" ], "products": [ "species_113590", "species_164934", "species_113521" ], "modifiers": [ [ "species_10612516", "catalyst" ] ], "additional_components": [ "DDB_G0275669" ] }, "reaction_10597318": { "compartment": "compartment_70101", "id": "reaction_10597318", "reactome": "R-DDI-1247645", "name": "RHAG transports CO2 from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113528" ], "products": [ "species_1237009" ], "modifiers": [ [ "species_10592544", "catalyst" ] ], "additional_components": [ "Q8I0L6", "DDB_G0280059", "Q9NIV0", "DDB_G0283389" ] }, "reaction_10597320": { "compartment": "compartment_70101", "id": "reaction_10597320", "reactome": "R-DDI-1247649", "name": "AQP1 tetramer transports CO2 from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113528" ], "products": [ "species_1237009" ], "modifiers": [ [ "species_10592019", "catalyst" ] ], "additional_components": [ "Q9U8P7", "DDB_G0267378" ] }, "reaction_10608673": { "compartment": "compartment_7660", "id": "reaction_10608673", "reactome": "R-DDI-5687664", "name": "FEN1 cleaves displaced ssDNA flaps during MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10608663" ], "products": [ "species_10608670", "species_10577480", "species_68454" ], "modifiers": [ [ "species_10608663", "catalyst" ] ], "additional_components": [ "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54NU0", "DDB_G0284987", "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "DDB_G0284987", "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54NU0", "DDB_G0284987" ] }, "reaction_10608661": { "compartment": "compartment_7660", "id": "reaction_10608661", "reactome": "R-DDI-5687640", "name": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10608650" ], "products": [ "species_113541", "species_10608658" ], "modifiers": [ [ "species_10608650", "catalyst" ] ], "additional_components": [ "Q54S42", "DDB_G0282679", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54NU0", "DDB_G0284987", "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54S42", "DDB_G0282679", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q54NU0", "DDB_G0284987", "Q54S42", "DDB_G0282679", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54NU0", "DDB_G0284987" ] }, "reaction_10608677": { "compartment": "compartment_7660", "id": "reaction_10608677", "reactome": "R-DDI-5687673", "name": "MRN recruits LIG3:XRCC1 to MMEJ sites", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608670", "species_10580807" ], "products": [ "species_10608675" ], "modifiers": [], "additional_components": [ "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786" ] }, "reaction_10608666": { "compartment": "compartment_7660", "id": "reaction_10608666", "reactome": "R-DDI-5687653", "name": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427523", "species_10608658" ], "products": [ "species_427497", "species_10606279", "species_10608663", "species_10608644" ], "modifiers": [ [ "species_10608658", "catalyst" ] ], "additional_components": [ "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54S42", "DDB_G0282679", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q54NU0", "DDB_G0284987", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820", "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54NU0", "DDB_G0284987", "Q54S42", "DDB_G0282679", "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54S42", "DDB_G0282679", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q54NU0", "DDB_G0284987" ] }, "reaction_10608637": { "compartment": "compartment_7660", "id": "reaction_10608637", "reactome": "R-DDI-5687464", "name": "MRN and RBBP8 resect DNA DSBs in MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10608630" ], "products": [ "species_30555", "species_10608634" ], "modifiers": [ [ "species_10608630", "catalyst" ] ], "additional_components": [ "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786" ] }, "reaction_10608652": { "compartment": "compartment_7660", "id": "reaction_10608652", "reactome": "R-DDI-5687484", "name": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608634", "species_10577480", "species_10606233", "species_10608644" ], "products": [ "species_10608650" ], "modifiers": [], "additional_components": [ "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "DDB_G0284987", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q54S42", "DDB_G0282679", "Q54S42", "DDB_G0282679", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54NU0", "DDB_G0284987" ] }, "reaction_10608369": { "compartment": "compartment_7660", "id": "reaction_10608369", "reactome": "R-DDI-5685230", "name": "CHEK1 phosphorylates RAD51", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10608364" ], "products": [ "species_113582", "species_10608367" ], "modifiers": [ [ "species_10577605", "catalyst" ] ], "additional_components": [ "DDB_G0273139", "DDB_G0273139", "DDB_G0279719" ] }, "reaction_10608453": { "compartment": "compartment_7660", "id": "reaction_10608453", "reactome": "R-DDI-5685341", "name": "BCDX2 complex stabilizes RAD51 filament", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608435", "species_10608449" ], "products": [ "species_10608451" ], "modifiers": [], "additional_components": [ "Q54BU8", "DDB_G0293414", "Q557E6", "DDB_G0273139", "Q86IV6", "DDB_G0274777", "Q54Q57", "DDB_G0284153", "Q54DM3", "DDB_G0292130", "Q54GC4", "DDB_G0290275", "Q8T2T7", "DDB_G0275257", "Q54ED2", "DDB_G0291570", "Q54EK9", "DDB_G0291466", "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54LI7", "DDB_G0286621", "Q1ZXF0", "DDB_G0285287", "Q54PJ7", "DDB_G0284507", "Q54G98", "DDB_G0290297", "Q1ZXF0", "DDB_G0285287", "Q54PJ7", "DDB_G0284507", "Q54G98", "DDB_G0290297", "Q54BU8", "DDB_G0293414", "Q557E6", "DDB_G0273139", "Q86IV6", "DDB_G0274777", "Q54Q57", "DDB_G0284153", "Q54DM3", "DDB_G0292130", "Q54GC4", "DDB_G0290275", "Q8T2T7", "DDB_G0275257", "Q54ED2", "DDB_G0291570", "Q54EK9", "DDB_G0291466", "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54LI7", "DDB_G0286621" ] }, "reaction_10608379": { "compartment": "compartment_7660", "id": "reaction_10608379", "reactome": "R-DDI-5685242", "name": "CHEK1 phosphorylates BRCA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10608374" ], "products": [ "species_113582", "species_10608377" ], "modifiers": [ [ "species_10577605", "catalyst" ] ], "additional_components": [ "DDB_G0293414", "DDB_G0293414", "DDB_G0279719" ] }, "reaction_10608473": { "compartment": "compartment_7660", "id": "reaction_10608473", "reactome": "R-DDI-5685994", "name": "Long-range resection of DNA DSBs by EXO1 or DNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10608468" ], "products": [ "species_30555", "species_10608470" ], "modifiers": [ [ "species_10608468", "catalyst" ] ], "additional_components": [ "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54EK9", "DDB_G0291466", "Q86IV6", "DDB_G0274777", "Q54Q57", "DDB_G0284153", "Q54DM3", "DDB_G0292130", "Q54GC4", "DDB_G0290275", "Q8T2T7", "DDB_G0275257", "Q54ED2", "DDB_G0291570", "Q54LI7", "DDB_G0286621", "Q86IV6", "DDB_G0274777", "Q54Q57", "DDB_G0284153", "Q54DM3", "DDB_G0292130", "Q54GC4", "DDB_G0290275", "Q8T2T7", "DDB_G0275257", "Q54ED2", "DDB_G0291570", "Q54EK9", "DDB_G0291466", "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54LI7", "DDB_G0286621", "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54EK9", "DDB_G0291466", "Q86IV6", "DDB_G0274777", "Q54Q57", "DDB_G0284153", "Q54DM3", "DDB_G0292130", "Q54GC4", "DDB_G0290275", "Q8T2T7", "DDB_G0275257", "Q54ED2", "DDB_G0291570", "Q54LI7", "DDB_G0286621" ] }, "reaction_10581776": { "compartment": "compartment_7660", "id": "reaction_10581776", "reactome": "R-DDI-75998", "name": "Formation of RAD52 heptameric ring structure complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581772" ], "products": [ "species_10581774" ], "modifiers": [], "additional_components": [ "DDB_G0269406", "Q55E38", "DDB_G0269406" ] }, "reaction_10612584": { "compartment": "compartment_7660", "id": "reaction_10612584", "reactome": "R-DDI-6785594", "name": "FANCD2 binds FANCI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612575", "species_10612580" ], "products": [ "species_10612582" ], "modifiers": [], "additional_components": [ "DDB_G0268216", "DDB_G0293476", "Q54BR4", "DDB_G0293476", "Q55F81", "DDB_G0268216" ] }, "reaction_10582999": { "compartment": "compartment_70101", "id": "reaction_10582999", "reactome": "R-DDI-111925", "name": "cAMP induces dissociation of inactive PKA tetramers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582995" ], "products": [ "species_10582991", "species_10582997" ], "modifiers": [], "additional_components": [ "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029", "P05987", "DDB_G0279413", "Q8MM62", "DDB_G0276027", "species_30389", "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029", "species_30389", "P05987", "DDB_G0279413", "Q8MM62", "DDB_G0276027" ] }, "reaction_10611073": { "compartment": "compartment_70101", "id": "reaction_10611073", "reactome": "R-DDI-5690808", "name": "UCHL3, SENP8 cleave NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10611064" ], "products": [ "species_10611070", "species_10611068" ], "modifiers": [ [ "species_10611064", "catalyst" ] ], "additional_components": [ "Q54T48", "DDB_G0282007", "Q54XV3", "DDB_G0278711", "DDB_G0278711", "Q54T48", "DDB_G0282007", "Q54XV3", "DDB_G0278711", "Q54T48", "DDB_G0282007", "Q54XV3", "DDB_G0278711" ] }, "reaction_10623717": { "compartment": "compartment_70101", "id": "reaction_10623717", "reactome": "R-DDI-8952618", "name": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623697" ], "products": [ "species_10623709", "species_10623518" ], "modifiers": [ [ "species_10623697", "catalyst" ], [ "species_10623715", "inhibitor" ] ], "additional_components": [ "Q54XV3", "DDB_G0278711", "Q54TI6", "DDB_G0281725", "Q54GP1", "DDB_G0290025", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q54GP1", "DDB_G0290025", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54XV3", "DDB_G0278711", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "DDB_G0281725", "Q54XV3", "DDB_G0278711", "Q54TI6", "DDB_G0281725", "Q54GP1", "DDB_G0290025", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q54GP1", "DDB_G0290025", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813" ] }, "reaction_10624069": { "compartment": "compartment_7660", "id": "reaction_10624069", "reactome": "R-DDI-8956045", "name": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623818" ], "products": [ "species_10624064", "species_10624066" ], "modifiers": [ [ "species_10611193", "catalyst" ] ], "additional_components": [ "Q54MP2", "DDB_G0285813", "Q54DR0", "DDB_G0292074", "Q54XV3", "DDB_G0278711", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54E28", "DDB_G0291832", "Q551N8", "DDB_G0276481", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54IY4", "DDB_G0288453", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q55DE3", "DDB_G0269686", "Q54MH6", "DDB_G0285847", "Q552R1", "DDB_G0275925", "Q54K33", "DDB_G0287629", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54DR0", "DDB_G0292074", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54E28", "DDB_G0291832", "Q551N8", "DDB_G0276481", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54IY4", "DDB_G0288453", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q55DE3", "DDB_G0269686", "Q54MH6", "DDB_G0285847", "Q552R1", "DDB_G0275925", "Q54K33", "DDB_G0287629", "Q54PF3", "DDB_G0284597", "Q54QX3", "DDB_G0283587", "Q54HL6", "DDB_G0289361", "Q55BD5", "DDB_G0271282", "Q54E53", "DDB_G0291848", "Q54C92", "DDB_G0293180", "Q75K24", "DDB_G0275471", "Q54B82", "DDB_G0293844" ] }, "reaction_10623720": { "compartment": "compartment_70101", "id": "reaction_10623720", "reactome": "R-DDI-8952620", "name": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623695", "species_10623652", "species_10623542" ], "products": [ "species_10623697" ], "modifiers": [], "additional_components": [ "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54TI6", "DDB_G0281725", "Q54XV3", "DDB_G0278711", "Q54TI6", "DDB_G0281725", "Q54GP1", "DDB_G0290025", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813" ] }, "reaction_10623656": { "compartment": "compartment_70101", "id": "reaction_10623656", "reactome": "R-DDI-8952039", "name": "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623629", "species_10623576", "species_10623652" ], "products": [ "species_10623654" ], "modifiers": [], "additional_components": [ "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q9XZJ3", "DDB_G0267384", "O60999", "DDB_G0291972", "Q54XF7", "DDB_G0278991", "Q54J43", "DDB_G0288307", "Q54X83", "DDB_G0279139", "Q54Q05", "DDB_G0284201", "Q54K33", "DDB_G0287629", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "Q54XV3", "DDB_G0278711", "Q54GP1", "DDB_G0290025", "Q54GP1", "DDB_G0290025", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "Q54XV3", "DDB_G0278711", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q9XZJ3", "DDB_G0267384", "O60999", "DDB_G0291972", "Q54XF7", "DDB_G0278991", "Q54J43", "DDB_G0288307", "Q54X83", "DDB_G0279139", "Q54Q05", "DDB_G0284201", "Q54K33", "DDB_G0287629" ] }, "reaction_10623977": { "compartment": "compartment_70101", "id": "reaction_10623977", "reactome": "R-DDI-8955241", "name": "CAND1 binds cytosolic CRL E3 ubiquitin ligases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623973", "species_10611216" ], "products": [ "species_10623975" ], "modifiers": [], "additional_components": [ "O60999", "DDB_G0291972", "Q9XZJ3", "DDB_G0267384", "Q54XF7", "DDB_G0278991", "Q54PM1", "DDB_G0284461", "Q54Q05", "DDB_G0284201", "Q54K33", "DDB_G0287629", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54LV9", "DDB_G0286387", "Q55BF8", "DDB_G0271372", "Q54DL2", "DDB_G0292144", "Q54D84", "DDB_G0292436", "Q86AD8", "DDB_G0271500", "Q54XA6", "DDB_G0279093", "Q54NZ5", "DDB_G0284903", "Q54J43", "DDB_G0288307", "Q54X83", "DDB_G0279139", "DDB_G0274167", "Q86KD1", "DDB_G0274167", "O60999", "DDB_G0291972", "Q9XZJ3", "DDB_G0267384", "Q54XF7", "DDB_G0278991", "Q54PM1", "DDB_G0284461", "Q54Q05", "DDB_G0284201", "Q54K33", "DDB_G0287629", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54LV9", "DDB_G0286387", "Q55BF8", "DDB_G0271372", "Q54DL2", "DDB_G0292144", "Q54D84", "DDB_G0292436", "Q86AD8", "DDB_G0271500", "Q54XA6", "DDB_G0279093", "Q54NZ5", "DDB_G0284903", "Q54J43", "DDB_G0288307", "Q54X83", "DDB_G0279139" ] }, "reaction_10623983": { "compartment": "compartment_7660", "id": "reaction_10623983", "reactome": "R-DDI-8955245", "name": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623979", "species_10623754" ], "products": [ "species_10623981" ], "modifiers": [], "additional_components": [ "DDB_G0274167", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54E28", "DDB_G0291832", "Q551N8", "DDB_G0276481", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54IY4", "DDB_G0288453", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q55DE3", "DDB_G0269686", "Q54MH6", "DDB_G0285847", "Q552R1", "DDB_G0275925", "Q54K33", "DDB_G0287629", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54E28", "DDB_G0291832", "Q551N8", "DDB_G0276481", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54IY4", "DDB_G0288453", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q55DE3", "DDB_G0269686", "Q54MH6", "DDB_G0285847", "Q552R1", "DDB_G0275925", "Q54K33", "DDB_G0287629", "Q86KD1", "DDB_G0274167" ] }, "reaction_10623823": { "compartment": "compartment_7660", "id": "reaction_10623823", "reactome": "R-DDI-8952639", "name": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623726", "species_10623780", "species_10623792" ], "products": [ "species_10623794" ], "modifiers": [], "additional_components": [ "Q54XV3", "DDB_G0278711", "Q54TI6", "DDB_G0281725", "Q54MP2", "DDB_G0285813", "Q54DR0", "DDB_G0292074", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54E28", "DDB_G0291832", "Q551N8", "DDB_G0276481", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54IY4", "DDB_G0288453", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q55DE3", "DDB_G0269686", "Q54MH6", "DDB_G0285847", "Q552R1", "DDB_G0275925", "Q54K33", "DDB_G0287629", "Q54MP2", "DDB_G0285813", "Q54DR0", "DDB_G0292074", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54E28", "DDB_G0291832", "Q551N8", "DDB_G0276481", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54IY4", "DDB_G0288453", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q55DE3", "DDB_G0269686", "Q54MH6", "DDB_G0285847", "Q552R1", "DDB_G0275925", "Q54K33", "DDB_G0287629", "Q54XV3", "DDB_G0278711", "Q54TI6", "DDB_G0281725" ] }, "reaction_10623821": { "compartment": "compartment_7660", "id": "reaction_10623821", "reactome": "R-DDI-8952638", "name": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623794" ], "products": [ "species_10623818", "species_10623796" ], "modifiers": [ [ "species_10623794", "catalyst" ] ], "additional_components": [ "Q54MP2", "DDB_G0285813", "Q54DR0", "DDB_G0292074", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54E28", "DDB_G0291832", "Q551N8", "DDB_G0276481", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54IY4", "DDB_G0288453", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q55DE3", "DDB_G0269686", "Q54MH6", "DDB_G0285847", "Q552R1", "DDB_G0275925", "Q54K33", "DDB_G0287629", "Q54XV3", "DDB_G0278711", "Q54TI6", "DDB_G0281725", "Q54MP2", "DDB_G0285813", "Q54DR0", "DDB_G0292074", "Q54XV3", "DDB_G0278711", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54E28", "DDB_G0291832", "Q551N8", "DDB_G0276481", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54IY4", "DDB_G0288453", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q55DE3", "DDB_G0269686", "Q54MH6", "DDB_G0285847", "Q552R1", "DDB_G0275925", "Q54K33", "DDB_G0287629", "DDB_G0281725", "Q54MP2", "DDB_G0285813", "Q54DR0", "DDB_G0292074", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54E28", "DDB_G0291832", "Q551N8", "DDB_G0276481", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54IY4", "DDB_G0288453", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q55DE3", "DDB_G0269686", "Q54MH6", "DDB_G0285847", "Q552R1", "DDB_G0275925", "Q54K33", "DDB_G0287629", "Q54XV3", "DDB_G0278711", "Q54TI6", "DDB_G0281725" ] }, "reaction_10623985": { "compartment": "compartment_7660", "id": "reaction_10623985", "reactome": "R-DDI-8955285", "name": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623981", "species_10623778" ], "products": [ "species_10623979", "species_10623780" ], "modifiers": [], "additional_components": [ "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54E28", "DDB_G0291832", "Q551N8", "DDB_G0276481", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54IY4", "DDB_G0288453", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q55DE3", "DDB_G0269686", "Q54MH6", "DDB_G0285847", "Q552R1", "DDB_G0275925", "Q54K33", "DDB_G0287629", "Q86KD1", "DDB_G0274167", "Q54MP2", "DDB_G0285813", "Q54DR0", "DDB_G0292074", "DDB_G0274167", "Q54MP2", "DDB_G0285813", "Q54DR0", "DDB_G0292074", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54E28", "DDB_G0291832", "Q551N8", "DDB_G0276481", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54IY4", "DDB_G0288453", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q55DE3", "DDB_G0269686", "Q54MH6", "DDB_G0285847", "Q552R1", "DDB_G0275925", "Q54K33", "DDB_G0287629" ] }, "reaction_10624084": { "compartment": "compartment_70101", "id": "reaction_10624084", "reactome": "R-DDI-8956099", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624075", "species_10624080" ], "products": [ "species_10624082" ], "modifiers": [], "additional_components": [ "Q54K33", "DDB_G0287629", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q54Q05", "DDB_G0284201", "O60999", "DDB_G0291972", "Q54XF7", "DDB_G0278991", "Q9XZJ3", "DDB_G0267384", "Q54XV3", "DDB_G0278711", "DDB_G0270358", "Q55BU7", "DDB_G0270358", "Q54K33", "DDB_G0287629", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q54Q05", "DDB_G0284201", "O60999", "DDB_G0291972", "Q54XF7", "DDB_G0278991", "Q9XZJ3", "DDB_G0267384", "Q54XV3", "DDB_G0278711" ] }, "reaction_10624090": { "compartment": "compartment_876", "id": "reaction_10624090", "reactome": "R-DDI-8956200", "name": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623695", "species_10623713" ], "products": [ "species_10623715" ], "modifiers": [], "additional_components": [ "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "DDB_G0290025", "Q54GP1", "DDB_G0290025", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813" ] }, "reaction_10623515": { "compartment": "compartment_70101", "id": "reaction_10623515", "reactome": "R-DDI-8951644", "name": "Release of mature NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611068" ], "products": [ "species_10611066", "species_10610849" ], "modifiers": [], "additional_components": [ "Q54T48", "DDB_G0282007", "Q54XV3", "DDB_G0278711", "DDB_G0278711", "DDB_G0282007" ] }, "reaction_10623993": { "compartment": "compartment_70101", "id": "reaction_10623993", "reactome": "R-DDI-8955289", "name": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623627", "species_10623975" ], "products": [ "species_10623991", "species_10611216" ], "modifiers": [], "additional_components": [ "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q86KD1", "DDB_G0274167", "O60999", "DDB_G0291972", "Q9XZJ3", "DDB_G0267384", "Q54XF7", "DDB_G0278991", "Q54PM1", "DDB_G0284461", "Q54Q05", "DDB_G0284201", "Q54K33", "DDB_G0287629", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54LV9", "DDB_G0286387", "Q55BF8", "DDB_G0271372", "Q54DL2", "DDB_G0292144", "Q54D84", "DDB_G0292436", "Q86AD8", "DDB_G0271500", "Q54XA6", "DDB_G0279093", "Q54NZ5", "DDB_G0284903", "Q54J43", "DDB_G0288307", "Q54X83", "DDB_G0279139", "O60999", "DDB_G0291972", "Q9XZJ3", "DDB_G0267384", "Q54XF7", "DDB_G0278991", "Q54PM1", "DDB_G0284461", "Q54Q05", "DDB_G0284201", "Q54K33", "DDB_G0287629", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q54LV9", "DDB_G0286387", "Q55BF8", "DDB_G0271372", "Q54DL2", "DDB_G0292144", "Q54D84", "DDB_G0292436", "Q86AD8", "DDB_G0271500", "Q54XA6", "DDB_G0279093", "Q54NZ5", "DDB_G0284903", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54J43", "DDB_G0288307", "Q54X83", "DDB_G0279139", "DDB_G0274167" ] }, "reaction_10624062": { "compartment": "compartment_70101", "id": "reaction_10624062", "reactome": "R-DDI-8956040", "name": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624049" ], "products": [ "species_10611066", "species_10624059" ], "modifiers": [ [ "species_10619704", "catalyst" ] ], "additional_components": [ "Q54Q05", "DDB_G0284201", "Q54K33", "DDB_G0287629", "Q54PM1", "DDB_G0284461", "O60999", "DDB_G0291972", "Q54XF7", "DDB_G0278991", "Q9XZJ3", "DDB_G0267384", "Q54XV3", "DDB_G0278711", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q54LV9", "DDB_G0286387", "Q55BF8", "DDB_G0271372", "Q54DL2", "DDB_G0292144", "Q54D84", "DDB_G0292436", "Q86AD8", "DDB_G0271500", "Q54XA6", "DDB_G0279093", "Q54NZ5", "DDB_G0284903", "Q54GP1", "DDB_G0290025", "Q54J43", "DDB_G0288307", "Q54X83", "DDB_G0279139", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "DDB_G0278711", "Q54GP1", "DDB_G0290025", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q54LV9", "DDB_G0286387", "Q55BF8", "DDB_G0271372", "Q54DL2", "DDB_G0292144", "Q54D84", "DDB_G0292436", "Q86AD8", "DDB_G0271500", "Q54XA6", "DDB_G0279093", "Q54NZ5", "DDB_G0284903", "Q9XZJ3", "DDB_G0267384", "Q54XF7", "DDB_G0278991", "Q54PM1", "DDB_G0284461", "Q54Q05", "DDB_G0284201", "Q54J43", "DDB_G0288307", "Q54X83", "DDB_G0279139", "Q75K24", "DDB_G0275471", "Q54C92", "DDB_G0293180", "Q54QX3", "DDB_G0283587", "Q55BD5", "DDB_G0271282", "Q54E53", "DDB_G0291848", "Q54HL6", "DDB_G0289361", "Q54PF3", "DDB_G0284597", "Q54B82", "DDB_G0293844" ] }, "reaction_10623679": { "compartment": "compartment_70101", "id": "reaction_10623679", "reactome": "R-DDI-8952044", "name": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623654" ], "products": [ "species_10623676", "species_10623557" ], "modifiers": [ [ "species_10623654", "catalyst" ] ], "additional_components": [ "Q54GP1", "DDB_G0290025", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "Q54XV3", "DDB_G0278711", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q9XZJ3", "DDB_G0267384", "O60999", "DDB_G0291972", "Q54XF7", "DDB_G0278991", "Q54J43", "DDB_G0288307", "Q54X83", "DDB_G0279139", "Q54Q05", "DDB_G0284201", "Q54K33", "DDB_G0287629", "Q54GP1", "DDB_G0290025", "Q54J43", "DDB_G0288307", "Q54X83", "DDB_G0279139", "Q54Q05", "DDB_G0284201", "Q54K33", "DDB_G0287629", "Q54XF7", "DDB_G0278991", "Q9XZJ3", "DDB_G0267384", "O60999", "DDB_G0291972", "Q54XV3", "DDB_G0278711", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q94490", "DDB_G0284865", "Q54J12", "DDB_G0288697", "Q54IK3", "DDB_G0288697", "Q54GP1", "DDB_G0290025", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "Q54XV3", "DDB_G0278711", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q9XZJ3", "DDB_G0267384", "O60999", "DDB_G0291972", "Q54XF7", "DDB_G0278991", "Q54J43", "DDB_G0288307", "Q54X83", "DDB_G0279139", "Q54Q05", "DDB_G0284201", "Q54K33", "DDB_G0287629" ] }, "reaction_10585332": { "compartment": "compartment_70101", "id": "reaction_10585332", "reactome": "R-DDI-174070", "name": "Association of Cdh1 with the APC/C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577382", "species_10577377" ], "products": [ "species_10577384" ], "modifiers": [], "additional_components": [ "DDB_G0287259", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54KM3", "DDB_G0287259" ] }, "reaction_10585450": { "compartment": "compartment_70101", "id": "reaction_10585450", "reactome": "R-DDI-174224", "name": "Dissociation of Cdc20 from APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585386" ], "products": [ "species_10583643", "species_10577377" ], "modifiers": [], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54MZ3", "DDB_G0285601", "DDB_G0285601", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021" ] }, "reaction_10587270": { "compartment": "compartment_7660", "id": "reaction_10587270", "reactome": "R-DDI-199839", "name": "AKT can phosphorylate RSK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10587243" ], "products": [ "species_113582", "species_10587247" ], "modifiers": [ [ "species_10587267", "catalyst" ] ], "additional_components": [ "DDB_G0277449", "DDB_G0277449", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795" ] }, "reaction_10603208": { "compartment": "compartment_7660", "id": "reaction_10603208", "reactome": "R-DDI-3788705", "name": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10585338" ], "products": [ "species_113582", "species_10585340" ], "modifiers": [ [ "species_10585338", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "P34112", "DDB_G0272813", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "P34112", "DDB_G0272813", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259" ] }, "reaction_10603227": { "compartment": "compartment_7660", "id": "reaction_10603227", "reactome": "R-DDI-3788724", "name": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603218", "species_10576865" ], "products": [ "species_10603224" ], "modifiers": [ [ "species_10603218", "catalyst" ] ], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259" ] }, "reaction_10603210": { "compartment": "compartment_7660", "id": "reaction_10603210", "reactome": "R-DDI-3788708", "name": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585336", "species_10576705" ], "products": [ "species_10585338" ], "modifiers": [], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "P34112", "DDB_G0272813", "P34112", "DDB_G0272813", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259" ] }, "reaction_10598257": { "compartment": "compartment_70101", "id": "reaction_10598257", "reactome": "R-DDI-1483222", "name": "ETA is phosphorylated to PETA by CHK/ETNK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1498751" ], "products": [ "species_29370", "species_428686" ], "modifiers": [ [ "species_10598254", "catalyst" ] ], "additional_components": [ "Q554D8", "DDB_G0275265", "Q869T9", "DDB_G0274955" ] }, "reaction_10598075": { "compartment": "compartment_12045", "id": "reaction_10598075", "reactome": "R-DDI-1482962", "name": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500603", "species_1500596" ], "products": [ "species_1500581", "species_109395" ], "modifiers": [ [ "species_10598072", "catalyst" ] ], "additional_components": [ "Q8T2Q6", "DDB_G0275235", "Q54XM0", "DDB_G0278947", "Q550W1", "DDB_G0276763", "Q55AQ3", "DDB_G0271794", "species_29926", "species_266099" ] }, "reaction_10598234": { "compartment": "compartment_12045", "id": "reaction_10598234", "reactome": "R-DDI-1483203", "name": "PA is dephosphorylated to DAG by LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426755" ], "products": [ "species_29372", "species_1500596" ], "modifiers": [ [ "species_10598231", "catalyst" ] ], "additional_components": [ "Q75JA1", "DDB_G0271730", "species_29926" ] }, "reaction_10598223": { "compartment": "compartment_12045", "id": "reaction_10598223", "reactome": "R-DDI-1483190", "name": "PETA and CTP are condensed to CDP-ETA by PCY2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428686", "species_110614" ], "products": [ "species_111294", "species_1500603" ], "modifiers": [ [ "species_10598220", "catalyst" ] ], "additional_components": [ "Q55BZ4", "DDB_G0270298" ] }, "reaction_10583607": { "compartment": "compartment_70101", "id": "reaction_10583607", "reactome": "R-DDI-141186", "name": "MAOA:FAD oxidatively deaminates of 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_209914", "species_29368" ], "products": [ "species_500604", "species_29382", "species_29408" ], "modifiers": [ [ "species_10583604", "catalyst" ] ], "additional_components": [ "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10589900": { "compartment": "compartment_5460", "id": "reaction_10589900", "reactome": "R-DDI-380608", "name": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_380598" ], "products": [ "species_113529", "species_380593", "species_29362" ], "modifiers": [ [ "species_10578724", "catalyst" ] ], "additional_components": [ "Q54FY3", "DDB_G0290479" ] }, "reaction_10583105": { "compartment": "compartment_70101", "id": "reaction_10583105", "reactome": "R-DDI-112037", "name": "Inactivation of PLC beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10582955" ], "products": [ "species_10583103", "species_29372", "species_10582859" ], "modifiers": [], "additional_components": [ "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438", "Q02158", "DDB_G0292736", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29420", "DDB_G0292736" ] }, "reaction_10592511": { "compartment": "compartment_70101", "id": "reaction_10592511", "reactome": "R-DDI-442749", "name": "CaMKK autophosphorylates in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10592503" ], "products": [ "species_113582", "species_10592508" ], "modifiers": [ [ "species_10592503", "catalyst" ] ], "additional_components": [ "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "species_74112", "Q55CW1", "DDB_G0270680", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "species_74112", "Q55CW1", "DDB_G0270680", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "species_74112", "Q55CW1", "DDB_G0270680" ] }, "reaction_10583076": { "compartment": "compartment_70101", "id": "reaction_10583076", "reactome": "R-DDI-111955", "name": "cAMP hydrolysis by Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10583073", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121" ] }, "reaction_10583078": { "compartment": "compartment_70101", "id": "reaction_10583078", "reactome": "R-DDI-111956", "name": "Calmodulin activates Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583073" ], "products": [ "species_10583073" ], "modifiers": [ [ "species_10583042", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121", "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917" ] }, "reaction_10583044": { "compartment": "compartment_876", "id": "reaction_10583044", "reactome": "R-DDI-111930", "name": "Adenylate cyclase produces cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_111294", "species_30389" ], "modifiers": [ [ "species_10583022", "catalyst" ], [ "species_10583042", "catalyst" ] ], "additional_components": [ "species_29926", "Q03100", "DDB_G0281545", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917" ] }, "reaction_10623546": { "compartment": "compartment_70101", "id": "reaction_10623546", "reactome": "R-DDI-8951727", "name": "cAMP binds PKA tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10582993" ], "products": [ "species_10582995" ], "modifiers": [], "additional_components": [ "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029", "P05987", "DDB_G0279413", "Q8MM62", "DDB_G0276027", "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029", "P05987", "DDB_G0279413", "Q8MM62", "DDB_G0276027", "species_30389" ] }, "reaction_10582958": { "compartment": "compartment_70101", "id": "reaction_10582958", "reactome": "R-DDI-111879", "name": "PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10582955", "catalyst" ] ], "additional_components": [ "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438", "Q02158", "DDB_G0292736" ] }, "reaction_10577793": { "compartment": "compartment_70101", "id": "reaction_10577793", "reactome": "R-DDI-70486", "name": "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29728" ], "products": [ "species_29370", "species_29800" ], "modifiers": [ [ "species_10577790", "catalyst" ] ], "additional_components": [ "species_29926", "Q9GPM4", "DDB_G0287595" ] }, "reaction_10589604": { "compartment": "compartment_70101", "id": "reaction_10589604", "reactome": "R-DDI-372843", "name": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_113544" ], "products": [ "species_113548", "species_198498" ], "modifiers": [ [ "species_10589601", "catalyst" ] ], "additional_components": [ "DDB_G0284225" ] }, "reaction_10586982": { "compartment": "compartment_70101", "id": "reaction_10586982", "reactome": "R-DDI-198508", "name": "malate + NAD+ <=> oxaloacetate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198498", "species_29360" ], "products": [ "species_70106", "species_76213", "species_73473" ], "modifiers": [ [ "species_10586979", "catalyst" ] ], "additional_components": [ "Q54GE6", "DDB_G0290207" ] }, "reaction_10577773": { "compartment": "compartment_70101", "id": "reaction_10577773", "reactome": "R-DDI-70479", "name": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30014", "species_29356" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10577770", "catalyst" ], [ "species_76577", "inhibitor" ] ], "additional_components": [ "Q6RYT0", "DDB_G0270836", "species_29926" ] }, "reaction_10589548": { "compartment": "compartment_70101", "id": "reaction_10589548", "reactome": "R-DDI-372448", "name": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_113553" ], "products": [ "species_29448", "species_113552" ], "modifiers": [ [ "species_10589543", "catalyst" ] ], "additional_components": [ "DDB_G0283329" ] }, "reaction_10589775": { "compartment": "compartment_70101", "id": "reaction_10589775", "reactome": "R-DDI-376851", "name": "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_198498" ], "products": [ "species_29406", "species_113544" ], "modifiers": [ [ "species_10586969", "catalyst" ] ], "additional_components": [ "Q54PY7", "DDB_G0284225" ] }, "reaction_10577775": { "compartment": "compartment_70101", "id": "reaction_10577775", "reactome": "R-DDI-70481", "name": "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29578" ], "products": [ "species_75970" ], "modifiers": [ [ "species_10577742", "catalyst" ] ], "additional_components": [ "Q869R8", "DDB_G0274471" ] }, "reaction_10577777": { "compartment": "compartment_70101", "id": "reaction_10577777", "reactome": "R-DDI-70482", "name": "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29800", "species_73473" ], "products": [ "species_29372", "species_29578", "species_29360" ], "modifiers": [ [ "species_10577732", "catalyst" ] ], "additional_components": [ "Q94469", "DDB_G0275153" ] }, "reaction_10578553": { "compartment": "compartment_70101", "id": "reaction_10578553", "reactome": "R-DDI-71445", "name": "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30485" ], "products": [ "species_29728" ], "modifiers": [ [ "species_10578550", "catalyst" ] ], "additional_components": [ "Q54NE6", "DDB_G0285311" ] }, "reaction_10577757": { "compartment": "compartment_70101", "id": "reaction_10577757", "reactome": "R-DDI-70475", "name": "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10577752", "catalyst" ] ], "additional_components": [ "Q5V9E9", "DDB_G0283673" ] }, "reaction_10586972": { "compartment": "compartment_70101", "id": "reaction_10586972", "reactome": "R-DDI-198440", "name": "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_113544" ], "products": [ "species_113594", "species_198498" ], "modifiers": [ [ "species_10586969", "catalyst" ] ], "additional_components": [ "Q54PY7", "DDB_G0284225" ] }, "reaction_10577628": { "compartment": "compartment_70101", "id": "reaction_10577628", "reactome": "R-DDI-70241", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_76213" ], "products": [ "species_29420", "species_113528", "species_29492" ], "modifiers": [ [ "species_10577625", "catalyst" ] ], "additional_components": [ "DDB_G0271904" ] }, "reaction_10577820": { "compartment": "compartment_70101", "id": "reaction_10577820", "reactome": "R-DDI-70494", "name": "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29492" ], "products": [ "species_30485" ], "modifiers": [ [ "species_10577817", "catalyst" ] ], "additional_components": [ "Q54RK5", "DDB_G0283137", "Q55F83", "DDB_G0268214", "species_29926" ] }, "reaction_10578556": { "compartment": "compartment_70101", "id": "reaction_10578556", "reactome": "R-DDI-71495", "name": "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29578", "species_75970" ], "products": [ "species_30014" ], "modifiers": [ [ "species_10577690", "catalyst" ] ], "additional_components": [ "Q86A67", "DDB_G0274375" ] }, "reaction_10589599": { "compartment": "compartment_5460", "id": "reaction_10589599", "reactome": "R-DDI-372819", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113573", "species_113587" ], "products": [ "species_372364", "species_113525", "species_29376" ], "modifiers": [ [ "species_10589596", "catalyst" ] ], "additional_components": [ "DDB_G0271904" ] }, "reaction_10577886": { "compartment": "compartment_5460", "id": "reaction_10577886", "reactome": "R-DDI-70613", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113587", "species_113552" ], "products": [ "species_113594", "species_113553" ], "modifiers": [ [ "species_10577869", "catalyst" ] ], "additional_components": [ "Q55F21", "DDB_G0268664" ] }, "reaction_10602325": { "compartment": "compartment_70101", "id": "reaction_10602325", "reactome": "R-DDI-3249379", "name": "p-S407-STAT6 is phosphorylated at Tyr641", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10602323" ], "products": [ "species_29370", "species_10602295" ], "modifiers": [], "additional_components": [ "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10602311": { "compartment": "compartment_70101", "id": "reaction_10602311", "reactome": "R-DDI-3249370", "name": "p-S407,Y641-STAT6 dimer migrates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602297" ], "products": [ "species_10602309" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638" ] }, "reaction_10602313": { "compartment": "compartment_70101", "id": "reaction_10602313", "reactome": "R-DDI-3249372", "name": "p-S407,Y641-STAT6 is dimerized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602295" ], "products": [ "species_10602297" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10597394": { "compartment": "compartment_876", "id": "reaction_10597394", "reactome": "R-DDI-1296348", "name": "Activation of TWIK-related K+ channel (TREK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10597391", "catalyst" ] ], "additional_components": [ "Q86K40", "DDB_G0277255", "Q8T268", "DDB_G0277255" ] }, "reaction_10598007": { "compartment": "compartment_12045", "id": "reaction_10598007", "reactome": "R-DDI-1482816", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[6]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10598004", "catalyst" ] ], "additional_components": [ "DDB_G0283551" ] }, "reaction_10597944": { "compartment": "compartment_12045", "id": "reaction_10597944", "reactome": "R-DDI-1482547", "name": "1-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524028", "species_1500578" ], "products": [ "species_426925", "species_76194" ], "modifiers": [ [ "species_10597927", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541", "Q54X10", "DDB_G0279277" ] }, "reaction_10597930": { "compartment": "compartment_12045", "id": "reaction_10597930", "reactome": "R-DDI-1482533", "name": "2-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_975614" ], "products": [ "species_426925", "species_76194" ], "modifiers": [ [ "species_10597927", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541", "Q54X10", "DDB_G0279277" ] }, "reaction_10621983": { "compartment": "compartment_12045", "id": "reaction_10621983", "reactome": "R-DDI-8874435", "name": "THEM86B hydrolyses PMCHO, PMETAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8874447" ], "products": [ "species_8874450", "species_5696116" ], "modifiers": [ [ "species_10621980", "catalyst" ] ], "additional_components": [ "CHEBI:17810", "CHEBI:17476", "CHEBI:36313", "CHEBI:36314", "DDB_G0275665" ] }, "reaction_10598014": { "compartment": "compartment_12045", "id": "reaction_10598014", "reactome": "R-DDI-1482856", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[5]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10597959", "catalyst" ] ], "additional_components": [ "DDB_G0284449" ] }, "reaction_10582832": { "compartment": "compartment_7660", "id": "reaction_10582832", "reactome": "R-DDI-111437", "name": "Cleavage of the 3'-end of the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582828" ], "products": [ "species_10582830", "species_10582465" ], "modifiers": [], "additional_components": [ "Q55A45", "DDB_G0272320", "C7G054", "DDB_G0302414", "Q86L45", "DDB_G0273003", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q54RX0", "DDB_G0282863", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q55A45", "DDB_G0272320", "C7G054", "DDB_G0302414", "Q86L45", "DDB_G0273003", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q54RX0", "DDB_G0282863" ] }, "reaction_10582834": { "compartment": "compartment_7660", "id": "reaction_10582834", "reactome": "R-DDI-111438", "name": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582432", "species_10582465" ], "products": [ "species_10582828" ], "modifiers": [], "additional_components": [ "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q55A45", "DDB_G0272320", "C7G054", "DDB_G0302414", "Q86L45", "DDB_G0273003", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "C7G054", "DDB_G0302414", "Q86L45", "DDB_G0273003", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q54RX0", "DDB_G0282863", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197" ] }, "reaction_10627229": { "compartment": "compartment_7660", "id": "reaction_10627229", "reactome": "R-DDI-9671145", "name": "DKC1 binds SHQ1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627225", "species_10584005" ], "products": [ "species_10627227" ], "modifiers": [], "additional_components": [ "DDB_G0269304", "DDB_G0281933", "Q54T81", "DDB_G0281933", "Q55EC4", "DDB_G0269304" ] }, "reaction_10600850": { "compartment": "compartment_7660", "id": "reaction_10600850", "reactome": "R-DDI-2294580", "name": "PLK1 hyperphosphorylates Condensin II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10600834" ], "products": [ "species_113582", "species_10600847" ], "modifiers": [ [ "species_10600834", "catalyst" ] ], "additional_components": [ "Q86HN7", "DDB_G0274503", "Q76NW2", "DDB_G0276863", "Q54PK4", "DDB_G0284499", "Q54ID6", "DDB_G0288819", "Q54DZ9", "DDB_G0291894", "Q54LV0", "DDB_G0286403", "Q54XY3", "DDB_G0278701", "Q86HN7", "DDB_G0274503", "Q76NW2", "DDB_G0276863", "Q54PK4", "DDB_G0284499", "Q54XY3", "DDB_G0278701", "Q54ID6", "DDB_G0288819", "Q54DZ9", "DDB_G0291894", "Q54LV0", "DDB_G0286403", "Q86HN7", "DDB_G0274503", "Q76NW2", "DDB_G0276863", "Q54PK4", "DDB_G0284499", "Q54ID6", "DDB_G0288819", "Q54DZ9", "DDB_G0291894", "Q54LV0", "DDB_G0286403", "Q54XY3", "DDB_G0278701" ] }, "reaction_10600854": { "compartment": "compartment_7660", "id": "reaction_10600854", "reactome": "R-DDI-2294590", "name": "PLK1 binds phosphorylated condensin II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600852", "species_10583697" ], "products": [ "species_10600834" ], "modifiers": [], "additional_components": [ "Q54PK4", "DDB_G0284499", "Q54ID6", "DDB_G0288819", "Q54DZ9", "DDB_G0291894", "Q54LV0", "DDB_G0286403", "Q54XY3", "DDB_G0278701", "Q76NW2", "DDB_G0276863", "DDB_G0274503", "Q86HN7", "DDB_G0274503", "Q76NW2", "DDB_G0276863", "Q54PK4", "DDB_G0284499", "Q54ID6", "DDB_G0288819", "Q54DZ9", "DDB_G0291894", "Q54LV0", "DDB_G0286403", "Q54XY3", "DDB_G0278701" ] }, "reaction_10600826": { "compartment": "compartment_7660", "id": "reaction_10600826", "reactome": "R-DDI-2288097", "name": "Condensin II complex binds H4K20me1-containing nucleosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600587", "species_10600624" ], "products": [ "species_10600824" ], "modifiers": [ [ "species_10600589", "catalyst" ] ], "additional_components": [ "Q54PK4", "DDB_G0284499", "Q54ID6", "DDB_G0288819", "Q54DZ9", "DDB_G0291894", "Q54LV0", "DDB_G0286403", "Q54XY3", "DDB_G0278701", "Q76NW2", "DDB_G0276863", "Q76NW2", "DDB_G0276863", "Q54PK4", "DDB_G0284499", "Q54ID6", "DDB_G0288819", "Q54DZ9", "DDB_G0291894", "Q54LV0", "DDB_G0286403", "Q54XY3", "DDB_G0278701", "Q54FX2", "DDB_G0290551", "Q54PK4", "DDB_G0284499", "Q54ID6", "DDB_G0288819", "Q54DZ9", "DDB_G0291894", "Q54LV0", "DDB_G0286403", "Q54XY3", "DDB_G0278701" ] }, "reaction_10600637": { "compartment": "compartment_7660", "id": "reaction_10600637", "reactome": "R-DDI-2172678", "name": "PHF8 demethylates histone H4K20me1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600630", "species_113671", "species_113685" ], "products": [ "species_10600634", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10600630", "catalyst" ] ], "additional_components": [ "Q76NW2", "DDB_G0276863", "species_71067", "species_71067", "Q76NW2", "DDB_G0276863", "Q76NW2", "DDB_G0276863", "species_71067" ] }, "reaction_10600591": { "compartment": "compartment_7660", "id": "reaction_10600591", "reactome": "R-DDI-2172666", "name": "RB1 binds condensin II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577547", "species_10600587" ], "products": [ "species_10600589" ], "modifiers": [], "additional_components": [ "DDB_G0290551", "Q54PK4", "DDB_G0284499", "Q54ID6", "DDB_G0288819", "Q54DZ9", "DDB_G0291894", "Q54LV0", "DDB_G0286403", "Q54XY3", "DDB_G0278701", "Q54FX2", "DDB_G0290551", "Q54PK4", "DDB_G0284499", "Q54ID6", "DDB_G0288819", "Q54DZ9", "DDB_G0291894", "Q54LV0", "DDB_G0286403", "Q54XY3", "DDB_G0278701" ] }, "reaction_10595203": { "compartment": "compartment_70101", "id": "reaction_10595203", "reactome": "R-DDI-939265", "name": "Activation of Rap1 by membrane-associated GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10589459" ], "products": [ "species_29420", "species_10589457" ], "modifiers": [ [ "species_10590642", "catalyst" ] ], "additional_components": [ "species_29420", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "species_29438", "Q54TK8", "DDB_G0281573", "Q8IS12", "DDB_G0275703" ] }, "reaction_10589538": { "compartment": "compartment_70101", "id": "reaction_10589538", "reactome": "R-DDI-354173", "name": "Activation of Rap1 by cytosolic GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10589459" ], "products": [ "species_29420", "species_10589457" ], "modifiers": [ [ "species_10589535", "catalyst" ] ], "additional_components": [ "species_29420", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "species_29438", "species_74112", "species_6797635", "Q55FD8", "DDB_G0268578", "Q55GH9", "DDB_G0267666", "Q8IS11", "DDB_G0290267", "Q8IS14", "DDB_G0277913", "Q8IS15", "DDB_G0277915", "Q8IS16", "DDB_G0276963", "Q8IS20", "DDB_G0282381", "Q8IS21", "DDB_G0269222", "Q8SSQ0", "DDB_G0274605", "Q8SSW7", "DDB_G0271868", "B0M0P8", "DDB_G0276371", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q54FF3", "DDB_G0290901", "Q54H95", "DDB_G0289613", "Q54PQ4", "DDB_G0284329", "Q54XL4", "DDB_G0289613" ] }, "reaction_10600085": { "compartment": "compartment_12045", "id": "reaction_10600085", "reactome": "R-DDI-2046093", "name": "Translocation of tetracosapentaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046050", "species_211579" ], "products": [ "species_5228339", "species_2046055", "species_211606" ], "modifiers": [ [ "species_10590195", "catalyst" ] ], "additional_components": [ "DDB_G0293194" ] }, "reaction_10600087": { "compartment": "compartment_17957", "id": "reaction_10600087", "reactome": "R-DDI-2046094", "name": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046042", "species_113601" ], "products": [ "species_113519", "species_113564", "species_162743", "species_159751", "species_2046045" ], "modifiers": [ [ "species_10593966", "catalyst" ] ], "additional_components": [ "Q55BY4", "DDB_G0271066", "C7FZW5", "DDB_G0271066" ] }, "reaction_10600071": { "compartment": "compartment_12045", "id": "reaction_10600071", "reactome": "R-DDI-2046083", "name": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046053", "species_113601" ], "products": [ "species_113519", "species_162743", "species_159751", "species_2046060" ], "modifiers": [ [ "species_10593964", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10600089": { "compartment": "compartment_17957", "id": "reaction_10600089", "reactome": "R-DDI-2046095", "name": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046060", "species_113601" ], "products": [ "species_2046048", "species_113519", "species_162743", "species_159751" ], "modifiers": [ [ "species_10593964", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10600091": { "compartment": "compartment_12045", "id": "reaction_10600091", "reactome": "R-DDI-2046098", "name": "Activation of linoleic acid to linoleoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211579", "species_162743", "species_2046044" ], "products": [ "species_2046064", "species_2046049", "species_2046063" ], "modifiers": [ [ "species_10600073", "catalyst" ] ], "additional_components": [ "species_29926", "Q54JK0", "DDB_G0288001", "Q55DR6", "DDB_G0269242", "Q1ZXQ4", "DDB_G0269474" ] }, "reaction_10599749": { "compartment": "compartment_20699", "id": "reaction_10599749", "reactome": "R-DDI-2022887", "name": "NDST1-4 N-deacetylates GlcNAc residues in heparan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2022884", "species_10599746" ], "products": [ "species_10599718", "species_2022890" ], "modifiers": [ [ "species_10599730", "catalyst" ] ], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488", "DDB_G0267630" ] }, "reaction_10599739": { "compartment": "compartment_20699", "id": "reaction_10599739", "reactome": "R-DDI-2022860", "name": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10599718" ], "products": [ "species_10599725", "species_742343" ], "modifiers": [ [ "species_10599730", "catalyst" ] ], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488", "DDB_G0267630" ] }, "reaction_10600141": { "compartment": "compartment_20699", "id": "reaction_10600141", "reactome": "R-DDI-2076611", "name": "HS3STs sulfate GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10599765" ], "products": [ "species_10599772", "species_742343" ], "modifiers": [ [ "species_10600128", "catalyst" ] ], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488", "DDB_G0267630" ] }, "reaction_10599821": { "compartment": "compartment_17963", "id": "reaction_10599821", "reactome": "R-DDI-2024108", "name": "Some HSPGs are secreted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599787" ], "products": [ "species_10599819" ], "modifiers": [], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488" ] }, "reaction_10600126": { "compartment": "compartment_17963", "id": "reaction_10600126", "reactome": "R-DDI-2076383", "name": "HS3ST1 sulfates GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10599765" ], "products": [ "species_10599772", "species_742343" ], "modifiers": [ [ "species_10600121", "catalyst" ] ], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488", "DDB_G0267630" ] }, "reaction_10599661": { "compartment": "compartment_20699", "id": "reaction_10599661", "reactome": "R-DDI-1878002", "name": "XYLTs transfer Xyl to core protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599635", "species_742361" ], "products": [ "species_10599642", "species_205687" ], "modifiers": [ [ "species_10599658", "catalyst" ] ], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488", "Q55F91", "DDB_G0269558", "Q55DR5", "DDB_G0269558" ] }, "reaction_10600145": { "compartment": "compartment_161320", "id": "reaction_10600145", "reactome": "R-DDI-2090038", "name": "NAGLU hydrolyses heparan chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090053" ], "products": [ "species_1678743", "species_2065212" ], "modifiers": [ [ "species_10599153", "catalyst" ] ], "additional_components": [ "DDB_G0291998" ] }, "reaction_10600147": { "compartment": "compartment_161320", "id": "reaction_10600147", "reactome": "R-DDI-2090079", "name": "GLB1 hydrolyses linker chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090075" ], "products": [ "species_1605637", "species_2090063" ], "modifiers": [ [ "species_10598338", "catalyst" ] ], "additional_components": [ "DDB_G0290217" ] }, "reaction_10600149": { "compartment": "compartment_17938", "id": "reaction_10600149", "reactome": "R-DDI-2090085", "name": "HGSNAT oligomer acetylates Heparan chain(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183", "species_2090045" ], "products": [ "species_2090053", "species_76194" ], "modifiers": [ [ "species_10599125", "catalyst" ] ], "additional_components": [ "Q54LX9", "DDB_G0286315" ] }, "reaction_10599156": { "compartment": "compartment_161320", "id": "reaction_10599156", "reactome": "R-DDI-1678742", "name": "NAGLU hydrolyses Heparan sulfate chain(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090069" ], "products": [ "species_2090080", "species_1678743" ], "modifiers": [ [ "species_10599153", "catalyst" ] ], "additional_components": [ "DDB_G0291998" ] }, "reaction_10599751": { "compartment": "compartment_876", "id": "reaction_10599751", "reactome": "R-DDI-2024084", "name": "HS-GAGs translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599134" ], "products": [ "species_10598515" ], "modifiers": [], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488" ] }, "reaction_10599128": { "compartment": "compartment_17938", "id": "reaction_10599128", "reactome": "R-DDI-1678660", "name": "HGSNAT oligomer acetylates Heparan sulfate chain(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2090040", "species_76183" ], "products": [ "species_2090069", "species_76194" ], "modifiers": [ [ "species_10599125", "catalyst" ] ], "additional_components": [ "Q54LX9", "DDB_G0286315" ] }, "reaction_10599148": { "compartment": "compartment_161320", "id": "reaction_10599148", "reactome": "R-DDI-1678716", "name": "IDUA hydrolyses Heparan sulfate chain(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2090033", "species_1605715" ], "products": [ "species_2090072", "species_1678617" ], "modifiers": [ [ "species_10599145", "catalyst" ] ], "additional_components": [ "DDB_G0288289" ] }, "reaction_10600143": { "compartment": "compartment_161320", "id": "reaction_10600143", "reactome": "R-DDI-2090037", "name": "IDUA hydrolyses Heparan sulfate chain(6)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090055" ], "products": [ "species_2090070", "species_1678617" ], "modifiers": [ [ "species_10599145", "catalyst" ] ], "additional_components": [ "DDB_G0288289" ] }, "reaction_10593201": { "compartment": "compartment_70101", "id": "reaction_10593201", "reactome": "R-DDI-450358", "name": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037" ], "products": [ "species_10584754" ], "modifiers": [ [ "species_10593152", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54C11", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "P11467", "DDB_G0290961", "Q86L54", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q54LU8", "DDB_G0286465" ] }, "reaction_10617650": { "compartment": "compartment_12045", "id": "reaction_10617650", "reactome": "R-DDI-6811425", "name": "NSF and SNAPs bind cis-SNARE at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611694", "species_10611703", "species_10617648" ], "products": [ "species_10617536" ], "modifiers": [], "additional_components": [ "Q75JI3", "DDB_G0276153", "Q54NP6", "DDB_G0285111", "Q55CR0", "DDB_G0269942", "Q55GJ4", "DDB_G0267646", "Q54TZ2", "DDB_G0281429", "Q54LH0", "DDB_G0286811", "Q55CR0", "DDB_G0269942", "Q54NP6", "DDB_G0285111", "Q55GJ4", "DDB_G0267646", "Q54TZ2", "DDB_G0281429", "Q54LH0", "DDB_G0286811", "Q75JI3", "DDB_G0276153" ] }, "reaction_10617491": { "compartment": "compartment_20699", "id": "reaction_10617491", "reactome": "R-DDI-6811415", "name": "RAB:GTP recruits GBF1 to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617199", "species_10616771" ], "products": [ "species_10617489" ], "modifiers": [], "additional_components": [ "species_29438", "Q552K3", "DDB_G0275969", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "Q558I0", "DDB_G0272905", "P34141", "DDB_G0291233", "P34140", "DDB_G0277867", "Q54EW9", "DDB_G0291293", "P34143", "DDB_G0271736", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "species_29438", "Q552K3", "DDB_G0275969", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "Q558I0", "DDB_G0272905", "P34141", "DDB_G0291233", "P34140", "DDB_G0277867", "Q54EW9", "DDB_G0291293", "P34143", "DDB_G0271736" ] }, "reaction_10617507": { "compartment": "compartment_20699", "id": "reaction_10617507", "reactome": "R-DDI-6811417", "name": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617503", "species_10616863", "species_10617497", "species_10617495", "species_10617233" ], "products": [ "species_10617505" ], "modifiers": [], "additional_components": [ "Q86JE5", "DDB_G0272124", "Q769F9", "DDB_G0288053", "Q54BN0", "DDB_G0293540", "Q556J9", "DDB_G0272889", "Q769F6", "DDB_G0277923", "Q769F7", "DDB_G0278969", "Q54DK9", "DDB_G0292148", "Q54TP9", "DDB_G0292148", "DDB_G0269942", "species_29438", "Q54X30", "DDB_G0290771", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q552K3", "DDB_G0275969", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "Q558I0", "DDB_G0272905", "P34141", "DDB_G0291233", "P34140", "DDB_G0277867", "Q54EW9", "DDB_G0291293", "P34143", "DDB_G0271736", "Q55EZ6", "DDB_G0268702", "Q23924", "DDB_G0284735", "Q54HL0", "DDB_G0289371", "Q54CA7", "DDB_G0293086", "Q54HD4", "DDB_G0289523", "Q54YD8", "DDB_G0278285", "Q55FU2", "DDB_G0267950", "Q55FR9", "DDB_G0267982", "Q769F9", "DDB_G0288053", "Q54BN0", "DDB_G0293540", "Q769F6", "DDB_G0277923", "Q769F7", "DDB_G0278969", "Q769F9", "DDB_G0288053", "Q54BN0", "DDB_G0293540", "Q769F6", "DDB_G0277923", "Q769F7", "DDB_G0278969", "species_29438", "Q54X30", "DDB_G0290771", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q552K3", "DDB_G0275969", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "Q558I0", "DDB_G0272905", "P34141", "DDB_G0291233", "P34140", "DDB_G0277867", "Q54EW9", "DDB_G0291293", "P34143", "DDB_G0271736", "Q55EZ6", "DDB_G0268702", "Q23924", "DDB_G0284735", "Q54HL0", "DDB_G0289371", "Q54CA7", "DDB_G0293086", "Q54HD4", "DDB_G0289523", "Q54YD8", "DDB_G0278285", "Q55FU2", "DDB_G0267950", "Q55FR9", "DDB_G0267982", "Q55CR0", "DDB_G0269942", "Q54DK9", "DDB_G0292148", "Q54TP9", "DDB_G0292148", "Q86JE5", "DDB_G0272124", "Q556J9", "DDB_G0272889" ] }, "reaction_10617539": { "compartment": "compartment_12045", "id": "reaction_10617539", "reactome": "R-DDI-6811422", "name": "NSF ATPase activity dissociates cis-SNARE at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10617536" ], "products": [ "species_10611694", "species_10617532", "species_29372", "species_10611703", "species_10617527", "species_10587872", "species_10617522" ], "modifiers": [ [ "species_10617536", "catalyst" ] ], "additional_components": [ "Q55CR0", "DDB_G0269942", "Q54NP6", "DDB_G0285111", "Q55GJ4", "DDB_G0267646", "Q54TZ2", "DDB_G0281429", "Q54LH0", "DDB_G0286811", "Q75JI3", "DDB_G0276153", "Q75JI3", "DDB_G0276153", "DDB_G0286811", "Q54NP6", "DDB_G0285111", "DDB_G0281429", "DDB_G0269942", "DDB_G0267646", "Q55CR0", "DDB_G0269942", "Q54NP6", "DDB_G0285111", "Q55GJ4", "DDB_G0267646", "Q54TZ2", "DDB_G0281429", "Q54LH0", "DDB_G0286811", "Q75JI3", "DDB_G0276153" ] }, "reaction_10617652": { "compartment": "compartment_12045", "id": "reaction_10617652", "reactome": "R-DDI-6811427", "name": "COPI vesicle uncoating at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617646" ], "products": [ "species_10617644", "species_10616843", "species_10617604", "species_10617648", "species_10611571" ], "modifiers": [], "additional_components": [ "Q54EW9", "DDB_G0291293", "P34143", "DDB_G0271736", "Q552K3", "DDB_G0275969", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "Q558I0", "DDB_G0272905", "P34141", "DDB_G0291233", "P34140", "DDB_G0277867", "species_29438", "Q55FR9", "DDB_G0267982", "Q55FU2", "DDB_G0267950", "Q54YD8", "DDB_G0278285", "Q54CA7", "DDB_G0293086", "Q54HD4", "DDB_G0289523", "Q54HL0", "DDB_G0289371", "Q23924", "DDB_G0284735", "Q55EZ6", "DDB_G0268702", "Q55CR0", "DDB_G0269942", "Q769F7", "DDB_G0278969", "Q54BN0", "DDB_G0293540", "Q769F9", "DDB_G0288053", "Q769F6", "DDB_G0277923", "Q55CJ0", "DDB_G0270040", "Q55CA1", "DDB_G0270150", "Q54YZ1", "DDB_G0277997", "Q55GJ4", "DDB_G0267646", "Q54TZ2", "DDB_G0281429", "Q54LH0", "DDB_G0286811", "Q86JE5", "DDB_G0272124", "Q556J9", "DDB_G0272889", "Q86JE5", "DDB_G0272124", "Q769F7", "DDB_G0278969", "Q54BN0", "DDB_G0293540", "Q769F9", "DDB_G0288053", "Q769F6", "DDB_G0277923", "Q556J9", "DDB_G0272889", "Q55EZ6", "DDB_G0268702", "Q23924", "DDB_G0284735", "Q54HL0", "DDB_G0289371", "Q54CA7", "DDB_G0293086", "Q54HD4", "DDB_G0289523", "Q54YD8", "DDB_G0278285", "Q55FU2", "DDB_G0267950", "Q55FR9", "DDB_G0267982", "Q769F7", "DDB_G0278969", "Q54BN0", "DDB_G0293540", "Q769F9", "DDB_G0288053", "Q769F6", "DDB_G0277923", "Q55CR0", "DDB_G0269942", "Q55GJ4", "DDB_G0267646", "Q54TZ2", "DDB_G0281429", "Q54LH0", "DDB_G0286811", "P34139", "DDB_G0283757", "species_29420" ] }, "reaction_10618658": { "compartment": "compartment_12045", "id": "reaction_10618658", "reactome": "R-DDI-8850041", "name": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10618647" ], "products": [ "species_10618655", "species_29420" ], "modifiers": [ [ "species_10618647", "catalyst" ] ], "additional_components": [ "Q54UJ4", "DDB_G0281043", "Q54DM6", "DDB_G0292124", "Q54GY8", "DDB_G0289827", "species_29420", "Q54UJ4", "DDB_G0281043", "Q54DM6", "DDB_G0292124", "Q54GY8", "DDB_G0289827", "species_29438", "Q54UJ4", "DDB_G0281043", "Q54DM6", "DDB_G0292124", "Q54GY8", "DDB_G0289827", "species_29420" ] }, "reaction_10618649": { "compartment": "compartment_12045", "id": "reaction_10618649", "reactome": "R-DDI-8850040", "name": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618633", "species_10618645" ], "products": [ "species_10618647" ], "modifiers": [], "additional_components": [ "Q54GY8", "DDB_G0289827", "species_29420", "Q54UJ4", "DDB_G0281043", "Q54DM6", "DDB_G0292124", "Q54UJ4", "DDB_G0281043", "Q54DM6", "DDB_G0292124", "Q54GY8", "DDB_G0289827", "species_29420" ] }, "reaction_10618509": { "compartment": "compartment_20699", "id": "reaction_10618509", "reactome": "R-DDI-8849345", "name": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_548819", "species_8848483" ], "products": [ "species_429785", "species_76194" ], "modifiers": [ [ "species_10618506", "catalyst" ] ], "additional_components": [ "DDB_G0288863" ] }, "reaction_10589211": { "compartment": "compartment_70101", "id": "reaction_10589211", "reactome": "R-DDI-350598", "name": "Arginine<=>Agmatine+CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468" ], "products": [ "species_113528", "species_351164" ], "modifiers": [ [ "species_10589208", "catalyst" ] ], "additional_components": [ "DDB_G0281109" ] }, "reaction_10590640": { "compartment": "compartment_17940", "id": "reaction_10590640", "reactome": "R-DDI-392749", "name": "Transport of L1 into endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590638" ], "products": [ "species_10590638" ], "modifiers": [], "additional_components": [ "Q54F41", "DDB_G0291131", "Q54DN5", "DDB_G0291984", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54H39", "DDB_G0289721", "Q54X82", "DDB_G0279141", "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "Q54F41", "DDB_G0291131", "Q54DN5", "DDB_G0291984", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54H39", "DDB_G0289721", "Q54X82", "DDB_G0279141", "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139" ] }, "reaction_10594030": { "compartment": "compartment_876", "id": "reaction_10594030", "reactome": "R-DDI-555065", "name": "Formation of clathrin coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10585860", "species_10594019" ], "products": [ "species_10590638", "species_29372", "species_29420" ], "modifiers": [ [ "species_10594027", "catalyst" ] ], "additional_components": [ "Q54F41", "DDB_G0291131", "Q54DN5", "DDB_G0291984", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54H39", "DDB_G0289721", "Q54X82", "DDB_G0279141", "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "Q54F41", "DDB_G0291131", "Q54DN5", "DDB_G0291984", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54H39", "DDB_G0289721", "Q54X82", "DDB_G0279141", "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139" ] }, "reaction_10611540": { "compartment": "compartment_5460", "id": "reaction_10611540", "reactome": "R-DDI-5693977", "name": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611519", "species_200671" ], "products": [ "species_10611532", "species_5693978", "species_5693984" ], "modifiers": [ [ "species_10611537", "catalyst" ] ], "additional_components": [ "Q54JV8", "DDB_G0287773", "CHEBI:14949", "CHEBI:50746", "Q54JV8", "DDB_G0287773", "DDB_G0292326" ] }, "reaction_10611545": { "compartment": "compartment_5460", "id": "reaction_10611545", "reactome": "R-DDI-5694018", "name": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611532", "species_113526" ], "products": [ "species_10611515", "species_113529", "species_29362" ], "modifiers": [ [ "species_10611542", "catalyst" ] ], "additional_components": [ "CHEBI:50746", "Q54JV8", "DDB_G0287773", "DDB_G0287773", "Q54EW8", "DDB_G0291648", "species_113596" ] }, "reaction_10611530": { "compartment": "compartment_5460", "id": "reaction_10611530", "reactome": "R-DDI-5693967", "name": "PXLP-K754-GLDC dimer decarboxylates Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_10611515" ], "products": [ "species_10611519", "species_29376" ], "modifiers": [ [ "species_10611527", "catalyst" ] ], "additional_components": [ "DDB_G0287773", "Q54JV8", "DDB_G0287773", "CHEBI:14949", "Q54KM7", "DDB_G0287255" ] }, "reaction_10590766": { "compartment": "compartment_70101", "id": "reaction_10590766", "reactome": "R-DDI-418456", "name": "cGMP is degraded by PDEs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30991" ], "products": [ "species_113578" ], "modifiers": [ [ "species_10590763", "catalyst" ] ], "additional_components": [ "B0G0Y8", "DDB_G0268634", "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121" ] }, "reaction_10590749": { "compartment": "compartment_70101", "id": "reaction_10590749", "reactome": "R-DDI-418436", "name": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468", "species_29368", "species_29364" ], "products": [ "species_202124", "species_29366", "species_29968" ], "modifiers": [ [ "species_10590744", "catalyst" ] ], "additional_components": [ "DDB_G0269912" ] }, "reaction_10618498": { "compartment": "compartment_12045", "id": "reaction_10618498", "reactome": "R-DDI-8848585", "name": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200993", "species_30209" ], "products": [ "species_76194", "species_2534407" ], "modifiers": [ [ "species_10611937", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10590501": { "compartment": "compartment_17951", "id": "reaction_10590501", "reactome": "R-DDI-390425", "name": "FAR1 reduces PalmCoA to HXOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200993" ], "products": [ "species_29366", "species_8848577", "species_76194" ], "modifiers": [ [ "species_10590498", "catalyst" ] ], "additional_components": [ "DDB_G0289081" ] }, "reaction_10590503": { "compartment": "compartment_17951", "id": "reaction_10590503", "reactome": "R-DDI-390438", "name": "FAR2 reduces PalmCoA to HXOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200993" ], "products": [ "species_29366", "species_8848577", "species_76194" ], "modifiers": [ [ "species_10590498", "catalyst" ] ], "additional_components": [ "DDB_G0289081" ] }, "reaction_10618495": { "compartment": "compartment_12045", "id": "reaction_10618495", "reactome": "R-DDI-8848582", "name": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848577", "species_200993" ], "products": [ "species_8848499", "species_76194" ], "modifiers": [ [ "species_10611937", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10611935": { "compartment": "compartment_12045", "id": "reaction_10611935", "reactome": "R-DDI-5696424", "name": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192172", "species_5696426" ], "products": [ "species_5696412", "species_162743" ], "modifiers": [ [ "species_10611932", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10588683": { "compartment": "compartment_70101", "id": "reaction_10588683", "reactome": "R-DDI-209828", "name": "Tryptophan is hydroxylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_29500", "species_29368" ], "products": [ "species_71112", "species_209911" ], "modifiers": [ [ "species_10588680", "catalyst" ] ], "additional_components": [ "Q54XS1", "DDB_G0278781", "species_71067" ] }, "reaction_10588667": { "compartment": "compartment_70101", "id": "reaction_10588667", "reactome": "R-DDI-209821", "name": "Methylation of N-acetyl-5-HT to form melatonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_209793" ], "products": [ "species_209934", "species_70106", "species_71285" ], "modifiers": [ [ "species_10588664", "catalyst" ] ], "additional_components": [ "Q86I40", "DDB_G0275013", "Q54B59", "DDB_G0293888", "Q54GZ0", "DDB_G0289823", "Q54S95", "DDB_G0282591", "Q8T638", "DDB_G0289329", "Q54B60", "DDB_G0293886", "Q54FP4", "DDB_G0290719", "Q86HS9", "DDB_G0274941" ] }, "reaction_10606827": { "compartment": "compartment_17938", "id": "reaction_10606827", "reactome": "R-DDI-5672010", "name": "Active MTORC1 phosphorylates ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10606817" ], "products": [ "species_29370", "species_10606824" ], "modifiers": [ [ "species_10606817", "catalyst" ] ], "additional_components": [ "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54J54", "DDB_G0288287", "Q86CS2", "DDB_G0292390", "Q55BY0", "DDB_G0269162", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390" ] }, "reaction_10607979": { "compartment": "compartment_12045", "id": "reaction_10607979", "reactome": "R-DDI-5682385", "name": "The phagophore extends from the PIP3-enriched structure", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606839" ], "products": [ "species_10607970" ], "modifiers": [ [ "species_10607975", "catalyst" ] ], "additional_components": [ "Q54JI9", "DDB_G0288021", "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "Q54JI9", "DDB_G0288021", "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "DDB_G0285323" ] }, "reaction_10626468": { "compartment": "compartment_70101", "id": "reaction_10626468", "reactome": "R-DDI-9641089", "name": "Parkin binds Ub:UBE2N:UBE2V1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596322", "species_10626464" ], "products": [ "species_10626466" ], "modifiers": [], "additional_components": [ "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043" ] }, "reaction_10626478": { "compartment": "compartment_70101", "id": "reaction_10626478", "reactome": "R-DDI-9641096", "name": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626474", "species_10626466" ], "products": [ "species_10626476" ], "modifiers": [], "additional_components": [ "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151" ] }, "reaction_10626510": { "compartment": "compartment_70101", "id": "reaction_10626510", "reactome": "R-DDI-9641127", "name": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626506" ], "products": [ "species_10626492" ], "modifiers": [], "additional_components": [ "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54U44", "DDB_G0280973", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54U44", "DDB_G0280973", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765" ] }, "reaction_10626494": { "compartment": "compartment_70101", "id": "reaction_10626494", "reactome": "R-DDI-9641109", "name": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626492" ], "products": [ "species_10626490", "species_10626480" ], "modifiers": [], "additional_components": [ "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54U44", "DDB_G0280973", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54U44", "DDB_G0280973", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596" ] }, "reaction_10626559": { "compartment": "compartment_18667", "id": "reaction_10626559", "reactome": "R-DDI-9646685", "name": "Aggresome dissociates from dynein and microtubule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626551" ], "products": [ "species_10626557", "species_10589898", "species_10605681" ], "modifiers": [], "additional_components": [ "P54703", "DDB_G0280849", "Q86A88", "DDB_G0274815", "Q54CI8", "DDB_G0292904", "P34036", "DDB_G0276355", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54U44", "DDB_G0280973", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54X15", "DDB_G0279267", "species_29438", "species_29420", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54U44", "DDB_G0280973", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54X15", "DDB_G0279267", "species_29438", "species_29420", "P54703", "DDB_G0280849", "Q86A88", "DDB_G0274815", "Q54CI8", "DDB_G0292904", "P34036", "DDB_G0276355" ] }, "reaction_10626508": { "compartment": "compartment_70101", "id": "reaction_10626508", "reactome": "R-DDI-9641111", "name": "Parkin transfers Ub to misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626476" ], "products": [ "species_10626506" ], "modifiers": [], "additional_components": [ "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54U44", "DDB_G0280973", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765" ] }, "reaction_10626541": { "compartment": "compartment_70101", "id": "reaction_10626541", "reactome": "R-DDI-9646348", "name": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626537", "species_10605681" ], "products": [ "species_10626539" ], "modifiers": [], "additional_components": [ "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54U44", "DDB_G0280973", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54X15", "DDB_G0279267", "P54703", "DDB_G0280849", "Q86A88", "DDB_G0274815", "Q54CI8", "DDB_G0292904", "P34036", "DDB_G0276355", "P54703", "DDB_G0280849", "Q86A88", "DDB_G0274815", "Q54CI8", "DDB_G0292904", "P34036", "DDB_G0276355", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54U44", "DDB_G0280973", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54X15", "DDB_G0279267" ] }, "reaction_10623347": { "compartment": "compartment_70101", "id": "reaction_10623347", "reactome": "R-DDI-8948039", "name": "FUNDC1 is phosphorylated by CK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623342", "species_113592" ], "products": [ "species_29370", "species_10623345" ], "modifiers": [ [ "species_10601344", "catalyst" ] ], "additional_components": [ "DDB_G0277699", "DDB_G0277699", "Q54PF1", "DDB_G0284601", "Q02720", "DDB_G0276885", "Q54LR6", "DDB_G0286481" ] }, "reaction_10623360": { "compartment": "compartment_17906", "id": "reaction_10623360", "reactome": "R-DDI-8948146", "name": "FUNDC1 is phosphorylated by ULK1 at Ser17", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623342", "species_113592" ], "products": [ "species_10623357", "species_29370" ], "modifiers": [ [ "species_10623349", "catalyst" ] ], "additional_components": [ "DDB_G0277699", "DDB_G0277699", "DDB_G0292390" ] }, "reaction_10623351": { "compartment": "compartment_17906", "id": "reaction_10623351", "reactome": "R-DDI-8948136", "name": "ULK1 Translocates to the mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606654" ], "products": [ "species_10623349" ], "modifiers": [], "additional_components": [ "DDB_G0292390", "DDB_G0292390" ] }, "reaction_10624119": { "compartment": "compartment_21994", "id": "reaction_10624119", "reactome": "R-DDI-8959571", "name": "LC3 binds the autophagosome membrane Atg5-Atg12 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604606", "species_10624115" ], "products": [ "species_10624117" ], "modifiers": [], "additional_components": [ "Q86CR6", "DDB_G0282929", "Q54GT9", "DDB_G0289881", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q75K07", "DDB_G0277699", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q75K07", "DDB_G0277699", "Q86CR6", "DDB_G0282929", "Q54GT9", "DDB_G0289881" ] }, "reaction_10624121": { "compartment": "compartment_70101", "id": "reaction_10624121", "reactome": "R-DDI-8959573", "name": "Phosphorylated FUNDC1 links damaged mitochondria to LC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623357", "species_10624113" ], "products": [ "species_10624115" ], "modifiers": [], "additional_components": [ "DDB_G0277699", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q75K07", "DDB_G0277699" ] }, "reaction_10627184": { "compartment": "compartment_17947", "id": "reaction_10627184", "reactome": "R-DDI-9664880", "name": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627180", "species_10607651" ], "products": [ "species_10627182" ], "modifiers": [], "additional_components": [ "Q54Q21", "DDB_G0284133", "Q55CE3", "DDB_G0270098", "Q54MD1", "DDB_G0286033", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q54Q21", "DDB_G0284133", "Q55CE3", "DDB_G0270098", "Q54MD1", "DDB_G0286033" ] }, "reaction_10627166": { "compartment": "compartment_17947", "id": "reaction_10627166", "reactome": "R-DDI-9664867", "name": "NBR1 binds MAP1LC3B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627162", "species_10607651" ], "products": [ "species_10627164" ], "modifiers": [], "additional_components": [ "DDB_G0284133", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q54Q21", "DDB_G0284133" ] }, "reaction_10606829": { "compartment": "compartment_70101", "id": "reaction_10606829", "reactome": "R-DDI-5672011", "name": "p-AMPK:AMP binds the ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606668", "species_10589958" ], "products": [ "species_10606670" ], "modifiers": [], "additional_components": [ "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390" ] }, "reaction_10607596": { "compartment": "compartment_70101", "id": "reaction_10607596", "reactome": "R-DDI-5676229", "name": "WIPIs bind PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693050", "species_10607592" ], "products": [ "species_10607594" ], "modifiers": [], "additional_components": [ "Q54NA2", "DDB_G0285375", "Q54NA2", "DDB_G0285375", "species_1806200" ] }, "reaction_10607732": { "compartment": "compartment_70101", "id": "reaction_10607732", "reactome": "R-DDI-5679205", "name": "ULK1 phosphorylates Beclin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607717" ], "products": [ "species_29370", "species_10606839" ], "modifiers": [ [ "species_10607729", "catalyst" ] ], "additional_components": [ "Q54JI9", "DDB_G0288021", "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "Q54JI9", "DDB_G0288021", "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390" ] }, "reaction_10608055": { "compartment": "compartment_70101", "id": "reaction_10608055", "reactome": "R-DDI-5683593", "name": "ATG7:ATG3:LC3 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607764" ], "products": [ "species_10607673", "species_10607749" ], "modifiers": [], "additional_components": [ "Q86CR9", "DDB_G0271096", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q550A8", "DDB_G0277319", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q550A8", "DDB_G0277319", "Q86CR9", "DDB_G0271096" ] }, "reaction_10607737": { "compartment": "compartment_70101", "id": "reaction_10607737", "reactome": "R-DDI-5679206", "name": "MTMR14, MTMR3 dephosphorylate PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676030" ], "products": [ "species_426639" ], "modifiers": [ [ "species_10607734", "catalyst" ] ], "additional_components": [ "Q54H00", "DDB_G0289807", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258" ] }, "reaction_10607739": { "compartment": "compartment_70101", "id": "reaction_10607739", "reactome": "R-DDI-5679239", "name": "ULK complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607573" ], "products": [ "species_10607729" ], "modifiers": [], "additional_components": [ "Q54J54", "DDB_G0288287", "Q86CS2", "DDB_G0292390", "Q55BY0", "DDB_G0269162", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390" ] }, "reaction_10606842": { "compartment": "compartment_12045", "id": "reaction_10606842", "reactome": "R-DDI-5672012", "name": "Beclin-1 complex phosphorylates PtdIns", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426639" ], "products": [ "species_29370", "species_5676030" ], "modifiers": [ [ "species_10606839", "catalyst" ] ], "additional_components": [ "Q54JI9", "DDB_G0288021", "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627" ] }, "reaction_10607741": { "compartment": "compartment_70101", "id": "reaction_10607741", "reactome": "R-DDI-5679255", "name": "WIPI2 binds ATG12:ATG5:ATG16L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607693", "species_10607691" ], "products": [ "species_10607695" ], "modifiers": [], "additional_components": [ "species_1806205", "Q54NA2", "DDB_G0285375", "O15736", "DDB_G0275323", "Q86CR6", "DDB_G0282929", "Q54GT9", "DDB_G0289881", "O15736", "DDB_G0275323", "Q86CR6", "DDB_G0282929", "Q54GT9", "DDB_G0289881", "species_1806205", "Q54NA2", "DDB_G0285375" ] }, "reaction_10606846": { "compartment": "compartment_17938", "id": "reaction_10606846", "reactome": "R-DDI-5672017", "name": "Rheb in the MTORC1 complex hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584242" ], "products": [ "species_10589976" ], "modifiers": [ [ "species_10584242", "catalyst" ] ], "additional_components": [ "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318" ] }, "reaction_10607747": { "compartment": "compartment_70101", "id": "reaction_10607747", "reactome": "R-DDI-5679266", "name": "Beclin-1 complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607745" ], "products": [ "species_10607717" ], "modifiers": [], "additional_components": [ "Q54JI9", "DDB_G0288021", "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "Q54JI9", "DDB_G0288021", "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627" ] }, "reaction_10606850": { "compartment": "compartment_70101", "id": "reaction_10606850", "reactome": "R-DDI-5672817", "name": "Active MTORC1 binds the ULK1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606668", "species_10584242" ], "products": [ "species_10606817" ], "modifiers": [], "additional_components": [ "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390" ] }, "reaction_10607753": { "compartment": "compartment_70101", "id": "reaction_10607753", "reactome": "R-DDI-5681980", "name": "ATG12 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607684", "species_10607749" ], "products": [ "species_10607751" ], "modifiers": [], "additional_components": [ "DDB_G0282929", "Q86CR9", "DDB_G0271096", "Q86CR9", "DDB_G0271096", "Q86CR6", "DDB_G0282929" ] }, "reaction_10607564": { "compartment": "compartment_74700", "id": "reaction_10607564", "reactome": "R-DDI-5675790", "name": "MTORC1 dissociates from ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607256" ], "products": [ "species_10606822", "species_10584309" ], "modifiers": [], "additional_components": [ "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54J54", "DDB_G0288287", "Q86CS2", "DDB_G0292390", "Q55BY0", "DDB_G0269162", "Q54J54", "DDB_G0288287", "Q86CS2", "DDB_G0292390", "Q55BY0", "DDB_G0269162", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318" ] }, "reaction_10625487": { "compartment": "compartment_70101", "id": "reaction_10625487", "reactome": "R-DDI-9020616", "name": "ATG12 forms a thioester bond with ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607751" ], "products": [ "species_10608021" ], "modifiers": [], "additional_components": [ "Q86CR9", "DDB_G0271096", "Q86CR6", "DDB_G0282929", "Q86CR6", "DDB_G0282929", "Q86CR9", "DDB_G0271096" ] }, "reaction_10608017": { "compartment": "compartment_5683628", "id": "reaction_10608017", "reactome": "R-DDI-5682388", "name": "Autophagosome maturation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607675" ], "products": [ "species_10608008" ], "modifiers": [ [ "species_10608015", "catalyst" ], [ "species_10594491", "catalyst" ] ], "additional_components": [ "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "species_1500581", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "species_1500581", "Q54JI9", "DDB_G0288021", "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "Q54JC5", "DDB_G0288175", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54P63", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q86H98", "DDB_G0275573" ] }, "reaction_10607824": { "compartment": "compartment_70101", "id": "reaction_10607824", "reactome": "R-DDI-5681987", "name": "LC3 is cleaved by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607793" ], "products": [ "species_10607665" ], "modifiers": [ [ "species_10607821", "catalyst" ] ], "additional_components": [ "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q557H7", "DDB_G0273443" ] }, "reaction_10607826": { "compartment": "compartment_70101", "id": "reaction_10607826", "reactome": "R-DDI-5682011", "name": "LC3 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607749", "species_10607665" ], "products": [ "species_10607760" ], "modifiers": [], "additional_components": [ "Q86CR9", "DDB_G0271096", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096" ] }, "reaction_10607698": { "compartment": "compartment_70101", "id": "reaction_10607698", "reactome": "R-DDI-5678490", "name": "ATG16L1 complex transfers LC3 from ATG3 to PE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5681998", "species_10607673" ], "products": [ "species_10607677", "species_10607675" ], "modifiers": [ [ "species_10607695", "catalyst" ] ], "additional_components": [ "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q550A8", "DDB_G0277319", "DDB_G0277319", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "species_1500581", "O15736", "DDB_G0275323", "Q86CR6", "DDB_G0282929", "Q54GT9", "DDB_G0289881", "species_1806205", "Q54NA2", "DDB_G0285375" ] }, "reaction_10608023": { "compartment": "compartment_70101", "id": "reaction_10608023", "reactome": "R-DDI-5682896", "name": "LC3:ATG7 dimer binds ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607677", "species_10607760" ], "products": [ "species_10607762" ], "modifiers": [], "additional_components": [ "DDB_G0277319", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096", "Q550A8", "DDB_G0277319" ] }, "reaction_10607767": { "compartment": "compartment_70101", "id": "reaction_10607767", "reactome": "R-DDI-5681981", "name": "ATG3 transfers LC3 from ATG7 to ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607762" ], "products": [ "species_10607764" ], "modifiers": [ [ "species_10607762", "catalyst" ] ], "additional_components": [ "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096", "Q550A8", "DDB_G0277319", "Q86CR9", "DDB_G0271096", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q550A8", "DDB_G0277319", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096", "Q550A8", "DDB_G0277319" ] }, "reaction_10607576": { "compartment": "compartment_70101", "id": "reaction_10607576", "reactome": "R-DDI-5675868", "name": "ULK1 phosphorylates ATG13 and RB1CC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606812", "species_113592" ], "products": [ "species_29370", "species_10607573" ], "modifiers": [ [ "species_10606812", "catalyst" ] ], "additional_components": [ "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54J54", "DDB_G0288287", "Q86CS2", "DDB_G0292390", "Q55BY0", "DDB_G0269162", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390" ] }, "reaction_10607258": { "compartment": "compartment_70101", "id": "reaction_10607258", "reactome": "R-DDI-5673768", "name": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10606824" ], "products": [ "species_29370", "species_10607256" ], "modifiers": [ [ "species_10589958", "catalyst" ] ], "additional_components": [ "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54J54", "DDB_G0288287", "Q86CS2", "DDB_G0292390", "Q55BY0", "DDB_G0269162", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54J54", "DDB_G0288287", "Q86CS2", "DDB_G0292390", "Q55BY0", "DDB_G0269162", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643" ] }, "reaction_10608090": { "compartment": "compartment_70101", "id": "reaction_10608090", "reactome": "R-DDI-5683925", "name": "ULK1 is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606822" ], "products": [ "species_10606668", "species_29372" ], "modifiers": [], "additional_components": [ "Q54J54", "DDB_G0288287", "Q86CS2", "DDB_G0292390", "Q55BY0", "DDB_G0269162", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390" ] }, "reaction_10606684": { "compartment": "compartment_70101", "id": "reaction_10606684", "reactome": "R-DDI-5665868", "name": "AMPK (complex) phosphorylates ULK1 (complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606670", "species_113592" ], "products": [ "species_29370", "species_10606681" ], "modifiers": [ [ "species_10606670", "catalyst" ] ], "additional_components": [ "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54J54", "DDB_G0288287", "Q86CS2", "DDB_G0292390", "Q55BY0", "DDB_G0269162", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390" ] }, "reaction_10606815": { "compartment": "compartment_70101", "id": "reaction_10606815", "reactome": "R-DDI-5672008", "name": "Thr-180 of ULK1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10606681" ], "products": [ "species_10606812", "species_29370" ], "modifiers": [ [ "species_10606681", "catalyst" ] ], "additional_components": [ "Q54J54", "DDB_G0288287", "Q86CS2", "DDB_G0292390", "Q55BY0", "DDB_G0269162", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54J54", "DDB_G0288287", "Q86CS2", "DDB_G0292390", "Q55BY0", "DDB_G0269162", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643" ] }, "reaction_10607966": { "compartment": "compartment_70101", "id": "reaction_10607966", "reactome": "R-DDI-5682377", "name": "LC3 de-lipidation by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607675" ], "products": [ "species_5681998", "species_10607665" ], "modifiers": [ [ "species_10607821", "catalyst" ] ], "additional_components": [ "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "species_1500581", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q557H7", "DDB_G0273443" ] }, "reaction_10611248": { "compartment": "compartment_70101", "id": "reaction_10611248", "reactome": "R-DDI-5691512", "name": "APEH hydrolyses NAc-Ser-protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5691496", "species_29356" ], "products": [ "species_6785226", "species_5691517" ], "modifiers": [ [ "species_10611245", "catalyst" ] ], "additional_components": [ "species_5691517", "species_6785219", "DDB_G0267742" ] }, "reaction_10616060": { "compartment": "compartment_70101", "id": "reaction_10616060", "reactome": "R-DDI-6800138", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616038", "species_71284" ], "products": [ "species_10616045", "species_71285" ], "modifiers": [ [ "species_10616057", "catalyst" ] ], "additional_components": [ "Q7YZN9", "DDB_G0277919", "species_29438", "Q9BMX0", "DDB_G0288613", "Q7YZN9", "DDB_G0277919", "species_29438", "Q9BMX0", "DDB_G0288613", "Q54DT3", "DDB_G0292048", "Q54N57", "DDB_G0285489" ] }, "reaction_10601939": { "compartment": "compartment_13231", "id": "reaction_10601939", "reactome": "R-DDI-3000449", "name": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10601921" ], "products": [ "species_10601725", "species_10601936" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54N16", "DDB_G0285563", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54N16", "DDB_G0285563", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10626247": { "compartment": "compartment_1598585", "id": "reaction_10626247", "reactome": "R-DDI-9624845", "name": "RCC1 stimulates GDP to GTP exchange on RAN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10587842" ], "products": [ "species_10626239", "species_29420" ], "modifiers": [ [ "species_10626244", "catalyst" ] ], "additional_components": [ "P33519", "DDB_G0291235", "species_29420", "P33519", "DDB_G0291235", "species_29438", "DDB_G0270246" ] }, "reaction_10626251": { "compartment": "compartment_70101", "id": "reaction_10626251", "reactome": "R-DDI-9624876", "name": "RAN:GTP recruits nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9624879", "species_10626239" ], "products": [ "species_10626249" ], "modifiers": [], "additional_components": [ "P33519", "DDB_G0291235", "species_29438", "P33519", "DDB_G0291235", "species_29438" ] }, "reaction_10626254": { "compartment": "compartment_70101", "id": "reaction_10626254", "reactome": "R-DDI-9624893", "name": "RAN stimulates fusion of nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10626249" ], "products": [ "species_29372", "species_9624890", "species_10587842" ], "modifiers": [ [ "species_10601936", "catalyst" ] ], "additional_components": [ "P33519", "DDB_G0291235", "species_29438", "P33519", "DDB_G0291235", "species_29420", "Q54N16", "DDB_G0285563", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10627210": { "compartment": "compartment_13231", "id": "reaction_10627210", "reactome": "R-DDI-9668395", "name": "CHMP7 binds CC2D1B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627194", "species_10627200" ], "products": [ "species_10627202" ], "modifiers": [], "additional_components": [ "DDB_G0283793", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54P63", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54P63", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54QK5", "DDB_G0283793" ] }, "reaction_10627208": { "compartment": "compartment_70101", "id": "reaction_10627208", "reactome": "R-DDI-9668389", "name": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594774", "species_10627204" ], "products": [ "species_10627206" ], "modifiers": [], "additional_components": [ "DDB_G0284347", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54P63", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54QK5", "DDB_G0283793", "Q54KQ7", "DDB_G0287165", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54P63", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54QK5", "DDB_G0283793", "Q54KQ7", "DDB_G0287165", "Q54PT2", "DDB_G0284347" ] }, "reaction_10627215": { "compartment": "compartment_70101", "id": "reaction_10627215", "reactome": "R-DDI-9668419", "name": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10589898", "species_113592" ], "products": [ "species_29372", "species_29370", "species_10589894" ], "modifiers": [ [ "species_10627204", "catalyst" ] ], "additional_components": [ "species_29438", "species_29420", "species_29438", "species_29420", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54P63", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54QK5", "DDB_G0283793", "Q54KQ7", "DDB_G0287165" ] }, "reaction_10627212": { "compartment": "compartment_70101", "id": "reaction_10627212", "reactome": "R-DDI-9668405", "name": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627189", "species_10627202" ], "products": [ "species_10627204" ], "modifiers": [], "additional_components": [ "DDB_G0287165", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54P63", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54QK5", "DDB_G0283793", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54P63", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54QK5", "DDB_G0283793", "Q54KQ7", "DDB_G0287165" ] }, "reaction_10606306": { "compartment": "compartment_70101", "id": "reaction_10606306", "reactome": "R-DDI-5652172", "name": "AKR1B1 reduces Glc to D-sorbitol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_70113" ], "products": [ "species_29366", "species_5652213" ], "modifiers": [ [ "species_10586772", "catalyst" ] ], "additional_components": [ "Q55FL3", "DDB_G0268058", "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562" ] }, "reaction_10577683": { "compartment": "compartment_70101", "id": "reaction_10577683", "reactome": "R-DDI-70333", "name": "KHK dimer phosphorylates Fru to Fru 1-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29532", "species_113592" ], "products": [ "species_29370", "species_31221" ], "modifiers": [ [ "species_10577680", "catalyst" ], [ "species_29804", "catalyst" ], [ "species_29370", "inhibitor" ] ], "additional_components": [ "Q54D80", "DDB_G0292440" ] }, "reaction_10577703": { "compartment": "compartment_70101", "id": "reaction_10577703", "reactome": "R-DDI-70349", "name": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30393", "species_113592" ], "products": [ "species_29578", "species_29370" ], "modifiers": [ [ "species_10577700", "catalyst" ] ], "additional_components": [ "Q55EE0", "DDB_G0269274", "species_29926" ] }, "reaction_10577693": { "compartment": "compartment_70101", "id": "reaction_10577693", "reactome": "R-DDI-70342", "name": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31221" ], "products": [ "species_30393", "species_75970" ], "modifiers": [ [ "species_10577690", "catalyst" ] ], "additional_components": [ "Q86A67", "DDB_G0274375" ] }, "reaction_10617821": { "compartment": "compartment_70101", "id": "reaction_10617821", "reactome": "R-DDI-6813749", "name": "ALDH1A1 oxidises GA to DGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30393", "species_29360" ], "products": [ "species_6799497", "species_70106", "species_73473" ], "modifiers": [ [ "species_10578688", "catalyst" ] ], "additional_components": [ "Q54IU0", "DDB_G0288521" ] }, "reaction_10605267": { "compartment": "compartment_7660", "id": "reaction_10605267", "reactome": "R-DDI-5358510", "name": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605263", "species_10577431", "species_10605249" ], "products": [ "species_10605265" ], "modifiers": [], "additional_components": [ "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_113592", "Q54K47", "DDB_G0287607", "Q54KD8", "DDB_G0287393", "Q54QA0", "DDB_G0283981", "Q54KD8", "DDB_G0287393", "Q54QA0", "DDB_G0283981", "Q54K47", "DDB_G0287607", "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_113592" ] }, "reaction_10605283": { "compartment": "compartment_7660", "id": "reaction_10605283", "reactome": "R-DDI-5358518", "name": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605265" ], "products": [ "species_10605280" ], "modifiers": [ [ "species_10605265", "catalyst" ] ], "additional_components": [ "Q54KD8", "DDB_G0287393", "Q54QA0", "DDB_G0283981", "Q54K47", "DDB_G0287607", "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_113592", "Q54KD8", "DDB_G0287393", "Q54QA0", "DDB_G0283981", "Q54K47", "DDB_G0287607", "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_113592", "Q54KD8", "DDB_G0287393", "Q54QA0", "DDB_G0283981", "Q54K47", "DDB_G0287607", "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_113592" ] }, "reaction_10605300": { "compartment": "compartment_7660", "id": "reaction_10605300", "reactome": "R-DDI-5358597", "name": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605296", "species_10605280" ], "products": [ "species_10605298" ], "modifiers": [], "additional_components": [ "DDB_G0291570", "Q54KD8", "DDB_G0287393", "Q54QA0", "DDB_G0283981", "Q54K47", "DDB_G0287607", "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_113592", "Q54KD8", "DDB_G0287393", "Q54QA0", "DDB_G0283981", "Q54ED2", "DDB_G0291570", "Q54K47", "DDB_G0287607", "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_113592" ] }, "reaction_10605302": { "compartment": "compartment_7660", "id": "reaction_10605302", "reactome": "R-DDI-5358912", "name": "MSH2:MSH6 exchanges ADP for ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10605287" ], "products": [ "species_113582", "species_10605263" ], "modifiers": [], "additional_components": [ "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_29370", "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_113592" ] }, "reaction_10605289": { "compartment": "compartment_7660", "id": "reaction_10605289", "reactome": "R-DDI-5358525", "name": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605285", "species_5358514" ], "products": [ "species_10605287" ], "modifiers": [], "additional_components": [ "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_29370", "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_29370" ] }, "reaction_10605291": { "compartment": "compartment_7660", "id": "reaction_10605291", "reactome": "R-DDI-5358592", "name": "DNA ligase I ligates single stranded nick in double stranded DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_5358610" ], "products": [ "species_109966", "species_164121", "species_113541" ], "modifiers": [ [ "species_10577488", "catalyst" ] ], "additional_components": [ "DDB_G0274493" ] }, "reaction_10605389": { "compartment": "compartment_7660", "id": "reaction_10605389", "reactome": "R-DDI-5444516", "name": "Formation of MSH2:MSH6 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113582", "species_10605259", "species_10605254" ], "products": [ "species_10605285" ], "modifiers": [], "additional_components": [ "DDB_G0268614", "DDB_G0275809", "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_29370" ] }, "reaction_10605391": { "compartment": "compartment_7660", "id": "reaction_10605391", "reactome": "R-DDI-5444523", "name": "Formation of MSH1:PMS2 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605247", "species_10605242" ], "products": [ "species_10605249" ], "modifiers": [], "additional_components": [ "DDB_G0283981", "DDB_G0287393", "Q54KD8", "DDB_G0287393", "Q54QA0", "DDB_G0283981" ] }, "reaction_10605387": { "compartment": "compartment_7660", "id": "reaction_10605387", "reactome": "R-DDI-5444511", "name": "Formation of MSH2:MSH3 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113582", "species_10605272", "species_10605254" ], "products": [ "species_10605274" ], "modifiers": [], "additional_components": [ "DDB_G0281683", "DDB_G0275809", "Q553L4", "DDB_G0275809", "Q1ZXH0", "DDB_G0281683", "species_29370" ] }, "reaction_10605278": { "compartment": "compartment_7660", "id": "reaction_10605278", "reactome": "R-DDI-5358513", "name": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5358527", "species_10605274" ], "products": [ "species_10605276" ], "modifiers": [], "additional_components": [ "Q553L4", "DDB_G0275809", "Q1ZXH0", "DDB_G0281683", "species_29370", "Q553L4", "DDB_G0275809", "Q1ZXH0", "DDB_G0281683", "species_29370" ] }, "reaction_10582371": { "compartment": "compartment_7660", "id": "reaction_10582371", "reactome": "R-DDI-77071", "name": "Phosphorylation (Ser5) of RNA pol II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10582368" ], "products": [ "species_113582", "species_10582364" ], "modifiers": [ [ "species_10582368", "catalyst" ] ], "additional_components": [ "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729" ] }, "reaction_10582386": { "compartment": "compartment_7660", "id": "reaction_10582386", "reactome": "R-DDI-77073", "name": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582382", "species_10582376", "species_10582360" ], "products": [ "species_10582384" ], "modifiers": [], "additional_components": [ "DDB_G0287661", "DDB_G0278479", "Q54HV6", "DDB_G0289199", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661" ] }, "reaction_10582362": { "compartment": "compartment_7660", "id": "reaction_10582362", "reactome": "R-DDI-77068", "name": "Activation of GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582360" ], "products": [ "species_10582360" ], "modifiers": [], "additional_components": [ "Q54HV6", "DDB_G0289199", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10583326": { "compartment": "compartment_7660", "id": "reaction_10583326", "reactome": "R-DDI-113430", "name": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582368" ], "products": [ "species_10582368" ], "modifiers": [], "additional_components": [ "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729" ] }, "reaction_10582366": { "compartment": "compartment_7660", "id": "reaction_10582366", "reactome": "R-DDI-77069", "name": "RNA Polymerase II CTD (phosphorylated) binds to CE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582364", "species_10582358" ], "products": [ "species_10582360" ], "modifiers": [], "additional_components": [ "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "DDB_G0289199", "Q54HV6", "DDB_G0289199", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10577491": { "compartment": "compartment_7660", "id": "reaction_10577491", "reactome": "R-DDI-69173", "name": "Joining of adjacent Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_68452" ], "products": [ "species_69172" ], "modifiers": [ [ "species_10577488", "catalyst" ] ], "additional_components": [ "DDB_G0274493" ] }, "reaction_10577467": { "compartment": "compartment_7660", "id": "reaction_10577467", "reactome": "R-DDI-69116", "name": "Formation of Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577460" ], "products": [ "species_10577464" ], "modifiers": [ [ "species_10577458", "catalyst" ] ], "additional_components": [ "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609" ] }, "reaction_10577483": { "compartment": "compartment_7660", "id": "reaction_10577483", "reactome": "R-DDI-69152", "name": "Removal of remaining Flap", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577473" ], "products": [ "species_10577475" ], "modifiers": [ [ "species_10577480", "catalyst" ] ], "additional_components": [ "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "DDB_G0284987" ] }, "reaction_10577471": { "compartment": "compartment_7660", "id": "reaction_10577471", "reactome": "R-DDI-69127", "name": "Formation of the Flap Intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577464" ], "products": [ "species_10577469" ], "modifiers": [], "additional_components": [ "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731" ] }, "reaction_10595408": { "compartment": "compartment_20699", "id": "reaction_10595408", "reactome": "R-DDI-964825", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964831" ], "products": [ "species_964752", "species_964740" ], "modifiers": [ [ "species_10595395", "catalyst" ] ], "additional_components": [ "CHEBI:60629", "CHEBI:60628", "CHEBI:60627", "Q54CH4", "DDB_G0292918", "Q54PP9", "DDB_G0292918", "Q54PQ0", "DDB_G0292918", "Q54PQ1", "DDB_G0292918", "Q55EU0", "DDB_G0292918" ] }, "reaction_10595410": { "compartment": "compartment_20699", "id": "reaction_10595410", "reactome": "R-DDI-964830", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964828" ], "products": [ "species_964752", "species_964740" ], "modifiers": [ [ "species_10595395", "catalyst" ] ], "additional_components": [ "Q54CH4", "DDB_G0292918", "Q54PP9", "DDB_G0292918", "Q54PQ0", "DDB_G0292918", "Q54PQ1", "DDB_G0292918", "Q55EU0", "DDB_G0292918" ] }, "reaction_10595398": { "compartment": "compartment_20699", "id": "reaction_10595398", "reactome": "R-DDI-964737", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_915149" ], "products": [ "species_964752", "species_964740" ], "modifiers": [ [ "species_10595395", "catalyst" ] ], "additional_components": [ "Q54CH4", "DDB_G0292918", "Q54PP9", "DDB_G0292918", "Q54PQ0", "DDB_G0292918", "Q54PQ1", "DDB_G0292918", "Q55EU0", "DDB_G0292918" ] }, "reaction_10595406": { "compartment": "compartment_20699", "id": "reaction_10595406", "reactome": "R-DDI-964768", "name": "Addition of GlcNAc to the glycan on the A arm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_964740" ], "products": [ "species_964837", "species_205687" ], "modifiers": [ [ "species_10595403", "catalyst" ] ], "additional_components": [ "DDB_G0288463" ] }, "reaction_10593280": { "compartment": "compartment_70101", "id": "reaction_10593280", "reactome": "R-DDI-450466", "name": "AUF1:mRNA complex is destroyed", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593278" ], "products": [], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q86I71", "DDB_G0279695", "Q54WE9", "DDB_G0279695", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10593258": { "compartment": "compartment_70101", "id": "reaction_10593258", "reactome": "R-DDI-450434", "name": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_450444", "species_10593252" ], "products": [ "species_10593256" ], "modifiers": [], "additional_components": [ "Q54WE9", "DDB_G0279695", "Q86I71", "DDB_G0279695", "Q54WE9", "DDB_G0279695", "Q86I71", "DDB_G0279695" ] }, "reaction_10591793": { "compartment": "compartment_114584", "id": "reaction_10591793", "reactome": "R-DDI-429157", "name": "ABCC4 accumulation of dense granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370" ], "products": [ "species_114565" ], "modifiers": [ [ "species_10591790", "catalyst" ] ], "additional_components": [ "DDB_G0284867" ] }, "reaction_10589393": { "compartment": "compartment_161320", "id": "reaction_10589393", "reactome": "R-DDI-351341", "name": "Exocytosis of Proactivator polypeptide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589385" ], "products": [ "species_10589391" ], "modifiers": [], "additional_components": [ "Q54WE0", "DDB_G0279713", "Q54G42", "DDB_G0290417", "Q54G42", "DDB_G0290417", "Q54WE0", "DDB_G0279713" ] }, "reaction_10593603": { "compartment": "compartment_876", "id": "reaction_10593603", "reactome": "R-DDI-481010", "name": "Surface deployment of platelet dense granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593573" ], "products": [ "species_10593601" ], "modifiers": [], "additional_components": [ "Q54P07", "DDB_G0285051", "Q8T193", "DDB_G0294577", "Q54S62", "DDB_G0294577", "Q1ZXG2", "DDB_G0294577", "Q54S63", "DDB_G0282651", "Q1ZXN9", "DDB_G0294577", "Q55EF0", "DDB_G0269262", "Q54E92", "DDB_G0291738", "Q55EG6", "DDB_G0268910", "Q54FL2", "DDB_G0290783", "Q86JC8", "DDB_G0275955", "Q54G48", "DDB_G0290407", "Q86JP5", "DDB_G0271980", "Q1ZXG2", "DDB_G0294577", "Q1ZXN9", "DDB_G0294577", "Q54E92", "DDB_G0291738", "Q54FL2", "DDB_G0290783", "Q54G48", "DDB_G0290407", "Q54P07", "DDB_G0285051", "Q54S62", "DDB_G0294577", "Q54S63", "DDB_G0282651", "Q55EF0", "DDB_G0269262", "Q55EG6", "DDB_G0268910", "Q86JC8", "DDB_G0275955", "Q86JP5", "DDB_G0271980", "Q8T193", "DDB_G0294577" ] }, "reaction_10593475": { "compartment": "compartment_876", "id": "reaction_10593475", "reactome": "R-DDI-481007", "name": "Exocytosis of platelet alpha granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593433" ], "products": [ "species_10593473" ], "modifiers": [], "additional_components": [ "Q55ET7", "DDB_G0268758", "Q55DM8", "DDB_G0269600", "Q55FE2", "DDB_G0268156", "Q86A67", "DDB_G0274375", "Q553C3", "DDB_G0275765", "Q54KR6", "DDB_G0287201", "Q8T2H0", "DDB_G0272190", "P05095", "DDB_G0268632", "Q54V78", "DDB_G0280565", "Q54PA3", "DDB_G0284679", "Q54D77", "DDB_G0292538", "Q86A67", "DDB_G0274375", "Q54KR6", "DDB_G0287201", "Q54D77", "DDB_G0292538", "Q55ET7", "DDB_G0268758", "Q8T2H0", "DDB_G0272190", "Q54PA3", "DDB_G0284679", "P05095", "DDB_G0268632", "Q54V78", "DDB_G0280565", "Q55FE2", "DDB_G0268156", "Q55DM8", "DDB_G0269600", "Q553C3", "DDB_G0275765" ] }, "reaction_10593506": { "compartment": "compartment_876", "id": "reaction_10593506", "reactome": "R-DDI-481009", "name": "Exocytosis of platelet dense granule content", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593494" ], "products": [ "species_10593504" ], "modifiers": [], "additional_components": [ "species_29438", "species_29372", "species_29370", "Q54F16", "DDB_G0291191", "P04988", "DDB_G0290957", "species_29926", "species_74112", "Q54D84", "DDB_G0292436", "species_113592", "species_209914", "species_29420", "species_113541", "species_74112", "species_29438", "species_29370", "species_113541", "species_29926", "species_209914", "species_113592", "species_29372", "P04988", "DDB_G0290957", "Q54F16", "DDB_G0291191", "species_29420", "Q54D84", "DDB_G0292436" ] }, "reaction_10593830": { "compartment": "compartment_70101", "id": "reaction_10593830", "reactome": "R-DDI-482772", "name": "Release of platelet cytosolic components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593734" ], "products": [ "species_10593828" ], "modifiers": [], "additional_components": [ "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "Q54TA6", "DDB_G0281889", "P32255", "DDB_G0287689", "Q55GQ5", "DDB_G0267420", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993", "Q54RX2", "DDB_G0282859", "Q54W22", "DDB_G0282287", "Q551W8", "DDB_G0282287", "Q54ST8", "DDB_G0282287", "Q54QM3", "DDB_G0283859", "Q54QC8", "DDB_G0283937", "Q54ZW8", "DDB_G0277343", "Q556T3", "DDB_G0273107", "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54L54", "DDB_G0286893", "Q54JD4", "DDB_G0288133", "P54686", "DDB_G0278733", "Q54K81", "DDB_G0287505", "P24639", "DDB_G0269160", "Q54PW0", "DDB_G0284261", "P54686", "DDB_G0278733", "P24639", "DDB_G0269160", "Q54PW0", "DDB_G0284261", "Q54RX2", "DDB_G0282859", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993", "Q55GQ5", "DDB_G0267420", "Q54QM3", "DDB_G0283859", "P32255", "DDB_G0287689", "Q54TA6", "DDB_G0281889", "Q54L54", "DDB_G0286893", "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54JD4", "DDB_G0288133", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "O00897", "DDB_G0269104", "Q54K81", "DDB_G0287505", "Q54QC8", "DDB_G0283937", "Q54ZW8", "DDB_G0277343", "Q54ST8", "DDB_G0282287", "Q54W22", "DDB_G0282287", "Q551W8", "DDB_G0282287", "Q556T3", "DDB_G0273107" ] }, "reaction_10593644": { "compartment": "compartment_876", "id": "reaction_10593644", "reactome": "R-DDI-481044", "name": "Surface deployment of platelet alpha granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593628" ], "products": [ "species_10593642" ], "modifiers": [], "additional_components": [ "Q55CV7", "DDB_G0270986", "Q55CW7", "DDB_G0269872", "Q55CV4", "DDB_G0270682", "Q55CV5", "DDB_G0269110", "Q55FQ9", "DDB_G0267440", "Q9BKJ9", "DDB_G0287035", "Q9XYS8", "DDB_G0267406", "Q54RR0", "DDB_G0282977", "Q9XYS8", "DDB_G0267406", "Q55FQ9", "DDB_G0267440", "Q9BKJ9", "DDB_G0287035", "Q55CV5", "DDB_G0269110", "Q55CV7", "DDB_G0270986", "Q55CW7", "DDB_G0269872", "Q55CV4", "DDB_G0270682", "Q54RR0", "DDB_G0282977" ] }, "reaction_10622966": { "compartment": "compartment_70101", "id": "reaction_10622966", "reactome": "R-DDI-8936849", "name": "AHR:2xHSP90:AIP:PTGES3 binds TCDD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8936852", "species_10622962" ], "products": [ "species_10622964" ], "modifiers": [], "additional_components": [ "Q54R57", "DDB_G0283399", "Q55FM3", "DDB_G0268042", "P54651", "DDB_G0267400", "Q54FE2", "DDB_G0290947", "Q54R57", "DDB_G0283399", "Q55FM3", "DDB_G0268042", "P54651", "DDB_G0267400", "Q54FE2", "DDB_G0290947", "species_8936852" ] }, "reaction_10622996": { "compartment": "compartment_70101", "id": "reaction_10622996", "reactome": "R-DDI-8937169", "name": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622964" ], "products": [ "species_10622994" ], "modifiers": [], "additional_components": [ "Q54R57", "DDB_G0283399", "Q55FM3", "DDB_G0268042", "P54651", "DDB_G0267400", "Q54FE2", "DDB_G0290947", "species_8936852", "P54651", "DDB_G0267400", "Q54R57", "DDB_G0283399", "Q54FE2", "DDB_G0290947", "Q55FM3", "DDB_G0268042", "species_8936852" ] }, "reaction_10623002": { "compartment": "compartment_7660", "id": "reaction_10623002", "reactome": "R-DDI-8937191", "name": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622994" ], "products": [ "species_10623000", "species_10622998" ], "modifiers": [], "additional_components": [ "P54651", "DDB_G0267400", "Q54R57", "DDB_G0283399", "Q54FE2", "DDB_G0290947", "Q55FM3", "DDB_G0268042", "species_8936852", "P54651", "DDB_G0267400", "Q54R57", "DDB_G0283399", "Q55FM3", "DDB_G0268042", "species_8936852", "Q54FE2", "DDB_G0290947" ] }, "reaction_10616539": { "compartment": "compartment_7660", "id": "reaction_10616539", "reactome": "R-DDI-6803523", "name": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10579116", "species_10579164", "species_10616535" ], "products": [ "species_10616537" ], "modifiers": [], "additional_components": [ "DDB_G0280393", "DDB_G0284321", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54PW8", "DDB_G0284321", "Q54VI2", "DDB_G0280393" ] }, "reaction_10582577": { "compartment": "compartment_876", "id": "reaction_10582577", "reactome": "R-DDI-109700", "name": "AKT2 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10582573" ], "products": [ "species_10582559", "species_10582575" ], "modifiers": [], "additional_components": [ "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "Q556W3", "DDB_G0273293", "DDB_G0273293", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_179838" ] }, "reaction_10582601": { "compartment": "compartment_70101", "id": "reaction_10582601", "reactome": "R-DDI-109702", "name": "PDPK1 phosphorylates AKT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582575", "species_113592" ], "products": [ "species_29370", "species_10582598" ], "modifiers": [ [ "species_10582584", "catalyst" ] ], "additional_components": [ "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_179838", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_179838", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10582586": { "compartment": "compartment_876", "id": "reaction_10582586", "reactome": "R-DDI-109701", "name": "PDPK1 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10582582" ], "products": [ "species_10582584" ], "modifiers": [], "additional_components": [ "DDB_G0281471", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10583853": { "compartment": "compartment_70101", "id": "reaction_10583853", "reactome": "R-DDI-162425", "name": "p-S295-PDE3B hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10583850", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121" ] }, "reaction_10605020": { "compartment": "compartment_171062", "id": "reaction_10605020", "reactome": "R-DDI-5252133", "name": "ATP6AP1 binds V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581337", "species_10581332" ], "products": [ "species_10581339" ], "modifiers": [], "additional_components": [ "DDB_G0273483", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q55AH5", "DDB_G0271882", "Q86A77", "DDB_G0274331", "O00780", "DDB_G0275701", "Q54Z13", "DDB_G0277971", "Q76NU1", "DDB_G0277401", "P54648", "DDB_G0284473", "P54641", "DDB_G0273071", "Q86AS7", "DDB_G0274141", "Q54E04", "DDB_G0291858", "P54642", "DDB_G0274381", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q55AH5", "DDB_G0271882", "Q86A77", "DDB_G0274331", "O00780", "DDB_G0275701", "Q54Z13", "DDB_G0277971", "Q76NU1", "DDB_G0277401", "P54648", "DDB_G0284473", "P54641", "DDB_G0273071", "Q86AS7", "DDB_G0274141", "Q54E04", "DDB_G0291858", "P54642", "DDB_G0274381", "Q557I5", "DDB_G0273483" ] }, "reaction_10581342": { "compartment": "compartment_17940", "id": "reaction_10581342", "reactome": "R-DDI-74723", "name": "Endosome acidification", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106" ], "products": [ "species_74722" ], "modifiers": [ [ "species_10581339", "catalyst" ] ], "additional_components": [ "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q55AH5", "DDB_G0271882", "Q86A77", "DDB_G0274331", "O00780", "DDB_G0275701", "Q54Z13", "DDB_G0277971", "Q76NU1", "DDB_G0277401", "P54648", "DDB_G0284473", "P54641", "DDB_G0273071", "Q86AS7", "DDB_G0274141", "Q54E04", "DDB_G0291858", "P54642", "DDB_G0274381", "Q557I5", "DDB_G0273483" ] }, "reaction_10586962": { "compartment": "compartment_70101", "id": "reaction_10586962", "reactome": "R-DDI-198270", "name": "PDPK1 phosphorylates AKT at T308", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10586941", "species_113592" ], "products": [ "species_10586959", "species_29370", "species_10582584" ], "modifiers": [ [ "species_10586941", "catalyst" ] ], "additional_components": [ "Q54TW2", "DDB_G0281471", "species_179838", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "Q54TW2", "DDB_G0281471", "species_179838", "Q54TW2", "DDB_G0281471", "species_179838", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795" ] }, "reaction_10587030": { "compartment": "compartment_70101", "id": "reaction_10587030", "reactome": "R-DDI-198640", "name": "TORC2 (mTOR) phosphorylates AKT at S473", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10587009" ], "products": [ "species_10586939", "species_29370" ], "modifiers": [ [ "species_10587023", "catalyst" ], [ "species_10587028", "inhibitor" ] ], "additional_components": [ "species_179838", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_179838", "Q54D08", "DDB_G0292592", "O77203", "DDB_G0277399", "Q9Y0C9", "DDB_G0284611", "Q86C65", "DDB_G0281569", "species_179838", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "Q556W3", "DDB_G0273293" ] }, "reaction_10600856": { "compartment": "compartment_70101", "id": "reaction_10600856", "reactome": "R-DDI-2316429", "name": "PIP3 recruits PDPK1 to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10587607" ], "products": [ "species_10582584" ], "modifiers": [], "additional_components": [ "DDB_G0281471", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10600858": { "compartment": "compartment_876", "id": "reaction_10600858", "reactome": "R-DDI-2317314", "name": "AKT binds PDPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10586939", "species_10582584" ], "products": [ "species_10586941" ], "modifiers": [], "additional_components": [ "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_179838", "Q54TW2", "DDB_G0281471", "species_179838", "Q54TW2", "DDB_G0281471", "species_179838", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795" ] }, "reaction_10604751": { "compartment": "compartment_70101", "id": "reaction_10604751", "reactome": "R-DDI-5218845", "name": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604748", "species_113592" ], "products": [ "species_5218688", "species_29370", "species_10585144", "species_10585895" ], "modifiers": [ [ "species_10604744", "catalyst" ] ], "additional_components": [ "Q54Q13", "DDB_G0284177", "species_428662", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "DDB_G0284177", "DDB_G0284545" ] }, "reaction_10597490": { "compartment": "compartment_70101", "id": "reaction_10597490", "reactome": "R-DDI-1358789", "name": "Self-ubiquitination of RNF41", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10596295" ], "products": [ "species_10597487" ], "modifiers": [ [ "species_10596295", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q559W7", "DDB_G0283193", "Q55CL1", "DDB_G0283193", "Q54RD2", "DDB_G0283193", "Q559W7", "DDB_G0283193", "Q55CL1", "DDB_G0283193", "Q54RD2", "DDB_G0283193", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q559W7", "DDB_G0283193", "Q55CL1", "DDB_G0283193", "Q54RD2", "DDB_G0283193" ] }, "reaction_10599553": { "compartment": "compartment_70101", "id": "reaction_10599553", "reactome": "R-DDI-1855223", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994141" ], "products": [ "species_29370", "species_1629755" ], "modifiers": [ [ "species_10599359", "catalyst" ] ], "additional_components": [ "Q54B75", "DDB_G0293860", "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0293860", "Q55AP4", "DDB_G0293860" ] }, "reaction_10599443": { "compartment": "compartment_70101", "id": "reaction_10599443", "reactome": "R-DDI-1855193", "name": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629736" ], "products": [ "species_29370", "species_1629738" ], "modifiers": [ [ "species_10599359", "catalyst" ] ], "additional_components": [ "Q54B75", "DDB_G0293860", "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0293860", "Q55AP4", "DDB_G0293860" ] }, "reaction_10599522": { "compartment": "compartment_70101", "id": "reaction_10599522", "reactome": "R-DDI-1855219", "name": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994141" ], "products": [ "species_29372", "species_994149" ], "modifiers": [ [ "species_10599364", "catalyst" ] ], "additional_components": [ "species_29926", "Q55D87", "DDB_G0269746" ] }, "reaction_10599362": { "compartment": "compartment_70101", "id": "reaction_10599362", "reactome": "R-DDI-1855158", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_113592" ], "products": [ "species_29370", "species_1629759" ], "modifiers": [ [ "species_10599359", "catalyst" ] ], "additional_components": [ "Q54B75", "DDB_G0293860", "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0293860", "Q55AP4", "DDB_G0293860" ] }, "reaction_10599446": { "compartment": "compartment_70101", "id": "reaction_10599446", "reactome": "R-DDI-1855194", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629740" ], "products": [ "species_1629732", "species_29370" ], "modifiers": [ [ "species_10599359", "catalyst" ] ], "additional_components": [ "Q54B75", "DDB_G0293860", "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0293860", "Q55AP4", "DDB_G0293860" ] }, "reaction_10599432": { "compartment": "compartment_70101", "id": "reaction_10599432", "reactome": "R-DDI-1855179", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994141" ], "products": [ "species_29370", "species_1629770" ], "modifiers": [ [ "species_10599429", "catalyst" ] ], "additional_components": [ "DDB_G0288351" ] }, "reaction_10599370": { "compartment": "compartment_70101", "id": "reaction_10599370", "reactome": "R-DDI-1855162", "name": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994149", "species_113592" ], "products": [ "species_29370", "species_994141" ], "modifiers": [ [ "species_10599364", "catalyst" ] ], "additional_components": [ "species_29926", "Q55D87", "DDB_G0269746" ] }, "reaction_10599562": { "compartment": "compartment_70101", "id": "reaction_10599562", "reactome": "R-DDI-1855227", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629770" ], "products": [ "species_1629765", "species_29370" ], "modifiers": [ [ "species_10599359", "catalyst" ] ], "additional_components": [ "Q54B75", "DDB_G0293860", "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0293860", "Q55AP4", "DDB_G0293860" ] }, "reaction_10597363": { "compartment": "compartment_876", "id": "reaction_10597363", "reactome": "R-DDI-1296039", "name": "Activation of Ca2+ activated Potassium channels with small conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10597360", "catalyst" ] ], "additional_components": [ "Q55CX3", "DDB_G0269864" ] }, "reaction_10597350": { "compartment": "compartment_876", "id": "reaction_10597350", "reactome": "R-DDI-1296035", "name": "Activation of Ca2+ activated Potassium channels with Intermediate conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10597347", "catalyst" ] ], "additional_components": [ "DDB_G0269864" ] }, "reaction_10597483": { "compartment": "compartment_876", "id": "reaction_10597483", "reactome": "R-DDI-1299359", "name": "Activation of TALK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10597480", "catalyst" ] ], "additional_components": [ "Q86K40", "DDB_G0277255", "Q8T268", "DDB_G0277255" ] }, "reaction_10597466": { "compartment": "compartment_876", "id": "reaction_10597466", "reactome": "R-DDI-1299338", "name": "Activation of TRESK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10597463", "catalyst" ] ], "additional_components": [ "Q86K40", "DDB_G0277255", "Q8T268", "DDB_G0277255" ] }, "reaction_10597405": { "compartment": "compartment_876", "id": "reaction_10597405", "reactome": "R-DDI-1299297", "name": "Activation of THIK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10597402", "catalyst" ] ], "additional_components": [ "Q86K40", "DDB_G0277255", "Q8T268", "DDB_G0277255" ] }, "reaction_10597455": { "compartment": "compartment_876", "id": "reaction_10597455", "reactome": "R-DDI-1299318", "name": "Activation of TASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10597452", "catalyst" ] ], "additional_components": [ "Q86K40", "DDB_G0277255", "Q8T268", "DDB_G0277255" ] }, "reaction_10597434": { "compartment": "compartment_876", "id": "reaction_10597434", "reactome": "R-DDI-1299304", "name": "Activation of tandem pore domain in a weak inwardly rectifying K+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10597431", "catalyst" ] ], "additional_components": [ "Q8T268", "DDB_G0277255", "Q86K40", "DDB_G0277255" ] }, "reaction_10590872": { "compartment": "compartment_876", "id": "reaction_10590872", "reactome": "R-DDI-420688", "name": "GABAB heterodimeric receptor binds GABA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589803", "species_352003" ], "products": [ "species_10589805" ], "modifiers": [], "additional_components": [ "Q54F54", "DDB_G0291095", "Q54K09", "DDB_G0287905", "Q54ET0", "DDB_G0291356", "species_916850", "Q54F54", "DDB_G0291095", "Q54K09", "DDB_G0287905", "Q54ET0", "DDB_G0291356" ] }, "reaction_10584963": { "compartment": "compartment_876", "id": "reaction_10584963", "reactome": "R-DDI-170686", "name": "Adenylate cyclase increases the GTPase activity of Gi alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584931" ], "products": [ "species_29372", "species_10584949" ], "modifiers": [ [ "species_10584931", "catalyst" ] ], "additional_components": [ "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545", "species_29420", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29926", "Q03100", "DDB_G0281545", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545" ] }, "reaction_10584951": { "compartment": "compartment_876", "id": "reaction_10584951", "reactome": "R-DDI-170674", "name": "Dissociation of the Gi alpha:G olf complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584949" ], "products": [ "species_10583022", "species_10584933", "species_10584947" ], "modifiers": [], "additional_components": [ "species_29420", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29926", "Q03100", "DDB_G0281545", "species_29926", "Q03100", "DDB_G0281545", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29420", "species_29420", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343" ] }, "reaction_10584938": { "compartment": "compartment_876", "id": "reaction_10584938", "reactome": "R-DDI-170666", "name": "Adenylate cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584931" ], "products": [ "species_29372", "species_10584935" ], "modifiers": [ [ "species_10584931", "catalyst" ] ], "additional_components": [ "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545", "species_29420", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545" ] }, "reaction_10584940": { "compartment": "compartment_876", "id": "reaction_10584940", "reactome": "R-DDI-170671", "name": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584867", "species_10584929" ], "products": [ "species_10584931" ], "modifiers": [], "additional_components": [ "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545" ] }, "reaction_10583667": { "compartment": "compartment_7660", "id": "reaction_10583667", "reactome": "R-DDI-156661", "name": "Formation of Exon Junction Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10579667", "species_10579651" ], "products": [ "species_10579671" ], "modifiers": [], "additional_components": [ "Q54ME8", "DDB_G0286007", "Q55E21", "DDB_G0270866", "Q55BF5", "DDB_G0271312", "Q86JC5", "DDB_G0275957", "Q1ZXF6", "DDB_G0284555", "Q54LY9", "DDB_G0286297", "Q54IV3", "DDB_G0288501", "Q54SA7", "DDB_G0282569", "Q54BG2", "DDB_G0293636", "Q54PP4", "DDB_G0284403", "Q54TL3", "DDB_G0281687", "Q55CI7", "DDB_G0271014", "Q54Q46", "DDB_G0284101", "Q54J05", "DDB_G0288391", "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q553B1", "DDB_G0275443", "Q54NJ4", "DDB_G0285213", "Q55BL6", "DDB_G0270450", "Q86A14", "DDB_G0272676", "Q54B65", "DDB_G0293876", "Q55CK7", "DDB_G0270020", "Q557T0", "DDB_G0273383", "Q7KWK5", "DDB_G0276803", "Q54SG7", "DDB_G0282763", "Q54WZ0", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10579612", "species_10579597", "species_10579592", "species_10579497", "species_10579607", "species_10579602", "species_10579617" ], "products": [ "species_10579055", "species_10579002", "species_10579050", "species_10579478", "species_10579623", "species_10579060", "species_10579301", "species_10578963", "species_10579473" ], "modifiers": [], "additional_components": [ "DDB_G0283901", "DDB_G0269192", "Q54V94", "DDB_G0280529", "Q54XS9", "DDB_G0278769", "Q54LG7", "DDB_G0286645", "Q54WL8", "DDB_G0279559", "Q54N48", "DDB_G0285507", "Q54J73", "DDB_G0288259", "Q55E68", "DDB_G0269370", "Q54ZS8", "DDB_G0277371", "Q55BS1", "DDB_G0270392", "Q55CA3", "DDB_G0270148", "Q54PX4", "DDB_G0284319", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797", "C7G084", "DDB_G0295793", "Q54TS6", "DDB_G0281585", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q8T295", "DDB_G0274229", "Q54ST0", "DDB_G0282243", "Q553S5", "DDB_G0275407", "Q55A15", "DDB_G0272374", "Q54R72", "DDB_G0283359", "Q55AR8", "DDB_G0271788", "Q54TF6", "DDB_G0281779", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q54XH4", "DDB_G0278929", "Q54TQ2", "DDB_G0281621", "Q54WN2", "DDB_G0279535", "Q54K20", "DDB_G0287635", "Q86J17", "DDB_G0274281", "Q8T2A7", "DDB_G0274213", "C7G068", "DDB_G0289595", "Q54HF6", "DDB_G0289499", "Q54KX4", "DDB_G0287053", "Q55EX5", "DDB_G0268716", "Q1ZXD5", "DDB_G0288479", "Q1ZXK3", "DDB_G0277107", "Q552U1", "DDB_G0275719", "Q54ZS5", "DDB_G0277375", "Q54N41", "DDB_G0285521", "Q55A46", "DDB_G0272108", "Q54E37", "DDB_G0291836", "Q54XP4", "DDB_G0278819", "Q54YA5", "DDB_G0278335", "Q55FQ0", "DDB_G0268004", "Q54J05", "DDB_G0288391", "Q55BU3", "DDB_G0270360", "Q55EN0", "DDB_G0269006", "Q54LV5", "DDB_G0286395", "Q54MH4", "DDB_G0285843", "Q54LX5", "DDB_G0286361", "Q54CE0", "DDB_G0293168", "Q1ZXB1", "DDB_G0291966", "Q54PX3", "DDB_G0291966", "Q86IV3", "DDB_G0274361", "Q54HF5", "DDB_G0289501", "Q54Z08", "DDB_G0277977", "Q55EC6", "DDB_G0269300", "P54705", "DDB_G0269188", "Q86A78", "DDB_G0274577", "Q54FZ3", "DDB_G0290649", "Q54NB4", "DDB_G0285363", "Q54NB3", "DDB_G0285363", "Q54WE9", "DDB_G0279695", "Q86I71", "DDB_G0279695", "Q54VI2", "DDB_G0280393", "Q9NI62", "DDB_G0269216", "Q557T0", "DDB_G0273383", "Q7KWK5", "DDB_G0276803", "Q54SG7", "DDB_G0282763", "Q54WZ0", "DDB_G0279311", "Q54CN1", "DDB_G0292846", "P36415", "DDB_G0269144", "Q54WP9", "DDB_G0279507", "Q54CT3", "DDB_G0292778", "Q55BF5", "DDB_G0271312", "Q86JC5", "DDB_G0275957", "Q1ZXF6", "DDB_G0284555", "Q54LY9", "DDB_G0286297", "Q54IV3", "DDB_G0288501", "Q54SA7", "DDB_G0282569", "Q54BG2", "DDB_G0293636", "Q54PP4", "DDB_G0284403", "Q54TL3", "DDB_G0281687", "Q55CI7", "DDB_G0271014", "Q54Q46", "DDB_G0284101", "Q553B1", "DDB_G0275443", "Q54NJ4", "DDB_G0285213", "Q55BL6", "DDB_G0270450", "Q86A14", "DDB_G0272676", "Q54B65", "DDB_G0293876", "Q55CK7", "DDB_G0270020", "Q54YS7", "DDB_G0278105", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54NS6", "DDB_G0285077", "Q54LT3", "DDB_G0286425", "Q55G70", "DDB_G0267796", "Q555Z2", "DDB_G0274797", "Q54PW8", "DDB_G0284321", "DDB_G0289933", "DDB_G0285937", "DDB_G0268358", "DDB_G0279535", "Q54HF6", "DDB_G0289499", "Q54KX4", "DDB_G0287053", "Q55EX5", "DDB_G0268716", "Q1ZXD5", "DDB_G0288479", "Q54TF6", "DDB_G0281779", "Q1ZXK3", "DDB_G0277107", "Q552U1", "DDB_G0275719", "DDB_G0281621", "DDB_G0286361", "Q54LT3", "DDB_G0286425", "Q54NS6", "DDB_G0285077", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55BF5", "DDB_G0271312", "Q86JC5", "DDB_G0275957", "Q1ZXF6", "DDB_G0284555", "Q54LY9", "DDB_G0286297", "Q54IV3", "DDB_G0288501", "Q54SA7", "DDB_G0282569", "Q54BG2", "DDB_G0293636", "Q54PP4", "DDB_G0284403", "Q54TL3", "DDB_G0281687", "Q55CI7", "DDB_G0271014", "Q54Q46", "DDB_G0284101", "Q54J05", "DDB_G0288391", "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q553B1", "DDB_G0275443", "Q54NJ4", "DDB_G0285213", "Q55BL6", "DDB_G0270450", "Q86A14", "DDB_G0272676", "Q54B65", "DDB_G0293876", "Q55CK7", "DDB_G0270020", "Q557T0", "DDB_G0273383", "Q7KWK5", "DDB_G0276803", "Q54SG7", "DDB_G0282763", "Q54WZ0", "DDB_G0279311", "Q54CN1", "DDB_G0292846", "P36415", "DDB_G0269144", "Q54WP9", "DDB_G0279507", "Q54CT3", "DDB_G0292778", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54ZS5", "DDB_G0277375", "Q54N41", "DDB_G0285521", "Q55A46", "DDB_G0272108", "Q54XP4", "DDB_G0278819", "Q8T295", "DDB_G0274229", "Q54ST0", "DDB_G0282243", "Q553S5", "DDB_G0275407", "Q55A15", "DDB_G0272374", "Q54R72", "DDB_G0283359", "Q55AR8", "DDB_G0271788", "Q54TF6", "DDB_G0281779", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q55BU3", "DDB_G0270360", "Q55EN0", "DDB_G0269006", "Q54QF2", "DDB_G0283901", "Q54MH4", "DDB_G0285843", "Q54LV5", "DDB_G0286395", "Q54GS9", "DDB_G0289933", "Q54MH3", "DDB_G0285937", "Q1ZXB1", "DDB_G0291966", "Q54PX3", "DDB_G0291966", "Q54HF5", "DDB_G0289501", "Q54Z08", "DDB_G0277977", "Q55EC6", "DDB_G0269300", "Q55D61", "DDB_G0269192", "Q54V94", "DDB_G0280529", "Q54XS9", "DDB_G0278769", "Q54LG7", "DDB_G0286645", "Q54WL8", "DDB_G0279559", "Q54N48", "DDB_G0285507", "Q54J73", "DDB_G0288259", "Q55E68", "DDB_G0269370", "Q54ZS8", "DDB_G0277371", "Q55BS1", "DDB_G0270392", "Q55CA3", "DDB_G0270148", "Q54PX4", "DDB_G0284319", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797", "C7G084", "DDB_G0295793", "Q54TS6", "DDB_G0281585", "P54705", "DDB_G0269188", "Q86A78", "DDB_G0274577", "Q54FZ3", "DDB_G0290649", "Q54NB4", "DDB_G0285363", "Q54NB3", "DDB_G0285363", "Q9NI62", "DDB_G0269216", "Q54E37", "DDB_G0291836", "Q54YS7", "DDB_G0278105", "Q54VI2", "DDB_G0280393", "Q54CE0", "DDB_G0293168", "Q54PW8", "DDB_G0284321", "Q54WE9", "DDB_G0279695", "Q86I71", "DDB_G0279695", "Q55G43", "DDB_G0268358", "Q55G70", "DDB_G0267796", "Q555Z2", "DDB_G0274797", "DDB_G0278929", "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q54YA5", "DDB_G0278335", "Q55FQ0", "DDB_G0268004", "Q54J05", "DDB_G0288391", "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q54K20", "DDB_G0287635", "Q86J17", "DDB_G0274281", "Q8T2A7", "DDB_G0274213", "Q54ST0", "DDB_G0282243", "C7G068", "DDB_G0289595", "DDB_G0274361" ] }, "reaction_10579630": { "compartment": "compartment_7660", "id": "reaction_10579630", "reactome": "R-DDI-72139", "name": "Formation of the active Spliceosomal C (B*) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10579623" ], "products": [ "species_10579627", "species_10579617" ], "modifiers": [ [ "species_10579623", "catalyst" ] ], "additional_components": [ "Q54LT3", "DDB_G0286425", "Q54NS6", "DDB_G0285077", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55BF5", "DDB_G0271312", "Q86JC5", "DDB_G0275957", "Q1ZXF6", "DDB_G0284555", "Q54LY9", "DDB_G0286297", "Q54IV3", "DDB_G0288501", "Q54SA7", "DDB_G0282569", "Q54BG2", "DDB_G0293636", "Q54PP4", "DDB_G0284403", "Q54TL3", "DDB_G0281687", "Q55CI7", "DDB_G0271014", "Q54Q46", "DDB_G0284101", "Q54J05", "DDB_G0288391", "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q553B1", "DDB_G0275443", "Q54NJ4", "DDB_G0285213", "Q55BL6", "DDB_G0270450", "Q86A14", "DDB_G0272676", "Q54B65", "DDB_G0293876", "Q55CK7", "DDB_G0270020", "Q557T0", "DDB_G0273383", "Q7KWK5", "DDB_G0276803", "Q54SG7", "DDB_G0282763", "Q54WZ0", "DDB_G0279311", "Q54CN1", "DDB_G0292846", "P36415", "DDB_G0269144", "Q54WP9", "DDB_G0279507", "Q54CT3", "DDB_G0292778", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54ZS5", "DDB_G0277375", "Q54N41", "DDB_G0285521", "Q55A46", "DDB_G0272108", "Q54XP4", "DDB_G0278819", "Q8T295", "DDB_G0274229", "Q54ST0", "DDB_G0282243", "Q553S5", "DDB_G0275407", "Q55A15", "DDB_G0272374", "Q54R72", "DDB_G0283359", "Q55AR8", "DDB_G0271788", "Q54TF6", "DDB_G0281779", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q55BU3", "DDB_G0270360", "Q55EN0", "DDB_G0269006", "Q54QF2", "DDB_G0283901", "Q54MH4", "DDB_G0285843", "Q54LV5", "DDB_G0286395", "Q54GS9", "DDB_G0289933", "Q54MH3", "DDB_G0285937", "Q1ZXB1", "DDB_G0291966", "Q54PX3", "DDB_G0291966", "Q54HF5", "DDB_G0289501", "Q54Z08", "DDB_G0277977", "Q55EC6", "DDB_G0269300", "Q55D61", "DDB_G0269192", "Q54V94", "DDB_G0280529", "Q54XS9", "DDB_G0278769", "Q54LG7", "DDB_G0286645", "Q54WL8", "DDB_G0279559", "Q54N48", "DDB_G0285507", "Q54J73", "DDB_G0288259", "Q55E68", "DDB_G0269370", "Q54ZS8", "DDB_G0277371", "Q55BS1", "DDB_G0270392", "Q55CA3", "DDB_G0270148", "Q54PX4", "DDB_G0284319", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797", "C7G084", "DDB_G0295793", "Q54TS6", "DDB_G0281585", "P54705", "DDB_G0269188", "Q86A78", "DDB_G0274577", "Q54FZ3", "DDB_G0290649", "Q54NB4", "DDB_G0285363", "Q54NB3", "DDB_G0285363", "Q9NI62", "DDB_G0269216", "Q54E37", "DDB_G0291836", "Q54YS7", "DDB_G0278105", "Q54VI2", "DDB_G0280393", "Q54CE0", "DDB_G0293168", "Q54PW8", "DDB_G0284321", "Q54WE9", "DDB_G0279695", "Q86I71", "DDB_G0279695", "Q55G43", "DDB_G0268358", "Q55G70", "DDB_G0267796", "Q555Z2", "DDB_G0274797", "Q55G70", "DDB_G0267796", "Q54LT3", "DDB_G0286425", "Q54NS6", "DDB_G0285077", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55BF5", "DDB_G0271312", "Q86JC5", "DDB_G0275957", "Q1ZXF6", "DDB_G0284555", "Q54LY9", "DDB_G0286297", "Q54IV3", "DDB_G0288501", "Q54SA7", "DDB_G0282569", "Q54BG2", "DDB_G0293636", "Q54PP4", "DDB_G0284403", "Q54TL3", "DDB_G0281687", "Q55CI7", "DDB_G0271014", "Q54Q46", "DDB_G0284101", "Q54J05", "DDB_G0288391", "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q553B1", "DDB_G0275443", "Q54NJ4", "DDB_G0285213", "Q55BL6", "DDB_G0270450", "Q86A14", "DDB_G0272676", "Q54B65", "DDB_G0293876", "Q55CK7", "DDB_G0270020", "Q557T0", "DDB_G0273383", "Q7KWK5", "DDB_G0276803", "Q54SG7", "DDB_G0282763", "Q54WZ0", "DDB_G0279311", "Q54CN1", "DDB_G0292846", "P36415", "DDB_G0269144", "Q54WP9", "DDB_G0279507", "Q54CT3", "DDB_G0292778", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54ZS5", "DDB_G0277375", "Q54N41", "DDB_G0285521", "Q55A46", "DDB_G0272108", "Q54XP4", "DDB_G0278819", "Q8T295", "DDB_G0274229", "Q54ST0", "DDB_G0282243", "Q553S5", "DDB_G0275407", "Q55A15", "DDB_G0272374", "Q54R72", "DDB_G0283359", "Q55AR8", "DDB_G0271788", "Q54TF6", "DDB_G0281779", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q55BU3", "DDB_G0270360", "Q55EN0", "DDB_G0269006", "Q54QF2", "DDB_G0283901", "Q54MH4", "DDB_G0285843", "Q54LV5", "DDB_G0286395", "Q54GS9", "DDB_G0289933", "Q54MH3", "DDB_G0285937", "Q1ZXB1", "DDB_G0291966", "Q54PX3", "DDB_G0291966", "Q54HF5", "DDB_G0289501", "Q54Z08", "DDB_G0277977", "Q55EC6", "DDB_G0269300", "Q55D61", "DDB_G0269192", "Q54V94", "DDB_G0280529", "Q54XS9", "DDB_G0278769", "Q54LG7", "DDB_G0286645", "Q54WL8", "DDB_G0279559", "Q54N48", "DDB_G0285507", "Q54J73", "DDB_G0288259", "Q55E68", "DDB_G0269370", "Q54ZS8", "DDB_G0277371", "Q55BS1", "DDB_G0270392", "Q55CA3", "DDB_G0270148", "Q54PX4", "DDB_G0284319", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797", "C7G084", "DDB_G0295793", "Q54TS6", "DDB_G0281585", "P54705", "DDB_G0269188", "Q86A78", "DDB_G0274577", "Q54FZ3", "DDB_G0290649", "Q54NB4", "DDB_G0285363", "Q54NB3", "DDB_G0285363", "Q9NI62", "DDB_G0269216", "Q54E37", "DDB_G0291836", "Q54YS7", "DDB_G0278105", "Q54VI2", "DDB_G0280393", "Q54CE0", "DDB_G0293168", "Q54PW8", "DDB_G0284321", "Q54WE9", "DDB_G0279695", "Q86I71", "DDB_G0279695", "Q555Z2", "DDB_G0274797", "DDB_G0268358", "Q54LT3", "DDB_G0286425", "Q54NS6", "DDB_G0285077", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55BF5", "DDB_G0271312", "Q86JC5", "DDB_G0275957", "Q1ZXF6", "DDB_G0284555", "Q54LY9", "DDB_G0286297", "Q54IV3", "DDB_G0288501", "Q54SA7", "DDB_G0282569", "Q54BG2", "DDB_G0293636", "Q54PP4", "DDB_G0284403", "Q54TL3", "DDB_G0281687", "Q55CI7", "DDB_G0271014", "Q54Q46", "DDB_G0284101", "Q54J05", "DDB_G0288391", "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q553B1", "DDB_G0275443", "Q54NJ4", "DDB_G0285213", "Q55BL6", "DDB_G0270450", "Q86A14", "DDB_G0272676", "Q54B65", "DDB_G0293876", "Q55CK7", "DDB_G0270020", "Q557T0", "DDB_G0273383", "Q7KWK5", "DDB_G0276803", "Q54SG7", "DDB_G0282763", "Q54WZ0", "DDB_G0279311", "Q54CN1", "DDB_G0292846", "P36415", "DDB_G0269144", "Q54WP9", "DDB_G0279507", "Q54CT3", "DDB_G0292778", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54ZS5", "DDB_G0277375", "Q54N41", "DDB_G0285521", "Q55A46", "DDB_G0272108", "Q54XP4", "DDB_G0278819", "Q8T295", "DDB_G0274229", "Q54ST0", "DDB_G0282243", "Q553S5", "DDB_G0275407", "Q55A15", "DDB_G0272374", "Q54R72", "DDB_G0283359", "Q55AR8", "DDB_G0271788", "Q54TF6", "DDB_G0281779", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q55BU3", "DDB_G0270360", "Q55EN0", "DDB_G0269006", "Q54QF2", "DDB_G0283901", "Q54MH4", "DDB_G0285843", "Q54LV5", "DDB_G0286395", "Q54GS9", "DDB_G0289933", "Q54MH3", "DDB_G0285937", "Q1ZXB1", "DDB_G0291966", "Q54PX3", "DDB_G0291966", "Q54HF5", "DDB_G0289501", "Q54Z08", "DDB_G0277977", "Q55EC6", "DDB_G0269300", "Q55D61", "DDB_G0269192", "Q54V94", "DDB_G0280529", "Q54XS9", "DDB_G0278769", "Q54LG7", "DDB_G0286645", "Q54WL8", "DDB_G0279559", "Q54N48", "DDB_G0285507", "Q54J73", "DDB_G0288259", "Q55E68", "DDB_G0269370", "Q54ZS8", "DDB_G0277371", "Q55BS1", "DDB_G0270392", "Q55CA3", "DDB_G0270148", "Q54PX4", "DDB_G0284319", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797", "C7G084", "DDB_G0295793", "Q54TS6", "DDB_G0281585", "P54705", "DDB_G0269188", "Q86A78", "DDB_G0274577", "Q54FZ3", "DDB_G0290649", "Q54NB4", "DDB_G0285363", "Q54NB3", "DDB_G0285363", "Q9NI62", "DDB_G0269216", "Q54E37", "DDB_G0291836", "Q54YS7", "DDB_G0278105", "Q54VI2", "DDB_G0280393", "Q54CE0", "DDB_G0293168", "Q54PW8", "DDB_G0284321", "Q54WE9", "DDB_G0279695", "Q86I71", "DDB_G0279695", "Q55G43", "DDB_G0268358", "Q55G70", "DDB_G0267796", "Q555Z2", "DDB_G0274797" ] }, "reaction_10581544": { "compartment": "compartment_7660", "id": "reaction_10581544", "reactome": "R-DDI-75079", "name": "Formation of AT-AC C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581540" ], "products": [ "species_10581532", "species_10581542" ], "modifiers": [], "additional_components": [ "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q8T295", "DDB_G0274229", "Q54ST0", "DDB_G0282243", "Q553S5", "DDB_G0275407", "Q55A15", "DDB_G0272374", "Q54R72", "DDB_G0283359", "Q55AR8", "DDB_G0271788", "Q54TF6", "DDB_G0281779", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q1ZXB1", "DDB_G0291966", "Q54PX3", "DDB_G0291966", "Q55BF5", "DDB_G0271312", "Q86JC5", "DDB_G0275957", "Q1ZXF6", "DDB_G0284555", "Q54LY9", "DDB_G0286297", "Q54IV3", "DDB_G0288501", "Q54SA7", "DDB_G0282569", "Q55CC1", "DDB_G0270734", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q1ZXB1", "DDB_G0291966", "Q54PX3", "DDB_G0291966", "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q8T295", "DDB_G0274229", "Q54ST0", "DDB_G0282243", "Q553S5", "DDB_G0275407", "Q55A15", "DDB_G0272374", "Q54R72", "DDB_G0283359", "Q55AR8", "DDB_G0271788", "Q54TF6", "DDB_G0281779", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q55BF5", "DDB_G0271312", "Q86JC5", "DDB_G0275957", "Q1ZXF6", "DDB_G0284555", "Q54LY9", "DDB_G0286297", "Q54IV3", "DDB_G0288501", "Q54SA7", "DDB_G0282569", "Q55CC1", "DDB_G0270734", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10581546": { "compartment": "compartment_7660", "id": "reaction_10581546", "reactome": "R-DDI-75082", "name": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581542" ], "products": [ "species_10581542" ], "modifiers": [], "additional_components": [ "Q1ZXB1", "DDB_G0291966", "Q54PX3", "DDB_G0291966", "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q8T295", "DDB_G0274229", "Q54ST0", "DDB_G0282243", "Q553S5", "DDB_G0275407", "Q55A15", "DDB_G0272374", "Q54R72", "DDB_G0283359", "Q55AR8", "DDB_G0271788", "Q54TF6", "DDB_G0281779", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q55BF5", "DDB_G0271312", "Q86JC5", "DDB_G0275957", "Q1ZXF6", "DDB_G0284555", "Q54LY9", "DDB_G0286297", "Q54IV3", "DDB_G0288501", "Q54SA7", "DDB_G0282569", "Q55CC1", "DDB_G0270734", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q1ZXB1", "DDB_G0291966", "Q54PX3", "DDB_G0291966", "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q8T295", "DDB_G0274229", "Q54ST0", "DDB_G0282243", "Q553S5", "DDB_G0275407", "Q55A15", "DDB_G0272374", "Q54R72", "DDB_G0283359", "Q55AR8", "DDB_G0271788", "Q54TF6", "DDB_G0281779", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q55BF5", "DDB_G0271312", "Q86JC5", "DDB_G0275957", "Q1ZXF6", "DDB_G0284555", "Q54LY9", "DDB_G0286297", "Q54IV3", "DDB_G0288501", "Q54SA7", "DDB_G0282569", "Q55CC1", "DDB_G0270734", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10590100": { "compartment": "compartment_876", "id": "reaction_10590100", "reactome": "R-DDI-381608", "name": "cAMP activates EPAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10590096" ], "products": [ "species_10590098" ], "modifiers": [], "additional_components": [ "Q54TK8", "DDB_G0281573", "Q8IS12", "DDB_G0275703", "Q54TK8", "DDB_G0281573", "Q8IS12", "DDB_G0275703", "species_30389" ] }, "reaction_10590135": { "compartment": "compartment_876", "id": "reaction_10590135", "reactome": "R-DDI-381668", "name": "cAMP activates EPAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10590131" ], "products": [ "species_10590133" ], "modifiers": [], "additional_components": [ "Q8IS12", "DDB_G0275703", "Q54TK8", "DDB_G0281573", "Q8IS12", "DDB_G0275703", "Q54TK8", "DDB_G0281573", "species_30389" ] }, "reaction_10590141": { "compartment": "compartment_70101", "id": "reaction_10590141", "reactome": "R-DDI-381727", "name": "RAP1A exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10590137" ], "products": [ "species_29420", "species_10590139" ], "modifiers": [ [ "species_10590133", "catalyst" ], [ "species_10590098", "catalyst" ] ], "additional_components": [ "species_29420", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "species_29438", "Q8IS12", "DDB_G0275703", "Q54TK8", "DDB_G0281573", "species_30389", "Q54TK8", "DDB_G0281573", "Q8IS12", "DDB_G0275703", "species_30389" ] }, "reaction_10590124": { "compartment": "compartment_12045", "id": "reaction_10590124", "reactome": "R-DDI-381644", "name": "ER calcium channels open in response to activated PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590114" ], "products": [ "species_10590122" ], "modifiers": [ [ "species_10582991", "catalyst" ] ], "additional_components": [ "Q9NA13", "DDB_G0292564", "Q9NA13", "DDB_G0292564", "species_114520", "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029" ] }, "reaction_10586788": { "compartment": "compartment_70101", "id": "reaction_10586788", "reactome": "R-DDI-196402", "name": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_195655", "species_29364" ], "products": [ "species_29366", "species_196420" ], "modifiers": [ [ "species_10586785", "catalyst" ] ], "additional_components": [ "DDB_G0284407" ] }, "reaction_10586760": { "compartment": "compartment_12045", "id": "reaction_10586760", "reactome": "R-DDI-195690", "name": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194691" ], "products": [ "species_195691" ], "modifiers": [ [ "species_10586757", "catalyst" ] ], "additional_components": [ "DDB_G0269414" ] }, "reaction_10627239": { "compartment": "compartment_984", "id": "reaction_10627239", "reactome": "R-DDI-9673054", "name": "PM20D1 hydrolyzes oleoyl-phe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_9673044" ], "products": [ "species_351993", "species_9673048" ], "modifiers": [ [ "species_10627234", "catalyst" ] ], "additional_components": [ "DDB_G0270582" ] }, "reaction_10627237": { "compartment": "compartment_984", "id": "reaction_10627237", "reactome": "R-DDI-9673053", "name": "PM20D1 transforms oleoyl-phe from oleate and phe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351993", "species_9673048" ], "products": [ "species_109276", "species_9673044" ], "modifiers": [ [ "species_10627234", "catalyst" ] ], "additional_components": [ "DDB_G0270582" ] }, "reaction_10594189": { "compartment": "compartment_70101", "id": "reaction_10594189", "reactome": "R-DDI-874087", "name": "SGT1 binds HSP90", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594185", "species_10594183" ], "products": [ "species_10594187" ], "modifiers": [], "additional_components": [ "DDB_G0267400", "DDB_G0269292", "Q55ED0", "DDB_G0269292", "P54651", "DDB_G0267400" ] }, "reaction_10590742": { "compartment": "compartment_876", "id": "reaction_10590742", "reactome": "R-DDI-418309", "name": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016" ], "products": [ "species_74112" ], "modifiers": [ [ "species_10590739", "catalyst" ] ], "additional_components": [ "P54678", "DDB_G0277861", "Q54HG6", "DDB_G0289473", "Q54PE8", "DDB_G0289473" ] }, "reaction_10613009": { "compartment": "compartment_7660", "id": "reaction_10613009", "reactome": "R-DDI-6791219", "name": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612993" ], "products": [ "species_10612972" ], "modifiers": [ [ "species_10612963", "catalyst" ], [ "species_10612968", "catalyst" ], [ "species_10613007", "catalyst" ], [ "species_10612991", "catalyst" ] ], "additional_components": [ "Q75JW2", "DDB_G0272176", "Q54Z27", "DDB_G0277945", "Q54DG4", "DDB_G0292290", "Q54W97", "DDB_G0279809", "Q55DQ9", "DDB_G0270828", "Q54IM3", "DDB_G0288659", "Q54TD8", "DDB_G0281839", "Q54HJ2", "DDB_G0289415", "Q54W52", "DDB_G0279903", "Q75JW2", "DDB_G0272176", "Q54Z27", "DDB_G0277945", "Q54DG4", "DDB_G0292290", "Q54W97", "DDB_G0279809", "Q55DQ9", "DDB_G0270828", "Q54IM3", "DDB_G0288659", "DDB_G0272176", "DDB_G0277945", "Q54P34", "DDB_G0284817", "Q54HJ2", "DDB_G0289415", "Q54KS4", "DDB_G0287147", "Q54TD8", "DDB_G0281839", "Q54HJ2", "DDB_G0289415", "Q54W52", "DDB_G0279903" ] }, "reaction_10613443": { "compartment": "compartment_70101", "id": "reaction_10613443", "reactome": "R-DDI-6791223", "name": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613417", "species_10613415" ], "products": [ "species_10613423", "species_10613421", "species_10613435", "species_10613419", "species_10613433", "species_10613417", "species_10579913", "species_10613431", "species_10613429", "species_10613427", "species_10613425" ], "modifiers": [ [ "species_10613423", "catalyst" ], [ "species_10613433", "catalyst" ], [ "species_10613441", "catalyst" ], [ "species_10613435", "catalyst" ] ], "additional_components": [ "DDB_G0280431", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "P90526", "DDB_G0293000", "P14132", "DDB_G0289877", "Q76P36", "DDB_G0272308", "Q54U04", "DDB_G0281409", "Q54I41", "DDB_G0289025", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "Q54UU3", "DDB_G0280823", "Q54GC0", "DDB_G0290281", "P27685", "DDB_G0293742", "Q556Y4", "DDB_G0273059", "Q54TL8", "DDB_G0281677", "Q03409", "DDB_G0271148", "Q54VD8", "DDB_G0280431", "Q54BN4", "DDB_G0293700", "Q54YA7", "DDB_G0278331", "Q54Y41", "DDB_G0278429", "Q54X51", "DDB_G0279207", "Q869U7", "DDB_G0276415", "P42520", "DDB_G0290141", "Q54T05", "DDB_G0282099", "Q54N17", "DDB_G0285561", "Q54K66", "DDB_G0287557", "Q54PX9", "DDB_G0284237", "O77082", "DDB_G0286117", "Q54E24", "DDB_G0291864", "Q54MA6", "DDB_G0286075", "Q54W91", "DDB_G0279821", "Q54ZW5", "DDB_G0277345", "Q75K27", "DDB_G0275473", "Q8T1D4", "DDB_G0275601", "Q8T1V4", "DDB_G0277635", "Q54MZ5", "DDB_G0285597", "Q55A19", "DDB_G0272250", "Q54Q51", "DDB_G0284093", "P46793", "DDB_G0276457", "Q54IS0", "DDB_G0288565", "Q54PH8", "DDB_G0284533", "Q54S90", "DDB_G0282601", "Q54W23", "DDB_G0279961", "P51405", "DDB_G0272825", "Q3ZE13", "DDB_G0269980", "DDB_G0279821", "DDB_G0275601", "DDB_G0273059", "DDB_G0288565", "DDB_G0273059", "DDB_G0280431", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "DDB_G0280431", "DDB_G0278331", "DDB_G0282099", "DDB_G0287557", "DDB_G0279821", "DDB_G0273059", "DDB_G0269722", "DDB_G0273059" ] }, "reaction_10613285": { "compartment": "compartment_7660", "id": "reaction_10613285", "reactome": "R-DDI-6791222", "name": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613233" ], "products": [ "species_10613241" ], "modifiers": [ [ "species_10613282", "catalyst" ], [ "species_10613246", "catalyst" ], [ "species_10613265", "catalyst" ], [ "species_10613280", "catalyst" ] ], "additional_components": [ "Q54JS8", "DDB_G0287891", "Q54S38", "DDB_G0282803", "Q553S0", "DDB_G0275403", "Q54WV7", "DDB_G0279371", "Q55GM5", "DDB_G0267606", "Q54HT2", "DDB_G0289235", "Q54X28", "DDB_G0279245", "Q54XG2", "DDB_G0278983", "C7G018", "DDB_G0302418", "Q54KG8", "DDB_G0287351", "Q7KWM6", "DDB_G0272732", "Q55BA1", "DDB_G0271240", "Q54PE0", "DDB_G0284621", "Q54WN5", "DDB_G0279601", "Q550V0", "DDB_G0277019", "Q54S79", "DDB_G0282623", "Q7KWS8", "DDB_G0276283", "Q54UU6", "DDB_G0280805", "Q86IZ9", "DDB_G0274325", "Q54BV0", "DDB_G0293412", "Q54ST0", "DDB_G0282243", "Q55CW0", "DDB_G0269878", "Q55FI4", "DDB_G0268098", "Q54MT2", "DDB_G0285679", "Q54VT4", "DDB_G0280147", "Q54EN2", "DDB_G0291438", "Q54XT8", "DDB_G0278751", "Q55D06", "DDB_G0269830", "Q54GG4", "DDB_G0290181", "Q54K79", "DDB_G0287537", "Q7KWL3", "DDB_G0276815", "P27685", "DDB_G0293742", "Q54VA5", "DDB_G0280489", "Q54UU3", "DDB_G0280823", "Q54I41", "DDB_G0289025", "P14132", "DDB_G0289877", "Q8T2Q3", "DDB_G0275141", "Q55EH5", "DDB_G0268898", "Q54QV4", "DDB_G0283581", "Q54ML4", "DDB_G0285875", "Q55C50", "DDB_G0270230", "Q54EG3", "DDB_G0291526", "Q54JS8", "DDB_G0287891", "Q54S38", "DDB_G0282803", "Q553S0", "DDB_G0275403", "Q54WV7", "DDB_G0279371", "Q55GM5", "DDB_G0267606", "Q54HT2", "DDB_G0289235", "Q54X28", "DDB_G0279245", "Q54XG2", "DDB_G0278983", "C7G018", "DDB_G0302418", "Q54KG8", "DDB_G0287351", "Q7KWM6", "DDB_G0272732", "Q55BA1", "DDB_G0271240", "Q54PE0", "DDB_G0284621", "Q54WN5", "DDB_G0279601", "Q550V0", "DDB_G0277019", "Q54S79", "DDB_G0282623", "Q7KWS8", "DDB_G0276283", "Q54UU6", "DDB_G0280805", "Q86IZ9", "DDB_G0274325", "Q54BV0", "DDB_G0293412", "Q54ST0", "DDB_G0282243", "Q55CW0", "DDB_G0269878", "Q55FI4", "DDB_G0268098", "Q54MT2", "DDB_G0285679", "Q54VT4", "DDB_G0280147", "Q54EN2", "DDB_G0291438", "Q54XT8", "DDB_G0278751", "Q55D06", "DDB_G0269830", "Q54GG4", "DDB_G0290181", "Q54K79", "DDB_G0287537", "Q7KWL3", "DDB_G0276815", "P27685", "DDB_G0293742", "Q54VA5", "DDB_G0280489", "Q54UU3", "DDB_G0280823", "Q54I41", "DDB_G0289025", "P14132", "DDB_G0289877", "Q8T2Q3", "DDB_G0275141", "Q55EH5", "DDB_G0268898", "Q54QV4", "DDB_G0283581", "Q54ML4", "DDB_G0285875", "Q55C50", "DDB_G0270230", "Q54EG3", "DDB_G0291526", "Q86IE2", "DDB_G0275633", "Q54ZS3", "DDB_G0277279", "Q55AW0", "DDB_G0271572", "Q54Q83", "DDB_G0284053", "Q55BB0", "DDB_G0271396", "Q54VM4", "DDB_G0280251", "Q54CU6", "DDB_G0292692", "Q54N99", "DDB_G0285377", "Q55BJ2", "DDB_G0271100", "Q54EV5", "DDB_G0291310", "Q7KWX9", "DDB_G0276783", "Q54EU6", "DDB_G0291328", "DDB_G0271572", "DDB_G0284053", "DDB_G0275633" ] }, "reaction_10613464": { "compartment": "compartment_7660", "id": "reaction_10613464", "reactome": "R-DDI-6791227", "name": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613450" ], "products": [ "species_10613454" ], "modifiers": [ [ "species_10613459", "catalyst" ], [ "species_10613107", "catalyst" ], [ "species_10613131", "catalyst" ], [ "species_10613462", "catalyst" ], [ "species_10613085", "catalyst" ], [ "species_10613280", "catalyst" ] ], "additional_components": [ "Q54JS8", "DDB_G0287891", "Q54S38", "DDB_G0282803", "Q553S0", "DDB_G0275403", "Q54WV7", "DDB_G0279371", "Q55GM5", "DDB_G0267606", "Q54HT2", "DDB_G0289235", "Q54X28", "DDB_G0279245", "Q54XG2", "DDB_G0278983", "C7G018", "DDB_G0302418", "Q54KG8", "DDB_G0287351", "Q7KWM6", "DDB_G0272732", "Q55BA1", "DDB_G0271240", "Q54PE0", "DDB_G0284621", "Q54WN5", "DDB_G0279601", "Q550V0", "DDB_G0277019", "Q54S79", "DDB_G0282623", "Q7KWS8", "DDB_G0276283", "Q54UU6", "DDB_G0280805", "Q86IZ9", "DDB_G0274325", "Q54BV0", "DDB_G0293412", "Q54ST0", "DDB_G0282243", "Q55CW0", "DDB_G0269878", "Q55FI4", "DDB_G0268098", "Q54MT2", "DDB_G0285679", "Q54VT4", "DDB_G0280147", "Q54EN2", "DDB_G0291438", "Q54XT8", "DDB_G0278751", "Q55D06", "DDB_G0269830", "Q54GG4", "DDB_G0290181", "Q54K79", "DDB_G0287537", "Q7KWL3", "DDB_G0276815", "P27685", "DDB_G0293742", "Q54VA5", "DDB_G0280489", "Q54UU3", "DDB_G0280823", "Q54I41", "DDB_G0289025", "P14132", "DDB_G0289877", "Q8T2Q3", "DDB_G0275141", "Q55EH5", "DDB_G0268898", "Q54QV4", "DDB_G0283581", "Q54ML4", "DDB_G0285875", "Q55C50", "DDB_G0270230", "Q54EG3", "DDB_G0291526", "Q54JS8", "DDB_G0287891", "Q54S38", "DDB_G0282803", "Q553S0", "DDB_G0275403", "Q54WV7", "DDB_G0279371", "Q55GM5", "DDB_G0267606", "Q54HT2", "DDB_G0289235", "Q54X28", "DDB_G0279245", "Q54XG2", "DDB_G0278983", "C7G018", "DDB_G0302418", "Q54KG8", "DDB_G0287351", "Q7KWM6", "DDB_G0272732", "Q55BA1", "DDB_G0271240", "Q54PE0", "DDB_G0284621", "Q54WN5", "DDB_G0279601", "Q550V0", "DDB_G0277019", "Q54S79", "DDB_G0282623", "Q7KWS8", "DDB_G0276283", "Q54UU6", "DDB_G0280805", "Q86IZ9", "DDB_G0274325", "Q54BV0", "DDB_G0293412", "Q54ST0", "DDB_G0282243", "Q55CW0", "DDB_G0269878", "Q55FI4", "DDB_G0268098", "Q54MT2", "DDB_G0285679", "Q54VT4", "DDB_G0280147", "Q54EN2", "DDB_G0291438", "Q54XT8", "DDB_G0278751", "Q55D06", "DDB_G0269830", "Q54GG4", "DDB_G0290181", "Q54K79", "DDB_G0287537", "Q7KWL3", "DDB_G0276815", "P27685", "DDB_G0293742", "Q54VA5", "DDB_G0280489", "Q54UU3", "DDB_G0280823", "Q54I41", "DDB_G0289025", "P14132", "DDB_G0289877", "Q8T2Q3", "DDB_G0275141", "Q55EH5", "DDB_G0268898", "Q54QV4", "DDB_G0283581", "Q54ML4", "DDB_G0285875", "Q55C50", "DDB_G0270230", "Q54EG3", "DDB_G0291526", "DDB_G0269922", "DDB_G0271240", "Q54EN2", "DDB_G0291438", "Q54XT8", "DDB_G0278751", "Q55D06", "DDB_G0269830", "DDB_G0291836", "Q8T2Q3", "DDB_G0275141", "Q55EH5", "DDB_G0268898", "Q54QV4", "DDB_G0283581", "Q54ML4", "DDB_G0285875", "DDB_G0275633" ] }, "reaction_10590291": { "compartment": "compartment_17951", "id": "reaction_10590291", "reactome": "R-DDI-389550", "name": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389548", "species_389556" ], "products": [ "species_193465", "species_389536", "species_389537", "species_113602" ], "modifiers": [ [ "species_10590288", "catalyst" ] ], "additional_components": [ "Q75JR2", "DDB_G0272210" ] }, "reaction_10617763": { "compartment": "compartment_70101", "id": "reaction_10617763", "reactome": "R-DDI-6811504", "name": "AKT1 dephosphorylation by PP2A-B56-beta,gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10586949" ], "products": [ "species_10590479", "species_29372" ], "modifiers": [ [ "species_10617760", "catalyst" ], [ "species_1806240", "inhibitor" ] ], "additional_components": [ "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "Q54VB6", "DDB_G0280469" ] }, "reaction_10598646": { "compartment": "compartment_876", "id": "reaction_10598646", "reactome": "R-DDI-1675776", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806240", "species_113592" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10598643", "catalyst" ] ], "additional_components": [ "Q86D86", "DDB_G0283615", "Q54DL4", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635" ] }, "reaction_10599019": { "compartment": "compartment_876", "id": "reaction_10599019", "reactome": "R-DDI-1676082", "name": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10598592", "catalyst" ] ], "additional_components": [ "Q54M96", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635", "Q54VR4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q86D86", "DDB_G0283615", "Q54DL4", "DDB_G0292190" ] }, "reaction_10611344": { "compartment": "compartment_7660", "id": "reaction_10611344", "reactome": "R-DDI-5693533", "name": "DCLRE1C (ARTEMIS) processes DNA DSB ends", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608592" ], "products": [ "species_10611341" ], "modifiers": [ [ "species_10608592", "catalyst" ] ], "additional_components": [ "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303" ] }, "reaction_10611360": { "compartment": "compartment_7660", "id": "reaction_10611360", "reactome": "R-DDI-5693574", "name": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611358", "species_10608604", "species_10608613", "species_10608611" ], "products": [ "species_10608617" ], "modifiers": [], "additional_components": [ "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54CR9", "DDB_G0292760", "Q54YJ7", "DDB_G0278203", "DDB_G0284713", "Q54P54", "DDB_G0284785", "Q54P54", "DDB_G0284785", "Q1ZXF2", "DDB_G0284713", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54CR9", "DDB_G0292760", "Q54YJ7", "DDB_G0278203" ] }, "reaction_10608595": { "compartment": "compartment_7660", "id": "reaction_10608595", "reactome": "R-DDI-5687183", "name": "PRKDC phosphorylates DCLRE1C at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10608588" ], "products": [ "species_113582", "species_10608592" ], "modifiers": [ [ "species_10608588", "catalyst" ] ], "additional_components": [ "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303" ] }, "reaction_10611369": { "compartment": "compartment_7660", "id": "reaction_10611369", "reactome": "R-DDI-5693575", "name": "DNA-PKcs autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611366" ], "products": [ "species_113582", "species_10608586" ], "modifiers": [ [ "species_10611366", "catalyst" ] ], "additional_components": [ "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303" ] }, "reaction_10611384": { "compartment": "compartment_7660", "id": "reaction_10611384", "reactome": "R-DDI-5693578", "name": "TDP1 and TDP2 process unligatable DSB ends", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611341" ], "products": [ "species_10611358" ], "modifiers": [ [ "species_10611381", "catalyst" ] ], "additional_components": [ "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303" ] }, "reaction_10611390": { "compartment": "compartment_7660", "id": "reaction_10611390", "reactome": "R-DDI-5693615", "name": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611388", "species_10611362" ], "products": [ "species_10611366" ], "modifiers": [], "additional_components": [ "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "DDB_G0281167", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303" ] }, "reaction_10608622": { "compartment": "compartment_7660", "id": "reaction_10608622", "reactome": "R-DDI-5687360", "name": "POLL or POLM extends aligned DNA DSB ends to fill gaps", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10608617" ], "products": [ "species_10608619", "species_113541" ], "modifiers": [ [ "species_10608617", "catalyst" ] ], "additional_components": [ "Q54P54", "DDB_G0284785", "Q1ZXF2", "DDB_G0284713", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54CR9", "DDB_G0292760", "Q54YJ7", "DDB_G0278203", "Q54P54", "DDB_G0284785", "Q1ZXF2", "DDB_G0284713", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54CR9", "DDB_G0292760", "Q54YJ7", "DDB_G0278203", "Q54P54", "DDB_G0284785", "Q1ZXF2", "DDB_G0284713", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54CR9", "DDB_G0292760", "Q54YJ7", "DDB_G0278203" ] }, "reaction_10599936": { "compartment": "compartment_70101", "id": "reaction_10599936", "reactome": "R-DDI-2029456", "name": "RAC1 and CDC42 activate PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590366", "species_10583374" ], "products": [ "species_10590364", "species_10599932" ], "modifiers": [], "additional_components": [ "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "P34144", "DDB_G0277869", "species_29438", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10600039": { "compartment": "compartment_70101", "id": "reaction_10600039", "reactome": "R-DDI-2029473", "name": "Branching and elongation of mother and daughter filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600037", "species_10587698" ], "products": [ "species_10599621" ], "modifiers": [], "additional_components": [ "O96626", "DDB_G0288319", "O96622", "DDB_G0277825", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54L54", "DDB_G0286893", "species_29370", "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54L54", "DDB_G0286893", "species_113592", "O96626", "DDB_G0288319", "O96622", "DDB_G0277825", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54L54", "DDB_G0286893" ] }, "reaction_10599993": { "compartment": "compartment_70101", "id": "reaction_10599993", "reactome": "R-DDI-2029466", "name": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599576", "species_10599989" ], "products": [ "species_10599991" ], "modifiers": [], "additional_components": [ "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54L54", "DDB_G0286893", "species_113592", "O96626", "DDB_G0288319", "O96622", "DDB_G0277825", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "species_179838", "Q869Q3", "DDB_G0274519", "Q55FT9", "DDB_G0267956", "Q54X65", "DDB_G0279175", "Q6UK63", "DDB_G0287855", "P34144", "DDB_G0277869", "species_29438", "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54L54", "DDB_G0286893", "O96626", "DDB_G0288319", "O96622", "DDB_G0277825", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "species_179838", "Q869Q3", "DDB_G0274519", "Q55FT9", "DDB_G0267956", "Q54X65", "DDB_G0279175", "Q6UK63", "DDB_G0287855", "P34144", "DDB_G0277869", "species_29438", "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54L54", "DDB_G0286893" ] }, "reaction_10600666": { "compartment": "compartment_70101", "id": "reaction_10600666", "reactome": "R-DDI-2197690", "name": "Detachment of WASP/WAVE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599991" ], "products": [ "species_10600037", "species_10599987" ], "modifiers": [], "additional_components": [ "O96626", "DDB_G0288319", "O96622", "DDB_G0277825", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "species_179838", "Q869Q3", "DDB_G0274519", "Q55FT9", "DDB_G0267956", "Q54X65", "DDB_G0279175", "Q6UK63", "DDB_G0287855", "P34144", "DDB_G0277869", "species_29438", "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54L54", "DDB_G0286893", "O96626", "DDB_G0288319", "O96622", "DDB_G0277825", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54L54", "DDB_G0286893", "species_29370", "species_179838", "Q869Q3", "DDB_G0274519", "Q55FT9", "DDB_G0267956", "Q54X65", "DDB_G0279175", "Q6UK63", "DDB_G0287855", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10599934": { "compartment": "compartment_70101", "id": "reaction_10599934", "reactome": "R-DDI-2029454", "name": "Autophosphorylation of PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599932", "species_113592" ], "products": [ "species_10583374", "species_29370", "species_10592613" ], "modifiers": [ [ "species_10590364", "catalyst" ] ], "additional_components": [ "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "P34144", "DDB_G0277869", "species_29438", "P34144", "DDB_G0277869", "species_29438", "Q869N2", "DDB_G0276459", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459" ] }, "reaction_10622818": { "compartment": "compartment_70101", "id": "reaction_10622818", "reactome": "R-DDI-8931974", "name": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583736", "species_71284" ], "products": [ "species_10622810", "species_71285" ], "modifiers": [ [ "species_10622815", "catalyst" ] ], "additional_components": [ "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "DDB_G0272708" ] }, "reaction_10622855": { "compartment": "compartment_70101", "id": "reaction_10622855", "reactome": "R-DDI-8932276", "name": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605038", "species_71284" ], "products": [ "species_10622843", "species_71285" ], "modifiers": [ [ "species_10622852", "catalyst" ] ], "additional_components": [ "DDB_G0288065", "DDB_G0288065", "Q54UI5", "DDB_G0288643", "Q54IN5", "DDB_G0288643" ] }, "reaction_10622829": { "compartment": "compartment_7660", "id": "reaction_10622829", "reactome": "R-DDI-8932221", "name": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10579254" ], "products": [ "species_77502", "species_10622821" ], "modifiers": [ [ "species_10622826", "catalyst" ] ], "additional_components": [ "DDB_G0269144", "DDB_G0269144", "DDB_G0288643" ] }, "reaction_10622877": { "compartment": "compartment_70101", "id": "reaction_10622877", "reactome": "R-DDI-8932413", "name": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583736", "species_71284" ], "products": [ "species_10622869", "species_71285" ], "modifiers": [ [ "species_10622874", "catalyst" ] ], "additional_components": [ "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "P0CT32", "DDB_G0269136", "P0CT31", "DDB_G0269134", "DDB_G0278427" ] }, "reaction_10588690": { "compartment": "compartment_70101", "id": "reaction_10588690", "reactome": "R-DDI-209845", "name": "CYP2R1 25-hydroxylates VD3 to 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_8963870", "species_29364" ], "products": [ "species_8963879", "species_29356", "species_29366" ], "modifiers": [ [ "species_10588687", "catalyst" ] ], "additional_components": [ "DDB_G0284535" ] }, "reaction_10586707": { "compartment": "compartment_70101", "id": "reaction_10586707", "reactome": "R-DDI-193800", "name": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193829", "species_29364" ], "products": [ "species_29366", "species_193843" ], "modifiers": [ [ "species_10586594", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586709": { "compartment": "compartment_70101", "id": "reaction_10586709", "reactome": "R-DDI-193816", "name": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_192194" ], "products": [ "species_70106", "species_193835", "species_73473" ], "modifiers": [ [ "species_10586611", "catalyst" ] ], "additional_components": [ "Q54XR1", "DDB_G0281487", "Q54TU9", "DDB_G0281487" ] }, "reaction_10586711": { "compartment": "compartment_70101", "id": "reaction_10586711", "reactome": "R-DDI-193821", "name": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_9617026" ], "products": [ "species_193829", "species_29366" ], "modifiers": [ [ "species_10586581", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586713": { "compartment": "compartment_70101", "id": "reaction_10586713", "reactome": "R-DDI-193824", "name": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193835", "species_29364" ], "products": [ "species_29366", "species_193830" ], "modifiers": [ [ "species_10586581", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586715": { "compartment": "compartment_70101", "id": "reaction_10586715", "reactome": "R-DDI-193841", "name": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193830" ], "products": [ "species_29366", "species_193842" ], "modifiers": [ [ "species_10586594", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586705": { "compartment": "compartment_70101", "id": "reaction_10586705", "reactome": "R-DDI-193789", "name": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192189", "species_29360" ], "products": [ "species_193724", "species_70106", "species_73473" ], "modifiers": [ [ "species_10586611", "catalyst" ] ], "additional_components": [ "Q54XR1", "DDB_G0281487", "Q54TU9", "DDB_G0281487" ] }, "reaction_10586697": { "compartment": "compartment_70101", "id": "reaction_10586697", "reactome": "R-DDI-193746", "name": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193724", "species_70106", "species_29364" ], "products": [ "species_29366", "species_193760" ], "modifiers": [ [ "species_10586581", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586699": { "compartment": "compartment_70101", "id": "reaction_10586699", "reactome": "R-DDI-193755", "name": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193745" ], "products": [ "species_193707", "species_29366" ], "modifiers": [ [ "species_10586581", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586701": { "compartment": "compartment_70101", "id": "reaction_10586701", "reactome": "R-DDI-193758", "name": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193760" ], "products": [ "species_29366", "species_213285" ], "modifiers": [ [ "species_10586594", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586703": { "compartment": "compartment_70101", "id": "reaction_10586703", "reactome": "R-DDI-193781", "name": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193707", "species_29364" ], "products": [ "species_29366", "species_193728" ], "modifiers": [ [ "species_10586594", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586688": { "compartment": "compartment_17951", "id": "reaction_10586688", "reactome": "R-DDI-193369", "name": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_193442" ], "products": [ "species_113575", "species_193459" ], "modifiers": [ [ "species_10586633", "catalyst" ] ], "additional_components": [ "species_113596", "Q54GQ6", "DDB_G0289993" ] }, "reaction_10586691": { "compartment": "compartment_17951", "id": "reaction_10586691", "reactome": "R-DDI-193455", "name": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193422", "species_192307" ], "products": [ "species_193465", "species_192305", "species_192339" ], "modifiers": [ [ "species_10586623", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10586626": { "compartment": "compartment_17951", "id": "reaction_10586626", "reactome": "R-DDI-192331", "name": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_192342" ], "products": [ "species_193422" ], "modifiers": [ [ "species_10586623", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10586597": { "compartment": "compartment_70101", "id": "reaction_10586597", "reactome": "R-DDI-192036", "name": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_192064" ], "products": [ "species_29366", "species_192087" ], "modifiers": [ [ "species_10586594", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586693": { "compartment": "compartment_17951", "id": "reaction_10586693", "reactome": "R-DDI-193508", "name": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193732", "species_192307" ], "products": [ "species_193465", "species_193403", "species_192305" ], "modifiers": [ [ "species_10586623", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10586599": { "compartment": "compartment_70101", "id": "reaction_10586599", "reactome": "R-DDI-192067", "name": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_192195" ], "products": [ "species_29366", "species_192064" ], "modifiers": [ [ "species_10586581", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586695": { "compartment": "compartment_17951", "id": "reaction_10586695", "reactome": "R-DDI-193535", "name": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_193459" ], "products": [ "species_193732" ], "modifiers": [ [ "species_10586623", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10586614": { "compartment": "compartment_70101", "id": "reaction_10586614", "reactome": "R-DDI-192097", "name": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_192114" ], "products": [ "species_70106", "species_192136", "species_73473" ], "modifiers": [ [ "species_10586611", "catalyst" ] ], "additional_components": [ "Q54XR1", "DDB_G0281487", "Q54TU9", "DDB_G0281487" ] }, "reaction_10586584": { "compartment": "compartment_70101", "id": "reaction_10586584", "reactome": "R-DDI-192033", "name": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_192136", "species_29364" ], "products": [ "species_191980", "species_29366" ], "modifiers": [ [ "species_10586581", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586616": { "compartment": "compartment_70101", "id": "reaction_10586616", "reactome": "R-DDI-192160", "name": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191980", "species_70106", "species_29364" ], "products": [ "species_192030", "species_29366" ], "modifiers": [ [ "species_10586594", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586636": { "compartment": "compartment_17951", "id": "reaction_10586636", "reactome": "R-DDI-192335", "name": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_192316" ], "products": [ "species_113575", "species_192342" ], "modifiers": [ [ "species_10586633", "catalyst" ] ], "additional_components": [ "species_113596", "Q54GQ6", "DDB_G0289993" ] }, "reaction_10586686": { "compartment": "compartment_876", "id": "reaction_10586686", "reactome": "R-DDI-193362", "name": "ABCB11 transports bile salts from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_193416", "species_113592" ], "products": [ "species_29372", "species_29370", "species_193479" ], "modifiers": [ [ "species_10586683", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:36274", "CHEBI:16525", "CHEBI:28865", "CHEBI:17687", "CHEBI:28865", "CHEBI:36274", "CHEBI:9407", "Q54BT3", "DDB_G0293438", "Q8T9W4", "DDB_G0291714" ] }, "reaction_10620155": { "compartment": "compartment_70101", "id": "reaction_10620155", "reactome": "R-DDI-8867667", "name": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8868399" ], "products": [ "species_8868400" ], "modifiers": [ [ "species_10620152", "catalyst" ] ], "additional_components": [ "Q54QP6", "DDB_G0283709", "Q8MPQ7", "DDB_G0280053", "Q86HL8", "DDB_G0274517", "Q54RM1", "DDB_G0283035", "Q54EF5", "DDB_G0291562", "Q86HV4", "DDB_G0276427", "Q55CR2", "DDB_G0269940", "Q55CR3", "DDB_G0269938", "Q54NM4", "DDB_G0285141", "Q86KG4", "DDB_G0272498", "Q54ID7", "DDB_G0288817" ] }, "reaction_10586559": { "compartment": "compartment_70101", "id": "reaction_10586559", "reactome": "R-DDI-191983", "name": "Cholesterol is hydroxylated to 25-hydroxycholesterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176478", "species_70106", "species_29368", "species_29364" ], "products": [ "species_29356", "species_192148", "species_29366" ], "modifiers": [ [ "species_10586556", "catalyst" ] ], "additional_components": [ "species_71067", "Q55D52", "DDB_G0279611", "Q55D54", "DDB_G0279611", "Q54WK0", "DDB_G0279611" ] }, "reaction_10586717": { "compartment": "compartment_70101", "id": "reaction_10586717", "reactome": "R-DDI-193961", "name": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196366" ], "products": [ "species_193092" ], "modifiers": [ [ "species_10586654", "catalyst" ] ], "additional_components": [ "Q54XR1", "DDB_G0281487", "Q54TU9", "DDB_G0281487" ] }, "reaction_10586780": { "compartment": "compartment_70101", "id": "reaction_10586780", "reactome": "R-DDI-196372", "name": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193124", "species_29360" ], "products": [ "species_196366", "species_70106", "species_73473" ], "modifiers": [ [ "species_10586654", "catalyst" ] ], "additional_components": [ "Q54XR1", "DDB_G0281487", "Q54TU9", "DDB_G0281487" ] }, "reaction_10586657": { "compartment": "compartment_70101", "id": "reaction_10586657", "reactome": "R-DDI-193052", "name": "Pregn-5-ene-3,20-dione isomerizes to progesterone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196344" ], "products": [ "species_193055" ], "modifiers": [ [ "species_10586654", "catalyst" ] ], "additional_components": [ "Q54XR1", "DDB_G0281487", "Q54TU9", "DDB_G0281487" ] }, "reaction_10586778": { "compartment": "compartment_70101", "id": "reaction_10586778", "reactome": "R-DDI-196350", "name": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193103", "species_29360" ], "products": [ "species_70106", "species_196344", "species_73473" ], "modifiers": [ [ "species_10586654", "catalyst" ] ], "additional_components": [ "Q54XR1", "DDB_G0281487", "Q54TU9", "DDB_G0281487" ] }, "reaction_10586775": { "compartment": "compartment_70101", "id": "reaction_10586775", "reactome": "R-DDI-196060", "name": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196095", "species_70106", "species_29364" ], "products": [ "species_29366", "species_196066" ], "modifiers": [ [ "species_10586772", "catalyst" ] ], "additional_components": [ "Q55FL3", "DDB_G0268058", "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562" ] }, "reaction_10627409": { "compartment": "compartment_70101", "id": "reaction_10627409", "reactome": "R-DDI-9705714", "name": "SRD5A3 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193057" ], "products": [ "species_469662", "species_29366" ], "modifiers": [ [ "species_10603671", "catalyst" ] ], "additional_components": [ "DDB_G0284423" ] }, "reaction_10586669": { "compartment": "compartment_70101", "id": "reaction_10586669", "reactome": "R-DDI-193064", "name": "HSD17B3-like proteins reducde ANDST to TEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193079", "species_29364" ], "products": [ "species_29366", "species_193057" ], "modifiers": [ [ "species_10586666", "catalyst" ] ], "additional_components": [ "Q869Y3", "DDB_G0275049" ] }, "reaction_10586671": { "compartment": "compartment_70101", "id": "reaction_10586671", "reactome": "R-DDI-193073", "name": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176626", "species_29360" ], "products": [ "species_70106", "species_193079", "species_73473" ], "modifiers": [ [ "species_10586654", "catalyst" ] ], "additional_components": [ "Q54XR1", "DDB_G0281487", "Q54TU9", "DDB_G0281487" ] }, "reaction_10594144": { "compartment": "compartment_70101", "id": "reaction_10594144", "reactome": "R-DDI-804969", "name": "HSD17B1 hydrogenates E1 to EST17b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193066", "species_29364" ], "products": [ "species_193132", "species_29366" ], "modifiers": [ [ "species_10594141", "catalyst" ] ], "additional_components": [ "Q556S5", "DDB_G0273855" ] }, "reaction_10612176": { "compartment": "compartment_5460", "id": "reaction_10612176", "reactome": "R-DDI-5696822", "name": "AKR1B15 reduces EST17b to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_5696835" ], "products": [ "species_113529", "species_5696848", "species_113600" ], "modifiers": [ [ "species_10612173", "catalyst" ] ], "additional_components": [ "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058", "Q6IMN8", "DDB_G0293850" ] }, "reaction_10586465": { "compartment": "compartment_70101", "id": "reaction_10586465", "reactome": "R-DDI-191402", "name": "Reduction of presqualene diphosphate to form squalene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_191265" ], "products": [ "species_111294", "species_191269", "species_29366" ], "modifiers": [ [ "species_10586462", "catalyst" ] ], "additional_components": [ "species_29926", "Q54DR1", "DDB_G0292072" ] }, "reaction_10586752": { "compartment": "compartment_70101", "id": "reaction_10586752", "reactome": "R-DDI-194718", "name": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194657", "species_29360" ], "products": [ "species_70106", "species_113528", "species_194661", "species_73473" ], "modifiers": [ [ "species_10586724", "catalyst" ] ], "additional_components": [ "DDB_G0281487" ] }, "reaction_10586467": { "compartment": "compartment_70101", "id": "reaction_10586467", "reactome": "R-DDI-191405", "name": "Two FPP molecules dimerize to form presqualene diphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191385" ], "products": [ "species_111294", "species_191265" ], "modifiers": [ [ "species_10586462", "catalyst" ] ], "additional_components": [ "species_29926", "Q54DR1", "DDB_G0292072" ] }, "reaction_10586435": { "compartment": "compartment_70101", "id": "reaction_10586435", "reactome": "R-DDI-191366", "name": "Squalene 2,3-epoxide cyclizes, forming lanosterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191309" ], "products": [ "species_194634" ], "modifiers": [ [ "species_10586432", "catalyst" ] ], "additional_components": [ "DDB_G0269226" ] }, "reaction_10586722": { "compartment": "compartment_70101", "id": "reaction_10586722", "reactome": "R-DDI-194641", "name": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_194644", "species_29364" ], "products": [ "species_194735", "species_29356", "species_29366" ], "modifiers": [ [ "species_10586719", "catalyst" ] ], "additional_components": [ "DDB_G0279611" ] }, "reaction_10586727": { "compartment": "compartment_70101", "id": "reaction_10586727", "reactome": "R-DDI-194642", "name": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194735", "species_29360" ], "products": [ "species_70106", "species_113528", "species_194667", "species_73473" ], "modifiers": [ [ "species_10586724", "catalyst" ] ], "additional_components": [ "DDB_G0281487" ] }, "reaction_10586409": { "compartment": "compartment_70101", "id": "reaction_10586409", "reactome": "R-DDI-191303", "name": "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191409", "species_191362" ], "products": [ "species_111294", "species_191385" ], "modifiers": [ [ "species_10586406", "catalyst" ] ], "additional_components": [ "Q54BK1", "DDB_G0293588", "species_29926", "Q9NH03", "DDB_G0278735" ] }, "reaction_10586729": { "compartment": "compartment_70101", "id": "reaction_10586729", "reactome": "R-DDI-194669", "name": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_194723" ], "products": [ "species_29356", "species_29366", "species_194657" ], "modifiers": [ [ "species_10586719", "catalyst" ] ], "additional_components": [ "DDB_G0279611" ] }, "reaction_10586445": { "compartment": "compartment_70101", "id": "reaction_10586445", "reactome": "R-DDI-191380", "name": "Mevalonate is phosphorylated to mevalonate-5-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191424" ], "products": [ "species_29370", "species_191296" ], "modifiers": [ [ "species_10586442", "catalyst" ] ], "additional_components": [ "Q86AG7", "DDB_G0272018" ] }, "reaction_10586477": { "compartment": "compartment_70101", "id": "reaction_10586477", "reactome": "R-DDI-191414", "name": "MVD decarboxylates MVA5PP to IPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191403" ], "products": [ "species_29372", "species_29370", "species_113528", "species_191362" ], "modifiers": [ [ "species_10586474", "catalyst" ] ], "additional_components": [ "Q54YQ9", "DDB_G0278607" ] }, "reaction_10586412": { "compartment": "compartment_70101", "id": "reaction_10586412", "reactome": "R-DDI-191322", "name": "Addition of isopentenyl pyrophosphate to DMAPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191324", "species_191362" ], "products": [ "species_111294", "species_191409" ], "modifiers": [ [ "species_10586406", "catalyst" ] ], "additional_components": [ "Q54BK1", "DDB_G0293588", "species_29926", "Q9NH03", "DDB_G0278735" ] }, "reaction_10623693": { "compartment": "compartment_70101", "id": "reaction_10623693", "reactome": "R-DDI-8952137", "name": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_191265" ], "products": [ "species_8952135", "species_29372" ], "modifiers": [ [ "species_10623690", "catalyst" ] ], "additional_components": [ "DDB_G0281069" ] }, "reaction_10586417": { "compartment": "compartment_70101", "id": "reaction_10586417", "reactome": "R-DDI-191323", "name": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191293", "species_76183" ], "products": [ "species_29356", "species_191374", "species_76194" ], "modifiers": [ [ "species_10586414", "catalyst" ] ], "additional_components": [ "DDB_G0274871" ] }, "reaction_10586737": { "compartment": "compartment_13231", "id": "reaction_10586737", "reactome": "R-DDI-194674", "name": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194681", "species_194725", "species_194688" ], "products": [ "species_194668", "species_194704" ], "modifiers": [ [ "species_10586734", "catalyst" ] ], "additional_components": [ "DDB_G0267448" ] }, "reaction_10586386": { "compartment": "compartment_70101", "id": "reaction_10586386", "reactome": "R-DDI-191299", "name": "Squalene is oxidized to its epoxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_191269", "species_29364" ], "products": [ "species_191309", "species_29356", "species_29366" ], "modifiers": [ [ "species_10586383", "catalyst" ] ], "additional_components": [ "species_113596", "Q54BK7", "DDB_G0293584" ] }, "reaction_10586455": { "compartment": "compartment_70101", "id": "reaction_10586455", "reactome": "R-DDI-191382", "name": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362" ], "products": [ "species_191324" ], "modifiers": [ [ "species_10586452", "catalyst" ] ], "additional_components": [ "Q9NH02", "DDB_G0290011", "species_29926" ] }, "reaction_10586745": { "compartment": "compartment_70101", "id": "reaction_10586745", "reactome": "R-DDI-194678", "name": "CYP51A1 demethylates LNSOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_194634", "species_29364" ], "products": [ "species_29356", "species_29366", "species_194644", "species_29460" ], "modifiers": [ [ "species_10586742", "catalyst" ] ], "additional_components": [ "DDB_G0279403" ] }, "reaction_10586427": { "compartment": "compartment_70101", "id": "reaction_10586427", "reactome": "R-DDI-191352", "name": "HMGCR dimer reduces bHMG-CoA to MVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191374", "species_70106", "species_29364" ], "products": [ "species_29366", "species_76194", "species_191424" ], "modifiers": [ [ "species_10586424", "catalyst" ] ], "additional_components": [ "P34135", "DDB_G0269142" ] }, "reaction_10616679": { "compartment": "compartment_12045", "id": "reaction_10616679", "reactome": "R-DDI-6807052", "name": "EBP isomerizes ZYMSTNL to LTHSOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6807048" ], "products": [ "species_6807054" ], "modifiers": [ [ "species_10586757", "catalyst" ] ], "additional_components": [ "DDB_G0269414" ] }, "reaction_10616681": { "compartment": "compartment_12045", "id": "reaction_10616681", "reactome": "R-DDI-6807055", "name": "DHCR7 reduces 7-dehydroCHOL to CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_6807057", "species_29364" ], "products": [ "species_193384", "species_29366" ], "modifiers": [ [ "species_10586785", "catalyst" ] ], "additional_components": [ "DDB_G0284407" ] }, "reaction_10604925": { "compartment": "compartment_17957", "id": "reaction_10604925", "reactome": "R-DDI-5250531", "name": "ARV1 transports CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193384" ], "products": [ "species_171095" ], "modifiers": [ [ "species_10604922", "catalyst" ] ], "additional_components": [ "DDB_G0290221" ] }, "reaction_10586750": { "compartment": "compartment_70101", "id": "reaction_10586750", "reactome": "R-DDI-194698", "name": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_194644", "species_29364" ], "products": [ "species_194633", "species_29366" ], "modifiers": [ [ "species_10586747", "catalyst" ] ], "additional_components": [ "DDB_G0267448" ] }, "reaction_10580109": { "compartment": "compartment_70101", "id": "reaction_10580109", "reactome": "R-DDI-72670", "name": "Formation of eIF2:GDP:eIF2B intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580105", "species_10580049" ], "products": [ "species_10580107" ], "modifiers": [], "additional_components": [ "Q54I81", "DDB_G0288961", "Q54RF3", "DDB_G0283163", "Q54FQ8", "DDB_G0290693", "Q54EY2", "DDB_G0291271", "Q54FM3", "DDB_G0290759", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29420", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "Q54I81", "DDB_G0288961", "Q54RF3", "DDB_G0283163", "Q54FQ8", "DDB_G0290693", "Q54EY2", "DDB_G0291271", "Q54FM3", "DDB_G0290759", "species_29420" ] }, "reaction_10580399": { "compartment": "compartment_70101", "id": "reaction_10580399", "reactome": "R-DDI-72722", "name": "eIF2 activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10580107" ], "products": [ "species_29420", "species_10580105", "species_10580004" ], "modifiers": [ [ "species_10580105", "catalyst" ] ], "additional_components": [ "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "Q54I81", "DDB_G0288961", "Q54RF3", "DDB_G0283163", "Q54FQ8", "DDB_G0290693", "Q54EY2", "DDB_G0291271", "Q54FM3", "DDB_G0290759", "species_29420", "Q54I81", "DDB_G0288961", "Q54RF3", "DDB_G0283163", "Q54FQ8", "DDB_G0290693", "Q54EY2", "DDB_G0291271", "Q54FM3", "DDB_G0290759", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54I81", "DDB_G0288961", "Q54RF3", "DDB_G0283163", "Q54FQ8", "DDB_G0290693", "Q54EY2", "DDB_G0291271", "Q54FM3", "DDB_G0290759" ] }, "reaction_10616599": { "compartment": "compartment_7660", "id": "reaction_10616599", "reactome": "R-DDI-6805061", "name": "CK2 binds FACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583211", "species_10616595" ], "products": [ "species_10616597" ], "modifiers": [], "additional_components": [ "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q54PF1", "DDB_G0284601", "Q02720", "DDB_G0276885", "Q54LR6", "DDB_G0286481", "Q54PF1", "DDB_G0284601", "Q02720", "DDB_G0276885", "Q54LR6", "DDB_G0286481", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677" ] }, "reaction_10603956": { "compartment": "compartment_7660", "id": "reaction_10603956", "reactome": "R-DDI-4570489", "name": "SUMOylation of NOP58 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601786", "species_10603928" ], "products": [ "species_10601725", "species_10603953" ], "modifiers": [ [ "species_10601786", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q54SX2", "DDB_G0282161", "DDB_G0268098", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "DDB_G0268098", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q54SX2", "DDB_G0282161" ] }, "reaction_10603944": { "compartment": "compartment_7660", "id": "reaction_10603944", "reactome": "R-DDI-4570467", "name": "SUMOylation of NOP58 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10603928" ], "products": [ "species_10601725", "species_10603942" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0268098", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q55FI4", "DDB_G0268098", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10583553": { "compartment": "compartment_114521", "id": "reaction_10583553", "reactome": "R-DDI-139854", "name": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_139827" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10583550", "catalyst" ] ], "additional_components": [ "species_114520", "species_74112", "Q9NA13", "DDB_G0292564" ] }, "reaction_10598400": { "compartment": "compartment_161320", "id": "reaction_10598400", "reactome": "R-DDI-1605736", "name": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605716", "species_1605715" ], "products": [ "species_1605637", "species_1605601" ], "modifiers": [ [ "species_10598397", "catalyst" ] ], "additional_components": [ "Q54EG4", "DDB_G0291524", "Q55B10", "DDB_G0271490" ] }, "reaction_10598437": { "compartment": "compartment_876", "id": "reaction_10598437", "reactome": "R-DDI-1606583", "name": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429807" ], "products": [ "species_1606609", "species_1861754" ], "modifiers": [ [ "species_10598434", "catalyst" ] ], "additional_components": [] }, "reaction_10598343": { "compartment": "compartment_161320", "id": "reaction_10598343", "reactome": "R-DDI-1605624", "name": "Beta-galactosidase hydrolyses GM1 to GM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605677" ], "products": [ "species_1605637", "species_1605610" ], "modifiers": [ [ "species_10598338", "catalyst" ] ], "additional_components": [ "DDB_G0290217" ] }, "reaction_10598425": { "compartment": "compartment_876", "id": "reaction_10598425", "reactome": "R-DDI-1606273", "name": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429776" ], "products": [ "species_429807", "species_1610735" ], "modifiers": [ [ "species_10598422", "catalyst" ] ], "additional_components": [ "Q86IG2", "DDB_G0288017", "Q1ZXD9", "DDB_G0288017", "species_29926" ] }, "reaction_10598408": { "compartment": "compartment_161320", "id": "reaction_10598408", "reactome": "R-DDI-1605797", "name": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605713" ], "products": [ "species_1605750", "species_1605673" ], "modifiers": [ [ "species_10598405", "catalyst" ] ], "additional_components": [ "DDB_G0293210" ] }, "reaction_10598427": { "compartment": "compartment_161320", "id": "reaction_10598427", "reactome": "R-DDI-1606312", "name": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605601" ], "products": [ "species_1605637", "species_1605592" ], "modifiers": [ [ "species_10598338", "catalyst" ] ], "additional_components": [ "DDB_G0290217" ] }, "reaction_10599629": { "compartment": "compartment_876", "id": "reaction_10599629", "reactome": "R-DDI-1861788", "name": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1861782" ], "products": [ "species_429807", "species_70113" ], "modifiers": [ [ "species_10599626", "catalyst" ] ], "additional_components": [ "DDB_G0292446" ] }, "reaction_10598508": { "compartment": "compartment_876", "id": "reaction_10598508", "reactome": "R-DDI-1640164", "name": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429776" ], "products": [ "species_429807", "species_1610735" ], "modifiers": [ [ "species_10598505", "catalyst" ] ], "additional_components": [ "DDB_G0285897" ] }, "reaction_10598383": { "compartment": "compartment_161320", "id": "reaction_10598383", "reactome": "R-DDI-1605632", "name": "Both hexosaminidase A and B can cleave GalNAc from globoside", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605608" ], "products": [ "species_1605716", "species_1605658" ], "modifiers": [ [ "species_10598380", "catalyst" ] ], "additional_components": [ "Q54K55", "DDB_G0287597", "Q54SC9", "DDB_G0282539", "Q54K56", "DDB_G0287659", "Q54MU9", "DDB_G0285647", "P13723", "DDB_G0287033" ] }, "reaction_10605541": { "compartment": "compartment_876", "id": "reaction_10605541", "reactome": "R-DDI-5617178", "name": "ATP2B4 binds to NOS1, inhibiting it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590744", "species_10590737" ], "products": [ "species_10605539" ], "modifiers": [], "additional_components": [ "DDB_G0269912", "P54678", "DDB_G0277861", "Q54HG6", "DDB_G0289473", "Q54PE8", "DDB_G0289473", "P54678", "DDB_G0277861", "Q54HG6", "DDB_G0289473", "Q54PE8", "DDB_G0289473", "Q55CT1", "DDB_G0269912" ] }, "reaction_10595189": { "compartment": "compartment_876", "id": "reaction_10595189", "reactome": "R-DDI-936942", "name": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10595116", "species_10577037" ], "products": [ "species_10595186" ], "modifiers": [ [ "species_10595116", "catalyst" ] ], "additional_components": [ "Q54F79", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55A66", "DDB_G0293202", "P11467", "DDB_G0290961", "Q55GA0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54FD5", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "P11467", "DDB_G0290961", "Q86L54", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "Q54F79", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55A66", "DDB_G0293202", "P11467", "DDB_G0290961", "Q55GA0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54LU8", "DDB_G0286465" ] }, "reaction_10595191": { "compartment": "compartment_70101", "id": "reaction_10595191", "reactome": "R-DDI-936963", "name": "IRAK2 induces TRAF6 oligomerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10595114", "species_10584497" ], "products": [ "species_10595116" ], "modifiers": [], "additional_components": [ "Q54F79", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55A66", "DDB_G0293202", "P11467", "DDB_G0290961", "Q55GA0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55A66", "DDB_G0293202", "P11467", "DDB_G0290961", "Q55GA0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54LU8", "DDB_G0286465" ] }, "reaction_10595194": { "compartment": "compartment_70101", "id": "reaction_10595194", "reactome": "R-DDI-936986", "name": "Activated TRAF6 synthesizes unanchored polyubiquitin chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037" ], "products": [ "species_10584754" ], "modifiers": [ [ "species_10595186", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54FD5", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "P11467", "DDB_G0290961", "Q86L54", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54LU8", "DDB_G0286465" ] }, "reaction_10595760": { "compartment": "compartment_74700", "id": "reaction_10595760", "reactome": "R-DDI-975147", "name": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10595757", "species_10577037" ], "products": [ "species_10593152" ], "modifiers": [ [ "species_10595757", "catalyst" ] ], "additional_components": [ "Q55A66", "DDB_G0293202", "P11467", "DDB_G0290961", "Q55GA0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54C11", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "P11467", "DDB_G0290961", "Q86L54", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "Q55A66", "DDB_G0293202", "P11467", "DDB_G0290961", "Q55GA0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q54LU8", "DDB_G0286465" ] }, "reaction_10595762": { "compartment": "compartment_74700", "id": "reaction_10595762", "reactome": "R-DDI-975185", "name": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10595755", "species_10584497" ], "products": [ "species_10595757" ], "modifiers": [], "additional_components": [ "Q55A66", "DDB_G0293202", "P11467", "DDB_G0290961", "Q55GA0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q55A66", "DDB_G0293202", "P11467", "DDB_G0290961", "Q55GA0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q54LU8", "DDB_G0286465" ] }, "reaction_10584367": { "compartment": "compartment_984", "id": "reaction_10584367", "reactome": "R-DDI-166015", "name": "Association of LBP with LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584361", "species_166005" ], "products": [ "species_10584363" ], "modifiers": [ [ "species_10584365", "inhibitor" ] ], "additional_components": [ "Q54JE8", "DDB_G0288097", "Q55BA2", "DDB_G0271242", "Q54JE7", "DDB_G0288097", "species_166005", "Q54JE8", "DDB_G0288097", "Q55BA2", "DDB_G0271242", "Q54JE7", "DDB_G0288097", "DDB_G0271242" ] }, "reaction_10616640": { "compartment": "compartment_984", "id": "reaction_10616640", "reactome": "R-DDI-6805981", "name": "HMGB1 release from cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589181" ], "products": [ "species_10616549" ], "modifiers": [], "additional_components": [ "DDB_G0270260", "DDB_G0270260" ] }, "reaction_10616553": { "compartment": "compartment_984", "id": "reaction_10616553", "reactome": "R-DDI-6804099", "name": "HMGB1 binds LTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_181015", "species_10616549" ], "products": [ "species_10616551" ], "modifiers": [], "additional_components": [ "DDB_G0270260", "Q55C24", "DDB_G0270260", "species_181015" ] }, "reaction_10620682": { "compartment": "compartment_984", "id": "reaction_10620682", "reactome": "R-DDI-8869683", "name": "oxPL binds LBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584361", "species_2186967" ], "products": [ "species_10620680" ], "modifiers": [], "additional_components": [ "Q54JE8", "DDB_G0288097", "Q55BA2", "DDB_G0271242", "Q54JE7", "DDB_G0288097", "species_2186967", "Q54JE8", "DDB_G0288097", "Q55BA2", "DDB_G0271242", "Q54JE7", "DDB_G0288097" ] }, "reaction_10616557": { "compartment": "compartment_984", "id": "reaction_10616557", "reactome": "R-DDI-6804100", "name": "HMGB1 binds LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_166005", "species_10616549" ], "products": [ "species_10616555" ], "modifiers": [], "additional_components": [ "DDB_G0270260", "Q55C24", "DDB_G0270260", "species_166005" ] }, "reaction_10625430": { "compartment": "compartment_17906", "id": "reaction_10625430", "reactome": "R-DDI-9018815", "name": "RHOT1 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625411", "species_10625426" ], "products": [ "species_10625428" ], "modifiers": [], "additional_components": [ "Q55G45", "DDB_G0267830", "species_29438", "Q9U1M8", "DDB_G0274455", "P54696", "DDB_G0289447", "Q9TW28", "DDB_G0292262", "P54697", "DDB_G0272112", "Q9U1M8", "DDB_G0274455", "P54696", "DDB_G0289447", "Q9TW28", "DDB_G0292262", "P54697", "DDB_G0272112", "Q55G45", "DDB_G0267830", "species_29438" ] }, "reaction_10625416": { "compartment": "compartment_70101", "id": "reaction_10625416", "reactome": "R-DDI-9018814", "name": "RHOT1 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10625411" ], "products": [ "species_29372", "species_10625413" ], "modifiers": [ [ "species_10625411", "catalyst" ] ], "additional_components": [ "Q55G45", "DDB_G0267830", "species_29438", "Q55G45", "DDB_G0267830", "species_29420", "Q55G45", "DDB_G0267830", "species_29438" ] }, "reaction_10607623": { "compartment": "compartment_70101", "id": "reaction_10607623", "reactome": "R-DDI-5676966", "name": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5687536", "species_71284" ], "products": [ "species_5687529", "species_71285" ], "modifiers": [ [ "species_10607620", "catalyst" ] ], "additional_components": [ "DDB_G0280979" ] }, "reaction_10627360": { "compartment": "compartment_7660", "id": "reaction_10627360", "reactome": "R-DDI-9686969", "name": "APC/C:Cdh1 polyubiquitinates SKP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627357", "species_10576865" ], "products": [ "species_10585955" ], "modifiers": [ [ "species_10627357", "catalyst" ] ], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "Q54FX2", "DDB_G0290551", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "Q54FX2", "DDB_G0290551", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "Q54FX2", "DDB_G0290551" ] }, "reaction_10585442": { "compartment": "compartment_70101", "id": "reaction_10585442", "reactome": "R-DDI-174195", "name": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585356", "species_10577037" ], "products": [ "species_10585371" ], "modifiers": [ [ "species_10585356", "catalyst" ] ], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54KM3", "DDB_G0287259", "Q86HN7", "DDB_G0274503", "Q54WX4", "DDB_G0279343", "Q54MZ3", "DDB_G0285601", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54KM3", "DDB_G0287259", "Q86HN7", "DDB_G0274503", "Q54WX4", "DDB_G0279343", "Q54MZ3", "DDB_G0285601", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54KM3", "DDB_G0287259", "Q86HN7", "DDB_G0274503", "Q54WX4", "DDB_G0279343", "Q54MZ3", "DDB_G0285601" ] }, "reaction_10585957": { "compartment": "compartment_7660", "id": "reaction_10585957", "reactome": "R-DDI-188191", "name": "APC/C:Cdh1-mediated degradation of Skp2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585955" ], "products": [ "species_10577547", "species_10585336", "species_10576865" ], "modifiers": [ [ "species_10585327", "catalyst" ] ], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "Q54FX2", "DDB_G0290551", "DDB_G0290551", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q27563", "DDB_G0267408", "P02889", "DDB_G0272564", "P34119", "DDB_G0280969", "Q552Y8", "DDB_G0275753", "Q55G04", "DDB_G0268538", "Q967U1", "DDB_G0285099", "Q54XM7", "DDB_G0278847", "P34120", "DDB_G0272831", "Q86A21", "DDB_G0272969", "Q54S82", "DDB_G0282617", "Q54QR2", "DDB_G0283679", "Q55DY7", "DDB_G0269472", "Q55D66", "DDB_G0269772", "Q556Q0", "DDB_G0273163", "Q54BC8", "DDB_G0293784", "Q55GJ6", "DDB_G0267390", "Q55BV5", "DDB_G0270784", "Q86JA1", "DDB_G0276917", "Q54PN7", "DDB_G0284415", "P34123", "DDB_G0289003", "P34124", "DDB_G0292382", "Q54PJ1", "DDB_G0284517", "Q54JM5", "DDB_G0287953", "Q54HW1", "DDB_G0289189", "Q54UB5", "DDB_G0281315", "Q54UJ0", "DDB_G0281051", "Q54NQ0", "DDB_G0285105", "Q54BC6", "DDB_G0293752", "Q1ZXD3", "DDB_G0288621", "Q553E0", "DDB_G0275775", "Q86IJ1", "DDB_G0272566", "Q559F4", "DDB_G0272951", "Q27562", "DDB_G0282363", "Q55C75", "DDB_G0270188", "Q54DM7", "DDB_G0292122", "Q54WI8", "DDB_G0279633" ] }, "reaction_10585373": { "compartment": "compartment_70101", "id": "reaction_10585373", "reactome": "R-DDI-174105", "name": "Degradation of multiubiquitinated cell cycle proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585371" ], "products": [ "species_10577037", "species_10577384" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54KM3", "DDB_G0287259", "Q86HN7", "DDB_G0274503", "Q54WX4", "DDB_G0279343", "Q54MZ3", "DDB_G0285601", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54KM3", "DDB_G0287259", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10585358": { "compartment": "compartment_70101", "id": "reaction_10585358", "reactome": "R-DDI-174088", "name": "Association of cell cycle proteins with the APC/C:Cdh1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585354", "species_10577384" ], "products": [ "species_10585356" ], "modifiers": [], "additional_components": [ "Q86HN7", "DDB_G0274503", "Q54XS6", "DDB_G0278775", "Q54WX4", "DDB_G0279343", "Q54MZ3", "DDB_G0285601", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54KM3", "DDB_G0287259", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54KM3", "DDB_G0287259", "Q86HN7", "DDB_G0274503", "Q54WX4", "DDB_G0279343", "Q54MZ3", "DDB_G0285601" ] }, "reaction_10585448": { "compartment": "compartment_70101", "id": "reaction_10585448", "reactome": "R-DDI-174203", "name": "SCF-mediated degradation of Emi1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585434" ], "products": [ "species_10577037", "species_10585446", "species_10585428" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q7KWS8", "DDB_G0276283", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54KM3", "DDB_G0287259", "Q54MZ3", "DDB_G0285601", "Q7KWS8", "DDB_G0276283", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10585437": { "compartment": "compartment_70101", "id": "reaction_10585437", "reactome": "R-DDI-174159", "name": "Ubiquitination of Emi1 by SCF-beta-TrCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10585432" ], "products": [ "species_10585434" ], "modifiers": [ [ "species_10585428", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q7KWS8", "DDB_G0276283", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q7KWS8", "DDB_G0276283", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q7KWS8", "DDB_G0276283", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972" ] }, "reaction_10585961": { "compartment": "compartment_7660", "id": "reaction_10585961", "reactome": "R-DDI-188371", "name": "Association of Cyclin A:Cdk2 with Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585336", "species_10576705" ], "products": [ "species_10585338" ], "modifiers": [], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "P34112", "DDB_G0272813", "P34112", "DDB_G0272813", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259" ] }, "reaction_10583654": { "compartment": "compartment_70101", "id": "reaction_10583654", "reactome": "R-DDI-141423", "name": "Binding of the MCC complex to the APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583650", "species_10577377" ], "products": [ "species_10583652" ], "modifiers": [], "additional_components": [ "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601" ] }, "reaction_10583660": { "compartment": "compartment_70101", "id": "reaction_10583660", "reactome": "R-DDI-141437", "name": "Formation of the MCC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583643", "species_10583638", "species_10583648", "species_10583633" ], "products": [ "species_10583650" ], "modifiers": [], "additional_components": [ "DDB_G0285601", "DDB_G0292134", "DDB_G0273201", "DDB_G0292676", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601" ] }, "reaction_10583658": { "compartment": "compartment_70101", "id": "reaction_10583658", "reactome": "R-DDI-141429", "name": "Inactivation of APC/C via CDC20 sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583643", "species_10583648" ], "products": [ "species_10583656" ], "modifiers": [], "additional_components": [ "DDB_G0285601", "DDB_G0273201", "Q556Y9", "DDB_G0273201", "Q54MZ3", "DDB_G0285601" ] }, "reaction_10585343": { "compartment": "compartment_7660", "id": "reaction_10585343", "reactome": "R-DDI-174079", "name": "Phosphorylation of Cdh1 by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10585338" ], "products": [ "species_113582", "species_10585340" ], "modifiers": [ [ "species_10585338", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "P34112", "DDB_G0272813", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "P34112", "DDB_G0272813", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259" ] }, "reaction_10585390": { "compartment": "compartment_7660", "id": "reaction_10585390", "reactome": "R-DDI-174139", "name": "Dissociation of phospho-Cdh1 from the APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585236" ], "products": [ "species_10585192", "species_10585234" ], "modifiers": [], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "DDB_G0287259", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230" ] }, "reaction_10585458": { "compartment": "compartment_70101", "id": "reaction_10585458", "reactome": "R-DDI-174238", "name": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583652" ], "products": [ "species_10585386", "species_10585456" ], "modifiers": [], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54MZ3", "DDB_G0285601", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134" ] }, "reaction_10585452": { "compartment": "compartment_70101", "id": "reaction_10585452", "reactome": "R-DDI-174227", "name": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10585411" ], "products": [ "species_10585413" ], "modifiers": [ [ "species_10585386", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54MZ3", "DDB_G0285601", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54MZ3", "DDB_G0285601", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54MZ3", "DDB_G0285601" ] }, "reaction_10585369": { "compartment": "compartment_70101", "id": "reaction_10585369", "reactome": "R-DDI-174104", "name": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10585364" ], "products": [ "species_10585366" ], "modifiers": [ [ "species_10583652", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601" ] }, "reaction_10585888": { "compartment": "compartment_70101", "id": "reaction_10585888", "reactome": "R-DDI-179417", "name": "Multiubiquitination of Nek2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10585881" ], "products": [ "species_10585885" ], "modifiers": [ [ "species_10585881", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601", "Q55BN8", "DDB_G0270814", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601", "Q55BN8", "DDB_G0270814", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601", "Q55BN8", "DDB_G0270814" ] }, "reaction_10585890": { "compartment": "compartment_70101", "id": "reaction_10585890", "reactome": "R-DDI-179421", "name": "Degradation of multiubiquitinated Nek2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585885" ], "products": [ "species_10577037", "species_10583652" ], "modifiers": [], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601", "Q55BN8", "DDB_G0270814", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601" ] }, "reaction_10585883": { "compartment": "compartment_70101", "id": "reaction_10585883", "reactome": "R-DDI-179410", "name": "Association of Nek2A with MCC:APC/C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585879", "species_10583652" ], "products": [ "species_10585881" ], "modifiers": [], "additional_components": [ "DDB_G0270814", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601", "Q55BN8", "DDB_G0270814" ] }, "reaction_10585444": { "compartment": "compartment_70101", "id": "reaction_10585444", "reactome": "R-DDI-174202", "name": "Degradation of multiubiquitinated Securin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585398" ], "products": [ "species_10577037", "species_10585386" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54MZ3", "DDB_G0285601", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54MZ3", "DDB_G0285601", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10585401": { "compartment": "compartment_70101", "id": "reaction_10585401", "reactome": "R-DDI-174144", "name": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10585394" ], "products": [ "species_10585398" ], "modifiers": [ [ "species_10585386", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54MZ3", "DDB_G0285601", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54MZ3", "DDB_G0285601", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54MZ3", "DDB_G0285601" ] }, "reaction_10585384": { "compartment": "compartment_7660", "id": "reaction_10585384", "reactome": "R-DDI-174119", "name": "Free APC/C phosphorylated by Plk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585234" ], "products": [ "species_10585234" ], "modifiers": [ [ "species_10583697", "catalyst" ] ], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "DDB_G0274503" ] }, "reaction_10585330": { "compartment": "compartment_7660", "id": "reaction_10585330", "reactome": "R-DDI-174058", "name": "Degradation of multiubiquitinated Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585238" ], "products": [ "species_10585234", "species_10576865" ], "modifiers": [ [ "species_10585327", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q27563", "DDB_G0267408", "P02889", "DDB_G0272564", "P34119", "DDB_G0280969", "Q552Y8", "DDB_G0275753", "Q55G04", "DDB_G0268538", "Q967U1", "DDB_G0285099", "Q54XM7", "DDB_G0278847", "P34120", "DDB_G0272831", "Q86A21", "DDB_G0272969", "Q54S82", "DDB_G0282617", "Q54QR2", "DDB_G0283679", "Q55DY7", "DDB_G0269472", "Q55D66", "DDB_G0269772", "Q556Q0", "DDB_G0273163", "Q54BC8", "DDB_G0293784", "Q55GJ6", "DDB_G0267390", "Q55BV5", "DDB_G0270784", "Q86JA1", "DDB_G0276917", "Q54PN7", "DDB_G0284415", "P34123", "DDB_G0289003", "P34124", "DDB_G0292382", "Q54PJ1", "DDB_G0284517", "Q54JM5", "DDB_G0287953", "Q54HW1", "DDB_G0289189", "Q54UB5", "DDB_G0281315", "Q54UJ0", "DDB_G0281051", "Q54NQ0", "DDB_G0285105", "Q54BC6", "DDB_G0293752", "Q1ZXD3", "DDB_G0288621", "Q553E0", "DDB_G0275775", "Q86IJ1", "DDB_G0272566", "Q559F4", "DDB_G0272951", "Q27562", "DDB_G0282363", "Q55C75", "DDB_G0270188", "Q54DM7", "DDB_G0292122", "Q54WI8", "DDB_G0279633" ] }, "reaction_10585241": { "compartment": "compartment_7660", "id": "reaction_10585241", "reactome": "R-DDI-174057", "name": "Multiubiquitination of APC/C-associated Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585236", "species_10576865" ], "products": [ "species_10585238" ], "modifiers": [ [ "species_10585236", "catalyst" ] ], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259" ] }, "reaction_10598791": { "compartment": "compartment_172574", "id": "reaction_10598791", "reactome": "R-DDI-1675795", "name": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806198", "species_29356" ], "products": [ "species_29372", "species_1806195" ], "modifiers": [ [ "species_10598788", "catalyst" ] ], "additional_components": [ "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250" ] }, "reaction_10599016": { "compartment": "compartment_172574", "id": "reaction_10599016", "reactome": "R-DDI-1676065", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806289" ], "products": [ "species_1806212", "species_29372" ], "modifiers": [ [ "species_10598788", "catalyst" ] ], "additional_components": [ "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250" ] }, "reaction_10599004": { "compartment": "compartment_172574", "id": "reaction_10599004", "reactome": "R-DDI-1676024", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806195" ], "products": [ "species_1806198", "species_29370" ], "modifiers": [ [ "species_10598879", "catalyst" ] ], "additional_components": [ "Q54S78", "DDB_G0282625", "Q55FX5", "DDB_G0282625", "P54673", "DDB_G0278727", "P54674", "DDB_G0283081", "P54675", "DDB_G0275011", "species_74112", "species_29926", "P54676", "DDB_G0289601", "species_266099", "Q54S77", "DDB_G0282627" ] }, "reaction_10599088": { "compartment": "compartment_20699", "id": "reaction_10599088", "reactome": "R-DDI-1676185", "name": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524146" ], "products": [ "species_29370", "species_1806217" ], "modifiers": [ [ "species_10598801", "catalyst" ] ], "additional_components": [ "DDB_G0277537" ] }, "reaction_10599059": { "compartment": "compartment_20699", "id": "reaction_10599059", "reactome": "R-DDI-1676133", "name": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806217" ], "products": [ "species_29372", "species_1524146" ], "modifiers": [ [ "species_10599048", "catalyst" ] ], "additional_components": [ "DDB_G0271630" ] }, "reaction_10598871": { "compartment": "compartment_20699", "id": "reaction_10598871", "reactome": "R-DDI-1675928", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806217" ], "products": [ "species_1806230", "species_29370" ], "modifiers": [ [ "species_10598868", "catalyst" ] ], "additional_components": [ "Q55FX5", "DDB_G0282625", "P54673", "DDB_G0278727", "P54674", "DDB_G0283081", "P54675", "DDB_G0275011", "Q54S78", "DDB_G0282625", "species_74112", "species_29926" ] }, "reaction_10599081": { "compartment": "compartment_20699", "id": "reaction_10599081", "reactome": "R-DDI-1676152", "name": "PI4KB binds to ARF1/3:GTP at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599079", "species_10598835" ], "products": [ "species_10598837" ], "modifiers": [], "additional_components": [ "P54677", "DDB_G0288485", "Q54LR9", "DDB_G0286479", "species_29438", "O00909", "DDB_G0289173", "Q54Y34", "DDB_G0292332", "Q1ZXA5", "DDB_G0292332", "Q54YV7", "DDB_G0278057", "Q54HK2", "DDB_G0289435", "Q55AR1", "DDB_G0271792", "Q54JJ3", "DDB_G0288015", "Q54SH9", "DDB_G0282457", "Q54V41", "DDB_G0280633", "Q54V47", "DDB_G0280621", "Q54VB0", "DDB_G0280479", "P54677", "DDB_G0288485", "Q54LR9", "DDB_G0286479", "species_29438", "O00909", "DDB_G0289173", "Q54Y34", "DDB_G0292332", "Q1ZXA5", "DDB_G0292332", "Q54YV7", "DDB_G0278057", "Q54HK2", "DDB_G0289435", "Q55AR1", "DDB_G0271792", "Q54JJ3", "DDB_G0288015", "Q54SH9", "DDB_G0282457", "Q54V41", "DDB_G0280633", "Q54V47", "DDB_G0280621", "Q54VB0", "DDB_G0280479" ] }, "reaction_10598809": { "compartment": "compartment_20699", "id": "reaction_10598809", "reactome": "R-DDI-1675824", "name": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806165", "species_29356" ], "products": [ "species_29372", "species_1806217" ], "modifiers": [ [ "species_10598806", "catalyst" ] ], "additional_components": [ "DDB_G0267462" ] }, "reaction_10598840": { "compartment": "compartment_20699", "id": "reaction_10598840", "reactome": "R-DDI-1675883", "name": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524146" ], "products": [ "species_29370", "species_1806217" ], "modifiers": [ [ "species_10598837", "catalyst" ] ], "additional_components": [ "P54677", "DDB_G0288485", "Q54LR9", "DDB_G0286479", "species_29438", "O00909", "DDB_G0289173", "Q54Y34", "DDB_G0292332", "Q1ZXA5", "DDB_G0292332", "Q54YV7", "DDB_G0278057", "Q54HK2", "DDB_G0289435", "Q55AR1", "DDB_G0271792", "Q54JJ3", "DDB_G0288015", "Q54SH9", "DDB_G0282457", "Q54V41", "DDB_G0280633", "Q54V47", "DDB_G0280621", "Q54VB0", "DDB_G0280479" ] }, "reaction_10599051": { "compartment": "compartment_20699", "id": "reaction_10599051", "reactome": "R-DDI-1676114", "name": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806159" ], "products": [ "species_29372", "species_1524146" ], "modifiers": [ [ "species_10599048", "catalyst" ] ], "additional_components": [ "DDB_G0271630" ] }, "reaction_10599115": { "compartment": "compartment_20699", "id": "reaction_10599115", "reactome": "R-DDI-1676204", "name": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806230", "species_29356" ], "products": [ "species_29372", "species_1806217" ], "modifiers": [ [ "species_10599112", "catalyst" ] ], "additional_components": [ "Q54MG8", "DDB_G0285967" ] }, "reaction_10598911": { "compartment": "compartment_20699", "id": "reaction_10598911", "reactome": "R-DDI-1675961", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524146" ], "products": [ "species_29370", "species_1806159" ], "modifiers": [ [ "species_10598879", "catalyst" ] ], "additional_components": [ "Q54S78", "DDB_G0282625", "Q55FX5", "DDB_G0282625", "P54673", "DDB_G0278727", "P54674", "DDB_G0283081", "P54675", "DDB_G0275011", "species_74112", "species_29926", "P54676", "DDB_G0289601", "species_266099", "Q54S77", "DDB_G0282627" ] }, "reaction_10599056": { "compartment": "compartment_12045", "id": "reaction_10599056", "reactome": "R-DDI-1676124", "name": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806234" ], "products": [ "species_29372", "species_426639" ], "modifiers": [ [ "species_10599053", "catalyst" ] ], "additional_components": [ "DDB_G0271630" ] }, "reaction_10598804": { "compartment": "compartment_12045", "id": "reaction_10598804", "reactome": "R-DDI-1675813", "name": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426639" ], "products": [ "species_29370", "species_1806234" ], "modifiers": [ [ "species_10598801", "catalyst" ] ], "additional_components": [ "DDB_G0277537" ] }, "reaction_10617403": { "compartment": "compartment_70101", "id": "reaction_10617403", "reactome": "R-DDI-6809777", "name": "PI3P is dephosphorylated to PI by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5676030" ], "products": [ "species_29372", "species_426639" ], "modifiers": [ [ "species_10617398", "catalyst" ] ], "additional_components": [ "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54TD5", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258" ] }, "reaction_10617400": { "compartment": "compartment_70101", "id": "reaction_10617400", "reactome": "R-DDI-6809764", "name": "SBF1 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598734", "species_10617396" ], "products": [ "species_10617398" ], "modifiers": [], "additional_components": [ "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54TD5", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54TD5", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258" ] }, "reaction_10617406": { "compartment": "compartment_70101", "id": "reaction_10617406", "reactome": "R-DDI-6809778", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6809774" ], "products": [ "species_29372", "species_422529" ], "modifiers": [ [ "species_10617398", "catalyst" ] ], "additional_components": [ "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54TD5", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258" ] }, "reaction_10599073": { "compartment": "compartment_876", "id": "reaction_10599073", "reactome": "R-DDI-1676149", "name": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_202247" ], "products": [ "species_29372", "species_392417" ], "modifiers": [ [ "species_10587224", "catalyst" ] ], "additional_components": [ "DDB_G0286557" ] }, "reaction_10598595": { "compartment": "compartment_876", "id": "reaction_10598595", "reactome": "R-DDI-1675773", "name": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_202247" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10598592", "catalyst" ] ], "additional_components": [ "Q54M96", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635", "Q54VR4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q86D86", "DDB_G0283615", "Q54DL4", "DDB_G0292190" ] }, "reaction_10599043": { "compartment": "compartment_876", "id": "reaction_10599043", "reactome": "R-DDI-1676109", "name": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10599040", "catalyst" ] ], "additional_components": [ "Q54DK0", "DDB_G0292252", "P54675", "DDB_G0275011", "P54673", "DDB_G0278727", "Q54S78", "DDB_G0282625", "Q55FX5", "DDB_G0282625", "P54674", "DDB_G0283081", "species_74112", "species_29926", "species_266099" ] }, "reaction_10617313": { "compartment": "compartment_70101", "id": "reaction_10617313", "reactome": "R-DDI-6809254", "name": "MTMR8 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617309", "species_10617283" ], "products": [ "species_10617311" ], "modifiers": [], "additional_components": [ "Q55AZ2", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54TD5", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54TD5", "DDB_G0293258", "Q54PT8", "DDB_G0293258" ] }, "reaction_10598914": { "compartment": "compartment_876", "id": "reaction_10598914", "reactome": "R-DDI-1675988", "name": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_392417" ], "products": [ "species_29372", "species_426658" ], "modifiers": [ [ "species_10598818", "catalyst" ] ], "additional_components": [ "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392" ] }, "reaction_10599013": { "compartment": "compartment_876", "id": "reaction_10599013", "reactome": "R-DDI-1676048", "name": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10599010", "catalyst" ] ], "additional_components": [ "Q54DK0", "DDB_G0292252", "P54675", "DDB_G0275011", "P54673", "DDB_G0278727", "Q54S78", "DDB_G0282625", "Q55FX5", "DDB_G0282625", "P54674", "DDB_G0283081" ] }, "reaction_10598821": { "compartment": "compartment_876", "id": "reaction_10598821", "reactome": "R-DDI-1675836", "name": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806224" ], "products": [ "species_1806276", "species_29372" ], "modifiers": [ [ "species_10598818", "catalyst" ] ], "additional_components": [ "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392" ] }, "reaction_10598796": { "compartment": "compartment_876", "id": "reaction_10598796", "reactome": "R-DDI-1675810", "name": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426658" ], "products": [ "species_1806240", "species_29370" ], "modifiers": [ [ "species_10598793", "catalyst" ] ], "additional_components": [ "Q54M96", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635", "Q54VR4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q86D86", "DDB_G0283615", "Q54DL4", "DDB_G0292190" ] }, "reaction_10599086": { "compartment": "compartment_876", "id": "reaction_10599086", "reactome": "R-DDI-1676177", "name": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_29372", "species_392417" ], "modifiers": [ [ "species_10599083", "catalyst" ] ], "additional_components": [ "Q54PV1", "DDB_G0284187", "Q54W40", "DDB_G0279927", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392" ] }, "reaction_10617325": { "compartment": "compartment_70101", "id": "reaction_10617325", "reactome": "R-DDI-6809309", "name": "MTMR6 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617309", "species_10598992" ], "products": [ "species_10617323" ], "modifiers": [], "additional_components": [ "Q55AZ2", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54TD5", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258" ] }, "reaction_10617330": { "compartment": "compartment_876", "id": "reaction_10617330", "reactome": "R-DDI-6809320", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806224" ], "products": [ "species_29372", "species_1806240" ], "modifiers": [ [ "species_10617327", "catalyst" ] ], "additional_components": [ "Q54PT8", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258" ] }, "reaction_10599091": { "compartment": "compartment_876", "id": "reaction_10599091", "reactome": "R-DDI-1676203", "name": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806224" ], "products": [ "species_29372", "species_1806240" ], "modifiers": [ [ "species_10598999", "catalyst" ] ], "additional_components": [ "Q54PT8", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54H00", "DDB_G0289807", "Q54D97", "DDB_G0292392" ] }, "reaction_10617333": { "compartment": "compartment_876", "id": "reaction_10617333", "reactome": "R-DDI-6809325", "name": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_29356" ], "products": [ "species_29372", "species_426658" ], "modifiers": [ [ "species_10617327", "catalyst" ] ], "additional_components": [ "Q54PT8", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258" ] }, "reaction_10599062": { "compartment": "compartment_876", "id": "reaction_10599062", "reactome": "R-DDI-1676134", "name": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_113592" ], "products": [ "species_1806224", "species_29370" ], "modifiers": [ [ "species_10598793", "catalyst" ] ], "additional_components": [ "Q54M96", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635", "Q54VR4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q86D86", "DDB_G0283615", "Q54DL4", "DDB_G0292190" ] }, "reaction_10587227": { "compartment": "compartment_70101", "id": "reaction_10587227", "reactome": "R-DDI-199456", "name": "PTEN dephosphorylates PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179838" ], "products": [ "species_29372", "species_179856" ], "modifiers": [ [ "species_10587224", "catalyst" ] ], "additional_components": [ "DDB_G0286557" ] }, "reaction_10599002": { "compartment": "compartment_876", "id": "reaction_10599002", "reactome": "R-DDI-1675994", "name": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_29356" ], "products": [ "species_29372", "species_426658" ], "modifiers": [ [ "species_10598999", "catalyst" ] ], "additional_components": [ "Q54PT8", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54H00", "DDB_G0289807", "Q54D97", "DDB_G0292392" ] }, "reaction_10598909": { "compartment": "compartment_876", "id": "reaction_10598909", "reactome": "R-DDI-1675949", "name": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179838" ], "products": [ "species_29372", "species_202247" ], "modifiers": [ [ "species_10598906", "catalyst" ] ], "additional_components": [ "Q54PV1", "DDB_G0284187", "Q54W40", "DDB_G0279927", "Q8I7P3", "DDB_G0267462" ] }, "reaction_10599070": { "compartment": "compartment_876", "id": "reaction_10599070", "reactome": "R-DDI-1676145", "name": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_113592" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10599067", "catalyst" ] ], "additional_components": [ "Q86D86", "DDB_G0283615", "Q54DL4", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635" ] }, "reaction_10618317": { "compartment": "compartment_876", "id": "reaction_10618317", "reactome": "R-DDI-6814797", "name": "ENPP6 hydrolyzes lysophosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_2239407" ], "products": [ "species_6814794", "species_6814795" ], "modifiers": [ [ "species_10618314", "catalyst" ] ], "additional_components": [ "DDB_G0285897" ] }, "reaction_10598240": { "compartment": "compartment_20699", "id": "reaction_10598240", "reactome": "R-DDI-1483211", "name": "PC:PITPNB is transported from the Golgi membrane to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598146" ], "products": [ "species_10598238" ], "modifiers": [], "additional_components": [ "Q9NCL8", "DDB_G0290069", "species_426925", "species_426925", "Q9NCL8", "DDB_G0290069" ] }, "reaction_10598259": { "compartment": "compartment_12045", "id": "reaction_10598259", "reactome": "R-DDI-1483229", "name": "PI:PITPNB is transported from the ER membrane to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598242" ], "products": [ "species_10598144" ], "modifiers": [], "additional_components": [ "species_426639", "Q9NCL8", "DDB_G0290069", "species_426639", "Q9NCL8", "DDB_G0290069" ] }, "reaction_10598148": { "compartment": "compartment_20699", "id": "reaction_10598148", "reactome": "R-DDI-1483087", "name": "PI is exchanged with PC by PITPNB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429785", "species_10598144" ], "products": [ "species_1524146", "species_10598146" ], "modifiers": [], "additional_components": [ "species_426639", "Q9NCL8", "DDB_G0290069", "Q9NCL8", "DDB_G0290069", "species_426925" ] }, "reaction_10599024": { "compartment": "compartment_171062", "id": "reaction_10599024", "reactome": "R-DDI-1676105", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806205" ], "products": [ "species_29372", "species_1806259" ], "modifiers": [ [ "species_10599021", "catalyst" ] ], "additional_components": [ "Q54C52", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PT8", "DDB_G0293258", "Q55AZ2", "DDB_G0293258" ] }, "reaction_10617363": { "compartment": "compartment_70101", "id": "reaction_10617363", "reactome": "R-DDI-6809680", "name": "MTMR12 binds MTM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617359", "species_10598708" ], "products": [ "species_10617361" ], "modifiers": [], "additional_components": [ "Q54YC2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PT8", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PT8", "DDB_G0293258", "Q55AZ2", "DDB_G0293258" ] }, "reaction_10598882": { "compartment": "compartment_171062", "id": "reaction_10598882", "reactome": "R-DDI-1675939", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806199", "species_113592" ], "products": [ "species_29370", "species_1806200" ], "modifiers": [ [ "species_10598879", "catalyst" ] ], "additional_components": [ "Q54S78", "DDB_G0282625", "Q55FX5", "DDB_G0282625", "P54673", "DDB_G0278727", "P54674", "DDB_G0283081", "P54675", "DDB_G0275011", "species_74112", "species_29926", "P54676", "DDB_G0289601", "species_266099", "Q54S77", "DDB_G0282627" ] }, "reaction_10617367": { "compartment": "compartment_70101", "id": "reaction_10617367", "reactome": "R-DDI-6809707", "name": "MTMR12 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598734", "species_10617359" ], "products": [ "species_10617365" ], "modifiers": [], "additional_components": [ "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258" ] }, "reaction_10618629": { "compartment": "compartment_70101", "id": "reaction_10618629", "reactome": "R-DDI-8849969", "name": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8849959" ], "products": [ "species_29372", "species_8849958" ], "modifiers": [ [ "species_10618626", "catalyst" ] ], "additional_components": [ "species_179838", "species_1806238", "species_179856", "species_1806200", "species_1806205", "species_6810408", "Q86HL0", "DDB_G0290653", "Q55AW9", "DDB_G0271630", "Q54FY6", "DDB_G0290653" ] }, "reaction_10599065": { "compartment": "compartment_171062", "id": "reaction_10599065", "reactome": "R-DDI-1676141", "name": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806200" ], "products": [ "species_29372", "species_1806199" ], "modifiers": [ [ "species_10599021", "catalyst" ] ], "additional_components": [ "Q54C52", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PT8", "DDB_G0293258", "Q55AZ2", "DDB_G0293258" ] }, "reaction_10617370": { "compartment": "compartment_171062", "id": "reaction_10617370", "reactome": "R-DDI-6809720", "name": "PI3P is dephosphorylated to PI by MTM1:MTMR12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806200" ], "products": [ "species_29372", "species_1806199" ], "modifiers": [ [ "species_10617361", "catalyst" ] ], "additional_components": [ "Q54C52", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PT8", "DDB_G0293258", "Q55AZ2", "DDB_G0293258" ] }, "reaction_10599118": { "compartment": "compartment_171062", "id": "reaction_10599118", "reactome": "R-DDI-1676206", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806180", "species_113592" ], "products": [ "species_29370", "species_1806238" ], "modifiers": [ [ "species_10598854", "catalyst" ] ], "additional_components": [ "Q54S78", "DDB_G0282625", "Q55FX5", "DDB_G0282625", "P54673", "DDB_G0278727", "P54674", "DDB_G0283081", "P54675", "DDB_G0275011", "species_74112", "species_29926" ] }, "reaction_10598208": { "compartment": "compartment_12045", "id": "reaction_10598208", "reactome": "R-DDI-1483182", "name": "PC is hydrolyzed to PA and choline by PLD1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_264618", "species_426755" ], "modifiers": [ [ "species_10598205", "catalyst" ] ], "additional_components": [ "Q54WR4", "DDB_G0279483", "Q54Z25", "DDB_G0277949", "Q54Q49", "DDB_G0284155", "Q54UK0", "DDB_G0281031" ] }, "reaction_10612690": { "compartment": "compartment_70101", "id": "reaction_10612690", "reactome": "R-DDI-6786650", "name": "DDHD1,2 hydrolyse PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1602448" ], "products": [ "species_1602447", "species_1602366" ], "modifiers": [ [ "species_10612687", "catalyst" ] ], "additional_components": [ "Q86KP6", "DDB_G0276935", "Q54EA5", "DDB_G0291694", "Q55DN9", "DDB_G0276935", "Q55DP0", "DDB_G0276935" ] }, "reaction_10594009": { "compartment": "compartment_12045", "id": "reaction_10594009", "reactome": "R-DDI-549112", "name": "G3P is acylated to 1-acyl LPA by AGPAT6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_76114" ], "products": [ "species_1500604", "species_76194" ], "modifiers": [ [ "species_10581703", "catalyst" ] ], "additional_components": [ "DDB_G0274969" ] }, "reaction_10623946": { "compartment": "compartment_17906", "id": "reaction_10623946", "reactome": "R-DDI-8954398", "name": "PLD6 dimer hydrolyses cardiolipin to PA and PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189422", "species_8954419" ], "products": [ "species_8954401", "species_1500590" ], "modifiers": [ [ "species_10623943", "catalyst" ] ], "additional_components": [ "Q54TK6", "DDB_G0281695" ] }, "reaction_10585976": { "compartment": "compartment_5460", "id": "reaction_10585976", "reactome": "R-DDI-188467", "name": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_188458" ], "products": [ "species_31649", "species_188451" ], "modifiers": [ [ "species_10585973", "catalyst" ] ], "additional_components": [ "DDB_G0283951" ] }, "reaction_10597949": { "compartment": "compartment_17906", "id": "reaction_10597949", "reactome": "R-DDI-1482548", "name": "1-acyl LPA is acylated to PA by AGPAT5 (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500580" ], "products": [ "species_1500590", "species_76194" ], "modifiers": [ [ "species_10597946", "catalyst" ] ], "additional_components": [ "DDB_G0288523" ] }, "reaction_10622766": { "compartment": "compartment_5460", "id": "reaction_10622766", "reactome": "R-DDI-8878654", "name": "ACP6 hydrolyses MYS-LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8878649", "species_113521" ], "products": [ "species_113548", "species_8934414" ], "modifiers": [ [ "species_10622763", "catalyst" ] ], "additional_components": [ "DDB_G0284363" ] }, "reaction_10581726": { "compartment": "compartment_12045", "id": "reaction_10581726", "reactome": "R-DDI-75885", "name": "1-acyl LPA is acylated to PA by AGPAT (LPAAT)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500604", "species_1500578" ], "products": [ "species_426755", "species_76194" ], "modifiers": [ [ "species_10581723", "catalyst" ] ], "additional_components": [ "Q54IT8", "DDB_G0288523", "Q55CZ2", "DDB_G0288523", "Q54EU4", "DDB_G0291332", "Q554U0", "DDB_G0274969", "Q54X10", "DDB_G0279277", "Q54IG1", "DDB_G0288863" ] }, "reaction_10611940": { "compartment": "compartment_12045", "id": "reaction_10611940", "reactome": "R-DDI-5696448", "name": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696449", "species_6782195" ], "products": [ "species_76194", "species_1500596" ], "modifiers": [ [ "species_10611937", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10598028": { "compartment": "compartment_12045", "id": "reaction_10598028", "reactome": "R-DDI-1482889", "name": "DAG is acylated to TAG by DGAT1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_1500594", "species_76194" ], "modifiers": [ [ "species_10598025", "catalyst" ] ], "additional_components": [ "Q55BH9", "DDB_G0271342", "Q54GC1", "DDB_G0290279" ] }, "reaction_10618492": { "compartment": "compartment_12045", "id": "reaction_10618492", "reactome": "R-DDI-8848580", "name": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_1500594", "species_76194" ], "modifiers": [ [ "species_10618487", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10598017": { "compartment": "compartment_12045", "id": "reaction_10598017", "reactome": "R-DDI-1482861", "name": "MLCL is acylated to CL by LCLAT1 (ER)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1524069" ], "products": [ "species_1524081", "species_76194" ], "modifiers": [ [ "species_10581717", "catalyst" ] ], "additional_components": [ "Q55CZ2", "DDB_G0288523", "Q54IT8", "DDB_G0288523" ] }, "reaction_10598019": { "compartment": "compartment_12045", "id": "reaction_10598019", "reactome": "R-DDI-1482867", "name": "DLCL is acylated to MLCL by LCLAT1 (ER)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524080", "species_1500578" ], "products": [ "species_76194", "species_1524069" ], "modifiers": [ [ "species_10581717", "catalyst" ] ], "additional_components": [ "Q55CZ2", "DDB_G0288523", "Q54IT8", "DDB_G0288523" ] }, "reaction_10597996": { "compartment": "compartment_70616", "id": "reaction_10597996", "reactome": "R-DDI-1482781", "name": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524075", "species_1498773" ], "products": [ "species_1524072", "species_1524079" ], "modifiers": [ [ "species_10597993", "catalyst" ] ], "additional_components": [ "DDB_G0291922" ] }, "reaction_10598012": { "compartment": "compartment_70616", "id": "reaction_10598012", "reactome": "R-DDI-1482850", "name": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524083", "species_1498773" ], "products": [ "species_1524072", "species_1524089" ], "modifiers": [ [ "species_10597993", "catalyst" ] ], "additional_components": [ "DDB_G0291922" ] }, "reaction_10605155": { "compartment": "compartment_876", "id": "reaction_10605155", "reactome": "R-DDI-5333678", "name": "CPNEs bind PL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605151", "species_171142" ], "products": [ "species_10605153" ], "modifiers": [ [ "species_74016", "catalyst" ] ], "additional_components": [ "Q54P51", "DDB_G0284791", "Q55GG1", "DDB_G0267688", "Q1ZXB3", "DDB_G0291498", "Q54FY7", "DDB_G0290529", "Q7YXU4", "DDB_G0293008", "Q86K21", "DDB_G0272875", "species_171142", "Q54P51", "DDB_G0284791", "Q55GG1", "DDB_G0267688", "Q1ZXB3", "DDB_G0291498", "Q54FY7", "DDB_G0290529", "Q7YXU4", "DDB_G0293008", "Q86K21", "DDB_G0272875" ] }, "reaction_10598166": { "compartment": "compartment_12045", "id": "reaction_10598166", "reactome": "R-DDI-1483121", "name": "PA is converted to CDP-DAG by CDS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_426755" ], "products": [ "species_111294", "species_426955" ], "modifiers": [ [ "species_10598163", "catalyst" ] ], "additional_components": [ "Q55D90", "DDB_G0269742", "species_29926" ] }, "reaction_10598092": { "compartment": "compartment_12045", "id": "reaction_10598092", "reactome": "R-DDI-1482976", "name": "CDP-DAG is converted to PI by CDIPT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426955", "species_426910" ], "products": [ "species_426639", "species_109395" ], "modifiers": [ [ "species_10598089", "catalyst" ] ], "additional_components": [ "Q54P27", "DDB_G0284857", "species_29926", "species_266099" ] }, "reaction_10620477": { "compartment": "compartment_70101", "id": "reaction_10620477", "reactome": "R-DDI-8869241", "name": "PITPNM1,2,3 exchange PI for PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426639", "species_1602448" ], "products": [ "species_426755", "species_426658" ], "modifiers": [ [ "species_10620474", "catalyst" ] ], "additional_components": [ "Q55DN9", "DDB_G0276935", "Q54EA5", "DDB_G0291694", "Q86KP6", "DDB_G0276935", "Q55DP0", "DDB_G0276935", "Q9NCL7", "DDB_G0274579", "Q54D93", "DDB_G0292426", "Q54VC7", "DDB_G0280449" ] }, "reaction_10598213": { "compartment": "compartment_12045", "id": "reaction_10598213", "reactome": "R-DDI-1483186", "name": "PC is converted to PS by PTDSS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_200736" ], "products": [ "species_264618", "species_1500646" ], "modifiers": [ [ "species_10598210", "catalyst" ] ], "additional_components": [ "DDB_G0278159" ] }, "reaction_10598156": { "compartment": "compartment_12045", "id": "reaction_10598156", "reactome": "R-DDI-1483089", "name": "PE is converted to PS by PTDSS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736", "species_1500581" ], "products": [ "species_1498751", "species_1500646" ], "modifiers": [ [ "species_10598153", "catalyst" ] ], "additional_components": [ "DDB_G0278159" ] }, "reaction_10598171": { "compartment": "compartment_70616", "id": "reaction_10598171", "reactome": "R-DDI-1483165", "name": "PA is converted to CDP-DAG by CDS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524101", "species_110577" ], "products": [ "species_159450", "species_1524064" ], "modifiers": [ [ "species_10598168", "catalyst" ] ], "additional_components": [ "DDB_G0269742" ] }, "reaction_10619810": { "compartment": "compartment_984", "id": "reaction_10619810", "reactome": "R-DDI-8865637", "name": "MFSD2A transports LPC from extracellular region to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8865642", "species_74113" ], "products": [ "species_8865629", "species_83910" ], "modifiers": [ [ "species_10619807", "catalyst" ] ], "additional_components": [ "DDB_G0282159" ] }, "reaction_10598179": { "compartment": "compartment_12045", "id": "reaction_10598179", "reactome": "R-DDI-1483174", "name": "PE is methylated to PC by PEMT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_1500581" ], "products": [ "species_426925", "species_71285" ], "modifiers": [ [ "species_10598176", "catalyst" ] ], "additional_components": [ "DDB_G0282527" ] }, "reaction_10598082": { "compartment": "compartment_20699", "id": "reaction_10598082", "reactome": "R-DDI-1482973", "name": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524057", "species_1524060" ], "products": [ "species_429785", "species_109395" ], "modifiers": [ [ "species_10598079", "catalyst" ] ], "additional_components": [ "species_29926", "species_266099", "Q54XM0", "DDB_G0278947" ] }, "reaction_10611829": { "compartment": "compartment_876", "id": "reaction_10611829", "reactome": "R-DDI-5694485", "name": "ABHD3 hydrolyses LPC(14:0) to 1AGPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5694502" ], "products": [ "species_5694457", "species_1861754" ], "modifiers": [ [ "species_10611826", "catalyst" ] ], "additional_components": [ "Q55C73", "DDB_G0270192", "Q54H38", "DDB_G0289723" ] }, "reaction_10589593": { "compartment": "compartment_984", "id": "reaction_10589593", "reactome": "R-DDI-372519", "name": "AcCho is hydrolyzed to Cho and acetate by ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_372533" ], "products": [ "species_1524044", "species_264638" ], "modifiers": [ [ "species_10589588", "catalyst" ], [ "species_10589591", "inhibitor" ] ], "additional_components": [ "Q54ET7", "DDB_G0291344", "Q86L18", "DDB_G0291344", "P18142", "DDB_G0283085", "Q54N21", "DDB_G0291344", "Q54WD8", "DDB_G0291344", "P21837", "DDB_G0285419", "Q54ET7", "DDB_G0291344", "Q86L18", "DDB_G0291344", "P18142", "DDB_G0283085", "Q54N21", "DDB_G0291344", "Q54WD8", "DDB_G0291344", "P21837", "DDB_G0285419" ] }, "reaction_10598121": { "compartment": "compartment_70101", "id": "reaction_10598121", "reactome": "R-DDI-1483004", "name": "Cho is phosphorylated to PCho by CHK dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264618", "species_113592" ], "products": [ "species_29370", "species_1524071" ], "modifiers": [ [ "species_10598118", "catalyst" ] ], "additional_components": [ "Q554D8", "DDB_G0275265", "Q869T9", "DDB_G0274955" ] }, "reaction_10598137": { "compartment": "compartment_12045", "id": "reaction_10598137", "reactome": "R-DDI-1483081", "name": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_1524071" ], "products": [ "species_111294", "species_1524060" ], "modifiers": [ [ "species_10598134", "catalyst" ] ], "additional_components": [ "Q54GD2", "DDB_G0290229" ] }, "reaction_10598058": { "compartment": "compartment_12045", "id": "reaction_10598058", "reactome": "R-DDI-1482961", "name": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524060", "species_1500596" ], "products": [ "species_426925", "species_109395" ], "modifiers": [ [ "species_10598055", "catalyst" ] ], "additional_components": [ "Q8T2Q6", "DDB_G0275235", "Q54XM0", "DDB_G0278947", "Q550W1", "DDB_G0276763", "Q55AQ3", "DDB_G0271794", "species_29926", "species_266099" ] }, "reaction_10592589": { "compartment": "compartment_984", "id": "reaction_10592589", "reactome": "R-DDI-444433", "name": "Cho transports from the extracellular space to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264638" ], "products": [ "species_264618" ], "modifiers": [ [ "species_10592586", "catalyst" ] ], "additional_components": [ "Q54I48", "DDB_G0289013", "Q54IJ2", "DDB_G0288717" ] }, "reaction_10597968": { "compartment": "compartment_12045", "id": "reaction_10597968", "reactome": "R-DDI-1482635", "name": "2-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498730", "species_1500578" ], "products": [ "species_1483256", "species_76194" ], "modifiers": [ [ "species_10597938", "catalyst" ] ], "additional_components": [ "Q54IT8", "DDB_G0288523", "Q55CZ2", "DDB_G0288523", "Q54X10", "DDB_G0279277" ] }, "reaction_10597941": { "compartment": "compartment_12045", "id": "reaction_10597941", "reactome": "R-DDI-1482539", "name": "1-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498740" ], "products": [ "species_1483256", "species_76194" ], "modifiers": [ [ "species_10597938", "catalyst" ] ], "additional_components": [ "Q54IT8", "DDB_G0288523", "Q55CZ2", "DDB_G0288523", "Q54X10", "DDB_G0279277" ] }, "reaction_10597985": { "compartment": "compartment_12045", "id": "reaction_10597985", "reactome": "R-DDI-1482685", "name": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1524028" ], "products": [ "species_1498750", "species_1524021" ], "modifiers": [ [ "species_10597959", "catalyst" ] ], "additional_components": [ "DDB_G0284449" ] }, "reaction_10597962": { "compartment": "compartment_12045", "id": "reaction_10597962", "reactome": "R-DDI-1482612", "name": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_975614" ], "products": [ "species_1498750", "species_1524021" ], "modifiers": [ [ "species_10597959", "catalyst" ] ], "additional_components": [ "DDB_G0284449" ] }, "reaction_10597954": { "compartment": "compartment_12045", "id": "reaction_10597954", "reactome": "R-DDI-1482598", "name": "1-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498733", "species_1500578" ], "products": [ "species_426639", "species_76194" ], "modifiers": [ [ "species_10597951", "catalyst" ] ], "additional_components": [ "DDB_G0278541" ] }, "reaction_10598010": { "compartment": "compartment_12045", "id": "reaction_10598010", "reactome": "R-DDI-1482825", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[11]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426639" ], "products": [ "species_1498733", "species_1524021" ], "modifiers": [ [ "species_10597959", "catalyst" ] ], "additional_components": [ "DDB_G0284449" ] }, "reaction_10597965": { "compartment": "compartment_12045", "id": "reaction_10597965", "reactome": "R-DDI-1482626", "name": "2-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498737", "species_1500578" ], "products": [ "species_426639", "species_76194" ], "modifiers": [ [ "species_10597951", "catalyst" ] ], "additional_components": [ "DDB_G0278541" ] }, "reaction_10598021": { "compartment": "compartment_12045", "id": "reaction_10598021", "reactome": "R-DDI-1482884", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500581" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10597959", "catalyst" ] ], "additional_components": [ "DDB_G0284449" ] }, "reaction_10598023": { "compartment": "compartment_12045", "id": "reaction_10598023", "reactome": "R-DDI-1482887", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500581" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10598004", "catalyst" ] ], "additional_components": [ "DDB_G0283551" ] }, "reaction_10597980": { "compartment": "compartment_12045", "id": "reaction_10597980", "reactome": "R-DDI-1482646", "name": "2-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498729", "species_1500578" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10597977", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541", "Q54X10", "DDB_G0279277" ] }, "reaction_10597983": { "compartment": "compartment_12045", "id": "reaction_10597983", "reactome": "R-DDI-1482667", "name": "1-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498738" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10597977", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541", "Q54X10", "DDB_G0279277" ] }, "reaction_10597988": { "compartment": "compartment_12045", "id": "reaction_10597988", "reactome": "R-DDI-1482691", "name": "2-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498722" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10597972", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541", "Q54X10", "DDB_G0279277" ] }, "reaction_10597975": { "compartment": "compartment_12045", "id": "reaction_10597975", "reactome": "R-DDI-1482636", "name": "1-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498724" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10597972", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541", "Q54X10", "DDB_G0279277" ] }, "reaction_10620264": { "compartment": "compartment_12045", "id": "reaction_10620264", "reactome": "R-DDI-8867876", "name": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_392417", "species_1500646" ], "products": [ "species_33625", "species_1806234" ], "modifiers": [ [ "species_10620261", "catalyst" ] ], "additional_components": [ "Q86KG4", "DDB_G0272498", "Q54RM1", "DDB_G0283035", "Q54NM4", "DDB_G0285141", "Q55CR3", "DDB_G0269938", "Q55CR2", "DDB_G0269940", "Q86HV4", "DDB_G0276427", "Q86HL8", "DDB_G0274517", "Q54EF5", "DDB_G0291562", "Q8MPQ7", "DDB_G0280053" ] }, "reaction_10601149": { "compartment": "compartment_1598585", "id": "reaction_10601149", "reactome": "R-DDI-2470935", "name": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2537690", "species_10601101", "species_10601141" ], "products": [ "species_10601147" ], "modifiers": [], "additional_components": [ "Q54QR0", "DDB_G0283681", "Q54E85", "DDB_G0291752", "Q552D9", "DDB_G0276101", "Q550H7", "DDB_G0276977", "Q552Q7", "DDB_G0275929", "Q54RK7", "DDB_G0283099", "Q54S35", "DDB_G0282689", "Q54RK7", "DDB_G0283099", "Q54S35", "DDB_G0282689", "Q54QR0", "DDB_G0283681", "Q54E85", "DDB_G0291752", "Q552D9", "DDB_G0276101", "Q550H7", "DDB_G0276977", "Q552Q7", "DDB_G0275929" ] }, "reaction_10626171": { "compartment": "compartment_984", "id": "reaction_10626171", "reactome": "R-DDI-9619024", "name": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_9619052" ], "products": [ "species_8878776", "species_9619021" ], "modifiers": [ [ "species_10611415", "catalyst" ] ], "additional_components": [ "Q54ET7", "DDB_G0291344" ] }, "reaction_10582448": { "compartment": "compartment_7660", "id": "reaction_10582448", "reactome": "R-DDI-77584", "name": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582444", "species_10582432" ], "products": [ "species_10582446" ], "modifiers": [], "additional_components": [ "Q54J82", "DDB_G0288225", "Q75J91", "DDB_G0288225", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54J82", "DDB_G0288225", "Q75J91", "DDB_G0288225" ] }, "reaction_10582469": { "compartment": "compartment_7660", "id": "reaction_10582469", "reactome": "R-DDI-77585", "name": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582446", "species_10582465" ], "products": [ "species_10582467" ], "modifiers": [], "additional_components": [ "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54J82", "DDB_G0288225", "Q75J91", "DDB_G0288225", "Q55A45", "DDB_G0272320", "C7G054", "DDB_G0302414", "Q86L45", "DDB_G0273003", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "C7G054", "DDB_G0302414", "Q86L45", "DDB_G0273003", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q54RX0", "DDB_G0282863", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54J82", "DDB_G0288225", "Q75J91", "DDB_G0288225" ] }, "reaction_10582473": { "compartment": "compartment_7660", "id": "reaction_10582473", "reactome": "R-DDI-77586", "name": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582467" ], "products": [ "species_10582471", "species_10582465" ], "modifiers": [], "additional_components": [ "Q55A45", "DDB_G0272320", "C7G054", "DDB_G0302414", "Q86L45", "DDB_G0273003", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q54RX0", "DDB_G0282863", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54J82", "DDB_G0288225", "Q75J91", "DDB_G0288225", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54J82", "DDB_G0288225", "Q75J91", "DDB_G0288225", "Q55A45", "DDB_G0272320", "C7G054", "DDB_G0302414", "Q86L45", "DDB_G0273003", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q54RX0", "DDB_G0282863" ] }, "reaction_10600404": { "compartment": "compartment_70101", "id": "reaction_10600404", "reactome": "R-DDI-2161549", "name": "PGH2 is reduced to PGF2a by AKR1C3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_265283", "species_29364" ], "products": [ "species_29366", "species_879535" ], "modifiers": [ [ "species_10586594", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10589015": { "compartment": "compartment_70101", "id": "reaction_10589015", "reactome": "R-DDI-265295", "name": "Prostaglandin E synthase isomerizes PGH2 to PGE2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265283" ], "products": [ "species_265287" ], "modifiers": [ [ "species_10589012", "catalyst" ] ], "additional_components": [ "DDB_G0268042" ] }, "reaction_10600407": { "compartment": "compartment_70101", "id": "reaction_10600407", "reactome": "R-DDI-2161614", "name": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_879629" ], "products": [ "species_29366", "species_2142710" ], "modifiers": [ [ "species_10586594", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10583842": { "compartment": "compartment_5460", "id": "reaction_10583842", "reactome": "R-DDI-159567", "name": "salicylic acid + Coenzyme A + ATP => salicylate-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_159559" ], "products": [ "species_159448", "species_159450", "species_159557" ], "modifiers": [ [ "species_10583839", "catalyst" ] ], "additional_components": [ "Q8SSN6", "DDB_G0276337", "Q551W4", "DDB_G0276337" ] }, "reaction_10585793": { "compartment": "compartment_5460", "id": "reaction_10585793", "reactome": "R-DDI-177157", "name": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_177153" ], "products": [ "species_159448", "species_159450", "species_177137" ], "modifiers": [ [ "species_10583822", "catalyst" ] ], "additional_components": [ "Q8SSN6", "DDB_G0276337", "Q551W4", "DDB_G0276337" ] }, "reaction_10583825": { "compartment": "compartment_5460", "id": "reaction_10583825", "reactome": "R-DDI-159443", "name": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_159446" ], "products": [ "species_159448", "species_159450", "species_159447" ], "modifiers": [ [ "species_10583822", "catalyst" ] ], "additional_components": [ "Q8SSN6", "DDB_G0276337", "Q551W4", "DDB_G0276337" ] }, "reaction_10625238": { "compartment": "compartment_74700", "id": "reaction_10625238", "reactome": "R-DDI-9018774", "name": "RHOBTB1 binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10625234" ], "products": [ "species_10625236" ], "modifiers": [], "additional_components": [ "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "species_29438" ] }, "reaction_10625269": { "compartment": "compartment_876", "id": "reaction_10625269", "reactome": "R-DDI-9018778", "name": "RHOBTB1 binds interacting proteins at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625236", "species_10625265" ], "products": [ "species_10625267" ], "modifiers": [], "additional_components": [ "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "species_29438", "Q54NZ5", "DDB_G0284903", "B0G0Y8", "DDB_G0268634", "Q54NZ5", "DDB_G0284903", "B0G0Y8", "DDB_G0268634", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "species_29438" ] }, "reaction_10625322": { "compartment": "compartment_74700", "id": "reaction_10625322", "reactome": "R-DDI-9018787", "name": "RHOBTB2 binds interacting proteins at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625307", "species_10625318" ], "products": [ "species_10625320" ], "modifiers": [], "additional_components": [ "P34150", "DDB_G0291976", "P34149", "DDB_G0293526", "Q23862", "DDB_G0280975", "Q1ZXJ6", "DDB_G0278011", "Q54N82", "DDB_G0285453", "Q54HZ7", "DDB_G0289103", "Q9GPQ8", "DDB_G0292816", "Q54YY4", "DDB_G0278009", "Q9GPR7", "DDB_G0269240", "Q9GPQ9", "DDB_G0292560", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "P34148", "DDB_G0279605", "P34146", "DDB_G0282365", "species_29438", "Q54NZ5", "DDB_G0284903", "Q54NZ5", "DDB_G0284903", "P34150", "DDB_G0291976", "P34149", "DDB_G0293526", "Q23862", "DDB_G0280975", "Q1ZXJ6", "DDB_G0278011", "Q54N82", "DDB_G0285453", "Q54HZ7", "DDB_G0289103", "Q9GPQ8", "DDB_G0292816", "Q54YY4", "DDB_G0278009", "Q9GPR7", "DDB_G0269240", "Q9GPQ9", "DDB_G0292560", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "P34148", "DDB_G0279605", "P34146", "DDB_G0282365", "species_29438" ] }, "reaction_10625366": { "compartment": "compartment_876", "id": "reaction_10625366", "reactome": "R-DDI-9018794", "name": "RHOV binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625360", "species_10625362" ], "products": [ "species_10625364" ], "modifiers": [], "additional_components": [ "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "species_29438", "Q55DD4", "DDB_G0269696", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q55DD4", "DDB_G0269696", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "species_29438" ] }, "reaction_10625370": { "compartment": "compartment_876", "id": "reaction_10625370", "reactome": "R-DDI-9018798", "name": "RHOV binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10625368" ], "products": [ "species_29420", "species_10625360" ], "modifiers": [], "additional_components": [ "species_29420", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "species_29438" ] }, "reaction_10627382": { "compartment": "compartment_876", "id": "reaction_10627382", "reactome": "R-DDI-9691168", "name": "RAC1 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583374" ], "products": [ "species_10605813" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10624907": { "compartment": "compartment_876", "id": "reaction_10624907", "reactome": "R-DDI-9013145", "name": "RAC1 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583374", "species_10624903" ], "products": [ "species_10624905" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "Q54WW0", "DDB_G0290421", "Q54G40", "DDB_G0290421", "Q867X6", "DDB_G0267460", "Q86GL4", "DDB_G0287101", "Q54F44", "DDB_G0291117", "Q867T7", "DDB_G0288773", "Q869Q3", "DDB_G0274519", "Q55FT9", "DDB_G0267956", "Q54X65", "DDB_G0279175", "Q6UK63", "DDB_G0287855", "Q55DD4", "DDB_G0269696", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q54I34", "DDB_G0289033", "Q54K32", "DDB_G0287585", "O00899", "DDB_G0269140", "Q54Z25", "DDB_G0277949", "Q54WR4", "DDB_G0279483", "Q54Q49", "DDB_G0284155", "Q54UK0", "DDB_G0281031", "Q9XYS3", "DDB_G0289653", "Q54WW0", "DDB_G0290421", "Q54G40", "DDB_G0290421", "Q867X6", "DDB_G0267460", "Q86GL4", "DDB_G0287101", "Q54F44", "DDB_G0291117", "Q867T7", "DDB_G0288773", "Q869Q3", "DDB_G0274519", "Q55FT9", "DDB_G0267956", "Q54X65", "DDB_G0279175", "Q6UK63", "DDB_G0287855", "Q55DD4", "DDB_G0269696", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q54I34", "DDB_G0289033", "Q54K32", "DDB_G0287585", "O00899", "DDB_G0269140", "Q54Z25", "DDB_G0277949", "Q54WR4", "DDB_G0279483", "Q54Q49", "DDB_G0284155", "Q54UK0", "DDB_G0281031", "Q9XYS3", "DDB_G0289653", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10624927": { "compartment": "compartment_876", "id": "reaction_10624927", "reactome": "R-DDI-9013147", "name": "RAC1 GDIs block activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599930", "species_10624923" ], "products": [ "species_10624925" ], "modifiers": [], "additional_components": [ "species_29420", "P34144", "DDB_G0277869", "Q95UP9", "DDB_G0280049", "Q95UQ1", "DDB_G0291077", "Q95UP9", "DDB_G0280049", "Q95UQ1", "DDB_G0291077", "P34144", "DDB_G0277869", "species_29420" ] }, "reaction_10624700": { "compartment": "compartment_876", "id": "reaction_10624700", "reactome": "R-DDI-9013143", "name": "RAC1 GEFs activate RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10599930" ], "products": [ "species_10583374", "species_29420" ], "modifiers": [ [ "species_10624697", "catalyst" ] ], "additional_components": [ "species_29420", "P34144", "DDB_G0277869", "P34144", "DDB_G0277869", "species_29438", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "Q54LN3", "DDB_G0286543", "Q55BQ8", "DDB_G0292004", "Q54DS6", "DDB_G0291974", "Q54DW1", "DDB_G0292004", "Q54PB7", "DDB_G0292004", "Q54SG9", "DDB_G0282475", "Q54BV5", "DDB_G0293396", "Q54YP1", "DDB_G0293396", "Q54XW8", "DDB_G0278703", "Q54C56", "DDB_G0293396", "Q55DL8", "DDB_G0293396", "Q54BY9", "DDB_G0293396", "Q54YZ6", "DDB_G0277987", "Q54F88", "DDB_G0293396", "Q86HN1", "DDB_G0293396", "Q54DW7", "DDB_G0293396", "Q55G61", "DDB_G0268354", "Q54GP2", "DDB_G0293396", "Q54G10", "DDB_G0293396", "Q86K95", "DDB_G0293396", "Q54NG0", "DDB_G0293396", "Q54J14", "DDB_G0288377", "Q54P81", "DDB_G0293396", "Q54P24", "DDB_G0284845", "Q54SR5", "DDB_G0293396", "Q54S15", "DDB_G0293396", "Q54XA7", "DDB_G0293396", "Q54VX2", "DDB_G0293396", "Q54L90", "DDB_G0286773", "Q54WL2", "DDB_G0279569", "Q552M5", "DDB_G0276019", "Q86G47", "DDB_G0289665", "Q8IS18", "DDB_G0269252", "Q8IS19", "DDB_G0289667", "Q8SSQ3", "DDB_G0274607" ] }, "reaction_10624829": { "compartment": "compartment_876", "id": "reaction_10624829", "reactome": "R-DDI-9013144", "name": "RAC1 GAPs stimulate RAC1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583374", "species_29356" ], "products": [ "species_29372", "species_10599930" ], "modifiers": [ [ "species_10624826", "catalyst" ] ], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "species_29420", "P34144", "DDB_G0277869", "Q54BP9", "DDB_G0293510", "Q1ZXE1", "DDB_G0287895", "Q54E35", "DDB_G0291840", "Q54BF1", "DDB_G0293654", "Q86B03", "DDB_G0276833", "Q54PG5", "DDB_G0284571", "Q54FG5", "DDB_G0290873", "Q86I31", "DDB_G0275085", "Q54XE8", "DDB_G0279009", "Q553X3", "DDB_G0275185", "Q54MV3", "DDB_G0285641", "Q86IG9", "DDB_G0272694" ] }, "reaction_10624960": { "compartment": "compartment_70101", "id": "reaction_10624960", "reactome": "R-DDI-9014293", "name": "RAC2 GDIs block activation of RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624954", "species_10624919" ], "products": [ "species_10624958" ], "modifiers": [], "additional_components": [ "Q54N82", "DDB_G0285453", "P34148", "DDB_G0279605", "Q54YY4", "DDB_G0278009", "P34149", "DDB_G0293526", "Q9GPQ8", "DDB_G0292816", "P34144", "DDB_G0277869", "P34150", "DDB_G0291976", "Q9GPQ9", "DDB_G0292560", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q23862", "DDB_G0280975", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "Q54HZ7", "DDB_G0289103", "P34146", "DDB_G0282365", "Q9GPS3", "DDB_G0276967", "species_29420", "Q95UP9", "DDB_G0280049", "Q95UQ1", "DDB_G0291077", "Q95UP9", "DDB_G0280049", "Q95UQ1", "DDB_G0291077", "Q9GPQ9", "DDB_G0292560", "Q9GPR7", "DDB_G0269240", "Q9GPS0", "DDB_G0269178", "Q9GPS3", "DDB_G0276967", "O96390", "DDB_G0269176", "P34144", "DDB_G0277869", "P34145", "DDB_G0268622", "P34146", "DDB_G0282365", "P34148", "DDB_G0279605", "P34149", "DDB_G0293526", "P34150", "DDB_G0291976", "Q1ZXJ6", "DDB_G0278011", "Q23862", "DDB_G0280975", "Q54HZ7", "DDB_G0289103", "Q54N82", "DDB_G0285453", "Q54YY4", "DDB_G0278009", "Q9GPQ8", "DDB_G0292816", "species_29420" ] }, "reaction_10624982": { "compartment": "compartment_876", "id": "reaction_10624982", "reactome": "R-DDI-9014420", "name": "RAC2 translocates to the phagocytic vesicle membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583458" ], "products": [ "species_10606729" ], "modifiers": [], "additional_components": [ "Q54N82", "DDB_G0285453", "P34148", "DDB_G0279605", "Q54YY4", "DDB_G0278009", "P34149", "DDB_G0293526", "Q9GPQ8", "DDB_G0292816", "P34144", "DDB_G0277869", "P34150", "DDB_G0291976", "Q9GPQ9", "DDB_G0292560", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q23862", "DDB_G0280975", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "Q54HZ7", "DDB_G0289103", "P34146", "DDB_G0282365", "Q9GPS3", "DDB_G0276967", "species_29438", "Q9GPR7", "DDB_G0269240", "Q9GPS0", "DDB_G0269178", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34144", "DDB_G0277869", "P34145", "DDB_G0268622", "P34146", "DDB_G0282365", "P34148", "DDB_G0279605", "P34149", "DDB_G0293526", "P34150", "DDB_G0291976", "Q1ZXJ6", "DDB_G0278011", "Q23862", "DDB_G0280975", "Q54HZ7", "DDB_G0289103", "Q54N82", "DDB_G0285453", "Q54YY4", "DDB_G0278009", "Q9GPQ8", "DDB_G0292816", "Q9GPQ9", "DDB_G0292560", "species_29438" ] }, "reaction_10627542": { "compartment": "compartment_876", "id": "reaction_10627542", "reactome": "R-DDI-9714480", "name": "RAC2 translocates to the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583458" ], "products": [ "species_10627524" ], "modifiers": [], "additional_components": [ "Q54N82", "DDB_G0285453", "P34148", "DDB_G0279605", "Q54YY4", "DDB_G0278009", "P34149", "DDB_G0293526", "Q9GPQ8", "DDB_G0292816", "P34144", "DDB_G0277869", "P34150", "DDB_G0291976", "Q9GPQ9", "DDB_G0292560", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q23862", "DDB_G0280975", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "Q54HZ7", "DDB_G0289103", "P34146", "DDB_G0282365", "Q9GPS3", "DDB_G0276967", "species_29438", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "species_29438" ] }, "reaction_10624980": { "compartment": "compartment_70101", "id": "reaction_10624980", "reactome": "R-DDI-9014296", "name": "RAC2 GEFs activate RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10624954" ], "products": [ "species_29420", "species_10583458" ], "modifiers": [ [ "species_10624977", "catalyst" ] ], "additional_components": [ "Q54N82", "DDB_G0285453", "P34148", "DDB_G0279605", "Q54YY4", "DDB_G0278009", "P34149", "DDB_G0293526", "Q9GPQ8", "DDB_G0292816", "P34144", "DDB_G0277869", "P34150", "DDB_G0291976", "Q9GPQ9", "DDB_G0292560", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q23862", "DDB_G0280975", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "Q54HZ7", "DDB_G0289103", "P34146", "DDB_G0282365", "Q9GPS3", "DDB_G0276967", "species_29420", "Q54N82", "DDB_G0285453", "P34148", "DDB_G0279605", "Q54YY4", "DDB_G0278009", "P34149", "DDB_G0293526", "Q9GPQ8", "DDB_G0292816", "P34144", "DDB_G0277869", "P34150", "DDB_G0291976", "Q9GPQ9", "DDB_G0292560", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q23862", "DDB_G0280975", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "Q54HZ7", "DDB_G0289103", "P34146", "DDB_G0282365", "Q9GPS3", "DDB_G0276967", "species_29438", "Q54SG9", "DDB_G0282475", "Q54LN3", "DDB_G0286543", "Q54PB7", "DDB_G0292004" ] }, "reaction_10627540": { "compartment": "compartment_17906", "id": "reaction_10627540", "reactome": "R-DDI-9714477", "name": "RAC2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627524", "species_10627536" ], "products": [ "species_10627538" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "species_29438", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "species_29438" ] }, "reaction_10624970": { "compartment": "compartment_70101", "id": "reaction_10624970", "reactome": "R-DDI-9014294", "name": "RAC2 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624966", "species_10583458" ], "products": [ "species_10624968" ], "modifiers": [], "additional_components": [ "Q54K32", "DDB_G0287585", "Q54Z25", "DDB_G0277949", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "Q54N82", "DDB_G0285453", "P34148", "DDB_G0279605", "Q54YY4", "DDB_G0278009", "P34149", "DDB_G0293526", "Q9GPQ8", "DDB_G0292816", "P34144", "DDB_G0277869", "P34150", "DDB_G0291976", "Q9GPQ9", "DDB_G0292560", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q23862", "DDB_G0280975", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "Q54HZ7", "DDB_G0289103", "P34146", "DDB_G0282365", "Q9GPS3", "DDB_G0276967", "species_29438", "Q54N82", "DDB_G0285453", "P34148", "DDB_G0279605", "Q54YY4", "DDB_G0278009", "P34149", "DDB_G0293526", "Q9GPQ8", "DDB_G0292816", "P34144", "DDB_G0277869", "P34150", "DDB_G0291976", "Q9GPQ9", "DDB_G0292560", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q23862", "DDB_G0280975", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "Q54HZ7", "DDB_G0289103", "P34146", "DDB_G0282365", "Q9GPS3", "DDB_G0276967", "species_29438", "Q54K32", "DDB_G0287585", "Q54Z25", "DDB_G0277949", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459" ] }, "reaction_10624975": { "compartment": "compartment_70101", "id": "reaction_10624975", "reactome": "R-DDI-9014295", "name": "RAC2 GAPs stimulate RAC2 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10583458" ], "products": [ "species_29372", "species_10624954" ], "modifiers": [ [ "species_10624972", "catalyst" ] ], "additional_components": [ "Q54N82", "DDB_G0285453", "P34148", "DDB_G0279605", "Q54YY4", "DDB_G0278009", "P34149", "DDB_G0293526", "Q9GPQ8", "DDB_G0292816", "P34144", "DDB_G0277869", "P34150", "DDB_G0291976", "Q9GPQ9", "DDB_G0292560", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q23862", "DDB_G0280975", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "Q54HZ7", "DDB_G0289103", "P34146", "DDB_G0282365", "Q9GPS3", "DDB_G0276967", "species_29438", "Q54N82", "DDB_G0285453", "P34148", "DDB_G0279605", "Q54YY4", "DDB_G0278009", "P34149", "DDB_G0293526", "Q9GPQ8", "DDB_G0292816", "P34144", "DDB_G0277869", "P34150", "DDB_G0291976", "Q9GPQ9", "DDB_G0292560", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q23862", "DDB_G0280975", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "Q54HZ7", "DDB_G0289103", "P34146", "DDB_G0282365", "Q9GPS3", "DDB_G0276967", "species_29420", "Q54FF4", "DDB_G0290891", "Q8SSN9", "DDB_G0274243", "Q54TH9", "DDB_G0281739", "Q54XT6", "DDB_G0278755", "Q54J98", "DDB_G0288205", "Q55DW9", "DDB_G0269496", "Q54ND2", "DDB_G0285391" ] }, "reaction_10627580": { "compartment": "compartment_876", "id": "reaction_10627580", "reactome": "R-DDI-9714483", "name": "RAC2 translocates to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583458" ], "products": [ "species_10627578" ], "modifiers": [], "additional_components": [ "Q54N82", "DDB_G0285453", "P34148", "DDB_G0279605", "Q54YY4", "DDB_G0278009", "P34149", "DDB_G0293526", "Q9GPQ8", "DDB_G0292816", "P34144", "DDB_G0277869", "P34150", "DDB_G0291976", "Q9GPQ9", "DDB_G0292560", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q23862", "DDB_G0280975", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "Q54HZ7", "DDB_G0289103", "P34146", "DDB_G0282365", "Q9GPS3", "DDB_G0276967", "species_29438", "P34150", "DDB_G0291976", "P34149", "DDB_G0293526", "Q23862", "DDB_G0280975", "Q1ZXJ6", "DDB_G0278011", "Q54N82", "DDB_G0285453", "Q54HZ7", "DDB_G0289103", "Q9GPQ8", "DDB_G0292816", "Q54YY4", "DDB_G0278009", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "Q9GPQ9", "DDB_G0292560", "Q9GPS3", "DDB_G0276967", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "O96390", "DDB_G0269176", "P34148", "DDB_G0279605", "P34146", "DDB_G0282365", "species_29438" ] }, "reaction_10625394": { "compartment": "compartment_876", "id": "reaction_10625394", "reactome": "R-DDI-9018807", "name": "RAC3 GDIs block activation of RAC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625388", "species_10625374" ], "products": [ "species_10625392" ], "modifiers": [], "additional_components": [ "species_29420", "P34147", "DDB_G0286555", "P34147", "DDB_G0286555", "species_29420" ] }, "reaction_10627586": { "compartment": "compartment_876", "id": "reaction_10627586", "reactome": "R-DDI-9714694", "name": "RAC3 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625376" ], "products": [ "species_10627584" ], "modifiers": [], "additional_components": [ "species_29438", "P34147", "DDB_G0286555", "P34147", "DDB_G0286555", "species_29438" ] }, "reaction_10625381": { "compartment": "compartment_876", "id": "reaction_10625381", "reactome": "R-DDI-9018804", "name": "RAC3 GEFs activate RAC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10625374" ], "products": [ "species_29420", "species_10625376" ], "modifiers": [ [ "species_10625378", "catalyst" ] ], "additional_components": [ "species_29420", "P34147", "DDB_G0286555", "species_29438", "P34147", "DDB_G0286555", "Q54SG9", "DDB_G0282475" ] }, "reaction_10625386": { "compartment": "compartment_876", "id": "reaction_10625386", "reactome": "R-DDI-9018806", "name": "RAC3 GAPs stimulate RAC3 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10625376" ], "products": [ "species_29372", "species_10625374" ], "modifiers": [ [ "species_10625383", "catalyst" ] ], "additional_components": [ "species_29438", "P34147", "DDB_G0286555", "species_29420", "P34147", "DDB_G0286555", "Q54FF4", "DDB_G0290891", "Q8SSN9", "DDB_G0274243", "Q54TH9", "DDB_G0281739", "Q54XT6", "DDB_G0278755", "Q54J98", "DDB_G0288205", "Q55DW9", "DDB_G0269496", "Q54ND2", "DDB_G0285391", "Q54BF1", "DDB_G0293654", "Q86B03", "DDB_G0276833", "Q54PG5", "DDB_G0284571", "Q54E35", "DDB_G0291840", "Q54FG5", "DDB_G0290873", "Q86I31", "DDB_G0275085", "Q54XE8", "DDB_G0279009", "Q553X3", "DDB_G0275185", "Q54MV3", "DDB_G0285641", "Q86IG9", "DDB_G0272694" ] }, "reaction_10625404": { "compartment": "compartment_876", "id": "reaction_10625404", "reactome": "R-DDI-9018808", "name": "RAC3 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625400", "species_10625376" ], "products": [ "species_10625402" ], "modifiers": [], "additional_components": [ "Q867X6", "DDB_G0267460", "Q86GL4", "DDB_G0287101", "Q54F44", "DDB_G0291117", "Q867T7", "DDB_G0288773", "Q869Q3", "DDB_G0274519", "Q55FT9", "DDB_G0267956", "Q54X65", "DDB_G0279175", "Q6UK63", "DDB_G0287855", "Q9XYS3", "DDB_G0289653", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459", "species_29438", "P34147", "DDB_G0286555", "species_29438", "P34147", "DDB_G0286555", "Q867X6", "DDB_G0267460", "Q86GL4", "DDB_G0287101", "Q54F44", "DDB_G0291117", "Q867T7", "DDB_G0288773", "Q869Q3", "DDB_G0274519", "Q55FT9", "DDB_G0267956", "Q54X65", "DDB_G0279175", "Q6UK63", "DDB_G0287855", "Q9XYS3", "DDB_G0289653", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459" ] }, "reaction_10625193": { "compartment": "compartment_876", "id": "reaction_10625193", "reactome": "R-DDI-9018766", "name": "RHOU binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625189", "species_10625172" ], "products": [ "species_10625191" ], "modifiers": [], "additional_components": [ "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "species_29438", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "species_29438", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459" ] }, "reaction_10625198": { "compartment": "compartment_876", "id": "reaction_10625198", "reactome": "R-DDI-9018768", "name": "RHOU auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10625195" ], "products": [ "species_29420", "species_10625172" ], "modifiers": [ [ "species_10625195", "catalyst" ] ], "additional_components": [ "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "species_29420", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "species_29438", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "species_29420" ] }, "reaction_10625079": { "compartment": "compartment_876", "id": "reaction_10625079", "reactome": "R-DDI-9018756", "name": "RHOH binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10625063" ], "products": [ "species_10625065" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "species_29438" ] }, "reaction_10625077": { "compartment": "compartment_876", "id": "reaction_10625077", "reactome": "R-DDI-9018754", "name": "GDIs bind RHOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625065", "species_10625073" ], "products": [ "species_10625075" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "species_29438", "Q95UP9", "DDB_G0280049", "Q95UQ1", "DDB_G0291077", "Q95UP9", "DDB_G0280049", "Q95UQ1", "DDB_G0291077", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "species_29438" ] }, "reaction_10625134": { "compartment": "compartment_876", "id": "reaction_10625134", "reactome": "R-DDI-9018758", "name": "RHOH binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625065", "species_10625130" ], "products": [ "species_10625132" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "species_29438", "Q55DD4", "DDB_G0269696", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q55DD4", "DDB_G0269696", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "species_29438" ] }, "reaction_10605858": { "compartment": "compartment_876", "id": "reaction_10605858", "reactome": "R-DDI-5626549", "name": "IQGAPs bind CALM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605847", "species_10587556" ], "products": [ "species_10605853" ], "modifiers": [], "additional_components": [ "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "Q54K32", "DDB_G0287585", "P34144", "DDB_G0277869", "species_29438", "Q7Z2B8", "DDB_G0277917", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "species_74112", "Q7Z2B8", "DDB_G0277917", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "species_74112", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "Q54K32", "DDB_G0287585", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10605849": { "compartment": "compartment_70101", "id": "reaction_10605849", "reactome": "R-DDI-5626469", "name": "GTP-bound RAC1 and CDC42 bind IQGAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583374", "species_10605845" ], "products": [ "species_10605847" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "Q54K32", "DDB_G0287585", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "Q54K32", "DDB_G0287585", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10605855": { "compartment": "compartment_70101", "id": "reaction_10605855", "reactome": "R-DDI-5626507", "name": "IQGAPs bind F-actin, which is inhibited by calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599576", "species_10605847" ], "products": [ "species_10605851" ], "modifiers": [ [ "species_10605853", "inhibitor" ] ], "additional_components": [ "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54L54", "DDB_G0286893", "species_113592", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "Q54K32", "DDB_G0287585", "P34144", "DDB_G0277869", "species_29438", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "Q54K32", "DDB_G0287585", "P34144", "DDB_G0277869", "species_29438", "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54L54", "DDB_G0286893", "species_113592", "Q7Z2B8", "DDB_G0277917", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "species_74112", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "Q54K32", "DDB_G0287585", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10606803": { "compartment": "compartment_70101", "id": "reaction_10606803", "reactome": "R-DDI-5668932", "name": "PAK2 phosphorylates myosin regulatory light chain (MRLC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606794", "species_113592" ], "products": [ "species_29370", "species_10606800" ], "modifiers": [ [ "species_10605892", "catalyst" ] ], "additional_components": [ "P08799", "DDB_G0286355", "P09402", "DDB_G0277859", "P13833", "DDB_G0276077", "P08799", "DDB_G0286355", "P09402", "DDB_G0277859", "P13833", "DDB_G0276077", "Q869N2", "DDB_G0276459", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450" ] }, "reaction_10624235": { "compartment": "compartment_70101", "id": "reaction_10624235", "reactome": "R-DDI-8981926", "name": "RAC1 and CDC42 activate PAK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590382", "species_10583374" ], "products": [ "species_10590380", "species_10605872" ], "modifiers": [], "additional_components": [ "Q55GV3", "DDB_G0267450", "P34144", "DDB_G0277869", "species_29438", "DDB_G0267450", "Q55GV3", "DDB_G0267450", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10605901": { "compartment": "compartment_70101", "id": "reaction_10605901", "reactome": "R-DDI-5627775", "name": "Autophosphorylation of PAK1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10605874" ], "products": [ "species_10583374", "species_10605898", "species_29370" ], "modifiers": [ [ "species_10605874", "catalyst" ] ], "additional_components": [ "Q55GV3", "DDB_G0267450", "P34144", "DDB_G0277869", "species_29438", "Q55DD4", "DDB_G0269696", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "P34144", "DDB_G0277869", "species_29438", "Q869N2", "DDB_G0276459", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55GV3", "DDB_G0267450", "P34144", "DDB_G0277869", "species_29438", "Q55DD4", "DDB_G0269696", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459" ] }, "reaction_10624237": { "compartment": "compartment_70101", "id": "reaction_10624237", "reactome": "R-DDI-8981931", "name": "RAC1 and CDC42 activate PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583374", "species_10590378" ], "products": [ "species_10605870", "species_10590376" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459", "P34144", "DDB_G0277869", "species_29438", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459" ] }, "reaction_10606784": { "compartment": "compartment_70101", "id": "reaction_10606784", "reactome": "R-DDI-5668731", "name": "NOX3 complex:RAC1:GTP generates superoxide from oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_352327" ], "products": [ "species_70106", "species_29366", "species_3299686" ], "modifiers": [ [ "species_10606781", "catalyst" ] ], "additional_components": [ "Q867X6", "DDB_G0267460", "Q9XYS3", "DDB_G0289653", "Q54F44", "DDB_G0291117", "Q86GL4", "DDB_G0287101", "Q867T7", "DDB_G0288773", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10606786": { "compartment": "compartment_876", "id": "reaction_10606786", "reactome": "R-DDI-5668735", "name": "RAC1:GTP binds NOX3 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583374", "species_10606779" ], "products": [ "species_10606781" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "Q867X6", "DDB_G0267460", "Q9XYS3", "DDB_G0289653", "Q54F44", "DDB_G0291117", "Q86GL4", "DDB_G0287101", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "Q9XYS3", "DDB_G0289653", "Q54F44", "DDB_G0291117", "Q86GL4", "DDB_G0287101", "Q867T7", "DDB_G0288773", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10606759": { "compartment": "compartment_876", "id": "reaction_10606759", "reactome": "R-DDI-5668714", "name": "RAC1:GTP binds NOX1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583374", "species_10606755" ], "products": [ "species_10606757" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "Q867X6", "DDB_G0267460", "Q86GL4", "DDB_G0287101", "Q54F44", "DDB_G0291117", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "Q86GL4", "DDB_G0287101", "Q54F44", "DDB_G0291117", "Q867T7", "DDB_G0288773", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10606762": { "compartment": "compartment_70101", "id": "reaction_10606762", "reactome": "R-DDI-5668718", "name": "NOX1 complex:RAC1:GTP generates superoxide from oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_352327" ], "products": [ "species_70106", "species_29366", "species_3299686" ], "modifiers": [ [ "species_10606757", "catalyst" ] ], "additional_components": [ "Q867X6", "DDB_G0267460", "Q86GL4", "DDB_G0287101", "Q54F44", "DDB_G0291117", "Q867T7", "DDB_G0288773", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10613711": { "compartment": "compartment_1222693", "id": "reaction_10613711", "reactome": "R-DDI-6798174", "name": "PIK3C3:PIK3R4 phosphorylates PI to PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524165" ], "products": [ "species_1629751", "species_29370" ], "modifiers": [ [ "species_10613708", "catalyst" ] ], "additional_components": [ "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627" ] }, "reaction_10627463": { "compartment": "compartment_263163", "id": "reaction_10627463", "reactome": "R-DDI-9706390", "name": "RHOBTB3 binds interacting proteins at trans-Golgi network", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627457", "species_10627459" ], "products": [ "species_10627461" ], "modifiers": [], "additional_components": [ "species_113592", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "P36411", "DDB_G0269236", "Q54FK8", "DDB_G0290829", "Q1ZXB9", "DDB_G0290831", "Q1ZXB8", "DDB_G0294571", "Q552H0", "DDB_G0294571", "Q54FK4", "DDB_G0290833", "Q54FK2", "DDB_G0290793", "Q54FK7", "DDB_G0290779", "Q54FK5", "DDB_G0290789", "Q54NZ5", "DDB_G0284903", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "P36411", "DDB_G0269236", "Q54FK8", "DDB_G0290829", "Q1ZXB9", "DDB_G0290831", "Q1ZXB8", "DDB_G0294571", "Q552H0", "DDB_G0294571", "Q54FK4", "DDB_G0290833", "Q54FK2", "DDB_G0290793", "Q54FK7", "DDB_G0290779", "Q54FK5", "DDB_G0290789", "Q54NZ5", "DDB_G0284903", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "species_113592", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967" ] }, "reaction_10627465": { "compartment": "compartment_263163", "id": "reaction_10627465", "reactome": "R-DDI-9706393", "name": "RHOBTB3 binds ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627455", "species_113592" ], "products": [ "species_10627457" ], "modifiers": [], "additional_components": [ "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "species_113592", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967" ] }, "reaction_10627470": { "compartment": "compartment_263163", "id": "reaction_10627470", "reactome": "R-DDI-9706399", "name": "RHOBTB3 hydrolyzes ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10627457" ], "products": [ "species_29372", "species_10627467" ], "modifiers": [ [ "species_10627457", "catalyst" ] ], "additional_components": [ "species_113592", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "species_29370", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "species_113592", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967" ] }, "reaction_10625434": { "compartment": "compartment_70101", "id": "reaction_10625434", "reactome": "R-DDI-9018826", "name": "RHOT2 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10625411" ], "products": [ "species_29372", "species_10625413" ], "modifiers": [ [ "species_10625411", "catalyst" ] ], "additional_components": [ "Q55G45", "DDB_G0267830", "species_29438", "Q55G45", "DDB_G0267830", "species_29420", "Q55G45", "DDB_G0267830", "species_29438" ] }, "reaction_10625432": { "compartment": "compartment_70101", "id": "reaction_10625432", "reactome": "R-DDI-9018824", "name": "RHOT2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625411", "species_10625426" ], "products": [ "species_10625428" ], "modifiers": [], "additional_components": [ "Q55G45", "DDB_G0267830", "species_29438", "Q9U1M8", "DDB_G0274455", "P54696", "DDB_G0289447", "Q9TW28", "DDB_G0292262", "P54697", "DDB_G0272112", "Q9U1M8", "DDB_G0274455", "P54696", "DDB_G0289447", "Q9TW28", "DDB_G0292262", "P54697", "DDB_G0272112", "Q55G45", "DDB_G0267830", "species_29438" ] }, "reaction_10588961": { "compartment": "compartment_70101", "id": "reaction_10588961", "reactome": "R-DDI-264444", "name": "Autoubiquitination of phospho-COP1(Ser-387 )", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10588954" ], "products": [ "species_10588958" ], "modifiers": [ [ "species_10588954", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0288453", "Q54IY4", "DDB_G0288453", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0288453" ] }, "reaction_10588963": { "compartment": "compartment_70101", "id": "reaction_10588963", "reactome": "R-DDI-264458", "name": "Proteasome mediated degradation of COP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10588958" ], "products": [ "species_10577037" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q54IY4", "DDB_G0288453", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10588956": { "compartment": "compartment_13231", "id": "reaction_10588956", "reactome": "R-DDI-264418", "name": "Translocation of COP1 from the nucleus to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10588952" ], "products": [ "species_10588954" ], "modifiers": [], "additional_components": [ "DDB_G0288453", "DDB_G0288453" ] }, "reaction_10591483": { "compartment": "compartment_7660", "id": "reaction_10591483", "reactome": "R-DDI-427514", "name": "eNoSC deacetylates histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10591466", "species_427523" ], "products": [ "species_427497", "species_427498", "species_10588889" ], "modifiers": [ [ "species_10591480", "catalyst" ] ], "additional_components": [ "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863", "O15819", "DDB_G0267402", "Q54F38", "DDB_G0291185", "Q76NW2", "DDB_G0276863", "Q54CP1", "DDB_G0292960", "Q54GV7", "DDB_G0289967", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863" ] }, "reaction_10591486": { "compartment": "compartment_7660", "id": "reaction_10591486", "reactome": "R-DDI-427527", "name": "eNoSC dimethylates histone H3 at lysine-9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10588889" ], "products": [ "species_77502", "species_10581485" ], "modifiers": [ [ "species_10591480", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "Q54F38", "DDB_G0291185", "Q76NW2", "DDB_G0276863", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863", "Q54CP1", "DDB_G0292960", "Q54GV7", "DDB_G0289967", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863" ] }, "reaction_10596528": { "compartment": "compartment_70101", "id": "reaction_10596528", "reactome": "R-DDI-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10596521" ], "products": [ "species_111294", "species_10596525", "species_10596517", "species_76577" ], "modifiers": [ [ "species_10596448", "catalyst" ] ], "additional_components": [ "Q54ZG5", "DDB_G0277577", "O60999", "DDB_G0291972", "Q75JS0", "DDB_G0272202", "C7G034", "DDB_G0285063", "Q54E43", "DDB_G0291812", "Q557Q0", "DDB_G0291812", "Q55GE4", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q557G6", "DDB_G0291812", "C7G038", "DDB_G0291812", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54JE9", "DDB_G0292128", "Q54QZ3", "DDB_G0292128", "Q75JM9", "DDB_G0292128", "Q54DM4", "DDB_G0292128", "Q54JT8", "DDB_G0292128", "Q54JV0", "DDB_G0292128", "Q54IW6", "DDB_G0292128", "Q54LZ6", "DDB_G0286289", "Q55AE0", "DDB_G0285763", "Q54MZ0", "DDB_G0285763", "Q54PV3", "DDB_G0285763", "Q54TL7", "DDB_G0281679", "Q54KP2", "DDB_G0287221", "Q54GG5", "DDB_G0290179", "Q54QF1", "DDB_G0283983", "Q54XF1", "DDB_G0279003", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q553F3", "DDB_G0275787", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54ZG5", "DDB_G0277577", "O60999", "DDB_G0291972", "Q75JS0", "DDB_G0272202", "C7G034", "DDB_G0285063", "Q54E43", "DDB_G0291812", "Q557Q0", "DDB_G0291812", "Q55GE4", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q557G6", "DDB_G0291812", "C7G038", "DDB_G0291812", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54JE9", "DDB_G0292128", "Q54QZ3", "DDB_G0292128", "Q75JM9", "DDB_G0292128", "Q54DM4", "DDB_G0292128", "Q54JT8", "DDB_G0292128", "Q54JV0", "DDB_G0292128", "Q54IW6", "DDB_G0292128", "Q54LZ6", "DDB_G0286289", "Q55AE0", "DDB_G0285763", "Q54MZ0", "DDB_G0285763", "Q54PV3", "DDB_G0285763", "Q54TL7", "DDB_G0281679", "Q54KP2", "DDB_G0287221", "Q54GG5", "DDB_G0290179", "Q54QF1", "DDB_G0283983", "Q54XF1", "DDB_G0279003", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q553F3", "DDB_G0275787", "Q54ZG5", "DDB_G0277577", "O60999", "DDB_G0291972", "Q75JS0", "DDB_G0272202", "C7G034", "DDB_G0285063", "Q54E43", "DDB_G0291812", "Q557Q0", "DDB_G0291812", "Q55GE4", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q557G6", "DDB_G0291812", "C7G038", "DDB_G0291812", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54JE9", "DDB_G0292128", "Q54QZ3", "DDB_G0292128", "Q75JM9", "DDB_G0292128", "Q54DM4", "DDB_G0292128", "Q54JT8", "DDB_G0292128", "Q54JV0", "DDB_G0292128", "Q54IW6", "DDB_G0292128", "Q54LZ6", "DDB_G0286289", "Q55AE0", "DDB_G0285763", "Q54MZ0", "DDB_G0285763", "Q54PV3", "DDB_G0285763", "Q54TL7", "DDB_G0281679", "Q54KP2", "DDB_G0287221", "Q54GG5", "DDB_G0290179", "Q54QF1", "DDB_G0283983", "Q54XF1", "DDB_G0279003", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586" ] }, "reaction_10596579": { "compartment": "compartment_70101", "id": "reaction_10596579", "reactome": "R-DDI-983147", "name": "Release of E3 from polyubiquitinated substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596577" ], "products": [ "species_983123", "species_10596448" ], "modifiers": [], "additional_components": [ "Q54ZG5", "DDB_G0277577", "O60999", "DDB_G0291972", "Q75JS0", "DDB_G0272202", "C7G034", "DDB_G0285063", "Q54E43", "DDB_G0291812", "Q557Q0", "DDB_G0291812", "Q55GE4", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q557G6", "DDB_G0291812", "C7G038", "DDB_G0291812", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54JE9", "DDB_G0292128", "Q54QZ3", "DDB_G0292128", "Q75JM9", "DDB_G0292128", "Q54DM4", "DDB_G0292128", "Q54JT8", "DDB_G0292128", "Q54JV0", "DDB_G0292128", "Q54IW6", "DDB_G0292128", "Q54LZ6", "DDB_G0286289", "Q55AE0", "DDB_G0285763", "Q54MZ0", "DDB_G0285763", "Q54PV3", "DDB_G0285763", "Q54TL7", "DDB_G0281679", "Q54KP2", "DDB_G0287221", "Q54GG5", "DDB_G0290179", "Q54QF1", "DDB_G0283983", "Q54XF1", "DDB_G0279003", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54ZG5", "DDB_G0277577", "O60999", "DDB_G0291972", "Q75JS0", "DDB_G0272202", "C7G034", "DDB_G0285063", "Q54E43", "DDB_G0291812", "Q557Q0", "DDB_G0291812", "Q55GE4", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q557G6", "DDB_G0291812", "C7G038", "DDB_G0291812", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54JE9", "DDB_G0292128", "Q54QZ3", "DDB_G0292128", "Q75JM9", "DDB_G0292128", "Q54DM4", "DDB_G0292128", "Q54JT8", "DDB_G0292128", "Q54JV0", "DDB_G0292128", "Q54IW6", "DDB_G0292128", "Q54LZ6", "DDB_G0286289", "Q55AE0", "DDB_G0285763", "Q54MZ0", "DDB_G0285763", "Q54PV3", "DDB_G0285763", "Q54TL7", "DDB_G0281679", "Q54KP2", "DDB_G0287221", "Q54GG5", "DDB_G0290179", "Q54QF1", "DDB_G0283983", "Q54XF1", "DDB_G0279003", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586" ] }, "reaction_10596610": { "compartment": "compartment_70101", "id": "reaction_10596610", "reactome": "R-DDI-983152", "name": "Transfer of ubiquitin from E1 to E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596607", "species_10596517" ], "products": [ "species_10596605", "species_10596519" ], "modifiers": [ [ "species_10596517", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q553F3", "DDB_G0275787", "Q553F3", "DDB_G0275787", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q553F3", "DDB_G0275787" ] }, "reaction_10596613": { "compartment": "compartment_70101", "id": "reaction_10596613", "reactome": "R-DDI-983153", "name": "E1 mediated ubiquitin activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596605", "species_10577037", "species_113592", "species_29926" ], "products": [ "species_111294", "species_10596607", "species_29926", "species_76577" ], "modifiers": [ [ "species_10596605", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765" ] }, "reaction_10596581": { "compartment": "compartment_70101", "id": "reaction_10596581", "reactome": "R-DDI-983150", "name": "Proteasomal cleavage of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983123" ], "products": [ "species_10577037", "species_983032", "species_8942986", "species_983036" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10623191": { "compartment": "compartment_70101", "id": "reaction_10623191", "reactome": "R-DDI-8940641", "name": "THOP1 cleaves oligopeptide fragment (8-16aa)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983032" ], "products": [ "species_8955634" ], "modifiers": [ [ "species_10623188", "catalyst" ] ], "additional_components": [ "DDB_G0292362" ] }, "reaction_10596663": { "compartment": "compartment_70101", "id": "reaction_10596663", "reactome": "R-DDI-983162", "name": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983036" ], "products": [ "species_983032", "species_8942986" ], "modifiers": [ [ "species_10596660", "catalyst" ] ], "additional_components": [ "Q557I4", "DDB_G0273419", "Q55CT4", "DDB_G0270994", "Q55CY7", "DDB_G0270670" ] }, "reaction_10596616": { "compartment": "compartment_70101", "id": "reaction_10596616", "reactome": "R-DDI-983156", "name": "Polyubiquitination of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596525", "species_113592", "species_10596519" ], "products": [ "species_111294", "species_10596517", "species_76577", "species_10596577" ], "modifiers": [ [ "species_10596525", "catalyst" ] ], "additional_components": [ "Q54ZG5", "DDB_G0277577", "O60999", "DDB_G0291972", "Q75JS0", "DDB_G0272202", "C7G034", "DDB_G0285063", "Q54E43", "DDB_G0291812", "Q557Q0", "DDB_G0291812", "Q55GE4", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q557G6", "DDB_G0291812", "C7G038", "DDB_G0291812", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54JE9", "DDB_G0292128", "Q54QZ3", "DDB_G0292128", "Q75JM9", "DDB_G0292128", "Q54DM4", "DDB_G0292128", "Q54JT8", "DDB_G0292128", "Q54JV0", "DDB_G0292128", "Q54IW6", "DDB_G0292128", "Q54LZ6", "DDB_G0286289", "Q55AE0", "DDB_G0285763", "Q54MZ0", "DDB_G0285763", "Q54PV3", "DDB_G0285763", "Q54TL7", "DDB_G0281679", "Q54KP2", "DDB_G0287221", "Q54GG5", "DDB_G0290179", "Q54QF1", "DDB_G0283983", "Q54XF1", "DDB_G0279003", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q553F3", "DDB_G0275787", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q553F3", "DDB_G0275787", "Q54ZG5", "DDB_G0277577", "O60999", "DDB_G0291972", "Q75JS0", "DDB_G0272202", "C7G034", "DDB_G0285063", "Q54E43", "DDB_G0291812", "Q557Q0", "DDB_G0291812", "Q55GE4", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q557G6", "DDB_G0291812", "C7G038", "DDB_G0291812", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54JE9", "DDB_G0292128", "Q54QZ3", "DDB_G0292128", "Q75JM9", "DDB_G0292128", "Q54DM4", "DDB_G0292128", "Q54JT8", "DDB_G0292128", "Q54JV0", "DDB_G0292128", "Q54IW6", "DDB_G0292128", "Q54LZ6", "DDB_G0286289", "Q55AE0", "DDB_G0285763", "Q54MZ0", "DDB_G0285763", "Q54PV3", "DDB_G0285763", "Q54TL7", "DDB_G0281679", "Q54KP2", "DDB_G0287221", "Q54GG5", "DDB_G0290179", "Q54QF1", "DDB_G0283983", "Q54XF1", "DDB_G0279003", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54ZG5", "DDB_G0277577", "O60999", "DDB_G0291972", "Q75JS0", "DDB_G0272202", "C7G034", "DDB_G0285063", "Q54E43", "DDB_G0291812", "Q557Q0", "DDB_G0291812", "Q55GE4", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q557G6", "DDB_G0291812", "C7G038", "DDB_G0291812", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54JE9", "DDB_G0292128", "Q54QZ3", "DDB_G0292128", "Q75JM9", "DDB_G0292128", "Q54DM4", "DDB_G0292128", "Q54JT8", "DDB_G0292128", "Q54JV0", "DDB_G0292128", "Q54IW6", "DDB_G0292128", "Q54LZ6", "DDB_G0286289", "Q55AE0", "DDB_G0285763", "Q54MZ0", "DDB_G0285763", "Q54PV3", "DDB_G0285763", "Q54TL7", "DDB_G0281679", "Q54KP2", "DDB_G0287221", "Q54GG5", "DDB_G0290179", "Q54QF1", "DDB_G0283983", "Q54XF1", "DDB_G0279003", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765" ] }, "reaction_10596618": { "compartment": "compartment_70101", "id": "reaction_10596618", "reactome": "R-DDI-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596519", "species_983035", "species_10596448" ], "products": [ "species_10596521" ], "modifiers": [], "additional_components": [ "Q553F3", "DDB_G0275787", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54ZG5", "DDB_G0277577", "O60999", "DDB_G0291972", "Q75JS0", "DDB_G0272202", "C7G034", "DDB_G0285063", "Q54E43", "DDB_G0291812", "Q557Q0", "DDB_G0291812", "Q55GE4", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q557G6", "DDB_G0291812", "C7G038", "DDB_G0291812", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54JE9", "DDB_G0292128", "Q54QZ3", "DDB_G0292128", "Q75JM9", "DDB_G0292128", "Q54DM4", "DDB_G0292128", "Q54JT8", "DDB_G0292128", "Q54JV0", "DDB_G0292128", "Q54IW6", "DDB_G0292128", "Q54LZ6", "DDB_G0286289", "Q55AE0", "DDB_G0285763", "Q54MZ0", "DDB_G0285763", "Q54PV3", "DDB_G0285763", "Q54TL7", "DDB_G0281679", "Q54KP2", "DDB_G0287221", "Q54GG5", "DDB_G0290179", "Q54QF1", "DDB_G0283983", "Q54XF1", "DDB_G0279003", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54ZG5", "DDB_G0277577", "O60999", "DDB_G0291972", "Q75JS0", "DDB_G0272202", "C7G034", "DDB_G0285063", "Q54E43", "DDB_G0291812", "Q557Q0", "DDB_G0291812", "Q55GE4", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q557G6", "DDB_G0291812", "C7G038", "DDB_G0291812", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54JE9", "DDB_G0292128", "Q54QZ3", "DDB_G0292128", "Q75JM9", "DDB_G0292128", "Q54DM4", "DDB_G0292128", "Q54JT8", "DDB_G0292128", "Q54JV0", "DDB_G0292128", "Q54IW6", "DDB_G0292128", "Q54LZ6", "DDB_G0286289", "Q55AE0", "DDB_G0285763", "Q54MZ0", "DDB_G0285763", "Q54PV3", "DDB_G0285763", "Q54TL7", "DDB_G0281679", "Q54KP2", "DDB_G0287221", "Q54GG5", "DDB_G0290179", "Q54QF1", "DDB_G0283983", "Q54XF1", "DDB_G0279003", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q553F3", "DDB_G0275787", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765" ] }, "reaction_10596569": { "compartment": "compartment_17957", "id": "reaction_10596569", "reactome": "R-DDI-983144", "name": "Transport of Antigen peptide in to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_983032" ], "products": [ "species_29372", "species_29370", "species_983034" ], "modifiers": [ [ "species_10596566", "catalyst" ] ], "additional_components": [ "Q54BU4", "DDB_G0293416", "Q8T9W1", "DDB_G0286123", "P54683", "DDB_G0286119", "Q23868", "DDB_G0286121" ] }, "reaction_10596648": { "compartment": "compartment_17957", "id": "reaction_10596648", "reactome": "R-DDI-983158", "name": "Trimming of peptides in ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983034" ], "products": [ "species_8943716", "species_983033" ], "modifiers": [ [ "species_10596645", "catalyst" ] ], "additional_components": [ "Q55CY7", "DDB_G0270670", "Q557I4", "DDB_G0273419", "Q55CT4", "DDB_G0270994" ] }, "reaction_10588094": { "compartment": "compartment_12045", "id": "reaction_10588094", "reactome": "R-DDI-203979", "name": "Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587919", "species_10588090" ], "products": [ "species_10588092" ], "modifiers": [], "additional_components": [ "Q559R0", "DDB_G0272296", "species_29438", "Q54T59", "DDB_G0281985", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q559R0", "DDB_G0272296", "species_29438" ] }, "reaction_10597282": { "compartment": "compartment_70101", "id": "reaction_10597282", "reactome": "R-DDI-1236970", "name": "Proteasomal clevage of exogenous antigen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1236719" ], "products": [ "species_8942986", "species_983036" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10583537": { "compartment": "compartment_876", "id": "reaction_10583537", "reactome": "R-DDI-114688", "name": "PLC-beta hydrolyses PIP2 to DAG and IP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583532" ], "products": [ "species_10583534" ], "modifiers": [ [ "species_10582955", "catalyst" ] ], "additional_components": [ "species_179856", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438", "Q02158", "DDB_G0292736", "species_6797635", "species_114520", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438", "Q02158", "DDB_G0292736", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438", "Q02158", "DDB_G0292736" ] }, "reaction_10624320": { "compartment": "compartment_876", "id": "reaction_10624320", "reactome": "R-DDI-8982026", "name": "G alpha (q):RGS dissociates to inactive G alpha (q)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624315" ], "products": [ "species_10590812", "species_10624295" ], "modifiers": [], "additional_components": [ "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29420", "species_29420", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817" ] }, "reaction_10590869": { "compartment": "compartment_876", "id": "reaction_10590869", "reactome": "R-DDI-418582", "name": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582953" ], "products": [ "species_10590812" ], "modifiers": [ [ "species_10582953", "catalyst" ], [ "species_10590867", "catalyst" ] ], "additional_components": [ "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438", "species_29420", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438", "Q55E55", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817" ] }, "reaction_10624299": { "compartment": "compartment_876", "id": "reaction_10624299", "reactome": "R-DDI-8982017", "name": "Active G alpha (q) binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582953", "species_10624295" ], "products": [ "species_10624297" ], "modifiers": [], "additional_components": [ "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438", "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438" ] }, "reaction_10583555": { "compartment": "compartment_70101", "id": "reaction_10583555", "reactome": "R-DDI-139941", "name": "Binding of IP3 to IP3 receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583548", "species_114520" ], "products": [ "species_10583550" ], "modifiers": [], "additional_components": [ "Q9NA13", "DDB_G0292564", "species_114520", "species_74112", "Q9NA13", "DDB_G0292564" ] }, "reaction_10591430": { "compartment": "compartment_876", "id": "reaction_10591430", "reactome": "R-DDI-426032", "name": "DAG is metabolized by DAGL to 2-AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114519" ], "products": [ "species_426026", "species_426030" ], "modifiers": [ [ "species_10591427", "catalyst" ] ], "additional_components": [ "Q54ET1", "DDB_G0291354", "Q54GX3", "DDB_G0291354", "Q54YL1", "DDB_G0291354" ] }, "reaction_10591452": { "compartment": "compartment_70101", "id": "reaction_10591452", "reactome": "R-DDI-426240", "name": "DAG kinase produces phosphatidic acid from DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_114519" ], "products": [ "species_76108", "species_29370" ], "modifiers": [ [ "species_10591435", "catalyst" ] ], "additional_components": [ "DDB_G0277223" ] }, "reaction_10624318": { "compartment": "compartment_876", "id": "reaction_10624318", "reactome": "R-DDI-8982025", "name": "G alpha (q) in G (q):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624297" ], "products": [ "species_29372", "species_10624315" ], "modifiers": [ [ "species_10624297", "catalyst" ] ], "additional_components": [ "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438", "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29420", "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438" ] }, "reaction_10580531": { "compartment": "compartment_70101", "id": "reaction_10580531", "reactome": "R-DDI-73616", "name": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_83960", "species_29364" ], "products": [ "species_29366", "species_73541" ], "modifiers": [ [ "species_10580469", "catalyst" ] ], "additional_components": [ "Q55FT1", "DDB_G0267966", "species_76629", "species_113596" ] }, "reaction_10580482": { "compartment": "compartment_70101", "id": "reaction_10580482", "reactome": "R-DDI-73589", "name": "5,6-dihydrouracil + H2O => beta-ureidopropionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73584" ], "products": [ "species_73588" ], "modifiers": [ [ "species_10580479", "catalyst" ] ], "additional_components": [ "species_29426", "Q55DL0", "DDB_G0269246" ] }, "reaction_10580533": { "compartment": "compartment_70101", "id": "reaction_10580533", "reactome": "R-DDI-73618", "name": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73541" ], "products": [ "species_73617" ], "modifiers": [ [ "species_10580479", "catalyst" ] ], "additional_components": [ "species_29426", "Q55DL0", "DDB_G0269246" ] }, "reaction_10580535": { "compartment": "compartment_70101", "id": "reaction_10580535", "reactome": "R-DDI-73620", "name": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73617" ], "products": [ "species_113528", "species_73619", "species_31633" ], "modifiers": [ [ "species_10580489", "catalyst" ] ], "additional_components": [ "species_29426", "Q964D8", "DDB_G0274123" ] }, "reaction_10581240": { "compartment": "compartment_70101", "id": "reaction_10581240", "reactome": "R-DDI-74376", "name": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_500430" ], "products": [ "species_83962", "species_500244" ], "modifiers": [ [ "species_10581235", "catalyst" ] ], "additional_components": [ "CHEBI:16450", "CHEBI:16704", "CHEBI:28542", "species_112016", "Q54PM8", "DDB_G0284431" ] }, "reaction_10580472": { "compartment": "compartment_70101", "id": "reaction_10580472", "reactome": "R-DDI-73585", "name": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_83962", "species_29364" ], "products": [ "species_29366", "species_73584" ], "modifiers": [ [ "species_10580469", "catalyst" ] ], "additional_components": [ "Q55FT1", "DDB_G0267966", "species_76629", "species_113596" ] }, "reaction_10580492": { "compartment": "compartment_70101", "id": "reaction_10580492", "reactome": "R-DDI-73591", "name": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73588" ], "products": [ "species_113528", "species_73590", "species_31633" ], "modifiers": [ [ "species_10580489", "catalyst" ] ], "additional_components": [ "species_29426", "Q964D8", "DDB_G0274123" ] }, "reaction_10623846": { "compartment": "compartment_5460", "id": "reaction_10623846", "reactome": "R-DDI-8952873", "name": "MECR dimer reduces tdec2-CoA to DEC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77343", "species_113529", "species_113600" ], "products": [ "species_77308", "species_113563" ], "modifiers": [ [ "species_10623843", "catalyst" ] ], "additional_components": [ "Q54YT4", "DDB_G0278095" ] }, "reaction_10582430": { "compartment": "compartment_5460", "id": "reaction_10582430", "reactome": "R-DDI-77344", "name": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77343", "species_113521" ], "products": [ "species_77341" ], "modifiers": [ [ "species_10578064", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10586368": { "compartment": "compartment_876", "id": "reaction_10586368", "reactome": "R-DDI-190519", "name": "Internalization of gap junction plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10586270", "species_10586248" ], "products": [ "species_10586366" ], "modifiers": [], "additional_components": [ "P54697", "DDB_G0272112", "Q9TW28", "DDB_G0292262", "P54696", "DDB_G0289447", "Q9U1M8", "DDB_G0274455", "P54672", "DDB_G0277139", "P54672", "DDB_G0277139", "P54696", "DDB_G0289447", "P54697", "DDB_G0272112", "Q9TW28", "DDB_G0292262", "Q9U1M8", "DDB_G0274455" ] }, "reaction_10586370": { "compartment": "compartment_70101", "id": "reaction_10586370", "reactome": "R-DDI-190829", "name": "Lysosomal degradation of gap junction plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10586366" ], "products": [], "modifiers": [], "additional_components": [ "P54672", "DDB_G0277139", "P54696", "DDB_G0289447", "P54697", "DDB_G0272112", "Q9TW28", "DDB_G0292262", "Q9U1M8", "DDB_G0274455" ] }, "reaction_10586762": { "compartment": "compartment_876", "id": "reaction_10586762", "reactome": "R-DDI-196017", "name": "Dynamin is recruited to the gap junction plaque", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10586246", "species_10586226" ], "products": [ "species_10586248" ], "modifiers": [], "additional_components": [ "P54672", "DDB_G0277139", "P54672", "DDB_G0277139" ] }, "reaction_10576483": { "compartment": "compartment_7660", "id": "reaction_10576483", "reactome": "R-DDI-68603", "name": "Orc5 associates with Orc3:Orc2:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576479", "species_10576472" ], "products": [ "species_10576481" ], "modifiers": [], "additional_components": [ "DDB_G0293214", "Q55CU7", "DDB_G0269894", "Q55BR6", "DDB_G0271078", "Q55CU7", "DDB_G0269894", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214" ] }, "reaction_10576501": { "compartment": "compartment_7660", "id": "reaction_10576501", "reactome": "R-DDI-68611", "name": "Orc1 associates with Orc4:Orc5:Orc3:Orc2:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576490", "species_10576497" ], "products": [ "species_10576499" ], "modifiers": [], "additional_components": [ "Q55CU7", "DDB_G0269894", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "Q86AD6", "DDB_G0271562", "DDB_G0283073", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "Q86AD6", "DDB_G0271562" ] }, "reaction_10576474": { "compartment": "compartment_7660", "id": "reaction_10576474", "reactome": "R-DDI-68595", "name": "Orc3 associates with Orc2 constitutively bound at origins of replication", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576463", "species_10576470" ], "products": [ "species_10576472" ], "modifiers": [], "additional_components": [ "DDB_G0271078", "Q55CU7", "DDB_G0269894", "Q55CU7", "DDB_G0269894", "Q55BR6", "DDB_G0271078" ] }, "reaction_10576492": { "compartment": "compartment_7660", "id": "reaction_10576492", "reactome": "R-DDI-68610", "name": "Orc4 associates with Orc5:Orc3:Orc2:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576488", "species_10576481" ], "products": [ "species_10576490" ], "modifiers": [], "additional_components": [ "DDB_G0271562", "Q55CU7", "DDB_G0269894", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "Q55CU7", "DDB_G0269894", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "Q86AD6", "DDB_G0271562" ] }, "reaction_10576510": { "compartment": "compartment_7660", "id": "reaction_10576510", "reactome": "R-DDI-68615", "name": "Orc6 associates with Orc1:Orc4:Orc5:Orc3:Orc2:origin complexes, forming ORC:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576506", "species_10576499" ], "products": [ "species_10576508" ], "modifiers": [], "additional_components": [ "DDB_G0284771", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "Q86AD6", "DDB_G0271562", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q86AD6", "DDB_G0271562", "Q54P62", "DDB_G0284771", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214" ] }, "reaction_10600374": { "compartment": "compartment_876", "id": "reaction_10600374", "reactome": "R-DDI-2142859", "name": "Growing HA is extruded from the cell by ABCC5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142896" ], "products": [ "species_2160848" ], "modifiers": [ [ "species_10597751", "catalyst" ] ], "additional_components": [ "species_2162224", "species_2162224", "Q54V86", "DDB_G0280539", "Q8T6H3", "DDB_G0287593", "Q54EK2", "DDB_G0291243", "Q8T6H8", "DDB_G0280541", "Q54K24", "DDB_G0287589", "Q54VC1", "DDB_G0280459", "Q54VJ0", "DDB_G0280055", "Q54NL1", "DDB_G0285165" ] }, "reaction_10611339": { "compartment": "compartment_984", "id": "reaction_10611339", "reactome": "R-DDI-5693356", "name": "CEMIP hydrolyses HA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2160848" ], "products": [ "species_5693343", "species_2160848" ], "modifiers": [ [ "species_10611336", "catalyst" ] ], "additional_components": [ "species_2162224", "species_2162224", "Q54KF6", "DDB_G0287365", "Q55D62", "DDB_G0287365" ] }, "reaction_10616531": { "compartment": "compartment_7660", "id": "reaction_10616531", "reactome": "R-DDI-6802973", "name": "PLK3 phosphorylates CDC25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10581492" ], "products": [ "species_113582", "species_10616519" ], "modifiers": [ [ "species_10616528", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "Q54BR8", "DDB_G0293470", "Q86HN7", "DDB_G0274503" ] }, "reaction_10613702": { "compartment": "compartment_70101", "id": "reaction_10613702", "reactome": "R-DDI-6798044", "name": "BTG2 binds CCR4-NOT complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613698", "species_10613634" ], "products": [ "species_10613700" ], "modifiers": [], "additional_components": [ "Q554L0", "DDB_G0275005", "Q55D59", "DDB_G0269778", "Q54HH3", "DDB_G0289461", "Q54PZ4", "DDB_G0285269", "Q54NG7", "DDB_G0285269", "Q1ZXI2", "DDB_G0279005", "Q75JL4", "DDB_G0276029", "Q54U17", "DDB_G0281363", "Q54PG2", "DDB_G0284577", "Q55AA8", "DDB_G0272056", "DDB_G0285069", "Q54NU5", "DDB_G0285069", "Q554L0", "DDB_G0275005", "Q55D59", "DDB_G0269778", "Q54HH3", "DDB_G0289461", "Q54PZ4", "DDB_G0285269", "Q54NG7", "DDB_G0285269", "Q1ZXI2", "DDB_G0279005", "Q75JL4", "DDB_G0276029", "Q54U17", "DDB_G0281363", "Q54PG2", "DDB_G0284577", "Q55AA8", "DDB_G0272056" ] }, "reaction_10616032": { "compartment": "compartment_70101", "id": "reaction_10616032", "reactome": "R-DDI-6799722", "name": "TP53I3 oxidoreductase generates unstable semiquinones", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_6799725", "species_29364" ], "products": [ "species_6799726", "species_29366" ], "modifiers": [ [ "species_10615972", "catalyst" ] ], "additional_components": [ "Q75JT6", "DDB_G0272440" ] }, "reaction_10616466": { "compartment": "compartment_876", "id": "reaction_10616466", "reactome": "R-DDI-6801101", "name": "RABGGTA binds RABGGTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616462", "species_10616457" ], "products": [ "species_10616464" ], "modifiers": [], "additional_components": [ "DDB_G0290671", "DDB_G0269570", "Q55DQ4", "DDB_G0269570", "B0G172", "DDB_G0290671" ] }, "reaction_10615974": { "compartment": "compartment_70101", "id": "reaction_10615974", "reactome": "R-DDI-6799466", "name": "TP53I3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615970" ], "products": [ "species_10615972" ], "modifiers": [], "additional_components": [ "DDB_G0272440", "Q75JT6", "DDB_G0272440" ] }, "reaction_10616475": { "compartment": "compartment_70101", "id": "reaction_10616475", "reactome": "R-DDI-6801109", "name": "CHM binds RGGT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616471", "species_10616464" ], "products": [ "species_10616473" ], "modifiers": [], "additional_components": [ "DDB_G0280143", "Q55DQ4", "DDB_G0269570", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "B0G172", "DDB_G0290671", "Q54VT9", "DDB_G0280143" ] }, "reaction_10616445": { "compartment": "compartment_70101", "id": "reaction_10616445", "reactome": "R-DDI-6800793", "name": "PIDD1 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616441" ], "products": [ "species_10616443" ], "modifiers": [], "additional_components": [ "DDB_G0284461", "DDB_G0284461" ] }, "reaction_10616491": { "compartment": "compartment_17927", "id": "reaction_10616491", "reactome": "R-DDI-6801242", "name": "TRIAP1 binds PRELID1, PRELID3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616485", "species_10616480" ], "products": [ "species_10616489" ], "modifiers": [], "additional_components": [ "DDB_G0290499", "DDB_G0287279", "Q54KL1", "DDB_G0287279", "Q54G07", "DDB_G0290499" ] }, "reaction_10616494": { "compartment": "compartment_17906", "id": "reaction_10616494", "reactome": "R-DDI-6801250", "name": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500590" ], "products": [ "species_1524101" ], "modifiers": [ [ "species_10616489", "catalyst" ] ], "additional_components": [ "Q54KL1", "DDB_G0287279", "Q54G07", "DDB_G0290499" ] }, "reaction_10613581": { "compartment": "compartment_7660", "id": "reaction_10613581", "reactome": "R-DDI-6797606", "name": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10613565" ], "products": [ "species_113582", "species_10613578" ], "modifiers": [ [ "species_10613565", "catalyst" ] ], "additional_components": [ "Q54LJ0", "DDB_G0286617", "Q75JA4", "DDB_G0271690", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q556Z2", "DDB_G0273207", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54LJ0", "DDB_G0286617", "Q75JA4", "DDB_G0271690", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q556Z2", "DDB_G0273207", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54LJ0", "DDB_G0286617", "Q75JA4", "DDB_G0271690", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q556Z2", "DDB_G0273207", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10613541": { "compartment": "compartment_70101", "id": "reaction_10613541", "reactome": "R-DDI-6795290", "name": "TORC2 complex phosphorylates SGK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613531", "species_113592" ], "products": [ "species_29370", "species_10613539" ], "modifiers": [ [ "species_10587023", "catalyst" ] ], "additional_components": [ "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54D08", "DDB_G0292592", "O77203", "DDB_G0277399", "Q9Y0C9", "DDB_G0284611", "Q86C65", "DDB_G0281569" ] }, "reaction_10613551": { "compartment": "compartment_70101", "id": "reaction_10613551", "reactome": "R-DDI-6795473", "name": "PDPK1 phosphorylates SGK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10613539" ], "products": [ "species_10613549", "species_29370" ], "modifiers": [ [ "species_10582584", "catalyst" ] ], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10577717": { "compartment": "compartment_70101", "id": "reaction_10577717", "reactome": "R-DDI-70377", "name": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30537", "species_29366" ], "products": [ "species_70106", "species_31467", "species_29364" ], "modifiers": [ [ "species_10577714", "catalyst" ] ], "additional_components": [ "species_29366", "Q557D2", "DDB_G0273131" ] }, "reaction_10605925": { "compartment": "compartment_70101", "id": "reaction_10605925", "reactome": "R-DDI-5631885", "name": "PRDX1 overoxidizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605917", "species_29408" ], "products": [ "species_29356", "species_10605922" ], "modifiers": [ [ "species_10605917", "catalyst" ] ], "additional_components": [ "Q555L5", "DDB_G0274859", "Q555L5", "DDB_G0274859", "Q555L5", "DDB_G0274859" ] }, "reaction_10605942": { "compartment": "compartment_70101", "id": "reaction_10605942", "reactome": "R-DDI-5631903", "name": "SESN1,2,3 bind overoxidized PRDX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605922", "species_10605938" ], "products": [ "species_10605940" ], "modifiers": [], "additional_components": [ "Q555L5", "DDB_G0274859", "Q54WU6", "DDB_G0279427", "Q54WU6", "DDB_G0279427", "Q555L5", "DDB_G0274859" ] }, "reaction_10578681": { "compartment": "compartment_70101", "id": "reaction_10578681", "reactome": "R-DDI-71682", "name": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_111745" ], "products": [ "species_29450", "species_29366" ], "modifiers": [ [ "species_10578678", "catalyst" ] ], "additional_components": [ "Q8T137", "DDB_G0272754", "species_113596" ] }, "reaction_10589979": { "compartment": "compartment_70101", "id": "reaction_10589979", "reactome": "R-DDI-380979", "name": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584242" ], "products": [ "species_29372", "species_10589976" ], "modifiers": [ [ "species_10584242", "catalyst" ] ], "additional_components": [ "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318" ] }, "reaction_10586987": { "compartment": "compartment_70101", "id": "reaction_10586987", "reactome": "R-DDI-198609", "name": "AKT phosphorylates TSC2, inhibiting it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584141", "species_113592" ], "products": [ "species_29370", "species_10586984" ], "modifiers": [ [ "species_10586959", "catalyst" ] ], "additional_components": [ "DDB_G0280527", "DDB_G0280527", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795" ] }, "reaction_10605946": { "compartment": "compartment_70101", "id": "reaction_10605946", "reactome": "R-DDI-5631941", "name": "SESN1,2,3 bind AMPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589958", "species_10605938" ], "products": [ "species_10605944" ], "modifiers": [], "additional_components": [ "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "Q54WU6", "DDB_G0279427", "Q54WU6", "DDB_G0279427", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643" ] }, "reaction_10624930": { "compartment": "compartment_5460", "id": "reaction_10624930", "reactome": "R-DDI-9013198", "name": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614595", "species_9013199" ], "products": [ "species_9013207", "species_9013191" ], "modifiers": [ [ "species_10624637", "catalyst" ] ], "additional_components": [ "DDB_G0291816" ] }, "reaction_10617891": { "compartment": "compartment_70101", "id": "reaction_10617891", "reactome": "R-DDI-6814153", "name": "ADO oxidises 2AET to HTAU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_6814151" ], "products": [ "species_1655445", "species_70106" ], "modifiers": [ [ "species_10617888", "catalyst" ] ], "additional_components": [ "species_71067", "Q556I2", "DDB_G0273031" ] }, "reaction_10624640": { "compartment": "compartment_5460", "id": "reaction_10624640", "reactome": "R-DDI-9012721", "name": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9012724", "species_9012592" ], "products": [ "species_1614595", "species_113557" ], "modifiers": [ [ "species_10624637", "catalyst" ] ], "additional_components": [ "DDB_G0291816" ] }, "reaction_10598498": { "compartment": "compartment_70101", "id": "reaction_10598498", "reactome": "R-DDI-1614645", "name": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_29368" ], "products": [ "species_1614519" ], "modifiers": [ [ "species_10598495", "catalyst" ] ], "additional_components": [ "species_71067", "Q54K68", "DDB_G0287555" ] }, "reaction_10624934": { "compartment": "compartment_5460", "id": "reaction_10624934", "reactome": "R-DDI-9013533", "name": "MPST transfers sulfur from sulfanegen to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9013543", "species_9013199" ], "products": [ "species_9013191", "species_113557" ], "modifiers": [ [ "species_10624637", "catalyst" ] ], "additional_components": [ "DDB_G0291816" ] }, "reaction_10624932": { "compartment": "compartment_5460", "id": "reaction_10624932", "reactome": "R-DDI-9013471", "name": "MPST transfers sulfur from 3MPYR to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9012592", "species_9013199" ], "products": [ "species_9013191", "species_113557" ], "modifiers": [ [ "species_10624637", "catalyst" ] ], "additional_components": [ "DDB_G0291816" ] }, "reaction_10598477": { "compartment": "compartment_70101", "id": "reaction_10598477", "reactome": "R-DDI-1614567", "name": "Excess homocysteine yields homolanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369" ], "products": [ "species_1614532", "species_1614594" ], "modifiers": [ [ "species_10598474", "catalyst" ], [ "species_174369", "catalyst" ] ], "additional_components": [ "Q55DV9", "DDB_G0269122" ] }, "reaction_10625805": { "compartment": "compartment_5460", "id": "reaction_10625805", "reactome": "R-DDI-9034756", "name": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624637", "species_9012592" ], "products": [ "species_10625803", "species_113557" ], "modifiers": [ [ "species_10624637", "catalyst" ] ], "additional_components": [ "DDB_G0291816", "DDB_G0291816", "DDB_G0291816" ] }, "reaction_10625811": { "compartment": "compartment_5460", "id": "reaction_10625811", "reactome": "R-DDI-9035484", "name": "CysS248-MPST:TXN2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625807" ], "products": [ "species_10624637", "species_10602636", "species_1655881" ], "modifiers": [], "additional_components": [ "Q54NX3", "DDB_G0284939", "Q54E40", "DDB_G0291816", "DDB_G0291816", "DDB_G0284939" ] }, "reaction_10598483": { "compartment": "compartment_70101", "id": "reaction_10598483", "reactome": "R-DDI-1614591", "name": "Excess cysteine yields lanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707" ], "products": [ "species_1614582", "species_1614532" ], "modifiers": [ [ "species_10598474", "catalyst" ], [ "species_111707", "catalyst" ] ], "additional_components": [ "Q55DV9", "DDB_G0269122" ] }, "reaction_10625809": { "compartment": "compartment_5460", "id": "reaction_10625809", "reactome": "R-DDI-9035227", "name": "TXN2 binds CysS248-MPST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625803", "species_10602633" ], "products": [ "species_10625807" ], "modifiers": [], "additional_components": [ "DDB_G0291816", "DDB_G0284939", "Q54NX3", "DDB_G0284939", "Q54E40", "DDB_G0291816" ] }, "reaction_10598485": { "compartment": "compartment_70101", "id": "reaction_10598485", "reactome": "R-DDI-1614614", "name": "Cysteine is degraded to serine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111707" ], "products": [ "species_1614532", "species_200736" ], "modifiers": [ [ "species_10598474", "catalyst" ] ], "additional_components": [ "Q55DV9", "DDB_G0269122" ] }, "reaction_10598488": { "compartment": "compartment_70101", "id": "reaction_10598488", "reactome": "R-DDI-1614631", "name": "Homocysteine is degraded to oxobutanoate and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_174369" ], "products": [ "species_1614532", "species_29382", "species_936714" ], "modifiers": [ [ "species_10598474", "catalyst" ] ], "additional_components": [ "Q55DV9", "DDB_G0269122" ] }, "reaction_10598464": { "compartment": "compartment_5460", "id": "reaction_10598464", "reactome": "R-DDI-1614544", "name": "Sulfite is oxidized to sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_1614538", "species_113521" ], "products": [ "species_1614617", "species_1614584" ], "modifiers": [ [ "species_10598461", "catalyst" ] ], "additional_components": [ "Q54XJ8", "DDB_G0278893", "species_947539" ] }, "reaction_10598466": { "compartment": "compartment_70616", "id": "reaction_10598466", "reactome": "R-DDI-1614546", "name": "Sulfate is exported to the cytosol in exchange for dicarboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198498", "species_1614584" ], "products": [ "species_113544", "species_174375" ], "modifiers": [ [ "species_10589601", "catalyst" ] ], "additional_components": [ "DDB_G0284225" ] }, "reaction_10599916": { "compartment": "compartment_70101", "id": "reaction_10599916", "reactome": "R-DDI-2028626", "name": "Phosphorylated MOB1A proteins associate with LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599890", "species_10599858" ], "products": [ "species_10599892" ], "modifiers": [], "additional_components": [ "Q54BM4", "DDB_G0293706", "Q54CR8", "DDB_G0292758", "Q54XJ0", "DDB_G0278907", "Q54QV0", "DDB_G0283625", "Q1ZXI5", "DDB_G0278845", "Q54HD2", "DDB_G0289543", "Q54P47", "DDB_G0284839", "Q1ZXI5", "DDB_G0278845", "Q54HD2", "DDB_G0289543", "Q54P47", "DDB_G0284839", "Q54BM4", "DDB_G0293706", "Q54CR8", "DDB_G0292758", "Q54XJ0", "DDB_G0278907", "Q54QV0", "DDB_G0283625" ] }, "reaction_10624545": { "compartment": "compartment_5460", "id": "reaction_10624545", "reactome": "R-DDI-9011595", "name": "GSTZ1 dimer dehalogenates DCA to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9010792", "species_113521" ], "products": [ "species_904849", "species_3301973" ], "modifiers": [ [ "species_10624542", "catalyst" ], [ "species_1655887", "catalyst" ], [ "species_9010792", "inhibitor" ] ], "additional_components": [ "species_29450", "Q54YN2", "DDB_G0278155" ] }, "reaction_10583891": { "compartment": "compartment_12045", "id": "reaction_10583891", "reactome": "R-DDI-162721", "name": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449299" ], "products": [ "species_29420", "species_162681" ], "modifiers": [ [ "species_10583888", "catalyst" ] ], "additional_components": [ "Q54LP3", "DDB_G0286519", "Q556K9", "DDB_G0272588", "Q76NT6", "DDB_G0277435" ] }, "reaction_10611745": { "compartment": "compartment_13959", "id": "reaction_10611745", "reactome": "R-DDI-5694439", "name": "COPII coat binds TRAPPCII and RAB1:GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10588070", "species_10611620", "species_10611571" ], "products": [ "species_10611622" ], "modifiers": [], "additional_components": [ "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q559Q3", "DDB_G0272298", "Q54J84", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54VR1", "DDB_G0288221", "Q8T2J5", "DDB_G0271968", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q55CT5", "DDB_G0270992", "Q54DS8", "DDB_G0292052", "Q54EA5", "DDB_G0291694", "Q55CR0", "DDB_G0269942", "Q54UU1", "DDB_G0280827", "Q54TK7", "DDB_G0281693", "Q54RV6", "DDB_G0282887", "Q54CU7", "DDB_G0292690", "Q54YG5", "DDB_G0278643", "Q557G3", "DDB_G0273467", "Q555X3", "DDB_G0274803", "Q556Z3", "DDB_G0273209", "Q86K94", "DDB_G0277135", "P34139", "DDB_G0283757", "species_29420", "P34139", "DDB_G0283757", "species_29420", "Q54UU1", "DDB_G0280827", "Q54TK7", "DDB_G0281693", "Q54RV6", "DDB_G0282887", "Q54CU7", "DDB_G0292690", "Q54YG5", "DDB_G0278643", "Q557G3", "DDB_G0273467", "Q555X3", "DDB_G0274803", "Q556Z3", "DDB_G0273209", "Q86K94", "DDB_G0277135", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q559Q3", "DDB_G0272298", "Q54J84", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54VR1", "DDB_G0288221", "Q8T2J5", "DDB_G0271968", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q55CT5", "DDB_G0270992", "Q54DS8", "DDB_G0292052", "Q54EA5", "DDB_G0291694", "Q55CR0", "DDB_G0269942" ] }, "reaction_10588096": { "compartment": "compartment_12045", "id": "reaction_10588096", "reactome": "R-DDI-204008", "name": "SEC31:SEC13 and v-SNARE recruitment", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587867", "species_10587880", "species_10588000" ], "products": [ "species_10588002" ], "modifiers": [], "additional_components": [ "Q54DS8", "DDB_G0292052", "Q55CT5", "DDB_G0270992", "Q54EA5", "DDB_G0291694", "Q55CR0", "DDB_G0269942", "Q55BR0", "DDB_G0269198", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54J84", "DDB_G0288221", "Q559Q3", "DDB_G0272298", "Q559R0", "DDB_G0272296", "species_29438", "Q55BR0", "DDB_G0269198", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54J84", "DDB_G0288221", "Q559Q3", "DDB_G0272298", "Q559R0", "DDB_G0272296", "species_29438", "Q55CR0", "DDB_G0269942", "Q54DS8", "DDB_G0292052", "Q55CT5", "DDB_G0270992", "Q54EA5", "DDB_G0291694" ] }, "reaction_10588082": { "compartment": "compartment_70101", "id": "reaction_10588082", "reactome": "R-DDI-203977", "name": "SAR1 Activation And Membrane Binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10588074" ], "products": [ "species_10587919", "species_29420" ], "modifiers": [ [ "species_10588079", "catalyst" ] ], "additional_components": [ "Q559R0", "DDB_G0272296", "species_29420", "Q559R0", "DDB_G0272296", "species_29438", "DDB_G0286167" ] }, "reaction_10611842": { "compartment": "compartment_70101", "id": "reaction_10611842", "reactome": "R-DDI-5694527", "name": "Loss of SAR1B GTPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587994" ], "products": [ "species_29372", "species_10588090", "species_10588074", "species_10587992" ], "modifiers": [ [ "species_10587994", "catalyst" ] ], "additional_components": [ "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54J84", "DDB_G0288221", "Q559Q3", "DDB_G0272298", "Q559R0", "DDB_G0272296", "species_29438", "Q54T59", "DDB_G0281985", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q559R0", "DDB_G0272296", "species_29420", "Q54T59", "DDB_G0281985", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q54Z72", "DDB_G0277797", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54J84", "DDB_G0288221", "Q559Q3", "DDB_G0272298", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54J84", "DDB_G0288221", "Q559Q3", "DDB_G0272298", "Q559R0", "DDB_G0272296", "species_29438" ] }, "reaction_10618326": { "compartment": "compartment_6791047", "id": "reaction_10618326", "reactome": "R-DDI-6814831", "name": "TBC1D20 binds RAB1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611792", "species_10618322" ], "products": [ "species_10618324" ], "modifiers": [], "additional_components": [ "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "DDB_G0283055", "Q54RT5", "DDB_G0283055", "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736" ] }, "reaction_10611687": { "compartment": "compartment_70101", "id": "reaction_10611687", "reactome": "R-DDI-5694421", "name": "PP6 dephosphorylates SEC24", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10611666" ], "products": [ "species_29372", "species_10588088" ], "modifiers": [ [ "species_10611684", "catalyst" ] ], "additional_components": [ "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q55FM2", "DDB_G0268044", "Q54J43", "DDB_G0288307", "Q9U9A3", "DDB_G0272118" ] }, "reaction_10611800": { "compartment": "compartment_6791047", "id": "reaction_10611800", "reactome": "R-DDI-5694441", "name": "CSNK1D phosphorylates SEC23", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10611760" ], "products": [ "species_29370", "species_10587867", "species_10611766", "species_10611620", "species_10611764", "species_10611666", "species_10611792" ], "modifiers": [ [ "species_10611797", "catalyst" ] ], "additional_components": [ "Q54C46", "DDB_G0293248", "Q54UU1", "DDB_G0280827", "Q54TK7", "DDB_G0281693", "Q54RV6", "DDB_G0282887", "Q54CU7", "DDB_G0292690", "Q54YG5", "DDB_G0278643", "Q557G3", "DDB_G0273467", "Q555X3", "DDB_G0274803", "Q556Z3", "DDB_G0273209", "Q86K94", "DDB_G0277135", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q559Q3", "DDB_G0272298", "Q54J84", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54VR1", "DDB_G0288221", "Q8T2J5", "DDB_G0271968", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q55CT5", "DDB_G0270992", "Q54DS8", "DDB_G0292052", "Q54EA5", "DDB_G0291694", "Q55CR0", "DDB_G0269942", "P34139", "DDB_G0283757", "species_29438", "Q553R1", "DDB_G0275331", "Q54DS8", "DDB_G0292052", "Q55CT5", "DDB_G0270992", "Q54EA5", "DDB_G0291694", "Q559Q3", "DDB_G0272298", "Q54J84", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54VR1", "DDB_G0288221", "Q8T2J5", "DDB_G0271968", "Q54T59", "DDB_G0281985", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q54Z72", "DDB_G0277797", "Q54C46", "DDB_G0293248", "Q553R1", "DDB_G0275331", "Q55CR0", "DDB_G0269942", "Q54UU1", "DDB_G0280827", "Q54TK7", "DDB_G0281693", "Q54RV6", "DDB_G0282887", "Q54CU7", "DDB_G0292690", "Q54YG5", "DDB_G0278643", "Q557G3", "DDB_G0273467", "Q555X3", "DDB_G0274803", "Q556Z3", "DDB_G0273209", "Q86K94", "DDB_G0277135", "DDB_G0281985", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "DDB_G0273059" ] }, "reaction_10611738": { "compartment": "compartment_6791047", "id": "reaction_10611738", "reactome": "R-DDI-5694423", "name": "NSF and SNAPs bind cis-SNARE complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611694", "species_10611734", "species_10611703" ], "products": [ "species_10611736" ], "modifiers": [], "additional_components": [ "Q75JI3", "DDB_G0276153", "Q55CR0", "DDB_G0269942", "Q54IJ1", "DDB_G0288719", "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q55FD0", "DDB_G0268452", "Q54NP6", "DDB_G0285111", "Q54NP6", "DDB_G0285111", "Q55CR0", "DDB_G0269942", "Q54IJ1", "DDB_G0288719", "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q55FD0", "DDB_G0268452", "Q75JI3", "DDB_G0276153" ] }, "reaction_10618329": { "compartment": "compartment_6791047", "id": "reaction_10618329", "reactome": "R-DDI-6814833", "name": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618324" ], "products": [ "species_10611571", "species_10618322" ], "modifiers": [ [ "species_10618324", "catalyst" ] ], "additional_components": [ "Q54RT5", "DDB_G0283055", "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "P34139", "DDB_G0283757", "species_29420", "DDB_G0283055", "Q54RT5", "DDB_G0283055", "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736" ] }, "reaction_10611629": { "compartment": "compartment_13959", "id": "reaction_10611629", "reactome": "R-DDI-5694409", "name": "Nucleotide exchange on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10611622" ], "products": [ "species_29420", "species_10611626" ], "modifiers": [ [ "species_10611622", "catalyst" ] ], "additional_components": [ "P34139", "DDB_G0283757", "species_29420", "Q54UU1", "DDB_G0280827", "Q54TK7", "DDB_G0281693", "Q54RV6", "DDB_G0282887", "Q54CU7", "DDB_G0292690", "Q54YG5", "DDB_G0278643", "Q557G3", "DDB_G0273467", "Q555X3", "DDB_G0274803", "Q556Z3", "DDB_G0273209", "Q86K94", "DDB_G0277135", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q559Q3", "DDB_G0272298", "Q54J84", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54VR1", "DDB_G0288221", "Q8T2J5", "DDB_G0271968", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q55CT5", "DDB_G0270992", "Q54DS8", "DDB_G0292052", "Q54EA5", "DDB_G0291694", "Q55CR0", "DDB_G0269942", "Q54UU1", "DDB_G0280827", "Q54TK7", "DDB_G0281693", "Q54RV6", "DDB_G0282887", "Q54CU7", "DDB_G0292690", "Q54YG5", "DDB_G0278643", "Q557G3", "DDB_G0273467", "Q555X3", "DDB_G0274803", "Q556Z3", "DDB_G0273209", "Q86K94", "DDB_G0277135", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q559Q3", "DDB_G0272298", "Q54J84", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54VR1", "DDB_G0288221", "Q8T2J5", "DDB_G0271968", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q55CT5", "DDB_G0270992", "Q54DS8", "DDB_G0292052", "Q54EA5", "DDB_G0291694", "Q55CR0", "DDB_G0269942", "P34139", "DDB_G0283757", "species_29438", "P34139", "DDB_G0283757", "species_29420", "Q54UU1", "DDB_G0280827", "Q54TK7", "DDB_G0281693", "Q54RV6", "DDB_G0282887", "Q54CU7", "DDB_G0292690", "Q54YG5", "DDB_G0278643", "Q557G3", "DDB_G0273467", "Q555X3", "DDB_G0274803", "Q556Z3", "DDB_G0273209", "Q86K94", "DDB_G0277135", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q559Q3", "DDB_G0272298", "Q54J84", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54VR1", "DDB_G0288221", "Q8T2J5", "DDB_G0271968", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q55CT5", "DDB_G0270992", "Q54DS8", "DDB_G0292052", "Q54EA5", "DDB_G0291694", "Q55CR0", "DDB_G0269942" ] }, "reaction_10611741": { "compartment": "compartment_6791047", "id": "reaction_10611741", "reactome": "R-DDI-5694425", "name": "NSF ATPase activity dissociates cis-SNARE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10611736" ], "products": [ "species_10611694", "species_10611710", "species_10611724", "species_10611708", "species_29372", "species_10611703", "species_10611732", "species_10611715" ], "modifiers": [ [ "species_10611736", "catalyst" ] ], "additional_components": [ "Q54NP6", "DDB_G0285111", "Q55CR0", "DDB_G0269942", "Q54IJ1", "DDB_G0288719", "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q55FD0", "DDB_G0268452", "Q75JI3", "DDB_G0276153", "Q75JI3", "DDB_G0276153", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "DDB_G0282433", "Q54NP6", "DDB_G0285111", "Q55CR0", "DDB_G0269942", "DDB_G0288719", "Q54NP6", "DDB_G0285111", "Q55CR0", "DDB_G0269942", "Q54IJ1", "DDB_G0288719", "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q55FD0", "DDB_G0268452", "Q75JI3", "DDB_G0276153" ] }, "reaction_10611839": { "compartment": "compartment_12045", "id": "reaction_10611839", "reactome": "R-DDI-5694522", "name": "Inner coat assembly and cargo binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587919", "species_10588090", "species_10587992" ], "products": [ "species_10587994" ], "modifiers": [], "additional_components": [ "Q559R0", "DDB_G0272296", "species_29438", "Q54T59", "DDB_G0281985", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q54Z72", "DDB_G0277797", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54J84", "DDB_G0288221", "Q559Q3", "DDB_G0272298", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54J84", "DDB_G0288221", "Q559Q3", "DDB_G0272298", "Q559R0", "DDB_G0272296", "species_29438" ] }, "reaction_10617088": { "compartment": "compartment_432051", "id": "reaction_10617088", "reactome": "R-DDI-6809003", "name": "ERGIC-to-Golgi vesicles bind dynein:dynactin ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617084", "species_10605683" ], "products": [ "species_10617086" ], "modifiers": [], "additional_components": [ "Q54BK5", "DDB_G0293712", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "Q558I0", "DDB_G0272905", "P34141", "DDB_G0291233", "P34140", "DDB_G0277867", "Q54EW9", "DDB_G0291293", "P34143", "DDB_G0271736", "Q552K3", "DDB_G0275969", "Q54NU2", "DDB_G0284985", "species_29438", "Q553R1", "DDB_G0275331", "Q54HL0", "DDB_G0289371", "Q23924", "DDB_G0284735", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "Q54HD4", "DDB_G0289523", "Q55FR9", "DDB_G0267982", "Q55FU2", "DDB_G0267950", "Q54YD8", "DDB_G0278285", "Q769F6", "DDB_G0277923", "Q769F9", "DDB_G0288053", "Q54BN0", "DDB_G0293540", "Q769F7", "DDB_G0278969", "Q86JE5", "DDB_G0272124", "Q54SJ2", "DDB_G0282433", "Q54V78", "DDB_G0280565", "P05095", "DDB_G0268632", "Q550R2", "DDB_G0276893", "P54703", "DDB_G0280849", "Q86A88", "DDB_G0274815", "Q54CI8", "DDB_G0292904", "P34036", "DDB_G0276355", "Q54VD6", "DDB_G0280435", "Q54ZI7", "DDB_G0277561", "Q54N50", "DDB_G0285503", "P13021", "DDB_G0267374", "P13022", "DDB_G0272104", "Q54JY2", "DDB_G0287739", "Q54FM4", "DDB_G0290757", "Q54VS0", "DDB_G0280175", "Q54XU5", "DDB_G0278579", "Q54I79", "DDB_G0288937", "species_29438", "species_29420", "P54703", "DDB_G0280849", "Q86A88", "DDB_G0274815", "Q54CI8", "DDB_G0292904", "P34036", "DDB_G0276355", "Q54VD6", "DDB_G0280435", "Q54ZI7", "DDB_G0277561", "Q54N50", "DDB_G0285503", "P13021", "DDB_G0267374", "P13022", "DDB_G0272104", "Q54JY2", "DDB_G0287739", "Q54FM4", "DDB_G0290757", "Q54VS0", "DDB_G0280175", "Q54XU5", "DDB_G0278579", "Q54I79", "DDB_G0288937", "species_29438", "species_29420", "Q54BK5", "DDB_G0293712", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "Q558I0", "DDB_G0272905", "P34141", "DDB_G0291233", "P34140", "DDB_G0277867", "Q54EW9", "DDB_G0291293", "P34143", "DDB_G0271736", "Q552K3", "DDB_G0275969", "Q54NU2", "DDB_G0284985", "Q553R1", "DDB_G0275331", "Q54HL0", "DDB_G0289371", "Q23924", "DDB_G0284735", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "Q54HD4", "DDB_G0289523", "Q55FR9", "DDB_G0267982", "Q55FU2", "DDB_G0267950", "Q54YD8", "DDB_G0278285", "Q769F6", "DDB_G0277923", "Q769F9", "DDB_G0288053", "Q54BN0", "DDB_G0293540", "Q769F7", "DDB_G0278969", "Q86JE5", "DDB_G0272124", "Q54SJ2", "DDB_G0282433", "Q54V78", "DDB_G0280565", "P05095", "DDB_G0268632", "Q550R2", "DDB_G0276893" ] }, "reaction_10617281": { "compartment": "compartment_20699", "id": "reaction_10617281", "reactome": "R-DDI-6809015", "name": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617276", "species_113592" ], "products": [ "species_29372", "species_10617262", "species_10617256", "species_10617258", "species_10617237", "species_10617143", "species_10617254" ], "modifiers": [ [ "species_10617276", "catalyst" ] ], "additional_components": [ "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712", "Q54QH2", "DDB_G0283831", "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q55FD0", "DDB_G0268452", "Q75JI3", "DDB_G0276153", "DDB_G0268452", "DDB_G0282433", "DDB_G0277565", "DDB_G0282433", "DDB_G0293712", "DDB_G0283831", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712", "Q54QH2", "DDB_G0283831", "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q55FD0", "DDB_G0268452", "Q75JI3", "DDB_G0276153" ] }, "reaction_10616792": { "compartment": "compartment_6791047", "id": "reaction_10616792", "reactome": "R-DDI-6807868", "name": "GBF1 stimulates ARF nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10616785" ], "products": [ "species_29370", "species_10616789" ], "modifiers": [ [ "species_10616785", "catalyst" ] ], "additional_components": [ "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q553R1", "DDB_G0275331", "species_29420", "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q553R1", "DDB_G0275331", "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q553R1", "DDB_G0275331", "species_29420" ] }, "reaction_10616779": { "compartment": "compartment_6791047", "id": "reaction_10616779", "reactome": "R-DDI-6807864", "name": "RAB1:GTP recruits GBF1 to the ERGIC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616775", "species_10616771", "species_10611792" ], "products": [ "species_10616777" ], "modifiers": [], "additional_components": [ "Q553R1", "DDB_G0275331", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q553R1", "DDB_G0275331" ] }, "reaction_10617272": { "compartment": "compartment_20699", "id": "reaction_10617272", "reactome": "R-DDI-6809011", "name": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617268", "species_10617249" ], "products": [ "species_10617270" ], "modifiers": [], "additional_components": [ "Q54QH2", "DDB_G0283831", "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q55FD0", "DDB_G0268452", "Q54C46", "DDB_G0293248", "Q54YV5", "DDB_G0278061", "Q54LC8", "DDB_G0286705", "Q54C87", "DDB_G0293106", "Q54ZB3", "DDB_G0277691", "Q54UC2", "DDB_G0281163", "Q55BB8", "DDB_G0271388", "Q54HE0", "DDB_G0289535", "Q54CT0", "DDB_G0292784", "Q54TT4", "DDB_G0281511", "Q769F9", "DDB_G0288053", "Q54BN0", "DDB_G0293540", "Q769F6", "DDB_G0277923", "Q769F7", "DDB_G0278969", "Q54BK5", "DDB_G0293712", "Q55FU2", "DDB_G0267950", "Q54YD8", "DDB_G0278285", "Q55FR9", "DDB_G0267982", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "Q54HD4", "DDB_G0289523", "Q54HL0", "DDB_G0289371", "Q23924", "DDB_G0284735", "Q553R1", "DDB_G0275331", "species_29438", "Q552K3", "DDB_G0275969", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "Q558I0", "DDB_G0272905", "P34141", "DDB_G0291233", "P34140", "DDB_G0277867", "Q54EW9", "DDB_G0291293", "P34143", "DDB_G0271736", "Q86JE5", "DDB_G0272124", "Q54SJ2", "DDB_G0282433", "Q54V78", "DDB_G0280565", "P05095", "DDB_G0268632", "Q550R2", "DDB_G0276893", "Q54C46", "DDB_G0293248", "Q54YV5", "DDB_G0278061", "Q54LC8", "DDB_G0286705", "Q54C87", "DDB_G0293106", "Q54ZB3", "DDB_G0277691", "Q54UC2", "DDB_G0281163", "Q55BB8", "DDB_G0271388", "Q54HE0", "DDB_G0289535", "Q54CT0", "DDB_G0292784", "Q54TT4", "DDB_G0281511", "Q769F9", "DDB_G0288053", "Q54BN0", "DDB_G0293540", "Q769F6", "DDB_G0277923", "Q769F7", "DDB_G0278969", "Q54BK5", "DDB_G0293712", "Q55FU2", "DDB_G0267950", "Q54YD8", "DDB_G0278285", "Q55FR9", "DDB_G0267982", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "Q54HD4", "DDB_G0289523", "Q54HL0", "DDB_G0289371", "Q23924", "DDB_G0284735", "Q553R1", "DDB_G0275331", "species_29438", "Q552K3", "DDB_G0275969", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "Q558I0", "DDB_G0272905", "P34141", "DDB_G0291233", "P34140", "DDB_G0277867", "Q54EW9", "DDB_G0291293", "P34143", "DDB_G0271736", "Q86JE5", "DDB_G0272124", "Q54SJ2", "DDB_G0282433", "Q54V78", "DDB_G0280565", "P05095", "DDB_G0268632", "Q550R2", "DDB_G0276893", "Q54QH2", "DDB_G0283831", "Q54ZH1", "DDB_G0277565", "Q55FD0", "DDB_G0268452" ] }, "reaction_10617278": { "compartment": "compartment_20699", "id": "reaction_10617278", "reactome": "R-DDI-6809014", "name": "cis-Golgi cis-SNARE binds NSF and SNAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611694", "species_10617274", "species_10611703" ], "products": [ "species_10617276" ], "modifiers": [], "additional_components": [ "Q75JI3", "DDB_G0276153", "Q54BK5", "DDB_G0293712", "Q54QH2", "DDB_G0283831", "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q55FD0", "DDB_G0268452", "Q54NP6", "DDB_G0285111", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712", "Q54QH2", "DDB_G0283831", "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q55FD0", "DDB_G0268452", "Q75JI3", "DDB_G0276153" ] }, "reaction_10616847": { "compartment": "compartment_6791047", "id": "reaction_10616847", "reactome": "R-DDI-6807872", "name": "Active ARF recruits coatomer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616843", "species_10616789" ], "products": [ "species_10616845" ], "modifiers": [], "additional_components": [ "Q55EZ6", "DDB_G0268702", "Q23924", "DDB_G0284735", "Q54HL0", "DDB_G0289371", "Q54CA7", "DDB_G0293086", "Q54HD4", "DDB_G0289523", "Q54YD8", "DDB_G0278285", "Q55FU2", "DDB_G0267950", "Q55FR9", "DDB_G0267982", "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q553R1", "DDB_G0275331", "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q553R1", "DDB_G0275331", "Q55EZ6", "DDB_G0268702", "Q23924", "DDB_G0284735", "Q54HL0", "DDB_G0289371", "Q54CA7", "DDB_G0293086", "Q54HD4", "DDB_G0289523", "Q54YD8", "DDB_G0278285", "Q55FU2", "DDB_G0267950", "Q55FR9", "DDB_G0267982" ] }, "reaction_10611650": { "compartment": "compartment_12045", "id": "reaction_10611650", "reactome": "R-DDI-5694413", "name": "SEC4C,D bind GOSR2 and STX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587933", "species_10587931", "species_10587937" ], "products": [ "species_10587939" ], "modifiers": [], "additional_components": [ "DDB_G0277797", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "DDB_G0281985", "Q54T59", "DDB_G0281985", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q54Z72", "DDB_G0277797" ] }, "reaction_10611654": { "compartment": "compartment_12045", "id": "reaction_10611654", "reactome": "R-DDI-5694415", "name": "SEC24A,B:SEC23A bind SEC22B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10588084", "species_10587872", "species_10587937" ], "products": [ "species_10611652" ], "modifiers": [], "additional_components": [ "DDB_G0281255", "DDB_G0269942", "DDB_G0281985", "Q55CR0", "DDB_G0269942", "Q54U61", "DDB_G0281255", "Q54T59", "DDB_G0281985" ] }, "reaction_10611743": { "compartment": "compartment_12045", "id": "reaction_10611743", "reactome": "R-DDI-5694428", "name": "LMAN family proteins bind glycosylated cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587988", "species_10587954" ], "products": [ "species_10587990" ], "modifiers": [], "additional_components": [ "Q54VR1", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54J84", "DDB_G0288221", "Q559Q3", "DDB_G0272298", "Q8T2J5", "DDB_G0271968", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54J84", "DDB_G0288221", "Q559Q3", "DDB_G0272298" ] }, "reaction_10626054": { "compartment": "compartment_876", "id": "reaction_10626054", "reactome": "R-DDI-9606884", "name": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_113592", "species_10626042" ], "products": [ "species_29370", "species_10626052" ], "modifiers": [], "additional_components": [ "Q54CE1", "DDB_G0293166", "Q54U56", "DDB_G0293166", "Q54U56", "DDB_G0293166", "Q54CE1", "DDB_G0293166", "species_179838" ] }, "reaction_10597136": { "compartment": "compartment_876", "id": "reaction_10597136", "reactome": "R-DDI-1168636", "name": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10585874" ], "products": [ "species_29420", "species_10585144" ], "modifiers": [ [ "species_10597133", "catalyst" ] ], "additional_components": [ "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29420", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "species_6797635", "Q8IS15", "DDB_G0277915", "Q8IS16", "DDB_G0276963", "B0M0P8", "DDB_G0276371", "Q54C94", "DDB_G0293006", "Q8IS20", "DDB_G0282381", "Q8IS21", "DDB_G0269222", "Q54FF3", "DDB_G0290901", "Q54H95", "DDB_G0289613", "Q8SSQ0", "DDB_G0274605", "Q8SSW7", "DDB_G0271868", "Q54PQ4", "DDB_G0284329", "Q54XL4", "DDB_G0289613", "Q8ST25", "DDB_G0272032", "Q55FD8", "DDB_G0268578", "Q55GH9", "DDB_G0267666", "Q8IS11", "DDB_G0290267", "Q8IS14", "DDB_G0277913" ] }, "reaction_10627377": { "compartment": "compartment_70101", "id": "reaction_10627377", "reactome": "R-DDI-9690461", "name": "FKBP1A binds tacrolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584268", "species_9678991" ], "products": [ "species_10627375" ], "modifiers": [], "additional_components": [ "DDB_G0280877", "Q54UR2", "DDB_G0280877" ] }, "reaction_10622977": { "compartment": "compartment_7660", "id": "reaction_10622977", "reactome": "R-DDI-8937022", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10622972" ], "products": [ "species_77502", "species_10622974" ], "modifiers": [ [ "species_10622972", "catalyst" ] ], "additional_components": [ "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863", "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "O15819", "DDB_G0267402", "Q54F38", "DDB_G0291185", "Q76NW2", "DDB_G0276863", "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863" ] }, "reaction_10622950": { "compartment": "compartment_7660", "id": "reaction_10622950", "reactome": "R-DDI-8936608", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10622945" ], "products": [ "species_77502", "species_10622947" ], "modifiers": [ [ "species_10622945", "catalyst" ] ], "additional_components": [ "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863", "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "O15819", "DDB_G0267402", "Q54F38", "DDB_G0291185", "Q76NW2", "DDB_G0276863", "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863" ] }, "reaction_10622986": { "compartment": "compartment_7660", "id": "reaction_10622986", "reactome": "R-DDI-8937113", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10622981" ], "products": [ "species_77502", "species_10622983" ], "modifiers": [ [ "species_10622981", "catalyst" ] ], "additional_components": [ "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863", "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "O15819", "DDB_G0267402", "Q54F38", "DDB_G0291185", "Q76NW2", "DDB_G0276863", "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863" ] }, "reaction_10622941": { "compartment": "compartment_7660", "id": "reaction_10622941", "reactome": "R-DDI-8936584", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10622927" ], "products": [ "species_77502", "species_10622938" ], "modifiers": [ [ "species_10622927", "catalyst" ] ], "additional_components": [ "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863", "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "O15819", "DDB_G0267402", "Q54F38", "DDB_G0291185", "Q76NW2", "DDB_G0276863", "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863" ] }, "reaction_10583367": { "compartment": "compartment_17906", "id": "reaction_10583367", "reactome": "R-DDI-114284", "name": "Release of Cytochrome c from mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583365" ], "products": [ "species_10583363" ], "modifiers": [], "additional_components": [ "DDB_G0275537", "DDB_G0275537" ] }, "reaction_10582546": { "compartment": "compartment_7660", "id": "reaction_10582546", "reactome": "R-DDI-109636", "name": "Recognition and Binding of Core Promoter Elements by TFIID", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580910", "species_109627" ], "products": [ "species_10581548" ], "modifiers": [], "additional_components": [ "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617" ] }, "reaction_10582548": { "compartment": "compartment_7660", "id": "reaction_10582548", "reactome": "R-DDI-109637", "name": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580844", "species_10581548", "species_10580839" ], "products": [ "species_10581550" ], "modifiers": [], "additional_components": [ "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54FD6", "DDB_G0290929" ] }, "reaction_10581556": { "compartment": "compartment_7660", "id": "reaction_10581556", "reactome": "R-DDI-75095", "name": "Binding of TFIIE to the growing preinitiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580922", "species_10581552" ], "products": [ "species_10581554" ], "modifiers": [], "additional_components": [ "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54FD6", "DDB_G0290929", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54FD6", "DDB_G0290929", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307" ] }, "reaction_10582550": { "compartment": "compartment_7660", "id": "reaction_10582550", "reactome": "R-DDI-109638", "name": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581550", "species_10578889" ], "products": [ "species_10581552" ], "modifiers": [], "additional_components": [ "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54FD6", "DDB_G0290929", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54FD6", "DDB_G0290929" ] }, "reaction_10582552": { "compartment": "compartment_7660", "id": "reaction_10582552", "reactome": "R-DDI-109639", "name": "Formation of the closed pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580699", "species_10581554" ], "products": [ "species_10581638" ], "modifiers": [], "additional_components": [ "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54FD6", "DDB_G0290929", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54FD6", "DDB_G0290929", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307" ] }, "reaction_10582721": { "compartment": "compartment_7660", "id": "reaction_10582721", "reactome": "R-DDI-110227", "name": "Cleavage of dihydrouracil by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582718" ], "products": [ "species_30140", "species_10582704" ], "modifiers": [ [ "species_10582718", "catalyst" ] ], "additional_components": [ "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247" ] }, "reaction_10582691": { "compartment": "compartment_7660", "id": "reaction_10582691", "reactome": "R-DDI-110215", "name": "Cleavage of uracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582684" ], "products": [ "species_29554", "species_10582688" ], "modifiers": [ [ "species_10582684", "catalyst" ] ], "additional_components": [ "P53766", "DDB_G0277877", "P53766", "DDB_G0277877", "P53766", "DDB_G0277877" ] }, "reaction_10582707": { "compartment": "compartment_7660", "id": "reaction_10582707", "reactome": "R-DDI-110224", "name": "Cleavage of thymine glycol by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582702" ], "products": [ "species_110223", "species_10582704" ], "modifiers": [ [ "species_10582702", "catalyst" ] ], "additional_components": [ "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247" ] }, "reaction_10582728": { "compartment": "compartment_7660", "id": "reaction_10582728", "reactome": "R-DDI-110229", "name": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582725" ], "products": [ "species_5637659", "species_10582704" ], "modifiers": [ [ "species_10582725", "catalyst" ] ], "additional_components": [ "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247" ] }, "reaction_10582747": { "compartment": "compartment_7660", "id": "reaction_10582747", "reactome": "R-DDI-110244", "name": "Excision of FapyG by OGG1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582744" ], "products": [ "species_5636006", "species_10582739" ], "modifiers": [ [ "species_10582744", "catalyst" ] ], "additional_components": [ "Q54CZ3", "DDB_G0292618", "Q54CZ3", "DDB_G0292618", "Q54CZ3", "DDB_G0292618" ] }, "reaction_10582698": { "compartment": "compartment_7660", "id": "reaction_10582698", "reactome": "R-DDI-110217", "name": "Cleavage of 5-hydroxyluracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582695" ], "products": [ "species_110216", "species_10582688" ], "modifiers": [ [ "species_10582695", "catalyst" ] ], "additional_components": [ "P53766", "DDB_G0277877", "P53766", "DDB_G0277877", "P53766", "DDB_G0277877" ] }, "reaction_10582714": { "compartment": "compartment_7660", "id": "reaction_10582714", "reactome": "R-DDI-110226", "name": "Cleavage of cytosine glycol by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582711" ], "products": [ "species_10582704", "species_110225" ], "modifiers": [ [ "species_10582711", "catalyst" ] ], "additional_components": [ "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247" ] }, "reaction_10604323": { "compartment": "compartment_17963", "id": "reaction_10604323", "reactome": "R-DDI-4837364", "name": "Secretion of SOD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604321" ], "products": [ "species_10602381" ], "modifiers": [], "additional_components": [ "species_29426", "species_437295", "Q55GQ5", "DDB_G0267420", "species_29426", "Q55GQ5", "DDB_G0267420", "species_437295" ] }, "reaction_10602402": { "compartment": "compartment_70101", "id": "reaction_10602402", "reactome": "R-DDI-3299691", "name": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_1222424" ], "products": [ "species_29368", "species_29408" ], "modifiers": [ [ "species_10602399", "catalyst" ] ], "additional_components": [ "species_29426", "species_437295", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993", "Q55GQ5", "DDB_G0267420" ] }, "reaction_10602373": { "compartment": "compartment_5460", "id": "reaction_10602373", "reactome": "R-DDI-3299680", "name": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_3299683" ], "products": [ "species_113533", "species_1614617" ], "modifiers": [ [ "species_10602370", "catalyst" ] ], "additional_components": [ "species_266099", "Q55BJ9", "DDB_G0271106" ] }, "reaction_10602664": { "compartment": "compartment_5460", "id": "reaction_10602664", "reactome": "R-DDI-3323079", "name": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_1655882", "species_113600" ], "products": [ "species_113563", "species_1655887" ], "modifiers": [ [ "species_10602661", "catalyst" ] ], "additional_components": [ "Q8T137", "DDB_G0272754", "species_113596" ] }, "reaction_10602668": { "compartment": "compartment_70616", "id": "reaction_10602668", "reactome": "R-DDI-3341294", "name": "Superoxide reduces cytochrome c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3341308", "species_10584033" ], "products": [ "species_10584031", "species_189461" ], "modifiers": [], "additional_components": [ "CHEBI:38574", "Q869N1", "DDB_G0275537", "CHEBI:38573", "Q869N1", "DDB_G0275537" ] }, "reaction_10602384": { "compartment": "compartment_984", "id": "reaction_10602384", "reactome": "R-DDI-3299682", "name": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_3299686" ], "products": [ "species_351629", "species_352327" ], "modifiers": [ [ "species_10602381", "catalyst" ] ], "additional_components": [ "species_29426", "Q55GQ5", "DDB_G0267420", "species_437295" ] }, "reaction_10602421": { "compartment": "compartment_70101", "id": "reaction_10602421", "reactome": "R-DDI-3299753", "name": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602414" ], "products": [ "species_10602399", "species_10602418" ], "modifiers": [ [ "species_10602414", "catalyst" ] ], "additional_components": [ "CHEBI:49552", "species_29426", "Q54F73", "DDB_G0291031", "Q55GQ5", "DDB_G0267420", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993", "species_29426", "species_437295", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993", "Q55GQ5", "DDB_G0267420", "species_29426", "CHEBI:49552", "Q54F73", "DDB_G0291031", "CHEBI:49552", "species_29426", "Q54F73", "DDB_G0291031", "Q55GQ5", "DDB_G0267420", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993" ] }, "reaction_10603063": { "compartment": "compartment_70101", "id": "reaction_10603063", "reactome": "R-DDI-3697860", "name": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602412", "species_10603059" ], "products": [ "species_10603061" ], "modifiers": [], "additional_components": [ "species_29426", "Q55GQ5", "DDB_G0267420", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993", "CHEBI:49552", "species_29426", "Q54F73", "DDB_G0291031", "CHEBI:49552", "species_29426", "Q54F73", "DDB_G0291031", "Q55GQ5", "DDB_G0267420", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993" ] }, "reaction_10616759": { "compartment": "compartment_12045", "id": "reaction_10616759", "reactome": "R-DDI-6807557", "name": "NOX4, NOX5 reduce O2 to O2.-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29364" ], "products": [ "species_70106", "species_1222424", "species_29366" ], "modifiers": [ [ "species_10616756", "catalyst" ] ], "additional_components": [ "Q867X6", "DDB_G0267460", "Q54F44", "DDB_G0291117", "Q86GL4", "DDB_G0287101", "Q9XYS3", "DDB_G0289653" ] }, "reaction_10623544": { "compartment": "compartment_70101", "id": "reaction_10623544", "reactome": "R-DDI-8951723", "name": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603061" ], "products": [ "species_10602414" ], "modifiers": [], "additional_components": [ "CHEBI:49552", "species_29426", "Q54F73", "DDB_G0291031", "Q55GQ5", "DDB_G0267420", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993", "CHEBI:49552", "species_29426", "Q54F73", "DDB_G0291031", "Q55GQ5", "DDB_G0267420", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993" ] }, "reaction_10603066": { "compartment": "compartment_5460", "id": "reaction_10603066", "reactome": "R-DDI-3697894", "name": "PRDX5 reduces peroxynitrite to nitrite using TXN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602633", "species_3697881" ], "products": [ "species_10602636", "species_3697842", "species_113521" ], "modifiers": [ [ "species_10602650", "catalyst" ] ], "additional_components": [ "DDB_G0284939", "DDB_G0284939", "DDB_G0285741" ] }, "reaction_10603197": { "compartment": "compartment_17927", "id": "reaction_10603197", "reactome": "R-DDI-3777112", "name": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3341308", "species_163953" ], "products": [ "species_189481", "species_189461" ], "modifiers": [ [ "species_10603194", "catalyst" ] ], "additional_components": [ "species_437295", "species_29426", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993", "Q55GQ5", "DDB_G0267420" ] }, "reaction_10581788": { "compartment": "compartment_17951", "id": "reaction_10581788", "reactome": "R-DDI-76031", "name": "2 H2O2 => O2 + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113575" ], "products": [ "species_113535", "species_141343" ], "modifiers": [ [ "species_10581785", "catalyst" ] ], "additional_components": [ "species_917877", "species_29364", "O77229", "DDB_G0274595" ] }, "reaction_10602655": { "compartment": "compartment_5460", "id": "reaction_10602655", "reactome": "R-DDI-3322995", "name": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602633", "species_1614617" ], "products": [ "species_10602636", "species_113521" ], "modifiers": [ [ "species_10602652", "catalyst" ] ], "additional_components": [ "DDB_G0284939", "DDB_G0284939", "Q54W09", "DDB_G0279973", "Q54N76", "DDB_G0285741" ] }, "reaction_10602686": { "compartment": "compartment_70101", "id": "reaction_10602686", "reactome": "R-DDI-3343700", "name": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_29408" ], "products": [ "species_29356", "species_111745" ], "modifiers": [ [ "species_10602683", "catalyst" ] ], "additional_components": [ "Q556P3", "DDB_G0273153", "Q55FF3", "DDB_G0268138", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q54VI4", "DDB_G0280317", "Q556G3", "DDB_G0272632", "Q54SE2", "DDB_G0282517" ] }, "reaction_10600900": { "compartment": "compartment_70101", "id": "reaction_10600900", "reactome": "R-DDI-2393939", "name": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1131972" ], "products": [ "species_73578", "species_76577" ], "modifiers": [ [ "species_10600897", "catalyst" ] ], "additional_components": [ "species_29926", "Q54S89", "DDB_G0282603" ] }, "reaction_10577424": { "compartment": "compartment_7660", "id": "reaction_10577424", "reactome": "R-DDI-69053", "name": "RFC binding displaces Pol Alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577420", "species_10577245" ], "products": [ "species_10577422" ], "modifiers": [], "additional_components": [ "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MD4", "DDB_G0286027", "Q54MH9", "DDB_G0285961", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MD4", "DDB_G0286027", "Q54MH9", "DDB_G0285961" ] }, "reaction_10577462": { "compartment": "compartment_7660", "id": "reaction_10577462", "reactome": "R-DDI-69074", "name": "Formation of Processive Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577437", "species_10577458" ], "products": [ "species_10577460" ], "modifiers": [], "additional_components": [ "Q54K47", "DDB_G0287607", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731" ] }, "reaction_10577435": { "compartment": "compartment_7660", "id": "reaction_10577435", "reactome": "R-DDI-69063", "name": "Loading of PCNA - Sliding Clamp Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577422", "species_29358", "species_10577431" ], "products": [ "species_113582", "species_10577433" ], "modifiers": [], "additional_components": [ "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MD4", "DDB_G0286027", "Q54MH9", "DDB_G0285961", "Q54K47", "DDB_G0287607", "Q54K47", "DDB_G0287607", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MD4", "DDB_G0286027", "Q54MH9", "DDB_G0285961" ] }, "reaction_10577439": { "compartment": "compartment_7660", "id": "reaction_10577439", "reactome": "R-DDI-69068", "name": "RFC dissociates after sliding clamp formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577433" ], "products": [ "species_10577420", "species_10577437" ], "modifiers": [], "additional_components": [ "Q54K47", "DDB_G0287607", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MD4", "DDB_G0286027", "Q54MH9", "DDB_G0285961", "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MD4", "DDB_G0286027", "Q54MH9", "DDB_G0285961", "Q54K47", "DDB_G0287607", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731" ] }, "reaction_10618449": { "compartment": "compartment_20699", "id": "reaction_10618449", "reactome": "R-DDI-8847887", "name": "RAB33B:GTP binds RIC1:RGP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618445", "species_10618439" ], "products": [ "species_10618447" ], "modifiers": [], "additional_components": [ "Q54WR7", "DDB_G0279477", "Q76NU4", "DDB_G0277397", "O76173", "DDB_G0269174", "species_29438", "O76173", "DDB_G0269174", "species_29438", "Q54WR7", "DDB_G0279477", "Q76NU4", "DDB_G0277397" ] }, "reaction_10618433": { "compartment": "compartment_20699", "id": "reaction_10618433", "reactome": "R-DDI-8847883", "name": "CYTH proteins stimulate ARF1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618424" ], "products": [ "species_10618430" ], "modifiers": [ [ "species_10618424", "catalyst" ] ], "additional_components": [ "species_29438", "O00909", "DDB_G0289173", "Q54Y34", "DDB_G0292332", "Q1ZXA5", "DDB_G0292332", "Q54YV7", "DDB_G0278057", "Q54HK2", "DDB_G0289435", "Q55AR1", "DDB_G0271792", "Q54JJ3", "DDB_G0288015", "Q54SH9", "DDB_G0282457", "Q54V41", "DDB_G0280633", "Q54V47", "DDB_G0280621", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "O00909", "DDB_G0289173", "Q54Y34", "DDB_G0292332", "Q1ZXA5", "DDB_G0292332", "Q54YV7", "DDB_G0278057", "Q54HK2", "DDB_G0289435", "Q55AR1", "DDB_G0271792", "Q54JJ3", "DDB_G0288015", "Q54SH9", "DDB_G0282457", "Q54V41", "DDB_G0280633", "Q54V47", "DDB_G0280621", "Q54VB0", "DDB_G0280479", "species_29420", "species_29438", "O00909", "DDB_G0289173", "Q54Y34", "DDB_G0292332", "Q1ZXA5", "DDB_G0292332", "Q54YV7", "DDB_G0278057", "Q54HK2", "DDB_G0289435", "Q55AR1", "DDB_G0271792", "Q54JJ3", "DDB_G0288015", "Q54SH9", "DDB_G0282457", "Q54V41", "DDB_G0280633", "Q54V47", "DDB_G0280621", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771" ] }, "reaction_10618612": { "compartment": "compartment_20699", "id": "reaction_10618612", "reactome": "R-DDI-8849748", "name": "The COG complex binds RABs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617130", "species_10618608" ], "products": [ "species_10618610" ], "modifiers": [], "additional_components": [ "Q54LC8", "DDB_G0286705", "Q54C87", "DDB_G0293106", "Q54ZB3", "DDB_G0277691", "Q54UC2", "DDB_G0281163", "Q55BB8", "DDB_G0271388", "Q54HE0", "DDB_G0289535", "Q54CT0", "DDB_G0292784", "Q54TT4", "DDB_G0281511", "Q54G48", "DDB_G0290407", "Q54FL2", "DDB_G0290783", "Q54S62", "DDB_G0294577", "Q54P07", "DDB_G0285051", "Q55EF0", "DDB_G0269262", "Q54S63", "DDB_G0282651", "Q86JC8", "DDB_G0275955", "Q55EG6", "DDB_G0268910", "Q8T193", "DDB_G0294577", "Q86JP5", "DDB_G0271980", "Q1ZXG2", "DDB_G0294577", "Q54E92", "DDB_G0291738", "Q1ZXN9", "DDB_G0294577", "species_29438", "Q559X6", "DDB_G0272138", "Q55ET3", "DDB_G0268760", "P36409", "DDB_G0292268", "Q55FK2", "DDB_G0268068", "Q54G48", "DDB_G0290407", "Q54FL2", "DDB_G0290783", "Q54S62", "DDB_G0294577", "Q54P07", "DDB_G0285051", "Q55EF0", "DDB_G0269262", "Q54S63", "DDB_G0282651", "Q86JC8", "DDB_G0275955", "Q55EG6", "DDB_G0268910", "Q8T193", "DDB_G0294577", "Q86JP5", "DDB_G0271980", "Q1ZXG2", "DDB_G0294577", "Q54E92", "DDB_G0291738", "Q1ZXN9", "DDB_G0294577", "species_29438", "Q559X6", "DDB_G0272138", "Q55ET3", "DDB_G0268760", "P36409", "DDB_G0292268", "Q55FK2", "DDB_G0268068", "Q54LC8", "DDB_G0286705", "Q54C87", "DDB_G0293106", "Q54ZB3", "DDB_G0277691", "Q54UC2", "DDB_G0281163", "Q55BB8", "DDB_G0271388", "Q54HE0", "DDB_G0289535", "Q54CT0", "DDB_G0292784", "Q54TT4", "DDB_G0281511" ] }, "reaction_10618426": { "compartment": "compartment_20699", "id": "reaction_10618426", "reactome": "R-DDI-8847880", "name": "CYTH proteins bind ARF1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598835", "species_10618402" ], "products": [ "species_10618424" ], "modifiers": [], "additional_components": [ "species_29438", "O00909", "DDB_G0289173", "Q54Y34", "DDB_G0292332", "Q1ZXA5", "DDB_G0292332", "Q54YV7", "DDB_G0278057", "Q54HK2", "DDB_G0289435", "Q55AR1", "DDB_G0271792", "Q54JJ3", "DDB_G0288015", "Q54SH9", "DDB_G0282457", "Q54V41", "DDB_G0280633", "Q54V47", "DDB_G0280621", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "species_29438", "O00909", "DDB_G0289173", "Q54Y34", "DDB_G0292332", "Q1ZXA5", "DDB_G0292332", "Q54YV7", "DDB_G0278057", "Q54HK2", "DDB_G0289435", "Q55AR1", "DDB_G0271792", "Q54JJ3", "DDB_G0288015", "Q54SH9", "DDB_G0282457", "Q54V41", "DDB_G0280633", "Q54V47", "DDB_G0280621", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771" ] }, "reaction_10618379": { "compartment": "compartment_20699", "id": "reaction_10618379", "reactome": "R-DDI-8847637", "name": "NSF and SNAPs bind the cis-SNARE at the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611694", "species_10611703", "species_10618375" ], "products": [ "species_10618377" ], "modifiers": [], "additional_components": [ "Q75JI3", "DDB_G0276153", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712", "Q54ZH1", "DDB_G0277565", "Q54SJ2", "DDB_G0282433", "Q54QH2", "DDB_G0283831", "Q54BK5", "DDB_G0293712", "Q54ZH1", "DDB_G0277565", "Q54SJ2", "DDB_G0282433", "Q54QH2", "DDB_G0283831", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153" ] }, "reaction_10617758": { "compartment": "compartment_20699", "id": "reaction_10617758", "reactome": "R-DDI-6811433", "name": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617754", "species_10617130" ], "products": [ "species_10617756" ], "modifiers": [], "additional_components": [ "Q553C3", "DDB_G0275765", "Q54CK6", "DDB_G0292974", "Q54R67", "DDB_G0283363", "Q54QH2", "DDB_G0283831", "Q551H5", "DDB_G0276575", "Q54PW2", "DDB_G0284185", "Q54I20", "DDB_G0289063", "Q54PQ5", "DDB_G0289063", "Q54ZH1", "DDB_G0277565", "Q54SJ2", "DDB_G0282433", "Q54GE3", "DDB_G0290213", "Q55FD0", "DDB_G0268452", "Q55GN5", "DDB_G0267590", "Q54LC8", "DDB_G0286705", "Q54C87", "DDB_G0293106", "Q54ZB3", "DDB_G0277691", "Q54UC2", "DDB_G0281163", "Q55BB8", "DDB_G0271388", "Q54HE0", "DDB_G0289535", "Q54CT0", "DDB_G0292784", "Q54TT4", "DDB_G0281511", "Q54LC8", "DDB_G0286705", "Q54C87", "DDB_G0293106", "Q54ZB3", "DDB_G0277691", "Q54UC2", "DDB_G0281163", "Q55BB8", "DDB_G0271388", "Q54HE0", "DDB_G0289535", "Q54CT0", "DDB_G0292784", "Q54TT4", "DDB_G0281511", "Q553C3", "DDB_G0275765", "Q54CK6", "DDB_G0292974", "Q54R67", "DDB_G0283363", "Q54QH2", "DDB_G0283831", "Q551H5", "DDB_G0276575", "Q54PW2", "DDB_G0284185", "Q54I20", "DDB_G0289063", "Q54PQ5", "DDB_G0289063", "Q54ZH1", "DDB_G0277565", "Q54SJ2", "DDB_G0282433", "Q54GE3", "DDB_G0290213", "Q55FD0", "DDB_G0268452", "Q55GN5", "DDB_G0267590" ] }, "reaction_10618382": { "compartment": "compartment_20699", "id": "reaction_10618382", "reactome": "R-DDI-8847638", "name": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618377", "species_113592" ], "products": [ "species_10611694", "species_10617256", "species_29370", "species_10617258", "species_10611703", "species_10617143", "species_10617254" ], "modifiers": [ [ "species_10618377", "catalyst" ] ], "additional_components": [ "Q54BK5", "DDB_G0293712", "Q54ZH1", "DDB_G0277565", "Q54SJ2", "DDB_G0282433", "Q54QH2", "DDB_G0283831", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153", "Q75JI3", "DDB_G0276153", "DDB_G0282433", "DDB_G0277565", "Q54NP6", "DDB_G0285111", "DDB_G0293712", "DDB_G0283831", "Q54BK5", "DDB_G0293712", "Q54ZH1", "DDB_G0277565", "Q54SJ2", "DDB_G0282433", "Q54QH2", "DDB_G0283831", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153" ] }, "reaction_10606649": { "compartment": "compartment_70101", "id": "reaction_10606649", "reactome": "R-DDI-5665854", "name": "ADRM1:26S proteaseome binds UCHL5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606638", "species_10606645" ], "products": [ "species_10606647" ], "modifiers": [], "additional_components": [ "DDB_G0285527", "Q556N5", "DDB_G0272624", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408", "Q556N5", "DDB_G0272624", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408", "Q54N38", "DDB_G0285527" ] }, "reaction_10611049": { "compartment": "compartment_70101", "id": "reaction_10611049", "reactome": "R-DDI-5690319", "name": "UCHL1, UCHL3 cleave ubiquitin adducts", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10611044" ], "products": [ "species_1131871", "species_10611046" ], "modifiers": [ [ "species_10611044", "catalyst" ] ], "additional_components": [ "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14797", "DDB_G0276765", "Q54T48", "DDB_G0282007", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54T48", "DDB_G0282007", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14797", "DDB_G0276765", "Q54T48", "DDB_G0282007" ] }, "reaction_10606686": { "compartment": "compartment_70101", "id": "reaction_10606686", "reactome": "R-DDI-5665871", "name": "ADRM1 binds 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577240", "species_10606643" ], "products": [ "species_10606645" ], "modifiers": [], "additional_components": [ "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408", "DDB_G0272624", "Q556N5", "DDB_G0272624", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10590556": { "compartment": "compartment_70101", "id": "reaction_10590556", "reactome": "R-DDI-391266", "name": "Association of CCT/TriC with sphingosine kinase 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590508", "species_10590552" ], "products": [ "species_10590554" ], "modifiers": [], "additional_components": [ "DDB_G0284545", "Q55BM4", "DDB_G0269190", "Q54TD3", "DDB_G0281849", "Q54ER7", "DDB_G0291225", "Q76NU3", "DDB_G0277493", "Q54ES9", "DDB_G0291358", "Q54CL2", "DDB_G0292872", "species_29370", "Q54TH8", "DDB_G0281741", "Q552J0", "DDB_G0276233", "Q55BM4", "DDB_G0269190", "Q54TD3", "DDB_G0281849", "Q54ER7", "DDB_G0291225", "Q76NU3", "DDB_G0277493", "Q54ES9", "DDB_G0291358", "Q54CL2", "DDB_G0292872", "species_29370", "Q54TH8", "DDB_G0281741", "Q552J0", "DDB_G0276233", "Q6B516", "DDB_G0284545" ] }, "reaction_10617873": { "compartment": "compartment_70101", "id": "reaction_10617873", "reactome": "R-DDI-6814119", "name": "TRiC/CCT binds unfolded G-protein beta subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590552", "species_10589812" ], "products": [ "species_10617871" ], "modifiers": [], "additional_components": [ "Q55BM4", "DDB_G0269190", "Q54TD3", "DDB_G0281849", "Q54ER7", "DDB_G0291225", "Q76NU3", "DDB_G0277493", "Q54ES9", "DDB_G0291358", "Q54CL2", "DDB_G0292872", "species_29370", "Q54TH8", "DDB_G0281741", "Q552J0", "DDB_G0276233", "DDB_G0277143", "P36408", "DDB_G0277143", "Q55BM4", "DDB_G0269190", "Q54TD3", "DDB_G0281849", "Q54ER7", "DDB_G0291225", "Q76NU3", "DDB_G0277493", "Q54ES9", "DDB_G0291358", "Q54CL2", "DDB_G0292872", "species_29370", "Q54TH8", "DDB_G0281741", "Q552J0", "DDB_G0276233" ] }, "reaction_10617879": { "compartment": "compartment_70101", "id": "reaction_10617879", "reactome": "R-DDI-6814120", "name": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617877" ], "products": [ "species_10617871", "species_29372" ], "modifiers": [], "additional_components": [ "Q55BM4", "DDB_G0269190", "Q54TD3", "DDB_G0281849", "Q54ER7", "DDB_G0291225", "Q76NU3", "DDB_G0277493", "Q54ES9", "DDB_G0291358", "species_113592", "Q54CL2", "DDB_G0292872", "Q54TH8", "DDB_G0281741", "Q552J0", "DDB_G0276233", "P36408", "DDB_G0277143", "P36408", "DDB_G0277143", "Q55BM4", "DDB_G0269190", "Q54TD3", "DDB_G0281849", "Q54ER7", "DDB_G0291225", "Q76NU3", "DDB_G0277493", "Q54ES9", "DDB_G0291358", "Q54CL2", "DDB_G0292872", "species_29370", "Q54TH8", "DDB_G0281741", "Q552J0", "DDB_G0276233" ] }, "reaction_10617881": { "compartment": "compartment_70101", "id": "reaction_10617881", "reactome": "R-DDI-6814124", "name": "ATP binds G-protein beta associated TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617871", "species_113592" ], "products": [ "species_29370", "species_10617877" ], "modifiers": [], "additional_components": [ "P36408", "DDB_G0277143", "Q55BM4", "DDB_G0269190", "Q54TD3", "DDB_G0281849", "Q54ER7", "DDB_G0291225", "Q76NU3", "DDB_G0277493", "Q54ES9", "DDB_G0291358", "Q54CL2", "DDB_G0292872", "species_29370", "Q54TH8", "DDB_G0281741", "Q552J0", "DDB_G0276233", "Q55BM4", "DDB_G0269190", "Q54TD3", "DDB_G0281849", "Q54ER7", "DDB_G0291225", "Q76NU3", "DDB_G0277493", "Q54ES9", "DDB_G0291358", "species_113592", "Q54CL2", "DDB_G0292872", "Q54TH8", "DDB_G0281741", "Q552J0", "DDB_G0276233", "P36408", "DDB_G0277143" ] }, "reaction_10611316": { "compartment": "compartment_984", "id": "reaction_10611316", "reactome": "R-DDI-5693346", "name": "CECRI deaminates Ade-Rib to Ino", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_83908" ], "products": [ "species_2022135", "species_83921" ], "modifiers": [ [ "species_10611313", "catalyst" ] ], "additional_components": [ "species_29426", "Q553U5", "DDB_G0275179" ] }, "reaction_10608345": { "compartment": "compartment_3828046", "id": "reaction_10608345", "reactome": "R-DDI-5684864", "name": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5685882", "species_10608214" ], "products": [ "species_10608286", "species_10608238", "species_10608262" ], "modifiers": [ [ "species_10608342", "catalyst" ] ], "additional_components": [ "B0G0Z4", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q55EI1", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q54SX7", "DDB_G0292508", "Q54WE0", "DDB_G0279713", "Q54WE4", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q54SX7", "DDB_G0292508", "Q54WE0", "DDB_G0279713", "Q54WE4", "DDB_G0292508", "B0G0Z4", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q55EI1", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q54SX7", "DDB_G0292508", "Q54WE0", "DDB_G0279713", "Q54WE4", "DDB_G0292508", "B0G0Z4", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q55EI1", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "B0G0Z4", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q55EI1", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q54SX7", "DDB_G0292508", "Q54WE0", "DDB_G0279713", "Q54WE4", "DDB_G0292508", "P04989", "DDB_G0279799", "Q23894", "DDB_G0283867", "Q54RQ2", "DDB_G0282991", "Q54TR1", "DDB_G0281605", "Q54UH2", "DDB_G0282991", "Q54UH3", "DDB_G0282991", "Q86KD4", "DDB_G0282991", "O76856", "DDB_G0279411" ] }, "reaction_10612937": { "compartment": "compartment_3828046", "id": "reaction_10612937", "reactome": "R-DDI-6791016", "name": "SFTPB binds itself", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608238" ], "products": [ "species_10608347" ], "modifiers": [], "additional_components": [ "Q54LG3", "DDB_G0292508", "Q54SX7", "DDB_G0292508", "Q54WE0", "DDB_G0279713", "Q54WE4", "DDB_G0292508", "B0G0Z4", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q55EI1", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q54SX7", "DDB_G0292508", "Q54WE0", "DDB_G0279713", "Q54WE4", "DDB_G0292508", "B0G0Z4", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q55EI1", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508" ] }, "reaction_10626233": { "compartment": "compartment_12045", "id": "reaction_10626233", "reactome": "R-DDI-9624789", "name": "pro-SFTPB translocates from ER membrane to multivesicle body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626231" ], "products": [ "species_10608214" ], "modifiers": [], "additional_components": [ "Q54C60", "DDB_G0293010", "Q55EI1", "DDB_G0292508", "B0G0Z4", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54SX7", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q54WE4", "DDB_G0292508", "Q54WE0", "DDB_G0279713", "B0G0Z4", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q55EI1", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q54SX7", "DDB_G0292508", "Q54WE0", "DDB_G0279713", "Q54WE4", "DDB_G0292508" ] }, "reaction_10608074": { "compartment": "compartment_2133233", "id": "reaction_10608074", "reactome": "R-DDI-5683714", "name": "ABCA3 transports PC, PG from ER membrane to lamellar body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5684863" ], "products": [ "species_29372", "species_29370", "species_5684869" ], "modifiers": [ [ "species_10608071", "catalyst" ] ], "additional_components": [ "species_426925", "species_1483256", "species_426925", "species_1483256", "Q8T6J1", "DDB_G0291245", "Q8T6J2", "DDB_G0274119", "Q8T6J5", "DDB_G0267438", "Q54BT5", "DDB_G0293436", "Q555Z5", "DDB_G0274121", "Q55BC0", "DDB_G0271138", "Q8T5Z7", "DDB_G0291994" ] }, "reaction_10592403": { "compartment": "compartment_1462052", "id": "reaction_10592403", "reactome": "R-DDI-437085", "name": "ZnT5 transports zinc into secretory granules in pancreatic beta cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216785" ], "modifiers": [ [ "species_10592400", "catalyst" ] ], "additional_components": [ "Q54F34", "DDB_G0291141", "Q55E98", "DDB_G0291141" ] }, "reaction_10592411": { "compartment": "compartment_20699", "id": "reaction_10592411", "reactome": "R-DDI-437136", "name": "SLC30A8 transports Zn2+ from cytosol to secretory granule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216785" ], "modifiers": [ [ "species_10592408", "catalyst" ] ], "additional_components": [ "DDB_G0283629" ] }, "reaction_10589007": { "compartment": "compartment_876", "id": "reaction_10589007", "reactome": "R-DDI-265177", "name": "Exocyst complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10588988", "species_10588973", "species_10589003", "species_10588968", "species_10588998", "species_10588983", "species_10588978", "species_10588993" ], "products": [ "species_10589005" ], "modifiers": [], "additional_components": [ "DDB_G0279991", "DDB_G0280081", "DDB_G0272991", "DDB_G0284833", "DDB_G0293520", "DDB_G0293936", "DDB_G0287881", "DDB_G0285067", "Q54NV1", "DDB_G0285067", "B0G163", "DDB_G0287881", "Q54B27", "DDB_G0293936", "Q54BP6", "DDB_G0293520", "Q54P76", "DDB_G0284833", "Q558Z9", "DDB_G0272991", "Q54VX5", "DDB_G0280081", "Q54VZ8", "DDB_G0279991" ] }, "reaction_10599268": { "compartment": "compartment_70101", "id": "reaction_10599268", "reactome": "R-DDI-1799332", "name": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599262", "species_10599264" ], "products": [ "species_10599266" ], "modifiers": [], "additional_components": [ "Q556L1", "DDB_G0272590", "Q54EP7", "DDB_G0291412", "Q55GL2", "DDB_G0267622", "Q554G7", "DDB_G0275211", "Q75K18", "DDB_G0275455", "Q1ZXE8", "DDB_G0285821", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q556L1", "DDB_G0272590", "Q54EP7", "DDB_G0291412", "Q55GL2", "DDB_G0267622", "Q554G7", "DDB_G0275211", "Q75K18", "DDB_G0275455", "Q1ZXE8", "DDB_G0285821" ] }, "reaction_10583761": { "compartment": "compartment_70101", "id": "reaction_10583761", "reactome": "R-DDI-156913", "name": "Regeneration of eEF1A:GTP by eEF1B activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10583756", "species_10583752" ], "products": [ "species_10583758", "species_10583738" ], "modifiers": [ [ "species_10583752", "catalyst" ] ], "additional_components": [ "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "species_29420", "Q9GRF8", "DDB_G0284035", "B0G141", "DDB_G0282979", "Q9GRF8", "DDB_G0284035", "B0G141", "DDB_G0282979", "species_29420", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "species_29438", "Q9GRF8", "DDB_G0284035", "B0G141", "DDB_G0282979" ] }, "reaction_10583771": { "compartment": "compartment_70101", "id": "reaction_10583771", "reactome": "R-DDI-156930", "name": "GTP-binding activates eEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10583767" ], "products": [ "species_10583769" ], "modifiers": [], "additional_components": [ "DDB_G0288373", "P15112", "DDB_G0288373", "species_29438" ] }, "reaction_10583754": { "compartment": "compartment_70101", "id": "reaction_10583754", "reactome": "R-DDI-156910", "name": "Formation of eEF1B complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583743", "species_10583750", "species_10583745" ], "products": [ "species_10583752" ], "modifiers": [], "additional_components": [ "DDB_G0284035", "DDB_G0282979", "DDB_G0284035", "Q9GRF8", "DDB_G0284035", "B0G141", "DDB_G0282979" ] }, "reaction_10583720": { "compartment": "compartment_70101", "id": "reaction_10583720", "reactome": "R-DDI-156823", "name": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583711", "species_10583716" ], "products": [ "species_10583718" ], "modifiers": [], "additional_components": [ "Q75K16", "DDB_G0275459", "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "Q54BM2", "DDB_G0293558", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "DDB_G0275881", "Q553M7", "DDB_G0275881", "Q75K16", "DDB_G0275459", "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "Q54BM2", "DDB_G0293558", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395" ] }, "reaction_10583724": { "compartment": "compartment_70101", "id": "reaction_10583724", "reactome": "R-DDI-156826", "name": "Dissociation of L13a from the 60s ribosomal subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580367" ], "products": [ "species_10583722", "species_10580149" ], "modifiers": [], "additional_components": [ "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "DDB_G0275881" ] }, "reaction_10580065": { "compartment": "compartment_70101", "id": "reaction_10580065", "reactome": "R-DDI-72631", "name": "Formation of the cap-binding eIF4F complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580029", "species_10580024", "species_10580019" ], "products": [ "species_10580031" ], "modifiers": [], "additional_components": [ "DDB_G0275395", "DDB_G0268574", "P90529", "DDB_G0269146", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395" ] }, "reaction_10583713": { "compartment": "compartment_70101", "id": "reaction_10583713", "reactome": "R-DDI-156808", "name": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583709", "species_10583704", "species_10580008", "species_10579985" ], "products": [ "species_10583711", "species_10579985" ], "modifiers": [], "additional_components": [ "DDB_G0293558", "Q75K16", "DDB_G0275459", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "DDB_G0278205", "Q75K16", "DDB_G0275459", "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "Q54BM2", "DDB_G0293558", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "DDB_G0278205" ] }, "reaction_10583773": { "compartment": "compartment_70101", "id": "reaction_10583773", "reactome": "R-DDI-157849", "name": "Formation of translation initiation complexes containing mRNA that does not circularize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580008", "species_10580071", "species_10579985" ], "products": [ "species_10580040", "species_10579985" ], "modifiers": [], "additional_components": [ "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "Q75K16", "DDB_G0275459", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "DDB_G0278205", "Q75K16", "DDB_G0275459", "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "DDB_G0278205" ] }, "reaction_10580074": { "compartment": "compartment_70101", "id": "reaction_10580074", "reactome": "R-DDI-72647", "name": "Cap-bound mRNA is activated by helicases ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10580038", "species_10580036", "species_10580069", "species_10580019" ], "products": [ "species_29372", "species_29370", "species_10580071", "species_10580019", "species_72595" ], "modifiers": [ [ "species_10580019", "catalyst" ] ], "additional_components": [ "DDB_G0275459", "DDB_G0275459", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "P90529", "DDB_G0269146", "Q75K16", "DDB_G0275459", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "P90529", "DDB_G0269146", "P90529", "DDB_G0269146" ] }, "reaction_10580063": { "compartment": "compartment_70101", "id": "reaction_10580063", "reactome": "R-DDI-72622", "name": "Release of eIF4E from the inactive eIF4E:4E-BP complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580061" ], "products": [ "species_10580059", "species_10580024" ], "modifiers": [], "additional_components": [ "Q55FE0", "DDB_G0268574", "Q54DU8", "DDB_G0291990", "DDB_G0291990", "DDB_G0268574" ] }, "reaction_10580054": { "compartment": "compartment_70101", "id": "reaction_10580054", "reactome": "R-DDI-72621", "name": "Ribosomal scanning ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10580040" ], "products": [ "species_29372", "species_29370", "species_10580040" ], "modifiers": [ [ "species_72617", "catalyst" ], [ "species_113592", "catalyst" ] ], "additional_components": [ "Q75K16", "DDB_G0275459", "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "Q75K16", "DDB_G0275459", "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395" ] }, "reaction_10580396": { "compartment": "compartment_70101", "id": "reaction_10580396", "reactome": "R-DDI-72697", "name": "Start codon recognition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580045", "species_10580040", "species_72617", "species_10580002", "species_10579985" ], "products": [ "species_10580045", "species_10580040", "species_72617", "species_10580002", "species_10579985" ], "modifiers": [ [ "species_72617", "catalyst" ] ], "additional_components": [ "DDB_G0286753", "Q75K16", "DDB_G0275459", "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "DDB_G0278205", "DDB_G0286753", "Q75K16", "DDB_G0275459", "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "DDB_G0278205" ] }, "reaction_10580394": { "compartment": "compartment_70101", "id": "reaction_10580394", "reactome": "R-DDI-72691", "name": "Formation of the 43S pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580390", "species_10580006" ], "products": [ "species_10580008" ], "modifiers": [], "additional_components": [ "Q54YJ6", "DDB_G0278205", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254" ] }, "reaction_10580076": { "compartment": "compartment_70101", "id": "reaction_10580076", "reactome": "R-DDI-72663", "name": "De novo formation of eIF2:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10580002" ], "products": [ "species_10580004" ], "modifiers": [], "additional_components": [ "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438" ] }, "reaction_10580078": { "compartment": "compartment_70101", "id": "reaction_10580078", "reactome": "R-DDI-72669", "name": "Met-tRNAi binds to eIF2:GTP to form the ternary complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_72393", "species_10580004" ], "products": [ "species_10580006" ], "modifiers": [ [ "species_29438", "catalyst" ] ], "additional_components": [ "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438" ] }, "reaction_10580384": { "compartment": "compartment_70101", "id": "reaction_10580384", "reactome": "R-DDI-72671", "name": "eIF5B:GTP is hydrolyzed and released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580378" ], "products": [ "species_10580382", "species_10580380", "species_29372" ], "modifiers": [], "additional_components": [ "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54XP6", "DDB_G0278815", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54XP6", "DDB_G0278815", "species_29420" ] }, "reaction_10580051": { "compartment": "compartment_70101", "id": "reaction_10580051", "reactome": "R-DDI-72619", "name": "eIF2:GTP is hydrolyzed, eIFs are released ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580045", "species_10580040", "species_72617" ], "products": [ "species_10580047", "species_10579980", "species_10580029", "species_10580045", "species_29372", "species_10580024", "species_10580038", "species_10580036", "species_10580019", "species_10579985", "species_10580049" ], "modifiers": [ [ "species_10580045", "catalyst" ] ], "additional_components": [ "DDB_G0286753", "Q75K16", "DDB_G0275459", "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "DDB_G0275395", "DDB_G0286753", "DDB_G0268574", "DDB_G0275459", "DDB_G0275459", "P90529", "DDB_G0269146", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29420", "DDB_G0286753" ] }, "reaction_10580386": { "compartment": "compartment_70101", "id": "reaction_10580386", "reactome": "R-DDI-72672", "name": "The 60S subunit joins the translation initiation complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580047", "species_10580367", "species_10580376" ], "products": [ "species_10580378" ], "modifiers": [], "additional_components": [ "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54XP6", "DDB_G0278815", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54XP6", "DDB_G0278815", "species_29438" ] }, "reaction_10580388": { "compartment": "compartment_70101", "id": "reaction_10580388", "reactome": "R-DDI-72673", "name": "Release of 40S and 60S subunits from the 80S ribosome ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10579985", "species_10580369" ], "products": [ "species_10580367", "species_10579913", "species_10579985" ], "modifiers": [], "additional_components": [ "DDB_G0278205", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "DDB_G0278205" ] }, "reaction_10580392": { "compartment": "compartment_70101", "id": "reaction_10580392", "reactome": "R-DDI-72676", "name": "eIF3 and eIF1A bind to the 40S subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10579980", "species_10579913", "species_10579985" ], "products": [ "species_10580390" ], "modifiers": [], "additional_components": [ "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "DDB_G0278205", "Q54YJ6", "DDB_G0278205", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254" ] }, "reaction_10593013": { "compartment": "compartment_5460", "id": "reaction_10593013", "reactome": "R-DDI-449937", "name": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159450", "species_113521" ], "products": [ "species_113548" ], "modifiers": [ [ "species_10593010", "catalyst" ], [ "species_109496", "catalyst" ] ], "additional_components": [ "Q54PV8", "DDB_G0284265" ] }, "reaction_10578737": { "compartment": "compartment_70101", "id": "reaction_10578737", "reactome": "R-DDI-71732", "name": "pyrophosphate + H2O => 2 orthophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111294", "species_29356" ], "products": [ "species_29372" ], "modifiers": [ [ "species_10578734", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54PV8", "DDB_G0284265" ] }, "reaction_10601713": { "compartment": "compartment_7660", "id": "reaction_10601713", "reactome": "R-DDI-2993763", "name": "SENP1,2,5 proteolytically process SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601709" ], "products": [ "species_10601711" ], "modifiers": [ [ "species_10601673", "catalyst" ] ], "additional_components": [ "DDB_G0282161", "DDB_G0282161", "Q54DG4", "DDB_G0292290" ] }, "reaction_10601685": { "compartment": "compartment_7660", "id": "reaction_10601685", "reactome": "R-DDI-2990842", "name": "SENP1,2,5 proteolytically process SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601681" ], "products": [ "species_10601683" ], "modifiers": [ [ "species_10601673", "catalyst" ] ], "additional_components": [ "DDB_G0282161", "DDB_G0282161", "Q54DG4", "DDB_G0292290" ] }, "reaction_10601676": { "compartment": "compartment_7660", "id": "reaction_10601676", "reactome": "R-DDI-2990840", "name": "SENP1,2,5 proteolytically process SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601662" ], "products": [ "species_10594213" ], "modifiers": [ [ "species_10601673", "catalyst" ] ], "additional_components": [ "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q54DG4", "DDB_G0292290" ] }, "reaction_10601746": { "compartment": "compartment_7660", "id": "reaction_10601746", "reactome": "R-DDI-2993780", "name": "Transfer of SUMO1 from E1 to UBE2I (UBC9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601725", "species_10601653" ], "products": [ "species_10601743", "species_10601638" ], "modifiers": [ [ "species_10601638", "catalyst" ] ], "additional_components": [ "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54L40", "DDB_G0286919", "Q54WI4", "DDB_G0279641", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54L40", "DDB_G0286919", "Q54WI4", "DDB_G0279641", "Q54L40", "DDB_G0286919", "Q54WI4", "DDB_G0279641" ] }, "reaction_10601656": { "compartment": "compartment_7660", "id": "reaction_10601656", "reactome": "R-DDI-2990833", "name": "Conjugation of SUMO1 to UBA2:SAE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10601638", "species_10594213" ], "products": [ "species_164121", "species_10601653", "species_113541" ], "modifiers": [ [ "species_10601638", "catalyst" ] ], "additional_components": [ "Q54L40", "DDB_G0286919", "Q54WI4", "DDB_G0279641", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54L40", "DDB_G0286919", "Q54WI4", "DDB_G0279641", "Q54L40", "DDB_G0286919", "Q54WI4", "DDB_G0279641" ] }, "reaction_10603971": { "compartment": "compartment_7660", "id": "reaction_10603971", "reactome": "R-DDI-4570496", "name": "SUMOylation of Histone H4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10581418" ], "products": [ "species_10601725", "species_10603969" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0276863", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q76NW2", "DDB_G0276863", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10604098": { "compartment": "compartment_7660", "id": "reaction_10604098", "reactome": "R-DDI-4616015", "name": "SUMOylation of HDAC2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10603140" ], "products": [ "species_10601725", "species_10604096" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0268024", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q55FN5", "DDB_G0268024", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10604058": { "compartment": "compartment_7660", "id": "reaction_10604058", "reactome": "R-DDI-4615889", "name": "SUMOylation of HDAC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10597270" ], "products": [ "species_10601725", "species_10604056" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0268024", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q55FN5", "DDB_G0268024", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10603949": { "compartment": "compartment_7660", "id": "reaction_10603949", "reactome": "R-DDI-4570485", "name": "SUMOylation of Histone H4 with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581418", "species_10601799" ], "products": [ "species_10601725", "species_10603947" ], "modifiers": [ [ "species_10601799", "catalyst" ] ], "additional_components": [ "DDB_G0276863", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "DDB_G0276863", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161" ] }, "reaction_10603395": { "compartment": "compartment_7660", "id": "reaction_10603395", "reactome": "R-DDI-3900194", "name": "PIAS1 SUMOylates DDX5 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601786", "species_10579094" ], "products": [ "species_10601725", "species_10603392" ], "modifiers": [ [ "species_10594201", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q54SX2", "DDB_G0282161", "DDB_G0293168", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "DDB_G0293168", "Q54V57", "DDB_G0280603", "Q555X5", "DDB_G0274743" ] }, "reaction_10603490": { "compartment": "compartment_7660", "id": "reaction_10603490", "reactome": "R-DDI-4085992", "name": "SUMOylation of DAXX with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10602165" ], "products": [ "species_10601725", "species_10603488" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0279509", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54WP8", "DDB_G0279509", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10603511": { "compartment": "compartment_7660", "id": "reaction_10603511", "reactome": "R-DDI-4085994", "name": "TOPORS SUMOylates SIN3A with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10590689" ], "products": [ "species_10603503", "species_10601725" ], "modifiers": [ [ "species_10603508", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0281045", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54UJ3", "DDB_G0281045", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "DDB_G0281183" ] }, "reaction_10603528": { "compartment": "compartment_7660", "id": "reaction_10603528", "reactome": "R-DDI-4086083", "name": "SUMOylation of ING2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10603513" ], "products": [ "species_10601725", "species_10603526" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0284411", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54PN9", "DDB_G0284411", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10603563": { "compartment": "compartment_7660", "id": "reaction_10603563", "reactome": "R-DDI-4090284", "name": "SUMOylation of HIPK2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10603548" ], "products": [ "species_10601725", "species_10603561" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0283605", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q54QV3", "DDB_G0283605", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10603389": { "compartment": "compartment_7660", "id": "reaction_10603389", "reactome": "R-DDI-3900177", "name": "SUMOylation of DDX5 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10579094" ], "products": [ "species_10601725", "species_10603387" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0293168", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54CE0", "DDB_G0293168", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10603374": { "compartment": "compartment_7660", "id": "reaction_10603374", "reactome": "R-DDI-3900047", "name": "SUMOylation of DDX17 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10603354" ], "products": [ "species_10603372", "species_10601725" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54CB8", "DDB_G0293064", "Q54CE0", "DDB_G0293168", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q54CB8", "DDB_G0293064", "Q54CE0", "DDB_G0293168", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10604146": { "compartment": "compartment_7660", "id": "reaction_10604146", "reactome": "R-DDI-4641345", "name": "SUMOylation of TOP2B with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10604127" ], "products": [ "species_10601725", "species_10604144" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "P90520", "DDB_G0279737", "Q55BP5", "DDB_G0270418", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "P90520", "DDB_G0279737", "Q55BP5", "DDB_G0270418", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10604151": { "compartment": "compartment_7660", "id": "reaction_10604151", "reactome": "R-DDI-4641350", "name": "PIAS4 SUMOylates TOP2A with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601801", "species_10604103" ], "products": [ "species_10601725", "species_10604149" ], "modifiers": [ [ "species_10601810", "catalyst" ] ], "additional_components": [ "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161", "DDB_G0270418", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "DDB_G0270418", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10604118": { "compartment": "compartment_7660", "id": "reaction_10604118", "reactome": "R-DDI-4641342", "name": "SUMOylation of TOP2A with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10604103" ], "products": [ "species_10601725", "species_10604116" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0270418", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q55BP5", "DDB_G0270418", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10604075": { "compartment": "compartment_7660", "id": "reaction_10604075", "reactome": "R-DDI-4615910", "name": "SUMOylation of PCNA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10577429" ], "products": [ "species_10601725", "species_10604073" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0287607", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q54K47", "DDB_G0287607", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10604171": { "compartment": "compartment_7660", "id": "reaction_10604171", "reactome": "R-DDI-4641362", "name": "SUMOylation of TOP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10604156" ], "products": [ "species_10601725", "species_10604169" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0283205", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54RC3", "DDB_G0283205", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10604001": { "compartment": "compartment_7660", "id": "reaction_10604001", "reactome": "R-DDI-4570553", "name": "SUMOylation of MDC1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603996", "species_10601801" ], "products": [ "species_10603999", "species_10601725" ], "modifiers": [ [ "species_10601801", "catalyst" ] ], "additional_components": [ "DDB_G0272690", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161", "DDB_G0272690", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161" ] }, "reaction_10603872": { "compartment": "compartment_7660", "id": "reaction_10603872", "reactome": "R-DDI-4568848", "name": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10603852" ], "products": [ "species_10601725", "species_10603865" ], "modifiers": [ [ "species_10603869", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0278203", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54YJ7", "DDB_G0278203", "Q54V57", "DDB_G0280603", "Q555X5", "DDB_G0274743" ] }, "reaction_10603847": { "compartment": "compartment_7660", "id": "reaction_10603847", "reactome": "R-DDI-4551768", "name": "PIAS4 SUMOylates PARP1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600664", "species_10601801" ], "products": [ "species_10601725", "species_10603845" ], "modifiers": [ [ "species_10601810", "catalyst" ] ], "additional_components": [ "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54HY5", "DDB_G0289141", "Q8I7C6", "DDB_G0292820", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10601830": { "compartment": "compartment_7660", "id": "reaction_10601830", "reactome": "R-DDI-2997709", "name": "PIAS1,4 SUMOylates BRCA1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10601773" ], "products": [ "species_10601725", "species_10601828" ], "modifiers": [ [ "species_10601812", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0293300", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q54C05", "DDB_G0293300", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10603718": { "compartment": "compartment_7660", "id": "reaction_10603718", "reactome": "R-DDI-4551604", "name": "PIAS4 SUMOylates PARP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10600664" ], "products": [ "species_10601725", "species_10603716" ], "modifiers": [ [ "species_10601810", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54HY5", "DDB_G0289141", "Q8I7C6", "DDB_G0292820", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10601901": { "compartment": "compartment_7660", "id": "reaction_10601901", "reactome": "R-DDI-3000383", "name": "UBE2I, HDAC7 SUMOylate PML with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10601869" ], "products": [ "species_10601884", "species_10601725" ], "modifiers": [ [ "species_10601898", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0285989", "Q54MF7", "DDB_G0285989", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54VQ7", "DDB_G0280195", "Q54X15", "DDB_G0279267", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153" ] }, "reaction_10602028": { "compartment": "compartment_7660", "id": "reaction_10602028", "reactome": "R-DDI-3108212", "name": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10601093" ], "products": [ "species_10601725", "species_10601992" ], "modifiers": [ [ "species_10602025", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54QR0", "DDB_G0283681", "Q54E85", "DDB_G0291752", "Q552D9", "DDB_G0276101", "Q550H7", "DDB_G0276977", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54QR0", "DDB_G0283681", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q550H7", "DDB_G0276977", "Q54E85", "DDB_G0291752", "Q552D9", "DDB_G0276101", "Q54HN3", "DDB_G0289341", "Q54T56", "DDB_G0281991", "Q54FE3", "DDB_G0290919", "Q54PA3", "DDB_G0284679", "Q54X37", "DDB_G0279231", "Q54I56", "DDB_G0288993" ] }, "reaction_10603823": { "compartment": "compartment_7660", "id": "reaction_10603823", "reactome": "R-DDI-4551724", "name": "PIAS4 SUMOylates HERC2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10603779" ], "products": [ "species_10601725", "species_10603821" ], "modifiers": [ [ "species_10601810", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54Q89", "DDB_G0284033", "Q8MP76", "DDB_G0284033", "Q54R64", "DDB_G0284033", "Q54S74", "DDB_G0284033", "Q54SA3", "DDB_G0284033", "Q54WU2", "DDB_G0284033", "Q55CR5", "DDB_G0284033", "Q55DD2", "DDB_G0284033", "B0G136", "DDB_G0284033", "Q55GN7", "DDB_G0284033", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54Q89", "DDB_G0284033", "Q55CR5", "DDB_G0284033", "Q55DD2", "DDB_G0284033", "Q54R64", "DDB_G0284033", "Q54S74", "DDB_G0284033", "Q55GN7", "DDB_G0284033", "Q8MP76", "DDB_G0284033", "Q54SA3", "DDB_G0284033", "Q54WU2", "DDB_G0284033", "B0G136", "DDB_G0284033", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10603889": { "compartment": "compartment_7660", "id": "reaction_10603889", "reactome": "R-DDI-4568863", "name": "SUMOylation of RAD52 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10581772" ], "products": [ "species_10603887", "species_10601725" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0269406", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q55E38", "DDB_G0269406", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10604016": { "compartment": "compartment_7660", "id": "reaction_10604016", "reactome": "R-DDI-4570554", "name": "SUMOylation of MDC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10603996" ], "products": [ "species_10604014", "species_10601725" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0272690", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q86IG6", "DDB_G0272690", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10601815": { "compartment": "compartment_7660", "id": "reaction_10601815", "reactome": "R-DDI-2997616", "name": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601773", "species_10601801" ], "products": [ "species_10601804", "species_10601725" ], "modifiers": [ [ "species_10601812", "catalyst" ] ], "additional_components": [ "DDB_G0293300", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161", "DDB_G0293300", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10603991": { "compartment": "compartment_7660", "id": "reaction_10603991", "reactome": "R-DDI-4570528", "name": "SUMOylation of XPC with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10603976" ], "products": [ "species_10601725", "species_10603989" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0292296", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q1ZXA6", "DDB_G0292296", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10601914": { "compartment": "compartment_7660", "id": "reaction_10601914", "reactome": "R-DDI-3000433", "name": "SUMOylation of PML with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601869", "species_10601799" ], "products": [ "species_10601725", "species_10601911" ], "modifiers": [ [ "species_10601799", "catalyst" ] ], "additional_components": [ "DDB_G0285989", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "DDB_G0285989", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161" ] }, "reaction_10603903": { "compartment": "compartment_7660", "id": "reaction_10603903", "reactome": "R-DDI-4568914", "name": "SUMOylation of BLM with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601801", "species_10603894" ], "products": [ "species_10603900", "species_10601725" ], "modifiers": [ [ "species_10601801", "catalyst" ] ], "additional_components": [ "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161", "DDB_G0292130", "DDB_G0292130", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161" ] }, "reaction_10602897": { "compartment": "compartment_7660", "id": "reaction_10602897", "reactome": "R-DDI-3465545", "name": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602878", "species_10601801" ], "products": [ "species_10601725", "species_10602886" ], "modifiers": [ [ "species_10602894", "catalyst" ] ], "additional_components": [ "Q1ZXA2", "DDB_G0293468", "Q54MS4", "DDB_G0285693", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q1ZXA2", "DDB_G0293468", "Q54MS4", "DDB_G0285693", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10601851": { "compartment": "compartment_7660", "id": "reaction_10601851", "reactome": "R-DDI-2997723", "name": "PIAS4 SUMOylates TP53BP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10601835" ], "products": [ "species_10601725", "species_10601848" ], "modifiers": [ [ "species_10601810", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0286539", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54LN0", "DDB_G0286539", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10603474": { "compartment": "compartment_7660", "id": "reaction_10603474", "reactome": "R-DDI-4085350", "name": "SUMOylation of UBE2I with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10601725" ], "products": [ "species_10601725", "species_10603472" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10603446": { "compartment": "compartment_7660", "id": "reaction_10603446", "reactome": "R-DDI-3968362", "name": "SUMOylation of PIAS4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10601810" ], "products": [ "species_10601725", "species_10603444" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10603757": { "compartment": "compartment_7660", "id": "reaction_10603757", "reactome": "R-DDI-4551683", "name": "SUMOylation of TOPORS with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10603508" ], "products": [ "species_10601725", "species_10603755" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0281183", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54UA7", "DDB_G0281183", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10620075": { "compartment": "compartment_70101", "id": "reaction_10620075", "reactome": "R-DDI-8867370", "name": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589898", "species_113592", "species_29424" ], "products": [ "species_10620063", "species_29372", "species_29370" ], "modifiers": [ [ "species_10620072", "catalyst" ] ], "additional_components": [ "species_29438", "species_29420", "species_29438", "species_29420", "Q54TU1", "DDB_G0281541" ] }, "reaction_10623090": { "compartment": "compartment_70101", "id": "reaction_10623090", "reactome": "R-DDI-8938815", "name": "RNF152 polyubiquitinates RRAGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623077", "species_10623079" ], "products": [ "species_10623087", "species_10623070", "species_10587616" ], "modifiers": [ [ "species_10623079", "catalyst" ] ], "additional_components": [ "Q86K32", "DDB_G0277267", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54IK1", "DDB_G0288701", "species_29420", "Q86K32", "DDB_G0277267", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54L05", "DDB_G0286991", "species_29420", "Q54IK1", "DDB_G0288701", "DDB_G0286991", "DDB_G0277267", "Q54IK1", "DDB_G0288701", "species_29420", "Q86K32", "DDB_G0277267", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54L05", "DDB_G0286991" ] }, "reaction_10623282": { "compartment": "compartment_7660", "id": "reaction_10623282", "reactome": "R-DDI-8943007", "name": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623255", "species_10623270", "species_10623264", "species_10612435" ], "products": [ "species_10623272" ], "modifiers": [], "additional_components": [ "DDB_G0287171", "Q86K32", "DDB_G0277267", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54D06", "DDB_G0292596", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54KQ4", "DDB_G0287171" ] }, "reaction_10623906": { "compartment": "compartment_17947", "id": "reaction_10623906", "reactome": "R-DDI-8953917", "name": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623900", "species_10623902" ], "products": [ "species_10623904" ], "modifiers": [], "additional_components": [ "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54MD1", "DDB_G0286033", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54MD1", "DDB_G0286033" ] }, "reaction_10623280": { "compartment": "compartment_7660", "id": "reaction_10623280", "reactome": "R-DDI-8943003", "name": "SHPRH polyubiquitinates monoubiquitinated PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623272", "species_10623270" ], "products": [ "species_10623277", "species_10623255", "species_10623264", "species_10608545" ], "modifiers": [ [ "species_10623272", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54KQ4", "DDB_G0287171", "Q86K32", "DDB_G0277267", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54D06", "DDB_G0292596", "Q54K47", "DDB_G0287607", "DDB_G0287171", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54KQ4", "DDB_G0287171" ] }, "reaction_10623062": { "compartment": "compartment_70101", "id": "reaction_10623062", "reactome": "R-DDI-8938770", "name": "RNF144A binds PRKDC and Ubiquitin:UBE2L3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623047", "species_10623056", "species_10623058" ], "products": [ "species_10623060" ], "modifiers": [], "additional_components": [ "DDB_G0281167", "Q54ZG5", "DDB_G0277577", "Q54QC7", "DDB_G0283939", "Q54TE1", "DDB_G0281833", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54TE1", "DDB_G0281833", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54ZG5", "DDB_G0277577", "Q54QC7", "DDB_G0283939", "Q54UC0", "DDB_G0281167" ] }, "reaction_10623092": { "compartment": "compartment_70101", "id": "reaction_10623092", "reactome": "R-DDI-8938829", "name": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623070", "species_10623077", "species_10623072" ], "products": [ "species_10623079" ], "modifiers": [], "additional_components": [ "DDB_G0286991", "Q86K32", "DDB_G0277267", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54IK1", "DDB_G0288701", "species_29420", "Q54IK1", "DDB_G0288701", "species_29420", "Q86K32", "DDB_G0277267", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54L05", "DDB_G0286991" ] }, "reaction_10623306": { "compartment": "compartment_7660", "id": "reaction_10623306", "reactome": "R-DDI-8943041", "name": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623270", "species_10623264", "species_10612435", "species_10623299" ], "products": [ "species_10623301" ], "modifiers": [], "additional_components": [ "Q86K32", "DDB_G0277267", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54D06", "DDB_G0292596", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "Q54T24", "DDB_G0281949", "B0G105", "DDB_G0282115", "Q54SZ4", "DDB_G0282115", "Q54T24", "DDB_G0281949", "B0G105", "DDB_G0282115", "Q54SZ4", "DDB_G0282115", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596" ] }, "reaction_10623304": { "compartment": "compartment_7660", "id": "reaction_10623304", "reactome": "R-DDI-8943040", "name": "HLTF polyubiquitinates monoubiquitinated PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623301", "species_10623270" ], "products": [ "species_10623277", "species_10623264", "species_10623299", "species_10608545" ], "modifiers": [ [ "species_10623301", "catalyst" ] ], "additional_components": [ "Q54T24", "DDB_G0281949", "B0G105", "DDB_G0282115", "Q54SZ4", "DDB_G0282115", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q86K32", "DDB_G0277267", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54D06", "DDB_G0292596", "Q54K47", "DDB_G0287607", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q54T24", "DDB_G0281949", "B0G105", "DDB_G0282115", "Q54SZ4", "DDB_G0282115", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54T24", "DDB_G0281949", "B0G105", "DDB_G0282115", "Q54SZ4", "DDB_G0282115", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596" ] }, "reaction_10623068": { "compartment": "compartment_70101", "id": "reaction_10623068", "reactome": "R-DDI-8938773", "name": "RNF144A polyubiquitinates PRKDC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623060", "species_10623058" ], "products": [ "species_10596492", "species_10623065", "species_10623056" ], "modifiers": [ [ "species_10623060", "catalyst" ] ], "additional_components": [ "Q54TE1", "DDB_G0281833", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54ZG5", "DDB_G0277577", "Q54QC7", "DDB_G0283939", "Q54UC0", "DDB_G0281167", "Q54TE1", "DDB_G0281833", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0281833", "DDB_G0281167", "Q54ZG5", "DDB_G0277577", "Q54QC7", "DDB_G0283939", "Q54TE1", "DDB_G0281833", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54ZG5", "DDB_G0277577", "Q54QC7", "DDB_G0283939", "Q54UC0", "DDB_G0281167" ] }, "reaction_10623916": { "compartment": "compartment_17947", "id": "reaction_10623916", "reactome": "R-DDI-8953946", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623904" ], "products": [ "species_10623913", "species_10577361" ], "modifiers": [ [ "species_10623904", "catalyst" ] ], "additional_components": [ "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54MD1", "DDB_G0286033", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54MD1", "DDB_G0286033", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54MD1", "DDB_G0286033" ] }, "reaction_10619202": { "compartment": "compartment_70101", "id": "reaction_10619202", "reactome": "R-DDI-8853503", "name": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576913" ], "products": [ "species_10579845", "species_10576913" ], "modifiers": [ [ "species_10619199", "catalyst" ] ], "additional_components": [ "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "Q54T48", "DDB_G0282007", "Q869U4", "DDB_G0276443", "Q553T4", "DDB_G0275415" ] }, "reaction_10619233": { "compartment": "compartment_70101", "id": "reaction_10619233", "reactome": "R-DDI-8853515", "name": "OTULIN,USP5 cleaves UBC yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619230" ], "products": [ "species_10577007", "species_10577021", "species_10577035", "species_10576923", "species_10576937", "species_10576951", "species_10576965", "species_10576979", "species_10576993" ], "modifiers": [ [ "species_10610786", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG81", "DDB_G0279721", "P0CG80", "DDB_G0291928", "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "DDB_G0291239" ] }, "reaction_10619237": { "compartment": "compartment_70101", "id": "reaction_10619237", "reactome": "R-DDI-8853529", "name": "OTULIN,USP5 cleaves UBB yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619235" ], "products": [ "species_10576919", "species_10576917", "species_10576915" ], "modifiers": [ [ "species_10610786", "catalyst" ] ], "additional_components": [ "DDB_G0276765", "DDB_G0276765", "DDB_G0276765", "DDB_G0276765", "DDB_G0291239" ] }, "reaction_10619151": { "compartment": "compartment_7660", "id": "reaction_10619151", "reactome": "R-DDI-8852130", "name": "UBA1 conjugates ubiquitin to nuclear E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619115", "species_10619098" ], "products": [ "species_10619149", "species_10619064" ], "modifiers": [], "additional_components": [ "Q54TE1", "DDB_G0281833", "Q54XS6", "DDB_G0278775", "Q54I43", "DDB_G0289021", "Q54F00", "DDB_G0291199", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q55EY8", "DDB_G0268938", "Q553F3", "DDB_G0275787", "Q54VG3", "DDB_G0280347", "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG81", "DDB_G0279721", "P0CG80", "DDB_G0291928", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54I43", "DDB_G0289021", "Q553F3", "DDB_G0275787", "Q54TE1", "DDB_G0281833", "Q54F00", "DDB_G0291199", "Q54J12", "DDB_G0288697", "Q54IK3", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q55EY8", "DDB_G0268938", "Q54VG3", "DDB_G0280347", "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG81", "DDB_G0279721", "P0CG80", "DDB_G0291928", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272" ] }, "reaction_10618924": { "compartment": "compartment_70101", "id": "reaction_10618924", "reactome": "R-DDI-8852127", "name": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618888", "species_10618890" ], "products": [ "species_10618892", "species_10618922" ], "modifiers": [], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG81", "DDB_G0279721", "P14797", "DDB_G0276765", "Q550P6", "DDB_G0277047", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q555G0", "DDB_G0274897", "Q54TE1", "DDB_G0281833", "Q54VG3", "DDB_G0280347", "Q54I43", "DDB_G0289021", "P0CG76", "DDB_G0282295", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG81", "DDB_G0279721", "P14797", "DDB_G0276765", "Q550P6", "DDB_G0277047", "Q54I43", "DDB_G0289021", "Q54TE1", "DDB_G0281833", "Q555G0", "DDB_G0274897", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "Q54VG3", "DDB_G0280347", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765" ] }, "reaction_10619216": { "compartment": "compartment_70101", "id": "reaction_10619216", "reactome": "R-DDI-8853514", "name": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619214" ], "products": [ "species_10580280", "species_10576913" ], "modifiers": [ [ "species_10619199", "catalyst" ] ], "additional_components": [ "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG81", "DDB_G0279721", "P0CG80", "DDB_G0291928", "P0CG88", "DDB_G0269458", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "Q54T48", "DDB_G0282007", "Q869U4", "DDB_G0276443", "Q553T4", "DDB_G0275415" ] }, "reaction_10619153": { "compartment": "compartment_7660", "id": "reaction_10619153", "reactome": "R-DDI-8852131", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10619096", "species_10576865" ], "products": [ "species_10619098", "species_113541" ], "modifiers": [], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG81", "DDB_G0279721", "P0CG80", "DDB_G0291928", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272" ] }, "reaction_10619094": { "compartment": "compartment_70101", "id": "reaction_10619094", "reactome": "R-DDI-8852129", "name": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619068", "species_10619072" ], "products": [ "species_10619092", "species_10619074" ], "modifiers": [], "additional_components": [ "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54XS6", "DDB_G0278775", "Q54VW9", "DDB_G0280091", "Q54VG3", "DDB_G0280347", "Q75JE1", "DDB_G0271726", "Q54TE1", "DDB_G0281833", "Q54I43", "DDB_G0289021", "P0CG76", "DDB_G0282295", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG81", "DDB_G0279721", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272", "Q54I43", "DDB_G0289021", "Q54TE1", "DDB_G0281833", "Q54VG3", "DDB_G0280347", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "Q75JE1", "DDB_G0271726", "Q54XS6", "DDB_G0278775", "Q54VW9", "DDB_G0280091", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG81", "DDB_G0279721", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272" ] }, "reaction_10619159": { "compartment": "compartment_70101", "id": "reaction_10619159", "reactome": "R-DDI-8852133", "name": "UBA1 conjugates ubiquitin to UBA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619074" ], "products": [ "species_10619070", "species_76577" ], "modifiers": [ [ "species_10619074", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG81", "DDB_G0279721", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272", "Q55C16", "DDB_G0270272", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG81", "DDB_G0279721", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272" ] }, "reaction_10619156": { "compartment": "compartment_70101", "id": "reaction_10619156", "reactome": "R-DDI-8852132", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619070", "species_10577037", "species_113592" ], "products": [ "species_111294", "species_10619072" ], "modifiers": [ [ "species_10619070", "catalyst" ] ], "additional_components": [ "Q55C16", "DDB_G0270272", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG81", "DDB_G0279721", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272", "Q55C16", "DDB_G0270272", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765" ] }, "reaction_10619162": { "compartment": "compartment_70101", "id": "reaction_10619162", "reactome": "R-DDI-8852134", "name": "UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_113592", "species_10596583" ], "products": [ "species_111294", "species_10619074" ], "modifiers": [ [ "species_10596583", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0270272", "P0CG76", "DDB_G0282295", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG81", "DDB_G0279721", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272", "DDB_G0270272" ] }, "reaction_10619066": { "compartment": "compartment_7660", "id": "reaction_10619066", "reactome": "R-DDI-8852128", "name": "UBA1 adenylates ubiquitin in the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10618926", "species_10576865" ], "products": [ "species_10619064", "species_113541" ], "modifiers": [], "additional_components": [ "DDB_G0270272", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG81", "DDB_G0279721", "P0CG80", "DDB_G0291928", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272" ] }, "reaction_10619164": { "compartment": "compartment_7660", "id": "reaction_10619164", "reactome": "R-DDI-8852136", "name": "UBA1 conjugates ubiquitin to UBA1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619064" ], "products": [ "species_164121", "species_10619096" ], "modifiers": [], "additional_components": [ "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG81", "DDB_G0279721", "P0CG80", "DDB_G0291928", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272" ] }, "reaction_10594387": { "compartment": "compartment_17963", "id": "reaction_10594387", "reactome": "R-DDI-914005", "name": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10594356" ], "products": [ "species_205687", "species_10594385" ], "modifiers": [], "additional_components": [ "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357", "Q54ZU4", "DDB_G0277357", "Q54KS2", "DDB_G0287193" ] }, "reaction_10594407": { "compartment": "compartment_17963", "id": "reaction_10594407", "reactome": "R-DDI-914008", "name": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10594356" ], "products": [ "species_205687", "species_10594405" ], "modifiers": [], "additional_components": [ "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357", "Q54ZU4", "DDB_G0277357", "Q54KS2", "DDB_G0287193" ] }, "reaction_10594441": { "compartment": "compartment_17963", "id": "reaction_10594441", "reactome": "R-DDI-914017", "name": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10594356" ], "products": [ "species_10594439", "species_205687" ], "modifiers": [], "additional_components": [ "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357", "Q54ZU4", "DDB_G0277357", "Q54KS2", "DDB_G0287193" ] }, "reaction_10594397": { "compartment": "compartment_17963", "id": "reaction_10594397", "reactome": "R-DDI-914006", "name": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10594356" ], "products": [ "species_10594395", "species_205687" ], "modifiers": [], "additional_components": [ "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357", "Q54ZU4", "DDB_G0277357", "Q54KS2", "DDB_G0287193" ] }, "reaction_10603666": { "compartment": "compartment_12045", "id": "reaction_10603666", "reactome": "R-DDI-4419978", "name": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362", "species_4419987" ], "products": [ "species_4419982" ], "modifiers": [ [ "species_10603663", "catalyst" ] ], "additional_components": [ "Q54EN3", "DDB_G0291436", "Q55AK1", "DDB_G0271830" ] }, "reaction_10603674": { "compartment": "compartment_12045", "id": "reaction_10603674", "reactome": "R-DDI-4419979", "name": "SRD5A3 reduces pPNOL to DCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_4419981", "species_29364" ], "products": [ "species_29366", "species_449221" ], "modifiers": [ [ "species_10603671", "catalyst" ] ], "additional_components": [ "DDB_G0284423" ] }, "reaction_10592733": { "compartment": "compartment_12045", "id": "reaction_10592733", "reactome": "R-DDI-446195", "name": "DOLK phosphorylates DCHOL to DOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_449221" ], "products": [ "species_110094", "species_449299" ], "modifiers": [ [ "species_10592730", "catalyst" ] ], "additional_components": [ "DDB_G0285689" ] }, "reaction_10592749": { "compartment": "compartment_12045", "id": "reaction_10592749", "reactome": "R-DDI-446200", "name": "DOLPP1 dephosphorylates DOLDP to DOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_449744" ], "products": [ "species_29372", "species_449299" ], "modifiers": [ [ "species_10592746", "catalyst" ] ], "additional_components": [ "DDB_G0274591" ] }, "reaction_10592768": { "compartment": "compartment_70101", "id": "reaction_10592768", "reactome": "R-DDI-446201", "name": "PMM1,2 isomerise Man6P to Man1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_532562" ], "products": [ "species_532531" ], "modifiers": [ [ "species_10592765", "catalyst" ] ], "additional_components": [ "Q54X03", "DDB_G0279289", "Q86B09", "DDB_G0272781" ] }, "reaction_10593934": { "compartment": "compartment_70101", "id": "reaction_10593934", "reactome": "R-DDI-532549", "name": "MPI isomerises Fru6P to Man6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512" ], "products": [ "species_532562" ], "modifiers": [ [ "species_10593931", "catalyst" ] ], "additional_components": [ "DDB_G0284685" ] }, "reaction_10592802": { "compartment": "compartment_12045", "id": "reaction_10592802", "reactome": "R-DDI-446214", "name": "Synthesis of dolichyl-phosphate-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449299", "species_29410" ], "products": [ "species_532214", "species_110096" ], "modifiers": [ [ "species_10592799", "catalyst" ] ], "additional_components": [ "DDB_G0288321" ] }, "reaction_10591655": { "compartment": "compartment_17938", "id": "reaction_10591655", "reactome": "R-DDI-428585", "name": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428040", "species_428639" ], "products": [ "species_428633", "species_70106" ], "modifiers": [ [ "species_10591652", "catalyst" ] ], "additional_components": [ "DDB_G0280761" ] }, "reaction_10612709": { "compartment": "compartment_70101", "id": "reaction_10612709", "reactome": "R-DDI-6787540", "name": "FUK phosphorylates beta-Fuc to Fuc1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6787678" ], "products": [ "species_29370", "species_6787542" ], "modifiers": [ [ "species_10612706", "catalyst" ] ], "additional_components": [ "DDB_G0269678" ] }, "reaction_10612727": { "compartment": "compartment_70101", "id": "reaction_10612727", "reactome": "R-DDI-6787632", "name": "GMDS dehydrates GDP-Man to GDP-DHDMan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860" ], "products": [ "species_29356", "species_6787618" ], "modifiers": [ [ "species_10612724", "catalyst" ] ], "additional_components": [ "DDB_G0284553" ] }, "reaction_10594121": { "compartment": "compartment_20699", "id": "reaction_10594121", "reactome": "R-DDI-742345", "name": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742368" ], "products": [ "species_205683" ], "modifiers": [ [ "species_10594118", "catalyst" ] ], "additional_components": [ "DDB_G0277007" ] }, "reaction_10612730": { "compartment": "compartment_70101", "id": "reaction_10612730", "reactome": "R-DDI-6787642", "name": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_6787646", "species_29364" ], "products": [ "species_742368", "species_29366" ], "modifiers": [ [ "species_10612716", "catalyst" ] ], "additional_components": [ "Q55C77", "DDB_G0270184" ] }, "reaction_10612701": { "compartment": "compartment_70101", "id": "reaction_10612701", "reactome": "R-DDI-6787533", "name": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_6787542" ], "products": [ "species_111294", "species_742368" ], "modifiers": [ [ "species_10612698", "catalyst" ] ], "additional_components": [ "DDB_G0285257" ] }, "reaction_10612719": { "compartment": "compartment_70101", "id": "reaction_10612719", "reactome": "R-DDI-6787623", "name": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787618" ], "products": [ "species_6787646" ], "modifiers": [ [ "species_10612716", "catalyst" ] ], "additional_components": [ "Q55C77", "DDB_G0270184" ] }, "reaction_10592786": { "compartment": "compartment_70101", "id": "reaction_10592786", "reactome": "R-DDI-446204", "name": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29494", "species_532204" ], "products": [ "species_111294", "species_162756" ], "modifiers": [ [ "species_10592783", "catalyst" ] ], "additional_components": [ "Q54GN5", "DDB_G0290055" ] }, "reaction_10593001": { "compartment": "compartment_70101", "id": "reaction_10593001", "reactome": "R-DDI-449734", "name": "Acetylation of glucosamine 6-phosphate to GlcNAc6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183", "species_449701" ], "products": [ "species_76194", "species_449703" ], "modifiers": [ [ "species_10592998", "catalyst" ] ], "additional_components": [ "Q54WR8", "DDB_G0279475" ] }, "reaction_10592991": { "compartment": "compartment_70101", "id": "reaction_10592991", "reactome": "R-DDI-449715", "name": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512", "species_29472" ], "products": [ "species_29404", "species_449701" ], "modifiers": [ [ "species_10592988", "catalyst" ] ], "additional_components": [ "Q54LK1", "DDB_G0286603" ] }, "reaction_10592725": { "compartment": "compartment_12045", "id": "reaction_10592725", "reactome": "R-DDI-446191", "name": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162756", "species_449299" ], "products": [ "species_109402", "species_449222" ], "modifiers": [ [ "species_10592722", "catalyst" ] ], "additional_components": [ "DDB_G0290751" ] }, "reaction_10592741": { "compartment": "compartment_17957", "id": "reaction_10592741", "reactome": "R-DDI-446198", "name": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449312" ], "products": [ "species_449311", "species_449365" ], "modifiers": [ [ "species_10592738", "catalyst" ], [ "species_10592706", "catalyst" ] ], "additional_components": [ "DDB_G0267884", "DDB_G0295677" ] }, "reaction_10592820": { "compartment": "compartment_12045", "id": "reaction_10592820", "reactome": "R-DDI-446218", "name": "Addition of the first mannose to the N-glycan precursor by ALG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449293" ], "products": [ "species_29420", "species_449283" ], "modifiers": [ [ "species_10592817", "catalyst" ] ], "additional_components": [ "DDB_G0286011" ] }, "reaction_10592708": { "compartment": "compartment_17957", "id": "reaction_10592708", "reactome": "R-DDI-446188", "name": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449298" ], "products": [ "species_449311", "species_449315" ], "modifiers": [ [ "species_10592700", "catalyst" ], [ "species_10592706", "catalyst" ] ], "additional_components": [ "DDB_G0268238", "DDB_G0295677" ] }, "reaction_10592776": { "compartment": "compartment_17957", "id": "reaction_10592776", "reactome": "R-DDI-446202", "name": "Addition of the first glucose to the N-glycan precursor by ALG6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449371", "species_532542" ], "products": [ "species_449311", "species_449649" ], "modifiers": [ [ "species_10592773", "catalyst" ] ], "additional_components": [ "DDB_G0283841" ] }, "reaction_10592794": { "compartment": "compartment_12045", "id": "reaction_10592794", "reactome": "R-DDI-446208", "name": "Addition of a second mannose to the N-glycan precursor by ALG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449283" ], "products": [ "species_449737", "species_29420" ], "modifiers": [ [ "species_10592791", "catalyst" ] ], "additional_components": [ "DDB_G0272730" ] }, "reaction_10592810": { "compartment": "compartment_17957", "id": "reaction_10592810", "reactome": "R-DDI-446215", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449315" ], "products": [ "species_449311", "species_449312" ], "modifiers": [ [ "species_10592807", "catalyst" ], [ "species_10592706", "catalyst" ] ], "additional_components": [ "DDB_G0279349", "DDB_G0295677" ] }, "reaction_10592717": { "compartment": "compartment_17957", "id": "reaction_10592717", "reactome": "R-DDI-446189", "name": "Addition of a second glucose to the N-glycan precursor by ALG8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449649", "species_532542" ], "products": [ "species_449311", "species_449638" ], "modifiers": [ [ "species_10592714", "catalyst" ] ], "additional_components": [ "DDB_G0275261" ] }, "reaction_10592812": { "compartment": "compartment_17957", "id": "reaction_10592812", "reactome": "R-DDI-446216", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449365" ], "products": [ "species_449371", "species_449311" ], "modifiers": [ [ "species_10592807", "catalyst" ], [ "species_10592706", "catalyst" ] ], "additional_components": [ "DDB_G0279349", "DDB_G0295677" ] }, "reaction_10619185": { "compartment": "compartment_70101", "id": "reaction_10619185", "reactome": "R-DDI-8853379", "name": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10596971" ], "products": [ "species_8853371", "species_8853381" ], "modifiers": [ [ "species_10619182", "catalyst" ] ], "additional_components": [ "CHEBI:60627", "CHEBI:60628", "species_915149", "CHEBI:60629", "species_964740", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "species_8853396", "species_6799540", "CHEBI:91283", "CHEBI:91282", "CHEBI:91281", "DDB_G0268520" ] }, "reaction_10596973": { "compartment": "compartment_70101", "id": "reaction_10596973", "reactome": "R-DDI-1022127", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596969" ], "products": [ "species_10596971" ], "modifiers": [], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "CHEBI:60627", "CHEBI:60628", "species_915149", "CHEBI:60629", "species_964740", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765" ] }, "reaction_10594300": { "compartment": "compartment_17957", "id": "reaction_10594300", "reactome": "R-DDI-901047", "name": "Binding of ERp57", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594296", "species_10594000" ], "products": [ "species_10594298" ], "modifiers": [], "additional_components": [ "CHEBI:59080", "Q55BA8", "DDB_G0271144", "Q23858", "DDB_G0283539", "DDB_G0291434", "Q54EN4", "DDB_G0291434", "CHEBI:59080", "Q55BA8", "DDB_G0271144", "Q23858", "DDB_G0283539" ] }, "reaction_10595778": { "compartment": "compartment_20699", "id": "reaction_10595778", "reactome": "R-DDI-975814", "name": "Trimming of mannoses on the alpha1,6 arm by MAN2A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964837" ], "products": [ "species_964752", "species_975819" ], "modifiers": [ [ "species_10595775", "catalyst" ] ], "additional_components": [ "Q54KN4", "DDB_G0287231", "species_29426" ] }, "reaction_10596981": { "compartment": "compartment_20699", "id": "reaction_10596981", "reactome": "R-DDI-1028788", "name": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975910", "species_205683" ], "products": [ "species_205689", "species_1028779" ], "modifiers": [ [ "species_10596978", "catalyst" ] ], "additional_components": [ "DDB_G0278473" ] }, "reaction_10611509": { "compartment": "compartment_17963", "id": "reaction_10611509", "reactome": "R-DDI-5693925", "name": "FUT3 transfers L-fucose to Gal1,3GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693930", "species_205683" ], "products": [ "species_5693933", "species_205689" ], "modifiers": [ [ "species_10611506", "catalyst" ] ], "additional_components": [ "Q54PK0", "DDB_G0284775", "Q86J24", "DDB_G0284775", "Q54P60", "DDB_G0284775", "Q54PH9", "DDB_G0284467", "Q54PK3", "DDB_G0284551", "Q54RA6", "DDB_G0284775", "Q54PJ9", "DDB_G0284775" ] }, "reaction_10611469": { "compartment": "compartment_161320", "id": "reaction_10611469", "reactome": "R-DDI-5693807", "name": "FUCA1 hydrolyses NGP:1,6-GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_6784247" ], "products": [ "species_6784248", "species_6784249" ], "modifiers": [ [ "species_10611466", "catalyst" ] ], "additional_components": [ "P10901", "DDB_G0274391", "Q551C1", "DDB_G0276661" ] }, "reaction_10595786": { "compartment": "compartment_17963", "id": "reaction_10595786", "reactome": "R-DDI-975926", "name": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_975910" ], "products": [ "species_981613" ], "modifiers": [ [ "species_10595783", "catalyst" ] ], "additional_components": [ "DDB_G0272422" ] }, "reaction_10620710": { "compartment": "compartment_70101", "id": "reaction_10620710", "reactome": "R-DDI-8870457", "name": "FarC-PTP4A2 binds RABGGTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620704", "species_10620706" ], "products": [ "species_10620708" ], "modifiers": [], "additional_components": [ "Q54DU9", "DDB_G0292024", "Q86IL4", "DDB_G0292024", "DDB_G0290671", "B0G172", "DDB_G0290671", "Q54DU9", "DDB_G0292024", "Q86IL4", "DDB_G0292024" ] }, "reaction_10620725": { "compartment": "compartment_70101", "id": "reaction_10620725", "reactome": "R-DDI-8870465", "name": "RGGT binds the RAB-binding subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1131164", "species_10620714", "species_10620721" ], "products": [ "species_10620723" ], "modifiers": [], "additional_components": [ "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "Q54VT9", "DDB_G0280143", "Q54VT9", "DDB_G0280143", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "species_1131164" ] }, "reaction_10621957": { "compartment": "compartment_70101", "id": "reaction_10621957", "reactome": "R-DDI-8870469", "name": "RGGT geranylgeranylates RAB proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1131164", "species_10621130" ], "products": [ "species_1132084", "species_10621952", "species_10621954" ], "modifiers": [ [ "species_10621130", "catalyst" ] ], "additional_components": [ "Q54VT9", "DDB_G0280143", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "species_1131164", "Q86JP3", "DDB_G0271984", "Q54RY4", "DDB_G0282899", "P20790", "DDB_G0280043", "Q1ZXE7", "DDB_G0286169", "P20791", "DDB_G0276399", "P36409", "DDB_G0292268", "Q8MXQ2", "DDB_G0275675", "Q1ZXC0", "DDB_G0290827", "Q54QR3", "DDB_G0283603", "P36412", "DDB_G0269238", "P34139", "DDB_G0283757", "Q86JP0", "DDB_G0294583", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "species_29420", "Q54VT9", "DDB_G0280143", "species_29420", "Q8MXQ2", "DDB_G0275675", "Q1ZXC0", "DDB_G0290827", "Q54QR3", "DDB_G0283603", "P34139", "DDB_G0283757", "P36412", "DDB_G0269238", "P34143", "DDB_G0271736", "Q558I0", "DDB_G0272905", "Q54EW9", "DDB_G0291293", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "Q54NU2", "DDB_G0284985", "P34141", "DDB_G0291233", "Q552K3", "DDB_G0275969", "P36409", "DDB_G0292268", "Q86JP0", "DDB_G0294583", "Q1ZXE7", "DDB_G0286169", "P20791", "DDB_G0276399", "Q54RY4", "DDB_G0282899", "P20790", "DDB_G0280043", "Q86JP3", "DDB_G0271984", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "species_1131164", "Q54VT9", "DDB_G0280143", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "species_1131164", "Q86JP3", "DDB_G0271984", "Q54RY4", "DDB_G0282899", "P20790", "DDB_G0280043", "Q1ZXE7", "DDB_G0286169", "P20791", "DDB_G0276399", "P36409", "DDB_G0292268", "Q8MXQ2", "DDB_G0275675", "Q1ZXC0", "DDB_G0290827", "Q54QR3", "DDB_G0283603", "P36412", "DDB_G0269238", "P34139", "DDB_G0283757", "Q86JP0", "DDB_G0294583", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "species_29420" ] }, "reaction_10620716": { "compartment": "compartment_70101", "id": "reaction_10620716", "reactome": "R-DDI-8870461", "name": "RABGGTA and RABGGTB bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620712", "species_10620706" ], "products": [ "species_10620714" ], "modifiers": [ [ "species_10620708", "inhibitor" ] ], "additional_components": [ "DDB_G0269570", "DDB_G0290671", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "B0G172", "DDB_G0290671", "Q54DU9", "DDB_G0292024", "Q86IL4", "DDB_G0292024" ] }, "reaction_10621132": { "compartment": "compartment_70101", "id": "reaction_10621132", "reactome": "R-DDI-8870466", "name": "RGGT:CHM binds RABs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10621128", "species_10620723" ], "products": [ "species_10621130" ], "modifiers": [], "additional_components": [ "Q86JP3", "DDB_G0271984", "Q54RY4", "DDB_G0282899", "P20790", "DDB_G0280043", "Q1ZXE7", "DDB_G0286169", "P20791", "DDB_G0276399", "P36409", "DDB_G0292268", "Q8MXQ2", "DDB_G0275675", "Q1ZXC0", "DDB_G0290827", "Q54QR3", "DDB_G0283603", "P36412", "DDB_G0269238", "P34139", "DDB_G0283757", "Q86JP0", "DDB_G0294583", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "species_29420", "Q54VT9", "DDB_G0280143", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "species_1131164", "Q54VT9", "DDB_G0280143", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "species_1131164", "Q86JP3", "DDB_G0271984", "Q54RY4", "DDB_G0282899", "P20790", "DDB_G0280043", "Q1ZXE7", "DDB_G0286169", "P20791", "DDB_G0276399", "P36409", "DDB_G0292268", "Q8MXQ2", "DDB_G0275675", "Q1ZXC0", "DDB_G0290827", "Q54QR3", "DDB_G0283603", "P36412", "DDB_G0269238", "P34139", "DDB_G0283757", "Q86JP0", "DDB_G0294583", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "species_29420" ] }, "reaction_10583985": { "compartment": "compartment_70101", "id": "reaction_10583985", "reactome": "R-DDI-162857", "name": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855657", "species_29356" ], "products": [ "species_8855661", "species_29416" ], "modifiers": [ [ "species_10583982", "catalyst" ] ], "additional_components": [ "DDB_G0293136" ] }, "reaction_10583923": { "compartment": "compartment_70101", "id": "reaction_10583923", "reactome": "R-DDI-162730", "name": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426639", "species_162756" ], "products": [ "species_8855657", "species_110096" ], "modifiers": [ [ "species_10583920", "catalyst" ] ], "additional_components": [ "Q86K35", "DDB_G0277289", "Q86JM6", "DDB_G0272006", "Q556K9", "DDB_G0272588", "Q54QB2", "DDB_G0283965", "Q54M40", "DDB_G0286221", "Q54WP5", "DDB_G0279515" ] }, "reaction_10583954": { "compartment": "compartment_12045", "id": "reaction_10583954", "reactome": "R-DDI-162798", "name": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855659", "species_1500581" ], "products": [ "species_8855663", "species_1500596" ], "modifiers": [ [ "species_10583951", "catalyst" ] ], "additional_components": [ "DDB_G0279313" ] }, "reaction_10583938": { "compartment": "compartment_12045", "id": "reaction_10583938", "reactome": "R-DDI-162742", "name": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855660" ], "products": [ "species_8855660" ], "modifiers": [ [ "species_10583935", "catalyst" ] ], "additional_components": [ "Q54PB0", "DDB_G0284667", "Q551Y7", "DDB_G0276251" ] }, "reaction_10583977": { "compartment": "compartment_12045", "id": "reaction_10583977", "reactome": "R-DDI-162830", "name": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_8855665" ], "products": [ "species_8855659", "species_162872" ], "modifiers": [ [ "species_10583974", "catalyst" ] ], "additional_components": [ "Q54QP2", "DDB_G0283717", "Q54IA4", "DDB_G0288899" ] }, "reaction_10583993": { "compartment": "compartment_12045", "id": "reaction_10583993", "reactome": "R-DDI-162873", "name": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_8855663" ], "products": [ "species_162872", "species_8855667" ], "modifiers": [ [ "species_10583990", "catalyst" ] ], "additional_components": [ "DDB_G0280891" ] }, "reaction_10583962": { "compartment": "compartment_12045", "id": "reaction_10583962", "reactome": "R-DDI-162821", "name": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_8855667" ], "products": [ "species_8855656", "species_162872" ], "modifiers": [ [ "species_10583959", "catalyst" ] ], "additional_components": [ "DDB_G0284435" ] }, "reaction_10583946": { "compartment": "compartment_12045", "id": "reaction_10583946", "reactome": "R-DDI-162797", "name": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855656", "species_449229" ], "products": [ "species_8855664" ], "modifiers": [ [ "species_10583943", "catalyst" ] ], "additional_components": [ "DDB_G0291660" ] }, "reaction_10583871": { "compartment": "compartment_17957", "id": "reaction_10583871", "reactome": "R-DDI-162683", "name": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_8855661" ], "products": [ "species_8855666", "species_76194" ], "modifiers": [ [ "species_10583868", "catalyst" ] ], "additional_components": [ "DDB_G0286111" ] }, "reaction_10623183": { "compartment": "compartment_984", "id": "reaction_10623183", "reactome": "R-DDI-8940388", "name": "GPLD1 hydrolyses GPI-anchors from proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10623153" ], "products": [ "species_10623175", "species_2197633" ], "modifiers": [ [ "species_10623180", "catalyst" ] ], "additional_components": [ "Q55E77", "DDB_G0270488", "Q54WG1", "DDB_G0279675", "Q54I77", "DDB_G0288963", "Q54G06", "DDB_G0290501", "Q54WG1", "DDB_G0279675", "Q55E77", "DDB_G0270488", "Q54I77", "DDB_G0288963", "Q54G06", "DDB_G0290501", "DDB_G0276919" ] }, "reaction_10605201": { "compartment": "compartment_70101", "id": "reaction_10605201", "reactome": "R-DDI-5358475", "name": "DPH6 ligates ammonium to diphthine-EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10605193", "species_31633" ], "products": [ "species_111294", "species_10583767", "species_76577" ], "modifiers": [ [ "species_10605198", "catalyst" ] ], "additional_components": [ "DDB_G0288373", "DDB_G0288373", "DDB_G0278373" ] }, "reaction_10605237": { "compartment": "compartment_70101", "id": "reaction_10605237", "reactome": "R-DDI-5358494", "name": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10605217" ], "products": [ "species_353106", "species_10605204" ], "modifiers": [ [ "species_10605234", "catalyst" ] ], "additional_components": [ "DDB_G0288373", "DDB_G0288373", "Q7KWL8", "DDB_G0277061", "Q54PW5", "DDB_G0284257", "B0G132", "DDB_G0295687" ] }, "reaction_10605215": { "compartment": "compartment_70101", "id": "reaction_10605215", "reactome": "R-DDI-5358484", "name": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10605204" ], "products": [ "species_10605207", "species_71285" ], "modifiers": [ [ "species_10605212", "catalyst" ] ], "additional_components": [ "DDB_G0288373", "DDB_G0288373", "DDB_G0276115" ] }, "reaction_10612822": { "compartment": "compartment_12045", "id": "reaction_10612822", "reactome": "R-DDI-6788650", "name": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788753", "species_71284" ], "products": [ "species_71285", "species_6788758" ], "modifiers": [ [ "species_10612819", "catalyst" ] ], "additional_components": [ "Q558K8", "DDB_G0272799", "species_29426" ] }, "reaction_10588135": { "compartment": "compartment_70101", "id": "reaction_10588135", "reactome": "R-DDI-204662", "name": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_10588102", "species_73473" ], "products": [ "species_29356", "species_10588123", "species_29360" ], "modifiers": [ [ "species_10588132", "catalyst" ] ], "additional_components": [ "DDB_G0284861", "DDB_G0284861", "Q556G4", "DDB_G0272634", "species_71067" ] }, "reaction_10588118": { "compartment": "compartment_70101", "id": "reaction_10588118", "reactome": "R-DDI-204617", "name": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_204628", "species_10588102", "species_73473" ], "products": [ "species_10588106", "species_204635", "species_29360" ], "modifiers": [ [ "species_10588115", "catalyst" ] ], "additional_components": [ "DDB_G0284861", "DDB_G0284861", "Q54MQ7", "DDB_G0285725" ] }, "reaction_10621975": { "compartment": "compartment_70101", "id": "reaction_10621975", "reactome": "R-DDI-8873946", "name": "OTUD3 deubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10621972" ], "products": [ "species_10587224" ], "modifiers": [ [ "species_10616721", "catalyst" ] ], "additional_components": [ "DDB_G0286557", "DDB_G0286557", "DDB_G0267906" ] }, "reaction_10612360": { "compartment": "compartment_70101", "id": "reaction_10612360", "reactome": "R-DDI-6781953", "name": "YOD1 binds VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605038", "species_10612356" ], "products": [ "species_10612358" ], "modifiers": [], "additional_components": [ "DDB_G0288065", "DDB_G0271346", "Q55BI3", "DDB_G0271346", "P90532", "DDB_G0288065" ] }, "reaction_10611237": { "compartment": "compartment_7660", "id": "reaction_10611237", "reactome": "R-DDI-5691381", "name": "MYSM1 deubiquitinates Histone H2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10611232" ], "products": [ "species_10611234", "species_10576865" ], "modifiers": [ [ "species_10611232", "catalyst" ] ], "additional_components": [ "Q54R05", "DDB_G0283459", "Q54J55", "DDB_G0288285", "Q550R6", "DDB_G0277033", "Q54R05", "DDB_G0283459", "Q54J55", "DDB_G0288285", "Q550R6", "DDB_G0277033", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R05", "DDB_G0283459", "Q54J55", "DDB_G0288285", "Q550R6", "DDB_G0277033" ] }, "reaction_10611958": { "compartment": "compartment_70101", "id": "reaction_10611958", "reactome": "R-DDI-5696547", "name": "STAMBPL1 is a deubiquitinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584754" ], "products": [ "species_10584752" ], "modifiers": [ [ "species_10611955", "catalyst" ] ], "additional_components": [ "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "DDB_G0284037" ] }, "reaction_10611240": { "compartment": "compartment_70101", "id": "reaction_10611240", "reactome": "R-DDI-5691431", "name": "PSMD14 cleaves K63-linked ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584754" ], "products": [ "species_10584752" ], "modifiers": [ [ "species_10577042", "catalyst" ] ], "additional_components": [ "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "DDB_G0272566" ] }, "reaction_10612001": { "compartment": "compartment_70101", "id": "reaction_10612001", "reactome": "R-DDI-5696600", "name": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10611992" ], "products": [ "species_10611998", "species_10609754" ], "modifiers": [ [ "species_10611992", "catalyst" ] ], "additional_components": [ "Q54QM6", "DDB_G0283617", "Q86L44", "DDB_G0294407", "Q86J16", "DDB_G0274827", "Q86J16", "DDB_G0274827", "Q86L44", "DDB_G0294407", "Q54QM6", "DDB_G0283617", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54QM6", "DDB_G0283617", "Q86L44", "DDB_G0294407", "Q86J16", "DDB_G0274827" ] }, "reaction_10610823": { "compartment": "compartment_7660", "id": "reaction_10610823", "reactome": "R-DDI-5690157", "name": "USP16,USP21 deubiquitinate Histone H2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10610818" ], "products": [ "species_10610820", "species_10576865" ], "modifiers": [ [ "species_10610818", "catalyst" ] ], "additional_components": [ "Q55EJ1", "DDB_G0268872", "Q86KB3", "DDB_G0274207", "Q55EJ1", "DDB_G0268872", "Q86KB3", "DDB_G0274207", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55EJ1", "DDB_G0268872", "Q86KB3", "DDB_G0274207" ] }, "reaction_10609766": { "compartment": "compartment_70101", "id": "reaction_10609766", "reactome": "R-DDI-5689539", "name": "ADRM1:26S proteaseome binds USP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606645", "species_10609762" ], "products": [ "species_10609764" ], "modifiers": [], "additional_components": [ "Q556N5", "DDB_G0272624", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408", "DDB_G0271264", "Q55BC4", "DDB_G0271264", "Q556N5", "DDB_G0272624", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10610793": { "compartment": "compartment_70101", "id": "reaction_10610793", "reactome": "R-DDI-5690152", "name": "USP5 cleaves polyubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10610788" ], "products": [ "species_10577037", "species_10610790" ], "modifiers": [ [ "species_10610788", "catalyst" ] ], "additional_components": [ "P54201", "DDB_G0291239", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P54201", "DDB_G0291239", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P54201", "DDB_G0291239", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295" ] }, "reaction_10612299": { "compartment": "compartment_70101", "id": "reaction_10612299", "reactome": "R-DDI-6781814", "name": "USP19 deubiquitinates RNF123", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10612294" ], "products": [ "species_10612296", "species_10584754" ], "modifiers": [ [ "species_10612294", "catalyst" ] ], "additional_components": [ "B0G199", "DDB_G0293770", "Q54PQ7", "DDB_G0293770", "Q54N05", "DDB_G0285581", "B0G199", "DDB_G0293770", "Q54PQ7", "DDB_G0293770", "Q54N05", "DDB_G0285581", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "B0G199", "DDB_G0293770", "Q54PQ7", "DDB_G0293770", "Q54N05", "DDB_G0285581" ] }, "reaction_10611978": { "compartment": "compartment_70101", "id": "reaction_10611978", "reactome": "R-DDI-5696564", "name": "USP25 deubiquitinates DDX58", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611966", "species_29356" ], "products": [ "species_10609754", "species_10611968" ], "modifiers": [ [ "species_10611966", "catalyst" ] ], "additional_components": [ "Q54DT4", "DDB_G0292046", "Q553T4", "DDB_G0275415", "Q86L44", "DDB_G0294407", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q86L44", "DDB_G0294407", "Q54DT4", "DDB_G0292046", "Q553T4", "DDB_G0275415", "Q54DT4", "DDB_G0292046", "Q553T4", "DDB_G0275415", "Q86L44", "DDB_G0294407" ] }, "reaction_10612202": { "compartment": "compartment_7660", "id": "reaction_10612202", "reactome": "R-DDI-5696958", "name": "USP44 deubiquitinates CDC20", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10612197" ], "products": [ "species_10610745", "species_10612199" ], "modifiers": [ [ "species_10612197", "catalyst" ] ], "additional_components": [ "Q54MZ3", "DDB_G0285601", "Q55EJ1", "DDB_G0268872", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55EJ1", "DDB_G0268872", "Q54MZ3", "DDB_G0285601", "Q54MZ3", "DDB_G0285601", "Q55EJ1", "DDB_G0268872" ] }, "reaction_10612234": { "compartment": "compartment_7660", "id": "reaction_10612234", "reactome": "R-DDI-5696960", "name": "USP49 deubiquitinates H2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10612229" ], "products": [ "species_10612231", "species_10576865" ], "modifiers": [ [ "species_10612229", "catalyst" ] ], "additional_components": [ "Q55EJ1", "DDB_G0268872", "Q55EJ1", "DDB_G0268872", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55EJ1", "DDB_G0268872" ] }, "reaction_10620654": { "compartment": "compartment_70101", "id": "reaction_10620654", "reactome": "R-DDI-8869456", "name": "USP4 deubiquitinate TRAF2,TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10620649" ], "products": [ "species_10609754", "species_10620651" ], "modifiers": [ [ "species_10611973", "catalyst" ] ], "additional_components": [ "B0G199", "DDB_G0293770", "Q54FB9", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54YP8", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "DDB_G0293770" ] }, "reaction_10612268": { "compartment": "compartment_7660", "id": "reaction_10612268", "reactome": "R-DDI-5697009", "name": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10612261" ], "products": [ "species_10610745", "species_10612265" ], "modifiers": [ [ "species_10612261", "catalyst" ] ], "additional_components": [ "Q54C28", "DDB_G0293226", "P34124", "DDB_G0292382", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54C28", "DDB_G0293226", "P34124", "DDB_G0292382", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "Q54C28", "DDB_G0293226", "P34124", "DDB_G0292382", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493" ] }, "reaction_10612468": { "compartment": "compartment_7660", "id": "reaction_10612468", "reactome": "R-DDI-6782820", "name": "USP17 deubiquitinates SUDS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10612463" ], "products": [ "species_10610329", "species_10612465" ], "modifiers": [ [ "species_10612463", "catalyst" ] ], "additional_components": [ "Q86J16", "DDB_G0274827", "Q54PU3", "DDB_G0284289", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54PU3", "DDB_G0284289", "Q86J16", "DDB_G0274827", "Q86J16", "DDB_G0274827", "Q54PU3", "DDB_G0284289" ] }, "reaction_10612280": { "compartment": "compartment_70101", "id": "reaction_10612280", "reactome": "R-DDI-6781779", "name": "USP13 deubiquitinates BECN1,USP10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10612275" ], "products": [ "species_10612277", "species_10584754" ], "modifiers": [ [ "species_10612275", "catalyst" ] ], "additional_components": [ "Q54JI9", "DDB_G0288021", "P54201", "DDB_G0291239", "Q54JI9", "DDB_G0288021", "P54201", "DDB_G0291239", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54JI9", "DDB_G0288021", "P54201", "DDB_G0291239" ] }, "reaction_10612155": { "compartment": "compartment_70101", "id": "reaction_10612155", "reactome": "R-DDI-5696627", "name": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10612104" ], "products": [ "species_10612152", "species_10584754" ], "modifiers": [ [ "species_10612104", "catalyst" ] ], "additional_components": [ "Q54XX5", "DDB_G0278535", "Q54FC5", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "P11467", "DDB_G0290961", "Q1ZXR0", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54ZW5", "DDB_G0277345", "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54XX5", "DDB_G0278535", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54XX5", "DDB_G0278535", "Q54FC5", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "P11467", "DDB_G0290961", "Q1ZXR0", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54ZW5", "DDB_G0277345" ] }, "reaction_10610842": { "compartment": "compartment_70101", "id": "reaction_10610842", "reactome": "R-DDI-5690159", "name": "USP21 deubiquitinates RIPK1,DDX58", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10610835" ], "products": [ "species_10609754", "species_10610839" ], "modifiers": [ [ "species_10610835", "catalyst" ] ], "additional_components": [ "Q54XX5", "DDB_G0278535", "Q86L44", "DDB_G0294407", "Q55EJ1", "DDB_G0268872", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54XX5", "DDB_G0278535", "Q86L44", "DDB_G0294407", "Q55EJ1", "DDB_G0268872", "Q54XX5", "DDB_G0278535", "Q86L44", "DDB_G0294407", "Q55EJ1", "DDB_G0268872" ] }, "reaction_10612029": { "compartment": "compartment_7660", "id": "reaction_10612029", "reactome": "R-DDI-5696605", "name": "USP12, USP26 deubiquitinate AR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10612022" ], "products": [ "species_10612026", "species_10610745" ], "modifiers": [ [ "species_10612022", "catalyst" ] ], "additional_components": [ "Q54ZP5", "DDB_G0277533", "Q54G37", "DDB_G0290453", "Q54UB2", "DDB_G0281319", "Q54ZP5", "DDB_G0277533", "Q54G37", "DDB_G0290453", "Q54UB2", "DDB_G0281319", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54ZP5", "DDB_G0277533", "Q54G37", "DDB_G0290453", "Q54UB2", "DDB_G0281319" ] }, "reaction_10610748": { "compartment": "compartment_7660", "id": "reaction_10610748", "reactome": "R-DDI-5689950", "name": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10609773" ], "products": [ "species_10610745", "species_10609777" ], "modifiers": [ [ "species_10609773", "catalyst" ] ], "additional_components": [ "Q8T9S7", "DDB_G0286557", "Q869U4", "DDB_G0276443", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q869U4", "DDB_G0276443", "Q8T9S7", "DDB_G0286557", "Q8T9S7", "DDB_G0286557", "Q869U4", "DDB_G0276443" ] }, "reaction_10595007": { "compartment": "compartment_70101", "id": "reaction_10595007", "reactome": "R-DDI-936390", "name": "CYLD mediated deubiquitination of DDX58 (RIG-I)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10595000" ], "products": [ "species_10577037", "species_10595002" ], "modifiers": [ [ "species_10595004", "catalyst" ] ], "additional_components": [ "DDB_G0294407", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0294407", "DDB_G0277345" ] }, "reaction_10609757": { "compartment": "compartment_70101", "id": "reaction_10609757", "reactome": "R-DDI-5689111", "name": "PARK2 autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609754", "species_10596322" ], "products": [ "species_10608777" ], "modifiers": [ [ "species_10596322", "catalyst" ] ], "additional_components": [ "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54I29", "DDB_G0289043", "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043" ] }, "reaction_10608751": { "compartment": "compartment_70101", "id": "reaction_10608751", "reactome": "R-DDI-5688797", "name": "ATXN3 family cleave Ub chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10584754" ], "products": [ "species_10584754", "species_10584752" ], "modifiers": [ [ "species_10608748", "catalyst" ] ], "additional_components": [ "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q55DI9", "DDB_G0269646" ] }, "reaction_10590032": { "compartment": "compartment_12045", "id": "reaction_10590032", "reactome": "R-DDI-381109", "name": "IRE1 binds IRE1 forming dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590020" ], "products": [ "species_10590022" ], "modifiers": [], "additional_components": [ "DDB_G0267650", "Q55GJ2", "DDB_G0267650" ] }, "reaction_10590030": { "compartment": "compartment_12045", "id": "reaction_10590030", "reactome": "R-DDI-381091", "name": "IRE1 dimer autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10590022" ], "products": [ "species_10590027", "species_29370" ], "modifiers": [ [ "species_10590022", "catalyst" ] ], "additional_components": [ "Q55GJ2", "DDB_G0267650", "Q55GJ2", "DDB_G0267650", "Q55GJ2", "DDB_G0267650" ] }, "reaction_10590082": { "compartment": "compartment_12045", "id": "reaction_10590082", "reactome": "R-DDI-381186", "name": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590078" ], "products": [ "species_10590052" ], "modifiers": [], "additional_components": [ "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023" ] }, "reaction_10590886": { "compartment": "compartment_20699", "id": "reaction_10590886", "reactome": "R-DDI-420818", "name": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590058" ], "products": [ "species_10590878", "species_10589991" ], "modifiers": [ [ "species_10590883", "catalyst" ] ], "additional_components": [ "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "DDB_G0275939" ] }, "reaction_10590072": { "compartment": "compartment_20699", "id": "reaction_10590072", "reactome": "R-DDI-381135", "name": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590052" ], "products": [ "species_10590058", "species_10590064" ], "modifiers": [ [ "species_10590069", "catalyst" ] ], "additional_components": [ "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023", "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "DDB_G0282397" ] }, "reaction_10589999": { "compartment": "compartment_70101", "id": "reaction_10589999", "reactome": "R-DDI-381026", "name": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589991" ], "products": [ "species_10589997" ], "modifiers": [], "additional_components": [ "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439" ] }, "reaction_10590040": { "compartment": "compartment_70101", "id": "reaction_10590040", "reactome": "R-DDI-381111", "name": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10580002" ], "products": [ "species_29370", "species_10590037" ], "modifiers": [ [ "species_10590013", "catalyst" ] ], "additional_components": [ "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "Q54R98", "DDB_G0283301" ] }, "reaction_10590015": { "compartment": "compartment_12045", "id": "reaction_10590015", "reactome": "R-DDI-381087", "name": "Dimerization of PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590004" ], "products": [ "species_10590013" ], "modifiers": [], "additional_components": [ "DDB_G0283301", "Q54R98", "DDB_G0283301" ] }, "reaction_10577620": { "compartment": "compartment_7660", "id": "reaction_10577620", "reactome": "R-DDI-69608", "name": "Phosphorylation of Cdc25A at Ser-123 by Chk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10577539" ], "products": [ "species_10577598", "species_113582" ], "modifiers": [ [ "species_10577617", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "DDB_G0280321" ] }, "reaction_10577608": { "compartment": "compartment_7660", "id": "reaction_10577608", "reactome": "R-DDI-69604", "name": "Phosphorylation of Cdc25A at Ser-123 by Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10577539" ], "products": [ "species_10577598", "species_113582" ], "modifiers": [ [ "species_10577605", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "DDB_G0279719" ] }, "reaction_10577596": { "compartment": "compartment_70101", "id": "reaction_10577596", "reactome": "R-DDI-69600", "name": "Proteolytic degradation of ubiquitinated-Cdc25A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577594" ], "products": [ "species_10577037" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q54QM6", "DDB_G0283617", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10626291": { "compartment": "compartment_161320", "id": "reaction_10626291", "reactome": "R-DDI-9638076", "name": "HEXB cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162223", "species_1605715" ], "products": [ "species_1678743", "species_2162224" ], "modifiers": [ [ "species_10598378", "catalyst" ] ], "additional_components": [ "P13723", "DDB_G0287033" ] }, "reaction_10600527": { "compartment": "compartment_161320", "id": "reaction_10600527", "reactome": "R-DDI-2162225", "name": "HEXA cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162223", "species_1605715" ], "products": [ "species_1678743", "species_2162224" ], "modifiers": [ [ "species_10598376", "catalyst" ] ], "additional_components": [ "Q54K55", "DDB_G0287597", "Q54SC9", "DDB_G0282539", "Q54K56", "DDB_G0287659", "Q54MU9", "DDB_G0285647", "P13723", "DDB_G0287033" ] }, "reaction_10612384": { "compartment": "compartment_7660", "id": "reaction_10612384", "reactome": "R-DDI-6782069", "name": "UVSSA:USP7 deubiquitinates ERCC6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10612375" ], "products": [ "species_10612381", "species_10576865" ], "modifiers": [ [ "species_10612375", "catalyst" ] ], "additional_components": [ "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54TY2", "DDB_G0281441", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54TY2", "DDB_G0281441", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54TY2", "DDB_G0281441", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10612308": { "compartment": "compartment_7660", "id": "reaction_10612308", "reactome": "R-DDI-6781824", "name": "Active RNA Pol II complex transcribes lesion-containing DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612301", "species_6781829" ], "products": [ "species_113541", "species_10612305" ], "modifiers": [ [ "species_10612301", "catalyst" ] ], "additional_components": [ "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729" ] }, "reaction_10612328": { "compartment": "compartment_7660", "id": "reaction_10612328", "reactome": "R-DDI-6781833", "name": "ERCC8 (CSA) binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612315", "species_10612324" ], "products": [ "species_10611193", "species_10612326" ], "modifiers": [], "additional_components": [ "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54TY2", "DDB_G0281441", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54PF3", "DDB_G0284597", "Q54QX3", "DDB_G0283587", "Q54HL6", "DDB_G0289361", "Q55BD5", "DDB_G0271282", "Q54E53", "DDB_G0291848", "Q54C92", "DDB_G0293180", "Q75K24", "DDB_G0275471", "Q54B82", "DDB_G0293844", "Q54PF3", "DDB_G0284597", "Q54QX3", "DDB_G0283587", "Q54HL6", "DDB_G0289361", "Q55BD5", "DDB_G0271282", "Q54E53", "DDB_G0291848", "Q54C92", "DDB_G0293180", "Q75K24", "DDB_G0275471", "Q54B82", "DDB_G0293844", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54TY2", "DDB_G0281441" ] }, "reaction_10612330": { "compartment": "compartment_7660", "id": "reaction_10612330", "reactome": "R-DDI-6781840", "name": "ERCC6 binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612313", "species_10612305" ], "products": [ "species_10612315" ], "modifiers": [], "additional_components": [ "DDB_G0281441", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54TY2", "DDB_G0281441" ] }, "reaction_10612349": { "compartment": "compartment_7660", "id": "reaction_10612349", "reactome": "R-DDI-6781867", "name": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612326", "species_10576865" ], "products": [ "species_10612346" ], "modifiers": [ [ "species_10612326", "catalyst" ] ], "additional_components": [ "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54TY2", "DDB_G0281441", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54TY2", "DDB_G0281441", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54TY2", "DDB_G0281441" ] }, "reaction_10612303": { "compartment": "compartment_7660", "id": "reaction_10612303", "reactome": "R-DDI-6781818", "name": "RNA Pol II initiates transcription from damaged DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580699", "species_10578887", "species_5688114" ], "products": [ "species_10612301" ], "modifiers": [], "additional_components": [ "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729" ] }, "reaction_10590490": { "compartment": "compartment_70101", "id": "reaction_10590490", "reactome": "R-DDI-390329", "name": "Dephosphorylation of AKT by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10586959", "species_29356" ], "products": [ "species_29372", "species_10590487" ], "modifiers": [ [ "species_10590274", "catalyst" ] ], "additional_components": [ "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795" ] }, "reaction_10624161": { "compartment": "compartment_984", "id": "reaction_10624161", "reactome": "R-DDI-8979996", "name": "LIPs hydrolyze TG to DAG and LCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10624158", "catalyst" ] ], "additional_components": [] }, "reaction_10591551": { "compartment": "compartment_876", "id": "reaction_10591551", "reactome": "R-DDI-427998", "name": "Proton-coupled di- and tri-peptide cotransport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_428037" ], "products": [ "species_428026", "species_70106" ], "modifiers": [ [ "species_10591548", "catalyst" ] ], "additional_components": [ "CHEBI:90799", "CHEBI:47923", "CHEBI:47923", "CHEBI:90799", "DDB_G0267874" ] }, "reaction_10581636": { "compartment": "compartment_7660", "id": "reaction_10581636", "reactome": "R-DDI-75861", "name": "NTP Binds Active Site of RNA Polymerase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581630", "species_30595" ], "products": [ "species_10581634" ], "modifiers": [], "additional_components": [ "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "species_110614", "species_113592", "species_29494", "species_29438", "species_110614", "species_113592", "species_29494", "species_29438", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617" ] }, "reaction_10581644": { "compartment": "compartment_7660", "id": "reaction_10581644", "reactome": "R-DDI-75864", "name": "Newly Formed Phosphodiester Bond Stabilized and PPi Released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581642" ], "products": [ "species_10580924", "species_113541" ], "modifiers": [], "additional_components": [ "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617" ] }, "reaction_10581646": { "compartment": "compartment_7660", "id": "reaction_10581646", "reactome": "R-DDI-75866", "name": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581634" ], "products": [ "species_10581642" ], "modifiers": [], "additional_components": [ "species_110614", "species_113592", "species_29494", "species_29438", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617" ] }, "reaction_10581767": { "compartment": "compartment_7660", "id": "reaction_10581767", "reactome": "R-DDI-75949", "name": "RNA Polymerase II Promoter Opening: First Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10581638" ], "products": [ "species_113550", "species_113582", "species_10581630" ], "modifiers": [ [ "species_10580699", "catalyst" ] ], "additional_components": [ "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54FD6", "DDB_G0290929", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729" ] }, "reaction_10581650": { "compartment": "compartment_7660", "id": "reaction_10581650", "reactome": "R-DDI-75869", "name": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581608", "species_30595" ], "products": [ "species_10580844", "species_113541", "species_10581648" ], "modifiers": [ [ "species_10578889", "catalyst" ] ], "additional_components": [ "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "species_110614", "species_113592", "species_29494", "species_29438", "DDB_G0290929", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10626119": { "compartment": "compartment_7660", "id": "reaction_10626119", "reactome": "R-DDI-9613494", "name": "Unwinding of DNA for the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10581608" ], "products": [ "species_164121", "species_10581608", "species_113541" ], "modifiers": [ [ "species_10580699", "catalyst" ] ], "additional_components": [ "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729" ] }, "reaction_10581611": { "compartment": "compartment_7660", "id": "reaction_10581611", "reactome": "R-DDI-75850", "name": "Addition of the third nucleotide on the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580924", "species_30595" ], "products": [ "species_10581608", "species_113541" ], "modifiers": [ [ "species_10578889", "catalyst" ] ], "additional_components": [ "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "species_110614", "species_113592", "species_29494", "species_29438", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10626121": { "compartment": "compartment_7660", "id": "reaction_10626121", "reactome": "R-DDI-9613497", "name": "Unwinding DNA for the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580924", "species_30595" ], "products": [ "species_10580924", "species_113541" ], "modifiers": [ [ "species_10580699", "catalyst" ] ], "additional_components": [ "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "species_110614", "species_113592", "species_29494", "species_29438", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729" ] }, "reaction_10582826": { "compartment": "compartment_7660", "id": "reaction_10582826", "reactome": "R-DDI-111264", "name": "Addition of nucleotides between position +11 and +30", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582331", "species_30595" ], "products": [ "species_113541", "species_10582368" ], "modifiers": [ [ "species_10578889", "catalyst" ] ], "additional_components": [ "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "species_110614", "species_113592", "species_29494", "species_29438", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10582333": { "compartment": "compartment_7660", "id": "reaction_10582333", "reactome": "R-DDI-76576", "name": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581677", "species_30595" ], "products": [ "species_10582331", "species_113541" ], "modifiers": [ [ "species_10578889", "catalyst" ] ], "additional_components": [ "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "species_110614", "species_113592", "species_29494", "species_29438", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10581679": { "compartment": "compartment_7660", "id": "reaction_10581679", "reactome": "R-DDI-75873", "name": "Addition of Nucleotides 5 through 9 on the growing Transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10581648" ], "products": [ "species_10580910", "species_10581677", "species_10580922", "species_10580839", "species_113541" ], "modifiers": [ [ "species_10578889", "catalyst" ] ], "additional_components": [ "species_110614", "species_113592", "species_29494", "species_29438", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10590450": { "compartment": "compartment_17951", "id": "reaction_10590450", "reactome": "R-DDI-389986", "name": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_389894" ], "products": [ "species_389982" ], "modifiers": [ [ "species_10586623", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10590437": { "compartment": "compartment_17951", "id": "reaction_10590437", "reactome": "R-DDI-389889", "name": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389893" ], "products": [ "species_113575", "species_389894" ], "modifiers": [ [ "species_10590434", "catalyst" ] ], "additional_components": [ "species_113596", "Q54LF1", "DDB_G0286669", "Q54GQ6", "DDB_G0289993" ] }, "reaction_10590452": { "compartment": "compartment_17951", "id": "reaction_10590452", "reactome": "R-DDI-389995", "name": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389982", "species_192307" ], "products": [ "species_193465", "species_389996", "species_192305" ], "modifiers": [ [ "species_10586623", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10590447": { "compartment": "compartment_17951", "id": "reaction_10590447", "reactome": "R-DDI-389891", "name": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389893" ], "products": [ "species_113575", "species_389894" ], "modifiers": [ [ "species_10590444", "catalyst" ] ], "additional_components": [ "species_113596", "Q8MMS1", "DDB_G0277477" ] }, "reaction_10619972": { "compartment": "compartment_7660", "id": "reaction_10619972", "reactome": "R-DDI-8866601", "name": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_8866574" ], "products": [ "species_8866608", "species_8866567" ], "modifiers": [ [ "species_10619969", "catalyst" ], [ "species_29892", "catalyst" ] ], "additional_components": [ "B0G107", "DDB_G0272484", "species_29426" ] }, "reaction_10601235": { "compartment": "compartment_70101", "id": "reaction_10601235", "reactome": "R-DDI-2509827", "name": "ITPA hydrolyses ITP to IMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2509836" ], "products": [ "species_111294", "species_29602" ], "modifiers": [ [ "species_10601232", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54LQ6", "DDB_G0286495" ] }, "reaction_10581202": { "compartment": "compartment_70101", "id": "reaction_10581202", "reactome": "R-DDI-74247", "name": "Hypoxanthine + H2O + O2 => Xanthine + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113599", "species_29356", "species_29368" ], "products": [ "species_29408", "species_30064" ], "modifiers": [ [ "species_10581199", "catalyst" ] ], "additional_components": [ "CHEBI:44074", "species_113596", "Q54FB7", "DDB_G0291047" ] }, "reaction_10581222": { "compartment": "compartment_70101", "id": "reaction_10581222", "reactome": "R-DDI-74255", "name": "Guanine + H2O => Xanthine + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_83956" ], "products": [ "species_31633", "species_30064" ], "modifiers": [ [ "species_10581219", "catalyst" ] ], "additional_components": [ "Q86AW9", "DDB_G0277743", "species_29426" ] }, "reaction_10601238": { "compartment": "compartment_70101", "id": "reaction_10601238", "reactome": "R-DDI-2509831", "name": "ITPA hydrolyses XTP to XMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509848", "species_29356" ], "products": [ "species_111294", "species_111584" ], "modifiers": [ [ "species_10601232", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54LQ6", "DDB_G0286495" ] }, "reaction_10601241": { "compartment": "compartment_70101", "id": "reaction_10601241", "reactome": "R-DDI-2509838", "name": "ITPA hydrolyses dITP to dIMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509835", "species_29356" ], "products": [ "species_111294", "species_109330" ], "modifiers": [ [ "species_10601232", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54LQ6", "DDB_G0286495" ] }, "reaction_10581224": { "compartment": "compartment_70101", "id": "reaction_10581224", "reactome": "R-DDI-74258", "name": "Xanthine + H2O + O2 => Urate + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29368", "species_30064" ], "products": [ "species_30034", "species_29408" ], "modifiers": [ [ "species_10581199", "catalyst" ] ], "additional_components": [ "CHEBI:44074", "species_113596", "Q54FB7", "DDB_G0291047" ] }, "reaction_10581212": { "compartment": "compartment_70101", "id": "reaction_10581212", "reactome": "R-DDI-74248", "name": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500120", "species_29356" ], "products": [ "species_29372", "species_500118" ], "modifiers": [ [ "species_10581209", "catalyst" ] ], "additional_components": [ "species_29602", "species_109330", "species_113578", "CHEBI:16192", "CHEBI:17172", "CHEBI:28997", "species_83921", "CHEBI:16750", "Q54XC1", "DDB_G0279053", "species_29926" ] }, "reaction_10612835": { "compartment": "compartment_7660", "id": "reaction_10612835", "reactome": "R-DDI-6788810", "name": "AK6 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_6788813" ], "products": [ "species_113582", "species_6788807" ], "modifiers": [ [ "species_10612832", "catalyst" ] ], "additional_components": [ "CHEBI:15918", "species_109395", "species_76577", "species_109386", "species_110094", "CHEBI:16174", "CHEBI:28846", "species_29370", "DDB_G0278493" ] }, "reaction_10582661": { "compartment": "compartment_70101", "id": "reaction_10582661", "reactome": "R-DDI-110137", "name": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_6788782" ], "products": [ "species_6788778", "species_113592" ], "modifiers": [ [ "species_10582658", "catalyst" ] ], "additional_components": [ "species_29370", "CHEBI:28846", "CHEBI:16174", "species_110094", "species_76577", "species_109395", "CHEBI:15918", "species_109386", "Q54CT8", "DDB_G0292730", "Q54QJ9", "DDB_G0283805" ] }, "reaction_10582663": { "compartment": "compartment_70101", "id": "reaction_10582663", "reactome": "R-DDI-110138", "name": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788778", "species_113592" ], "products": [ "species_29370", "species_6788782" ], "modifiers": [ [ "species_10582658", "catalyst" ] ], "additional_components": [ "species_76577", "species_109395", "CHEBI:15918", "species_109386", "species_29370", "CHEBI:28846", "CHEBI:16174", "species_110094", "Q54CT8", "DDB_G0292730", "Q54QJ9", "DDB_G0283805" ] }, "reaction_10580715": { "compartment": "compartment_70101", "id": "reaction_10580715", "reactome": "R-DDI-73788", "name": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500071" ], "products": [ "species_29370", "species_500077" ], "modifiers": [ [ "species_10580712", "catalyst" ] ], "additional_components": [ "species_113578", "CHEBI:16192", "species_29420", "CHEBI:28862", "DDB_G0279001" ] }, "reaction_10580555": { "compartment": "compartment_70101", "id": "reaction_10580555", "reactome": "R-DDI-73635", "name": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_499997", "species_113592" ], "products": [ "species_29370", "species_499999" ], "modifiers": [ [ "species_10580552", "catalyst" ] ], "additional_components": [ "species_500742", "species_109366", "CHEBI:28850", "CHEBI:18075", "Q54GN2", "DDB_G0290033" ] }, "reaction_10593837": { "compartment": "compartment_5460", "id": "reaction_10593837", "reactome": "R-DDI-482804", "name": "(d)NDP + ATP <=> (d)NTP + ADP (NME4)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_482803" ], "products": [ "species_113581", "species_482807" ], "modifiers": [ [ "species_10593834", "catalyst" ] ], "additional_components": [ "CHEBI:18075", "species_29420", "CHEBI:28850", "CHEBI:28862", "species_110096", "CHEBI:16174", "CHEBI:28846", "species_110094", "species_110614", "species_29438", "species_500739", "species_29892", "species_29494", "species_29604", "species_30185", "species_30187", "P34093", "DDB_G0279911" ] }, "reaction_10582668": { "compartment": "compartment_70101", "id": "reaction_10582668", "reactome": "R-DDI-110144", "name": "ADP + ADP <=> AMP + ATP [AK2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370" ], "products": [ "species_113592", "species_76577" ], "modifiers": [ [ "species_10582665", "catalyst" ] ], "additional_components": [ "DDB_G0283805" ] }, "reaction_10616659": { "compartment": "compartment_70101", "id": "reaction_10616659", "reactome": "R-DDI-6806877", "name": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6806885" ], "products": [ "species_29370", "species_6806881" ], "modifiers": [ [ "species_10616656", "catalyst" ] ], "additional_components": [ "P34093", "DDB_G0279911" ] }, "reaction_10580565": { "compartment": "compartment_70101", "id": "reaction_10580565", "reactome": "R-DDI-73647", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_29494", "species_29472" ], "products": [ "species_29372", "species_29404", "species_29370", "species_110614" ], "modifiers": [ [ "species_10580562", "catalyst" ] ], "additional_components": [ "Q54V77", "DDB_G0280567" ] }, "reaction_10580407": { "compartment": "compartment_70101", "id": "reaction_10580407", "reactome": "R-DDI-73548", "name": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500009", "species_113592" ], "products": [ "species_29370", "species_500006" ], "modifiers": [ [ "species_10580404", "catalyst" ] ], "additional_components": [ "species_109395", "CHEBI:15918", "species_109402", "species_110096", "CHEBI:28846", "species_110094", "DDB_G0287495" ] }, "reaction_10593654": { "compartment": "compartment_70101", "id": "reaction_10593654", "reactome": "R-DDI-482619", "name": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_482627" ], "products": [ "species_29370", "species_482625" ], "modifiers": [ [ "species_10593651", "catalyst" ] ], "additional_components": [ "species_110096", "CHEBI:28846", "CHEBI:16174", "species_29420", "CHEBI:28850", "CHEBI:28862", "CHEBI:18075", "species_110094", "species_29892", "species_29604", "species_30185", "species_29494", "species_30187", "species_110614", "species_500739", "species_29438", "P34093", "DDB_G0279911" ] }, "reaction_10612827": { "compartment": "compartment_5460", "id": "reaction_10612827", "reactome": "R-DDI-6788798", "name": "AK4 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_6788802" ], "products": [ "species_113581", "species_6788801" ], "modifiers": [ [ "species_10612824", "catalyst" ] ], "additional_components": [ "species_109395", "species_109386", "species_76577", "CHEBI:15918", "species_29370", "CHEBI:16174", "CHEBI:28846", "species_110094", "DDB_G0292730" ] }, "reaction_10593851": { "compartment": "compartment_70101", "id": "reaction_10593851", "reactome": "R-DDI-504054", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_29494", "species_29472" ], "products": [ "species_29372", "species_29404", "species_29370", "species_110614" ], "modifiers": [ [ "species_10593848", "catalyst" ] ], "additional_components": [ "Q54V77", "DDB_G0280567" ] }, "reaction_10580575": { "compartment": "compartment_7660", "id": "reaction_10580575", "reactome": "R-DDI-73666", "name": "dUTP + H2O => dUMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_500739" ], "products": [ "species_113541", "species_500742" ], "modifiers": [ [ "species_10580572", "catalyst" ] ], "additional_components": [ "Q54BW5", "DDB_G0293374" ] }, "reaction_10580545": { "compartment": "compartment_70101", "id": "reaction_10580545", "reactome": "R-DDI-73632", "name": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_83928" ], "products": [ "species_29370", "species_109366" ], "modifiers": [ [ "species_10580542", "catalyst" ] ], "additional_components": [ "Q27564", "DDB_G0289179" ] }, "reaction_10580529": { "compartment": "compartment_70101", "id": "reaction_10580529", "reactome": "R-DDI-73608", "name": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500829" ], "products": [ "species_500430", "species_31633" ], "modifiers": [ [ "species_10580526", "catalyst" ] ], "additional_components": [ "CHEBI:15698", "CHEBI:17562", "CHEBI:16450", "CHEBI:16704", "species_29426", "Q54I82", "DDB_G0288933" ] }, "reaction_10623936": { "compartment": "compartment_70101", "id": "reaction_10623936", "reactome": "R-DDI-8954327", "name": "UCKL1 phosphorylates urindine, cytidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500759" ], "products": [ "species_500761", "species_29370" ], "modifiers": [ [ "species_10623933", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:17562", "species_109395", "species_109402", "DDB_G0274559" ] }, "reaction_10582628": { "compartment": "compartment_70101", "id": "reaction_10582628", "reactome": "R-DDI-109903", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500759" ], "products": [ "species_500761", "species_29370" ], "modifiers": [ [ "species_10582625", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:17562", "species_109395", "species_109402", "Q55EL3", "DDB_G0269034", "Q8T154", "DDB_G0274559" ] }, "reaction_10580519": { "compartment": "compartment_70101", "id": "reaction_10580519", "reactome": "R-DDI-73599", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500759" ], "products": [ "species_500761", "species_29370" ], "modifiers": [ [ "species_10580516", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:17562", "species_109395", "species_109402", "Q8T154", "DDB_G0274559", "Q55EL3", "DDB_G0269034" ] }, "reaction_10581238": { "compartment": "compartment_70101", "id": "reaction_10581238", "reactome": "R-DDI-74372", "name": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83962", "species_500244" ], "products": [ "species_29372", "species_500430" ], "modifiers": [ [ "species_10581235", "catalyst" ] ], "additional_components": [ "CHEBI:28542", "species_112016", "CHEBI:16450", "CHEBI:16704", "Q54PM8", "DDB_G0284431" ] }, "reaction_10580502": { "compartment": "compartment_70101", "id": "reaction_10580502", "reactome": "R-DDI-73598", "name": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500829", "species_113592" ], "products": [ "species_500828", "species_29370" ], "modifiers": [ [ "species_10580499", "catalyst" ] ], "additional_components": [ "CHEBI:15698", "CHEBI:17562", "species_109395", "CHEBI:15918", "Q54YL2", "DDB_G0278191", "species_29926" ] }, "reaction_10582606": { "compartment": "compartment_5460", "id": "reaction_10582606", "reactome": "R-DDI-109759", "name": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_500822" ], "products": [ "species_113581", "species_500823" ], "modifiers": [ [ "species_10582603", "catalyst" ] ], "additional_components": [ "species_83928", "CHEBI:16450", "CHEBI:15698", "species_109366", "species_500742", "CHEBI:15918", "DDB_G0278191" ] }, "reaction_10582353": { "compartment": "compartment_70101", "id": "reaction_10582353", "reactome": "R-DDI-76590", "name": "AMP + H2O => IMP + NH4+ (AMPD)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_76577" ], "products": [ "species_29602", "species_31633" ], "modifiers": [ [ "species_10582350", "catalyst" ] ], "additional_components": [ "Q54DD0", "DDB_G0292266" ] }, "reaction_10581184": { "compartment": "compartment_5460", "id": "reaction_10581184", "reactome": "R-DDI-74207", "name": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_500224" ], "products": [ "species_113581", "species_500222" ], "modifiers": [ [ "species_10581181", "catalyst" ] ], "additional_components": [ "CHEBI:17172", "CHEBI:17256", "CHEBI:28997", "CHEBI:16192", "species_109386", "species_109330", "Q54YL2", "DDB_G0278191" ] }, "reaction_10582544": { "compartment": "compartment_70101", "id": "reaction_10582544", "reactome": "R-DDI-109624", "name": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500173", "species_113592" ], "products": [ "species_500088", "species_29370" ], "modifiers": [ [ "species_10582541", "catalyst" ] ], "additional_components": [ "species_83909", "CHEBI:17256", "species_76577", "species_109386", "species_29926", "Q54MB5", "DDB_G0286057" ] }, "reaction_10581192": { "compartment": "compartment_70101", "id": "reaction_10581192", "reactome": "R-DDI-74241", "name": "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH4+ (ADA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500173" ], "products": [ "species_500172", "species_31633" ], "modifiers": [ [ "species_10581189", "catalyst" ] ], "additional_components": [ "species_83909", "CHEBI:17256", "CHEBI:28997", "species_83921", "DDB_G0287371" ] }, "reaction_10582554": { "compartment": "compartment_70101", "id": "reaction_10582554", "reactome": "R-DDI-109671", "name": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500201", "species_113592" ], "products": [ "species_29370", "species_500199" ], "modifiers": [ [ "species_10580499", "catalyst" ] ], "additional_components": [ "CHEBI:17172", "CHEBI:17256", "species_109386", "CHEBI:16192", "Q54YL2", "DDB_G0278191", "species_29926" ] }, "reaction_10580768": { "compartment": "compartment_70101", "id": "reaction_10580768", "reactome": "R-DDI-73813", "name": "GAR + 10-Formyl-THF => FGAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111338", "species_419151" ], "products": [ "species_111354", "species_111355" ], "modifiers": [ [ "species_10580754", "catalyst" ] ], "additional_components": [ "DDB_G0290121" ] }, "reaction_10580771": { "compartment": "compartment_70101", "id": "reaction_10580771", "reactome": "R-DDI-73814", "name": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111292", "species_113592", "species_29424" ], "products": [ "species_29372", "species_111338", "species_29370" ], "modifiers": [ [ "species_10580754", "catalyst" ] ], "additional_components": [ "DDB_G0290121" ] }, "reaction_10580723": { "compartment": "compartment_70101", "id": "reaction_10580723", "reactome": "R-DDI-73792", "name": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_111584", "species_29472" ], "products": [ "species_111294", "species_29404", "species_113578", "species_76577" ], "modifiers": [ [ "species_10580720", "catalyst" ] ], "additional_components": [ "DDB_G0281551" ] }, "reaction_10580757": { "compartment": "compartment_70101", "id": "reaction_10580757", "reactome": "R-DDI-73810", "name": "FGAM + ATP => AIR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111369" ], "products": [ "species_29372", "species_111370", "species_29370" ], "modifiers": [ [ "species_10580754", "catalyst" ] ], "additional_components": [ "DDB_G0290121" ] }, "reaction_10582854": { "compartment": "compartment_70101", "id": "reaction_10582854", "reactome": "R-DDI-111524", "name": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29448", "species_29602" ], "products": [ "species_29372", "species_29420", "species_35141" ], "modifiers": [ [ "species_10582851", "catalyst" ], [ "species_113578", "inhibitor" ], [ "species_29420", "inhibitor" ], [ "species_30014", "inhibitor" ], [ "species_35141", "inhibitor" ] ], "additional_components": [ "species_29926", "P21900", "DDB_G0285429" ] }, "reaction_10627338": { "compartment": "compartment_70101", "id": "reaction_10627338", "reactome": "R-DDI-9678749", "name": "IMPDH tetramers binds IMPDH inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9678719", "species_10580730" ], "products": [ "species_10580733" ], "modifiers": [], "additional_components": [ "Q54QQ0", "DDB_G0283701", "Q54QQ0", "DDB_G0283701" ] }, "reaction_10580746": { "compartment": "compartment_70101", "id": "reaction_10580746", "reactome": "R-DDI-73797", "name": "FAICAR => IMP + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111427" ], "products": [ "species_29356", "species_29602" ], "modifiers": [ [ "species_10580743", "catalyst" ] ], "additional_components": [ "Q86L14", "DDB_G0277087" ] }, "reaction_10580765": { "compartment": "compartment_70101", "id": "reaction_10580765", "reactome": "R-DDI-73812", "name": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111354", "species_113592", "species_29472" ], "products": [ "species_29372", "species_29404", "species_29370", "species_111369" ], "modifiers": [ [ "species_10580762", "catalyst" ] ], "additional_components": [ "DDB_G0288145" ] }, "reaction_10580749": { "compartment": "compartment_70101", "id": "reaction_10580749", "reactome": "R-DDI-73798", "name": "AICAR + 10-Formyl-THF => FAICAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_419151", "species_111409" ], "products": [ "species_111355", "species_111427" ], "modifiers": [ [ "species_10580743", "catalyst" ] ], "additional_components": [ "Q86L14", "DDB_G0277087" ] }, "reaction_10580735": { "compartment": "compartment_70101", "id": "reaction_10580735", "reactome": "R-DDI-73794", "name": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29602", "species_29360" ], "products": [ "species_70106", "species_111584", "species_73473" ], "modifiers": [ [ "species_10580730", "catalyst" ], [ "species_111584", "inhibitor" ], [ "species_10580733", "inhibitor" ] ], "additional_components": [ "Q54QQ0", "DDB_G0283701", "Q54QQ0", "DDB_G0283701" ] }, "reaction_10580433": { "compartment": "compartment_70101", "id": "reaction_10580433", "reactome": "R-DDI-73573", "name": "CAD hexamer transforms CAP to N-carb-L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111647", "species_29448" ], "products": [ "species_111628", "species_29372" ], "modifiers": [ [ "species_10580427", "catalyst" ] ], "additional_components": [ "P20054", "DDB_G0276335" ] }, "reaction_10580417": { "compartment": "compartment_70101", "id": "reaction_10580417", "reactome": "R-DDI-73564", "name": "UMPS dimer decarboxylates OMP to UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111629" ], "products": [ "species_109402", "species_113528" ], "modifiers": [ [ "species_10580414", "catalyst" ] ], "additional_components": [ "P09556", "DDB_G0280041" ] }, "reaction_10580436": { "compartment": "compartment_70101", "id": "reaction_10580436", "reactome": "R-DDI-73577", "name": "CAD hexamer transforms L-Gln to CAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111627", "species_113592", "species_29472" ], "products": [ "species_111647", "species_29372", "species_29404", "species_29370" ], "modifiers": [ [ "species_10580427", "catalyst" ] ], "additional_components": [ "P20054", "DDB_G0276335" ] }, "reaction_10580420": { "compartment": "compartment_70101", "id": "reaction_10580420", "reactome": "R-DDI-73567", "name": "UMPS dimer transfers phoshoribosyl group to ORO to form OMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_76632" ], "products": [ "species_111294", "species_111629" ], "modifiers": [ [ "species_10580414", "catalyst" ] ], "additional_components": [ "P09556", "DDB_G0280041" ] }, "reaction_10580430": { "compartment": "compartment_70101", "id": "reaction_10580430", "reactome": "R-DDI-73571", "name": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111628", "species_70106" ], "products": [ "species_29356", "species_76630" ], "modifiers": [ [ "species_10580427", "catalyst" ] ], "additional_components": [ "P20054", "DDB_G0276335" ] }, "reaction_10611880": { "compartment": "compartment_12045", "id": "reaction_10611880", "reactome": "R-DDI-5696021", "name": "ADPGK:Mg2+ phosphorylates Glc to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_70113" ], "products": [ "species_30537", "species_76577" ], "modifiers": [ [ "species_10611877", "catalyst" ] ], "additional_components": [ "species_29926", "Q54K22", "DDB_G0287631" ] }, "reaction_10578788": { "compartment": "compartment_70101", "id": "reaction_10578788", "reactome": "R-DDI-71802", "name": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29512" ], "products": [ "species_29370", "species_30533" ], "modifiers": [ [ "species_10578785", "catalyst" ], [ "species_30533", "catalyst" ] ], "additional_components": [ "Q54SI2", "DDB_G0282759", "Q551Y6", "DDB_G0282759" ] }, "reaction_10577647": { "compartment": "compartment_70101", "id": "reaction_10577647", "reactome": "R-DDI-70262", "name": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30533" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10577644", "catalyst" ] ], "additional_components": [ "Q54SI2", "DDB_G0282759", "Q551Y6", "DDB_G0282759" ] }, "reaction_10578671": { "compartment": "compartment_70101", "id": "reaction_10578671", "reactome": "R-DDI-71670", "name": "phosphoenolpyruvate + ADP => pyruvate + ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29370", "species_29492" ], "products": [ "species_113592", "species_29398" ], "modifiers": [ [ "species_10578668", "catalyst" ], [ "species_30014", "catalyst" ], [ "species_76183", "inhibitor" ], [ "species_29358", "inhibitor" ], [ "species_30389", "inhibitor" ] ], "additional_components": [ "Q54RF5", "DDB_G0283247", "species_29926", "species_74126" ] }, "reaction_10613720": { "compartment": "compartment_70101", "id": "reaction_10613720", "reactome": "R-DDI-6798335", "name": "BPGM dimer isomerises 1,3BPG to 2,3BPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29800" ], "products": [ "species_6798337" ], "modifiers": [ [ "species_10613717", "catalyst" ] ], "additional_components": [ "Q54NE6", "DDB_G0285311" ] }, "reaction_10616029": { "compartment": "compartment_70101", "id": "reaction_10616029", "reactome": "R-DDI-6799604", "name": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_449701" ], "products": [ "species_29512", "species_31633" ], "modifiers": [ [ "species_10616026", "catalyst" ] ], "additional_components": [ "Q54XK9", "DDB_G0278873" ] }, "reaction_10623996": { "compartment": "compartment_70101", "id": "reaction_10623996", "reactome": "R-DDI-8955760", "name": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30537", "species_29800" ], "products": [ "species_70106", "species_8955759", "species_29728" ], "modifiers": [ [ "species_10577658", "catalyst" ] ], "additional_components": [ "species_29926", "Q54UQ2", "DDB_G0280897" ] }, "reaction_10606595": { "compartment": "compartment_70101", "id": "reaction_10606595", "reactome": "R-DDI-5661256", "name": "AKR1A1 reduces D-glucuronate to L-gulonate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_5661264", "species_29364" ], "products": [ "species_29366", "species_5661268" ], "modifiers": [ [ "species_10606592", "catalyst" ] ], "additional_components": [ "DDB_G0293850" ] }, "reaction_10626289": { "compartment": "compartment_161320", "id": "reaction_10626289", "reactome": "R-DDI-9638075", "name": "HEXB cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065269" ], "products": [ "species_1605658", "species_2105025" ], "modifiers": [ [ "species_10598378", "catalyst" ] ], "additional_components": [ "P13723", "DDB_G0287033" ] }, "reaction_10600151": { "compartment": "compartment_161320", "id": "reaction_10600151", "reactome": "R-DDI-2105001", "name": "HEXA cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065269" ], "products": [ "species_1605658", "species_2105025" ], "modifiers": [ [ "species_10598376", "catalyst" ] ], "additional_components": [ "Q54K55", "DDB_G0287597", "Q54SC9", "DDB_G0282539", "Q54K56", "DDB_G0287659", "Q54MU9", "DDB_G0285647", "P13723", "DDB_G0287033" ] }, "reaction_10599228": { "compartment": "compartment_161320", "id": "reaction_10599228", "reactome": "R-DDI-1793186", "name": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2105025" ], "products": [ "species_2104993", "species_1678617" ], "modifiers": [ [ "species_10599145", "catalyst" ] ], "additional_components": [ "DDB_G0288289" ] }, "reaction_10594113": { "compartment": "compartment_20699", "id": "reaction_10594113", "reactome": "R-DDI-741449", "name": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471" ], "products": [ "species_741440" ], "modifiers": [ [ "species_10594110", "catalyst" ] ], "additional_components": [ "DDB_G0269602" ] }, "reaction_10591509": { "compartment": "compartment_876", "id": "reaction_10591509", "reactome": "R-DDI-427555", "name": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_427648" ], "products": [ "species_70106", "species_174375" ], "modifiers": [ [ "species_10591506", "catalyst" ] ], "additional_components": [ "B0G157", "DDB_G0286611", "Q55FK8", "DDB_G0286611" ] }, "reaction_10598500": { "compartment": "compartment_161320", "id": "reaction_10598500", "reactome": "R-DDI-1630306", "name": "GLB1 hydrolyses a glycosaminoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2104997" ], "products": [ "species_1605637", "species_2104995" ], "modifiers": [ [ "species_10598338", "catalyst" ] ], "additional_components": [ "DDB_G0290217" ] }, "reaction_10598503": { "compartment": "compartment_161320", "id": "reaction_10598503", "reactome": "R-DDI-1638053", "name": "HEXA cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2105012" ], "products": [ "species_2105010", "species_1605658" ], "modifiers": [ [ "species_10598376", "catalyst" ] ], "additional_components": [ "Q54K55", "DDB_G0287597", "Q54SC9", "DDB_G0282539", "Q54K56", "DDB_G0287659", "Q54MU9", "DDB_G0285647", "P13723", "DDB_G0287033" ] }, "reaction_10626293": { "compartment": "compartment_161320", "id": "reaction_10626293", "reactome": "R-DDI-9638078", "name": "HEXB cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2105012" ], "products": [ "species_2105010", "species_1605658" ], "modifiers": [ [ "species_10598378", "catalyst" ] ], "additional_components": [ "P13723", "DDB_G0287033" ] }, "reaction_10626002": { "compartment": "compartment_17963", "id": "reaction_10626002", "reactome": "R-DDI-9603984", "name": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9033790", "species_205683" ], "products": [ "species_9605593", "species_205689" ], "modifiers": [ [ "species_10625999", "catalyst" ] ], "additional_components": [ "Q54PK0", "DDB_G0284775", "Q54PJ9", "DDB_G0284775", "Q54RA6", "DDB_G0284775", "Q54PK3", "DDB_G0284551", "Q86J24", "DDB_G0284775", "Q54PH9", "DDB_G0284467", "Q54P60", "DDB_G0284775" ] }, "reaction_10626007": { "compartment": "compartment_17963", "id": "reaction_10626007", "reactome": "R-DDI-9605609", "name": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605595", "species_205683" ], "products": [ "species_9605615", "species_205689" ], "modifiers": [ [ "species_10611506", "catalyst" ] ], "additional_components": [ "Q54PK0", "DDB_G0284775", "Q86J24", "DDB_G0284775", "Q54P60", "DDB_G0284775", "Q54PH9", "DDB_G0284467", "Q54PK3", "DDB_G0284551", "Q54RA6", "DDB_G0284775", "Q54PJ9", "DDB_G0284775" ] }, "reaction_10626004": { "compartment": "compartment_17963", "id": "reaction_10626004", "reactome": "R-DDI-9603986", "name": "FUT3 transfers Fuc to Type 1 chains to form LeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9036984", "species_205683" ], "products": [ "species_205689", "species_9605607" ], "modifiers": [ [ "species_10611506", "catalyst" ] ], "additional_components": [ "Q54PK0", "DDB_G0284775", "Q86J24", "DDB_G0284775", "Q54P60", "DDB_G0284775", "Q54PH9", "DDB_G0284467", "Q54PK3", "DDB_G0284551", "Q54RA6", "DDB_G0284775", "Q54PJ9", "DDB_G0284775" ] }, "reaction_10626009": { "compartment": "compartment_17963", "id": "reaction_10626009", "reactome": "R-DDI-9605644", "name": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605649", "species_205683" ], "products": [ "species_205689", "species_9605651" ], "modifiers": [ [ "species_10611506", "catalyst" ] ], "additional_components": [ "Q54PK0", "DDB_G0284775", "Q86J24", "DDB_G0284775", "Q54P60", "DDB_G0284775", "Q54PH9", "DDB_G0284467", "Q54PK3", "DDB_G0284551", "Q54RA6", "DDB_G0284775", "Q54PJ9", "DDB_G0284775" ] }, "reaction_10626030": { "compartment": "compartment_17963", "id": "reaction_10626030", "reactome": "R-DDI-9605682", "name": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605685", "species_205683" ], "products": [ "species_9605661", "species_205689" ], "modifiers": [ [ "species_10626027", "catalyst" ] ], "additional_components": [ "Q54PK0", "DDB_G0284775", "Q86J24", "DDB_G0284775", "Q54P60", "DDB_G0284775", "Q54PH9", "DDB_G0284467", "Q54PK3", "DDB_G0284551", "Q54RA6", "DDB_G0284775", "Q54PJ9", "DDB_G0284775" ] }, "reaction_10606317": { "compartment": "compartment_17963", "id": "reaction_10606317", "reactome": "R-DDI-5653873", "name": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_964746" ], "modifiers": [ [ "species_10606314", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10577719": { "compartment": "compartment_70101", "id": "reaction_10577719", "reactome": "R-DDI-70427", "name": "PGM:Mg2+ isomerise G1P to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29548" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10577660", "catalyst" ] ], "additional_components": [ "Q54UQ2", "DDB_G0280897", "species_29926" ] }, "reaction_10615984": { "compartment": "compartment_70101", "id": "reaction_10615984", "reactome": "R-DDI-6799545", "name": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6799540" ], "products": [ "species_429579", "species_6799543" ], "modifiers": [ [ "species_10615981", "catalyst" ] ], "additional_components": [ "species_29426", "Q54K67", "DDB_G0287577" ] }, "reaction_10619249": { "compartment": "compartment_161320", "id": "reaction_10619249", "reactome": "R-DDI-8853710", "name": "MANBA hydrolyses GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8853719" ], "products": [ "species_1678743", "species_6799594" ], "modifiers": [ [ "species_10619246", "catalyst" ] ], "additional_components": [ "DDB_G0275917" ] }, "reaction_10616013": { "compartment": "compartment_161320", "id": "reaction_10616013", "reactome": "R-DDI-6799581", "name": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6799577", "species_1605715" ], "products": [ "species_6799594", "species_8853719" ], "modifiers": [ [ "species_10616010", "catalyst" ] ], "additional_components": [ "Q54YF7", "DDB_G0278259", "P34098", "DDB_G0292206", "Q1ZXI8", "DDB_G0278651", "Q55ER0", "DDB_G0268994", "Q54YC4", "DDB_G0278653", "species_29426" ] }, "reaction_10619244": { "compartment": "compartment_161320", "id": "reaction_10619244", "reactome": "R-DDI-8853686", "name": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_8853396" ], "products": [ "species_6799577", "species_6799594" ], "modifiers": [ [ "species_10619241", "catalyst" ] ], "additional_components": [ "P34098", "DDB_G0292206", "species_29426" ] }, "reaction_10593362": { "compartment": "compartment_70101", "id": "reaction_10593362", "reactome": "R-DDI-453339", "name": "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_10578646" ], "products": [ "species_29548", "species_10593360" ], "modifiers": [ [ "species_10578628", "catalyst" ] ], "additional_components": [ "Q54L24", "DDB_G0286945", "species_266099", "species_266099", "Q54L24", "DDB_G0286945", "Q00766", "DDB_G0281383" ] }, "reaction_10593364": { "compartment": "compartment_70101", "id": "reaction_10593364", "reactome": "R-DDI-453342", "name": "PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10578574", "species_76577" ], "products": [ "species_10593354" ], "modifiers": [ [ "species_113592", "inhibitor" ], [ "species_30537", "inhibitor" ] ], "additional_components": [ "P34114", "DDB_G0291123", "Q00766", "DDB_G0281383", "species_76577", "P34114", "DDB_G0291123", "Q00766", "DDB_G0281383" ] }, "reaction_10625828": { "compartment": "compartment_161320", "id": "reaction_10625828", "reactome": "R-DDI-9036727", "name": "GAA hydrolyzes lysosomal glycogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_10625815" ], "products": [ "species_1605745", "species_10625819" ], "modifiers": [ [ "species_10625825", "catalyst" ] ], "additional_components": [ "species_266099", "Q54L24", "DDB_G0286945", "species_266099", "Q54L24", "DDB_G0286945", "Q55D50", "DDB_G0269790" ] }, "reaction_10578619": { "compartment": "compartment_70101", "id": "reaction_10578619", "reactome": "R-DDI-71552", "name": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10578599" ], "products": [ "species_10578611" ], "modifiers": [ [ "species_10578616", "catalyst" ] ], "additional_components": [ "species_266099", "Q54L24", "DDB_G0286945", "species_266099", "Q54L24", "DDB_G0286945", "DDB_G0287569" ] }, "reaction_10578651": { "compartment": "compartment_70101", "id": "reaction_10578651", "reactome": "R-DDI-71593", "name": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10578611" ], "products": [ "species_10578648", "species_70113" ], "modifiers": [ [ "species_10578616", "catalyst" ] ], "additional_components": [ "species_266099", "Q54L24", "DDB_G0286945", "species_266099", "Q54L24", "DDB_G0286945", "DDB_G0287569" ] }, "reaction_10578636": { "compartment": "compartment_70101", "id": "reaction_10578636", "reactome": "R-DDI-71590", "name": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_10578633" ], "products": [ "species_29548", "species_10578597" ], "modifiers": [ [ "species_10578628", "catalyst" ] ], "additional_components": [ "Q54L24", "DDB_G0286945", "species_266099", "Q54L24", "DDB_G0286945", "species_266099", "Q00766", "DDB_G0281383" ] }, "reaction_10602624": { "compartment": "compartment_70101", "id": "reaction_10602624", "reactome": "R-DDI-3322041", "name": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602568", "species_29410" ], "products": [ "species_10602621", "species_110096" ], "modifiers": [ [ "species_10602568", "catalyst" ], [ "species_30537", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945" ] }, "reaction_10602596": { "compartment": "compartment_70101", "id": "reaction_10602596", "reactome": "R-DDI-3322009", "name": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602591", "species_29410" ], "products": [ "species_110096", "species_10602593" ], "modifiers": [ [ "species_10602591", "catalyst" ] ], "additional_components": [ "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945" ] }, "reaction_10602628": { "compartment": "compartment_70101", "id": "reaction_10602628", "reactome": "R-DDI-3322057", "name": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602621" ], "products": [ "species_10602626" ], "modifiers": [ [ "species_10602581", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945", "DDB_G0274105" ] }, "reaction_10577673": { "compartment": "compartment_70101", "id": "reaction_10577673", "reactome": "R-DDI-70286", "name": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29548", "species_29494" ], "products": [ "species_111294", "species_29410" ], "modifiers": [ [ "species_10577670", "catalyst" ] ], "additional_components": [ "Q54YZ0", "DDB_G0277879" ] }, "reaction_10602601": { "compartment": "compartment_70101", "id": "reaction_10602601", "reactome": "R-DDI-3322014", "name": "Autoglucosylation of GYG2 complexed with GYS2-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602598", "species_29410" ], "products": [ "species_10602591", "species_110096" ], "modifiers": [ [ "species_10602598", "catalyst" ] ], "additional_components": [ "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945" ] }, "reaction_10602571": { "compartment": "compartment_70101", "id": "reaction_10602571", "reactome": "R-DDI-3322003", "name": "Autoglucosylation of GYG1 complexed with GYS1-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602566", "species_29410" ], "products": [ "species_10602568", "species_110096" ], "modifiers": [ [ "species_10602566", "catalyst" ] ], "additional_components": [ "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "species_29926", "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945", "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "species_29926" ] }, "reaction_10602605": { "compartment": "compartment_70101", "id": "reaction_10602605", "reactome": "R-DDI-3322016", "name": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602593" ], "products": [ "species_10602603" ], "modifiers": [ [ "species_10602581", "catalyst" ] ], "additional_components": [ "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "DDB_G0274105" ] }, "reaction_10602614": { "compartment": "compartment_70101", "id": "reaction_10602614", "reactome": "R-DDI-3322019", "name": "Autoglucosylation of GYG2 complexed with GYS2-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_10602609" ], "products": [ "species_10602611", "species_110096" ], "modifiers": [ [ "species_10602609", "catalyst" ] ], "additional_components": [ "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945" ] }, "reaction_10602584": { "compartment": "compartment_70101", "id": "reaction_10602584", "reactome": "R-DDI-3322005", "name": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602556" ], "products": [ "species_10602576" ], "modifiers": [ [ "species_10602581", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945", "DDB_G0274105" ] }, "reaction_10602619": { "compartment": "compartment_70101", "id": "reaction_10602619", "reactome": "R-DDI-3322025", "name": "Autoglucosylation of GYG1 complexed with GYS1-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602616", "species_29410" ], "products": [ "species_10602554", "species_110096" ], "modifiers": [ [ "species_10602616", "catalyst" ] ], "additional_components": [ "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "species_29926", "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945", "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "species_29926" ] }, "reaction_10626302": { "compartment": "compartment_70101", "id": "reaction_10626302", "reactome": "R-DDI-9638127", "name": "PGM1:Mg2+ isomerises G6P to G1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30537" ], "products": [ "species_29548" ], "modifiers": [ [ "species_10626297", "catalyst" ] ], "additional_components": [ "Q23919", "DDB_G0288483", "species_29926" ] }, "reaction_10602559": { "compartment": "compartment_70101", "id": "reaction_10602559", "reactome": "R-DDI-3322001", "name": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602554", "species_29410" ], "products": [ "species_10602556", "species_110096" ], "modifiers": [ [ "species_10602554", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945" ] }, "reaction_10624322": { "compartment": "compartment_70101", "id": "reaction_10624322", "reactome": "R-DDI-8982667", "name": "PGM2:Mg2+ isomerises dR1P to dR5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787326" ], "products": [ "species_6787328" ], "modifiers": [ [ "species_10577654", "catalyst" ] ], "additional_components": [ "Q54UQ2", "DDB_G0280897", "species_29926" ] }, "reaction_10578464": { "compartment": "compartment_70101", "id": "reaction_10578464", "reactome": "R-DDI-71299", "name": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29996", "species_29366" ], "products": [ "species_70106", "species_113528", "species_29364", "species_29732" ], "modifiers": [ [ "species_10578461", "catalyst" ] ], "additional_components": [ "Q8TA03", "DDB_G0277885" ] }, "reaction_10624007": { "compartment": "compartment_70101", "id": "reaction_10624007", "reactome": "R-DDI-8955844", "name": "RBKS phosphorylates ribose to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8955853" ], "products": [ "species_73578", "species_29370" ], "modifiers": [ [ "species_10624004", "catalyst" ] ], "additional_components": [ "DDB_G0280893" ] }, "reaction_10578502": { "compartment": "compartment_70101", "id": "reaction_10578502", "reactome": "R-DDI-71334", "name": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29578", "species_29882" ], "products": [ "species_29512", "species_29878" ], "modifiers": [ [ "species_10578499", "catalyst" ] ], "additional_components": [ "Q54UP4", "DDB_G0280909" ] }, "reaction_10587241": { "compartment": "compartment_70101", "id": "reaction_10587241", "reactome": "R-DDI-199803", "name": "xylulose 5-phosphate <=> D-ribulose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29790" ], "products": [ "species_29732" ], "modifiers": [ [ "species_10578481", "catalyst" ] ], "additional_components": [ "Q54YE7", "DDB_G0278275", "species_71067" ] }, "reaction_10582811": { "compartment": "compartment_70101", "id": "reaction_10582811", "reactome": "R-DDI-111215", "name": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73578", "species_110644" ], "products": [ "species_73566", "species_109386" ], "modifiers": [ [ "species_10580455", "catalyst" ], [ "species_29926", "catalyst" ], [ "species_29372", "catalyst" ] ], "additional_components": [ "Q75JN8", "DDB_G0272246", "Q54PA9", "DDB_G0284669", "Q54QU9", "DDB_G0283627" ] }, "reaction_10580462": { "compartment": "compartment_70101", "id": "reaction_10580462", "reactome": "R-DDI-73580", "name": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73578", "species_113592" ], "products": [ "species_73566", "species_76577" ], "modifiers": [ [ "species_10580459", "catalyst" ] ], "additional_components": [ "Q75JN8", "DDB_G0272246", "Q54PA9", "DDB_G0284669", "Q54QU9", "DDB_G0283627" ] }, "reaction_10585872": { "compartment": "compartment_70101", "id": "reaction_10585872", "reactome": "R-DDI-177784", "name": "ribose 5-phosphate <=> D-ribulose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73578" ], "products": [ "species_29732" ], "modifiers": [ [ "species_10578489", "catalyst" ] ], "additional_components": [ "DDB_G0276711" ] }, "reaction_10612693": { "compartment": "compartment_70101", "id": "reaction_10612693", "reactome": "R-DDI-6787329", "name": "PGM2:Mg2+ isomerises R1P to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_112016" ], "products": [ "species_73578" ], "modifiers": [ [ "species_10577654", "catalyst" ] ], "additional_components": [ "Q54UQ2", "DDB_G0280897", "species_29926" ] }, "reaction_10578484": { "compartment": "compartment_70101", "id": "reaction_10578484", "reactome": "R-DDI-71303", "name": "RPE dimers isomerise RU5P to XY5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29732" ], "products": [ "species_29790" ], "modifiers": [ [ "species_10578481", "catalyst" ] ], "additional_components": [ "Q54YE7", "DDB_G0278275", "species_71067" ] }, "reaction_10578454": { "compartment": "compartment_70101", "id": "reaction_10578454", "reactome": "R-DDI-71296", "name": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_31467" ], "products": [ "species_29996" ], "modifiers": [ [ "species_10578451", "catalyst" ] ], "additional_components": [ "DDB_G0292898" ] }, "reaction_10587707": { "compartment": "compartment_70101", "id": "reaction_10587707", "reactome": "R-DDI-203553", "name": "eNOS binds NOSIP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587546", "species_10587703" ], "products": [ "species_10587705" ], "modifiers": [], "additional_components": [ "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "DDB_G0270882", "Q55DU4", "DDB_G0270882", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596" ] }, "reaction_10587771": { "compartment": "compartment_876", "id": "reaction_10587771", "reactome": "R-DDI-203680", "name": "eNOS:NOSIP translocation from caveolae to intracellular compartments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587705" ], "products": [ "species_10587769" ], "modifiers": [], "additional_components": [ "Q55DU4", "DDB_G0270882", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_29870", "Q55DU4", "DDB_G0270882" ] }, "reaction_10578208": { "compartment": "compartment_5460", "id": "reaction_10578208", "reactome": "R-DDI-70982", "name": "Fumarate + H2O <=> (S)-Malate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113588", "species_113521" ], "products": [ "species_113544" ], "modifiers": [ [ "species_10578205", "catalyst" ] ], "additional_components": [ "Q54VA2", "DDB_G0280495" ] }, "reaction_10578755": { "compartment": "compartment_5460", "id": "reaction_10578755", "reactome": "R-DDI-71775", "name": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70958", "species_113548", "species_113525" ], "products": [ "species_29374", "species_113573", "species_113536" ], "modifiers": [ [ "species_10578752", "catalyst" ] ], "additional_components": [ "P36967", "DDB_G0289325", "Q869S7", "DDB_G0274449" ] }, "reaction_10578180": { "compartment": "compartment_5460", "id": "reaction_10578180", "reactome": "R-DDI-70967", "name": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_29938" ], "products": [ "species_113594", "species_113529", "species_29362", "species_29376" ], "modifiers": [ [ "species_10578177", "catalyst" ], [ "species_113581", "catalyst" ] ], "additional_components": [ "species_266099", "Q55BI2", "DDB_G0271344", "Q54B68", "DDB_G0293872" ] }, "reaction_10593319": { "compartment": "compartment_5462", "id": "reaction_10593319", "reactome": "R-DDI-450971", "name": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_113526", "species_113600" ], "products": [ "species_113563", "species_113529", "species_29362" ], "modifiers": [ [ "species_10593316", "catalyst" ] ], "additional_components": [ "Q55F30", "DDB_G0269046" ] }, "reaction_10624580": { "compartment": "compartment_5460", "id": "reaction_10624580", "reactome": "R-DDI-9012016", "name": "FAHD1:Zn2+ dimer hydrolyses OA to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113587" ], "products": [ "species_113557", "species_29376" ], "modifiers": [ [ "species_10624577", "catalyst" ] ], "additional_components": [ "species_29926", "Q86I22", "DDB_G0275071" ] }, "reaction_10593321": { "compartment": "compartment_5460", "id": "reaction_10593321", "reactome": "R-DDI-450975", "name": "isocitrate <=> citrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29938" ], "products": [ "species_29654" ], "modifiers": [ [ "species_10578185", "catalyst" ] ], "additional_components": [ "DDB_G0278779" ] }, "reaction_10578537": { "compartment": "compartment_5460", "id": "reaction_10578537", "reactome": "R-DDI-71401", "name": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113594", "species_113526" ], "products": [ "species_70958", "species_29362", "species_29376" ], "modifiers": [ [ "species_10578297", "catalyst" ] ], "additional_components": [ "CHEBI:17460", "Q869Y7", "DDB_G0275029", "Q54JE4", "DDB_G0288127", "species_8878387", "Q54EW8", "DDB_G0291648", "species_113596" ] }, "reaction_10578252": { "compartment": "compartment_5460", "id": "reaction_10578252", "reactome": "R-DDI-70997", "name": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70958", "species_113548", "species_113581" ], "products": [ "species_29374", "species_113593", "species_113536" ], "modifiers": [ [ "species_10578249", "catalyst" ] ], "additional_components": [ "P36967", "DDB_G0289325", "Q55AI5", "DDB_G0271842" ] }, "reaction_10578198": { "compartment": "compartment_5460", "id": "reaction_10578198", "reactome": "R-DDI-70975", "name": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559", "species_113587", "species_113521" ], "products": [ "species_29374", "species_29654" ], "modifiers": [ [ "species_10578195", "catalyst" ] ], "additional_components": [ "Q553V1", "DDB_G0275311" ] }, "reaction_10624629": { "compartment": "compartment_5460", "id": "reaction_10624629", "reactome": "R-DDI-9012349", "name": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_113544" ], "products": [ "species_113529", "species_113557", "species_113600", "species_29376" ], "modifiers": [ [ "species_10624626", "catalyst" ] ], "additional_components": [ "species_29926", "Q6TU48", "DDB_G0272524" ] }, "reaction_10578237": { "compartment": "compartment_5460", "id": "reaction_10578237", "reactome": "R-DDI-70994", "name": "Succinate <=> Fumarate (with FAD redox reaction on enzyme)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113536" ], "products": [ "species_113588" ], "modifiers": [ [ "species_10578234", "catalyst" ] ], "additional_components": [ "Q8T2T5", "DDB_G0275115", "Q9U3X4", "DDB_G0280535", "species_113596", "Q54YN1", "DDB_G0278157", "Q55CC2", "DDB_G0270120" ] }, "reaction_10624605": { "compartment": "compartment_5460", "id": "reaction_10624605", "reactome": "R-DDI-9012268", "name": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113544", "species_113526" ], "products": [ "species_113529", "species_113557", "species_29362", "species_29376" ], "modifiers": [ [ "species_10624602", "catalyst" ], [ "species_113588", "catalyst" ], [ "species_113593", "inhibitor" ] ], "additional_components": [ "Q6TU48", "DDB_G0272524", "species_29926" ] }, "reaction_10624594": { "compartment": "compartment_70101", "id": "reaction_10624594", "reactome": "R-DDI-9012036", "name": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_198498" ], "products": [ "species_70106", "species_113528", "species_29398", "species_29364" ], "modifiers": [ [ "species_10624591", "catalyst" ] ], "additional_components": [ "species_29926", "Q6TU48", "DDB_G0272524" ] }, "reaction_10612481": { "compartment": "compartment_70101", "id": "reaction_10612481", "reactome": "R-DDI-6783221", "name": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694130" ], "products": [ "species_29708", "species_29450" ], "modifiers": [ [ "species_10612478", "catalyst" ] ], "additional_components": [ "species_29426", "Q54MR1", "DDB_G0285717" ] }, "reaction_10578535": { "compartment": "compartment_5460", "id": "reaction_10578535", "reactome": "R-DDI-71397", "name": "lipo-PDH decarboxylates PYR to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_113557" ], "products": [ "species_113559", "species_29362", "species_29376" ], "modifiers": [ [ "species_10578532", "catalyst" ] ], "additional_components": [ "Q86AD5", "DDB_G0271564", "Q54C70", "DDB_G0292994", "Q86HX0", "DDB_G0276417", "species_8878387", "P36413", "DDB_G0277847", "Q54EW8", "DDB_G0291648", "species_113596" ] }, "reaction_10624632": { "compartment": "compartment_70101", "id": "reaction_10624632", "reactome": "R-DDI-9012374", "name": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398" ], "products": [ "species_9012375" ], "modifiers": [ [ "species_10604611", "catalyst" ] ], "additional_components": [ "DDB_G0271848" ] }, "reaction_10594272": { "compartment": "compartment_70616", "id": "reaction_10594272", "reactome": "R-DDI-880050", "name": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_880013" ], "products": [ "species_113594", "species_31649" ], "modifiers": [ [ "species_10594269", "catalyst" ] ], "additional_components": [ "DDB_G0267656" ] }, "reaction_10594262": { "compartment": "compartment_5460", "id": "reaction_10594262", "reactome": "R-DDI-880007", "name": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_879997" ], "products": [ "species_113594", "species_31649" ], "modifiers": [ [ "species_10594259", "catalyst" ], [ "species_880069", "catalyst" ], [ "species_880067", "catalyst" ], [ "species_113527", "catalyst" ] ], "additional_components": [ "DDB_G0270500" ] }, "reaction_10594264": { "compartment": "compartment_5460", "id": "reaction_10594264", "reactome": "R-DDI-880033", "name": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_880041" ], "products": [ "species_880046", "species_879997" ], "modifiers": [ [ "species_10594251", "catalyst" ] ], "additional_components": [ "DDB_G0290111" ] }, "reaction_10597540": { "compartment": "compartment_5460", "id": "reaction_10597540", "reactome": "R-DDI-1362416", "name": "Frataxin binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113531", "species_10597538" ], "products": [ "species_10597511" ], "modifiers": [], "additional_components": [ "Q54C45", "DDB_G0293246", "Q54X04", "DDB_G0279287", "Q54RP2", "DDB_G0283003", "Q54FN9", "DDB_G0290725", "Q54C45", "DDB_G0293246", "species_71067", "Q54X04", "DDB_G0279287", "Q54RP2", "DDB_G0283003", "Q54FN9", "DDB_G0290725" ] }, "reaction_10600913": { "compartment": "compartment_5460", "id": "reaction_10600913", "reactome": "R-DDI-2395512", "name": "FDXR transfers electrons to FDX1,2 (FDX1L)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597532", "species_10600909" ], "products": [ "species_10600911", "species_113529", "species_10597524" ], "modifiers": [], "additional_components": [ "CHEBI:33737", "Q55GW1", "DDB_G0267486", "species_31649", "Q54KG7", "DDB_G0287353", "Q54KG7", "DDB_G0287353", "species_113596", "Q55GW1", "DDB_G0267486", "CHEBI:33738" ] }, "reaction_10600915": { "compartment": "compartment_5460", "id": "reaction_10600915", "reactome": "R-DDI-2395517", "name": "NADPH transfers electrons to FDXR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600911", "species_113529", "species_113600" ], "products": [ "species_10600909", "species_113563" ], "modifiers": [], "additional_components": [ "Q54KG7", "DDB_G0287353", "species_113596", "species_31649", "Q54KG7", "DDB_G0287353" ] }, "reaction_10622794": { "compartment": "compartment_5460", "id": "reaction_10622794", "reactome": "R-DDI-8878815", "name": "Formation of 4Fe-4S cluster on ISCA1:ISCA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622773", "species_10622785" ], "products": [ "species_10622771", "species_10622787" ], "modifiers": [ [ "species_10622792", "catalyst" ] ], "additional_components": [ "Q555C8", "DDB_G0274657", "CHEBI:33739", "Q54VS1", "DDB_G0280173", "Q54P40", "DDB_G0284809", "DDB_G0274657", "Q54VS1", "DDB_G0280173", "Q54P40", "DDB_G0284809", "CHEBI:49883", "DDB_G0280889" ] }, "reaction_10597535": { "compartment": "compartment_5460", "id": "reaction_10597535", "reactome": "R-DDI-1362408", "name": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_379721", "species_10597511", "species_10597524" ], "products": [ "species_10597532", "species_10597526", "species_379697" ], "modifiers": [ [ "species_10597511", "catalyst" ], [ "species_10597524", "catalyst" ] ], "additional_components": [ "Q54C45", "DDB_G0293246", "species_71067", "Q54X04", "DDB_G0279287", "Q54RP2", "DDB_G0283003", "Q54FN9", "DDB_G0290725", "Q55GW1", "DDB_G0267486", "CHEBI:33738", "CHEBI:33737", "Q55GW1", "DDB_G0267486", "Q54C45", "DDB_G0293246", "Q54X04", "DDB_G0279287", "Q54RP2", "DDB_G0283003", "CHEBI:33739", "Q54FN9", "DDB_G0290725", "Q54C45", "DDB_G0293246", "species_71067", "Q54X04", "DDB_G0279287", "Q54RP2", "DDB_G0283003", "Q54FN9", "DDB_G0290725", "Q55GW1", "DDB_G0267486", "CHEBI:33738" ] }, "reaction_10584066": { "compartment": "compartment_7660", "id": "reaction_10584066", "reactome": "R-DDI-163664", "name": "AMP binds to gamma subunit of AMP kinase heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584060", "species_164121" ], "products": [ "species_10584064" ], "modifiers": [], "additional_components": [ "Q54YF2", "DDB_G0277905", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "species_76577" ] }, "reaction_10593844": { "compartment": "compartment_876", "id": "reaction_10593844", "reactome": "R-DDI-499981", "name": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10593841", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10590676": { "compartment": "compartment_876", "id": "reaction_10590676", "reactome": "R-DDI-399998", "name": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10590673", "catalyst" ] ], "additional_components": [ "species_29438" ] }, "reaction_10592344": { "compartment": "compartment_876", "id": "reaction_10592344", "reactome": "R-DDI-434381", "name": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_400452" ], "products": [ "species_3632881" ], "modifiers": [ [ "species_10592341", "catalyst" ] ], "additional_components": [ "Q9XYS8", "DDB_G0267406", "Q55FQ9", "DDB_G0267440", "Q9BKJ9", "DDB_G0287035" ] }, "reaction_10613507": { "compartment": "compartment_5460", "id": "reaction_10613507", "reactome": "R-DDI-6792572", "name": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611515", "species_10613491" ], "products": [ "species_10611517", "species_10613499" ], "modifiers": [ [ "species_10613504", "catalyst" ] ], "additional_components": [ "DDB_G0287773", "Q54VG0", "DDB_G0280353", "P36413", "DDB_G0277847", "Q86AD5", "DDB_G0271564", "Q54C70", "DDB_G0292994", "Q86HX0", "DDB_G0276417", "species_8878387", "Q54EW8", "DDB_G0291648", "species_113596", "CHEBI:17460", "Q869Y7", "DDB_G0275029", "Q54JE4", "DDB_G0288127", "Q55FN7", "DDB_G0268020", "Q54M22", "DDB_G0286335", "Q54TR7", "DDB_G0281797", "DDB_G0287773", "Q86AD5", "DDB_G0271564", "Q54C70", "DDB_G0292994", "Q86HX0", "DDB_G0276417", "species_8878387", "P36413", "DDB_G0277847", "Q54EW8", "DDB_G0291648", "species_113596", "Q54TR7", "DDB_G0281797", "Q55FN7", "DDB_G0268020", "Q54M22", "DDB_G0286335", "CHEBI:17460", "Q869Y7", "DDB_G0275029", "Q54JE4", "DDB_G0288127", "Q54VG0", "DDB_G0280353", "DDB_G0287107" ] }, "reaction_10590402": { "compartment": "compartment_17951", "id": "reaction_10590402", "reactome": "R-DDI-389821", "name": "glycine + O2 => glyoxylate + H2O2 + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_193446" ], "products": [ "species_389678", "species_389843", "species_113575" ], "modifiers": [ [ "species_10590399", "catalyst" ] ], "additional_components": [ "species_113596", "Q556W1", "DDB_G0273291" ] }, "reaction_10613525": { "compartment": "compartment_5460", "id": "reaction_10613525", "reactome": "R-DDI-6793590", "name": "LIPT2 transfers octanoyl group to GCSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611517", "species_10613514" ], "products": [ "species_10613517", "species_10613512" ], "modifiers": [ [ "species_10613522", "catalyst" ] ], "additional_components": [ "DDB_G0287773", "CHEBI:25650", "Q54E22", "DDB_G0291866", "DDB_G0287773", "DDB_G0291866", "DDB_G0275417" ] }, "reaction_10590342": { "compartment": "compartment_17951", "id": "reaction_10590342", "reactome": "R-DDI-389684", "name": "glyoxylate + alanine => glycine + pyruvate [peroxisome]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389678", "species_389664" ], "products": [ "species_389680", "species_193446" ], "modifiers": [ [ "species_10590339", "catalyst" ] ], "additional_components": [ "Q54GT6", "DDB_G0289923" ] }, "reaction_10590422": { "compartment": "compartment_17951", "id": "reaction_10590422", "reactome": "R-DDI-389842", "name": "HAO1 tetramer oxidizes glycolate to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389822" ], "products": [ "species_389678", "species_113575" ], "modifiers": [ [ "species_10590419", "catalyst" ] ], "additional_components": [ "species_76629", "Q54E41", "DDB_G0291814" ] }, "reaction_10590425": { "compartment": "compartment_17951", "id": "reaction_10590425", "reactome": "R-DDI-389862", "name": "Conversion of glyoxylate to oxalate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_389678" ], "products": [ "species_389819", "species_113575" ], "modifiers": [ [ "species_10590419", "catalyst" ] ], "additional_components": [ "species_76629", "Q54E41", "DDB_G0291814" ] }, "reaction_10612523": { "compartment": "compartment_5460", "id": "reaction_10612523", "reactome": "R-DDI-6784224", "name": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784215" ], "products": [ "species_6784241" ], "modifiers": [ [ "species_10612520", "catalyst" ] ], "additional_components": [ "Q86H28", "DDB_G0275669", "species_113596" ] }, "reaction_10590410": { "compartment": "compartment_17951", "id": "reaction_10590410", "reactome": "R-DDI-389826", "name": "glyoxylate + NADPH + H+ => glycolate + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193465", "species_389678", "species_113602" ], "products": [ "species_389822", "species_389556" ], "modifiers": [ [ "species_10590407", "catalyst" ] ], "additional_components": [ "DDB_G0292104" ] }, "reaction_10617423": { "compartment": "compartment_17951", "id": "reaction_10617423", "reactome": "R-DDI-6810076", "name": "DDO oxidizes D-Asp to OA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_6810061" ], "products": [ "species_113575", "species_389843", "species_6810070" ], "modifiers": [ [ "species_10617420", "catalyst" ] ], "additional_components": [ "species_113596", "Q556W1", "DDB_G0273291" ] }, "reaction_10612526": { "compartment": "compartment_5460", "id": "reaction_10612526", "reactome": "R-DDI-6784393", "name": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784236", "species_113587" ], "products": [ "species_6784229", "species_113553" ], "modifiers": [ [ "species_10577869", "catalyst" ] ], "additional_components": [ "Q55F21", "DDB_G0268664" ] }, "reaction_10600929": { "compartment": "compartment_70101", "id": "reaction_10600929", "reactome": "R-DDI-2408551", "name": "SeMet is converted to AdoSeMet by MAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5357707", "species_113592" ], "products": [ "species_111294", "species_29372", "species_5357652" ], "modifiers": [ [ "species_10585496", "catalyst" ] ], "additional_components": [ "Q54F07", "DDB_G0291179", "species_29926", "species_74126" ] }, "reaction_10624111": { "compartment": "compartment_70101", "id": "reaction_10624111", "reactome": "R-DDI-8959510", "name": "SEPHS2 phosphorylates H2Se to form SELP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5357660", "species_29356", "species_113592" ], "products": [ "species_29372", "species_70106", "species_8959518", "species_76577" ], "modifiers": [ [ "species_10624108", "catalyst" ] ], "additional_components": [ "DDB_G0282367" ] }, "reaction_10595831": { "compartment": "compartment_70101", "id": "reaction_10595831", "reactome": "R-DDI-977333", "name": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_977329", "species_29404" ], "products": [ "species_29406", "species_936706" ], "modifiers": [ [ "species_10595828", "catalyst" ] ], "additional_components": [ "Q55CQ6", "DDB_G0269950" ] }, "reaction_10625019": { "compartment": "compartment_70101", "id": "reaction_10625019", "reactome": "R-DDI-9014741", "name": "PXLP-K56-SRR dimer deaminates D-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_376186" ], "products": [ "species_29356", "species_29382", "species_29398" ], "modifiers": [ [ "species_10625016", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54HH2", "DDB_G0289463" ] }, "reaction_10625800": { "compartment": "compartment_70101", "id": "reaction_10625800", "reactome": "R-DDI-9034539", "name": "PXLP-K56-SRR dimer deaminates L-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_29356", "species_29382", "species_29398" ], "modifiers": [ [ "species_10625016", "catalyst" ] ], "additional_components": [ "Q54HH2", "DDB_G0289463" ] }, "reaction_10625022": { "compartment": "compartment_70101", "id": "reaction_10625022", "reactome": "R-DDI-9014766", "name": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_376186" ], "modifiers": [ [ "species_10625016", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54HH2", "DDB_G0289463" ] }, "reaction_10595820": { "compartment": "compartment_70101", "id": "reaction_10595820", "reactome": "R-DDI-977324", "name": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_936706" ], "products": [ "species_29372", "species_200736" ], "modifiers": [ [ "species_10595817", "catalyst" ] ], "additional_components": [ "Q54ES3", "DDB_G0291368", "species_29926" ] }, "reaction_10622893": { "compartment": "compartment_70101", "id": "reaction_10622893", "reactome": "R-DDI-8932980", "name": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_8932979" ], "modifiers": [ [ "species_10622882", "catalyst" ] ], "additional_components": [ "DDB_G0281099" ] }, "reaction_10585521": { "compartment": "compartment_70101", "id": "reaction_10585521", "reactome": "R-DDI-174401", "name": "AHCY:NAD+ tetramer hydrolyses AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_71285" ], "products": [ "species_83909", "species_174369" ], "modifiers": [ [ "species_10585518", "catalyst" ] ], "additional_components": [ "species_29360", "P10819", "DDB_G0267418" ] }, "reaction_10598480": { "compartment": "compartment_70101", "id": "reaction_10598480", "reactome": "R-DDI-1614583", "name": "PXLP-K212-CTH cleaves L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614518", "species_29356" ], "products": [ "species_111707", "species_29382", "species_936714" ], "modifiers": [ [ "species_10598474", "catalyst" ] ], "additional_components": [ "Q55DV9", "DDB_G0269122" ] }, "reaction_10598454": { "compartment": "compartment_70101", "id": "reaction_10598454", "reactome": "R-DDI-1614524", "name": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736", "species_174369" ], "products": [ "species_1614518", "species_29356" ], "modifiers": [ [ "species_10598451", "catalyst" ] ], "additional_components": [ "species_917877", "P46794", "DDB_G0267386" ] }, "reaction_10585499": { "compartment": "compartment_70101", "id": "reaction_10585499", "reactome": "R-DDI-174391", "name": "MAT1A multimers transfer Ado from ATP to L-Met", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_174390" ], "products": [ "species_111294", "species_29372", "species_71284" ], "modifiers": [ [ "species_10585496", "catalyst" ] ], "additional_components": [ "Q54F07", "DDB_G0291179", "species_29926", "species_74126" ] }, "reaction_10585483": { "compartment": "compartment_70101", "id": "reaction_10585483", "reactome": "R-DDI-174374", "name": "MTR transfers CH3 from MeCbl to HCYS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585476", "species_174369" ], "products": [ "species_10585480", "species_174390" ], "modifiers": [ [ "species_10585476", "catalyst" ] ], "additional_components": [ "Q54P92", "DDB_G0284699", "species_29426", "CHEBI:28115", "species_76629", "Q55G48", "DDB_G0267824", "species_113596", "Q54P92", "DDB_G0284699", "species_29426", "species_3159260", "species_76629", "Q55G48", "DDB_G0267824", "species_113596", "Q54P92", "DDB_G0284699", "species_29426", "CHEBI:28115", "species_76629", "Q55G48", "DDB_G0267824", "species_113596" ] }, "reaction_10597296": { "compartment": "compartment_70101", "id": "reaction_10597296", "reactome": "R-DDI-1237096", "name": "Methylthio-ribose-P = Methylthio-ribulose-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1237165" ], "products": [ "species_1237107" ], "modifiers": [ [ "species_10597293", "catalyst" ] ], "additional_components": [ "DDB_G0283309" ] }, "reaction_10597316": { "compartment": "compartment_70101", "id": "reaction_10597316", "reactome": "R-DDI-1237129", "name": "Acireductone is created", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1237176" ], "products": [ "species_29372", "species_70106", "species_1237155" ], "modifiers": [ [ "species_10597313", "catalyst" ] ], "additional_components": [ "species_29926", "Q55FM6", "DDB_G0268036" ] }, "reaction_10597306": { "compartment": "compartment_70101", "id": "reaction_10597306", "reactome": "R-DDI-1237119", "name": "Acireductone is oxidized to MOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_1237155" ], "products": [ "species_29460", "species_1237122" ], "modifiers": [ [ "species_10597303", "catalyst" ] ], "additional_components": [ "Q54ER6", "DDB_G0291376", "species_71067" ] }, "reaction_10577831": { "compartment": "compartment_70101", "id": "reaction_10577831", "reactome": "R-DDI-70523", "name": "PXLP-K314-GPT transaminates L-Ala to form PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29432" ], "products": [ "species_29404", "species_29398" ], "modifiers": [ [ "species_10577828", "catalyst" ] ], "additional_components": [ "Q54MJ7", "DDB_G0285899" ] }, "reaction_10593878": { "compartment": "compartment_5460", "id": "reaction_10593878", "reactome": "R-DDI-507749", "name": "PXLP-K341-GPT2 transaminates PYR to form L-Ala", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113557", "species_113552" ], "products": [ "species_113594", "species_379697" ], "modifiers": [ [ "species_10593875", "catalyst" ] ], "additional_components": [ "Q54MJ7", "DDB_G0285899" ] }, "reaction_10588674": { "compartment": "compartment_70101", "id": "reaction_10588674", "reactome": "R-DDI-209823", "name": "Tyrosine is hydroxylated to dopa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_29368", "species_29506" ], "products": [ "species_209849", "species_71112" ], "modifiers": [ [ "species_10588671", "catalyst" ] ], "additional_components": [ "species_71067", "Q54XS1", "DDB_G0278781" ] }, "reaction_10611411": { "compartment": "compartment_876", "id": "reaction_10611411", "reactome": "R-DDI-5693681", "name": "DUOX1,2 reduce O2 to H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_351627", "species_352327" ], "products": [ "species_351628", "species_351629" ], "modifiers": [ [ "species_10611408", "catalyst" ] ], "additional_components": [ "Q54F44", "DDB_G0291117", "Q86GL4", "DDB_G0287101", "Q9XYS3", "DDB_G0289653" ] }, "reaction_10589347": { "compartment": "compartment_984", "id": "reaction_10589347", "reactome": "R-DDI-350901", "name": "Iodide is organified", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_351627", "species_209818", "species_351629" ], "products": [ "species_109276", "species_351630", "species_351628" ], "modifiers": [ [ "species_10588619", "catalyst" ] ], "additional_components": [ "DDB_G0277275" ] }, "reaction_10588692": { "compartment": "compartment_984", "id": "reaction_10588692", "reactome": "R-DDI-209925", "name": "DIT and MIT combine to form triiodothyronine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352329", "species_351639" ], "products": [ "species_352331", "species_352036" ], "modifiers": [ [ "species_10588619", "catalyst" ] ], "additional_components": [ "DDB_G0277275" ] }, "reaction_10588694": { "compartment": "compartment_984", "id": "reaction_10588694", "reactome": "R-DDI-209973", "name": "Tyrosine is diiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_351627", "species_352030", "species_209818", "species_351629" ], "products": [ "species_109276", "species_352329", "species_351628" ], "modifiers": [ [ "species_10588619", "catalyst" ] ], "additional_components": [ "DDB_G0277275" ] }, "reaction_10589345": { "compartment": "compartment_70101", "id": "reaction_10589345", "reactome": "R-DDI-350869", "name": "Thyroxine is deiodinated to reverse triiodothyronine (RT3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_209937" ], "products": [ "species_209785", "species_176667", "species_29366" ], "modifiers": [ [ "species_10589342", "catalyst" ] ], "additional_components": [ "DDB_G0275741" ] }, "reaction_10588614": { "compartment": "compartment_70101", "id": "reaction_10588614", "reactome": "R-DDI-209772", "name": "Thyroxine is deiodinated to triiodothyronine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_209937" ], "products": [ "species_209785", "species_176667", "species_29366" ], "modifiers": [ [ "species_10588611", "catalyst" ] ], "additional_components": [ "Q552Y2", "DDB_G0275741" ] }, "reaction_10588685": { "compartment": "compartment_984", "id": "reaction_10588685", "reactome": "R-DDI-209840", "name": "Two DITs combine to form thyroxine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352329" ], "products": [ "species_352326", "species_352036" ], "modifiers": [ [ "species_10588619", "catalyst" ] ], "additional_components": [ "DDB_G0277275" ] }, "reaction_10588622": { "compartment": "compartment_984", "id": "reaction_10588622", "reactome": "R-DDI-209815", "name": "Tyrosine is monoiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351630", "species_352030" ], "products": [ "species_622410", "species_351639" ], "modifiers": [ [ "species_10588619", "catalyst" ] ], "additional_components": [ "DDB_G0277275" ] }, "reaction_10612514": { "compartment": "compartment_70101", "id": "reaction_10612514", "reactome": "R-DDI-6783955", "name": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_35305", "species_29364" ], "products": [ "species_29366", "species_113538" ], "modifiers": [ [ "species_10612511", "catalyst" ] ], "additional_components": [ "Q54IL7", "DDB_G0288671" ] }, "reaction_10577861": { "compartment": "compartment_5460", "id": "reaction_10577861", "reactome": "R-DDI-70589", "name": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_517496", "species_113594", "species_113529", "species_113561" ], "products": [ "species_113552", "species_113521", "species_517495" ], "modifiers": [ [ "species_10577858", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_29364", "species_192305", "species_29360", "species_29366", "Q54KB7", "DDB_G0287469" ] }, "reaction_10594292": { "compartment": "compartment_70101", "id": "reaction_10594292", "reactome": "R-DDI-893616", "name": "glutamine + pyruvate => 2-oxoglutaramate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398", "species_29472" ], "products": [ "species_29432", "species_893598" ], "modifiers": [ [ "species_10594283", "catalyst" ] ], "additional_components": [ "Q54KM6", "DDB_G0287269" ] }, "reaction_10577927": { "compartment": "compartment_5460", "id": "reaction_10577927", "reactome": "R-DDI-70664", "name": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113590", "species_29362" ], "products": [ "species_113526", "species_379717" ], "modifiers": [ [ "species_10577924", "catalyst" ] ], "additional_components": [ "Q54IL7", "DDB_G0288671" ] }, "reaction_10577929": { "compartment": "compartment_5460", "id": "reaction_10577929", "reactome": "R-DDI-70666", "name": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31339", "species_113552" ], "products": [ "species_113594", "species_113585" ], "modifiers": [ [ "species_10577914", "catalyst" ] ], "additional_components": [ "Q54JP5", "DDB_G0287913" ] }, "reaction_10612507": { "compartment": "compartment_5460", "id": "reaction_10612507", "reactome": "R-DDI-6783939", "name": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113590", "species_29362" ], "products": [ "species_113526", "species_379717" ], "modifiers": [ [ "species_10612504", "catalyst" ] ], "additional_components": [ "Q54IL7", "DDB_G0288671" ] }, "reaction_10577884": { "compartment": "compartment_5460", "id": "reaction_10577884", "reactome": "R-DDI-70600", "name": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113552", "species_113521", "species_517495" ], "products": [ "species_517496", "species_113594", "species_113529", "species_113561" ], "modifiers": [ [ "species_10577858", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_29360", "species_29366", "species_29364", "species_192305", "Q54KB7", "DDB_G0287469" ] }, "reaction_10578387": { "compartment": "compartment_70101", "id": "reaction_10578387", "reactome": "R-DDI-71164", "name": "homogentisate + O2 => maleylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_30337" ], "products": [ "species_31135" ], "modifiers": [ [ "species_10578384", "catalyst" ] ], "additional_components": [ "species_71067", "Q54QI4", "DDB_G0283765" ] }, "reaction_10578407": { "compartment": "compartment_70101", "id": "reaction_10578407", "reactome": "R-DDI-71181", "name": "fumarylacetoacetate => fumarate + acetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_31175" ], "products": [ "species_29666", "species_29586" ], "modifiers": [ [ "species_10578404", "catalyst" ] ], "additional_components": [ "Q1ZXQ1", "DDB_G0271094" ] }, "reaction_10578358": { "compartment": "compartment_70101", "id": "reaction_10578358", "reactome": "R-DDI-71155", "name": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29506" ], "products": [ "species_29404", "species_31365" ], "modifiers": [ [ "species_10578355", "catalyst" ] ], "additional_components": [ "Q54K95", "DDB_G0287515" ] }, "reaction_10578377": { "compartment": "compartment_70101", "id": "reaction_10578377", "reactome": "R-DDI-71163", "name": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_31365" ], "products": [ "species_113528", "species_30337" ], "modifiers": [ [ "species_10578374", "catalyst" ] ], "additional_components": [ "Q76NV5", "DDB_G0277511", "Q557J8", "DDB_G0273429", "species_198816", "species_71067" ] }, "reaction_10578397": { "compartment": "compartment_70101", "id": "reaction_10578397", "reactome": "R-DDI-71173", "name": "maleylacetoacetate => fumarylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31135" ], "products": [ "species_31175" ], "modifiers": [ [ "species_10578394", "catalyst" ] ], "additional_components": [ "Q54YN2", "DDB_G0278155", "species_29450" ] }, "reaction_10600401": { "compartment": "compartment_984", "id": "reaction_10600401", "reactome": "R-DDI-2160492", "name": "IL4I1:FAD oxidises L-Phe to kPPV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_351993", "species_352327" ], "products": [ "species_2022135", "species_351629", "species_2160466" ], "modifiers": [ [ "species_10600398", "catalyst" ] ], "additional_components": [ "species_113596", "Q54EW2", "DDB_G0293662", "Q55B17", "DDB_G0293662", "Q54BE7", "DDB_G0293662", "Q55B19", "DDB_G0293662" ] }, "reaction_10578320": { "compartment": "compartment_70101", "id": "reaction_10578320", "reactome": "R-DDI-71118", "name": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_29502", "species_29368" ], "products": [ "species_71112", "species_29506" ], "modifiers": [ [ "species_10578317", "catalyst" ] ], "additional_components": [ "Q54XS1", "DDB_G0278781", "species_71067" ] }, "reaction_10578347": { "compartment": "compartment_70101", "id": "reaction_10578347", "reactome": "R-DDI-71146", "name": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71112" ], "products": [ "species_29356", "species_71129" ], "modifiers": [ [ "species_10578344", "catalyst" ] ], "additional_components": [ "Q54XF6", "DDB_G0278993", "Q54RY8", "DDB_G0282831" ] }, "reaction_10578330": { "compartment": "compartment_70101", "id": "reaction_10578330", "reactome": "R-DDI-71130", "name": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_71129", "species_73473" ], "products": [ "species_29870", "species_29360" ], "modifiers": [ [ "species_10578327", "catalyst" ] ], "additional_components": [ "Q86A17", "DDB_G0272684" ] }, "reaction_10594286": { "compartment": "compartment_70101", "id": "reaction_10594286", "reactome": "R-DDI-893593", "name": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29502", "species_29398" ], "products": [ "species_29432", "species_893599" ], "modifiers": [ [ "species_10594283", "catalyst" ] ], "additional_components": [ "Q54KM6", "DDB_G0287269" ] }, "reaction_10577841": { "compartment": "compartment_5460", "id": "reaction_10577841", "reactome": "R-DDI-70542", "name": "glutamate + acetyl CoA => N-acetyl glutamate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559", "species_113552" ], "products": [ "species_29374", "species_30471" ], "modifiers": [ [ "species_10577838", "catalyst" ], [ "species_374064", "catalyst" ] ], "additional_components": [ "DDB_G0286257" ] }, "reaction_10577906": { "compartment": "compartment_70101", "id": "reaction_10577906", "reactome": "R-DDI-70634", "name": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113567", "species_29498" ], "products": [ "species_113585", "species_29968" ], "modifiers": [ [ "species_10577903", "catalyst" ] ], "additional_components": [ "Q54FE6", "DDB_G0290913", "Q55E85", "DDB_G0269352", "Q86HN8", "DDB_G0274501" ] }, "reaction_10593352": { "compartment": "compartment_5460", "id": "reaction_10593352", "reactome": "R-DDI-452036", "name": "arginine + H2O => ornithine + urea [ARG2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_374064", "species_113521" ], "products": [ "species_374061", "species_113585" ], "modifiers": [ [ "species_10593349", "catalyst" ] ], "additional_components": [ "Q54HV8", "DDB_G0289195", "species_266099" ] }, "reaction_10577851": { "compartment": "compartment_70101", "id": "reaction_10577851", "reactome": "R-DDI-70569", "name": "arginine + H2O => ornithine + urea [ARG1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29468" ], "products": [ "species_29514", "species_29498" ], "modifiers": [ [ "species_10577848", "catalyst" ] ], "additional_components": [ "Q54HV8", "DDB_G0289195", "species_266099" ] }, "reaction_10577872": { "compartment": "compartment_5460", "id": "reaction_10577872", "reactome": "R-DDI-70596", "name": "GOT2 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113553" ], "products": [ "species_113587", "species_113552" ], "modifiers": [ [ "species_10577869", "catalyst" ] ], "additional_components": [ "Q55F21", "DDB_G0268664" ] }, "reaction_10613589": { "compartment": "compartment_70101", "id": "reaction_10613589", "reactome": "R-DDI-6797627", "name": "ASPG hydrolyses L-Asn to L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29642" ], "products": [ "species_29448", "species_29382" ], "modifiers": [ [ "species_10613586", "catalyst" ] ], "additional_components": [ "DDB_G0271924" ] }, "reaction_10577882": { "compartment": "compartment_70101", "id": "reaction_10577882", "reactome": "R-DDI-70599", "name": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_29448", "species_29472" ], "products": [ "species_111294", "species_29404", "species_29642", "species_76577" ], "modifiers": [ [ "species_10577879", "catalyst" ] ], "additional_components": [ "Q54MB4", "DDB_G0286059" ] }, "reaction_10623961": { "compartment": "compartment_5460", "id": "reaction_10623961", "reactome": "R-DDI-8954468", "name": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559", "species_113553" ], "products": [ "species_29374", "species_8954466", "species_113529" ], "modifiers": [ [ "species_10623958", "catalyst" ] ], "additional_components": [ "Q54IG0", "DDB_G0293514", "Q54BP5", "DDB_G0293514" ] }, "reaction_10578417": { "compartment": "compartment_70101", "id": "reaction_10578417", "reactome": "R-DDI-71188", "name": "TDO tetramer dioxygenates L-Trp to NFK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29500", "species_29368" ], "products": [ "species_33179" ], "modifiers": [ [ "species_10578414", "catalyst" ] ], "additional_components": [ "species_917877", "Q55DB4", "DDB_G0269714" ] }, "reaction_10594289": { "compartment": "compartment_70101", "id": "reaction_10594289", "reactome": "R-DDI-893596", "name": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398", "species_29970" ], "products": [ "species_29432", "species_893615" ], "modifiers": [ [ "species_10594283", "catalyst" ], [ "species_29502", "inhibitor" ], [ "species_8939576", "inhibitor" ] ], "additional_components": [ "Q54KM6", "DDB_G0287269", "CHEBI:55528", "CHEBI:43580" ] }, "reaction_10594275": { "compartment": "compartment_5460", "id": "reaction_10594275", "reactome": "R-DDI-893583", "name": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_893607" ], "products": [ "species_893617", "species_113552" ], "modifiers": [ [ "species_10578160", "catalyst" ] ], "additional_components": [ "Q54K00", "DDB_G0287711" ] }, "reaction_10578436": { "compartment": "compartment_70101", "id": "reaction_10578436", "reactome": "R-DDI-71217", "name": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_34351", "species_29356" ], "products": [ "species_29432", "species_30487" ], "modifiers": [ [ "species_10578433", "catalyst" ] ], "additional_components": [ "Q54Q04", "DDB_G0284203" ] }, "reaction_10578425": { "compartment": "compartment_70101", "id": "reaction_10578425", "reactome": "R-DDI-71200", "name": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_29970" ], "products": [ "species_34351", "species_29356", "species_29366" ], "modifiers": [ [ "species_10578422", "catalyst" ] ], "additional_components": [ "DDB_G0283173" ] }, "reaction_10620687": { "compartment": "compartment_876", "id": "reaction_10620687", "reactome": "R-DDI-8870352", "name": "SLC36A4 transports L-Trp from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352006" ], "products": [ "species_29500" ], "modifiers": [ [ "species_10620684", "catalyst" ] ], "additional_components": [ "DDB_G0293074" ] }, "reaction_10578446": { "compartment": "compartment_70101", "id": "reaction_10578446", "reactome": "R-DDI-71218", "name": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_30487" ], "products": [ "species_36027" ], "modifiers": [ [ "species_10578443", "catalyst" ] ], "additional_components": [ "Q54S02", "DDB_G0282743", "species_71067" ] }, "reaction_10606628": { "compartment": "compartment_5668575", "id": "reaction_10606628", "reactome": "R-DDI-5662662", "name": "Tyrosinase oxidises tyrosine to dopaquinone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5668573", "species_5668567" ], "products": [ "species_5668577", "species_5662695" ], "modifiers": [ [ "species_10606620", "catalyst" ], [ "species_10606626", "catalyst" ] ], "additional_components": [ "Q54QT0", "DDB_G0283653", "Q54QT1", "DDB_G0283653", "species_437295", "DDB_G0276801" ] }, "reaction_10606612": { "compartment": "compartment_5668572", "id": "reaction_10606612", "reactome": "R-DDI-5662660", "name": "Dopachrome is transformed to DHICA by DCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5662665" ], "products": [ "species_5662670" ], "modifiers": [ [ "species_10606609", "catalyst" ] ], "additional_components": [ "species_29426", "Q54QT0", "DDB_G0283653", "Q54QT1", "DDB_G0283653" ] }, "reaction_10606631": { "compartment": "compartment_5668572", "id": "reaction_10606631", "reactome": "R-DDI-5662692", "name": "Dopa is oxidized to dopaquinone by TYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5668568", "species_5668566" ], "products": [ "species_5668574", "species_5662695" ], "modifiers": [ [ "species_10606620", "catalyst" ] ], "additional_components": [ "Q54QT0", "DDB_G0283653", "Q54QT1", "DDB_G0283653", "species_437295" ] }, "reaction_10606633": { "compartment": "compartment_5668572", "id": "reaction_10606633", "reactome": "R-DDI-5663050", "name": "DHI and DHICA polymerise forming eumelanin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5662708", "species_5662695" ], "products": [ "species_5668568", "species_5662678" ], "modifiers": [ [ "species_10606620", "catalyst" ] ], "additional_components": [ "species_5662670", "CHEBI:27404", "species_5662670", "CHEBI:27404", "Q54QT0", "DDB_G0283653", "Q54QT1", "DDB_G0283653", "species_437295" ] }, "reaction_10622761": { "compartment": "compartment_5668575", "id": "reaction_10622761", "reactome": "R-DDI-8878581", "name": "TYRP1 oxidises DHICA to IQCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5662670", "species_5668566" ], "products": [ "species_8878586", "species_5668574" ], "modifiers": [ [ "species_10622758", "catalyst" ] ], "additional_components": [ "Q54QT0", "DDB_G0283653", "Q54QT1", "DDB_G0283653" ] }, "reaction_10578017": { "compartment": "compartment_5460", "id": "reaction_10578017", "reactome": "R-DDI-70785", "name": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70772", "species_113521" ], "products": [ "species_70784" ], "modifiers": [ [ "species_10578014", "catalyst" ] ], "additional_components": [ "Q54HG7", "DDB_G0289471" ] }, "reaction_10593920": { "compartment": "compartment_5460", "id": "reaction_10593920", "reactome": "R-DDI-508369", "name": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_70836", "species_29362" ], "products": [ "species_70829", "species_113526" ], "modifiers": [ [ "species_10578034", "catalyst" ] ], "additional_components": [ "Q86JE3", "DDB_G0272128" ] }, "reaction_10593922": { "compartment": "compartment_5460", "id": "reaction_10593922", "reactome": "R-DDI-508473", "name": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_30004", "species_29362" ], "products": [ "species_113526", "species_573404" ], "modifiers": [ [ "species_10578082", "catalyst" ] ], "additional_components": [ "Q54CX6", "DDB_G0292566" ] }, "reaction_10577989": { "compartment": "compartment_70101", "id": "reaction_10577989", "reactome": "R-DDI-70723", "name": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_508182" ], "products": [ "species_29404", "species_508187" ], "modifiers": [ [ "species_10577986", "catalyst" ] ], "additional_components": [ "species_29588", "CHEBI:58045", "CHEBI:57762", "CHEBI:28654", "CHEBI:17865", "CHEBI:16530", "Q54N47", "DDB_G0285509" ] }, "reaction_10578057": { "compartment": "compartment_5460", "id": "reaction_10578057", "reactome": "R-DDI-70859", "name": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70851" ], "products": [ "species_70858", "species_31649" ], "modifiers": [ [ "species_10578054", "catalyst" ] ], "additional_components": [ "Q54IM8", "DDB_G0288647", "species_113596" ] }, "reaction_10578027": { "compartment": "compartment_5460", "id": "reaction_10578027", "reactome": "R-DDI-70800", "name": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70718", "species_113596" ], "products": [ "species_70799", "species_31649" ], "modifiers": [ [ "species_10578024", "catalyst" ] ], "additional_components": [ "Q54RR5", "DDB_G0282967", "species_113596" ] }, "reaction_10577997": { "compartment": "compartment_5460", "id": "reaction_10577997", "reactome": "R-DDI-70724", "name": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_508190" ], "products": [ "species_508181", "species_113552" ], "modifiers": [ [ "species_10577994", "catalyst" ] ], "additional_components": [ "CHEBI:58045", "CHEBI:57762", "species_29588", "CHEBI:16530", "CHEBI:28654", "CHEBI:17865", "Q54N47", "DDB_G0285509" ] }, "reaction_10578093": { "compartment": "compartment_5460", "id": "reaction_10578093", "reactome": "R-DDI-70893", "name": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_30004" ], "products": [ "species_70843", "species_113529", "species_29362", "species_29376" ], "modifiers": [ [ "species_10578090", "catalyst" ] ], "additional_components": [ "DDB_G0289085" ] }, "reaction_10578067": { "compartment": "compartment_5460", "id": "reaction_10578067", "reactome": "R-DDI-70870", "name": "ECHS1 hydrates methacrylyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70858", "species_113521" ], "products": [ "species_71847" ], "modifiers": [ [ "species_10578064", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10578007": { "compartment": "compartment_5460", "id": "reaction_10578007", "reactome": "R-DDI-70745", "name": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70715" ], "products": [ "species_70744", "species_31649" ], "modifiers": [ [ "species_10578004", "catalyst" ] ], "additional_components": [ "Q54W88", "DDB_G0279827", "species_113596" ] }, "reaction_10578075": { "compartment": "compartment_5460", "id": "reaction_10578075", "reactome": "R-DDI-70881", "name": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71847", "species_113521" ], "products": [ "species_29374", "species_573404" ], "modifiers": [ [ "species_10578072", "catalyst" ] ], "additional_components": [ "DDB_G0267536" ] }, "reaction_10577978": { "compartment": "compartment_5460", "id": "reaction_10577978", "reactome": "R-DDI-70713", "name": "BCKDH transfers CoA group from CoA-SH to BCAAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_508181" ], "products": [ "species_29362", "species_508261", "species_29376" ], "modifiers": [ [ "species_10577975", "catalyst" ] ], "additional_components": [ "CHEBI:16530", "CHEBI:28654", "CHEBI:17865", "species_70851", "species_70715", "species_70718", "Q54TR7", "DDB_G0281797", "Q55FN7", "DDB_G0268020", "species_8878387", "Q54M22", "DDB_G0286335", "Q54EW8", "DDB_G0291648", "species_113596" ] }, "reaction_10578047": { "compartment": "compartment_5460", "id": "reaction_10578047", "reactome": "R-DDI-70844", "name": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_70836" ], "products": [ "species_70843", "species_113559" ], "modifiers": [ [ "species_10578044", "catalyst" ] ], "additional_components": [ "Q86AD9", "DDB_G0271544" ] }, "reaction_10589365": { "compartment": "compartment_70101", "id": "reaction_10589365", "reactome": "R-DDI-351215", "name": "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353113", "species_29610" ], "products": [ "species_204635", "species_353106" ], "modifiers": [ [ "species_10589362", "catalyst" ] ], "additional_components": [ "DDB_G0268630" ] }, "reaction_10589355": { "compartment": "compartment_70101", "id": "reaction_10589355", "reactome": "R-DDI-351207", "name": "Spermine => N-acetylated spermine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353560", "species_76183" ], "products": [ "species_76194", "species_353575" ], "modifiers": [ [ "species_10589352", "catalyst" ] ], "additional_components": [ "DDB_G0279851" ] }, "reaction_10589357": { "compartment": "compartment_70101", "id": "reaction_10589357", "reactome": "R-DDI-351208", "name": "Spermidine => N-acetylated spermidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_204635", "species_76183" ], "products": [ "species_353555", "species_76194" ], "modifiers": [ [ "species_10589352", "catalyst" ] ], "additional_components": [ "DDB_G0279851" ] }, "reaction_10577946": { "compartment": "compartment_70101", "id": "reaction_10577946", "reactome": "R-DDI-70692", "name": "ornithine => putrescine + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29498" ], "products": [ "species_29610", "species_113528" ], "modifiers": [ [ "species_10577943", "catalyst" ] ], "additional_components": [ "DDB_G0281109" ] }, "reaction_10589373": { "compartment": "compartment_70101", "id": "reaction_10589373", "reactome": "R-DDI-351222", "name": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284" ], "products": [ "species_353113", "species_113528" ], "modifiers": [ [ "species_10589370", "catalyst" ] ], "additional_components": [ "DDB_G0275567" ] }, "reaction_10578163": { "compartment": "compartment_5460", "id": "reaction_10578163", "reactome": "R-DDI-70952", "name": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_508531" ], "products": [ "species_70951", "species_113552" ], "modifiers": [ [ "species_10578160", "catalyst" ] ], "additional_components": [ "Q54K00", "DDB_G0287711" ] }, "reaction_10612802": { "compartment": "compartment_5460", "id": "reaction_10612802", "reactome": "R-DDI-6788611", "name": "HYKK phosphorylates 5HLYS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788606", "species_113573" ], "products": [ "species_5696409", "species_113525" ], "modifiers": [ [ "species_10612799", "catalyst" ] ], "additional_components": [ "DDB_G0295739" ] }, "reaction_10612500": { "compartment": "compartment_17951", "id": "reaction_10612500", "reactome": "R-DDI-6783880", "name": "PIPOX oxidises PPCA to P6C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_5693325" ], "products": [ "species_113575", "species_6783877" ], "modifiers": [ [ "species_10612497", "catalyst" ] ], "additional_components": [ "DDB_G0280851" ] }, "reaction_10589556": { "compartment": "compartment_5460", "id": "reaction_10589556", "reactome": "R-DDI-372480", "name": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113577" ], "products": [ "species_29406", "species_70951" ], "modifiers": [ [ "species_10589553", "catalyst" ] ], "additional_components": [ "DDB_G0267704" ] }, "reaction_10578310": { "compartment": "compartment_5460", "id": "reaction_10578310", "reactome": "R-DDI-71046", "name": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70955" ], "products": [ "species_71045", "species_31649", "species_29376" ], "modifiers": [ [ "species_10578307", "catalyst" ] ], "additional_components": [ "Q54R47", "DDB_G0283411", "species_113596" ] }, "reaction_10578152": { "compartment": "compartment_5460", "id": "reaction_10578152", "reactome": "R-DDI-70941", "name": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_113556", "species_113521" ], "products": [ "species_113529", "species_508531", "species_29362" ], "modifiers": [ [ "species_10578149", "catalyst" ] ], "additional_components": [ "P83401", "DDB_G0276821" ] }, "reaction_10578139": { "compartment": "compartment_5460", "id": "reaction_10578139", "reactome": "R-DDI-70938", "name": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113529", "species_29444", "species_113600" ], "products": [ "species_113563", "species_113521", "species_30176" ], "modifiers": [ [ "species_10578136", "catalyst" ] ], "additional_components": [ "Q54NG9", "DDB_G0285267" ] }, "reaction_10611324": { "compartment": "compartment_17951", "id": "reaction_10611324", "reactome": "R-DDI-5693347", "name": "CRYM reduces P2C to PPCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193465", "species_5693311", "species_113602" ], "products": [ "species_5693325", "species_389556" ], "modifiers": [ [ "species_10611321", "catalyst" ] ], "additional_components": [ "DDB_G0292894" ] }, "reaction_10578300": { "compartment": "compartment_5460", "id": "reaction_10578300", "reactome": "R-DDI-71037", "name": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_70951" ], "products": [ "species_70955", "species_29362", "species_29376" ], "modifiers": [ [ "species_10578297", "catalyst" ] ], "additional_components": [ "CHEBI:17460", "Q869Y7", "DDB_G0275029", "Q54JE4", "DDB_G0288127", "species_8878387", "Q54EW8", "DDB_G0291648", "species_113596" ] }, "reaction_10578142": { "compartment": "compartment_5460", "id": "reaction_10578142", "reactome": "R-DDI-70940", "name": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_113521", "species_30176" ], "products": [ "species_113529", "species_113556", "species_29362", "species_113552" ], "modifiers": [ [ "species_10578136", "catalyst" ] ], "additional_components": [ "Q54NG9", "DDB_G0285267" ] }, "reaction_10578129": { "compartment": "compartment_70101", "id": "reaction_10578129", "reactome": "R-DDI-70920", "name": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30158", "species_111355" ], "products": [ "species_29404", "species_70919" ], "modifiers": [ [ "species_10578126", "catalyst" ] ], "additional_components": [ "Q54JL3", "DDB_G0287977" ] }, "reaction_10578101": { "compartment": "compartment_70101", "id": "reaction_10578101", "reactome": "R-DDI-70899", "name": "histidine => urocanate + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29612" ], "products": [ "species_31633", "species_30721" ], "modifiers": [ [ "species_10578098", "catalyst" ] ], "additional_components": [ "DDB_G0288025" ] }, "reaction_10578119": { "compartment": "compartment_70101", "id": "reaction_10578119", "reactome": "R-DDI-70906", "name": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_34979" ], "products": [ "species_30158", "species_70106" ], "modifiers": [ [ "species_10578116", "catalyst" ] ], "additional_components": [ "DDB_G0269854" ] }, "reaction_10622372": { "compartment": "compartment_70101", "id": "reaction_10622372", "reactome": "R-DDI-8876789", "name": "CARNMT1 methylates CARN to Anserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6786250", "species_71284" ], "products": [ "species_71285", "species_8876775" ], "modifiers": [ [ "species_10622369", "catalyst" ] ], "additional_components": [ "DDB_G0282239" ] }, "reaction_10578111": { "compartment": "compartment_70101", "id": "reaction_10578111", "reactome": "R-DDI-70903", "name": "urocanate + H2O => 4-imidazolone-5-propionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30721" ], "products": [ "species_34979" ], "modifiers": [ [ "species_10578108", "catalyst" ] ], "additional_components": [ "species_29360", "Q86AX3", "DDB_G0277727" ] }, "reaction_10613621": { "compartment": "compartment_70101", "id": "reaction_10613621", "reactome": "R-DDI-6797956", "name": "SLC44A1 transports Cho from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264618" ], "products": [ "species_6798162" ], "modifiers": [ [ "species_10613618", "catalyst" ] ], "additional_components": [ "Q54IJ2", "DDB_G0288717", "Q54I48", "DDB_G0289013" ] }, "reaction_10613629": { "compartment": "compartment_5460", "id": "reaction_10613629", "reactome": "R-DDI-6797961", "name": "CHDH oxidises Cho to BETALD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_6798162" ], "products": [ "species_6798194", "species_31649" ], "modifiers": [ [ "species_10613626", "catalyst" ] ], "additional_components": [ "DDB_G0287229" ] }, "reaction_10613612": { "compartment": "compartment_5460", "id": "reaction_10613612", "reactome": "R-DDI-6797955", "name": "ALDH7A1 oxidises BETALD to BET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_6798194", "species_113521" ], "products": [ "species_6798202", "species_29362" ], "modifiers": [ [ "species_10578147", "catalyst" ] ], "additional_components": [ "DDB_G0276821" ] }, "reaction_10580773": { "compartment": "compartment_5460", "id": "reaction_10580773", "reactome": "R-DDI-73916", "name": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559" ], "products": [ "species_29374", "species_73871" ], "modifiers": [ [ "species_10578044", "catalyst" ] ], "additional_components": [ "Q86AD9", "DDB_G0271544" ] }, "reaction_10621991": { "compartment": "compartment_5460", "id": "reaction_10621991", "reactome": "R-DDI-8875071", "name": "ACSS3 ligates CoA to CH3COO-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_113539" ], "products": [ "species_159448", "species_159450", "species_113559" ], "modifiers": [ [ "species_10621988", "catalyst" ] ], "additional_components": [ "DDB_G0274939" ] }, "reaction_10580788": { "compartment": "compartment_5460", "id": "reaction_10580788", "reactome": "R-DDI-73918", "name": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73871", "species_113559" ], "products": [ "species_29374", "species_73917" ], "modifiers": [ [ "species_10580785", "catalyst" ] ], "additional_components": [ "P54872", "DDB_G0288461", "Q86HL5", "DDB_G0274871" ] }, "reaction_10581175": { "compartment": "compartment_5460", "id": "reaction_10581175", "reactome": "R-DDI-74180", "name": "HMG CoA => acetoacetic acid + acetyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73917" ], "products": [ "species_113559", "species_73909" ], "modifiers": [ [ "species_10581172", "catalyst" ] ], "additional_components": [ "Q54QI7", "DDB_G0283813" ] }, "reaction_10612794": { "compartment": "compartment_70101", "id": "reaction_10612794", "reactome": "R-DDI-6788597", "name": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191374" ], "products": [ "species_76183", "species_29666" ], "modifiers": [ [ "species_10612791", "catalyst" ] ], "additional_components": [ "Q54QI7", "DDB_G0283813", "species_29926" ] }, "reaction_10581165": { "compartment": "compartment_5460", "id": "reaction_10581165", "reactome": "R-DDI-74177", "name": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70958", "species_73909" ], "products": [ "species_73871", "species_113536" ], "modifiers": [ [ "species_10581162", "catalyst" ] ], "additional_components": [ "Q54JD9", "DDB_G0288105" ] }, "reaction_10600081": { "compartment": "compartment_17957", "id": "reaction_10600081", "reactome": "R-DDI-2046088", "name": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046052", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2046051", "species_162743", "species_159751" ], "modifiers": [ [ "species_10593966", "catalyst" ] ], "additional_components": [ "Q55BY4", "DDB_G0271066", "C7FZW5", "DDB_G0271066" ] }, "reaction_10600112": { "compartment": "compartment_17951", "id": "reaction_10600112", "reactome": "R-DDI-2066778", "name": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_2066767" ], "products": [ "species_2066766" ], "modifiers": [ [ "species_10586623", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10600083": { "compartment": "compartment_17957", "id": "reaction_10600083", "reactome": "R-DDI-2046090", "name": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046057", "species_113601" ], "products": [ "species_113519", "species_2046065", "species_113564", "species_162743", "species_159751" ], "modifiers": [ [ "species_10593964", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10600114": { "compartment": "compartment_17951", "id": "reaction_10600114", "reactome": "R-DDI-2066780", "name": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2066766" ], "products": [ "species_2066762" ], "modifiers": [ [ "species_10586623", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10600116": { "compartment": "compartment_17951", "id": "reaction_10600116", "reactome": "R-DDI-2066787", "name": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_2046047" ], "products": [ "species_113575", "species_2066767" ], "modifiers": [ [ "species_10590470", "catalyst" ] ], "additional_components": [ "Q54GQ6", "DDB_G0289993", "species_113596" ] }, "reaction_10600119": { "compartment": "compartment_17951", "id": "reaction_10600119", "reactome": "R-DDI-2066788", "name": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193514", "species_2066762" ], "products": [ "species_353123", "species_2066765" ], "modifiers": [ [ "species_10590457", "catalyst" ] ], "additional_components": [ "DDB_G0274339" ] }, "reaction_10600093": { "compartment": "compartment_12045", "id": "reaction_10600093", "reactome": "R-DDI-2046100", "name": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046059", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2046057", "species_162743", "species_159751" ], "modifiers": [ [ "species_10593964", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10600076": { "compartment": "compartment_12045", "id": "reaction_10600076", "reactome": "R-DDI-2046085", "name": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211579", "species_2046056", "species_162743" ], "products": [ "species_2046064", "species_2046049", "species_2046062" ], "modifiers": [ [ "species_10600073", "catalyst" ] ], "additional_components": [ "species_29926", "Q54JK0", "DDB_G0288001", "Q55DR6", "DDB_G0269242", "Q1ZXQ4", "DDB_G0269474" ] }, "reaction_10600079": { "compartment": "compartment_17957", "id": "reaction_10600079", "reactome": "R-DDI-2046087", "name": "Translocation of tetracosahexaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046054", "species_211579" ], "products": [ "species_426639", "species_211606", "species_2046047" ], "modifiers": [ [ "species_10590195", "catalyst" ] ], "additional_components": [ "DDB_G0293194" ] }, "reaction_10578260": { "compartment": "compartment_5460", "id": "reaction_10578260", "reactome": "R-DDI-71020", "name": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71019" ], "products": [ "species_71009" ], "modifiers": [ [ "species_10578257", "catalyst" ] ], "additional_components": [ "DDB_G0275181" ] }, "reaction_10578278": { "compartment": "compartment_5460", "id": "reaction_10578278", "reactome": "R-DDI-71031", "name": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70843", "species_113593", "species_29376" ], "products": [ "species_113548", "species_113581", "species_71019" ], "modifiers": [ [ "species_10578275", "catalyst" ] ], "additional_components": [ "Q553S7", "DDB_G0275355", "Q8T131", "DDB_G0276341" ] }, "reaction_10582422": { "compartment": "compartment_5460", "id": "reaction_10582422", "reactome": "R-DDI-77256", "name": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77255", "species_113521" ], "products": [ "species_77252" ], "modifiers": [ [ "species_10578064", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10582424": { "compartment": "compartment_5460", "id": "reaction_10582424", "reactome": "R-DDI-77314", "name": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77313", "species_113521" ], "products": [ "species_77251" ], "modifiers": [ [ "species_10578064", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10582428": { "compartment": "compartment_5460", "id": "reaction_10582428", "reactome": "R-DDI-77333", "name": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77332", "species_113521" ], "products": [ "species_77330" ], "modifiers": [ [ "species_10578064", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10582426": { "compartment": "compartment_5460", "id": "reaction_10582426", "reactome": "R-DDI-77325", "name": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77324", "species_113521" ], "products": [ "species_77322" ], "modifiers": [ [ "species_10578064", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10611862": { "compartment": "compartment_5460", "id": "reaction_10611862", "reactome": "R-DDI-5696004", "name": "ACSF2 ligates CoA-SH to MCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_5690531" ], "products": [ "species_159448", "species_159450", "species_5690542" ], "modifiers": [ [ "species_10611859", "catalyst" ] ], "additional_components": [ "DDB_G0284963" ] }, "reaction_10618485": { "compartment": "compartment_70101", "id": "reaction_10618485", "reactome": "R-DDI-8848250", "name": "ACBD6 binds LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164991", "species_10618481" ], "products": [ "species_10618483" ], "modifiers": [], "additional_components": [ "DDB_G0290237", "Q54GC8", "DDB_G0290237", "species_164991" ] }, "reaction_10622907": { "compartment": "compartment_70616", "id": "reaction_10622907", "reactome": "R-DDI-8933547", "name": "MCAT transfers Mal from Mal-CoA to NDUFAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_977314", "species_10622896" ], "products": [ "species_29374", "species_10622899" ], "modifiers": [ [ "species_10622904", "catalyst" ] ], "additional_components": [ "DDB_G0291866", "DDB_G0291866", "DDB_G0270558" ] }, "reaction_10610781": { "compartment": "compartment_5460", "id": "reaction_10610781", "reactome": "R-DDI-5690066", "name": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690540", "species_113521" ], "products": [ "species_29374", "species_5690519" ], "modifiers": [ [ "species_10610778", "catalyst" ] ], "additional_components": [ "species_164991", "species_5690542", "species_174602", "species_5690531", "Q54LP9", "DDB_G0286507", "Q556W3", "DDB_G0273293" ] }, "reaction_10610767": { "compartment": "compartment_70101", "id": "reaction_10610767", "reactome": "R-DDI-5690043", "name": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5690044" ], "products": [ "species_5690064", "species_76194" ], "modifiers": [ [ "species_10610764", "catalyst" ] ], "additional_components": [ "species_5690542", "species_164991", "species_5690531", "species_174602", "C7G041", "DDB_G0295733" ] }, "reaction_10618476": { "compartment": "compartment_17957", "id": "reaction_10618476", "reactome": "R-DDI-8848246", "name": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848288", "species_10618470" ], "products": [ "species_10618474" ], "modifiers": [], "additional_components": [ "species_164991", "species_5690542", "DDB_G0270658", "Q5FXM5", "DDB_G0270658", "species_164991", "species_5690542" ] }, "reaction_10587345": { "compartment": "compartment_70101", "id": "reaction_10587345", "reactome": "R-DDI-200423", "name": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10587333" ], "products": [ "species_10587340", "species_29370" ], "modifiers": [ [ "species_10587342", "catalyst" ] ], "additional_components": [ "Q54J08", "DDB_G0288387", "species_266099", "Q54J08", "DDB_G0288387", "species_266099", "Q54YF2", "DDB_G0277905", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542" ] }, "reaction_10581624": { "compartment": "compartment_70101", "id": "reaction_10581624", "reactome": "R-DDI-75851", "name": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_113592", "species_76183" ], "products": [ "species_29372", "species_29370", "species_29508" ], "modifiers": [ [ "species_10581621", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "Q54J08", "DDB_G0288387", "species_266099" ] }, "reaction_10622445": { "compartment": "compartment_70101", "id": "reaction_10622445", "reactome": "R-DDI-8876889", "name": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_113592", "species_76183" ], "products": [ "species_29372", "species_29370", "species_29508" ], "modifiers": [ [ "species_10587333", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "Q54J08", "DDB_G0288387", "species_266099" ] }, "reaction_10612737": { "compartment": "compartment_17951", "id": "reaction_10612737", "reactome": "R-DDI-6787811", "name": "HAO2 tetramer oxidises 2OH-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_6787810" ], "products": [ "species_113575", "species_6787814" ], "modifiers": [ [ "species_10612734", "catalyst" ] ], "additional_components": [ "Q54E41", "DDB_G0291814" ] }, "reaction_10590464": { "compartment": "compartment_17951", "id": "reaction_10590464", "reactome": "R-DDI-390252", "name": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_390249" ], "products": [ "species_390248" ], "modifiers": [ [ "species_10586623", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10595810": { "compartment": "compartment_17951", "id": "reaction_10595810", "reactome": "R-DDI-977317", "name": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_977323" ], "products": [ "species_353123", "species_389536" ], "modifiers": [ [ "species_10595807", "catalyst" ] ], "additional_components": [ "DDB_G0290089" ] }, "reaction_10590473": { "compartment": "compartment_17951", "id": "reaction_10590473", "reactome": "R-DDI-390256", "name": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_390260" ], "products": [ "species_390249", "species_113575" ], "modifiers": [ [ "species_10590470", "catalyst" ] ], "additional_components": [ "Q54GQ6", "DDB_G0289993", "species_113596" ] }, "reaction_10617416": { "compartment": "compartment_17951", "id": "reaction_10617416", "reactome": "R-DDI-6809808", "name": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6809801" ], "products": [ "species_6809800" ], "modifiers": [ [ "species_10617413", "catalyst" ] ], "additional_components": [ "Q5FXM5", "DDB_G0270658" ] }, "reaction_10590493": { "compartment": "compartment_17947", "id": "reaction_10590493", "reactome": "R-DDI-390393", "name": "Peroxisomal uptake of very long-chain fatty acyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390394" ], "products": [ "species_390260" ], "modifiers": [ [ "species_10590197", "catalyst" ] ], "additional_components": [ "Q8T8P3", "DDB_G0293194" ] }, "reaction_10590460": { "compartment": "compartment_17951", "id": "reaction_10590460", "reactome": "R-DDI-390250", "name": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193514", "species_390241" ], "products": [ "species_353123", "species_390246" ], "modifiers": [ [ "species_10590457", "catalyst" ] ], "additional_components": [ "DDB_G0274339" ] }, "reaction_10590462": { "compartment": "compartment_17951", "id": "reaction_10590462", "reactome": "R-DDI-390251", "name": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390248", "species_192307" ], "products": [ "species_193465", "species_390241", "species_192305" ], "modifiers": [ [ "species_10586623", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10617487": { "compartment": "compartment_17951", "id": "reaction_10617487", "reactome": "R-DDI-6810474", "name": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_6810523" ], "products": [ "species_6809360", "species_6810530" ], "modifiers": [ [ "species_10617484", "catalyst" ] ], "additional_components": [ "DDB_G0290277" ] }, "reaction_10590323": { "compartment": "compartment_17951", "id": "reaction_10590323", "reactome": "R-DDI-389639", "name": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389615", "species_389537" ], "products": [ "species_389594", "species_389583", "species_389536" ], "modifiers": [ [ "species_10590320", "catalyst" ] ], "additional_components": [ "species_71067", "Q54SF6", "DDB_G0282495" ] }, "reaction_10590313": { "compartment": "compartment_17951", "id": "reaction_10590313", "reactome": "R-DDI-389611", "name": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389594" ], "products": [ "species_389578", "species_389636" ], "modifiers": [ [ "species_10590310", "catalyst" ] ], "additional_components": [ "species_8878387", "species_29926", "Q54DA9", "DDB_G0292402" ] }, "reaction_10590331": { "compartment": "compartment_17947", "id": "reaction_10590331", "reactome": "R-DDI-389652", "name": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_389620" ], "products": [ "species_389573", "species_76577" ], "modifiers": [ [ "species_10590328", "catalyst" ] ], "additional_components": [ "DDB_G0272346" ] }, "reaction_10590301": { "compartment": "compartment_17951", "id": "reaction_10590301", "reactome": "R-DDI-389609", "name": "ALDH3A2-2 oxidizes pristanal to pristanate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389636", "species_192307" ], "products": [ "species_193465", "species_6811612", "species_192305" ], "modifiers": [ [ "species_10590298", "catalyst" ] ], "additional_components": [ "Q54DG1", "DDB_G0292270" ] }, "reaction_10589036": { "compartment": "compartment_70101", "id": "reaction_10589036", "reactome": "R-DDI-265296", "name": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29768" ], "products": [ "species_266010" ], "modifiers": [ [ "species_10589033", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "species_74112", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10600427": { "compartment": "compartment_70101", "id": "reaction_10600427", "reactome": "R-DDI-2161794", "name": "Arachidonic acid is converted to HXA3/B3 by ALOX12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29768" ], "products": [ "species_2162031" ], "modifiers": [ [ "species_10600421", "catalyst" ] ], "additional_components": [ "species_8942209", "CHEBI:34784", "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10600435": { "compartment": "compartment_12045", "id": "reaction_10600435", "reactome": "R-DDI-2161890", "name": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29768", "species_29364" ], "products": [ "species_29356", "species_29366", "species_2142739" ], "modifiers": [ [ "species_10582322", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10600471": { "compartment": "compartment_70101", "id": "reaction_10600471", "reactome": "R-DDI-2161961", "name": "EET(1) is hydrolysed to DHET(1) by EPHX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2161818" ], "products": [ "species_2161883" ], "modifiers": [ [ "species_10600468", "catalyst" ] ], "additional_components": [ "species_2142739", "CHEBI:34130", "CHEBI:34490", "CHEBI:34157", "CHEBI:63974", "CHEBI:63969", "CHEBI:63970", "CHEBI:63966", "Q54T91", "DDB_G0281917", "species_29926" ] }, "reaction_10600440": { "compartment": "compartment_12045", "id": "reaction_10600440", "reactome": "R-DDI-2161899", "name": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29768", "species_29364" ], "products": [ "species_29356", "species_2161753", "species_29366" ], "modifiers": [ [ "species_10600437", "catalyst" ] ], "additional_components": [ "CHEBI:34130", "CHEBI:34490", "CHEBI:34157", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10600432": { "compartment": "compartment_12045", "id": "reaction_10600432", "reactome": "R-DDI-2161814", "name": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2142836" ], "modifiers": [ [ "species_10600429", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10600447": { "compartment": "compartment_12045", "id": "reaction_10600447", "reactome": "R-DDI-2161940", "name": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2142780" ], "modifiers": [ [ "species_10588851", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10589155": { "compartment": "compartment_70101", "id": "reaction_10589155", "reactome": "R-DDI-266072", "name": "LTA4 is hydolysed to LTB4 by LTA4H", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_265281" ], "products": [ "species_266056" ], "modifiers": [ [ "species_10589152", "catalyst" ] ], "additional_components": [ "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10600500": { "compartment": "compartment_70101", "id": "reaction_10600500", "reactome": "R-DDI-2162019", "name": "LTA4 is converted to EXA4 by ALOX15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265281" ], "products": [ "species_2142772" ], "modifiers": [ [ "species_10600479", "catalyst" ] ], "additional_components": [ "species_71067", "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577" ] }, "reaction_10589113": { "compartment": "compartment_70101", "id": "reaction_10589113", "reactome": "R-DDI-266050", "name": "LTA4 is converted to LTC4 by LTC4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_265281" ], "products": [ "species_266066" ], "modifiers": [ [ "species_10589033", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "species_74112", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10589145": { "compartment": "compartment_876", "id": "reaction_10589145", "reactome": "R-DDI-266070", "name": "LTC4 is exported from the cytosol by ABCC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266066" ], "products": [ "species_266013" ], "modifiers": [ [ "species_10589142", "catalyst" ] ], "additional_components": [ "Q54JR2", "DDB_G0287691", "Q54LE6", "DDB_G0286559", "Q8ST87", "DDB_G0280977", "Q54P13", "DDB_G0284867", "Q54U44", "DDB_G0280973" ] }, "reaction_10589115": { "compartment": "compartment_70101", "id": "reaction_10589115", "reactome": "R-DDI-266051", "name": "5S-HpETE is dehydrated to LTA4 by ALOX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266010" ], "products": [ "species_29356", "species_265281" ], "modifiers": [ [ "species_10589033", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "species_74112", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10600410": { "compartment": "compartment_70101", "id": "reaction_10600410", "reactome": "R-DDI-2161768", "name": "EXA4 is converted to EXC4 by LTC4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_2142772" ], "products": [ "species_2142726" ], "modifiers": [ [ "species_10589033", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "species_74112", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10600497": { "compartment": "compartment_70101", "id": "reaction_10600497", "reactome": "R-DDI-2162002", "name": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29768" ], "products": [ "species_2142718" ], "modifiers": [ [ "species_10600494", "catalyst" ] ], "additional_components": [ "species_71067", "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577" ] }, "reaction_10623250": { "compartment": "compartment_70101", "id": "reaction_10623250", "reactome": "R-DDI-8942208", "name": "ALOXE3 isomerises 12R-HpETE to HXA3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142790" ], "products": [ "species_8942209" ], "modifiers": [ [ "species_10623247", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577" ] }, "reaction_10600450": { "compartment": "compartment_70101", "id": "reaction_10600450", "reactome": "R-DDI-2161948", "name": "Arachidonic acid is converted to 12-oxoETE by ALOX12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29768" ], "products": [ "species_2142745" ], "modifiers": [ [ "species_10600421", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10600484": { "compartment": "compartment_70101", "id": "reaction_10600484", "reactome": "R-DDI-2161964", "name": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29768" ], "products": [ "species_2142811" ], "modifiers": [ [ "species_10600481", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10600461": { "compartment": "compartment_70101", "id": "reaction_10600461", "reactome": "R-DDI-2161950", "name": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29768" ], "products": [ "species_2142790" ], "modifiers": [ [ "species_10600458", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577", "species_71067" ] }, "reaction_10594017": { "compartment": "compartment_70101", "id": "reaction_10594017", "reactome": "R-DDI-549192", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_76103" ], "products": [ "species_549167", "species_76194" ], "modifiers": [ [ "species_10594014", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10611920": { "compartment": "compartment_12045", "id": "reaction_10611920", "reactome": "R-DDI-5696119", "name": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_5696122", "species_29368" ], "products": [ "species_29356", "species_1497857", "species_76116", "species_5696116" ], "modifiers": [ [ "species_10611917", "catalyst" ] ], "additional_components": [ "DDB_G0277137" ] }, "reaction_10581764": { "compartment": "compartment_70101", "id": "reaction_10581764", "reactome": "R-DDI-75900", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_76103" ], "products": [ "species_549167", "species_76194" ], "modifiers": [ [ "species_10581761", "catalyst" ] ], "additional_components": [ "Q55BH9", "DDB_G0271342" ] }, "reaction_10581736": { "compartment": "compartment_70101", "id": "reaction_10581736", "reactome": "R-DDI-75887", "name": "Conversion of Glycerol to Glycerol-3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76116" ], "products": [ "species_29370", "species_76114" ], "modifiers": [ [ "species_10581731", "catalyst" ] ], "additional_components": [ "DDB_G0280371" ] }, "reaction_10616072": { "compartment": "compartment_12045", "id": "reaction_10616072", "reactome": "R-DDI-6800334", "name": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6800352", "species_1500578" ], "products": [ "species_76103", "species_76194" ], "modifiers": [ [ "species_10616065", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10581754": { "compartment": "compartment_70101", "id": "reaction_10581754", "reactome": "R-DDI-75899", "name": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76108", "species_29356" ], "products": [ "species_29372", "species_76103" ], "modifiers": [ [ "species_10581751", "catalyst" ] ], "additional_components": [ "Q75JA1", "DDB_G0271730" ] }, "reaction_10625442": { "compartment": "compartment_70101", "id": "reaction_10625442", "reactome": "R-DDI-9018862", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9022655" ], "products": [ "species_9022660" ], "modifiers": [ [ "species_10589152", "catalyst" ] ], "additional_components": [ "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10625439": { "compartment": "compartment_70101", "id": "reaction_10625439", "reactome": "R-DDI-9018859", "name": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9020602" ], "products": [ "species_9022655" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625485": { "compartment": "compartment_70101", "id": "reaction_10625485", "reactome": "R-DDI-9020610", "name": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9020474" ], "products": [ "species_9022679" ], "modifiers": [ [ "species_10600477", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577" ] }, "reaction_10625437": { "compartment": "compartment_70101", "id": "reaction_10625437", "reactome": "R-DDI-9018858", "name": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9020474" ], "products": [ "species_9020602" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625446": { "compartment": "compartment_70101", "id": "reaction_10625446", "reactome": "R-DDI-9018877", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9023708" ], "products": [ "species_9023712" ], "modifiers": [ [ "species_10589152", "catalyst" ] ], "additional_components": [ "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10625444": { "compartment": "compartment_70101", "id": "reaction_10625444", "reactome": "R-DDI-9018863", "name": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023651", "species_29368" ], "products": [ "species_9023702" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625451": { "compartment": "compartment_70101", "id": "reaction_10625451", "reactome": "R-DDI-9018907", "name": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023651", "species_29368" ], "products": [ "species_9023644" ], "modifiers": [ [ "species_10600477", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577" ] }, "reaction_10625448": { "compartment": "compartment_70101", "id": "reaction_10625448", "reactome": "R-DDI-9018894", "name": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023702", "species_29368" ], "products": [ "species_9023708" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625505": { "compartment": "compartment_70101", "id": "reaction_10625505", "reactome": "R-DDI-9025957", "name": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9025155", "species_29368" ], "products": [ "species_9025960" ], "modifiers": [ [ "species_10600421", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10625503": { "compartment": "compartment_70101", "id": "reaction_10625503", "reactome": "R-DDI-9025152", "name": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9025155", "species_29368" ], "products": [ "species_9025151" ], "modifiers": [ [ "species_10600477", "catalyst" ] ], "additional_components": [ "CHEBI:138674", "CHEBI:138673", "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577" ] }, "reaction_10625507": { "compartment": "compartment_70101", "id": "reaction_10625507", "reactome": "R-DDI-9025995", "name": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9026034", "species_29366" ], "products": [ "species_9026050", "species_29364" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625511": { "compartment": "compartment_70101", "id": "reaction_10625511", "reactome": "R-DDI-9025999", "name": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9026047" ], "products": [ "species_9026046", "species_29364" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625509": { "compartment": "compartment_70101", "id": "reaction_10625509", "reactome": "R-DDI-9025996", "name": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9026047" ], "products": [ "species_9026034" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625513": { "compartment": "compartment_70101", "id": "reaction_10625513", "reactome": "R-DDI-9026003", "name": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9608444", "species_29368" ], "products": [ "species_9026047" ], "modifiers": [ [ "species_10600477", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577" ] }, "reaction_10625521": { "compartment": "compartment_70101", "id": "reaction_10625521", "reactome": "R-DDI-9026405", "name": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9026400", "species_29368" ], "products": [ "species_9026394" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "CHEBI:137020", "CHEBI:137011", "CHEBI:137018", "CHEBI:137019", "DDB_G0279909" ] }, "reaction_10625547": { "compartment": "compartment_70101", "id": "reaction_10625547", "reactome": "R-DDI-9027628", "name": "ALOX5 oxidises EPA to 5-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2026977", "species_29368" ], "products": [ "species_9028283" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625545": { "compartment": "compartment_70101", "id": "reaction_10625545", "reactome": "R-DDI-9027624", "name": "ALOX5 oxidises DHA to 7-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024011" ], "products": [ "species_9028274" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625549": { "compartment": "compartment_70101", "id": "reaction_10625549", "reactome": "R-DDI-9027633", "name": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9608444", "species_29368" ], "products": [ "species_9028240" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10600424": { "compartment": "compartment_70101", "id": "reaction_10600424", "reactome": "R-DDI-2161775", "name": "ALOX12 oxidises LTA4 to LXA4/B4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9032038", "species_29368" ], "products": [ "species_2161856" ], "modifiers": [ [ "species_10600421", "catalyst" ] ], "additional_components": [ "CHEBI:6499", "CHEBI:6498", "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10600443": { "compartment": "compartment_70101", "id": "reaction_10600443", "reactome": "R-DDI-2161907", "name": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_2142738" ], "products": [ "species_2161609" ], "modifiers": [ [ "species_10589033", "catalyst" ] ], "additional_components": [ "CHEBI:63991", "CHEBI:63990", "Q54W35", "DDB_G0279909", "species_74112", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10600445": { "compartment": "compartment_70101", "id": "reaction_10600445", "reactome": "R-DDI-2161917", "name": "ALOX5 oxidises 15S-HpETE to LXA4/B4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142718", "species_29368" ], "products": [ "species_2161856" ], "modifiers": [ [ "species_10589033", "catalyst" ] ], "additional_components": [ "CHEBI:6499", "CHEBI:6498", "Q54W35", "DDB_G0279909", "species_74112", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10625475": { "compartment": "compartment_70101", "id": "reaction_10625475", "reactome": "R-DDI-9020274", "name": "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024011" ], "products": [ "species_9025012" ], "modifiers": [ [ "species_10600421", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10625473": { "compartment": "compartment_70101", "id": "reaction_10625473", "reactome": "R-DDI-9020270", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024577" ], "products": [ "species_9024570" ], "modifiers": [ [ "species_10589152", "catalyst" ] ], "additional_components": [ "CHEBI:138615", "CHEBI:138616", "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10625461": { "compartment": "compartment_70101", "id": "reaction_10625461", "reactome": "R-DDI-9020256", "name": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024479" ], "products": [ "species_29364", "species_9024602" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625467": { "compartment": "compartment_70101", "id": "reaction_10625467", "reactome": "R-DDI-9020259", "name": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024463" ], "products": [ "species_9024576" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625481": { "compartment": "compartment_70101", "id": "reaction_10625481", "reactome": "R-DDI-9020278", "name": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024576", "species_29366" ], "products": [ "species_9024577", "species_29364" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625455": { "compartment": "compartment_70101", "id": "reaction_10625455", "reactome": "R-DDI-9020252", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024602" ], "products": [ "species_9024574" ], "modifiers": [ [ "species_10589152", "catalyst" ] ], "additional_components": [ "CHEBI:138179", "CHEBI:138614", "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10625453": { "compartment": "compartment_70101", "id": "reaction_10625453", "reactome": "R-DDI-9020251", "name": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024463" ], "products": [ "species_9024479" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625477": { "compartment": "compartment_70101", "id": "reaction_10625477", "reactome": "R-DDI-9020275", "name": "ALOX15 oxidises DHA to 17(S)-Hp-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024011" ], "products": [ "species_9024012" ], "modifiers": [ [ "species_10600477", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577" ] }, "reaction_10625493": { "compartment": "compartment_70101", "id": "reaction_10625493", "reactome": "R-DDI-9024881", "name": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024012" ], "products": [ "species_29364", "species_9024873" ], "modifiers": [ [ "species_10600477", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577" ] }, "reaction_10625459": { "compartment": "compartment_70101", "id": "reaction_10625459", "reactome": "R-DDI-9020255", "name": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024765" ], "products": [ "species_9024768", "species_29364" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625457": { "compartment": "compartment_70101", "id": "reaction_10625457", "reactome": "R-DDI-9020253", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024781" ], "products": [ "species_9024809" ], "modifiers": [ [ "species_10589152", "catalyst" ] ], "additional_components": [ "CHEBI:138649", "CHEBI:138648", "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10625479": { "compartment": "compartment_70101", "id": "reaction_10625479", "reactome": "R-DDI-9020277", "name": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024797" ], "products": [ "species_29364", "species_9024781" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625483": { "compartment": "compartment_70101", "id": "reaction_10625483", "reactome": "R-DDI-9020282", "name": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024815" ], "products": [ "species_9024765" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625465": { "compartment": "compartment_70101", "id": "reaction_10625465", "reactome": "R-DDI-9020258", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024768" ], "products": [ "species_9024759" ], "modifiers": [ [ "species_10589152", "catalyst" ] ], "additional_components": [ "CHEBI:81565", "CHEBI:81564", "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10625471": { "compartment": "compartment_70101", "id": "reaction_10625471", "reactome": "R-DDI-9020264", "name": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024815" ], "products": [ "species_9024797" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625497": { "compartment": "compartment_70101", "id": "reaction_10625497", "reactome": "R-DDI-9024983", "name": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9025012", "species_29366" ], "products": [ "species_29364", "species_9025001" ], "modifiers": [ [ "species_10600421", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10625538": { "compartment": "compartment_70101", "id": "reaction_10625538", "reactome": "R-DDI-9027043", "name": "CYPs hydroxylate DHA to 14(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_9024011" ], "products": [ "species_29356", "species_29366", "species_9027049" ], "modifiers": [ [ "species_10625535", "catalyst" ] ], "additional_components": [ "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778" ] }, "reaction_10625543": { "compartment": "compartment_70101", "id": "reaction_10625543", "reactome": "R-DDI-9027321", "name": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_9027049" ], "products": [ "species_29356", "species_29366", "species_9027324" ], "modifiers": [ [ "species_10582018", "catalyst" ] ], "additional_components": [ "CHEBI:137368", "CHEBI:137361", "Q1ZXF5", "DDB_G0284535", "Q86A22", "DDB_G0272704", "Q54SK0", "DDB_G0282419", "Q54LA8", "DDB_G0286743", "Q54SV9", "DDB_G0282283", "Q1ZXG3", "DDB_G0282769", "Q54LT7", "DDB_G0286419", "Q1ZXL2", "DDB_G0275197", "Q54ZM4", "DDB_G0277545", "Q54NY3", "DDB_G0284923", "Q556M4", "DDB_G0272604", "Q1ZXL7", "DDB_G0273047", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54CS3", "DDB_G0292792", "Q1ZXA4", "DDB_G0292790", "Q556M5", "DDB_G0273045", "Q54QD0", "DDB_G0283933", "Q55AJ4", "DDB_G0271778", "Q54DT2", "DDB_G0292168", "Q54QD2", "DDB_G0283929", "Q1ZXF3", "DDB_G0284647", "Q54EM5", "DDB_G0291448" ] }, "reaction_10625541": { "compartment": "compartment_70101", "id": "reaction_10625541", "reactome": "R-DDI-9027302", "name": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9027029", "species_70106", "species_29368", "species_29364" ], "products": [ "species_29356", "species_9027326", "species_29366" ], "modifiers": [ [ "species_10582018", "catalyst" ] ], "additional_components": [ "CHEBI:137360", "CHEBI:137354", "Q1ZXF5", "DDB_G0284535", "Q86A22", "DDB_G0272704", "Q54SK0", "DDB_G0282419", "Q54LA8", "DDB_G0286743", "Q54SV9", "DDB_G0282283", "Q1ZXG3", "DDB_G0282769", "Q54LT7", "DDB_G0286419", "Q1ZXL2", "DDB_G0275197", "Q54ZM4", "DDB_G0277545", "Q54NY3", "DDB_G0284923", "Q556M4", "DDB_G0272604", "Q1ZXL7", "DDB_G0273047", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54CS3", "DDB_G0292792", "Q1ZXA4", "DDB_G0292790", "Q556M5", "DDB_G0273045", "Q54QD0", "DDB_G0283933", "Q55AJ4", "DDB_G0271778", "Q54DT2", "DDB_G0292168", "Q54QD2", "DDB_G0283929", "Q1ZXF3", "DDB_G0284647", "Q54EM5", "DDB_G0291448" ] }, "reaction_10625499": { "compartment": "compartment_70101", "id": "reaction_10625499", "reactome": "R-DDI-9024993", "name": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_9025001" ], "products": [ "species_9025011" ], "modifiers": [ [ "species_10600468", "catalyst" ] ], "additional_components": [ "Q54T91", "DDB_G0281917", "species_29926" ] }, "reaction_10625501": { "compartment": "compartment_70101", "id": "reaction_10625501", "reactome": "R-DDI-9024997", "name": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9025012", "species_29368" ], "products": [ "species_9024989" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625533": { "compartment": "compartment_70101", "id": "reaction_10625533", "reactome": "R-DDI-9026911", "name": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9024768" ], "products": [ "species_9026915" ], "modifiers": [ [ "species_10625528", "catalyst" ] ], "additional_components": [ "Q54GA9", "DDB_G0290291" ] }, "reaction_10625524": { "compartment": "compartment_70101", "id": "reaction_10625524", "reactome": "R-DDI-9026777", "name": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9025001" ], "products": [ "species_9026761" ], "modifiers": [ [ "species_10585637", "catalyst" ] ], "additional_components": [ "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q54VI4", "DDB_G0280317", "Q556G3", "DDB_G0272632", "Q556P3", "DDB_G0273153", "Q55FF3", "DDB_G0268138" ] }, "reaction_10625531": { "compartment": "compartment_70101", "id": "reaction_10625531", "reactome": "R-DDI-9026780", "name": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9025001" ], "products": [ "species_9026761" ], "modifiers": [ [ "species_10625528", "catalyst" ] ], "additional_components": [ "Q54GA9", "DDB_G0290291" ] }, "reaction_10625491": { "compartment": "compartment_70101", "id": "reaction_10625491", "reactome": "R-DDI-9024872", "name": "ALOX15 oxidises 17(S)-Hp-DHA to PDX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024012" ], "products": [ "species_9024883" ], "modifiers": [ [ "species_10600477", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577" ] }, "reaction_10625495": { "compartment": "compartment_70101", "id": "reaction_10625495", "reactome": "R-DDI-9024890", "name": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024873" ], "products": [ "species_9024886" ], "modifiers": [ [ "species_10589152", "catalyst" ] ], "additional_components": [ "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10625463": { "compartment": "compartment_70101", "id": "reaction_10625463", "reactome": "R-DDI-9020257", "name": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024893" ], "products": [ "species_9024879" ], "modifiers": [ [ "species_10589152", "catalyst" ] ], "additional_components": [ "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10625469": { "compartment": "compartment_70101", "id": "reaction_10625469", "reactome": "R-DDI-9020262", "name": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024522" ], "products": [ "species_29364", "species_9024893" ], "modifiers": [ [ "species_10600477", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577" ] }, "reaction_10591619": { "compartment": "compartment_70101", "id": "reaction_10591619", "reactome": "R-DDI-428214", "name": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428163" ], "products": [ "species_29370", "species_428275" ], "modifiers": [ [ "species_10591616", "catalyst" ] ], "additional_components": [ "Q6B516", "DDB_G0284545", "Q54HN2", "DDB_G0289343", "Q86KF9", "DDB_G0272522" ] }, "reaction_10591683": { "compartment": "compartment_70101", "id": "reaction_10591683", "reactome": "R-DDI-428676", "name": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203" ], "products": [ "species_428671", "species_428686" ], "modifiers": [ [ "species_10591680", "catalyst" ] ], "additional_components": [ "DDB_G0282819" ] }, "reaction_10611267": { "compartment": "compartment_12045", "id": "reaction_10611267", "reactome": "R-DDI-5692261", "name": "ALDH3A2-1 oxidises HD2NAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428671", "species_29360" ], "products": [ "species_70106", "species_3632881", "species_73473" ], "modifiers": [ [ "species_10611264", "catalyst" ] ], "additional_components": [ "Q54DG1", "DDB_G0292270" ] }, "reaction_10591685": { "compartment": "compartment_70101", "id": "reaction_10591685", "reactome": "R-DDI-428681", "name": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428275" ], "products": [ "species_428686", "species_428663" ], "modifiers": [ [ "species_10591680", "catalyst" ] ], "additional_components": [ "DDB_G0282819" ] }, "reaction_10624103": { "compartment": "compartment_12045", "id": "reaction_10624103", "reactome": "R-DDI-8959462", "name": "SAMD8 transforms PE and CERA to CPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8959490", "species_8959486" ], "products": [ "species_8959463" ], "modifiers": [ [ "species_10624100", "catalyst" ] ], "additional_components": [ "DDB_G0293880" ] }, "reaction_10591627": { "compartment": "compartment_70101", "id": "reaction_10591627", "reactome": "R-DDI-428259", "name": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_428206", "species_428126", "species_29368" ], "products": [ "species_428218", "species_29356", "species_428256" ], "modifiers": [ [ "species_10591624", "catalyst" ] ], "additional_components": [ "species_192305", "species_29364", "species_29360", "species_29366", "DDB_G0269738" ] }, "reaction_10591819": { "compartment": "compartment_876", "id": "reaction_10591819", "reactome": "R-DDI-429786", "name": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429802", "species_429807" ], "products": [ "species_429776", "species_112275" ], "modifiers": [ [ "species_10591816", "catalyst" ] ], "additional_components": [ "DDB_G0293880" ] }, "reaction_10611887": { "compartment": "compartment_876", "id": "reaction_10611887", "reactome": "R-DDI-5696080", "name": "ALDH3B1 oxidises HXAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428663", "species_29360" ], "products": [ "species_70106", "species_3632881", "species_73473" ], "modifiers": [ [ "species_10611884", "catalyst" ] ], "additional_components": [ "DDB_G0292270" ] }, "reaction_10591630": { "compartment": "compartment_70101", "id": "reaction_10591630", "reactome": "R-DDI-428260", "name": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_428126", "species_29368", "species_29364" ], "products": [ "species_29356", "species_29366", "species_9025544" ], "modifiers": [ [ "species_10591624", "catalyst" ] ], "additional_components": [ "DDB_G0269738" ] }, "reaction_10591726": { "compartment": "compartment_70101", "id": "reaction_10591726", "reactome": "R-DDI-428696", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203", "species_29356" ], "products": [ "species_428682", "species_29372" ], "modifiers": [ [ "species_10591723", "catalyst" ] ], "additional_components": [ "Q54PR7", "DDB_G0284367", "Q86AF0", "DDB_G0284367", "Q8MXL9", "DDB_G0284367" ] }, "reaction_10591729": { "compartment": "compartment_70101", "id": "reaction_10591729", "reactome": "R-DDI-428701", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203", "species_29356" ], "products": [ "species_428682", "species_29372" ], "modifiers": [ [ "species_10591669", "catalyst" ] ], "additional_components": [ "DDB_G0272260" ] }, "reaction_10591824": { "compartment": "compartment_20699", "id": "reaction_10591824", "reactome": "R-DDI-429798", "name": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429785", "species_428270" ], "products": [ "species_429773", "species_429789" ], "modifiers": [ [ "species_10591821", "catalyst" ] ], "additional_components": [ "DDB_G0293880" ] }, "reaction_10591600": { "compartment": "compartment_70101", "id": "reaction_10591600", "reactome": "R-DDI-428185", "name": "sphinganine + stearyl-CoA => dihydroceramide + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428139", "species_428163" ], "products": [ "species_428126", "species_76194" ], "modifiers": [ [ "species_10591587", "catalyst" ] ], "additional_components": [ "DDB_G0282607" ] }, "reaction_10616950": { "compartment": "compartment_13977", "id": "reaction_10616950", "reactome": "R-DDI-6808464", "name": "ALDH3B2 oxidises HXAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6808468", "species_29360" ], "products": [ "species_2453691", "species_70106", "species_73473" ], "modifiers": [ [ "species_10616947", "catalyst" ] ], "additional_components": [ "DDB_G0292270" ] }, "reaction_10591638": { "compartment": "compartment_70101", "id": "reaction_10591638", "reactome": "R-DDI-428262", "name": "phytoceramide + H2O => stearate + phytosphingosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9025544" ], "products": [ "species_428237", "species_3632878" ], "modifiers": [ [ "species_10591635", "catalyst" ] ], "additional_components": [ "DDB_G0288359" ] }, "reaction_10591641": { "compartment": "compartment_70101", "id": "reaction_10591641", "reactome": "R-DDI-428273", "name": "SPHK1 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428193" ], "products": [ "species_428203", "species_29370" ], "modifiers": [ [ "species_10590508", "catalyst" ] ], "additional_components": [ "DDB_G0284545" ] }, "reaction_10591705": { "compartment": "compartment_984", "id": "reaction_10591705", "reactome": "R-DDI-428690", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_419305", "species_109276" ], "products": [ "species_109277", "species_428662" ], "modifiers": [ [ "species_10591702", "catalyst" ] ], "additional_components": [ "Q8MXL9", "DDB_G0284367", "Q54PR7", "DDB_G0284367", "Q86AF0", "DDB_G0284367" ] }, "reaction_10591674": { "compartment": "compartment_70101", "id": "reaction_10591674", "reactome": "R-DDI-428664", "name": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428275" ], "products": [ "species_29372", "species_428694" ], "modifiers": [ [ "species_10591669", "catalyst" ] ], "additional_components": [ "DDB_G0272260" ] }, "reaction_10611452": { "compartment": "compartment_12045", "id": "reaction_10611452", "reactome": "R-DDI-5693761", "name": "FA2H hydroxylates CERA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_428256" ], "products": [ "species_5693768", "species_29356" ], "modifiers": [ [ "species_10611449", "catalyst" ] ], "additional_components": [ "DDB_G0269908" ] }, "reaction_10627391": { "compartment": "compartment_70101", "id": "reaction_10627391", "reactome": "R-DDI-9695949", "name": "SPHK2 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428193" ], "products": [ "species_428203", "species_29370" ], "modifiers": [ [ "species_10591614", "catalyst" ], [ "species_10627389", "inhibitor" ] ], "additional_components": [ "Q54HN2", "DDB_G0289343", "Q6B516", "DDB_G0284545", "Q86KF9", "DDB_G0272522", "Q54HN2", "DDB_G0289343", "Q6B516", "DDB_G0284545", "Q86KF9", "DDB_G0272522" ] }, "reaction_10591582": { "compartment": "compartment_70101", "id": "reaction_10591582", "reactome": "R-DDI-428123", "name": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_428182" ], "products": [ "species_29366", "species_428163" ], "modifiers": [ [ "species_10591579", "catalyst" ] ], "additional_components": [ "DDB_G0289061" ] }, "reaction_10586816": { "compartment": "compartment_70101", "id": "reaction_10586816", "reactome": "R-DDI-196761", "name": "2xTPK1:Mg2+ phosphorylates THMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196934" ], "products": [ "species_29480", "species_76577" ], "modifiers": [ [ "species_10586813", "catalyst" ] ], "additional_components": [ "species_29926", "Q55GR8", "DDB_G0267546" ] }, "reaction_10587239": { "compartment": "compartment_876", "id": "reaction_10587239", "reactome": "R-DDI-199626", "name": "SLC19A2/3 transport extracellular THMN to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199622" ], "products": [ "species_196934" ], "modifiers": [ [ "species_10587236", "catalyst" ] ], "additional_components": [ "Q559K0", "DDB_G0272544" ] }, "reaction_10622123": { "compartment": "compartment_17927", "id": "reaction_10622123", "reactome": "R-DDI-8875838", "name": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29480" ], "products": [ "species_8878387" ], "modifiers": [ [ "species_10622120", "catalyst" ] ], "additional_components": [ "DDB_G0280161" ] }, "reaction_10587154": { "compartment": "compartment_876", "id": "reaction_10587154", "reactome": "R-DDI-198818", "name": "SLC2A1,3 transports DeHA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198852" ], "products": [ "species_198827" ], "modifiers": [ [ "species_10587151", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10587173": { "compartment": "compartment_70101", "id": "reaction_10587173", "reactome": "R-DDI-198845", "name": "CYB5A:heme reduces Asc.- to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1497805", "species_10587170" ], "products": [ "species_198816", "species_10587168" ], "modifiers": [ [ "species_10587170", "catalyst" ] ], "additional_components": [ "species_917877", "Q54XT7", "DDB_G0278753", "Q86L22", "DDB_G0277079", "CHEBI:36144", "Q54XT7", "DDB_G0278753", "Q86L22", "DDB_G0277079", "species_917877", "Q54XT7", "DDB_G0278753", "Q86L22", "DDB_G0277079" ] }, "reaction_10587189": { "compartment": "compartment_70101", "id": "reaction_10587189", "reactome": "R-DDI-199202", "name": "Phosphopantetheine conjugation of the ACP domain of FAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587181", "species_76194" ], "products": [ "species_10581670", "species_158466" ], "modifiers": [ [ "species_10587186", "catalyst" ] ], "additional_components": [ "Q55E72", "DDB_G0269364", "Q869W9", "DDB_G0275069", "Q869X2", "DDB_G0275077", "Q869X2", "DDB_G0275077", "Q55E72", "DDB_G0269364", "Q869W9", "DDB_G0275069", "DDB_G0285927" ] }, "reaction_10623045": { "compartment": "compartment_70101", "id": "reaction_10623045", "reactome": "R-DDI-8938300", "name": "Vanin hydrolyses pantetheine to PanK, 2AET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8938313" ], "products": [ "species_196820", "species_6814151" ], "modifiers": [ [ "species_10623042", "catalyst" ] ], "additional_components": [ "Q54WG1", "DDB_G0279675" ] }, "reaction_10586819": { "compartment": "compartment_70101", "id": "reaction_10586819", "reactome": "R-DDI-196773", "name": "COASY phosphorylates DP-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196778" ], "products": [ "species_29370", "species_76194" ], "modifiers": [ [ "species_10586803", "catalyst" ] ], "additional_components": [ "DDB_G0288465" ] }, "reaction_10586806": { "compartment": "compartment_70101", "id": "reaction_10586806", "reactome": "R-DDI-196754", "name": "COASY transfers an adenylyl group from ATP to PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196767", "species_113592" ], "products": [ "species_111294", "species_196778" ], "modifiers": [ [ "species_10586803", "catalyst" ] ], "additional_components": [ "DDB_G0288465" ] }, "reaction_10586829": { "compartment": "compartment_70101", "id": "reaction_10586829", "reactome": "R-DDI-196840", "name": "3xPPCDC:3FMN decarboxylates PPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196834" ], "products": [ "species_196767", "species_113528" ], "modifiers": [ [ "species_10586826", "catalyst" ] ], "additional_components": [ "species_76629", "Q54Y51", "DDB_G0278413" ] }, "reaction_10587197": { "compartment": "compartment_70616", "id": "reaction_10587197", "reactome": "R-DDI-199216", "name": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194" ], "products": [ "species_29374" ], "modifiers": [ [ "species_10587194", "catalyst" ] ], "additional_components": [ "DDB_G0292034" ] }, "reaction_10586798": { "compartment": "compartment_70101", "id": "reaction_10586798", "reactome": "R-DDI-196753", "name": "2xPPCS ligates PPanK with Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_113592", "species_196786" ], "products": [ "species_111294", "species_196834", "species_76577" ], "modifiers": [ [ "species_10586795", "catalyst" ] ], "additional_components": [ "Q54S85", "DDB_G0282611" ] }, "reaction_10595303": { "compartment": "compartment_70101", "id": "reaction_10595303", "reactome": "R-DDI-947499", "name": "Exchange of oxygen with sulfur in MoCo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_947539", "species_111707" ], "products": [ "species_947575", "species_29432" ], "modifiers": [ [ "species_10595300", "catalyst" ] ], "additional_components": [ "DDB_G0272935" ] }, "reaction_10595350": { "compartment": "compartment_70101", "id": "reaction_10595350", "reactome": "R-DDI-947535", "name": "Cyclisation of GTP to precursor Z", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29356", "species_71284" ], "products": [ "species_111294", "species_947537", "species_947703", "species_174390" ], "modifiers": [ [ "species_10595347", "catalyst" ] ], "additional_components": [ "Q54NM6", "DDB_G0285137", "CHEBI:33722" ] }, "reaction_10595338": { "compartment": "compartment_70101", "id": "reaction_10595338", "reactome": "R-DDI-947531", "name": "Molybdenum ion transfer onto molybdopterin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_947561", "species_947496" ], "products": [ "species_111294", "species_947539", "species_76577" ], "modifiers": [ [ "species_10595335", "catalyst" ] ], "additional_components": [ "Q54KM0", "DDB_G0287261", "species_29926" ] }, "reaction_10595326": { "compartment": "compartment_70101", "id": "reaction_10595326", "reactome": "R-DDI-947514", "name": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10595310", "species_111707" ], "products": [ "species_29432", "species_10595315" ], "modifiers": [ [ "species_10595323", "catalyst" ] ], "additional_components": [ "species_29426", "Q55FS0", "DDB_G0267980", "Q55FS0", "DDB_G0267980", "species_29426", "Q54X04", "DDB_G0279287" ] }, "reaction_10595424": { "compartment": "compartment_70101", "id": "reaction_10595424", "reactome": "R-DDI-964970", "name": "2xPDXK:2xZn2+ phosphorylates PXL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_965131" ], "products": [ "species_29390", "species_29370" ], "modifiers": [ [ "species_10595417", "catalyst" ] ], "additional_components": [ "species_29426", "Q55EK9", "DDB_G0268628" ] }, "reaction_10602082": { "compartment": "compartment_70101", "id": "reaction_10602082", "reactome": "R-DDI-3204311", "name": "AOX1 oxidises PXL to PDXate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29368", "species_965131" ], "products": [ "species_3204324", "species_29408" ], "modifiers": [ [ "species_10602079", "catalyst" ] ], "additional_components": [ "CHEBI:33722", "CHEBI:44074", "species_113596", "Q54FB7", "DDB_G0291047" ] }, "reaction_10595434": { "compartment": "compartment_70101", "id": "reaction_10595434", "reactome": "R-DDI-965019", "name": "2xPNPO:2xFMN oxidizes PDXP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_964952" ], "products": [ "species_29390", "species_29408" ], "modifiers": [ [ "species_10595431", "catalyst" ] ], "additional_components": [ "Q54YS6", "DDB_G0278107", "species_76629" ] }, "reaction_10595420": { "compartment": "compartment_70101", "id": "reaction_10595420", "reactome": "R-DDI-964958", "name": "2xPDXK:2xZn2+ phosphorylates PXA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964945", "species_113592" ], "products": [ "species_29370", "species_965146" ], "modifiers": [ [ "species_10595417", "catalyst" ] ], "additional_components": [ "species_29426", "Q55EK9", "DDB_G0268628" ] }, "reaction_10595436": { "compartment": "compartment_70101", "id": "reaction_10595436", "reactome": "R-DDI-965079", "name": "2xPNPO:2xFMN oxidizes PXAP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29368", "species_965146" ], "products": [ "species_29390", "species_31633", "species_29408" ], "modifiers": [ [ "species_10595431", "catalyst" ] ], "additional_components": [ "Q54YS6", "DDB_G0278107", "species_76629" ] }, "reaction_10595422": { "compartment": "compartment_70101", "id": "reaction_10595422", "reactome": "R-DDI-964962", "name": "2xPDKX:2xZn2+ phosphorylates PDX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_965053" ], "products": [ "species_29370", "species_964952" ], "modifiers": [ [ "species_10595417", "catalyst" ] ], "additional_components": [ "species_29426", "Q55EK9", "DDB_G0268628" ] }, "reaction_10603568": { "compartment": "compartment_5460", "id": "reaction_10603568", "reactome": "R-DDI-4167509", "name": "Mitochondrial BTD hydrolyses BCTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3065953" ], "products": [ "species_29582", "species_29444" ], "modifiers": [ [ "species_10603565", "catalyst" ] ], "additional_components": [ "DDB_G0279675" ] }, "reaction_10603574": { "compartment": "compartment_70101", "id": "reaction_10603574", "reactome": "R-DDI-4167511", "name": "HLCS biotinylates ACACB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10603572", "species_199207" ], "products": [ "species_111294", "species_10587331", "species_76577" ], "modifiers": [ [ "species_10601704", "catalyst" ] ], "additional_components": [ "Q54J08", "DDB_G0288387", "species_266099", "Q54J08", "DDB_G0288387", "species_266099", "DDB_G0288791" ] }, "reaction_10601752": { "compartment": "compartment_70101", "id": "reaction_10601752", "reactome": "R-DDI-2993814", "name": "HLCS biotinylates ACACA:Mn2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10601750", "species_199207" ], "products": [ "species_111294", "species_10581619", "species_76577" ], "modifiers": [ [ "species_10601704", "catalyst" ] ], "additional_components": [ "Q54J08", "DDB_G0288387", "species_266099", "Q54J08", "DDB_G0288387", "species_266099", "DDB_G0288791" ] }, "reaction_10601707": { "compartment": "compartment_70101", "id": "reaction_10601707", "reactome": "R-DDI-2993447", "name": "HLCS biotinylates 6x(PCCA:PCCB)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601693", "species_113592", "species_199207" ], "products": [ "species_111294", "species_10601699", "species_76577" ], "modifiers": [ [ "species_10601704", "catalyst" ] ], "additional_components": [ "Q8T131", "DDB_G0276341", "Q553S7", "DDB_G0275355", "Q8T131", "DDB_G0276341", "Q553S7", "DDB_G0275355", "DDB_G0288791" ] }, "reaction_10602666": { "compartment": "compartment_70101", "id": "reaction_10602666", "reactome": "R-DDI-3323111", "name": "Cytoslic carboxylases translocate to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601699" ], "products": [ "species_10578275" ], "modifiers": [], "additional_components": [ "Q8T131", "DDB_G0276341", "Q553S7", "DDB_G0275355", "Q553S7", "DDB_G0275355", "Q8T131", "DDB_G0276341" ] }, "reaction_10601951": { "compartment": "compartment_984", "id": "reaction_10601951", "reactome": "R-DDI-3076905", "name": "Extracellular BTD hydrolyses BCTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3076887" ], "products": [ "species_199238", "species_351991" ], "modifiers": [ [ "species_10601948", "catalyst" ] ], "additional_components": [ "DDB_G0279675" ] }, "reaction_10586913": { "compartment": "compartment_70101", "id": "reaction_10586913", "reactome": "R-DDI-197972", "name": "DHF is reduced to tetrahydrofolate (THF)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73604", "species_29364" ], "products": [ "species_111355", "species_29366" ], "modifiers": [ [ "species_10586908", "catalyst" ] ], "additional_components": [ "DDB_G0286755" ] }, "reaction_10616513": { "compartment": "compartment_5460", "id": "reaction_10616513", "reactome": "R-DDI-6801456", "name": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113581", "species_5389850" ], "products": [ "species_200671", "species_6801451", "species_113593" ], "modifiers": [ [ "species_10612187", "catalyst" ] ], "additional_components": [ "Q54RI8", "DDB_G0283121", "Q54VK0", "DDB_G0283121" ] }, "reaction_10616966": { "compartment": "compartment_5460", "id": "reaction_10616966", "reactome": "R-DDI-6808487", "name": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_6808499", "species_113521" ], "products": [ "species_113529", "species_200679", "species_113600", "species_29376" ], "modifiers": [ [ "species_10616963", "catalyst" ] ], "additional_components": [ "Q54FY1", "DDB_G0290537", "Q54FY3", "DDB_G0290479", "Q54FY2", "DDB_G0290537" ] }, "reaction_10616516": { "compartment": "compartment_5460", "id": "reaction_10616516", "reactome": "R-DDI-6801462", "name": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6801458", "species_113521" ], "products": [ "species_5389850" ], "modifiers": [ [ "species_10616508", "catalyst" ] ], "additional_components": [ "Q54RI8", "DDB_G0283121", "Q54VK0", "DDB_G0283121" ] }, "reaction_10587398": { "compartment": "compartment_70616", "id": "reaction_10587398", "reactome": "R-DDI-200680", "name": "SLC25A32 transports THF from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111355" ], "products": [ "species_200671" ], "modifiers": [ [ "species_10587395", "catalyst" ] ], "additional_components": [ "DDB_G0271922" ] }, "reaction_10587400": { "compartment": "compartment_70101", "id": "reaction_10587400", "reactome": "R-DDI-200681", "name": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_200665", "species_113592" ], "products": [ "species_29372", "species_29370", "species_174404" ], "modifiers": [ [ "species_10586900", "catalyst" ] ], "additional_components": [ "DDB_G0292632" ] }, "reaction_10587405": { "compartment": "compartment_5460", "id": "reaction_10587405", "reactome": "R-DDI-200682", "name": "Mitochondrial FPGS-1 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200671", "species_113593", "species_113552" ], "products": [ "species_113548", "species_113581", "species_200679" ], "modifiers": [ [ "species_10587402", "catalyst" ] ], "additional_components": [ "DDB_G0292632" ] }, "reaction_10587372": { "compartment": "compartment_70101", "id": "reaction_10587372", "reactome": "R-DDI-200644", "name": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_200739" ], "products": [ "species_70106", "species_29364", "species_200640" ], "modifiers": [ [ "species_10587369", "catalyst" ] ], "additional_components": [ "Q54RI8", "DDB_G0283121" ] }, "reaction_10587377": { "compartment": "compartment_876", "id": "reaction_10587377", "reactome": "R-DDI-200652", "name": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200709" ], "products": [ "species_200665" ], "modifiers": [ [ "species_10587374", "catalyst" ] ], "additional_components": [ "DDB_G0272544" ] }, "reaction_10587408": { "compartment": "compartment_70101", "id": "reaction_10587408", "reactome": "R-DDI-200711", "name": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29460", "species_197969" ], "products": [ "species_29372", "species_29370", "species_111353" ], "modifiers": [ [ "species_10587369", "catalyst" ] ], "additional_components": [ "Q54RI8", "DDB_G0283121" ] }, "reaction_10587410": { "compartment": "compartment_70101", "id": "reaction_10587410", "reactome": "R-DDI-200718", "name": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200640" ], "products": [ "species_29366", "species_200739" ], "modifiers": [ [ "species_10587369", "catalyst" ] ], "additional_components": [ "Q54RI8", "DDB_G0283121" ] }, "reaction_10616982": { "compartment": "compartment_70101", "id": "reaction_10616982", "reactome": "R-DDI-6808496", "name": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111353", "species_29366" ], "products": [ "species_70106", "species_113528", "species_29364", "species_197969" ], "modifiers": [ [ "species_10616979", "catalyst" ] ], "additional_components": [ "Q54FY1", "DDB_G0290537", "Q54FY3", "DDB_G0290479", "Q54FY2", "DDB_G0290537" ] }, "reaction_10587380": { "compartment": "compartment_70101", "id": "reaction_10587380", "reactome": "R-DDI-200661", "name": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111353" ], "products": [ "species_29356", "species_200640" ], "modifiers": [ [ "species_10587369", "catalyst" ] ], "additional_components": [ "Q54RI8", "DDB_G0283121" ] }, "reaction_10586903": { "compartment": "compartment_70101", "id": "reaction_10586903", "reactome": "R-DDI-197958", "name": "FPGS-2 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_111355", "species_113592" ], "products": [ "species_29372", "species_29370", "species_197969" ], "modifiers": [ [ "species_10586900", "catalyst" ] ], "additional_components": [ "DDB_G0292632" ] }, "reaction_10587414": { "compartment": "compartment_70101", "id": "reaction_10587414", "reactome": "R-DDI-200740", "name": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_200640" ], "products": [ "species_111353" ], "modifiers": [ [ "species_10587369", "catalyst" ] ], "additional_components": [ "Q54RI8", "DDB_G0283121" ] }, "reaction_10627480": { "compartment": "compartment_70101", "id": "reaction_10627480", "reactome": "R-DDI-9709098", "name": "DHFR dimer reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197965", "species_70106", "species_29364" ], "products": [ "species_29366", "species_73604" ], "modifiers": [ [ "species_10627477", "catalyst" ] ], "additional_components": [ "Q54LA0", "DDB_G0286755" ] }, "reaction_10586911": { "compartment": "compartment_70101", "id": "reaction_10586911", "reactome": "R-DDI-197963", "name": "DHFR2 reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197965", "species_70106", "species_29364" ], "products": [ "species_29366", "species_73604" ], "modifiers": [ [ "species_10586908", "catalyst" ] ], "additional_components": [ "DDB_G0286755" ] }, "reaction_10616511": { "compartment": "compartment_5460", "id": "reaction_10616511", "reactome": "R-DDI-6801328", "name": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_5693984" ], "products": [ "species_6801458", "species_29362" ], "modifiers": [ [ "species_10616508", "catalyst" ] ], "additional_components": [ "Q54RI8", "DDB_G0283121", "Q54VK0", "DDB_G0283121" ] }, "reaction_10612190": { "compartment": "compartment_5460", "id": "reaction_10612190", "reactome": "R-DDI-5696839", "name": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6801451", "species_200671", "species_113593" ], "products": [ "species_113548", "species_113581", "species_5389850" ], "modifiers": [ [ "species_10612187", "catalyst" ] ], "additional_components": [ "Q54RI8", "DDB_G0283121", "Q54VK0", "DDB_G0283121" ] }, "reaction_10587390": { "compartment": "compartment_70101", "id": "reaction_10587390", "reactome": "R-DDI-200676", "name": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200739" ], "products": [ "species_29366", "species_174404" ], "modifiers": [ [ "species_10587387", "catalyst" ] ], "additional_components": [ "Q54X84", "DDB_G0279137" ] }, "reaction_10601859": { "compartment": "compartment_70101", "id": "reaction_10601859", "reactome": "R-DDI-3000238", "name": "LMBRD1 transports lysosomal Cbl to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3000239" ], "products": [ "species_3000241" ], "modifiers": [ [ "species_10601856", "catalyst" ] ], "additional_components": [ "DDB_G0287405" ] }, "reaction_10602051": { "compartment": "compartment_70101", "id": "reaction_10602051", "reactome": "R-DDI-3149518", "name": "MTRR reduces cob(II)alamin to meCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_71284", "species_29364", "species_10602048" ], "products": [ "species_29366", "species_10585476", "species_71285" ], "modifiers": [ [ "species_10602048", "catalyst" ] ], "additional_components": [ "species_3149479", "species_76629", "Q55G48", "DDB_G0267824", "species_113596", "Q54P92", "DDB_G0284699", "species_29426", "Q54P92", "DDB_G0284699", "species_29426", "CHEBI:28115", "species_76629", "Q55G48", "DDB_G0267824", "species_113596", "species_3149479", "species_76629", "Q55G48", "DDB_G0267824", "species_113596", "Q54P92", "DDB_G0284699", "species_29426" ] }, "reaction_10602067": { "compartment": "compartment_5460", "id": "reaction_10602067", "reactome": "R-DDI-3159253", "name": "MMAB transfers adenosyl group from ATP to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3159260", "species_113593" ], "products": [ "species_3159274", "species_3159297" ], "modifiers": [ [ "species_10602064", "catalyst" ] ], "additional_components": [ "Q54W51", "DDB_G0279905" ] }, "reaction_10602084": { "compartment": "compartment_70101", "id": "reaction_10602084", "reactome": "R-DDI-3204318", "name": "cob(II)alamin binds to MTRR:MTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602046", "species_3149479" ], "products": [ "species_10602048" ], "modifiers": [], "additional_components": [ "species_76629", "Q55G48", "DDB_G0267824", "species_113596", "Q54P92", "DDB_G0284699", "species_29426", "species_3149479", "species_76629", "Q55G48", "DDB_G0267824", "species_113596", "Q54P92", "DDB_G0284699", "species_29426" ] }, "reaction_10602054": { "compartment": "compartment_70101", "id": "reaction_10602054", "reactome": "R-DDI-3149519", "name": "MMACHC decyanates CNCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_10601956", "species_29364", "species_3149505" ], "products": [ "species_10601958", "species_29366", "species_1130611" ], "modifiers": [ [ "species_10601956", "catalyst" ] ], "additional_components": [ "DDB_G0274205", "Q86KB5", "DDB_G0274205", "species_3149479", "DDB_G0274205" ] }, "reaction_10601961": { "compartment": "compartment_70101", "id": "reaction_10601961", "reactome": "R-DDI-3095889", "name": "MMACHC reduces Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3000241", "species_70106", "species_10601956", "species_29364" ], "products": [ "species_10601958", "species_29366" ], "modifiers": [ [ "species_10601956", "catalyst" ] ], "additional_components": [ "DDB_G0274205", "Q86KB5", "DDB_G0274205", "species_3149479", "DDB_G0274205" ] }, "reaction_10602057": { "compartment": "compartment_70101", "id": "reaction_10602057", "reactome": "R-DDI-3149539", "name": "MTR transfers CH3 group from MTHF to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200665", "species_10585480" ], "products": [ "species_111355", "species_10585476" ], "modifiers": [ [ "species_10585480", "catalyst" ] ], "additional_components": [ "Q54P92", "DDB_G0284699", "species_29426", "species_3159260", "species_76629", "Q55G48", "DDB_G0267824", "species_113596", "Q54P92", "DDB_G0284699", "species_29426", "CHEBI:28115", "species_76629", "Q55G48", "DDB_G0267824", "species_113596", "Q54P92", "DDB_G0284699", "species_29426", "species_3159260", "species_76629", "Q55G48", "DDB_G0267824", "species_113596" ] }, "reaction_10604780": { "compartment": "compartment_70101", "id": "reaction_10604780", "reactome": "R-DDI-5223313", "name": "ABCD4 may transport Cbl from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_3000239" ], "products": [ "species_29372", "species_3000241", "species_29370" ], "modifiers": [ [ "species_10604777", "catalyst" ] ], "additional_components": [ "DDB_G0279919" ] }, "reaction_10601964": { "compartment": "compartment_70101", "id": "reaction_10601964", "reactome": "R-DDI-3095901", "name": "ABCC1 transports cytosolic Cbl to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_3000241", "species_113592" ], "products": [ "species_29372", "species_29370", "species_3000125" ], "modifiers": [ [ "species_10589142", "catalyst" ] ], "additional_components": [ "Q54JR2", "DDB_G0287691", "Q54LE6", "DDB_G0286559", "Q8ST87", "DDB_G0280977", "Q54P13", "DDB_G0284867", "Q54U44", "DDB_G0280973" ] }, "reaction_10620675": { "compartment": "compartment_70101", "id": "reaction_10620675", "reactome": "R-DDI-8869627", "name": "NMRK2 phosphorylates NR to yield NMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869377" ], "products": [ "species_8869353", "species_70106", "species_29370" ], "modifiers": [ [ "species_10620669", "catalyst" ] ], "additional_components": [ "Q8T154", "DDB_G0274559", "Q55EL3", "DDB_G0269034" ] }, "reaction_10620672": { "compartment": "compartment_70101", "id": "reaction_10620672", "reactome": "R-DDI-8869607", "name": "NMRK2 phosphorylates NAR to yield NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869365" ], "products": [ "species_70106", "species_29370", "species_197220" ], "modifiers": [ [ "species_10620669", "catalyst" ] ], "additional_components": [ "Q8T154", "DDB_G0274559", "Q55EL3", "DDB_G0269034" ] }, "reaction_10586867": { "compartment": "compartment_70101", "id": "reaction_10586867", "reactome": "R-DDI-197198", "name": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29360" ], "products": [ "species_29370", "species_29366" ], "modifiers": [ [ "species_10586864", "catalyst" ] ], "additional_components": [ "species_29426", "Q54D76", "DDB_G0292442" ] }, "reaction_10586885": { "compartment": "compartment_70101", "id": "reaction_10586885", "reactome": "R-DDI-197268", "name": "QPRT transfers PRIB to QUIN to form NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_70106", "species_197238" ], "products": [ "species_111294", "species_113528", "species_197220" ], "modifiers": [ [ "species_10586882", "catalyst" ] ], "additional_components": [ "DDB_G0272462" ] }, "reaction_10620678": { "compartment": "compartment_70101", "id": "reaction_10620678", "reactome": "R-DDI-8869633", "name": "NMRK1 phosphorylates NR to yield NMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869377" ], "products": [ "species_8869353", "species_70106", "species_29370" ], "modifiers": [ [ "species_10620660", "catalyst" ] ], "additional_components": [ "Q8T154", "DDB_G0274559", "Q55EL3", "DDB_G0269034" ] }, "reaction_10616677": { "compartment": "compartment_5460", "id": "reaction_10616677", "reactome": "R-DDI-6806967", "name": "CARKD dehydrates S-NAD(P)HX to NADPH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_6807477" ], "products": [ "species_113548", "species_113581", "species_113529", "species_113600" ], "modifiers": [ [ "species_10616674", "catalyst" ] ], "additional_components": [ "DDB_G0290799" ] }, "reaction_10586857": { "compartment": "compartment_70101", "id": "reaction_10586857", "reactome": "R-DDI-197186", "name": "NAPRT1 dimer transfers PRIB to NCA to form NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_197230", "species_70106" ], "products": [ "species_111294", "species_197220" ], "modifiers": [ [ "species_10586854", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q55G10", "DDB_G0268472" ] }, "reaction_10617321": { "compartment": "compartment_17951", "id": "reaction_10617321", "reactome": "R-DDI-6809287", "name": "NUDT12 hydrolyses NADH to NMNH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_192305", "species_389620" ], "products": [ "species_6809289", "species_193465" ], "modifiers": [ [ "species_10617318", "catalyst" ] ], "additional_components": [ "DDB_G0272048" ] }, "reaction_10623038": { "compartment": "compartment_70101", "id": "reaction_10623038", "reactome": "R-DDI-8938073", "name": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8938276", "species_29360" ], "products": [ "species_197277", "species_8938282" ], "modifiers": [ [ "species_10623035", "catalyst" ] ], "additional_components": [ "Q54JP6", "DDB_G0287911" ] }, "reaction_10616669": { "compartment": "compartment_5460", "id": "reaction_10616669", "reactome": "R-DDI-6806966", "name": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6807473" ], "products": [ "species_6807477" ], "modifiers": [ [ "species_10616666", "catalyst" ] ], "additional_components": [ "Q55CV0", "DDB_G0269890" ] }, "reaction_10620663": { "compartment": "compartment_70101", "id": "reaction_10620663", "reactome": "R-DDI-8869606", "name": "NMRK1 phosphorylates NAR to yield NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869365" ], "products": [ "species_70106", "species_29370", "species_197220" ], "modifiers": [ [ "species_10620660", "catalyst" ] ], "additional_components": [ "Q8T154", "DDB_G0274559", "Q55EL3", "DDB_G0269034" ] }, "reaction_10587352": { "compartment": "compartment_5460", "id": "reaction_10587352", "reactome": "R-DDI-200474", "name": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8938083", "species_113593" ], "products": [ "species_8938078", "species_8938090" ], "modifiers": [ [ "species_10587349", "catalyst" ] ], "additional_components": [ "Q54IH4", "DDB_G0288757", "species_29926" ] }, "reaction_10623128": { "compartment": "compartment_70101", "id": "reaction_10623128", "reactome": "R-DDI-8939959", "name": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8869353", "species_113592" ], "products": [ "species_1132084", "species_29360" ], "modifiers": [ [ "species_10586874", "catalyst" ] ], "additional_components": [ "species_29926", "Q54IH4", "DDB_G0288757" ] }, "reaction_10586877": { "compartment": "compartment_70101", "id": "reaction_10586877", "reactome": "R-DDI-197235", "name": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_197220" ], "products": [ "species_197256", "species_1132084" ], "modifiers": [ [ "species_10586874", "catalyst" ] ], "additional_components": [ "species_29926", "Q54IH4", "DDB_G0288757" ] }, "reaction_10586895": { "compartment": "compartment_70101", "id": "reaction_10586895", "reactome": "R-DDI-197271", "name": "NADSYN1 hexamer amidates NAAD to NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_197256", "species_113592", "species_29472" ], "products": [ "species_111294", "species_29404", "species_76577", "species_29360" ], "modifiers": [ [ "species_10586892", "catalyst" ] ], "additional_components": [ "Q54ML1", "DDB_G0285877" ] }, "reaction_10587359": { "compartment": "compartment_7660", "id": "reaction_10587359", "reactome": "R-DDI-200512", "name": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200492", "species_29358" ], "products": [ "species_8878981", "species_200499" ], "modifiers": [ [ "species_10587356", "catalyst" ] ], "additional_components": [ "Q54IH4", "DDB_G0288757", "species_29426" ] }, "reaction_10597890": { "compartment": "compartment_70101", "id": "reaction_10597890", "reactome": "R-DDI-1474184", "name": "DHNTP is dephosphorylated by PTPS to PTHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1474124" ], "products": [ "species_1475054", "species_1474179" ], "modifiers": [ [ "species_10597887", "catalyst" ] ], "additional_components": [ "species_29426", "Q1ZXI0", "DDB_G0279095" ] }, "reaction_10598274": { "compartment": "compartment_70101", "id": "reaction_10598274", "reactome": "R-DDI-1497853", "name": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10598272" ], "products": [ "species_10597898", "species_29370" ], "modifiers": [ [ "species_10597913", "catalyst" ] ], "additional_components": [ "Q54GP3", "DDB_G0290009", "Q54GP3", "DDB_G0290009", "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029" ] }, "reaction_10597879": { "compartment": "compartment_70101", "id": "reaction_10597879", "reactome": "R-DDI-1474146", "name": "GCH1 reduces GTP to dihydroneopterin triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29356" ], "products": [ "species_1474124", "species_29460" ], "modifiers": [ [ "species_10597876", "catalyst" ], [ "species_29502", "catalyst" ], [ "species_29870", "inhibitor" ] ], "additional_components": [ "Q94465", "DDB_G0288481" ] }, "reaction_10597901": { "compartment": "compartment_70101", "id": "reaction_10597901", "reactome": "R-DDI-1475414", "name": "PTHP is reduced to BH4 by sepiapterin reductase (SPR)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1474179", "species_29364" ], "products": [ "species_29870", "species_29366" ], "modifiers": [ [ "species_10597898", "catalyst" ] ], "additional_components": [ "Q54GP3", "DDB_G0290009" ] }, "reaction_10597916": { "compartment": "compartment_70101", "id": "reaction_10597916", "reactome": "R-DDI-1475422", "name": "PTPS is phosphorylated by cGMP-dependant protein kinase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10597905" ], "products": [ "species_10597887", "species_29370" ], "modifiers": [ [ "species_10597913", "catalyst" ] ], "additional_components": [ "Q1ZXI0", "DDB_G0279095", "species_29426", "Q1ZXI0", "DDB_G0279095", "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029" ] }, "reaction_10600514": { "compartment": "compartment_5460", "id": "reaction_10600514", "reactome": "R-DDI-2162186", "name": "DeMQ10H2 is methylated to Q10H2 by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162265", "species_2162212" ], "products": [ "species_2162252", "species_113529", "species_2162198" ], "modifiers": [ [ "species_10600511", "catalyst" ] ], "additional_components": [ "DDB_G0279037" ] }, "reaction_10600522": { "compartment": "compartment_70616", "id": "reaction_10600522", "reactome": "R-DDI-2162192", "name": "PHB and all-E-10PrP2 are combined into DHB by COQ2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162214", "species_2162213" ], "products": [ "species_2162207", "species_159450" ], "modifiers": [ [ "species_10600519", "catalyst" ] ], "additional_components": [ "DDB_G0281241" ] }, "reaction_10600541": { "compartment": "compartment_5460", "id": "reaction_10600541", "reactome": "R-DDI-2162253", "name": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162257", "species_2162256" ], "products": [ "species_159450", "species_2162214" ], "modifiers": [ [ "species_10600538", "catalyst" ] ], "additional_components": [ "Q54VJ9", "DDB_G0280293", "species_29926" ] }, "reaction_10600525": { "compartment": "compartment_5460", "id": "reaction_10600525", "reactome": "R-DDI-2162193", "name": "DHDB is methylated to MHDB by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162265", "species_2162209" ], "products": [ "species_2162252", "species_113529", "species_2162215" ], "modifiers": [ [ "species_10600511", "catalyst" ] ], "additional_components": [ "DDB_G0279037" ] }, "reaction_10616648": { "compartment": "compartment_17957", "id": "reaction_10616648", "reactome": "R-DDI-6806674", "name": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6806891", "species_6806657" ], "products": [ "species_6806362", "species_6806656" ], "modifiers": [ [ "species_10616645", "catalyst" ] ], "additional_components": [ "DDB_G0287509" ] }, "reaction_10600503": { "compartment": "compartment_70101", "id": "reaction_10600503", "reactome": "R-DDI-2162066", "name": "carbovir + IMP => carbovir monophosphate + inosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161514", "species_29602" ], "products": [ "species_2161176", "species_83927" ], "modifiers": [ [ "species_10581209", "catalyst" ] ], "additional_components": [ "Q54XC1", "DDB_G0279053", "species_29926" ] }, "reaction_10600506": { "compartment": "compartment_70101", "id": "reaction_10600506", "reactome": "R-DDI-2162078", "name": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161185", "species_29360" ], "products": [ "species_70106", "species_2162081", "species_73473" ], "modifiers": [ [ "species_10578698", "catalyst" ] ], "additional_components": [ "species_29426", "Q54TC2", "DDB_G0281865" ] }, "reaction_10599457": { "compartment": "compartment_70101", "id": "reaction_10599457", "reactome": "R-DDI-1855205", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994170" ], "products": [ "species_29372", "species_114520" ], "modifiers": [ [ "species_10599454", "catalyst" ] ], "additional_components": [ "species_29926", "Q8T9S7", "DDB_G0286557" ] }, "reaction_10599491": { "compartment": "compartment_876", "id": "reaction_10599491", "reactome": "R-DDI-1855213", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994170" ], "products": [ "species_29372", "species_994123" ], "modifiers": [ [ "species_10599488", "catalyst" ] ], "additional_components": [ "Q54PV1", "DDB_G0284187", "Q54W40", "DDB_G0279927", "Q8I7P3", "DDB_G0267462" ] }, "reaction_10599381": { "compartment": "compartment_70101", "id": "reaction_10599381", "reactome": "R-DDI-1855169", "name": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629741" ], "products": [ "species_994146", "species_29370" ], "modifiers": [ [ "species_10599364", "catalyst" ] ], "additional_components": [ "species_29926", "Q55D87", "DDB_G0269746" ] }, "reaction_10599367": { "compartment": "compartment_70101", "id": "reaction_10599367", "reactome": "R-DDI-1855159", "name": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994146", "species_29356" ], "products": [ "species_29372", "species_1629741" ], "modifiers": [ [ "species_10599364", "catalyst" ] ], "additional_components": [ "species_29926", "Q55D87", "DDB_G0269746" ] }, "reaction_10599417": { "compartment": "compartment_70101", "id": "reaction_10599417", "reactome": "R-DDI-1855177", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10599414", "catalyst" ] ], "additional_components": [ "Q02158", "DDB_G0292736", "species_74112" ] }, "reaction_10599449": { "compartment": "compartment_70101", "id": "reaction_10599449", "reactome": "R-DDI-1855197", "name": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994123" ], "products": [ "species_994146", "species_29370" ], "modifiers": [ [ "species_10599364", "catalyst" ] ], "additional_components": [ "species_29926", "Q55D87", "DDB_G0269746" ] }, "reaction_10599288": { "compartment": "compartment_70101", "id": "reaction_10599288", "reactome": "R-DDI-1855153", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_114520" ], "products": [ "species_29370", "species_994170" ], "modifiers": [ [ "species_10599285", "catalyst" ] ], "additional_components": [ "Q54TI0", "DDB_G0281737", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917" ] }, "reaction_10599384": { "compartment": "compartment_70101", "id": "reaction_10599384", "reactome": "R-DDI-1855171", "name": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994146", "species_29356" ], "products": [ "species_29372", "species_994123" ], "modifiers": [ [ "species_10599364", "catalyst" ] ], "additional_components": [ "species_29926", "Q55D87", "DDB_G0269746" ] }, "reaction_10599547": { "compartment": "compartment_876", "id": "reaction_10599547", "reactome": "R-DDI-1855221", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10599544", "catalyst" ] ], "additional_components": [ "Q02158", "DDB_G0292736", "species_74112" ] }, "reaction_10599387": { "compartment": "compartment_70101", "id": "reaction_10599387", "reactome": "R-DDI-1855172", "name": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994123" ], "products": [ "species_29370", "species_994170" ], "modifiers": [ [ "species_10599364", "catalyst" ] ], "additional_components": [ "species_29926", "Q55D87", "DDB_G0269746" ] }, "reaction_10599514": { "compartment": "compartment_12045", "id": "reaction_10599514", "reactome": "R-DDI-1855214", "name": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023856", "species_29356" ], "products": [ "species_114520", "species_1500596" ], "modifiers": [ [ "species_10599511", "catalyst" ] ], "additional_components": [ "Q54SA1", "DDB_G0282579", "Q54K50", "DDB_G0287649", "species_74112", "Q02158", "DDB_G0292736" ] }, "reaction_10599519": { "compartment": "compartment_70101", "id": "reaction_10599519", "reactome": "R-DDI-1855218", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994170" ], "products": [ "species_29372", "species_994123" ], "modifiers": [ [ "species_10599516", "catalyst" ] ], "additional_components": [ "species_29926", "Q55D87", "DDB_G0269746", "Q8I7P3", "DDB_G0267462", "Q54PV1", "DDB_G0284187", "Q54W40", "DDB_G0279927", "Q54D97", "DDB_G0292392" ] }, "reaction_10599345": { "compartment": "compartment_7660", "id": "reaction_10599345", "reactome": "R-DDI-1855157", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023932" ], "products": [ "species_113582", "species_2023931" ], "modifiers": [ [ "species_10599342", "catalyst" ] ], "additional_components": [ "Q54B75", "DDB_G0293860", "Q55AP4", "DDB_G0293860", "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0293860" ] }, "reaction_10599440": { "compartment": "compartment_7660", "id": "reaction_10599440", "reactome": "R-DDI-1855185", "name": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023935" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10599437", "catalyst" ] ], "additional_components": [ "DDB_G0281737" ] }, "reaction_10599568": { "compartment": "compartment_7660", "id": "reaction_10599568", "reactome": "R-DDI-1855230", "name": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023922" ], "products": [ "species_113582", "species_2023948" ], "modifiers": [ [ "species_10599342", "catalyst" ] ], "additional_components": [ "Q54B75", "DDB_G0293860", "Q55AP4", "DDB_G0293860", "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0293860" ] }, "reaction_10599460": { "compartment": "compartment_7660", "id": "reaction_10599460", "reactome": "R-DDI-1855206", "name": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023891" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10599437", "catalyst" ] ], "additional_components": [ "DDB_G0281737" ] }, "reaction_10599556": { "compartment": "compartment_7660", "id": "reaction_10599556", "reactome": "R-DDI-1855224", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023940" ], "products": [ "species_113582", "species_2023941" ], "modifiers": [ [ "species_10599342", "catalyst" ] ], "additional_components": [ "Q54B75", "DDB_G0293860", "Q55AP4", "DDB_G0293860", "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0293860" ] }, "reaction_10599463": { "compartment": "compartment_7660", "id": "reaction_10599463", "reactome": "R-DDI-1855207", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023929" ], "products": [ "species_113582", "species_2023940" ], "modifiers": [ [ "species_10599342", "catalyst" ] ], "additional_components": [ "Q54B75", "DDB_G0293860", "Q55AP4", "DDB_G0293860", "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0293860" ] }, "reaction_10599574": { "compartment": "compartment_7660", "id": "reaction_10599574", "reactome": "R-DDI-1855233", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023907" ], "products": [ "species_113582", "species_2023891" ], "modifiers": [ [ "species_10599437", "catalyst" ] ], "additional_components": [ "DDB_G0281737" ] }, "reaction_10599400": { "compartment": "compartment_7660", "id": "reaction_10599400", "reactome": "R-DDI-1855176", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023901" ], "products": [ "species_113582", "species_2023929" ], "modifiers": [ [ "species_10599397", "catalyst" ] ], "additional_components": [ "DDB_G0288351" ] }, "reaction_10599435": { "compartment": "compartment_7660", "id": "reaction_10599435", "reactome": "R-DDI-1855181", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023901" ], "products": [ "species_113582", "species_2023922" ], "modifiers": [ [ "species_10599342", "catalyst" ] ], "additional_components": [ "Q54B75", "DDB_G0293860", "Q55AP4", "DDB_G0293860", "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0293860" ] }, "reaction_10599565": { "compartment": "compartment_7660", "id": "reaction_10599565", "reactome": "R-DDI-1855228", "name": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023892" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10599437", "catalyst" ] ], "additional_components": [ "DDB_G0281737" ] }, "reaction_10599473": { "compartment": "compartment_70101", "id": "reaction_10599473", "reactome": "R-DDI-1855210", "name": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629731" ], "products": [ "species_29372", "species_426910" ], "modifiers": [ [ "species_10599305", "catalyst" ] ], "additional_components": [ "species_29926", "Q54U72", "DDB_G0281239" ] }, "reaction_10607633": { "compartment": "compartment_70101", "id": "reaction_10607633", "reactome": "R-DDI-5678327", "name": "MIOX oxidises Ins to GlcA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_426910" ], "products": [ "species_29356", "species_70106", "species_2162232" ], "modifiers": [ [ "species_10607630", "catalyst" ] ], "additional_components": [ "species_71067", "Q54GH4", "DDB_G0290161" ] }, "reaction_10599392": { "compartment": "compartment_70101", "id": "reaction_10599392", "reactome": "R-DDI-1855174", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_114520" ], "products": [ "species_29372", "species_1629739" ], "modifiers": [ [ "species_10599389", "catalyst" ] ], "additional_components": [ "Q8I7P3", "DDB_G0267462", "Q54PV1", "DDB_G0284187", "Q54W40", "DDB_G0279927", "Q54D97", "DDB_G0292392" ] }, "reaction_10599571": { "compartment": "compartment_70101", "id": "reaction_10599571", "reactome": "R-DDI-1855232", "name": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994123" ], "products": [ "species_29372", "species_1629746" ], "modifiers": [ [ "species_10599467", "catalyst" ] ], "additional_components": [ "species_29926", "Q869K3", "DDB_G0275663" ] }, "reaction_10599427": { "compartment": "compartment_70101", "id": "reaction_10599427", "reactome": "R-DDI-1855178", "name": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629756" ], "products": [ "species_1629731" ], "modifiers": [ [ "species_10599424", "catalyst" ] ], "additional_components": [ "species_29360", "Q54N49", "DDB_G0285505" ] }, "reaction_10599476": { "compartment": "compartment_70101", "id": "reaction_10599476", "reactome": "R-DDI-1855211", "name": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629753" ], "products": [ "species_29372", "species_426910" ], "modifiers": [ [ "species_10599305", "catalyst" ] ], "additional_components": [ "species_29926", "Q54U72", "DDB_G0281239" ] }, "reaction_10599308": { "compartment": "compartment_70101", "id": "reaction_10599308", "reactome": "R-DDI-1855154", "name": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_870330" ], "products": [ "species_29372", "species_426910" ], "modifiers": [ [ "species_10599305", "catalyst" ] ], "additional_components": [ "species_29926", "Q54U72", "DDB_G0281239" ] }, "reaction_10599550": { "compartment": "compartment_876", "id": "reaction_10599550", "reactome": "R-DDI-1855222", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_114520" ], "products": [ "species_29372", "species_1629739" ], "modifiers": [ [ "species_10599484", "catalyst" ] ], "additional_components": [ "Q54PV1", "DDB_G0284187", "Q54W40", "DDB_G0279927", "Q8I7P3", "DDB_G0267462" ] }, "reaction_10599470": { "compartment": "compartment_70101", "id": "reaction_10599470", "reactome": "R-DDI-1855208", "name": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629739" ], "products": [ "species_29372", "species_1629753" ], "modifiers": [ [ "species_10599467", "catalyst" ] ], "additional_components": [ "species_29926", "Q869K3", "DDB_G0275663" ] }, "reaction_10599378": { "compartment": "compartment_17957", "id": "reaction_10599378", "reactome": "R-DDI-1855163", "name": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_2024008" ], "products": [ "species_113551", "species_2024012" ], "modifiers": [ [ "species_10599375", "catalyst" ] ], "additional_components": [ "DDB_G0286993" ] }, "reaction_10599559": { "compartment": "compartment_17957", "id": "reaction_10599559", "reactome": "R-DDI-1855225", "name": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_2024018" ], "products": [ "species_113551", "species_2564836" ], "modifiers": [ [ "species_10599375", "catalyst" ] ], "additional_components": [ "DDB_G0286993" ] }, "reaction_10599452": { "compartment": "compartment_17957", "id": "reaction_10599452", "reactome": "R-DDI-1855200", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_2024002" ], "products": [ "species_113551", "species_2024016" ], "modifiers": [ [ "species_10599375", "catalyst" ] ], "additional_components": [ "DDB_G0286993" ] }, "reaction_10583665": { "compartment": "compartment_70101", "id": "reaction_10583665", "reactome": "R-DDI-156526", "name": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_5423605", "species_29364" ], "products": [ "species_29356", "species_159211", "species_29366" ], "modifiers": [ [ "species_10582258", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10605385": { "compartment": "compartment_70101", "id": "reaction_10605385", "reactome": "R-DDI-5433074", "name": "ACY1:Zn2+ dimer hydrolyses mercapturic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5490236", "species_29356" ], "products": [ "species_2022890", "species_5490231" ], "modifiers": [ [ "species_10605382", "catalyst" ] ], "additional_components": [ "CHEBI:78580", "CHEBI:78585", "CHEBI:78583", "CHEBI:78578", "species_29426", "Q55DP8", "DDB_G0270562" ] }, "reaction_10605373": { "compartment": "compartment_70101", "id": "reaction_10605373", "reactome": "R-DDI-5423647", "name": "CYP2A13 oxidises AFM1 to AFM1E", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5423629", "species_70106", "species_29368", "species_29364" ], "products": [ "species_29356", "species_5423657", "species_29366" ], "modifiers": [ [ "species_10582258", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10605375": { "compartment": "compartment_70101", "id": "reaction_10605375", "reactome": "R-DDI-5423653", "name": "MGST trimers transfer GS from GSH to AFXBO and AFNBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_5423723" ], "products": [ "species_5423730" ], "modifiers": [ [ "species_10585705", "catalyst" ] ], "additional_components": [ "species_159211", "CHEBI:78586", "CHEBI:78581", "CHEBI:78587", "Q54GA9", "DDB_G0290291" ] }, "reaction_10623024": { "compartment": "compartment_70101", "id": "reaction_10623024", "reactome": "R-DDI-8937442", "name": "CES3 hydrolyses CHEST to CHOL and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_163579" ], "products": [ "species_8876730", "species_216762" ], "modifiers": [ [ "species_10623021", "catalyst" ] ], "additional_components": [ "P21837", "DDB_G0285419", "P18142", "DDB_G0283085", "Q54N21", "DDB_G0291344", "Q54ET7", "DDB_G0291344", "Q86L18", "DDB_G0291344", "Q54WD8", "DDB_G0291344" ] }, "reaction_10583621": { "compartment": "compartment_70101", "id": "reaction_10583621", "reactome": "R-DDI-141200", "name": "MAOB:FAD oxidatively deaminates of PEA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500605", "species_29368" ], "products": [ "species_500607", "species_29382", "species_29408" ], "modifiers": [ [ "species_10583618", "catalyst" ] ], "additional_components": [ "Q54IT3", "DDB_G0288541", "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10583623": { "compartment": "compartment_70101", "id": "reaction_10583623", "reactome": "R-DDI-141202", "name": "MAOB:FAD oxidatively deaminates TYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500606", "species_29368" ], "products": [ "species_500608", "species_29382", "species_29408" ], "modifiers": [ [ "species_10583618", "catalyst" ] ], "additional_components": [ "Q54IT3", "DDB_G0288541", "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10611904": { "compartment": "compartment_5460", "id": "reaction_10611904", "reactome": "R-DDI-5696091", "name": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113532", "species_113526", "species_113521" ], "products": [ "species_113529", "species_29362", "species_113539" ], "modifiers": [ [ "species_10611901", "catalyst" ] ], "additional_components": [ "Q54FY3", "DDB_G0290479", "Q54FY1", "DDB_G0290537", "Q54FY2", "DDB_G0290537" ] }, "reaction_10578691": { "compartment": "compartment_70101", "id": "reaction_10578691", "reactome": "R-DDI-71691", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29510", "species_29360" ], "products": [ "species_70106", "species_29416", "species_73473" ], "modifiers": [ [ "species_10578688", "catalyst" ] ], "additional_components": [ "Q54IU0", "DDB_G0288521" ] }, "reaction_10578727": { "compartment": "compartment_5460", "id": "reaction_10578727", "reactome": "R-DDI-71723", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113532", "species_113526", "species_113521" ], "products": [ "species_113529", "species_29362", "species_113539" ], "modifiers": [ [ "species_10578724", "catalyst" ] ], "additional_components": [ "Q54FY3", "DDB_G0290479" ] }, "reaction_10578745": { "compartment": "compartment_70101", "id": "reaction_10578745", "reactome": "R-DDI-71735", "name": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29416", "species_76194" ], "products": [ "species_111294", "species_76183", "species_76577" ], "modifiers": [ [ "species_10578742", "catalyst" ] ], "additional_components": [ "DDB_G0277815" ] }, "reaction_10578717": { "compartment": "compartment_70101", "id": "reaction_10578717", "reactome": "R-DDI-71707", "name": "ethanol + NAD+ => acetaldehyde + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30203", "species_29360" ], "products": [ "species_70106", "species_29510", "species_73473" ], "modifiers": [ [ "species_10578714", "catalyst" ] ], "additional_components": [ "species_29426", "Q54TC2", "DDB_G0281865" ] }, "reaction_10611260": { "compartment": "compartment_70101", "id": "reaction_10611260", "reactome": "R-DDI-5692237", "name": "ADH5 oxidises S-HMGSH to S-FGSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5692221", "species_29360" ], "products": [ "species_5692249", "species_70106", "species_73473" ], "modifiers": [ [ "species_10611257", "catalyst" ] ], "additional_components": [ "species_29426", "Q54TC2", "DDB_G0281865" ] }, "reaction_10593006": { "compartment": "compartment_5460", "id": "reaction_10593006", "reactome": "R-DDI-449911", "name": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_113539" ], "products": [ "species_159448", "species_159450", "species_113559" ], "modifiers": [ [ "species_10593003", "catalyst" ] ], "additional_components": [ "DDB_G0277815" ] }, "reaction_10588946": { "compartment": "compartment_17960", "id": "reaction_10588946", "reactome": "R-DDI-217258", "name": "FMO2:FAD:Mg2+ S-oxidises MTZ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_217315" ], "products": [ "species_113519", "species_113564", "species_217320" ], "modifiers": [ [ "species_10588943", "catalyst" ] ], "additional_components": [ "species_29926", "species_113596", "Q54GT1", "DDB_G0289931", "Q54GT2", "DDB_G0289931", "Q54GT4", "DDB_G0289931", "Q54H02", "DDB_G0289931", "Q54H99", "DDB_G0289931", "Q55AS8", "DDB_G0289931", "Q54GT0", "DDB_G0289931" ] }, "reaction_10588925": { "compartment": "compartment_17960", "id": "reaction_10588925", "reactome": "R-DDI-217255", "name": "FMO1:FAD N-oxidises TAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_159154" ], "products": [ "species_113519", "species_113564", "species_217269" ], "modifiers": [ [ "species_10588922", "catalyst" ] ], "additional_components": [ "species_113596", "Q54GT4", "DDB_G0289931", "Q54H02", "DDB_G0289931", "Q54H99", "DDB_G0289931", "Q55AS8", "DDB_G0289931", "Q54GT0", "DDB_G0289931", "Q54GT1", "DDB_G0289931", "Q54GT2", "DDB_G0289931" ] }, "reaction_10583597": { "compartment": "compartment_17957", "id": "reaction_10583597", "reactome": "R-DDI-139970", "name": "FMO3:FAD N-oxidises TMA to TMAO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_30373", "species_113601" ], "products": [ "species_113519", "species_113564", "species_140963" ], "modifiers": [ [ "species_10583594", "catalyst" ] ], "additional_components": [ "species_113596", "Q54H99", "DDB_G0289931", "Q54GT2", "DDB_G0289931", "Q54GT4", "DDB_G0289931", "Q55AS8", "DDB_G0289931", "Q54GT0", "DDB_G0289931", "Q54GT1", "DDB_G0289931", "Q54H02", "DDB_G0289931" ] }, "reaction_10611272": { "compartment": "compartment_70101", "id": "reaction_10611272", "reactome": "R-DDI-5692283", "name": "ALD3A1 oxidises 4HPCP to CXPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5692409", "species_29356", "species_29366" ], "products": [ "species_70106", "species_5692433", "species_29364" ], "modifiers": [ [ "species_10611269", "catalyst" ] ], "additional_components": [ "DDB_G0292270" ] }, "reaction_10608763": { "compartment": "compartment_12045", "id": "reaction_10608763", "reactome": "R-DDI-5689000", "name": "AADAC deacetylates PHEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5689006" ], "products": [ "species_5689001", "species_5688995" ], "modifiers": [ [ "species_10608760", "catalyst" ] ], "additional_components": [ "DDB_G0283819" ] }, "reaction_10611434": { "compartment": "compartment_17957", "id": "reaction_10611434", "reactome": "R-DDI-5693691", "name": "CES1 trimer.CES2 hydrolyse COCN to BEG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_5693702" ], "products": [ "species_156540", "species_5693711", "species_5693712" ], "modifiers": [ [ "species_10611431", "catalyst" ] ], "additional_components": [ "Q54WD8", "DDB_G0291344", "Q86L18", "DDB_G0291344", "P18142", "DDB_G0283085", "P21837", "DDB_G0285419", "Q54ET7", "DDB_G0291344", "Q54N21", "DDB_G0291344" ] }, "reaction_10588801": { "compartment": "compartment_12045", "id": "reaction_10588801", "reactome": "R-DDI-211910", "name": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_211906", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211894" ], "modifiers": [ [ "species_10588798", "catalyst" ] ], "additional_components": [ "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778" ] }, "reaction_10588881": { "compartment": "compartment_12045", "id": "reaction_10588881", "reactome": "R-DDI-212005", "name": "CYP2F1 dehydrogenates 3-methylindole", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_213162", "species_113601" ], "products": [ "species_113519", "species_113564", "species_213163" ], "modifiers": [ [ "species_10588871", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10588803": { "compartment": "compartment_12045", "id": "reaction_10588803", "reactome": "R-DDI-211929", "name": "CYP2C19 5-hydroxylates omeprazole", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_211892", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211944" ], "modifiers": [ [ "species_10588798", "catalyst" ] ], "additional_components": [ "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778" ] }, "reaction_10582274": { "compartment": "compartment_12045", "id": "reaction_10582274", "reactome": "R-DDI-76453", "name": "Coumarin is 7-hydroxylated by CYP2A6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_76328", "species_113601" ], "products": [ "species_113519", "species_113564", "species_76452" ], "modifiers": [ [ "species_10582271", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10588869": { "compartment": "compartment_12045", "id": "reaction_10588869", "reactome": "R-DDI-211988", "name": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_211855", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211937" ], "modifiers": [ [ "species_10588798", "catalyst" ] ], "additional_components": [ "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778" ] }, "reaction_10582327": { "compartment": "compartment_12045", "id": "reaction_10582327", "reactome": "R-DDI-76456", "name": "O-atom dealkylation of dextromethorphan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_39703", "species_113601" ], "products": [ "species_143501", "species_113519", "species_113564", "species_76455" ], "modifiers": [ [ "species_10582324", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10588857": { "compartment": "compartment_12045", "id": "reaction_10588857", "reactome": "R-DDI-211966", "name": "CYP2D6 4-hydroxylates debrisoquine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_211993", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211952" ], "modifiers": [ [ "species_10582324", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10582263": { "compartment": "compartment_17960", "id": "reaction_10582263", "reactome": "R-DDI-76354", "name": "Vinyl chloride is oxidized to 2-Chloroethylene oxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_39417", "species_113601" ], "products": [ "species_156524", "species_113519", "species_113564" ], "modifiers": [ [ "species_10582260", "catalyst" ] ], "additional_components": [ "Q1ZXF5", "DDB_G0284535", "Q86A22", "DDB_G0272704", "Q54SK0", "DDB_G0282419", "Q54LA8", "DDB_G0286743", "Q54SV9", "DDB_G0282283", "Q1ZXG3", "DDB_G0282769", "Q54LT7", "DDB_G0286419", "Q1ZXL2", "DDB_G0275197", "Q54ZM4", "DDB_G0277545", "Q54NY3", "DDB_G0284923", "Q556M4", "DDB_G0272604", "Q1ZXL7", "DDB_G0273047", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54CS3", "DDB_G0292792", "Q1ZXA4", "DDB_G0292790", "Q556M5", "DDB_G0273045", "Q54QD0", "DDB_G0283933", "Q55AJ4", "DDB_G0271778", "Q54DT2", "DDB_G0292168", "Q54QD2", "DDB_G0283929", "Q1ZXF3", "DDB_G0284647", "Q54EM5", "DDB_G0291448" ] }, "reaction_10582265": { "compartment": "compartment_17957", "id": "reaction_10582265", "reactome": "R-DDI-76397", "name": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_113564", "species_39427", "species_113555" ], "products": [ "species_113519", "species_76396", "species_113601" ], "modifiers": [ [ "species_10582260", "catalyst" ] ], "additional_components": [ "Q1ZXF5", "DDB_G0284535", "Q86A22", "DDB_G0272704", "Q54SK0", "DDB_G0282419", "Q54LA8", "DDB_G0286743", "Q54SV9", "DDB_G0282283", "Q1ZXG3", "DDB_G0282769", "Q54LT7", "DDB_G0286419", "Q1ZXL2", "DDB_G0275197", "Q54ZM4", "DDB_G0277545", "Q54NY3", "DDB_G0284923", "Q556M4", "DDB_G0272604", "Q1ZXL7", "DDB_G0273047", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54CS3", "DDB_G0292792", "Q1ZXA4", "DDB_G0292790", "Q556M5", "DDB_G0273045", "Q54QD0", "DDB_G0283933", "Q55AJ4", "DDB_G0271778", "Q54DT2", "DDB_G0292168", "Q54QD2", "DDB_G0283929", "Q1ZXF3", "DDB_G0284647", "Q54EM5", "DDB_G0291448" ] }, "reaction_10582329": { "compartment": "compartment_17960", "id": "reaction_10582329", "reactome": "R-DDI-76475", "name": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_40795", "species_113601" ], "products": [ "species_113519", "species_113564", "species_76474", "species_76473" ], "modifiers": [ [ "species_10582260", "catalyst" ] ], "additional_components": [ "Q1ZXF5", "DDB_G0284535", "Q86A22", "DDB_G0272704", "Q54SK0", "DDB_G0282419", "Q54LA8", "DDB_G0286743", "Q54SV9", "DDB_G0282283", "Q1ZXG3", "DDB_G0282769", "Q54LT7", "DDB_G0286419", "Q1ZXL2", "DDB_G0275197", "Q54ZM4", "DDB_G0277545", "Q54NY3", "DDB_G0284923", "Q556M4", "DDB_G0272604", "Q1ZXL7", "DDB_G0273047", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54CS3", "DDB_G0292792", "Q1ZXA4", "DDB_G0292790", "Q556M5", "DDB_G0273045", "Q54QD0", "DDB_G0283933", "Q55AJ4", "DDB_G0271778", "Q54DT2", "DDB_G0292168", "Q54QD2", "DDB_G0283929", "Q1ZXF3", "DDB_G0284647", "Q54EM5", "DDB_G0291448" ] }, "reaction_10582267": { "compartment": "compartment_17960", "id": "reaction_10582267", "reactome": "R-DDI-76416", "name": "Benzene is hydroxylated to phenol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_31711", "species_156540", "species_113601" ], "products": [ "species_113519", "species_29630", "species_113564" ], "modifiers": [ [ "species_10582260", "catalyst" ] ], "additional_components": [ "Q1ZXF5", "DDB_G0284535", "Q86A22", "DDB_G0272704", "Q54SK0", "DDB_G0282419", "Q54LA8", "DDB_G0286743", "Q54SV9", "DDB_G0282283", "Q1ZXG3", "DDB_G0282769", "Q54LT7", "DDB_G0286419", "Q1ZXL2", "DDB_G0275197", "Q54ZM4", "DDB_G0277545", "Q54NY3", "DDB_G0284923", "Q556M4", "DDB_G0272604", "Q1ZXL7", "DDB_G0273047", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54CS3", "DDB_G0292792", "Q1ZXA4", "DDB_G0292790", "Q556M5", "DDB_G0273045", "Q54QD0", "DDB_G0283933", "Q55AJ4", "DDB_G0271778", "Q54DT2", "DDB_G0292168", "Q54QD2", "DDB_G0283929", "Q1ZXF3", "DDB_G0284647", "Q54EM5", "DDB_G0291448" ] }, "reaction_10582269": { "compartment": "compartment_17960", "id": "reaction_10582269", "reactome": "R-DDI-76434", "name": "Dehalogenation of carbon tetrachloride to form a free radical", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_40887" ], "products": [ "species_29572", "species_76433" ], "modifiers": [ [ "species_10582260", "catalyst" ] ], "additional_components": [ "Q1ZXF5", "DDB_G0284535", "Q86A22", "DDB_G0272704", "Q54SK0", "DDB_G0282419", "Q54LA8", "DDB_G0286743", "Q54SV9", "DDB_G0282283", "Q1ZXG3", "DDB_G0282769", "Q54LT7", "DDB_G0286419", "Q1ZXL2", "DDB_G0275197", "Q54ZM4", "DDB_G0277545", "Q54NY3", "DDB_G0284923", "Q556M4", "DDB_G0272604", "Q1ZXL7", "DDB_G0273047", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54CS3", "DDB_G0292792", "Q1ZXA4", "DDB_G0292790", "Q556M5", "DDB_G0273045", "Q54QD0", "DDB_G0283933", "Q55AJ4", "DDB_G0271778", "Q54DT2", "DDB_G0292168", "Q54QD2", "DDB_G0283929", "Q1ZXF3", "DDB_G0284647", "Q54EM5", "DDB_G0291448" ] }, "reaction_10583662": { "compartment": "compartment_17957", "id": "reaction_10583662", "reactome": "R-DDI-143468", "name": "MEOS oxidizes ethanol to acetaldehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113748", "species_113601" ], "products": [ "species_113519", "species_113564", "species_113745" ], "modifiers": [ [ "species_10582260", "catalyst" ] ], "additional_components": [ "Q1ZXF5", "DDB_G0284535", "Q86A22", "DDB_G0272704", "Q54SK0", "DDB_G0282419", "Q54LA8", "DDB_G0286743", "Q54SV9", "DDB_G0282283", "Q1ZXG3", "DDB_G0282769", "Q54LT7", "DDB_G0286419", "Q1ZXL2", "DDB_G0275197", "Q54ZM4", "DDB_G0277545", "Q54NY3", "DDB_G0284923", "Q556M4", "DDB_G0272604", "Q1ZXL7", "DDB_G0273047", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54CS3", "DDB_G0292792", "Q1ZXA4", "DDB_G0292790", "Q556M5", "DDB_G0273045", "Q54QD0", "DDB_G0283933", "Q55AJ4", "DDB_G0271778", "Q54DT2", "DDB_G0292168", "Q54QD2", "DDB_G0283929", "Q1ZXF3", "DDB_G0284647", "Q54EM5", "DDB_G0291448" ] }, "reaction_10588874": { "compartment": "compartment_12045", "id": "reaction_10588874", "reactome": "R-DDI-211991", "name": "Cyclophosphamide is 4-hydroxylated by CYP2B6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_211977", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211967" ], "modifiers": [ [ "species_10588871", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10588796": { "compartment": "compartment_12045", "id": "reaction_10588796", "reactome": "R-DDI-211881", "name": "Coumarin is 7-hydroxylated by CYP2A13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_76328", "species_113601" ], "products": [ "species_113519", "species_113564", "species_76452" ], "modifiers": [ [ "species_10588793", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10588879": { "compartment": "compartment_12045", "id": "reaction_10588879", "reactome": "R-DDI-212004", "name": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_211939" ], "products": [ "species_113519", "species_113564", "species_211927" ], "modifiers": [ [ "species_10588876", "catalyst" ] ], "additional_components": [ "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778" ] }, "reaction_10588791": { "compartment": "compartment_17960", "id": "reaction_10588791", "reactome": "R-DDI-211874", "name": "CYP2S1 4-hydroxylates atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_215573", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215584" ], "modifiers": [ [ "species_10582210", "catalyst" ] ], "additional_components": [ "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778" ] }, "reaction_10588854": { "compartment": "compartment_17960", "id": "reaction_10588854", "reactome": "R-DDI-211960", "name": "CYP2U1 19-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_216620", "species_113519", "species_113564" ], "modifiers": [ [ "species_10588851", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10588862": { "compartment": "compartment_17960", "id": "reaction_10588862", "reactome": "R-DDI-211968", "name": "CYP2W1 oxidises INDOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_216547" ], "products": [ "species_113519", "species_113564", "species_216598" ], "modifiers": [ [ "species_10588859", "catalyst" ] ], "additional_components": [ "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778" ] }, "reaction_10588867": { "compartment": "compartment_17960", "id": "reaction_10588867", "reactome": "R-DDI-211983", "name": "CYP2J2 oxidises ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215062" ], "modifiers": [ [ "species_10588864", "catalyst" ] ], "additional_components": [ "CHEBI:34130", "CHEBI:34157", "species_2142739", "CHEBI:34490", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10585571": { "compartment": "compartment_17957", "id": "reaction_10585571", "reactome": "R-DDI-174931", "name": "UGTs transfer GlcA from UDP-GlcA to O-centre substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174911", "species_174384" ], "products": [ "species_158602", "species_174914" ], "modifiers": [ [ "species_10585568", "catalyst" ] ], "additional_components": [ "species_39427", "CHEBI:16580", "species_211993", "species_29630", "CHEBI:32649", "CHEBI:65137", "CHEBI:64681", "CHEBI:32636", "Q54IL5", "DDB_G0288655", "Q55FB2", "DDB_G0268544", "Q55FX8", "DDB_G0268544", "Q55FY0", "DDB_G0268544" ] }, "reaction_10626273": { "compartment": "compartment_17957", "id": "reaction_10626273", "reactome": "R-DDI-9632039", "name": "UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159151", "species_174384" ], "products": [ "species_159160", "species_158602" ], "modifiers": [ [ "species_10585556", "catalyst" ] ], "additional_components": [ "DDB_G0288655" ] }, "reaction_10585554": { "compartment": "compartment_17957", "id": "reaction_10585554", "reactome": "R-DDI-174916", "name": "Formation of N-glucuronides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174932", "species_174384" ], "products": [ "species_158602", "species_174918" ], "modifiers": [ [ "species_10585551", "catalyst" ] ], "additional_components": [ "species_159154", "CHEBI:17688", "CHEBI:63860", "CHEBI:32663", "Q55FY0", "DDB_G0268544", "Q54IL5", "DDB_G0288655", "Q55FB2", "DDB_G0268544", "Q55FX8", "DDB_G0268544" ] }, "reaction_10623226": { "compartment": "compartment_12045", "id": "reaction_10623226", "reactome": "R-DDI-8941701", "name": "UGT1A10 transfers GlcA from UDP-GlcA to GCTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8941723", "species_174384" ], "products": [ "species_158602", "species_8941725" ], "modifiers": [ [ "species_10585549", "catalyst" ] ], "additional_components": [ "Q54IL5", "DDB_G0288655", "Q55FB2", "DDB_G0268544", "Q55FX8", "DDB_G0268544", "Q55FY0", "DDB_G0268544" ] }, "reaction_10583800": { "compartment": "compartment_17957", "id": "reaction_10583800", "reactome": "R-DDI-159179", "name": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159160", "species_174384" ], "products": [ "species_159149", "species_158602" ], "modifiers": [ [ "species_10583797", "catalyst" ] ], "additional_components": [ "Q55FY0", "DDB_G0268544", "Q54IL5", "DDB_G0288655", "Q55FB2", "DDB_G0268544", "Q55FX8", "DDB_G0268544" ] }, "reaction_10583802": { "compartment": "compartment_17957", "id": "reaction_10583802", "reactome": "R-DDI-159194", "name": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159151", "species_174384" ], "products": [ "species_159160", "species_158602" ], "modifiers": [ [ "species_10583797", "catalyst" ] ], "additional_components": [ "Q55FY0", "DDB_G0268544", "Q54IL5", "DDB_G0288655", "Q55FB2", "DDB_G0268544", "Q55FX8", "DDB_G0268544" ] }, "reaction_10626270": { "compartment": "compartment_17957", "id": "reaction_10626270", "reactome": "R-DDI-9632038", "name": "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159160", "species_174384" ], "products": [ "species_159149", "species_158602" ], "modifiers": [ [ "species_10626267", "catalyst" ] ], "additional_components": [ "Q54IL5", "DDB_G0288655" ] }, "reaction_10611928": { "compartment": "compartment_70101", "id": "reaction_10611928", "reactome": "R-DDI-5696213", "name": "AS3MT transfers CH3 from AdoMet to methylarsonite", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696224", "species_71284" ], "products": [ "species_5696211", "species_71285" ], "modifiers": [ [ "species_10611925", "catalyst" ] ], "additional_components": [ "DDB_G0285905" ] }, "reaction_10605451": { "compartment": "compartment_70101", "id": "reaction_10605451", "reactome": "R-DDI-5603114", "name": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_174390" ], "products": [ "species_111294", "species_29372", "species_71284" ], "modifiers": [ [ "species_10605448", "catalyst" ] ], "additional_components": [ "Q54F07", "DDB_G0291179", "species_29926", "species_74126", "Q54VU3", "DDB_G0280135" ] }, "reaction_10611930": { "compartment": "compartment_70101", "id": "reaction_10611930", "reactome": "R-DDI-5696220", "name": "AS3MT transfers CH3 from AdoMet to arsenite(3-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696216", "species_71284" ], "products": [ "species_71285", "species_5696214" ], "modifiers": [ [ "species_10611925", "catalyst" ] ], "additional_components": [ "DDB_G0285905" ] }, "reaction_10616063": { "compartment": "compartment_70101", "id": "reaction_10616063", "reactome": "R-DDI-6800149", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6806829", "species_71284" ], "products": [ "species_6800127", "species_71285" ], "modifiers": [ [ "species_10616057", "catalyst" ] ], "additional_components": [ "Q54DT3", "DDB_G0292048", "Q54N57", "DDB_G0285489" ] }, "reaction_10623867": { "compartment": "compartment_17963", "id": "reaction_10623867", "reactome": "R-DDI-8953499", "name": "IMPAD1 hydrolyses PAP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742343", "species_2022884" ], "products": [ "species_8851226", "species_8953493" ], "modifiers": [ [ "species_10623864", "catalyst" ], [ "species_8953505", "inhibitor" ] ], "additional_components": [ "species_29926", "Q869K3", "DDB_G0275663" ] }, "reaction_10585754": { "compartment": "compartment_70101", "id": "reaction_10585754", "reactome": "R-DDI-176606", "name": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_158466" ], "products": [ "species_29372", "species_76577" ], "modifiers": [ [ "species_10585751", "catalyst" ] ], "additional_components": [ "DDB_G0275663" ] }, "reaction_10597330": { "compartment": "compartment_70101", "id": "reaction_10597330", "reactome": "R-DDI-1247910", "name": "CNDP2:2Mn2+ dimer hydrolyses CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1247904" ], "products": [ "species_111707", "species_29424" ], "modifiers": [ [ "species_10597327", "catalyst" ] ], "additional_components": [ "species_266099", "Q54X02", "DDB_G0279291" ] }, "reaction_10585509": { "compartment": "compartment_70101", "id": "reaction_10585509", "reactome": "R-DDI-174394", "name": "GSS:Mg2+ dimer synthesizes GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174393", "species_113592", "species_29424" ], "products": [ "species_29372", "species_29370", "species_29450" ], "modifiers": [ [ "species_10585506", "catalyst" ], [ "species_29450", "inhibitor" ] ], "additional_components": [ "Q54E83", "DDB_G0291756", "species_29926" ] }, "reaction_10612601": { "compartment": "compartment_70101", "id": "reaction_10612601", "reactome": "R-DDI-6785928", "name": "CHAC1,2 cleaves GSH to OPRO and CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450" ], "products": [ "species_1247942", "species_1247904" ], "modifiers": [ [ "species_10612598", "catalyst" ] ], "additional_components": [ "Q54LB6", "DDB_G0286727" ] }, "reaction_10597340": { "compartment": "compartment_70101", "id": "reaction_10597340", "reactome": "R-DDI-1247935", "name": "OPLAH hydrolyses OPRO to L-Glu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_1247942" ], "products": [ "species_29372", "species_29404", "species_29370" ], "modifiers": [ [ "species_10597337", "catalyst" ] ], "additional_components": [ "Q54NW6", "DDB_G0284953" ] }, "reaction_10611251": { "compartment": "compartment_70101", "id": "reaction_10611251", "reactome": "R-DDI-5692232", "name": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_5692212" ], "products": [ "species_5692216", "species_29364" ], "modifiers": [ [ "species_10606592", "catalyst" ] ], "additional_components": [ "DDB_G0293850" ] }, "reaction_10585698": { "compartment": "compartment_70101", "id": "reaction_10585698", "reactome": "R-DDI-176054", "name": "GST dimers conjugate GSH with cytosolic substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_176070" ], "products": [ "species_176049" ], "modifiers": [ [ "species_10585695", "catalyst" ] ], "additional_components": [ "species_76396", "CHEBI:34718", "CHEBI:30614", "CHEBI:8927", "CHEBI:32639", "CHEBI:34479", "Q54C73", "DDB_G0293122", "Q86AU1", "DDB_G0274263", "Q556G3", "DDB_G0272632", "Q556P3", "DDB_G0273153", "Q54QV7", "DDB_G0283575", "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "Q54JU2", "DDB_G0287793", "Q54YN2", "DDB_G0278155" ] }, "reaction_10611444": { "compartment": "compartment_17957", "id": "reaction_10611444", "reactome": "R-DDI-5693724", "name": "ESD dimer hydrolyses S-FGSH to GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_5693723" ], "products": [ "species_158543", "species_194712" ], "modifiers": [ [ "species_10611441", "catalyst" ] ], "additional_components": [ "Q54RL8", "DDB_G0283037" ] }, "reaction_10585708": { "compartment": "compartment_17957", "id": "reaction_10585708", "reactome": "R-DDI-176059", "name": "GST trimers transfer GS from GSH to luminal substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158543", "species_176065" ], "products": [ "species_176048" ], "modifiers": [ [ "species_10585705", "catalyst" ] ], "additional_components": [ "species_159211", "CHEBI:27561", "species_76396", "CHEBI:32639", "CHEBI:2505", "CHEBI:35896", "Q54GA9", "DDB_G0290291" ] }, "reaction_10601760": { "compartment": "compartment_5460", "id": "reaction_10601760", "reactome": "R-DDI-2995330", "name": "COX10 transforms heme to heme O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189444", "species_2162257", "species_113521" ], "products": [ "species_2995328", "species_159450" ], "modifiers": [ [ "species_10601757", "catalyst" ] ], "additional_components": [ "DDB_G0288169" ] }, "reaction_10586066": { "compartment": "compartment_70101", "id": "reaction_10586066", "reactome": "R-DDI-189439", "name": "ALAD condenses 2 dALAs to form PBG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189489" ], "products": [ "species_29356", "species_70106", "species_189464" ], "modifiers": [ [ "species_10586063", "catalyst" ] ], "additional_components": [ "species_29426", "Q55E06", "DDB_G0269444" ] }, "reaction_10586084": { "compartment": "compartment_5460", "id": "reaction_10586084", "reactome": "R-DDI-189442", "name": "ALAS condenses SUCC-CoA and Gly to form dALA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_70958", "species_113529" ], "products": [ "species_29374", "species_189466", "species_29376" ], "modifiers": [ [ "species_10586081", "catalyst" ], [ "species_189444", "inhibitor" ] ], "additional_components": [ "Q54UX3", "DDB_G0280763" ] }, "reaction_10586036": { "compartment": "compartment_17927", "id": "reaction_10586036", "reactome": "R-DDI-189421", "name": "CPO transforms COPRO3 to PPGEN9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189461", "species_189411" ], "products": [ "species_189481", "species_189480", "species_189478" ], "modifiers": [ [ "species_10586033", "catalyst" ] ], "additional_components": [ "Q54IA7", "DDB_G0288893" ] }, "reaction_10586102": { "compartment": "compartment_70101", "id": "reaction_10586102", "reactome": "R-DDI-189488", "name": "UROS transforms HMB to URO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189449" ], "products": [ "species_189407", "species_29356" ], "modifiers": [ [ "species_10586099", "catalyst" ] ], "additional_components": [ "DDB_G0285009" ] }, "reaction_10586056": { "compartment": "compartment_70101", "id": "reaction_10586056", "reactome": "R-DDI-189425", "name": "UROD decarboxylates URO3 to COPRO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189407" ], "products": [ "species_189455", "species_113528" ], "modifiers": [ [ "species_10586053", "catalyst" ] ], "additional_components": [ "Q54DF9", "DDB_G0292294" ] }, "reaction_10601768": { "compartment": "compartment_5460", "id": "reaction_10601768", "reactome": "R-DDI-2995334", "name": "COX15 transforms heme O to heme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2995328" ], "products": [ "species_2995348" ], "modifiers": [ [ "species_10601765", "catalyst" ] ], "additional_components": [ "DDB_G0281549" ] }, "reaction_10586106": { "compartment": "compartment_70101", "id": "reaction_10586106", "reactome": "R-DDI-190141", "name": "ALAD binds to Pb2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_190173", "species_10586063" ], "products": [ "species_10586104", "species_29426" ], "modifiers": [], "additional_components": [ "species_29426", "Q55E06", "DDB_G0269444", "species_29426", "Q55E06", "DDB_G0269444", "species_391232" ] }, "reaction_10586108": { "compartment": "compartment_70101", "id": "reaction_10586108", "reactome": "R-DDI-190182", "name": "UROD decarboxylates URO1 to COPRO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_190157" ], "products": [ "species_113528", "species_190128" ], "modifiers": [ [ "species_10586053", "catalyst" ] ], "additional_components": [ "Q54DF9", "DDB_G0292294" ] }, "reaction_10594876": { "compartment": "compartment_876", "id": "reaction_10594876", "reactome": "R-DDI-917979", "name": "ABCG2 tetramer transports heme from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_71185" ], "products": [ "species_29372", "species_917877", "species_29370" ], "modifiers": [ [ "species_10594873", "catalyst" ] ], "additional_components": [ "Q54T02", "DDB_G0282103", "Q8T686", "DDB_G0289655", "Q8T689", "DDB_G0289657", "Q55DA0", "DDB_G0270826", "Q55DW4", "DDB_G0269214", "Q86HQ2", "DDB_G0274117", "Q8T685", "DDB_G0274115" ] }, "reaction_10586046": { "compartment": "compartment_17927", "id": "reaction_10586046", "reactome": "R-DDI-189423", "name": "PPO oxidises PPGEN9 to PRIN9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189461", "species_189478" ], "products": [ "species_189481", "species_189463" ], "modifiers": [ [ "species_10586043", "catalyst" ] ], "additional_components": [ "Q54DT8", "DDB_G0292040", "species_113596" ] }, "reaction_10586094": { "compartment": "compartment_5460", "id": "reaction_10586094", "reactome": "R-DDI-189465", "name": "FECH binds Fe2+ to PRIN9 to form heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189487", "species_113531" ], "products": [ "species_113529", "species_189444" ], "modifiers": [ [ "species_10586091", "catalyst" ], [ "species_391232", "inhibitor" ] ], "additional_components": [ "Q54IA8", "DDB_G0288891" ] }, "reaction_10607713": { "compartment": "compartment_70101", "id": "reaction_10607713", "reactome": "R-DDI-5679041", "name": "ABCC2 transports BMG,BDG from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5679042" ], "products": [ "species_29372", "species_5679034", "species_29370" ], "modifiers": [ [ "species_10597695", "catalyst" ] ], "additional_components": [ "species_159149", "species_159160", "species_159160", "species_159149", "Q54JR2", "DDB_G0287691", "Q54LE6", "DDB_G0286559", "Q54P13", "DDB_G0284867", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977" ] }, "reaction_10627155": { "compartment": "compartment_70101", "id": "reaction_10627155", "reactome": "R-DDI-9663492", "name": "BIL dissociates from GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627153" ], "products": [ "species_189386", "species_10585603" ], "modifiers": [], "additional_components": [ "Q86AU1", "DDB_G0274263", "Q556G3", "DDB_G0272632", "Q556P3", "DDB_G0273153", "Q54QV7", "DDB_G0283575", "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "species_159151", "Q86AU1", "DDB_G0274263", "Q556G3", "DDB_G0272632", "Q556P3", "DDB_G0273153", "Q54QV7", "DDB_G0283575", "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138" ] }, "reaction_10627157": { "compartment": "compartment_70101", "id": "reaction_10627157", "reactome": "R-DDI-9663511", "name": "BIL binds GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189386", "species_10585603" ], "products": [ "species_10627153" ], "modifiers": [], "additional_components": [ "Q86AU1", "DDB_G0274263", "Q556G3", "DDB_G0272632", "Q556P3", "DDB_G0273153", "Q54QV7", "DDB_G0283575", "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "Q86AU1", "DDB_G0274263", "Q556G3", "DDB_G0272632", "Q556P3", "DDB_G0273153", "Q54QV7", "DDB_G0283575", "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "species_159151" ] }, "reaction_10627151": { "compartment": "compartment_70101", "id": "reaction_10627151", "reactome": "R-DDI-9661417", "name": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5679042" ], "products": [ "species_29372", "species_5679034", "species_29370" ], "modifiers": [ [ "species_10594873", "catalyst" ] ], "additional_components": [ "species_159149", "species_159160", "species_159160", "species_159149", "Q54T02", "DDB_G0282103", "Q8T686", "DDB_G0289655", "Q8T689", "DDB_G0289657", "Q55DA0", "DDB_G0270826", "Q55DW4", "DDB_G0269214", "Q86HQ2", "DDB_G0274117", "Q8T685", "DDB_G0274115" ] }, "reaction_10627148": { "compartment": "compartment_70101", "id": "reaction_10627148", "reactome": "R-DDI-9661405", "name": "ABCC1 transports BIL from cytosol to extracellular region (blood)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189386" ], "products": [ "species_9661418" ], "modifiers": [ [ "species_10589142", "catalyst" ] ], "additional_components": [ "Q54JR2", "DDB_G0287691", "Q54LE6", "DDB_G0286559", "Q8ST87", "DDB_G0280977", "Q54P13", "DDB_G0284867", "Q54U44", "DDB_G0280973" ] }, "reaction_10602853": { "compartment": "compartment_7660", "id": "reaction_10602853", "reactome": "R-DDI-3371582", "name": "HSBP1 binds HSF1 trimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602818", "species_10602849" ], "products": [ "species_10602851" ], "modifiers": [], "additional_components": [ "Q54UC1", "DDB_G0281165", "Q556J3", "DDB_G0272620", "Q556J3", "DDB_G0272620", "Q54UC1", "DDB_G0281165" ] }, "reaction_10605031": { "compartment": "compartment_7660", "id": "reaction_10605031", "reactome": "R-DDI-5324617", "name": "HSP90:FKBP4:PTGES3 binds HSF1 trimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602818", "species_10605027" ], "products": [ "species_10605029" ], "modifiers": [], "additional_components": [ "Q54UC1", "DDB_G0281165", "Q54QI6", "DDB_G0283815", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "Q54QI6", "DDB_G0283815", "Q54UC1", "DDB_G0281165", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042" ] }, "reaction_10592388": { "compartment": "compartment_876", "id": "reaction_10592388", "reactome": "R-DDI-435366", "name": "ZnT1 mediates the efflux of zinc from the cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_158417" ], "modifiers": [ [ "species_10592385", "catalyst" ] ], "additional_components": [ "DDB_G0282067" ] }, "reaction_10592414": { "compartment": "compartment_70101", "id": "reaction_10592414", "reactome": "R-DDI-437162", "name": "PI3K alpha, beta, gamma convert PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10590600", "catalyst" ] ], "additional_components": [ "Q54DK0", "DDB_G0292252", "P54675", "DDB_G0275011", "P54673", "DDB_G0278727", "Q54S78", "DDB_G0282625", "Q55FX5", "DDB_G0282625", "P54674", "DDB_G0283081" ] }, "reaction_10581592": { "compartment": "compartment_13231", "id": "reaction_10581592", "reactome": "R-DDI-75823", "name": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581584" ], "products": [ "species_10581590" ], "modifiers": [], "additional_components": [ "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439" ] }, "reaction_10581596": { "compartment": "compartment_70101", "id": "reaction_10581596", "reactome": "R-DDI-75825", "name": "Proteasome mediated degradation of Cyclin D1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581594" ], "products": [ "species_10577037" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10622096": { "compartment": "compartment_171062", "id": "reaction_10622096", "reactome": "R-DDI-8875320", "name": "RAB5 GEFs exchange GTP for GDP on RAB5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10622017" ], "products": [ "species_10621999", "species_29420", "species_10622025" ], "modifiers": [ [ "species_10622093", "catalyst" ] ], "additional_components": [ "Q86JP3", "DDB_G0271984", "species_29420", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q86JP3", "DDB_G0271984", "species_29438", "Q54NU1", "DDB_G0291115", "Q54W41", "DDB_G0291115", "Q54VS5", "DDB_G0291115", "Q55AI4", "DDB_G0291115", "Q55AA6", "DDB_G0291115", "Q54F48", "DDB_G0291115", "Q54HF9", "DDB_G0291115" ] }, "reaction_10622352": { "compartment": "compartment_70101", "id": "reaction_10622352", "reactome": "R-DDI-8876616", "name": "DENND6A,B exchange GTP for GDP on RAB14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10622336" ], "products": [ "species_10621999", "species_29420", "species_10622340" ], "modifiers": [ [ "species_10622349", "catalyst" ] ], "additional_components": [ "species_29420", "P36410", "DDB_G0281337", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "P36410", "DDB_G0281337", "species_29438", "Q54VA9", "DDB_G0280481" ] }, "reaction_10622528": { "compartment": "compartment_171062", "id": "reaction_10622528", "reactome": "R-DDI-8877311", "name": "RAB31 GEFs exchange GTP for GDP on RAB31", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10622519" ], "products": [ "species_10621999", "species_29420", "species_10622523" ], "modifiers": [ [ "species_10622525", "catalyst" ] ], "additional_components": [ "species_29420", "Q8MYF2", "DDB_G0277441", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q8MYF2", "DDB_G0277441", "species_29438", "Q54W41", "DDB_G0291115", "Q54VS5", "DDB_G0291115", "Q55AI4", "DDB_G0291115", "Q55AA6", "DDB_G0291115", "Q54F48", "DDB_G0291115", "Q54NU1", "DDB_G0291115", "Q54HF9", "DDB_G0291115" ] }, "reaction_10622752": { "compartment": "compartment_12045", "id": "reaction_10622752", "reactome": "R-DDI-8877998", "name": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10622739" ], "products": [ "species_10621999", "species_29420", "species_10622743" ], "modifiers": [ [ "species_10622749", "catalyst" ] ], "additional_components": [ "Q54GY8", "DDB_G0289827", "species_29420", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54GY8", "DDB_G0289827", "species_29438", "Q54UJ4", "DDB_G0281043", "Q54DM6", "DDB_G0292124" ] }, "reaction_10622646": { "compartment": "compartment_13946", "id": "reaction_10622646", "reactome": "R-DDI-8877475", "name": "TRAPPC complexes exchange GTP for GDP on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10622591" ], "products": [ "species_10621999", "species_29420", "species_10622619" ], "modifiers": [ [ "species_10622643", "catalyst" ] ], "additional_components": [ "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "P34139", "DDB_G0283757", "species_29420", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "P34139", "DDB_G0283757", "species_29438", "Q54TK7", "DDB_G0281693", "Q54KR2", "DDB_G0287157", "Q54RV6", "DDB_G0282887", "Q54CU7", "DDB_G0292690", "Q54U24", "DDB_G0281351", "Q55EX6", "DDB_G0269062", "Q86K94", "DDB_G0277135", "Q54CV2", "DDB_G0292682", "Q54UU1", "DDB_G0280827", "Q54YG5", "DDB_G0278643", "Q557G3", "DDB_G0273467", "Q555X3", "DDB_G0274803", "Q556Z3", "DDB_G0273209" ] }, "reaction_10622583": { "compartment": "compartment_17938", "id": "reaction_10622583", "reactome": "R-DDI-8877451", "name": "MON1:CCZ1 exchanges GTP for GDP on RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10622534" ], "products": [ "species_10621999", "species_29420", "species_10622564" ], "modifiers": [ [ "species_10622580", "catalyst" ] ], "additional_components": [ "P36411", "DDB_G0269236", "species_29420", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "P36411", "DDB_G0269236", "species_29438", "Q54TG0", "DDB_G0281773", "Q54IQ5", "DDB_G0288589" ] }, "reaction_10622247": { "compartment": "compartment_263163", "id": "reaction_10622247", "reactome": "R-DDI-8876191", "name": "RAB9 GEFs exchange GTP for GDP on RAB9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10622164" ], "products": [ "species_10621999", "species_29420", "species_10622216" ], "modifiers": [ [ "species_10622244", "catalyst" ] ], "additional_components": [ "Q1ZXB9", "DDB_G0290831", "Q54FK7", "DDB_G0290779", "P36411", "DDB_G0269236", "Q54FK2", "DDB_G0290793", "Q54FK8", "DDB_G0290829", "Q1ZXB7", "DDB_G0290791", "Q54FK4", "DDB_G0290833", "Q54K69", "DDB_G0287553", "Q1ZXB8", "DDB_G0294571", "Q54FK5", "DDB_G0290789", "Q552H0", "DDB_G0294571", "species_29420", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54FK5", "DDB_G0290789", "Q54FK4", "DDB_G0290833", "P36411", "DDB_G0269236", "Q54FK8", "DDB_G0290829", "Q54FK7", "DDB_G0290779", "Q1ZXB8", "DDB_G0294571", "Q552H0", "DDB_G0294571", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "Q54FK2", "DDB_G0290793", "Q1ZXB9", "DDB_G0290831", "species_29438", "Q55DD7", "DDB_G0270918" ] }, "reaction_10622260": { "compartment": "compartment_263163", "id": "reaction_10622260", "reactome": "R-DDI-8876193", "name": "RIC1-RGP1 exchanges GTP for GDP on RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10622251" ], "products": [ "species_10621999", "species_29420", "species_10622257" ], "modifiers": [ [ "species_10618445", "catalyst" ] ], "additional_components": [ "species_29420", "Q55FK2", "DDB_G0268068", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "species_29438", "Q55FK2", "DDB_G0268068", "Q54WR7", "DDB_G0279477", "Q76NU4", "DDB_G0277397" ] }, "reaction_10622709": { "compartment": "compartment_5668575", "id": "reaction_10622709", "reactome": "R-DDI-8877760", "name": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10622680" ], "products": [ "species_10621999", "species_29420", "species_10622694" ], "modifiers": [ [ "species_10622706", "catalyst" ] ], "additional_components": [ "Q54QR3", "DDB_G0283603", "Q8MXQ2", "DDB_G0275675", "Q1ZXC0", "DDB_G0290827", "species_29420", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q8MXQ2", "DDB_G0275675", "Q54QR3", "DDB_G0283603", "Q1ZXC0", "DDB_G0290827", "species_29438", "Q55FG6", "DDB_G0268126", "Q54M79", "DDB_G0286137" ] }, "reaction_10622442": { "compartment": "compartment_171062", "id": "reaction_10622442", "reactome": "R-DDI-8876837", "name": "RAB21 GEFs exchange GTP for GDP on RAB21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10622376" ], "products": [ "species_10622380", "species_10621999", "species_29420" ], "modifiers": [ [ "species_10622439", "catalyst" ] ], "additional_components": [ "P34142", "DDB_G0286553", "species_29420", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "P34142", "DDB_G0286553", "species_29438", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54PZ6", "DDB_G0284213", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54TD5", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258" ] }, "reaction_10624461": { "compartment": "compartment_5460", "id": "reaction_10624461", "reactome": "R-DDI-8986181", "name": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624453" ], "products": [], "modifiers": [ [ "species_10624458", "catalyst" ] ], "additional_components": [ "Q54QH7", "DDB_G0283889", "DDB_G0271506" ] }, "reaction_10577280": { "compartment": "compartment_7660", "id": "reaction_10577280", "reactome": "R-DDI-69006", "name": "Phosphorylated Cdc6 is exported from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577255" ], "products": [ "species_10577278" ], "modifiers": [], "additional_components": [ "DDB_G0275983", "DDB_G0275983" ] }, "reaction_10577387": { "compartment": "compartment_70101", "id": "reaction_10577387", "reactome": "R-DDI-69015", "name": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577278", "species_10577037", "species_113592" ], "products": [ "species_10577284" ], "modifiers": [ [ "species_10577384", "catalyst" ] ], "additional_components": [ "DDB_G0275983", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q552L8", "DDB_G0275983", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54KM3", "DDB_G0287259" ] }, "reaction_10577389": { "compartment": "compartment_70101", "id": "reaction_10577389", "reactome": "R-DDI-69016", "name": "Ubiquitinated Cdc6 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577284" ], "products": [ "species_10577037" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q552L8", "DDB_G0275983", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10577276": { "compartment": "compartment_7660", "id": "reaction_10577276", "reactome": "R-DDI-69005", "name": "Cdc6 protein is phosphorylated by CDK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10576515" ], "products": [ "species_113582", "species_10577255" ], "modifiers": [ [ "species_10577273", "catalyst" ] ], "additional_components": [ "DDB_G0275983", "DDB_G0275983", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493" ] }, "reaction_10577393": { "compartment": "compartment_7660", "id": "reaction_10577393", "reactome": "R-DDI-69019", "name": "Mcm4,6,7 trimer forms and associates with the replication fork", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576576" ], "products": [ "species_10576574", "species_10577391", "species_10576559", "species_10576549" ], "modifiers": [], "additional_components": [ "Q54VI9", "DDB_G0280309", "Q86B14", "DDB_G0272760", "Q54RU0", "DDB_G0282933", "Q86IF1", "DDB_G0275623", "Q54CP4", "DDB_G0292958", "Q54LI2", "DDB_G0286623", "DDB_G0286623", "Q86B14", "DDB_G0272760", "Q54RU0", "DDB_G0282933", "Q86IF1", "DDB_G0275623", "DDB_G0292958", "DDB_G0280309" ] }, "reaction_10576897": { "compartment": "compartment_7660", "id": "reaction_10576897", "reactome": "R-DDI-68946", "name": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576678", "species_10576865" ], "products": [ "species_10576868" ], "modifiers": [ [ "species_10576894", "catalyst" ] ], "additional_components": [ "DDB_G0283073", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0283073", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54K33", "DDB_G0287629" ] }, "reaction_10576901": { "compartment": "compartment_7660", "id": "reaction_10576901", "reactome": "R-DDI-68947", "name": "Ubiquitinated Orc1 enters the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576868" ], "products": [ "species_10576899" ], "modifiers": [], "additional_components": [ "DDB_G0283073", "DDB_G0283073" ] }, "reaction_10576708": { "compartment": "compartment_7660", "id": "reaction_10576708", "reactome": "R-DDI-68944", "name": "Orc1 is phosphorylated by cyclin A/CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10576578" ], "products": [ "species_113582", "species_10576680", "species_10576678" ], "modifiers": [ [ "species_10576705", "catalyst" ] ], "additional_components": [ "Q552L8", "DDB_G0275983", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q54RN8", "DDB_G0283009", "Q86AD6", "DDB_G0271562", "Q54P62", "DDB_G0284771", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "Q54VI9", "DDB_G0280309", "Q86B14", "DDB_G0272760", "Q54RU0", "DDB_G0282933", "Q86IF1", "DDB_G0275623", "Q54CP4", "DDB_G0292958", "Q54LI2", "DDB_G0286623", "Q54VI9", "DDB_G0280309", "Q86B14", "DDB_G0272760", "Q54RU0", "DDB_G0282933", "Q86IF1", "DDB_G0275623", "Q54CP4", "DDB_G0292958", "Q54LI2", "DDB_G0286623", "Q552L8", "DDB_G0275983", "Q55CU7", "DDB_G0269894", "Q54RN8", "DDB_G0283009", "Q86AD6", "DDB_G0271562", "Q54P62", "DDB_G0284771", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "DDB_G0283073", "P34112", "DDB_G0272813" ] }, "reaction_10577243": { "compartment": "compartment_70101", "id": "reaction_10577243", "reactome": "R-DDI-68948", "name": "Ubiquitinated Orc1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576899" ], "products": [ "species_10577037" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "DDB_G0283073", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10585789": { "compartment": "compartment_7660", "id": "reaction_10585789", "reactome": "R-DDI-176956", "name": "Formation of GINS complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585775", "species_10585770", "species_10585785", "species_10585780" ], "products": [ "species_10585787" ], "modifiers": [], "additional_components": [ "DDB_G0293564", "DDB_G0289271", "DDB_G0269324", "DDB_G0291506", "Q54EH6", "DDB_G0291506", "Q55EA2", "DDB_G0269324", "Q54HR6", "DDB_G0289271", "Q54BL9", "DDB_G0293564" ] }, "reaction_10577248": { "compartment": "compartment_7660", "id": "reaction_10577248", "reactome": "R-DDI-68950", "name": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30187", "species_10576632", "species_30185", "species_29892", "species_29604" ], "products": [ "species_10577245" ], "modifiers": [ [ "species_10576604", "catalyst" ] ], "additional_components": [ "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731" ] }, "reaction_10576635": { "compartment": "compartment_7660", "id": "reaction_10576635", "reactome": "R-DDI-68913", "name": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576630", "species_30595" ], "products": [ "species_10576632", "species_10576626" ], "modifiers": [ [ "species_10576630", "catalyst" ] ], "additional_components": [ "Q54RD4", "DDB_G0283189", "Q7KWN0", "DDB_G0272740", "Q54Y85", "DDB_G0278367", "Q75JQ9", "DDB_G0272222", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "species_110614", "species_113592", "species_29494", "species_29438", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54RD4", "DDB_G0283189", "Q7KWN0", "DDB_G0272740", "Q54Y85", "DDB_G0278367", "Q75JQ9", "DDB_G0272222", "Q54RD4", "DDB_G0283189", "Q7KWN0", "DDB_G0272740", "Q54Y85", "DDB_G0278367", "Q75JQ9", "DDB_G0272222", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731" ] }, "reaction_10576580": { "compartment": "compartment_7660", "id": "reaction_10576580", "reactome": "R-DDI-68849", "name": "Mcm2-7 associates with the Cdt1:CDC6:ORC:origin complex, forming the pre-replicative complex (preRC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576576", "species_10576544" ], "products": [ "species_10576578" ], "modifiers": [], "additional_components": [ "Q54VI9", "DDB_G0280309", "Q86B14", "DDB_G0272760", "Q54RU0", "DDB_G0282933", "Q86IF1", "DDB_G0275623", "Q54CP4", "DDB_G0292958", "Q54LI2", "DDB_G0286623", "Q552L8", "DDB_G0275983", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q54RN8", "DDB_G0283009", "Q86AD6", "DDB_G0271562", "Q54P62", "DDB_G0284771", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "Q552L8", "DDB_G0275983", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q54RN8", "DDB_G0283009", "Q86AD6", "DDB_G0271562", "Q54P62", "DDB_G0284771", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "Q54VI9", "DDB_G0280309", "Q86B14", "DDB_G0272760", "Q54RU0", "DDB_G0282933", "Q86IF1", "DDB_G0275623", "Q54CP4", "DDB_G0292958", "Q54LI2", "DDB_G0286623" ] }, "reaction_10585791": { "compartment": "compartment_7660", "id": "reaction_10585791", "reactome": "R-DDI-176973", "name": "Association of MCM8 with ORC:origin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576508", "species_10576532" ], "products": [ "species_10576536" ], "modifiers": [], "additional_components": [ "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q86AD6", "DDB_G0271562", "Q54P62", "DDB_G0284771", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "DDB_G0283009", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q54RN8", "DDB_G0283009", "Q86AD6", "DDB_G0271562", "Q54P62", "DDB_G0284771", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214" ] }, "reaction_10576540": { "compartment": "compartment_7660", "id": "reaction_10576540", "reactome": "R-DDI-68688", "name": "CDC6 association with ORC:origin complexes mediated by MCM8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576536", "species_10576515" ], "products": [ "species_10576538" ], "modifiers": [], "additional_components": [ "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q54RN8", "DDB_G0283009", "Q86AD6", "DDB_G0271562", "Q54P62", "DDB_G0284771", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "DDB_G0275983", "Q552L8", "DDB_G0275983", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q54RN8", "DDB_G0283009", "Q86AD6", "DDB_G0271562", "Q54P62", "DDB_G0284771", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214" ] }, "reaction_10576526": { "compartment": "compartment_7660", "id": "reaction_10576526", "reactome": "R-DDI-68637", "name": "CDC6 protein is synthesized under the control of E2F transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10576515" ], "modifiers": [ [ "species_10576524", "catalyst" ] ], "additional_components": [ "DDB_G0275983", "Q54Q23", "DDB_G0284129" ] }, "reaction_10576672": { "compartment": "compartment_7660", "id": "reaction_10576672", "reactome": "R-DDI-68917", "name": "Cdc45 associates with the pre-replicative complex at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576668", "species_10576642" ], "products": [ "species_10576670" ], "modifiers": [], "additional_components": [ "Q54DK3", "DDB_G0292152", "P34112", "DDB_G0272813", "Q54VI9", "DDB_G0280309", "Q86B14", "DDB_G0272760", "Q54RU0", "DDB_G0282933", "Q86IF1", "DDB_G0275623", "Q54CP4", "DDB_G0292958", "Q54LI2", "DDB_G0286623", "Q552L8", "DDB_G0275983", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q54RN8", "DDB_G0283009", "Q86AD6", "DDB_G0271562", "Q54P62", "DDB_G0284771", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "DDB_G0267748", "Q55GA4", "DDB_G0267748", "Q54DK3", "DDB_G0292152", "P34112", "DDB_G0272813", "Q54VI9", "DDB_G0280309", "Q86B14", "DDB_G0272760", "Q54RU0", "DDB_G0282933", "Q86IF1", "DDB_G0275623", "Q54CP4", "DDB_G0292958", "Q54LI2", "DDB_G0286623", "Q552L8", "DDB_G0275983", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q54RN8", "DDB_G0283009", "Q86AD6", "DDB_G0271562", "Q54P62", "DDB_G0284771", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214" ] }, "reaction_10577252": { "compartment": "compartment_7660", "id": "reaction_10577252", "reactome": "R-DDI-68960", "name": "DNA polymerase epsilon binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576626", "species_68419" ], "products": [ "species_10576628" ], "modifiers": [], "additional_components": [ "Q54RD4", "DDB_G0283189", "Q7KWN0", "DDB_G0272740", "Q54Y85", "DDB_G0278367", "Q75JQ9", "DDB_G0272222", "Q54RD4", "DDB_G0283189", "Q7KWN0", "DDB_G0272740", "Q54Y85", "DDB_G0278367", "Q75JQ9", "DDB_G0272222" ] }, "reaction_10576637": { "compartment": "compartment_7660", "id": "reaction_10576637", "reactome": "R-DDI-68914", "name": "DNA polymerase alpha:primase binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576604", "species_10576628" ], "products": [ "species_10576630" ], "modifiers": [], "additional_components": [ "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54RD4", "DDB_G0283189", "Q7KWN0", "DDB_G0272740", "Q54Y85", "DDB_G0278367", "Q75JQ9", "DDB_G0272222", "Q54RD4", "DDB_G0283189", "Q7KWN0", "DDB_G0272740", "Q54Y85", "DDB_G0278367", "Q75JQ9", "DDB_G0272222", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731" ] }, "reaction_10589187": { "compartment": "compartment_7660", "id": "reaction_10589187", "reactome": "R-DDI-266204", "name": "Association of HMGB1/HMGB2 with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589181", "species_29428" ], "products": [ "species_10589185" ], "modifiers": [], "additional_components": [ "DDB_G0270260", "Q55C24", "DDB_G0270260" ] }, "reaction_10589444": { "compartment": "compartment_70101", "id": "reaction_10589444", "reactome": "R-DDI-351948", "name": "Mitochondrial recruitment of Drp1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589436" ], "products": [ "species_10589442" ], "modifiers": [ [ "species_10589400", "catalyst" ] ], "additional_components": [ "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "DDB_G0287543" ] }, "reaction_10589430": { "compartment": "compartment_13231", "id": "reaction_10589430", "reactome": "R-DDI-351947", "name": "Nuclear translocation of catalytic domain of Mst3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589416" ], "products": [ "species_10589428" ], "modifiers": [], "additional_components": [ "O61122", "DDB_G0286359", "Q54DC8", "DDB_G0292350", "O61122", "DDB_G0286359", "Q54DC8", "DDB_G0292350" ] }, "reaction_10601347": { "compartment": "compartment_70101", "id": "reaction_10601347", "reactome": "R-DDI-2529020", "name": "CK2 phosphorylates condensin I subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10601313" ], "products": [ "species_29370", "species_10601303" ], "modifiers": [ [ "species_10601344", "catalyst" ] ], "additional_components": [ "Q54PK4", "DDB_G0284499", "Q54B17", "DDB_G0293984", "Q54DR4", "DDB_G0292066", "Q54WY1", "DDB_G0279329", "Q54LV0", "DDB_G0286403", "Q54DR4", "DDB_G0292066", "Q54LV0", "DDB_G0286403", "Q54PK4", "DDB_G0284499", "Q54B17", "DDB_G0293984", "Q54WY1", "DDB_G0279329", "Q54PF1", "DDB_G0284601", "Q02720", "DDB_G0276885", "Q54LR6", "DDB_G0286481" ] }, "reaction_10601315": { "compartment": "compartment_70101", "id": "reaction_10601315", "reactome": "R-DDI-2529015", "name": "Dephosphorylation of CK2-modified condensin I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10601303" ], "products": [ "species_29372", "species_10601313" ], "modifiers": [ [ "species_2529006", "catalyst" ] ], "additional_components": [ "Q54DR4", "DDB_G0292066", "Q54LV0", "DDB_G0286403", "Q54PK4", "DDB_G0284499", "Q54B17", "DDB_G0293984", "Q54WY1", "DDB_G0279329", "Q54PK4", "DDB_G0284499", "Q54B17", "DDB_G0293984", "Q54DR4", "DDB_G0292066", "Q54WY1", "DDB_G0279329", "Q54LV0", "DDB_G0286403" ] }, "reaction_10605458": { "compartment": "compartment_876", "id": "reaction_10605458", "reactome": "R-DDI-5610727", "name": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_111294", "species_30389" ], "modifiers": [ [ "species_10605455", "catalyst" ] ], "additional_components": [ "species_29926" ] }, "reaction_10605510": { "compartment": "compartment_5263228", "id": "reaction_10605510", "reactome": "R-DDI-5610733", "name": "KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605506", "species_10605504" ], "products": [ "species_10605508" ], "modifiers": [], "additional_components": [ "DDB_G0284471", "species_29420", "species_29438", "species_29420", "species_29438", "Q6S003", "DDB_G0284471" ] }, "reaction_10605534": { "compartment": "compartment_5263232", "id": "reaction_10605534", "reactome": "R-DDI-5610749", "name": "cAMP dissociates PKA, promoting GLI processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605530", "species_30389" ], "products": [ "species_10605518", "species_10605532" ], "modifiers": [], "additional_components": [ "P05987", "DDB_G0279413", "Q8MM62", "DDB_G0276027", "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029", "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029", "species_30389", "P05987", "DDB_G0279413", "Q8MM62", "DDB_G0276027" ] }, "reaction_10580620": { "compartment": "compartment_7660", "id": "reaction_10580620", "reactome": "R-DDI-73757", "name": "Binding of RRN3 to RNA Polymerase I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580616", "species_10580611" ], "products": [ "species_10580618" ], "modifiers": [], "additional_components": [ "DDB_G0289587", "Q54YF5", "DDB_G0278263", "Q54R66", "DDB_G0283365", "Q54EH2", "DDB_G0291636", "Q54BM1", "DDB_G0293560", "Q54SN4", "DDB_G0282339", "Q54FA8", "DDB_G0291037", "Q55AB6", "DDB_G0272036", "Q86H36", "DDB_G0275759", "Q54FE8", "DDB_G0290909", "Q54YW8", "DDB_G0278039", "Q55FA4", "DDB_G0268198", "Q54YF5", "DDB_G0278263", "Q54R66", "DDB_G0283365", "Q54EH2", "DDB_G0291636", "Q54BM1", "DDB_G0293560", "Q54SN4", "DDB_G0282339", "Q54FA8", "DDB_G0291037", "Q55AB6", "DDB_G0272036", "Q86H36", "DDB_G0275759", "Q54FE8", "DDB_G0290909", "Q54YW8", "DDB_G0278039", "Q55FA4", "DDB_G0268198", "Q54HB0", "DDB_G0289587" ] }, "reaction_10581489": { "compartment": "compartment_350", "id": "reaction_10581489", "reactome": "R-DDI-74986", "name": "Elongation of pre-rRNA transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74985", "species_30595" ], "products": [ "species_74985" ], "modifiers": [ [ "species_10580705", "catalyst" ], [ "species_10581487", "catalyst" ] ], "additional_components": [ "species_110614", "species_113592", "species_29494", "species_29438", "Q54YF5", "DDB_G0278263", "Q54R66", "DDB_G0283365", "Q54EH2", "DDB_G0291636", "Q54BM1", "DDB_G0293560", "Q54SN4", "DDB_G0282339", "Q54FA8", "DDB_G0291037", "Q55AB6", "DDB_G0272036", "Q86H36", "DDB_G0275759", "Q54FE8", "DDB_G0290909", "Q54YW8", "DDB_G0278039", "Q55FA4", "DDB_G0268198", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q554V6", "DDB_G0274953", "P26355", "DDB_G0275617", "Q55C69", "DDB_G0270198", "Q54RN0", "DDB_G0283023", "Q54RQ4", "DDB_G0283023", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863" ] }, "reaction_10580707": { "compartment": "compartment_7660", "id": "reaction_10580707", "reactome": "R-DDI-73769", "name": "Loss of Rrn3 from RNA Polymerase I promoter escape complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580701" ], "products": [ "species_10580616", "species_10580705" ], "modifiers": [], "additional_components": [ "Q554V6", "DDB_G0274953", "P26355", "DDB_G0275617", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54YF5", "DDB_G0278263", "Q54R66", "DDB_G0283365", "Q54EH2", "DDB_G0291636", "Q54BM1", "DDB_G0293560", "Q54SN4", "DDB_G0282339", "Q54FA8", "DDB_G0291037", "Q55AB6", "DDB_G0272036", "Q86H36", "DDB_G0275759", "Q54FE8", "DDB_G0290909", "Q54YW8", "DDB_G0278039", "Q55FA4", "DDB_G0268198", "Q54HB0", "DDB_G0289587", "DDB_G0289587", "Q54YF5", "DDB_G0278263", "Q54R66", "DDB_G0283365", "Q54EH2", "DDB_G0291636", "Q54BM1", "DDB_G0293560", "Q54SN4", "DDB_G0282339", "Q54FA8", "DDB_G0291037", "Q55AB6", "DDB_G0272036", "Q86H36", "DDB_G0275759", "Q54FE8", "DDB_G0290909", "Q54YW8", "DDB_G0278039", "Q55FA4", "DDB_G0268198", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q554V6", "DDB_G0274953", "P26355", "DDB_G0275617" ] }, "reaction_10590390": { "compartment": "compartment_70101", "id": "reaction_10590390", "reactome": "R-DDI-389788", "name": "Activation of PAKs by RAC1 and CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583374", "species_10590384" ], "products": [ "species_10590388", "species_10590386" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459", "P34144", "DDB_G0277869", "species_29438", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459" ] }, "reaction_10592081": { "compartment": "compartment_70101", "id": "reaction_10592081", "reactome": "R-DDI-432232", "name": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10592069" ], "products": [ "species_10592079", "species_29370" ], "modifiers": [ [ "species_10582991", "catalyst" ] ], "additional_components": [ "Q9U8P7", "DDB_G0267378", "Q54FQ9", "DDB_G0290691", "Q54V53", "DDB_G0280537", "Q54FQ9", "DDB_G0290691", "Q54V53", "DDB_G0280537", "Q9U8P7", "DDB_G0267378", "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029" ] }, "reaction_10592022": { "compartment": "compartment_876", "id": "reaction_10592022", "reactome": "R-DDI-432010", "name": "Aquaporin-1 passively transports water into cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10592019", "catalyst" ] ], "additional_components": [ "Q9U8P7", "DDB_G0267378" ] }, "reaction_10592024": { "compartment": "compartment_876", "id": "reaction_10592024", "reactome": "R-DDI-432054", "name": "Aquaporin-1 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10592019", "catalyst" ] ], "additional_components": [ "Q9U8P7", "DDB_G0267378" ] }, "reaction_10592059": { "compartment": "compartment_876", "id": "reaction_10592059", "reactome": "R-DDI-432067", "name": "Aquaporin-4 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10592056", "catalyst" ] ], "additional_components": [ "Q54FQ9", "DDB_G0290691", "Q54V53", "DDB_G0280537", "Q9U8P7", "DDB_G0267378" ] }, "reaction_10592046": { "compartment": "compartment_876", "id": "reaction_10592046", "reactome": "R-DDI-432065", "name": "p-S256-Aquaporin-2 passively transports water into cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10592043", "catalyst" ] ], "additional_components": [ "Q54V53", "DDB_G0280537", "Q9U8P7", "DDB_G0267378", "Q54FQ9", "DDB_G0290691" ] }, "reaction_10625623": { "compartment": "compartment_70101", "id": "reaction_10625623", "reactome": "R-DDI-9029987", "name": "p-S216-CDC25C translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581495" ], "products": [ "species_10581499" ], "modifiers": [], "additional_components": [ "DDB_G0283617", "DDB_G0283617" ] }, "reaction_10581576": { "compartment": "compartment_7660", "id": "reaction_10581576", "reactome": "R-DDI-75809", "name": "Phosphorylation of Cdc25C at Ser216 by CHEK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10581492" ], "products": [ "species_113582", "species_10581495" ], "modifiers": [ [ "species_10577617", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "DDB_G0280321" ] }, "reaction_10608080": { "compartment": "compartment_7660", "id": "reaction_10608080", "reactome": "R-DDI-5683774", "name": "p-T68-CHEK2 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608076" ], "products": [ "species_10608078" ], "modifiers": [], "additional_components": [ "DDB_G0280321", "Q54VI1", "DDB_G0280321" ] }, "reaction_10608083": { "compartment": "compartment_7660", "id": "reaction_10608083", "reactome": "R-DDI-5683792", "name": "p-T68-CHEK2 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608078", "species_29358" ], "products": [ "species_113582", "species_10577617" ], "modifiers": [ [ "species_10608078", "catalyst" ] ], "additional_components": [ "Q54VI1", "DDB_G0280321", "DDB_G0280321", "Q54VI1", "DDB_G0280321" ] }, "reaction_10581497": { "compartment": "compartment_7660", "id": "reaction_10581497", "reactome": "R-DDI-75010", "name": "Phosphorylation of Cdc25C at Ser 216 by Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10581492" ], "products": [ "species_113582", "species_10581495" ], "modifiers": [ [ "species_10577605", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "DDB_G0279719" ] }, "reaction_10601585": { "compartment": "compartment_70101", "id": "reaction_10601585", "reactome": "R-DDI-2730872", "name": "Activation of Calcineurin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599837", "species_10583042", "species_74016" ], "products": [ "species_10601542" ], "modifiers": [], "additional_components": [ "Q55G87", "DDB_G0267446", "species_29426", "Q7YSW8", "DDB_G0276883", "CHEBI:29034", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "species_74112", "Q55G87", "DDB_G0267446", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "species_29426", "Q7YSW8", "DDB_G0276883", "CHEBI:29034" ] }, "reaction_10601566": { "compartment": "compartment_70101", "id": "reaction_10601566", "reactome": "R-DDI-2730867", "name": "Translocation of CaN:CaM:NFAT to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601546" ], "products": [ "species_10601564" ], "modifiers": [], "additional_components": [ "species_74112", "Q55G87", "DDB_G0267446", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "species_29426", "Q7YSW8", "DDB_G0276883", "CHEBI:29034", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "species_74112", "Q7YSW8", "DDB_G0276883", "CHEBI:29034", "species_29426", "Q55G87", "DDB_G0267446" ] }, "reaction_10605809": { "compartment": "compartment_876", "id": "reaction_10605809", "reactome": "R-DDI-5624494", "name": "RAF1 binds p21 RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590651", "species_10585144" ], "products": [ "species_10605804" ], "modifiers": [], "additional_components": [ "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54TM7", "DDB_G0281557" ] }, "reaction_10605807": { "compartment": "compartment_876", "id": "reaction_10605807", "reactome": "R-DDI-5624492", "name": "PAK phosphorylates p21 RAF1 on S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605804", "species_113592" ], "products": [ "species_29370", "species_10605796" ], "modifiers": [ [ "species_10590386", "catalyst" ] ], "additional_components": [ "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54TM7", "DDB_G0281557", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459" ] }, "reaction_10605769": { "compartment": "compartment_70101", "id": "reaction_10605769", "reactome": "R-DDI-5618331", "name": "HDAC6 deacetylates microtubules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605766", "species_76194" ], "products": [ "species_10589898", "species_76183" ], "modifiers": [ [ "species_10605033", "catalyst" ] ], "additional_components": [ "species_29438", "species_29420", "species_29438", "species_29420", "DDB_G0279267" ] }, "reaction_10608705": { "compartment": "compartment_5460", "id": "reaction_10608705", "reactome": "R-DDI-5688289", "name": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_10608691" ], "products": [ "species_5688337", "species_10608695", "species_5688274" ], "modifiers": [ [ "species_10608702", "catalyst" ] ], "additional_components": [ "Q55BJ9", "DDB_G0271106", "Q54Z60", "DDB_G0277815", "Q54KB7", "DDB_G0287469", "Q54KB7", "DDB_G0287469", "Q54Z60", "DDB_G0277815", "Q55BJ9", "DDB_G0271106", "Q54LF0", "DDB_G0286671", "species_29426" ] }, "reaction_10608718": { "compartment": "compartment_17927", "id": "reaction_10608718", "reactome": "R-DDI-5688294", "name": "SIRT5 deacetylates Cytochrome C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5688282", "species_10608708" ], "products": [ "species_5688281", "species_10583365", "species_5688340" ], "modifiers": [ [ "species_10608715", "catalyst" ] ], "additional_components": [ "DDB_G0275537", "DDB_G0275537", "species_29426", "Q55DB0", "DDB_G0270928" ] }, "reaction_10624307": { "compartment": "compartment_876", "id": "reaction_10624307", "reactome": "R-DDI-8982019", "name": "Active G alpha (i)i1/i2/i3 binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584927", "species_10624289" ], "products": [ "species_10624305" ], "modifiers": [], "additional_components": [ "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438" ] }, "reaction_10585810": { "compartment": "compartment_70101", "id": "reaction_10585810", "reactome": "R-DDI-177284", "name": "PKA phosphorylates PDE4B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10585799" ], "products": [ "species_10585807", "species_29370" ], "modifiers": [ [ "species_10582991", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121", "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121", "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029" ] }, "reaction_10626513": { "compartment": "compartment_70101", "id": "reaction_10626513", "reactome": "R-DDI-9644869", "name": "p-S54-PDE4B hydrolyses cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10585807", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121" ] }, "reaction_10583101": { "compartment": "compartment_70101", "id": "reaction_10583101", "reactome": "R-DDI-111962", "name": "PDE4A,C,D hydrolyse cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10583098", "catalyst" ] ], "additional_components": [ "Q86H13", "DDB_G0289121", "Q23917", "DDB_G0284331" ] }, "reaction_10584502": { "compartment": "compartment_947587", "id": "reaction_10584502", "reactome": "R-DDI-167415", "name": "G-protein alpha subunit is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29420", "species_10582953" ], "products": [ "species_29438", "species_10583103" ], "modifiers": [ [ "species_10582951", "catalyst" ] ], "additional_components": [ "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29420", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351" ] }, "reaction_10584945": { "compartment": "compartment_876", "id": "reaction_10584945", "reactome": "R-DDI-170672", "name": "Galpha-olf:GTP binds to adenylate cyclase and activates it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583022", "species_10584867" ], "products": [ "species_10584942" ], "modifiers": [ [ "species_10583022", "catalyst" ] ], "additional_components": [ "species_29926", "Q03100", "DDB_G0281545", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545", "species_29926", "Q03100", "DDB_G0281545" ] }, "reaction_10584961": { "compartment": "compartment_876", "id": "reaction_10584961", "reactome": "R-DDI-170685", "name": "Adenylaye cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584942" ], "products": [ "species_10584956", "species_29372" ], "modifiers": [ [ "species_10584942", "catalyst" ] ], "additional_components": [ "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29420", "species_29926", "Q03100", "DDB_G0281545", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545" ] }, "reaction_10584954": { "compartment": "compartment_876", "id": "reaction_10584954", "reactome": "R-DDI-170676", "name": "Adenylate cyclase converts ATP into cyclic AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_111294", "species_30389" ], "modifiers": [ [ "species_10584942", "catalyst" ] ], "additional_components": [ "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545" ] }, "reaction_10584958": { "compartment": "compartment_876", "id": "reaction_10584958", "reactome": "R-DDI-170677", "name": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584956" ], "products": [ "species_10583022", "species_10584933" ], "modifiers": [], "additional_components": [ "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29420", "species_29926", "Q03100", "DDB_G0281545", "species_29926", "Q03100", "DDB_G0281545", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29420" ] }, "reaction_10589829": { "compartment": "compartment_947587", "id": "reaction_10589829", "reactome": "R-DDI-380073", "name": "Liganded Gi-activating GPCR acts as a GEF for Gi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589822", "species_29438" ], "products": [ "species_29420", "species_10589826" ], "modifiers": [ [ "species_10589822", "catalyst" ] ], "additional_components": [ "species_916850", "Q54F54", "DDB_G0291095", "Q54K09", "DDB_G0287905", "Q54ET0", "DDB_G0291356", "species_29420", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P36408", "DDB_G0277143", "P36408", "DDB_G0277143", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_916850", "Q54F54", "DDB_G0291095", "Q54K09", "DDB_G0287905", "Q54ET0", "DDB_G0291356", "species_916850", "Q54F54", "DDB_G0291095", "Q54K09", "DDB_G0287905", "Q54ET0", "DDB_G0291356", "species_29420", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P36408", "DDB_G0277143" ] }, "reaction_10624310": { "compartment": "compartment_876", "id": "reaction_10624310", "reactome": "R-DDI-8982020", "name": "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624305" ], "products": [ "species_29372", "species_10624291" ], "modifiers": [ [ "species_10624305", "catalyst" ] ], "additional_components": [ "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29420", "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438" ] }, "reaction_10624293": { "compartment": "compartment_876", "id": "reaction_10624293", "reactome": "R-DDI-8982012", "name": "G alpha (i):RGS dissociates to inactive G alpha (i)i1/i2/i3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624291" ], "products": [ "species_10624289", "species_10584947" ], "modifiers": [], "additional_components": [ "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29420", "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "species_29420", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343" ] }, "reaction_10601449": { "compartment": "compartment_876", "id": "reaction_10601449", "reactome": "R-DDI-2534365", "name": "Slo3 Potassium Transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10601446", "catalyst" ] ], "additional_components": [ "Q55CU6", "DDB_G0269896", "Q54SN1", "DDB_G0282291" ] }, "reaction_10583314": { "compartment": "compartment_7660", "id": "reaction_10583314", "reactome": "R-DDI-113407", "name": "DSIF complex binds to RNA Pol II (hypophosphorylated)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583215", "species_10583165" ], "products": [ "species_10583217" ], "modifiers": [], "additional_components": [ "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q75JA4", "DDB_G0271690", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q75JA4", "DDB_G0271690", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10583222": { "compartment": "compartment_7660", "id": "reaction_10583222", "reactome": "R-DDI-112383", "name": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580699", "species_10583170", "species_10578883" ], "products": [ "species_10583215", "species_10580699" ], "modifiers": [ [ "species_10583170", "catalyst" ] ], "additional_components": [ "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "DDB_G0271690", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q75JA4", "DDB_G0271690", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "DDB_G0271690" ] }, "reaction_10583320": { "compartment": "compartment_7660", "id": "reaction_10583320", "reactome": "R-DDI-113412", "name": "Pol II elongation complex moves on the template as transcript elongates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583290", "species_30595" ], "products": [ "species_10583302", "species_30595" ], "modifiers": [], "additional_components": [ "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "species_110614", "species_113592", "species_29494", "species_29438", "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "species_110614", "species_113592", "species_29494", "species_29438" ] }, "reaction_10583306": { "compartment": "compartment_7660", "id": "reaction_10583306", "reactome": "R-DDI-112396", "name": "Separation of elongating transcript from template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583302" ], "products": [ "species_10583304" ], "modifiers": [], "additional_components": [ "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10583292": { "compartment": "compartment_7660", "id": "reaction_10583292", "reactome": "R-DDI-112385", "name": "Addition of nucleotides leads to transcript elongation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583288", "species_30595" ], "products": [ "species_10583290", "species_10580699" ], "modifiers": [], "additional_components": [ "Q86A81", "DDB_G0274327", "Q55F33", "DDB_G0268922", "Q75JA4", "DDB_G0271690", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q55A48", "DDB_G0272354", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "species_110614", "species_113592", "species_29494", "species_29438", "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729" ] }, "reaction_10583692": { "compartment": "compartment_7660", "id": "reaction_10583692", "reactome": "R-DDI-156682", "name": "PLK1 phosphorylates NUDC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10583686" ], "products": [ "species_10583690", "species_29370" ], "modifiers": [ [ "species_10583678", "catalyst" ] ], "additional_components": [ "DDB_G0286159", "DDB_G0286159", "DDB_G0274503" ] }, "reaction_10601043": { "compartment": "compartment_1598585", "id": "reaction_10601043", "reactome": "R-DDI-2466068", "name": "Phosphorylation of cohesin by PLK1 at chromosomal arms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10601028" ], "products": [ "species_29370", "species_10601040" ], "modifiers": [ [ "species_10585345", "catalyst" ] ], "additional_components": [ "Q550H7", "DDB_G0276977", "Q552D9", "DDB_G0276101", "Q54QR0", "DDB_G0283681", "Q54E85", "DDB_G0291752", "Q552Q7", "DDB_G0275929", "Q552Q7", "DDB_G0275929", "Q552D9", "DDB_G0276101", "Q54QR0", "DDB_G0283681", "Q550H7", "DDB_G0276977", "Q54E85", "DDB_G0291752", "DDB_G0274503" ] }, "reaction_10589619": { "compartment": "compartment_876", "id": "reaction_10589619", "reactome": "R-DDI-375405", "name": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_375409" ], "products": [ "species_70106", "species_375414" ], "modifiers": [ [ "species_10589616", "catalyst" ] ], "additional_components": [ "species_379717", "species_159549", "species_159549", "species_379717", "DDB_G0293074" ] }, "reaction_10589624": { "compartment": "compartment_876", "id": "reaction_10589624", "reactome": "R-DDI-375417", "name": "SLC36A1-mediated uptake of glycine, proline, and alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_375400" ], "products": [ "species_70106", "species_375411" ], "modifiers": [ [ "species_10589621", "catalyst" ] ], "additional_components": [ "species_389664", "species_379717", "species_159549", "species_159549", "species_379717", "species_389664", "DDB_G0293074" ] }, "reaction_10581901": { "compartment": "compartment_7660", "id": "reaction_10581901", "reactome": "R-DDI-76056", "name": "Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581835", "species_10581897" ], "products": [ "species_10581899" ], "modifiers": [], "additional_components": [ "Q8T1F9", "DDB_G0275127", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54YB5", "DDB_G0278321", "Q54FU1", "DDB_G0290591", "Q54U85", "DDB_G0281215", "Q54R53", "DDB_G0283405", "P26355", "DDB_G0275617", "Q557J3", "DDB_G0273425", "Q54LP2", "DDB_G0286521", "Q54R66", "DDB_G0283365", "Q54IM0", "DDB_G0288665", "Q55FJ5", "DDB_G0268080", "Q86JM3", "DDB_G0272022", "Q54EH2", "DDB_G0291636", "Q54K02", "DDB_G0287707", "Q54SN4", "DDB_G0282339", "Q54FA8", "DDB_G0291037", "Q8T1V7", "DDB_G0277671", "Q86JI9", "DDB_G0271514", "Q55AB6", "DDB_G0272036", "Q86AQ5", "DDB_G0277199", "Q54IZ9", "DDB_G0288449", "Q54YW8", "DDB_G0278039", "Q557J3", "DDB_G0273425", "Q54LP2", "DDB_G0286521", "Q54R66", "DDB_G0283365", "Q54IM0", "DDB_G0288665", "Q55FJ5", "DDB_G0268080", "Q86JM3", "DDB_G0272022", "Q54EH2", "DDB_G0291636", "Q54K02", "DDB_G0287707", "Q54SN4", "DDB_G0282339", "Q54FA8", "DDB_G0291037", "Q8T1V7", "DDB_G0277671", "Q86JI9", "DDB_G0271514", "Q55AB6", "DDB_G0272036", "Q86AQ5", "DDB_G0277199", "Q54IZ9", "DDB_G0288449", "Q54YW8", "DDB_G0278039", "Q8T1F9", "DDB_G0275127", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54YB5", "DDB_G0278321", "Q54FU1", "DDB_G0290591", "Q54U85", "DDB_G0281215", "Q54R53", "DDB_G0283405", "P26355", "DDB_G0275617" ] }, "reaction_10627075": { "compartment": "compartment_876", "id": "reaction_10627075", "reactome": "R-DDI-9657599", "name": "Dual mechanism MAP2K inhibitors bind MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657567", "species_10607239" ], "products": [ "species_10607241" ], "modifiers": [], "additional_components": [ "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54HS0", "DDB_G0289277", "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54HS0", "DDB_G0289277" ] }, "reaction_10607298": { "compartment": "compartment_74700", "id": "reaction_10607298", "reactome": "R-DDI-5674130", "name": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607294", "species_113592" ], "products": [ "species_29370", "species_10607296" ], "modifiers": [], "additional_components": [ "Q54H44", "DDB_G0289711", "Q54F59", "DDB_G0291091", "Q86J23", "DDB_G0274833", "Q54TM7", "DDB_G0281557", "Q54HS0", "DDB_G0289277", "Q54H44", "DDB_G0289711", "Q54F59", "DDB_G0291091", "Q86J23", "DDB_G0274833", "Q54TM7", "DDB_G0281557", "Q54HS0", "DDB_G0289277" ] }, "reaction_10607253": { "compartment": "compartment_876", "id": "reaction_10607253", "reactome": "R-DDI-5672978", "name": "RAF phosphorylates MAP2K dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607239" ], "products": [ "species_10607230", "species_29370" ], "modifiers": [ [ "species_10607239", "catalyst" ], [ "species_10607241", "inhibitor" ], [ "species_10607251", "inhibitor" ] ], "additional_components": [ "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54HS0", "DDB_G0289277", "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54HS0", "DDB_G0289277", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54HS0", "DDB_G0289277", "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54HS0", "DDB_G0289277", "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438" ] }, "reaction_10627079": { "compartment": "compartment_876", "id": "reaction_10627079", "reactome": "R-DDI-9657606", "name": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607230", "species_9657574" ], "products": [ "species_10607237" ], "modifiers": [], "additional_components": [ "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54HS0", "DDB_G0289277", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54HS0", "DDB_G0289277", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438" ] }, "reaction_10627077": { "compartment": "compartment_876", "id": "reaction_10627077", "reactome": "R-DDI-9657603", "name": "Dual mechanism MAPK inhibitors bind MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607230", "species_9657570" ], "products": [ "species_10607243" ], "modifiers": [], "additional_components": [ "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54HS0", "DDB_G0289277", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54HS0", "DDB_G0289277", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438" ] }, "reaction_10627083": { "compartment": "compartment_876", "id": "reaction_10627083", "reactome": "R-DDI-9657608", "name": "Single mechanism MAPK inhibitors bind phosphorylated MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657577", "species_10607234" ], "products": [ "species_10627081" ], "modifiers": [], "additional_components": [ "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54HS0", "DDB_G0289277", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54HS0", "DDB_G0289277", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438" ] }, "reaction_10607245": { "compartment": "compartment_876", "id": "reaction_10607245", "reactome": "R-DDI-5672973", "name": "MAP2Ks phosphorylate MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607230", "species_113592" ], "products": [ "species_29370", "species_10607234" ], "modifiers": [ [ "species_10607230", "catalyst" ], [ "species_10607237", "inhibitor" ], [ "species_10607241", "inhibitor" ], [ "species_10607243", "inhibitor" ] ], "additional_components": [ "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54HS0", "DDB_G0289277", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602093", "species_113560" ], "products": [ "species_2485002", "species_10602506" ], "modifiers": [ [ "species_10602530", "catalyst" ] ], "additional_components": [ "Q54QM3", "DDB_G0283859", "Q54NG3", "DDB_G0285275", "B0G130", "DDB_G0279699", "Q869X5", "DDB_G0279699", "Q54PN9", "DDB_G0284411" ] }, "reaction_10602468": { "compartment": "compartment_7660", "id": "reaction_10602468", "reactome": "R-DDI-3318413", "name": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600607", "species_113560" ], "products": [ "species_2485002", "species_10602427" ], "modifiers": [ [ "species_10602465", "catalyst" ] ], "additional_components": [ "DDB_G0291185", "DDB_G0291185", "B0G130", "DDB_G0279699", "Q869X5", "DDB_G0279699", "Q54NG3", "DDB_G0285275", "Q54PN9", "DDB_G0284411" ] }, "reaction_10602922": { "compartment": "compartment_7660", "id": "reaction_10602922", "reactome": "R-DDI-3662318", "name": "Type B histone acetlytransferase complex acetylates histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581418", "species_113560" ], "products": [ "species_2485002", "species_10602900" ], "modifiers": [ [ "species_10602919", "catalyst" ] ], "additional_components": [ "DDB_G0276863", "DDB_G0276863", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q86J12", "DDB_G0274269" ] }, "reaction_10606579": { "compartment": "compartment_7660", "id": "reaction_10606579", "reactome": "R-DDI-5661121", "name": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606223", "species_113671", "species_113685" ], "products": [ "species_10604220", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10604227", "catalyst" ] ], "additional_components": [ "DDB_G0269194" ] }, "reaction_10604197": { "compartment": "compartment_7660", "id": "reaction_10604197", "reactome": "R-DDI-4754176", "name": "JMJD6 demethylates MeR3-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602206", "species_113671", "species_113685" ], "products": [ "species_10602093", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10604194", "catalyst" ] ], "additional_components": [ "DDB_G0279409" ] }, "reaction_10606581": { "compartment": "compartment_7660", "id": "reaction_10606581", "reactome": "R-DDI-5661122", "name": "JMJD6 demethylates Me2R3-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604669", "species_113671", "species_113685" ], "products": [ "species_10602206", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10604194", "catalyst" ] ], "additional_components": [ "DDB_G0279409" ] }, "reaction_10604215": { "compartment": "compartment_7660", "id": "reaction_10604215", "reactome": "R-DDI-4754181", "name": "KDM5A-D demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10604199", "species_113685" ], "products": [ "species_10602091", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10604212", "catalyst" ] ], "additional_components": [ "Q55ER4", "DDB_G0268778" ] }, "reaction_10606583": { "compartment": "compartment_7660", "id": "reaction_10606583", "reactome": "R-DDI-5661124", "name": "JMJD6 demethylates MeR4-HIST1H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604614", "species_113671", "species_113685" ], "products": [ "species_10581418", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10604194", "catalyst" ] ], "additional_components": [ "DDB_G0276863", "DDB_G0276863", "DDB_G0279409" ] }, "reaction_10606585": { "compartment": "compartment_7660", "id": "reaction_10606585", "reactome": "R-DDI-5661125", "name": "JMJD6 demethylates Me2sR4-HIST1H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604678", "species_113671", "species_113685" ], "products": [ "species_10604614", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10604194", "catalyst" ] ], "additional_components": [ "DDB_G0276863", "DDB_G0276863", "DDB_G0279409" ] }, "reaction_10604232": { "compartment": "compartment_7660", "id": "reaction_10604232", "reactome": "R-DDI-4754187", "name": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604220", "species_113671", "species_113685" ], "products": [ "species_29478", "species_159942", "species_159939", "species_10604225" ], "modifiers": [ [ "species_10604227", "catalyst" ] ], "additional_components": [ "DDB_G0269194" ] }, "reaction_10606572": { "compartment": "compartment_7660", "id": "reaction_10606572", "reactome": "R-DDI-5661116", "name": "KDM5A-D demethylate Me3K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604902", "species_113671", "species_113685" ], "products": [ "species_29478", "species_10604199", "species_159942", "species_159939" ], "modifiers": [ [ "species_10604212", "catalyst" ] ], "additional_components": [ "Q55ER4", "DDB_G0268778" ] }, "reaction_10627346": { "compartment": "compartment_7660", "id": "reaction_10627346", "reactome": "R-DDI-9679787", "name": "HDAC1:2-containing complex binds HDAC2 Inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603176", "species_9679795" ], "products": [ "species_10603179" ], "modifiers": [], "additional_components": [ "Q54PU3", "DDB_G0284289", "Q54LI3", "DDB_G0286805", "Q54QG3", "DDB_G0283845", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q55FN5", "DDB_G0268024", "Q54NX4", "DDB_G0285057", "Q54PU3", "DDB_G0284289", "Q54LI3", "DDB_G0286805", "Q54QG3", "DDB_G0283845", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q55FN5", "DDB_G0268024", "Q54NX4", "DDB_G0285057" ] }, "reaction_10603206": { "compartment": "compartment_7660", "id": "reaction_10603206", "reactome": "R-DDI-3782655", "name": "HDAC10 deacetylates histone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10603132" ], "products": [ "species_10603138", "species_5566518" ], "modifiers": [ [ "species_10603203", "catalyst" ] ], "additional_components": [ "Q76NW2", "DDB_G0276863", "Q54X15", "DDB_G0279267", "Q54VQ7", "DDB_G0280195" ] }, "reaction_10603181": { "compartment": "compartment_7660", "id": "reaction_10603181", "reactome": "R-DDI-3769447", "name": "HDAC1:2-containing complex deacetylate histones", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10603132" ], "products": [ "species_10603138", "species_5566518" ], "modifiers": [ [ "species_10603176", "catalyst" ], [ "species_10603179", "inhibitor" ] ], "additional_components": [ "Q76NW2", "DDB_G0276863", "Q54PU3", "DDB_G0284289", "Q54LI3", "DDB_G0286805", "Q54QG3", "DDB_G0283845", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q55FN5", "DDB_G0268024", "Q54NX4", "DDB_G0285057", "Q54PU3", "DDB_G0284289", "Q54LI3", "DDB_G0286805", "Q54QG3", "DDB_G0283845", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q55FN5", "DDB_G0268024", "Q54NX4", "DDB_G0285057" ] }, "reaction_10604673": { "compartment": "compartment_7660", "id": "reaction_10604673", "reactome": "R-DDI-5205824", "name": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10604664" ], "products": [ "species_77502", "species_10604671" ], "modifiers": [ [ "species_10604619", "catalyst" ] ], "additional_components": [ "DDB_G0289445" ] }, "reaction_10604624": { "compartment": "compartment_7660", "id": "reaction_10604624", "reactome": "R-DDI-5205798", "name": "PRMT1,PRMT6 methylate arginine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10581418" ], "products": [ "species_77502", "species_10604614" ], "modifiers": [ [ "species_10604621", "catalyst" ] ], "additional_components": [ "DDB_G0276863", "DDB_G0276863", "Q54EF2", "DDB_G0291556", "Q54HI0", "DDB_G0289445" ] }, "reaction_10604709": { "compartment": "compartment_7660", "id": "reaction_10604709", "reactome": "R-DDI-5205867", "name": "PRMT1 methylates arginine-12 of histone H2A (H2AR11)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10604693" ], "products": [ "species_77502", "species_10604706" ], "modifiers": [ [ "species_10602098", "catalyst" ] ], "additional_components": [ "DDB_G0291556" ] }, "reaction_10604900": { "compartment": "compartment_7660", "id": "reaction_10604900", "reactome": "R-DDI-5229203", "name": "PRMT6 methylates histone H2A arginine-30 (H2AR29)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10604885" ], "products": [ "species_77502", "species_10604898" ], "modifiers": [ [ "species_10604619", "catalyst" ] ], "additional_components": [ "DDB_G0289445" ] }, "reaction_10604791": { "compartment": "compartment_7660", "id": "reaction_10604791", "reactome": "R-DDI-5225602", "name": "WDR5 binds Me2sR3-replicative histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604420", "species_10604769" ], "products": [ "species_10604789" ], "modifiers": [], "additional_components": [ "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127" ] }, "reaction_10604795": { "compartment": "compartment_7660", "id": "reaction_10604795", "reactome": "R-DDI-5225649", "name": "RBBP7 binds histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602093", "species_10602917" ], "products": [ "species_10604793" ], "modifiers": [ [ "species_10604769", "inhibitor" ] ], "additional_components": [ "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565" ] }, "reaction_10604653": { "compartment": "compartment_7660", "id": "reaction_10604653", "reactome": "R-DDI-5205820", "name": "PRMT6 methylates arginine-4 of histone H2A (H2AR3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10604637" ], "products": [ "species_77502", "species_10604650" ], "modifiers": [ [ "species_10604619", "catalyst" ] ], "additional_components": [ "DDB_G0289445" ] }, "reaction_10606590": { "compartment": "compartment_7660", "id": "reaction_10606590", "reactome": "R-DDI-5661126", "name": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10604614" ], "products": [ "species_77502", "species_10606588" ], "modifiers": [ [ "species_10604621", "catalyst" ] ], "additional_components": [ "DDB_G0276863", "DDB_G0276863", "Q54EF2", "DDB_G0291556", "Q54HI0", "DDB_G0289445" ] }, "reaction_10606145": { "compartment": "compartment_7660", "id": "reaction_10606145", "reactome": "R-DDI-5637686", "name": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10602091" ], "products": [ "species_77502", "species_10604199" ], "modifiers": [ [ "species_10606142", "catalyst" ] ], "additional_components": [ "Q54HS3", "DDB_G0289257", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q54MH6", "DDB_G0285847", "Q55AQ4", "DDB_G0271754", "Q54IV4", "DDB_G0288495", "Q55D68", "DDB_G0269768" ] }, "reaction_10604245": { "compartment": "compartment_7660", "id": "reaction_10604245", "reactome": "R-DDI-4827382", "name": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10604187" ], "products": [ "species_77502", "species_10604237" ], "modifiers": [ [ "species_10604242", "catalyst" ] ], "additional_components": [ "DDB_G0289257" ] }, "reaction_10606212": { "compartment": "compartment_7660", "id": "reaction_10606212", "reactome": "R-DDI-5649764", "name": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10606199" ], "products": [ "species_77502", "species_10606204" ], "modifiers": [ [ "species_10606209", "catalyst" ] ], "additional_components": [ "DDB_G0271626" ] }, "reaction_10604439": { "compartment": "compartment_7660", "id": "reaction_10604439", "reactome": "R-DDI-5159245", "name": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10602093" ], "products": [ "species_77502", "species_10602091" ], "modifiers": [ [ "species_10604436", "catalyst" ] ], "additional_components": [ "Q54J80", "DDB_G0288227", "Q54HS3", "DDB_G0289257", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q54MH6", "DDB_G0285847", "Q55AQ4", "DDB_G0271754", "Q55D68", "DDB_G0269768" ] }, "reaction_10606166": { "compartment": "compartment_7660", "id": "reaction_10606166", "reactome": "R-DDI-5638157", "name": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10604185" ], "products": [ "species_77502", "species_10606159" ], "modifiers": [ [ "species_10604312", "catalyst" ] ], "additional_components": [ "Q54ZX8", "DDB_G0294629", "Q54D67", "DDB_G0294629", "Q557F6", "DDB_G0294629", "Q54DL6", "DDB_G0294629", "Q557F7", "DDB_G0294629", "Q54GG3", "DDB_G0294629", "Q55DC8", "DDB_G0270830", "Q54IV4", "DDB_G0288495", "Q55FX4", "DDB_G0294629", "Q54R14", "DDB_G0294629", "B0G196", "DDB_G0294629", "Q54XN6", "DDB_G0294629", "C7G064", "DDB_G0294629" ] }, "reaction_10604315": { "compartment": "compartment_7660", "id": "reaction_10604315", "reactome": "R-DDI-4827383", "name": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10602093" ], "products": [ "species_77502", "species_10604185" ], "modifiers": [ [ "species_10604312", "catalyst" ] ], "additional_components": [ "Q54ZX8", "DDB_G0294629", "Q54D67", "DDB_G0294629", "Q557F6", "DDB_G0294629", "Q54DL6", "DDB_G0294629", "Q557F7", "DDB_G0294629", "Q54GG3", "DDB_G0294629", "Q55DC8", "DDB_G0270830", "Q54IV4", "DDB_G0288495", "Q55FX4", "DDB_G0294629", "Q54R14", "DDB_G0294629", "B0G196", "DDB_G0294629", "Q54XN6", "DDB_G0294629", "C7G064", "DDB_G0294629" ] }, "reaction_10606219": { "compartment": "compartment_7660", "id": "reaction_10606219", "reactome": "R-DDI-5649799", "name": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10606204" ], "products": [ "species_77502", "species_10606217" ], "modifiers": [ [ "species_10606209", "catalyst" ] ], "additional_components": [ "DDB_G0271626" ] }, "reaction_10604909": { "compartment": "compartment_7660", "id": "reaction_10604909", "reactome": "R-DDI-5244692", "name": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10604199" ], "products": [ "species_77502", "species_10604902" ], "modifiers": [ [ "species_10604906", "catalyst" ], [ "species_10604671", "inhibitor" ] ], "additional_components": [ "Q54HS3", "DDB_G0289257", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q54MH6", "DDB_G0285847", "Q55AQ4", "DDB_G0271754", "Q54IV4", "DDB_G0288495" ] }, "reaction_10606221": { "compartment": "compartment_7660", "id": "reaction_10606221", "reactome": "R-DDI-5649801", "name": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10602093" ], "products": [ "species_77502", "species_10606199" ], "modifiers": [ [ "species_10606209", "catalyst" ] ], "additional_components": [ "DDB_G0271626" ] }, "reaction_10589176": { "compartment": "compartment_876", "id": "reaction_10589176", "reactome": "R-DDI-266082", "name": "ABCG1-mediated transport of intracellular cholesterol to the cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_216762", "species_113592" ], "products": [ "species_29372", "species_29370", "species_171095" ], "modifiers": [ [ "species_10589173", "catalyst" ] ], "additional_components": [ "Q8T689", "DDB_G0289657", "Q54T02", "DDB_G0282103", "Q55DA0", "DDB_G0270826", "Q55DW4", "DDB_G0269214", "Q86HQ2", "DDB_G0274117", "Q8T685", "DDB_G0274115", "Q8T686", "DDB_G0289655" ] }, "reaction_10604343": { "compartment": "compartment_7660", "id": "reaction_10604343", "reactome": "R-DDI-5082356", "name": "HSF1-mediated gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604325" ], "products": [ "species_10604331" ], "modifiers": [ [ "species_10604336", "catalyst" ], [ "species_10604341", "catalyst" ] ], "additional_components": [ "Q54UC1", "DDB_G0281165", "P54651", "DDB_G0267400", "P36415", "DDB_G0269144", "Q556J3", "DDB_G0272620", "Q54UC1", "DDB_G0281165", "Q54UC1", "DDB_G0281165" ] }, "reaction_10604364": { "compartment": "compartment_7660", "id": "reaction_10604364", "reactome": "R-DDI-5082405", "name": "Phosphorylation of HSF1 at Ser326 induces transactivation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10602818" ], "products": [ "species_113582", "species_10604341" ], "modifiers": [ [ "species_10604361", "catalyst" ] ], "additional_components": [ "Q54UC1", "DDB_G0281165", "Q54UC1", "DDB_G0281165", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54D08", "DDB_G0292592" ] }, "reaction_10590646": { "compartment": "compartment_70101", "id": "reaction_10590646", "reactome": "R-DDI-392834", "name": "Activation of EPACs by cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10590642" ], "products": [ "species_10590644" ], "modifiers": [], "additional_components": [ "Q54TK8", "DDB_G0281573", "Q8IS12", "DDB_G0275703", "Q54TK8", "DDB_G0281573", "Q8IS12", "DDB_G0275703", "species_30389" ] }, "reaction_10594377": { "compartment": "compartment_70101", "id": "reaction_10594377", "reactome": "R-DDI-913996", "name": "PKA/PKG phosphorylate Rap1GAP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10590629" ], "products": [ "species_10594364", "species_29370" ], "modifiers": [ [ "species_10594374", "catalyst" ] ], "additional_components": [ "Q54Q75", "DDB_G0284065", "Q54SS8", "DDB_G0282247", "Q54Q75", "DDB_G0284065", "Q54SS8", "DDB_G0282247", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029", "P34099", "DDB_G0283907" ] }, "reaction_10590634": { "compartment": "compartment_70101", "id": "reaction_10590634", "reactome": "R-DDI-392513", "name": "Rap1 signal termination by Rap1GAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589457" ], "products": [ "species_111294", "species_10589459" ], "modifiers": [ [ "species_10590631", "catalyst" ] ], "additional_components": [ "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "species_29438", "species_29420", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "Q54Q75", "DDB_G0284065", "Q54SS8", "DDB_G0282247" ] }, "reaction_10590655": { "compartment": "compartment_70101", "id": "reaction_10590655", "reactome": "R-DDI-392835", "name": "Rap1 sequesters Raf1 to inhibit ERK cascade", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590651", "species_10589457" ], "products": [ "species_10590653" ], "modifiers": [], "additional_components": [ "DDB_G0281557", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "species_29438", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "species_29438", "Q54TM7", "DDB_G0281557" ] }, "reaction_10582742": { "compartment": "compartment_7660", "id": "reaction_10582742", "reactome": "R-DDI-110243", "name": "Excision of 8-oxoguanine by OGG1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582737" ], "products": [ "species_110242", "species_10582739" ], "modifiers": [ [ "species_10582737", "catalyst" ] ], "additional_components": [ "Q54CZ3", "DDB_G0292618", "Q54CZ3", "DDB_G0292618", "Q54CZ3", "DDB_G0292618" ] }, "reaction_10582763": { "compartment": "compartment_7660", "id": "reaction_10582763", "reactome": "R-DDI-110246", "name": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582758" ], "products": [ "species_5635947", "species_10582760" ], "modifiers": [ [ "species_10582758", "catalyst" ] ], "additional_components": [ "Q1ZXP7", "DDB_G0270764", "Q1ZXP7", "DDB_G0270764", "Q1ZXP7", "DDB_G0270764" ] }, "reaction_10592618": { "compartment": "compartment_70101", "id": "reaction_10592618", "reactome": "R-DDI-445072", "name": "Interaction of PAK1 with Rac1-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590366", "species_10583374", "species_113592" ], "products": [ "species_10590364", "species_29370", "species_10592615" ], "modifiers": [ [ "species_10590364", "catalyst" ] ], "additional_components": [ "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "P34144", "DDB_G0277869", "species_29438", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "Q869N2", "DDB_G0276459", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "P34144", "DDB_G0277869", "species_29438", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459" ] }, "reaction_10612893": { "compartment": "compartment_984", "id": "reaction_10612893", "reactome": "R-DDI-6789310", "name": "LIPs hydrolyse TG to DAG and RCOOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174675", "species_6789319" ], "modifiers": [ [ "species_10612890", "catalyst" ] ], "additional_components": [ "Q55EU1", "DDB_G0268966", "Q55EU8", "DDB_G0268966", "Q55EU9", "DDB_G0268966" ] }, "reaction_10594235": { "compartment": "compartment_876", "id": "reaction_10594235", "reactome": "R-DDI-879411", "name": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594231", "species_10594227" ], "products": [ "species_10594233" ], "modifiers": [], "additional_components": [ "Q55C24", "DDB_G0270260", "species_1236719", "CHEBI:60125", "CHEBI:53014", "DDB_G0287833", "Q54JR7", "DDB_G0287833", "Q55C24", "DDB_G0270260", "species_1236719", "CHEBI:60125", "CHEBI:53014" ] }, "reaction_10617470": { "compartment": "compartment_7660", "id": "reaction_10617470", "reactome": "R-DDI-6810233", "name": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10617458" ], "products": [ "species_113582", "species_10617467" ], "modifiers": [ [ "species_10617458", "catalyst" ] ], "additional_components": [ "Q54B89", "DDB_G0293830", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54XM9", "DDB_G0278843", "Q54CN8", "DDB_G0292838", "Q54IW7", "DDB_G0288471", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "P54685", "DDB_G0285417", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "P26355", "DDB_G0275617", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54FD6", "DDB_G0290929", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54XM9", "DDB_G0278843", "Q54CN8", "DDB_G0292838", "Q54IW7", "DDB_G0288471", "Q54B89", "DDB_G0293830", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "P54685", "DDB_G0285417", "P26355", "DDB_G0275617", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54FD6", "DDB_G0290929", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54B89", "DDB_G0293830", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54XM9", "DDB_G0278843", "Q54CN8", "DDB_G0292838", "Q54IW7", "DDB_G0288471", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "P54685", "DDB_G0285417", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "P26355", "DDB_G0275617", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54FD6", "DDB_G0290929" ] }, "reaction_10627486": { "compartment": "compartment_70101", "id": "reaction_10627486", "reactome": "R-DDI-9712274", "name": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622861", "species_9714134" ], "products": [ "species_10627484" ], "modifiers": [], "additional_components": [ "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903", "Q55BF8", "DDB_G0271372", "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903", "Q55BF8", "DDB_G0271372" ] }, "reaction_10591159": { "compartment": "compartment_20699", "id": "reaction_10591159", "reactome": "R-DDI-421831", "name": "trans-Golgi Network Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10591135", "species_10591129", "species_10591141", "species_10591123" ], "products": [ "species_10589294", "species_29372", "species_10591157" ], "modifiers": [], "additional_components": [ "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "O00909", "DDB_G0289173", "Q54Y34", "DDB_G0292332", "Q1ZXA5", "DDB_G0292332", "Q54YV7", "DDB_G0278057", "Q54HK2", "DDB_G0289435", "Q55AR1", "DDB_G0271792", "Q54JJ3", "DDB_G0288015", "Q54SH9", "DDB_G0282457", "Q54V41", "DDB_G0280633", "Q54V47", "DDB_G0280621", "Q54VB0", "DDB_G0280479", "species_29438", "Q54HS9", "DDB_G0289247", "Q54WW3", "DDB_G0279359", "B0G185", "DDB_G0295711", "Q8I8U2", "DDB_G0281957", "Q54X82", "DDB_G0279141", "species_29420", "Q54V41", "DDB_G0280633", "Q54Y34", "DDB_G0292332", "Q54HK2", "DDB_G0289435", "Q54YV7", "DDB_G0278057", "Q54JJ3", "DDB_G0288015", "Q54V47", "DDB_G0280621", "O00909", "DDB_G0289173", "Q54VB0", "DDB_G0280479", "Q55AR1", "DDB_G0271792", "Q1ZXA5", "DDB_G0292332", "Q54SH9", "DDB_G0282457", "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q54HS9", "DDB_G0289247", "Q54WW3", "DDB_G0279359", "B0G185", "DDB_G0295711", "Q8I8U2", "DDB_G0281957", "Q54X82", "DDB_G0279141" ] }, "reaction_10591320": { "compartment": "compartment_70101", "id": "reaction_10591320", "reactome": "R-DDI-421835", "name": "trans-Golgi Network Vesicle Scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10591157" ], "products": [ "species_10591135", "species_29372", "species_29420", "species_10591141", "species_10591317" ], "modifiers": [ [ "species_10591157", "catalyst" ] ], "additional_components": [ "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q54HS9", "DDB_G0289247", "Q54WW3", "DDB_G0279359", "B0G185", "DDB_G0295711", "Q8I8U2", "DDB_G0281957", "Q54X82", "DDB_G0279141", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q8I8U2", "DDB_G0281957", "Q54HS9", "DDB_G0289247", "B0G185", "DDB_G0295711", "Q54WW3", "DDB_G0279359", "Q54X82", "DDB_G0279141", "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q54HS9", "DDB_G0289247", "Q54WW3", "DDB_G0279359", "B0G185", "DDB_G0295711", "Q8I8U2", "DDB_G0281957", "Q54X82", "DDB_G0279141" ] }, "reaction_10589780": { "compartment": "compartment_70101", "id": "reaction_10589780", "reactome": "R-DDI-379382", "name": "MAOA:FAD deaminates DA to DOPAC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29368", "species_159362" ], "products": [ "species_9677997", "species_29382", "species_29408" ], "modifiers": [ [ "species_10583604", "catalyst" ] ], "additional_components": [ "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10589782": { "compartment": "compartment_70101", "id": "reaction_10589782", "reactome": "R-DDI-379395", "name": "MAOA:FAD deaminates 3MT to HVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8954997", "species_29356", "species_29368" ], "products": [ "species_9677992", "species_29382", "species_29408" ], "modifiers": [ [ "species_10583604", "catalyst" ] ], "additional_components": [ "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10604787": { "compartment": "compartment_70101", "id": "reaction_10604787", "reactome": "R-DDI-5223317", "name": "ABCB9 transports peptides from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5223341" ], "products": [ "species_5223344", "species_29372", "species_29370" ], "modifiers": [ [ "species_10604784", "catalyst" ] ], "additional_components": [ "Q54BU4", "DDB_G0293416" ] }, "reaction_10597683": { "compartment": "compartment_17906", "id": "reaction_10597683", "reactome": "R-DDI-1369065", "name": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1369066", "species_29356", "species_113592" ], "products": [ "species_29372", "species_29370", "species_1369027" ], "modifiers": [ [ "species_10597680", "catalyst" ] ], "additional_components": [ "Q8T9W2", "DDB_G0292554" ] }, "reaction_10590190": { "compartment": "compartment_70616", "id": "reaction_10590190", "reactome": "R-DDI-382560", "name": "ABC7, mABC1 and mABC2 mediate heme transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_189444", "species_113521" ], "products": [ "species_113548", "species_113581", "species_71185" ], "modifiers": [ [ "species_10590187", "catalyst" ] ], "additional_components": [ "Q8T9W2", "DDB_G0292554" ] }, "reaction_10619974": { "compartment": "compartment_876", "id": "reaction_10619974", "reactome": "R-DDI-8866851", "name": "CFTR transits to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619958" ], "products": [ "species_10590243" ], "modifiers": [], "additional_components": [ "Q54U44", "DDB_G0280973", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q54LE6", "DDB_G0286559", "Q54P13", "DDB_G0284867", "Q54U44", "DDB_G0280973" ] }, "reaction_10618468": { "compartment": "compartment_70101", "id": "reaction_10618468", "reactome": "R-DDI-8848053", "name": "ABCA5 transports CHOL from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_8848047" ], "products": [ "species_29372", "species_176478", "species_29370" ], "modifiers": [ [ "species_10618465", "catalyst" ] ], "additional_components": [ "Q54BT5", "DDB_G0293436", "Q55BC0", "DDB_G0271138", "Q555Z5", "DDB_G0274121", "Q8T6J1", "DDB_G0291245", "Q8T5Z7", "DDB_G0291994", "Q8T6J5", "DDB_G0267438", "Q8T6J2", "DDB_G0274119" ] }, "reaction_10590231": { "compartment": "compartment_17947", "id": "reaction_10590231", "reactome": "R-DDI-382613", "name": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590229", "species_10590211" ], "products": [ "species_10590203", "species_10590227", "species_10590211" ], "modifiers": [], "additional_components": [ "Q555I0", "DDB_G0274873", "Q8T8P3", "DDB_G0293194", "DDB_G0281213", "Q8T8P3", "DDB_G0293194", "DDB_G0274873", "DDB_G0281213" ] }, "reaction_10589110": { "compartment": "compartment_876", "id": "reaction_10589110", "reactome": "R-DDI-265783", "name": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_265784", "species_113592" ], "products": [ "species_29372", "species_29370", "species_265781" ], "modifiers": [ [ "species_10589107", "catalyst" ] ], "additional_components": [ "CHEBI:26125", "species_216762", "CHEBI:26125", "species_216762", "Q54T02", "DDB_G0282103", "Q86HQ2", "DDB_G0274117", "Q8T685", "DDB_G0274115", "Q55DA0", "DDB_G0270826", "Q55DW4", "DDB_G0269214", "Q8T686", "DDB_G0289655", "Q8T689", "DDB_G0289657" ] }, "reaction_10597819": { "compartment": "compartment_70101", "id": "reaction_10597819", "reactome": "R-DDI-1454928", "name": "ABCG4 may mediate cholesterol efflux", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176478", "species_29356", "species_113592" ], "products": [ "species_171149", "species_29372", "species_29370" ], "modifiers": [ [ "species_10597816", "catalyst" ] ], "additional_components": [ "Q8T685", "DDB_G0274115", "Q8T686", "DDB_G0289655", "Q8T689", "DDB_G0289657", "Q54T02", "DDB_G0282103", "Q55DA0", "DDB_G0270826", "Q55DW4", "DDB_G0269214", "Q86HQ2", "DDB_G0274117" ] }, "reaction_10597674": { "compartment": "compartment_876", "id": "reaction_10597674", "reactome": "R-DDI-1369028", "name": "ABCAs mediate lipid efflux", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_176478", "species_113592" ], "products": [ "species_171149", "species_29372", "species_29370" ], "modifiers": [ [ "species_10597671", "catalyst" ] ], "additional_components": [] }, "reaction_10597676": { "compartment": "compartment_876", "id": "reaction_10597676", "reactome": "R-DDI-1369052", "name": "ABCAs mediate lipid influx", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_171149", "species_29356", "species_113592" ], "products": [ "species_29372", "species_176478", "species_29370" ], "modifiers": [ [ "species_10597671", "catalyst" ] ], "additional_components": [] }, "reaction_10607964": { "compartment": "compartment_70101", "id": "reaction_10607964", "reactome": "R-DDI-5682285", "name": "ABCA12 transports lipids from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5682283", "species_29356", "species_113592" ], "products": [ "species_29372", "species_29370", "species_5229279" ], "modifiers": [ [ "species_10607961", "catalyst" ] ], "additional_components": [ "Q8T5Z7", "DDB_G0291994", "Q8T6J1", "DDB_G0291245", "Q8T6J2", "DDB_G0274119", "Q8T6J5", "DDB_G0267438", "Q54BT5", "DDB_G0293436", "Q555Z5", "DDB_G0274121", "Q55BC0", "DDB_G0271138" ] }, "reaction_10590206": { "compartment": "compartment_17947", "id": "reaction_10590206", "reactome": "R-DDI-382575", "name": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_382577" ], "products": [ "species_382571", "species_29372", "species_29370" ], "modifiers": [ [ "species_10590203", "catalyst" ] ], "additional_components": [ "Q8T8P3", "DDB_G0293194" ] }, "reaction_10590246": { "compartment": "compartment_876", "id": "reaction_10590246", "reactome": "R-DDI-383190", "name": "HCO3- transport through ion channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111627", "species_113592" ], "products": [ "species_29372", "species_29370", "species_425425" ], "modifiers": [ [ "species_10590243", "catalyst" ] ], "additional_components": [ "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q54LE6", "DDB_G0286559", "Q54P13", "DDB_G0284867", "Q54U44", "DDB_G0280973" ] }, "reaction_10597798": { "compartment": "compartment_70101", "id": "reaction_10597798", "reactome": "R-DDI-1454916", "name": "The ABCC family mediates organic anion transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_1454930" ], "products": [ "species_29372", "species_29370", "species_1454919" ], "modifiers": [ [ "species_10597795", "catalyst" ] ], "additional_components": [ "Q54EK2", "DDB_G0291243", "Q54K24", "DDB_G0287589", "Q54NL1", "DDB_G0285165", "Q54V86", "DDB_G0280539", "Q54VC1", "DDB_G0280459", "Q54VJ0", "DDB_G0280055", "Q8T6H3", "DDB_G0287593", "Q8T6H8", "DDB_G0280541", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q54LE6", "DDB_G0286559", "Q54P13", "DDB_G0284867", "Q54U44", "DDB_G0280973" ] }, "reaction_10619962": { "compartment": "compartment_70101", "id": "reaction_10619962", "reactome": "R-DDI-8866553", "name": "misfolded CFTR is degraded by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619960" ], "products": [ "species_10577037" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q54U44", "DDB_G0280973", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10597848": { "compartment": "compartment_876", "id": "reaction_10597848", "reactome": "R-DDI-1467457", "name": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_1131652" ], "products": [ "species_29372", "species_29370", "species_1467459" ], "modifiers": [ [ "species_10597845", "catalyst" ] ], "additional_components": [ "Q8T9W4", "DDB_G0291714", "Q54BT3", "DDB_G0293438", "Q55BC0", "DDB_G0271138", "Q8T5Z7", "DDB_G0291994", "Q8T6J1", "DDB_G0291245", "Q8T6J2", "DDB_G0274119", "Q8T6J5", "DDB_G0267438", "Q54BT5", "DDB_G0293436", "Q555Z5", "DDB_G0274121" ] }, "reaction_10607707": { "compartment": "compartment_984", "id": "reaction_10607707", "reactome": "R-DDI-5678706", "name": "ABCB4 transports PC from plasma membrane to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429802", "species_113592" ], "products": [ "species_382539", "species_29372", "species_29370" ], "modifiers": [ [ "species_10607704", "catalyst" ] ], "additional_components": [ "Q54BT3", "DDB_G0293438", "Q8T9W4", "DDB_G0291714" ] }, "reaction_10597867": { "compartment": "compartment_74000", "id": "reaction_10597867", "reactome": "R-DDI-1467466", "name": "ABCA4 mediates atRAL transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_2466098" ], "products": [ "species_29372", "species_29370", "species_975622" ], "modifiers": [ [ "species_10597864", "catalyst" ] ], "additional_components": [ "Q8T5Z7", "DDB_G0291994", "Q8T6J1", "DDB_G0291245", "Q8T6J2", "DDB_G0274119", "Q8T6J5", "DDB_G0267438", "Q54BT5", "DDB_G0293436", "Q555Z5", "DDB_G0274121", "Q55BC0", "DDB_G0271138" ] }, "reaction_10604826": { "compartment": "compartment_70101", "id": "reaction_10604826", "reactome": "R-DDI-5227009", "name": "ABCF1 binds EIF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604822", "species_10580002" ], "products": [ "species_10604824" ], "modifiers": [], "additional_components": [ "DDB_G0267436", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "Q8T6B4", "DDB_G0267436" ] }, "reaction_10607710": { "compartment": "compartment_70101", "id": "reaction_10607710", "reactome": "R-DDI-5678863", "name": "CFTR transports Cl- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_352022" ], "products": [ "species_188972", "species_29372", "species_29370" ], "modifiers": [ [ "species_10590243", "catalyst" ] ], "additional_components": [ "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q54LE6", "DDB_G0286559", "Q54P13", "DDB_G0284867", "Q54U44", "DDB_G0280973" ] }, "reaction_10584149": { "compartment": "compartment_70101", "id": "reaction_10584149", "reactome": "R-DDI-165162", "name": "Phosphorylation of TSC2 by PKB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584141", "species_113592" ], "products": [ "species_29370", "species_10584146" ], "modifiers": [ [ "species_10582598", "catalyst" ] ], "additional_components": [ "DDB_G0280527", "DDB_G0280527", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_179838" ] }, "reaction_10624166": { "compartment": "compartment_876", "id": "reaction_10624166", "reactome": "R-DDI-8981353", "name": "RASA1 stimulates RAS GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624163" ], "products": [ "species_10585895", "species_10585874" ], "modifiers": [ [ "species_10624163", "catalyst" ] ], "additional_components": [ "Q54Q13", "DDB_G0284177", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "DDB_G0284177", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29420", "Q54Q13", "DDB_G0284177", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438" ] }, "reaction_10624168": { "compartment": "compartment_876", "id": "reaction_10624168", "reactome": "R-DDI-8981355", "name": "RASA1 binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585144", "species_10585895" ], "products": [ "species_10624163" ], "modifiers": [], "additional_components": [ "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "DDB_G0284177", "Q54Q13", "DDB_G0284177", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438" ] }, "reaction_10617858": { "compartment": "compartment_263163", "id": "reaction_10617858", "reactome": "R-DDI-6814088", "name": "SYS1 binds AcM-ARFRP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617856", "species_10617826" ], "products": [ "species_10617836" ], "modifiers": [], "additional_components": [ "Q54QU7", "DDB_G0283631", "species_29438", "DDB_G0269368", "Q55E69", "DDB_G0269368", "Q54QU7", "DDB_G0283631", "species_29438" ] }, "reaction_10617680": { "compartment": "compartment_263163", "id": "reaction_10617680", "reactome": "R-DDI-6811428", "name": "RIC1:RGP1 recruits RAB6:GDP to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617658", "species_10617670" ], "products": [ "species_10617678" ], "modifiers": [], "additional_components": [ "Q55FK2", "DDB_G0268068", "species_29420", "Q54WR7", "DDB_G0279477", "Q76NU4", "DDB_G0277397", "Q54WR7", "DDB_G0279477", "Q76NU4", "DDB_G0277397", "Q55FK2", "DDB_G0268068", "species_29420" ] }, "reaction_10618272": { "compartment": "compartment_263163", "id": "reaction_10618272", "reactome": "R-DDI-6814678", "name": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618267", "species_113592" ], "products": [ "species_10611694", "species_10618041", "species_10617977", "species_29370", "species_10611703", "species_10617975", "species_10617985" ], "modifiers": [ [ "species_10618267", "catalyst" ] ], "additional_components": [ "Q54CK6", "DDB_G0292974", "Q553C3", "DDB_G0275765", "Q54R67", "DDB_G0283363", "Q54I20", "DDB_G0289063", "Q551H5", "DDB_G0276575", "Q54GB3", "DDB_G0290363", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153", "Q75JI3", "DDB_G0276153", "DDB_G0290363", "DDB_G0276575", "Q54NP6", "DDB_G0285111", "DDB_G0289063", "Q54CK6", "DDB_G0292974", "Q553C3", "DDB_G0275765", "Q54R67", "DDB_G0283363", "Q54CK6", "DDB_G0292974", "Q553C3", "DDB_G0275765", "Q54R67", "DDB_G0283363", "Q54I20", "DDB_G0289063", "Q551H5", "DDB_G0276575", "Q54GB3", "DDB_G0290363", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153" ] }, "reaction_10617687": { "compartment": "compartment_263163", "id": "reaction_10617687", "reactome": "R-DDI-6811429", "name": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10617678" ], "products": [ "species_29420", "species_10617684" ], "modifiers": [ [ "species_10617678", "catalyst" ] ], "additional_components": [ "Q54WR7", "DDB_G0279477", "Q76NU4", "DDB_G0277397", "Q55FK2", "DDB_G0268068", "species_29420", "Q55FK2", "DDB_G0268068", "species_29438", "Q54WR7", "DDB_G0279477", "Q76NU4", "DDB_G0277397", "Q54WR7", "DDB_G0279477", "Q76NU4", "DDB_G0277397", "Q55FK2", "DDB_G0268068", "species_29420" ] }, "reaction_10618359": { "compartment": "compartment_263163", "id": "reaction_10618359", "reactome": "R-DDI-8847537", "name": "RAB43:GTP binds USP8NL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618357", "species_10618342" ], "products": [ "species_10618344" ], "modifiers": [], "additional_components": [ "Q54Z16", "DDB_G0289735", "Q54H32", "DDB_G0289735", "Q54SD0", "DDB_G0282537", "species_29438", "Q54SD0", "DDB_G0282537", "species_29438", "Q54H32", "DDB_G0289735", "Q54Z16", "DDB_G0289735" ] }, "reaction_10618312": { "compartment": "compartment_263163", "id": "reaction_10618312", "reactome": "R-DDI-6814684", "name": "cis-SNARE binds SNAPs and NSF hexamer at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611694", "species_10611703", "species_10618308" ], "products": [ "species_10618310" ], "modifiers": [], "additional_components": [ "Q75JI3", "DDB_G0276153", "Q54NP6", "DDB_G0285111", "Q54I20", "DDB_G0289063", "Q54PW2", "DDB_G0284185", "Q54PQ5", "DDB_G0289063", "Q54CK6", "DDB_G0292974", "Q553C3", "DDB_G0275765", "Q54R67", "DDB_G0283363", "Q551H5", "DDB_G0276575", "Q54I20", "DDB_G0289063", "Q54PW2", "DDB_G0284185", "Q54PQ5", "DDB_G0289063", "Q54CK6", "DDB_G0292974", "Q553C3", "DDB_G0275765", "Q54R67", "DDB_G0283363", "Q551H5", "DDB_G0276575", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153" ] }, "reaction_10618351": { "compartment": "compartment_263163", "id": "reaction_10618351", "reactome": "R-DDI-8847534", "name": "RAB43 hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618344" ], "products": [ "species_10618348" ], "modifiers": [ [ "species_10618344", "catalyst" ] ], "additional_components": [ "Q54SD0", "DDB_G0282537", "species_29438", "Q54H32", "DDB_G0289735", "Q54Z16", "DDB_G0289735", "Q54SD0", "DDB_G0282537", "species_29420", "Q54H32", "DDB_G0289735", "Q54Z16", "DDB_G0289735", "Q54SD0", "DDB_G0282537", "species_29438", "Q54H32", "DDB_G0289735", "Q54Z16", "DDB_G0289735" ] }, "reaction_10617852": { "compartment": "compartment_263163", "id": "reaction_10617852", "reactome": "R-DDI-6814086", "name": "ARFRP1 recruits ARL1 to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617836", "species_10617844" ], "products": [ "species_10617850" ], "modifiers": [], "additional_components": [ "Q55E69", "DDB_G0269368", "Q54QU7", "DDB_G0283631", "species_29438", "Q54JB7", "DDB_G0288163", "species_29438", "Q54JB7", "DDB_G0288163", "species_29438", "Q55E69", "DDB_G0269368", "Q54QU7", "DDB_G0283631" ] }, "reaction_10617869": { "compartment": "compartment_263163", "id": "reaction_10617869", "reactome": "R-DDI-6814091", "name": "ARL1 recruits TGN Golgin homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617865", "species_10617850" ], "products": [ "species_10617867" ], "modifiers": [], "additional_components": [ "Q556B3", "DDB_G0274785", "Q54JB7", "DDB_G0288163", "species_29438", "Q55E69", "DDB_G0269368", "Q54QU7", "DDB_G0283631", "Q54JB7", "DDB_G0288163", "species_29438", "Q55E69", "DDB_G0269368", "Q54QU7", "DDB_G0283631", "Q556B3", "DDB_G0274785" ] }, "reaction_10618269": { "compartment": "compartment_263163", "id": "reaction_10618269", "reactome": "R-DDI-6814676", "name": "SNAPs and NSF hexamer bind cis-SNARE at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611694", "species_10611703", "species_10618103" ], "products": [ "species_10618267" ], "modifiers": [], "additional_components": [ "Q75JI3", "DDB_G0276153", "Q54NP6", "DDB_G0285111", "Q54CK6", "DDB_G0292974", "Q553C3", "DDB_G0275765", "Q54R67", "DDB_G0283363", "Q54I20", "DDB_G0289063", "Q551H5", "DDB_G0276575", "Q54GB3", "DDB_G0290363", "Q54CK6", "DDB_G0292974", "Q553C3", "DDB_G0275765", "Q54R67", "DDB_G0283363", "Q54I20", "DDB_G0289063", "Q551H5", "DDB_G0276575", "Q54GB3", "DDB_G0290363", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153" ] }, "reaction_10623407": { "compartment": "compartment_70616", "id": "reaction_10623407", "reactome": "R-DDI-8949178", "name": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8949232" ], "products": [ "species_8949220" ], "modifiers": [ [ "species_10623404", "catalyst" ] ], "additional_components": [ "Q54JS1", "DDB_G0287825", "Q54LT0", "DDB_G0286429" ] }, "reaction_10592489": { "compartment": "compartment_876", "id": "reaction_10592489", "reactome": "R-DDI-442422", "name": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10592486", "catalyst" ] ], "additional_components": [ "Q55EA1", "DDB_G0269326", "Q54MB9", "DDB_G0286049" ] }, "reaction_10583681": { "compartment": "compartment_7660", "id": "reaction_10583681", "reactome": "R-DDI-156678", "name": "Activation of Cdc25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10583669" ], "products": [ "species_29370", "species_10583672" ], "modifiers": [ [ "species_10583678", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "DDB_G0274503" ] }, "reaction_10583700": { "compartment": "compartment_7660", "id": "reaction_10583700", "reactome": "R-DDI-156699", "name": "Inactivation of Wee1 kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10577525" ], "products": [ "species_113582", "species_10583695" ], "modifiers": [ [ "species_10583697", "catalyst" ] ], "additional_components": [ "DDB_G0277539", "DDB_G0277539", "DDB_G0274503" ] }, "reaction_10583863": { "compartment": "compartment_7660", "id": "reaction_10583863", "reactome": "R-DDI-162657", "name": "Inactivation of Myt1 kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10583858" ], "products": [ "species_113582", "species_10583861" ], "modifiers": [ [ "species_10583697", "catalyst" ] ], "additional_components": [ "DDB_G0291133", "DDB_G0291133", "DDB_G0274503" ] }, "reaction_10600890": { "compartment": "compartment_984", "id": "reaction_10600890", "reactome": "R-DDI-2328033", "name": "Fibrillin-1 binds latent TGF-beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600886", "species_10600215" ], "products": [ "species_10600888" ], "modifiers": [], "additional_components": [ "Q559U0", "DDB_G0278613", "Q54YP0", "DDB_G0278613", "Q54IA3", "DDB_G0295485", "B0G154", "DDB_G0295485", "Q54IA3", "DDB_G0295485", "B0G154", "DDB_G0295485", "Q559U0", "DDB_G0278613", "Q54YP0", "DDB_G0278613" ] }, "reaction_10600223": { "compartment": "compartment_984", "id": "reaction_10600223", "reactome": "R-DDI-2129362", "name": "Fibrillin microfibril assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600193" ], "products": [ "species_10600221" ], "modifiers": [], "additional_components": [ "Q54IA3", "DDB_G0295485", "B0G154", "DDB_G0295485", "Q54IA3", "DDB_G0295485", "B0G154", "DDB_G0295485" ] }, "reaction_10601589": { "compartment": "compartment_70101", "id": "reaction_10601589", "reactome": "R-DDI-2730896", "name": "Phosphorylation of MEK4 by MEKK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10593048" ], "products": [ "species_29370", "species_10593058" ], "modifiers": [ [ "species_10601580", "catalyst" ] ], "additional_components": [ "DDB_G0289277", "DDB_G0289277", "Q54PX0", "DDB_G0284251", "Q55CA6", "DDB_G0284251", "Q8T2I8", "DDB_G0276465" ] }, "reaction_10601583": { "compartment": "compartment_70101", "id": "reaction_10601583", "reactome": "R-DDI-2730868", "name": "Phosphorylation of MEK7 by MEKK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10593046" ], "products": [ "species_10593054", "species_29370" ], "modifiers": [ [ "species_10601580", "catalyst" ] ], "additional_components": [ "DDB_G0289277", "DDB_G0289277", "Q54PX0", "DDB_G0284251", "Q55CA6", "DDB_G0284251", "Q8T2I8", "DDB_G0276465" ] }, "reaction_10626182": { "compartment": "compartment_70101", "id": "reaction_10626182", "reactome": "R-DDI-9619355", "name": "CaMKK autophosphorylates in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626175", "species_113592" ], "products": [ "species_29370", "species_10626179" ], "modifiers": [ [ "species_10626175", "catalyst" ] ], "additional_components": [ "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "Q55CW1", "DDB_G0270680", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "Q55CW1", "DDB_G0270680", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "Q55CW1", "DDB_G0270680" ] }, "reaction_10626191": { "compartment": "compartment_70101", "id": "reaction_10626191", "reactome": "R-DDI-9619376", "name": "CAMK1 binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626187", "species_10583042" ], "products": [ "species_10626189" ], "modifiers": [], "additional_components": [ "DDB_G0279925", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "P25323", "DDB_G0279925" ] }, "reaction_10585189": { "compartment": "compartment_70101", "id": "reaction_10585189", "reactome": "R-DDI-174054", "name": "Formation of Cyclin A:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577493", "species_10584819" ], "products": [ "species_10585187" ], "modifiers": [], "additional_components": [ "DDB_G0272813", "P34112", "DDB_G0272813" ] }, "reaction_10585460": { "compartment": "compartment_13231", "id": "reaction_10585460", "reactome": "R-DDI-174273", "name": "Translocation of Cyclin A:Cdk2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585187" ], "products": [ "species_10585380" ], "modifiers": [], "additional_components": [ "P34112", "DDB_G0272813", "P34112", "DDB_G0272813" ] }, "reaction_10585924": { "compartment": "compartment_7660", "id": "reaction_10585924", "reactome": "R-DDI-187948", "name": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10585920" ], "products": [ "species_113582", "species_10585922" ], "modifiers": [ [ "species_10576705", "catalyst" ] ], "additional_components": [ "Q54FX2", "DDB_G0290551", "Q54KM3", "DDB_G0287259", "Q54FX2", "DDB_G0290551", "Q54KM3", "DDB_G0287259", "P34112", "DDB_G0272813" ] }, "reaction_10585927": { "compartment": "compartment_7660", "id": "reaction_10585927", "reactome": "R-DDI-187949", "name": "CAK-mediated phosphorylation of Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10585380" ], "products": [ "species_113582", "species_10576705" ], "modifiers": [ [ "species_10580662", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "P34112", "DDB_G0272813", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668" ] }, "reaction_10585382": { "compartment": "compartment_7660", "id": "reaction_10585382", "reactome": "R-DDI-174110", "name": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10585378" ], "products": [ "species_113550", "species_10585380" ], "modifiers": [ [ "species_10577539", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "P34112", "DDB_G0272813", "DDB_G0283617" ] }, "reaction_10585914": { "compartment": "compartment_7660", "id": "reaction_10585914", "reactome": "R-DDI-187574", "name": "Degradation of ubiquitinated p27/p21 by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585912" ], "products": [ "species_10577273", "species_10585908", "species_10576865" ], "modifiers": [ [ "species_10585327", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "B0G102", "DDB_G0271642", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "B0G102", "DDB_G0271642", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q27563", "DDB_G0267408", "P02889", "DDB_G0272564", "P34119", "DDB_G0280969", "Q552Y8", "DDB_G0275753", "Q55G04", "DDB_G0268538", "Q967U1", "DDB_G0285099", "Q54XM7", "DDB_G0278847", "P34120", "DDB_G0272831", "Q86A21", "DDB_G0272969", "Q54S82", "DDB_G0282617", "Q54QR2", "DDB_G0283679", "Q55DY7", "DDB_G0269472", "Q55D66", "DDB_G0269772", "Q556Q0", "DDB_G0273163", "Q54BC8", "DDB_G0293784", "Q55GJ6", "DDB_G0267390", "Q55BV5", "DDB_G0270784", "Q86JA1", "DDB_G0276917", "Q54PN7", "DDB_G0284415", "P34123", "DDB_G0289003", "P34124", "DDB_G0292382", "Q54PJ1", "DDB_G0284517", "Q54JM5", "DDB_G0287953", "Q54HW1", "DDB_G0289189", "Q54UB5", "DDB_G0281315", "Q54UJ0", "DDB_G0281051", "Q54NQ0", "DDB_G0285105", "Q54BC6", "DDB_G0293752", "Q1ZXD3", "DDB_G0288621", "Q553E0", "DDB_G0275775", "Q86IJ1", "DDB_G0272566", "Q559F4", "DDB_G0272951", "Q27562", "DDB_G0282363", "Q55C75", "DDB_G0270188", "Q54DM7", "DDB_G0292122", "Q54WI8", "DDB_G0279633" ] }, "reaction_10585439": { "compartment": "compartment_7660", "id": "reaction_10585439", "reactome": "R-DDI-174164", "name": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10585380" ], "products": [ "species_113582", "species_10585378" ], "modifiers": [ [ "species_10577525", "catalyst" ], [ "species_10577531", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "P34112", "DDB_G0272813", "DDB_G0277539", "DDB_G0302543" ] }, "reaction_10601123": { "compartment": "compartment_7660", "id": "reaction_10601123", "reactome": "R-DDI-2468039", "name": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601103", "species_113560" ], "products": [ "species_2485002", "species_10601111" ], "modifiers": [ [ "species_10601120", "catalyst" ] ], "additional_components": [ "Q54QR0", "DDB_G0283681", "Q54E85", "DDB_G0291752", "Q552D9", "DDB_G0276101", "Q550H7", "DDB_G0276977", "Q552Q7", "DDB_G0275929", "Q54QR0", "DDB_G0283681", "Q552D9", "DDB_G0276101", "Q54E85", "DDB_G0291752", "Q550H7", "DDB_G0276977", "Q552Q7", "DDB_G0275929", "Q54W25", "DDB_G0279959" ] }, "reaction_10601155": { "compartment": "compartment_7660", "id": "reaction_10601155", "reactome": "R-DDI-2473152", "name": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601151", "species_113560" ], "products": [ "species_2485002", "species_10601153" ], "modifiers": [ [ "species_10601120", "catalyst" ] ], "additional_components": [ "Q54QR0", "DDB_G0283681", "Q54E85", "DDB_G0291752", "Q552D9", "DDB_G0276101", "Q550H7", "DDB_G0276977", "Q552Q7", "DDB_G0275929", "Q54QR0", "DDB_G0283681", "Q552D9", "DDB_G0276101", "Q54E85", "DDB_G0291752", "Q550H7", "DDB_G0276977", "Q552Q7", "DDB_G0275929", "Q54W25", "DDB_G0279959" ] }, "reaction_10585939": { "compartment": "compartment_7660", "id": "reaction_10585939", "reactome": "R-DDI-187959", "name": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10585916" ], "products": [ "species_113582", "species_10585936" ], "modifiers": [ [ "species_10585916", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q54Q23", "DDB_G0284129", "P34112", "DDB_G0272813", "Q54Q23", "DDB_G0284129", "P34112", "DDB_G0272813", "Q54Q23", "DDB_G0284129" ] }, "reaction_10585918": { "compartment": "compartment_7660", "id": "reaction_10585918", "reactome": "R-DDI-187937", "name": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576524", "species_10576705" ], "products": [ "species_10585916" ], "modifiers": [], "additional_components": [ "Q54Q23", "DDB_G0284129", "P34112", "DDB_G0272813", "P34112", "DDB_G0272813", "Q54Q23", "DDB_G0284129" ] }, "reaction_10619259": { "compartment": "compartment_70101", "id": "reaction_10619259", "reactome": "R-DDI-8854041", "name": "SCF-FBXL7 ubiquitinates AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10619191" ], "products": [ "species_10619256" ], "modifiers": [ [ "species_10619191", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54WX4", "DDB_G0279343", "Q54WX4", "DDB_G0279343", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54WX4", "DDB_G0279343" ] }, "reaction_10619193": { "compartment": "compartment_70101", "id": "reaction_10619193", "reactome": "R-DDI-8853496", "name": "SCF:FBXL7 binds AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585350", "species_10619189" ], "products": [ "species_10619191" ], "modifiers": [], "additional_components": [ "DDB_G0279343", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54WX4", "DDB_G0279343" ] }, "reaction_10619261": { "compartment": "compartment_70101", "id": "reaction_10619261", "reactome": "R-DDI-8854044", "name": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619256" ], "products": [ "species_10577037", "species_10619189" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q54WX4", "DDB_G0279343", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10584837": { "compartment": "compartment_13231", "id": "reaction_10584837", "reactome": "R-DDI-170159", "name": "Translocation of Cdc25 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584833" ], "products": [ "species_10584835" ], "modifiers": [], "additional_components": [ "Q54QM6", "DDB_G0283617", "Q54QM6", "DDB_G0283617" ] }, "reaction_10619653": { "compartment": "compartment_7660", "id": "reaction_10619653", "reactome": "R-DDI-8856951", "name": "PP2A demethylation by PPME1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10619637" ], "products": [ "species_10597550", "species_8857797" ], "modifiers": [ [ "species_10619650", "catalyst" ] ], "additional_components": [ "DDB_G0281651" ] }, "reaction_10584825": { "compartment": "compartment_13231", "id": "reaction_10584825", "reactome": "R-DDI-170120", "name": "Translocation of Cdc25B to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584821" ], "products": [ "species_10584823" ], "modifiers": [], "additional_components": [ "DDB_G0283617", "DDB_G0283617" ] }, "reaction_10584829": { "compartment": "compartment_13231", "id": "reaction_10584829", "reactome": "R-DDI-170149", "name": "Translocation of active Cdc25C to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583672" ], "products": [ "species_10584827" ], "modifiers": [], "additional_components": [ "DDB_G0283617", "DDB_G0283617" ] }, "reaction_10619645": { "compartment": "compartment_7660", "id": "reaction_10619645", "reactome": "R-DDI-8856945", "name": "PP2A methylation by LCMT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597550", "species_77087" ], "products": [ "species_77502", "species_10619637" ], "modifiers": [ [ "species_10619642", "catalyst" ] ], "additional_components": [ "DDB_G0288271" ] }, "reaction_10601941": { "compartment": "compartment_70101", "id": "reaction_10601941", "reactome": "R-DDI-3002798", "name": "Cytosolic PLK1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583678" ], "products": [ "species_10583697" ], "modifiers": [], "additional_components": [ "DDB_G0274503", "DDB_G0274503" ] }, "reaction_10601061": { "compartment": "compartment_70101", "id": "reaction_10601061", "reactome": "R-DDI-2467775", "name": "Autocleavage of ESPL1 (Separase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601050" ], "products": [ "species_10601058" ], "modifiers": [ [ "species_10601050", "catalyst" ] ], "additional_components": [ "DDB_G0290325", "Q54G81", "DDB_G0290325", "DDB_G0290325" ] }, "reaction_10600560": { "compartment": "compartment_7660", "id": "reaction_10600560", "reactome": "R-DDI-2168079", "name": "MASTL (GWL) phosphorylates ARPP19", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10600546" ], "products": [ "species_113582", "species_10600549" ], "modifiers": [ [ "species_10600557", "catalyst" ] ], "additional_components": [ "DDB_G0283571", "DDB_G0283571", "DDB_G0272282" ] }, "reaction_10600987": { "compartment": "compartment_7660", "id": "reaction_10600987", "reactome": "R-DDI-2430535", "name": "MASTL phosphorylates ENSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10600982" ], "products": [ "species_113582", "species_10600985" ], "modifiers": [ [ "species_10600557", "catalyst" ] ], "additional_components": [ "DDB_G0283571", "DDB_G0283571", "DDB_G0272282" ] }, "reaction_10600815": { "compartment": "compartment_20699", "id": "reaction_10600815", "reactome": "R-DDI-2214351", "name": "PLK1 phosphorylates GORASP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10600807" ], "products": [ "species_10600812", "species_29370" ], "modifiers": [ [ "species_10600807", "catalyst" ] ], "additional_components": [ "P34139", "DDB_G0283757", "species_29438", "Q54C46", "DDB_G0293248", "Q86HN7", "DDB_G0274503", "P34139", "DDB_G0283757", "species_29438", "Q54C46", "DDB_G0293248", "Q86HN7", "DDB_G0274503", "P34139", "DDB_G0283757", "species_29438", "Q54C46", "DDB_G0293248", "Q86HN7", "DDB_G0274503" ] }, "reaction_10585968": { "compartment": "compartment_7660", "id": "reaction_10585968", "reactome": "R-DDI-188390", "name": "Cyclin E:CDK2-mediated phosphorylation of RB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10585963" ], "products": [ "species_113582", "species_10577271", "species_10583328" ], "modifiers": [ [ "species_10585963", "catalyst" ] ], "additional_components": [ "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "P34112", "DDB_G0272813", "Q54FX2", "DDB_G0290551", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "P34112", "DDB_G0272813", "DDB_G0290551", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "P34112", "DDB_G0272813", "Q54FX2", "DDB_G0290551" ] }, "reaction_10577511": { "compartment": "compartment_70101", "id": "reaction_10577511", "reactome": "R-DDI-69191", "name": "Formation of Cyclin E:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577493", "species_10577507" ], "products": [ "species_10577509" ], "modifiers": [], "additional_components": [ "DDB_G0272813", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "P34112", "DDB_G0272813" ] }, "reaction_10585959": { "compartment": "compartment_7660", "id": "reaction_10585959", "reactome": "R-DDI-188350", "name": "CAK-mediated phosphorylation of Cyclin E:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10577515" ], "products": [ "species_113582", "species_10577271" ], "modifiers": [ [ "species_10580662", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "P34112", "DDB_G0272813", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668" ] }, "reaction_10577542": { "compartment": "compartment_7660", "id": "reaction_10577542", "reactome": "R-DDI-69199", "name": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10577520" ], "products": [ "species_113550", "species_10577515" ], "modifiers": [ [ "species_10577539", "catalyst" ] ], "additional_components": [ "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "P34112", "DDB_G0272813", "P34112", "DDB_G0272813", "DDB_G0283617" ] }, "reaction_10577533": { "compartment": "compartment_7660", "id": "reaction_10577533", "reactome": "R-DDI-69195", "name": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10577515" ], "products": [ "species_113582", "species_10577520" ], "modifiers": [ [ "species_10577525", "catalyst" ], [ "species_10577531", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "P34112", "DDB_G0272813", "DDB_G0277539", "DDB_G0302543" ] }, "reaction_10585965": { "compartment": "compartment_7660", "id": "reaction_10585965", "reactome": "R-DDI-188386", "name": "Association of Rb with Cyclin E:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577550", "species_10577271" ], "products": [ "species_10585963" ], "modifiers": [], "additional_components": [ "DDB_G0290551", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "P34112", "DDB_G0272813", "Q54FX2", "DDB_G0290551" ] }, "reaction_10583775": { "compartment": "compartment_13231", "id": "reaction_10583775", "reactome": "R-DDI-157906", "name": "Translocation of Cyclin E:Cdk2 complex to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577509" ], "products": [ "species_10577515" ], "modifiers": [], "additional_components": [ "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "P34112", "DDB_G0272813", "P34112", "DDB_G0272813" ] }, "reaction_10583356": { "compartment": "compartment_7660", "id": "reaction_10583356", "reactome": "R-DDI-113503", "name": "PP2A mediated localization of RB1 protein in chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_113656", "species_10583328" ], "products": [ "species_113550", "species_10583330" ], "modifiers": [ [ "species_10583353", "catalyst" ] ], "additional_components": [ "DDB_G0290551", "Q54FX2", "DDB_G0290551", "Q54W95", "DDB_G0279813" ] }, "reaction_10583358": { "compartment": "compartment_7660", "id": "reaction_10583358", "reactome": "R-DDI-113504", "name": "Detection of damage during initiation of DNA synthesis in S-phase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577245" ], "products": [ "species_10576604", "species_113656" ], "modifiers": [], "additional_components": [ "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731" ] }, "reaction_10627090": { "compartment": "compartment_70101", "id": "reaction_10627090", "reactome": "R-DDI-9659820", "name": "RB1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627088" ], "products": [ "species_10577547" ], "modifiers": [], "additional_components": [ "DDB_G0290551", "DDB_G0290551" ] }, "reaction_10625026": { "compartment": "compartment_7660", "id": "reaction_10625026", "reactome": "R-DDI-9018017", "name": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577547", "species_10602086" ], "products": [ "species_10625024" ], "modifiers": [ [ "species_10577271", "inhibitor" ] ], "additional_components": [ "DDB_G0290551", "Q54Q23", "DDB_G0284129", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "Q7KWP1", "DDB_G0276799", "Q54FX2", "DDB_G0290551", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "P34112", "DDB_G0272813" ] }, "reaction_10597553": { "compartment": "compartment_7660", "id": "reaction_10597553", "reactome": "R-DDI-1363274", "name": "Dephosphorylation of p107 (RBL1) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10597263" ], "products": [ "species_113550", "species_10597255" ], "modifiers": [ [ "species_10597550", "catalyst" ] ], "additional_components": [ "DDB_G0290551", "DDB_G0290551" ] }, "reaction_10597584": { "compartment": "compartment_7660", "id": "reaction_10597584", "reactome": "R-DDI-1363331", "name": "Ubiquitination of p130 (RBL2) by SCF (Skp2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597577", "species_10576865" ], "products": [ "species_10597581", "species_10585908" ], "modifiers": [ [ "species_10597577", "catalyst" ] ], "additional_components": [ "Q54FX2", "DDB_G0290551", "B0G102", "DDB_G0271642", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54FX2", "DDB_G0290551", "B0G102", "DDB_G0271642", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54FX2", "DDB_G0290551", "B0G102", "DDB_G0271642", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972" ] }, "reaction_10597555": { "compartment": "compartment_7660", "id": "reaction_10597555", "reactome": "R-DDI-1363276", "name": "Dephosphorylation of p130 (RBL2) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10597251" ], "products": [ "species_113550", "species_10597229" ], "modifiers": [ [ "species_10597550", "catalyst" ] ], "additional_components": [ "DDB_G0290551", "DDB_G0290551" ] }, "reaction_10597579": { "compartment": "compartment_7660", "id": "reaction_10597579", "reactome": "R-DDI-1363328", "name": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585908", "species_10597251" ], "products": [ "species_10597577" ], "modifiers": [], "additional_components": [ "B0G102", "DDB_G0271642", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "DDB_G0290551", "Q54FX2", "DDB_G0290551", "B0G102", "DDB_G0271642", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972" ] }, "reaction_10600926": { "compartment": "compartment_984", "id": "reaction_10600926", "reactome": "R-DDI-2396337", "name": "HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600922", "species_10598295" ], "products": [ "species_10600924" ], "modifiers": [], "additional_components": [ "Q54LD6", "DDB_G0286691", "DDB_G0270488", "Q55E77", "DDB_G0270488", "Q54LD6", "DDB_G0286691" ] }, "reaction_10603454": { "compartment": "compartment_984", "id": "reaction_10603454", "reactome": "R-DDI-4084505", "name": "Laminins bind HSPG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603450", "species_10598295" ], "products": [ "species_10603452" ], "modifiers": [], "additional_components": [ "Q55E77", "DDB_G0270488", "DDB_G0270488", "Q55E77", "DDB_G0270488" ] }, "reaction_10626256": { "compartment": "compartment_876", "id": "reaction_10626256", "reactome": "R-DDI-9625814", "name": "SPHK1 phosphorylates sphingosine in response to E2 stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1606609" ], "products": [ "species_5218688" ], "modifiers": [ [ "species_10590508", "catalyst" ] ], "additional_components": [ "DDB_G0284545" ] }, "reaction_10582777": { "compartment": "compartment_7660", "id": "reaction_10582777", "reactome": "R-DDI-110322", "name": "Formation of Pol zeta complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582773", "species_10582768" ], "products": [ "species_10582775" ], "modifiers": [], "additional_components": [ "DDB_G0282747", "DDB_G0271608", "Q55AZ3", "DDB_G0271608", "Q54S00", "DDB_G0282747" ] }, "reaction_10594097": { "compartment": "compartment_70101", "id": "reaction_10594097", "reactome": "R-DDI-727767", "name": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727746" ], "products": [ "species_727782" ], "modifiers": [ [ "species_10594084", "catalyst" ] ], "additional_components": [ "species_83909", "species_83921", "CHEBI:16750", "CHEBI:16704", "species_83928", "CHEBI:17562", "species_5635947", "species_83909", "species_83921", "CHEBI:16704", "CHEBI:16750", "CHEBI:17562", "species_83928", "species_5635947", "Q54TT2", "DDB_G0283439", "Q54TT3", "DDB_G0283439", "Q54R17", "DDB_G0283439" ] }, "reaction_10594099": { "compartment": "compartment_70101", "id": "reaction_10594099", "reactome": "R-DDI-727768", "name": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727737" ], "products": [ "species_727774" ], "modifiers": [ [ "species_10594073", "catalyst" ] ], "additional_components": [ "species_159362", "CHEBI:28918", "species_83909", "species_209914", "species_209789", "species_209789", "species_83909", "species_209914", "species_159362", "CHEBI:28918", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0283439", "Q54TT3", "DDB_G0283439" ] }, "reaction_10582532": { "compartment": "compartment_70101", "id": "reaction_10582532", "reactome": "R-DDI-109534", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179743" ], "products": [ "species_179737" ], "modifiers": [ [ "species_10582529", "catalyst" ] ], "additional_components": [ "species_83909", "species_83921", "CHEBI:16750", "CHEBI:16704", "species_83928", "CHEBI:17562", "species_83921", "CHEBI:16750", "CHEBI:16704", "species_83928", "species_83909", "CHEBI:17562", "Q54R17", "DDB_G0283439" ] }, "reaction_10582534": { "compartment": "compartment_70101", "id": "reaction_10582534", "reactome": "R-DDI-109536", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179737" ], "products": [ "species_179743" ], "modifiers": [ [ "species_10582529", "catalyst" ] ], "additional_components": [ "species_83921", "CHEBI:16750", "CHEBI:16704", "species_83928", "species_83909", "CHEBI:17562", "species_83909", "species_83921", "CHEBI:16750", "CHEBI:16704", "species_83928", "CHEBI:17562", "Q54R17", "DDB_G0283439" ] }, "reaction_10584043": { "compartment": "compartment_70616", "id": "reaction_10584043", "reactome": "R-DDI-163215", "name": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_113593" ], "products": [ "species_113581", "species_113592" ], "modifiers": [ [ "species_10584040", "catalyst" ] ], "additional_components": [ "O97470", "DDB_G0267454" ] }, "reaction_10582525": { "compartment": "compartment_70101", "id": "reaction_10582525", "reactome": "R-DDI-109527", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179747" ], "products": [ "species_179742" ], "modifiers": [ [ "species_10582522", "catalyst" ] ], "additional_components": [ "species_83921", "CHEBI:16750", "species_83956", "CHEBI:16704", "species_83928", "species_113599", "species_83909", "species_83960", "species_29554", "species_5635947", "CHEBI:17562", "CHEBI:16040", "species_83909", "CHEBI:16040", "species_83956", "species_83921", "CHEBI:16750", "CHEBI:16704", "species_83928", "species_83960", "species_29554", "CHEBI:17562", "species_5635947", "species_113599", "Q54TT3", "DDB_G0283439", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0283439" ] }, "reaction_10594076": { "compartment": "compartment_70101", "id": "reaction_10594076", "reactome": "R-DDI-727740", "name": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727774" ], "products": [ "species_727737" ], "modifiers": [ [ "species_10594073", "catalyst" ] ], "additional_components": [ "species_209789", "species_83909", "species_209914", "species_159362", "CHEBI:28918", "species_159362", "CHEBI:28918", "species_83909", "species_209914", "species_209789", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0283439", "Q54TT3", "DDB_G0283439" ] }, "reaction_10582527": { "compartment": "compartment_70101", "id": "reaction_10582527", "reactome": "R-DDI-109529", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179742" ], "products": [ "species_179747" ], "modifiers": [ [ "species_10582522", "catalyst" ] ], "additional_components": [ "species_83909", "CHEBI:16040", "species_83956", "species_83921", "CHEBI:16750", "CHEBI:16704", "species_83928", "species_83960", "species_29554", "CHEBI:17562", "species_5635947", "species_113599", "species_83921", "CHEBI:16750", "species_83956", "CHEBI:16704", "species_83928", "species_113599", "species_83909", "species_83960", "species_29554", "species_5635947", "CHEBI:17562", "CHEBI:16040", "Q54TT3", "DDB_G0283439", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0283439" ] }, "reaction_10594129": { "compartment": "compartment_20699", "id": "reaction_10594129", "reactome": "R-DDI-742354", "name": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162756" ], "products": [ "species_914003" ], "modifiers": [ [ "species_10594126", "catalyst" ] ], "additional_components": [ "DDB_G0275061" ] }, "reaction_10594132": { "compartment": "compartment_20699", "id": "reaction_10594132", "reactome": "R-DDI-742373", "name": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742353" ], "products": [ "species_742361" ], "modifiers": [ [ "species_10594126", "catalyst" ] ], "additional_components": [ "DDB_G0275061" ] }, "reaction_10594095": { "compartment": "compartment_20699", "id": "reaction_10594095", "reactome": "R-DDI-727759", "name": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183" ], "products": [ "species_727753" ], "modifiers": [ [ "species_10594092", "catalyst" ] ], "additional_components": [ "DDB_G0278059" ] }, "reaction_10620690": { "compartment": "compartment_876", "id": "reaction_10620690", "reactome": "R-DDI-8870354", "name": "SLC36A4 transports extracellular L-Pro to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352033" ], "products": [ "species_113538" ], "modifiers": [ [ "species_10620684", "catalyst" ] ], "additional_components": [ "DDB_G0293074" ] }, "reaction_10589664": { "compartment": "compartment_876", "id": "reaction_10589664", "reactome": "R-DDI-375768", "name": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10589661", "catalyst" ] ], "additional_components": [ "species_29444", "species_29468", "species_29468", "species_29444", "Q54KK4", "DDB_G0346922", "Q54F04", "DDB_G0346922", "Q54KK2", "DDB_G0346922", "Q54KK5", "DDB_G0346922", "Q54W03", "DDB_G0346922", "Q54EJ9", "DDB_G0291227", "Q54KK3", "DDB_G0346922" ] }, "reaction_10589683": { "compartment": "compartment_876", "id": "reaction_10589683", "reactome": "R-DDI-375770", "name": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10589680", "catalyst" ] ], "additional_components": [ "species_29444", "species_29468", "species_29468", "species_29444", "Q54EJ9", "DDB_G0291227", "Q54F04", "DDB_G0346922", "Q54KK2", "DDB_G0346922", "Q54KK3", "DDB_G0346922", "Q54KK4", "DDB_G0346922", "Q54KK5", "DDB_G0346922", "Q54W03", "DDB_G0346922" ] }, "reaction_10589702": { "compartment": "compartment_876", "id": "reaction_10589702", "reactome": "R-DDI-375776", "name": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10589699", "catalyst" ] ], "additional_components": [ "species_29444", "species_29468", "species_29468", "species_29444", "Q54W03", "DDB_G0346922", "Q54EJ9", "DDB_G0291227", "Q54F04", "DDB_G0346922", "Q54KK2", "DDB_G0346922", "Q54KK3", "DDB_G0346922", "Q54KK4", "DDB_G0346922", "Q54KK5", "DDB_G0346922" ] }, "reaction_10589704": { "compartment": "compartment_876", "id": "reaction_10589704", "reactome": "R-DDI-375790", "name": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10589661", "catalyst" ] ], "additional_components": [ "species_29444", "species_29468", "species_29468", "species_29444", "Q54KK4", "DDB_G0346922", "Q54F04", "DDB_G0346922", "Q54KK2", "DDB_G0346922", "Q54KK5", "DDB_G0346922", "Q54W03", "DDB_G0346922", "Q54EJ9", "DDB_G0291227", "Q54KK3", "DDB_G0346922" ] }, "reaction_10624530": { "compartment": "compartment_7660", "id": "reaction_10624530", "reactome": "R-DDI-9007539", "name": "CHEK1 phosphorylates E2F6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10623848" ], "products": [ "species_113582", "species_10624528" ], "modifiers": [ [ "species_10577605", "catalyst" ] ], "additional_components": [ "DDB_G0284129", "DDB_G0284129", "DDB_G0279719" ] }, "reaction_10623920": { "compartment": "compartment_7660", "id": "reaction_10623920", "reactome": "R-DDI-8954056", "name": "E2F6 binds TFDP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597242", "species_10623848" ], "products": [ "species_10623918" ], "modifiers": [], "additional_components": [ "DDB_G0276799", "DDB_G0284129", "Q54Q23", "DDB_G0284129", "Q7KWP1", "DDB_G0276799" ] }, "reaction_10623931": { "compartment": "compartment_7660", "id": "reaction_10623931", "reactome": "R-DDI-8954117", "name": "E2F6:TFDP1 binds EPC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623850", "species_10623927" ], "products": [ "species_10623929" ], "modifiers": [], "additional_components": [ "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "DDB_G0287727", "Q54JZ0", "DDB_G0287727", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129" ] }, "reaction_10623852": { "compartment": "compartment_7660", "id": "reaction_10623852", "reactome": "R-DDI-8953111", "name": "E2F6 binds TFDP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623848", "species_10597240" ], "products": [ "species_10623850" ], "modifiers": [], "additional_components": [ "DDB_G0284129", "DDB_G0276799", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129" ] }, "reaction_10595753": { "compartment": "compartment_7660", "id": "reaction_10595753", "reactome": "R-DDI-975040", "name": "KRAB-ZNF / KAP Interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10595749", "species_10595441" ], "products": [ "species_10595751" ], "modifiers": [], "additional_components": [ "Q54UG9", "DDB_G0281085", "DDB_G0285989", "Q54MF7", "DDB_G0285989", "Q54UG9", "DDB_G0281085" ] }, "reaction_10612161": { "compartment": "compartment_7660", "id": "reaction_10612161", "reactome": "R-DDI-5696655", "name": "PARP1 or PARP2 PARylates DDB2 and autoPARylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612159", "species_427523" ], "products": [ "species_427497", "species_10611122" ], "modifiers": [], "additional_components": [ "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296", "Q54CS2", "DDB_G0292794", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820" ] }, "reaction_10612163": { "compartment": "compartment_7660", "id": "reaction_10612163", "reactome": "R-DDI-5696664", "name": "PARP1 or PARP2 binds DDB2 at GG-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612157", "species_10606233" ], "products": [ "species_10612159" ], "modifiers": [], "additional_components": [ "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296" ] }, "reaction_10611143": { "compartment": "compartment_7660", "id": "reaction_10611143", "reactome": "R-DDI-5691004", "name": "XPC binds RAD23 and CETN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603915", "species_10603976", "species_10611111" ], "products": [ "species_10611141" ], "modifiers": [], "additional_components": [ "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "DDB_G0292296", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q1ZXA6", "DDB_G0292296", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151" ] }, "reaction_10612471": { "compartment": "compartment_7660", "id": "reaction_10612471", "reactome": "R-DDI-6782943", "name": "UV-DDB ubiquitinates XPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611197", "species_10576865" ], "products": [ "species_10612157" ], "modifiers": [ [ "species_10611197", "catalyst" ] ], "additional_components": [ "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q1ZXA6", "DDB_G0292296", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q1ZXA6", "DDB_G0292296", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629" ] }, "reaction_10611199": { "compartment": "compartment_7660", "id": "reaction_10611199", "reactome": "R-DDI-5691006", "name": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611195", "species_10611141", "species_5688114" ], "products": [ "species_10611197", "species_10611193" ], "modifiers": [], "additional_components": [ "Q54PF3", "DDB_G0284597", "Q54QX3", "DDB_G0283587", "Q54HL6", "DDB_G0289361", "Q55BD5", "DDB_G0271282", "Q54E53", "DDB_G0291848", "Q54C92", "DDB_G0293180", "Q75K24", "DDB_G0275471", "Q54B82", "DDB_G0293844", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q1ZXA6", "DDB_G0292296", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q1ZXA6", "DDB_G0292296", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54PF3", "DDB_G0284597", "Q54QX3", "DDB_G0283587", "Q54HL6", "DDB_G0289361", "Q55BD5", "DDB_G0271282", "Q54E53", "DDB_G0291848", "Q54C92", "DDB_G0293180", "Q75K24", "DDB_G0275471", "Q54B82", "DDB_G0293844" ] }, "reaction_10611139": { "compartment": "compartment_7660", "id": "reaction_10611139", "reactome": "R-DDI-5691000", "name": "TFIIH binds GG-NER site to form a verification complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580699", "species_10611122" ], "products": [ "species_10611137" ], "modifiers": [], "additional_components": [ "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54CS2", "DDB_G0292794", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729" ] }, "reaction_10582642": { "compartment": "compartment_7660", "id": "reaction_10582642", "reactome": "R-DDI-109955", "name": "Formation of ERCC1:XPF heterodimeric complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582638", "species_10582633" ], "products": [ "species_10582640" ], "modifiers": [], "additional_components": [ "DDB_G0284419", "DDB_G0267682", "Q55GG6", "DDB_G0267682", "Q54PN5", "DDB_G0284419" ] }, "reaction_10612919": { "compartment": "compartment_7660", "id": "reaction_10612919", "reactome": "R-DDI-6790454", "name": "SUMOylation of XPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611132", "species_10612903" ], "products": [ "species_10601725", "species_10612914" ], "modifiers": [ [ "species_10612916", "catalyst" ] ], "additional_components": [ "O00835", "DDB_G0278729", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "Q55CT8", "DDB_G0269906", "Q55G81", "DDB_G0267414", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296", "Q54SX2", "DDB_G0282161", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "O00835", "DDB_G0278729", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "Q55CT8", "DDB_G0269906", "Q55G81", "DDB_G0267414", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q54CS2", "DDB_G0292794", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820" ] }, "reaction_10611135": { "compartment": "compartment_7660", "id": "reaction_10611135", "reactome": "R-DDI-5690996", "name": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611128" ], "products": [ "species_113550", "species_113582", "species_10611132" ], "modifiers": [ [ "species_10611128", "catalyst" ] ], "additional_components": [ "O00835", "DDB_G0278729", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "Q55CT8", "DDB_G0269906", "Q55G81", "DDB_G0267414", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q54CS2", "DDB_G0292794", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820", "O00835", "DDB_G0278729", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "Q55CT8", "DDB_G0269906", "Q55G81", "DDB_G0267414", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296", "O00835", "DDB_G0278729", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "Q55CT8", "DDB_G0269906", "Q55G81", "DDB_G0267414", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q54CS2", "DDB_G0292794", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820" ] }, "reaction_10611950": { "compartment": "compartment_7660", "id": "reaction_10611950", "reactome": "R-DDI-5696465", "name": "USP45 deubiquitinates ERCC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10611945" ], "products": [ "species_10582633", "species_10576865" ], "modifiers": [ [ "species_10611947", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55GG6", "DDB_G0267682", "DDB_G0267682", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0274207" ] }, "reaction_10612448": { "compartment": "compartment_7660", "id": "reaction_10612448", "reactome": "R-DDI-6782208", "name": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10612443" ], "products": [ "species_10612445", "species_113541" ], "modifiers": [ [ "species_10612443", "catalyst" ] ], "additional_components": [ "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54TY2", "DDB_G0281441", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "Q54KS3", "DDB_G0287149", "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MD4", "DDB_G0286027", "Q54MH9", "DDB_G0285961", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54TY2", "DDB_G0281441", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "Q54KS3", "DDB_G0287149", "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MD4", "DDB_G0286027", "Q54MH9", "DDB_G0285961", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54TY2", "DDB_G0281441", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "Q54KS3", "DDB_G0287149", "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MD4", "DDB_G0286027", "Q54MH9", "DDB_G0285961", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677" ] }, "reaction_10612419": { "compartment": "compartment_7660", "id": "reaction_10612419", "reactome": "R-DDI-6782141", "name": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612415", "species_10582640" ], "products": [ "species_10612417" ], "modifiers": [], "additional_components": [ "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54TY2", "DDB_G0281441", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q55GG6", "DDB_G0267682", "Q54PN5", "DDB_G0284419", "Q55GG6", "DDB_G0267682", "Q54PN5", "DDB_G0284419", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54TY2", "DDB_G0281441", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10627351": { "compartment": "compartment_7660", "id": "reaction_10627351", "reactome": "R-DDI-9684118", "name": "ERCC3-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10612392" ], "products": [ "species_113550", "species_113582", "species_10612403" ], "modifiers": [ [ "species_10612392", "catalyst" ] ], "additional_components": [ "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54TY2", "DDB_G0281441", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54TY2", "DDB_G0281441", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54TY2", "DDB_G0281441", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10612424": { "compartment": "compartment_7660", "id": "reaction_10612424", "reactome": "R-DDI-6782204", "name": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612417" ], "products": [ "species_10612421" ], "modifiers": [ [ "species_10612417", "catalyst" ] ], "additional_components": [ "Q55GG6", "DDB_G0267682", "Q54PN5", "DDB_G0284419", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54TY2", "DDB_G0281441", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q869U4", "DDB_G0276443", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q55GG6", "DDB_G0267682", "Q54PN5", "DDB_G0284419", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54TY2", "DDB_G0281441", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q55GG6", "DDB_G0267682", "Q54PN5", "DDB_G0284419", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54TY2", "DDB_G0281441", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10612456": { "compartment": "compartment_7660", "id": "reaction_10612456", "reactome": "R-DDI-6782211", "name": "DNA polymerases delta, epsilon or kappa bind the TC-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577420", "species_10612452", "species_10612421", "species_10612450" ], "products": [ "species_10612454" ], "modifiers": [], "additional_components": [ "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MD4", "DDB_G0286027", "Q54MH9", "DDB_G0285961", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q869U4", "DDB_G0276443", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q55GG6", "DDB_G0267682", "Q54PN5", "DDB_G0284419", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54TY2", "DDB_G0281441", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54KS3", "DDB_G0287149", "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q869U4", "DDB_G0276443", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q55GG6", "DDB_G0267682", "Q54PN5", "DDB_G0284419", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54K47", "DDB_G0287607", "Q54KS3", "DDB_G0287149", "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MD4", "DDB_G0286027", "Q54MH9", "DDB_G0285961", "Q54TY2", "DDB_G0281441", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10612395": { "compartment": "compartment_7660", "id": "reaction_10612395", "reactome": "R-DDI-6782131", "name": "ERCC2-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10612381" ], "products": [ "species_113550", "species_113582", "species_10612392" ], "modifiers": [ [ "species_10612381", "catalyst" ] ], "additional_components": [ "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54TY2", "DDB_G0281441", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54TY2", "DDB_G0281441", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54TY2", "DDB_G0281441", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10581574": { "compartment": "compartment_7660", "id": "reaction_10581574", "reactome": "R-DDI-75172", "name": "Formation of RAD50:MRE11 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581565", "species_10581570" ], "products": [ "species_10581572" ], "modifiers": [], "additional_components": [ "DDB_G0292786", "DDB_G0293546", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786" ] }, "reaction_10611351": { "compartment": "compartment_7660", "id": "reaction_10611351", "reactome": "R-DDI-5693536", "name": "ATM phosphorylates MDC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611348" ], "products": [ "species_113582", "species_10608053" ], "modifiers": [ [ "species_10611348", "catalyst" ] ], "additional_components": [ "Q86IG6", "DDB_G0272690", "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54Z32", "DDB_G0278587", "Q54F38", "DDB_G0291185", "Q54HV7", "DDB_G0289197", "Q76NW2", "DDB_G0276863", "Q86IG6", "DDB_G0272690", "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54Z32", "DDB_G0278587", "Q54F38", "DDB_G0291185", "Q54HV7", "DDB_G0289197", "Q76NW2", "DDB_G0276863", "Q86IG6", "DDB_G0272690", "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54Z32", "DDB_G0278587", "Q54F38", "DDB_G0291185", "Q54HV7", "DDB_G0289197", "Q76NW2", "DDB_G0276863" ] }, "reaction_10611386": { "compartment": "compartment_7660", "id": "reaction_10611386", "reactome": "R-DDI-5693583", "name": "MDC1 associates with gamma-H2AFX at nuclear foci", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608042", "species_10611346" ], "products": [ "species_10611348" ], "modifiers": [], "additional_components": [ "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54Z32", "DDB_G0278587", "Q54F38", "DDB_G0291185", "Q54HV7", "DDB_G0289197", "Q76NW2", "DDB_G0276863", "Q86IG6", "DDB_G0272690", "Q86IG6", "DDB_G0272690", "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54Z32", "DDB_G0278587", "Q54F38", "DDB_G0291185", "Q54HV7", "DDB_G0289197", "Q76NW2", "DDB_G0276863" ] }, "reaction_10611356": { "compartment": "compartment_7660", "id": "reaction_10611356", "reactome": "R-DDI-5693549", "name": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611353" ], "products": [ "species_113582", "species_10608103" ], "modifiers": [ [ "species_10611353", "catalyst" ] ], "additional_components": [ "Q54Z32", "DDB_G0278587", "Q54F38", "DDB_G0291185", "Q76NW2", "DDB_G0276863", "Q54HV7", "DDB_G0289197", "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54Z32", "DDB_G0278587", "Q54F38", "DDB_G0291185", "Q54HV7", "DDB_G0289197", "Q76NW2", "DDB_G0276863", "Q54Z32", "DDB_G0278587", "Q54F38", "DDB_G0291185", "Q76NW2", "DDB_G0276863", "Q54HV7", "DDB_G0289197", "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786" ] }, "reaction_10627073": { "compartment": "compartment_70101", "id": "reaction_10627073", "reactome": "R-DDI-9656947", "name": "OGG1beta translocates to mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627069" ], "products": [ "species_10627071" ], "modifiers": [], "additional_components": [ "DDB_G0292618", "DDB_G0292618" ] }, "reaction_10580816": { "compartment": "compartment_7660", "id": "reaction_10580816", "reactome": "R-DDI-73931", "name": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580809" ], "products": [ "species_10580813" ], "modifiers": [ [ "species_10580809", "catalyst" ] ], "additional_components": [ "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713" ] }, "reaction_10582803": { "compartment": "compartment_7660", "id": "reaction_10582803", "reactome": "R-DDI-110360", "name": "Recruitment of POLB to the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582796", "species_10580793" ], "products": [ "species_10582801" ], "modifiers": [], "additional_components": [ "P51173", "DDB_G0277701", "DDB_G0284713", "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701" ] }, "reaction_10582806": { "compartment": "compartment_7660", "id": "reaction_10582806", "reactome": "R-DDI-110375", "name": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582801" ], "products": [ "species_10582782", "species_10580820", "species_30977" ], "modifiers": [ [ "species_10582801", "catalyst" ] ], "additional_components": [ "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701", "DDB_G0277701", "Q1ZXF2", "DDB_G0284713", "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701" ] }, "reaction_10580825": { "compartment": "compartment_7660", "id": "reaction_10580825", "reactome": "R-DDI-73932", "name": "Resynthesis of excised residue by POLB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10580822" ], "products": [ "species_10580809", "species_113541" ], "modifiers": [ [ "species_10580822", "catalyst" ] ], "additional_components": [ "Q1ZXF2", "DDB_G0284713", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713", "Q1ZXF2", "DDB_G0284713", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857" ] }, "reaction_10582808": { "compartment": "compartment_7660", "id": "reaction_10582808", "reactome": "R-DDI-110376", "name": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580807", "species_10580820" ], "products": [ "species_10580822" ], "modifiers": [], "additional_components": [ "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713", "Q1ZXF2", "DDB_G0284713", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857" ] }, "reaction_10582786": { "compartment": "compartment_7660", "id": "reaction_10582786", "reactome": "R-DDI-110349", "name": "Displacement of UNG glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582782", "species_10582688" ], "products": [ "species_10582682", "species_10582784" ], "modifiers": [], "additional_components": [ "DDB_G0277701", "P53766", "DDB_G0277877", "DDB_G0277877", "P51173", "DDB_G0277701" ] }, "reaction_10582788": { "compartment": "compartment_7660", "id": "reaction_10582788", "reactome": "R-DDI-110352", "name": "Displacement of NTHL1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582782", "species_10582704" ], "products": [ "species_10582675", "species_10582784" ], "modifiers": [], "additional_components": [ "DDB_G0277701", "Q86K43", "DDB_G0277247", "DDB_G0277247", "P51173", "DDB_G0277701" ] }, "reaction_10582790": { "compartment": "compartment_7660", "id": "reaction_10582790", "reactome": "R-DDI-110354", "name": "Displacement of OGG1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582782", "species_10582739" ], "products": [ "species_10582733", "species_10582784" ], "modifiers": [], "additional_components": [ "DDB_G0277701", "Q54CZ3", "DDB_G0292618", "DDB_G0292618", "P51173", "DDB_G0277701" ] }, "reaction_10582792": { "compartment": "compartment_7660", "id": "reaction_10582792", "reactome": "R-DDI-110355", "name": "Displacement of MUTYH glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582782", "species_10582760" ], "products": [ "species_10582754", "species_10582784" ], "modifiers": [], "additional_components": [ "DDB_G0277701", "Q1ZXP7", "DDB_G0270764", "DDB_G0270764", "P51173", "DDB_G0277701" ] }, "reaction_10606194": { "compartment": "compartment_7660", "id": "reaction_10606194", "reactome": "R-DDI-5649734", "name": "LIG3 ligates NEIL1,NEIL2-generated single strand break", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606186" ], "products": [ "species_10606191" ], "modifiers": [ [ "species_10606186", "catalyst" ] ], "additional_components": [ "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713" ] }, "reaction_10606184": { "compartment": "compartment_7660", "id": "reaction_10606184", "reactome": "R-DDI-5649705", "name": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10606179" ], "products": [ "species_113550", "species_10606181" ], "modifiers": [ [ "species_10606179", "catalyst" ] ], "additional_components": [ "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713" ] }, "reaction_10606189": { "compartment": "compartment_7660", "id": "reaction_10606189", "reactome": "R-DDI-5649723", "name": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10606181" ], "products": [ "species_10606186", "species_113541" ], "modifiers": [ [ "species_10606181", "catalyst" ] ], "additional_components": [ "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713" ] }, "reaction_10606225": { "compartment": "compartment_7660", "id": "reaction_10606225", "reactome": "R-DDI-5649854", "name": "Recruitment of POLB to oxidatively damaged AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582815", "species_10580793" ], "products": [ "species_10582817" ], "modifiers": [], "additional_components": [ "P51173", "DDB_G0277701", "DDB_G0284713", "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701" ] }, "reaction_10606227": { "compartment": "compartment_7660", "id": "reaction_10606227", "reactome": "R-DDI-5649856", "name": "Oxidative damage to the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582796" ], "products": [ "species_10582815" ], "modifiers": [], "additional_components": [ "P51173", "DDB_G0277701", "P51173", "DDB_G0277701" ] }, "reaction_10606288": { "compartment": "compartment_7660", "id": "reaction_10606288", "reactome": "R-DDI-5651739", "name": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606281" ], "products": [ "species_10606286", "species_10606279" ], "modifiers": [], "additional_components": [ "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820", "Q1ZXF2", "DDB_G0284713", "Q54NU0", "DDB_G0284987", "Q1ZXF2", "DDB_G0284713", "Q54NU0", "DDB_G0284987", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820" ] }, "reaction_10606304": { "compartment": "compartment_7660", "id": "reaction_10606304", "reactome": "R-DDI-5651828", "name": "PARG dePARylates PARP1,PARP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10606279" ], "products": [ "species_5651834", "species_10606233" ], "modifiers": [ [ "species_10606240", "catalyst" ] ], "additional_components": [ "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "DDB_G0277943" ] }, "reaction_10606242": { "compartment": "compartment_7660", "id": "reaction_10606242", "reactome": "R-DDI-5649873", "name": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577480", "species_10606233", "species_10582821" ], "products": [ "species_10582782", "species_10606235" ], "modifiers": [ [ "species_10606240", "catalyst" ] ], "additional_components": [ "DDB_G0284987", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701", "DDB_G0277701", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q1ZXF2", "DDB_G0284713", "Q54NU0", "DDB_G0284987", "DDB_G0277943" ] }, "reaction_10606296": { "compartment": "compartment_7660", "id": "reaction_10606296", "reactome": "R-DDI-5651773", "name": "LIG1 binds POLB at long-patch BER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606292", "species_10577488" ], "products": [ "species_10606294" ], "modifiers": [], "additional_components": [ "Q1ZXF2", "DDB_G0284713", "DDB_G0274493", "Q869E1", "DDB_G0274493", "Q1ZXF2", "DDB_G0284713" ] }, "reaction_10606250": { "compartment": "compartment_7660", "id": "reaction_10606250", "reactome": "R-DDI-5649883", "name": "POLB-mediated DNA strand displacement synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10606235" ], "products": [ "species_10606247", "species_113541" ], "modifiers": [ [ "species_10606235", "catalyst" ] ], "additional_components": [ "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q1ZXF2", "DDB_G0284713", "Q54NU0", "DDB_G0284987", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q1ZXF2", "DDB_G0284713", "Q54NU0", "DDB_G0284987", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q1ZXF2", "DDB_G0284713", "Q54NU0", "DDB_G0284987" ] }, "reaction_10606301": { "compartment": "compartment_7660", "id": "reaction_10606301", "reactome": "R-DDI-5651789", "name": "LIG1 bound to POLB ligates SSB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606294" ], "products": [ "species_10606298" ], "modifiers": [ [ "species_10606294", "catalyst" ] ], "additional_components": [ "Q869E1", "DDB_G0274493", "Q1ZXF2", "DDB_G0284713", "Q869E1", "DDB_G0274493", "Q1ZXF2", "DDB_G0284713", "Q869E1", "DDB_G0274493", "Q1ZXF2", "DDB_G0284713" ] }, "reaction_10606284": { "compartment": "compartment_7660", "id": "reaction_10606284", "reactome": "R-DDI-5651723", "name": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606247", "species_427523" ], "products": [ "species_427497", "species_10606281" ], "modifiers": [ [ "species_10606247", "catalyst" ] ], "additional_components": [ "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q1ZXF2", "DDB_G0284713", "Q54NU0", "DDB_G0284987", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820", "Q1ZXF2", "DDB_G0284713", "Q54NU0", "DDB_G0284987", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q1ZXF2", "DDB_G0284713", "Q54NU0", "DDB_G0284987" ] }, "reaction_10582824": { "compartment": "compartment_7660", "id": "reaction_10582824", "reactome": "R-DDI-111253", "name": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10582817" ], "products": [ "species_10582821", "species_113541" ], "modifiers": [ [ "species_10582817", "catalyst" ] ], "additional_components": [ "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701", "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701", "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701" ] }, "reaction_10582799": { "compartment": "compartment_7660", "id": "reaction_10582799", "reactome": "R-DDI-110359", "name": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582784" ], "products": [ "species_10582796" ], "modifiers": [ [ "species_10582784", "catalyst" ] ], "additional_components": [ "P51173", "DDB_G0277701", "P51173", "DDB_G0277701", "P51173", "DDB_G0277701" ] }, "reaction_10626280": { "compartment": "compartment_876", "id": "reaction_10626280", "reactome": "R-DDI-9634834", "name": "ACHEIs bind ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9634838", "species_10589588" ], "products": [ "species_10589591" ], "modifiers": [], "additional_components": [ "Q54ET7", "DDB_G0291344", "Q86L18", "DDB_G0291344", "P18142", "DDB_G0283085", "Q54N21", "DDB_G0291344", "Q54WD8", "DDB_G0291344", "P21837", "DDB_G0285419", "Q54ET7", "DDB_G0291344", "Q86L18", "DDB_G0291344", "P18142", "DDB_G0283085", "Q54N21", "DDB_G0291344", "Q54WD8", "DDB_G0291344", "P21837", "DDB_G0285419" ] }, "reaction_10588771": { "compartment": "compartment_70101", "id": "reaction_10588771", "reactome": "R-DDI-210444", "name": "L-Glutamate loading of synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_10588768" ], "products": [ "species_10588746" ], "modifiers": [ [ "species_10588768", "catalyst" ] ], "additional_components": [ "Q54W37", "DDB_G0280761", "Q54UX4", "DDB_G0280761", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q1ZXE7", "DDB_G0286169", "P20790", "DDB_G0280043", "Q54RY4", "DDB_G0282899", "P20791", "DDB_G0276399", "Q54W37", "DDB_G0280761", "Q54UX4", "DDB_G0280761", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q1ZXE7", "DDB_G0286169", "P20790", "DDB_G0280043", "Q54RY4", "DDB_G0282899", "P20791", "DDB_G0276399", "species_113552", "Q54W37", "DDB_G0280761", "Q54UX4", "DDB_G0280761", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q1ZXE7", "DDB_G0286169", "P20790", "DDB_G0280043", "Q54RY4", "DDB_G0282899", "P20791", "DDB_G0276399" ] }, "reaction_10594460": { "compartment": "compartment_5460", "id": "reaction_10594460", "reactome": "R-DDI-916855", "name": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_916850", "species_113594" ], "products": [ "species_880046", "species_113552" ], "modifiers": [ [ "species_10594457", "catalyst" ] ], "additional_components": [ "Q55FI1", "DDB_G0268104", "CHEBI:33739" ] }, "reaction_10589611": { "compartment": "compartment_70101", "id": "reaction_10589611", "reactome": "R-DDI-374909", "name": "Metabolism of Noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209789", "species_29356", "species_29368" ], "products": [ "species_5279533", "species_29382", "species_29408" ], "modifiers": [ [ "species_10583604", "catalyst" ] ], "additional_components": [ "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10625621": { "compartment": "compartment_7660", "id": "reaction_10625621", "reactome": "R-DDI-9029434", "name": "p-S363,S380,T573 RS6K translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625593" ], "products": [ "species_10625619" ], "modifiers": [], "additional_components": [ "P34102", "DDB_G0286125", "Q8MYF1", "DDB_G0277449", "Q8MYF1", "DDB_G0277449", "P34102", "DDB_G0286125" ] }, "reaction_10613600": { "compartment": "compartment_876", "id": "reaction_10613600", "reactome": "R-DDI-6797630", "name": "LRPP4(LRPP1-3,5) hydrolyse LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_417891" ], "products": [ "species_109277", "species_6797635" ], "modifiers": [ [ "species_10613597", "catalyst" ] ], "additional_components": [ "Q54PR7", "DDB_G0284367", "Q86AF0", "DDB_G0284367", "Q8MXL9", "DDB_G0284367" ] }, "reaction_10590801": { "compartment": "compartment_70101", "id": "reaction_10590801", "reactome": "R-DDI-418553", "name": "cAMP degradation by Phosphodiesterases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10590798", "catalyst" ] ], "additional_components": [ "B0G0Y8", "DDB_G0268634", "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121" ] }, "reaction_10627473": { "compartment": "compartment_70101", "id": "reaction_10627473", "reactome": "R-DDI-9708261", "name": "PDE4A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10583084", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121" ] }, "reaction_10626265": { "compartment": "compartment_70101", "id": "reaction_10626265", "reactome": "R-DDI-9629675", "name": "PDE3A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10626262", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121" ] }, "reaction_10627406": { "compartment": "compartment_70101", "id": "reaction_10627406", "reactome": "R-DDI-9705507", "name": "PDE3B hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10627403", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121" ] }, "reaction_10590562": { "compartment": "compartment_876", "id": "reaction_10590562", "reactome": "R-DDI-392064", "name": "G alpha (z) inhibits adenylate cyclase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590558", "species_10583022" ], "products": [ "species_10590560" ], "modifiers": [], "additional_components": [ "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545" ] }, "reaction_10624233": { "compartment": "compartment_876", "id": "reaction_10624233", "reactome": "R-DDI-8981892", "name": "Active G alpha (z) binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590558", "species_10624229" ], "products": [ "species_10624231" ], "modifiers": [], "additional_components": [ "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "Q55E55", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q55E55", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q54M81", "DDB_G0286817", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438" ] }, "reaction_10624313": { "compartment": "compartment_876", "id": "reaction_10624313", "reactome": "R-DDI-8982021", "name": "G alpha (z) in G alpha (z):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624231" ], "products": [ "species_10624301", "species_29372" ], "modifiers": [ [ "species_10624231", "catalyst" ] ], "additional_components": [ "Q55E55", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q54M81", "DDB_G0286817", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "Q55E55", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q54M81", "DDB_G0286817", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29420", "Q55E55", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q54M81", "DDB_G0286817", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438" ] }, "reaction_10624303": { "compartment": "compartment_876", "id": "reaction_10624303", "reactome": "R-DDI-8982018", "name": "G alpha (z):RGS complex dissociates to give inactive G alpha (z)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624301" ], "products": [ "species_10624229", "species_10594134" ], "modifiers": [], "additional_components": [ "Q55E55", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q54M81", "DDB_G0286817", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29420", "Q55E55", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q54M81", "DDB_G0286817", "species_29420", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343" ] }, "reaction_10590810": { "compartment": "compartment_876", "id": "reaction_10590810", "reactome": "R-DDI-418574", "name": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590657" ], "products": [ "species_10590807" ], "modifiers": [ [ "species_10590657", "catalyst" ] ], "additional_components": [ "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29420", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438" ] }, "reaction_10625832": { "compartment": "compartment_70101", "id": "reaction_10625832", "reactome": "R-DDI-9603279", "name": "PIP3 recruits PDK1 and AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10587607", "species_10590487" ], "products": [ "species_10625830" ], "modifiers": [], "additional_components": [ "DDB_G0281471", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "Q54TW2", "DDB_G0281471", "species_179838", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795" ] }, "reaction_10590605": { "compartment": "compartment_70101", "id": "reaction_10590605", "reactome": "R-DDI-392300", "name": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10590602", "catalyst" ] ], "additional_components": [ "Q54DK0", "DDB_G0292252", "P54675", "DDB_G0275011", "P54673", "DDB_G0278727", "Q54S78", "DDB_G0282625", "Q55FX5", "DDB_G0282625", "P54674", "DDB_G0283081", "P36408", "DDB_G0277143" ] }, "reaction_10602042": { "compartment": "compartment_70101", "id": "reaction_10602042", "reactome": "R-DDI-3134962", "name": "DHX36 binds DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602038", "species_3134861" ], "products": [ "species_10602040" ], "modifiers": [], "additional_components": [ "DDB_G0275313", "Q869Z1", "DDB_G0275313" ] }, "reaction_10602073": { "compartment": "compartment_70101", "id": "reaction_10602073", "reactome": "R-DDI-3204303", "name": "MRE11 binds cytosolic DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_874088", "species_10602069" ], "products": [ "species_10602071" ], "modifiers": [], "additional_components": [ "DDB_G0293546", "Q54BN2", "DDB_G0293546", "species_874088" ] }, "reaction_10624938": { "compartment": "compartment_70101", "id": "reaction_10624938", "reactome": "R-DDI-9013869", "name": "DDX41 binds bacterial c-di-AMP, c-di-GMP ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8982080", "species_10602033" ], "products": [ "species_10624936" ], "modifiers": [], "additional_components": [ "CHEBI:49537", "CHEBI:47037", "DDB_G0287361", "Q54KG1", "DDB_G0287361", "CHEBI:49537", "CHEBI:47037" ] }, "reaction_10605089": { "compartment": "compartment_263163", "id": "reaction_10605089", "reactome": "R-DDI-5333658", "name": "CLAT:AP1:CLVS bind PI(3,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5334668", "species_10605085" ], "products": [ "species_10605087" ], "modifiers": [], "additional_components": [ "P25870", "DDB_G0277221", "Q54X82", "DDB_G0279141", "Q8I8U2", "DDB_G0281957", "Q54HS9", "DDB_G0289247", "Q54WW3", "DDB_G0279359", "B0G185", "DDB_G0295711", "P25870", "DDB_G0277221", "Q54X82", "DDB_G0279141", "Q8I8U2", "DDB_G0281957", "Q54HS9", "DDB_G0289247", "Q54WW3", "DDB_G0279359", "B0G185", "DDB_G0295711", "species_1806205" ] }, "reaction_10604872": { "compartment": "compartment_171907", "id": "reaction_10604872", "reactome": "R-DDI-5229111", "name": "AP4 transports APP from trans-Golgi network to endosome lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604855" ], "products": [ "species_10604869" ], "modifiers": [ [ "species_10604855", "catalyst" ] ], "additional_components": [ "Q54VE0", "DDB_G0280427", "Q9GPF0", "DDB_G0276945", "Q54NZ4", "DDB_G0284905", "Q54R84", "DDB_G0283319", "Q9GPF0", "DDB_G0276945", "Q54NZ4", "DDB_G0284905", "Q54R84", "DDB_G0283319", "Q54VE0", "DDB_G0280427", "Q54VE0", "DDB_G0280427", "Q9GPF0", "DDB_G0276945", "Q54NZ4", "DDB_G0284905", "Q54R84", "DDB_G0283319" ] }, "reaction_10592299": { "compartment": "compartment_70101", "id": "reaction_10592299", "reactome": "R-DDI-432706", "name": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10591135", "species_10591129", "species_10591141", "species_10592293" ], "products": [ "species_10589294", "species_29372", "species_10592297" ], "modifiers": [], "additional_components": [ "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "O00909", "DDB_G0289173", "Q54Y34", "DDB_G0292332", "Q1ZXA5", "DDB_G0292332", "Q54YV7", "DDB_G0278057", "Q54HK2", "DDB_G0289435", "Q55AR1", "DDB_G0271792", "Q54JJ3", "DDB_G0288015", "Q54SH9", "DDB_G0282457", "Q54V41", "DDB_G0280633", "Q54V47", "DDB_G0280621", "Q54VB0", "DDB_G0280479", "species_29438", "Q54HS9", "DDB_G0289247", "Q54WW3", "DDB_G0279359", "B0G185", "DDB_G0295711", "Q8I8U2", "DDB_G0281957", "Q54X82", "DDB_G0279141", "species_29420", "Q54V41", "DDB_G0280633", "Q54Y34", "DDB_G0292332", "Q54HK2", "DDB_G0289435", "Q54YV7", "DDB_G0278057", "Q54JJ3", "DDB_G0288015", "Q54V47", "DDB_G0280621", "O00909", "DDB_G0289173", "Q54VB0", "DDB_G0280479", "Q55AR1", "DDB_G0271792", "Q1ZXA5", "DDB_G0292332", "Q54SH9", "DDB_G0282457", "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "Q54HS9", "DDB_G0289247", "Q54WW3", "DDB_G0279359", "B0G185", "DDB_G0295711", "Q8I8U2", "DDB_G0281957", "Q54X82", "DDB_G0279141", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131" ] }, "reaction_10592302": { "compartment": "compartment_70101", "id": "reaction_10592302", "reactome": "R-DDI-432707", "name": "trans-Golgi Network Lysosomal Vesicle Scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10592297" ], "products": [ "species_10591135", "species_29372", "species_29420", "species_10591141", "species_10592225" ], "modifiers": [ [ "species_10592297", "catalyst" ] ], "additional_components": [ "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "Q54HS9", "DDB_G0289247", "Q54WW3", "DDB_G0279359", "B0G185", "DDB_G0295711", "Q8I8U2", "DDB_G0281957", "Q54X82", "DDB_G0279141", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "Q54X82", "DDB_G0279141", "Q8I8U2", "DDB_G0281957", "Q54HS9", "DDB_G0289247", "B0G185", "DDB_G0295711", "Q54WW3", "DDB_G0279359", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "Q54HS9", "DDB_G0289247", "Q54WW3", "DDB_G0279359", "B0G185", "DDB_G0295711", "Q8I8U2", "DDB_G0281957", "Q54X82", "DDB_G0279141", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131" ] }, "reaction_10589739": { "compartment": "compartment_70101", "id": "reaction_10589739", "reactome": "R-DDI-376357", "name": "Vamp7 associated Lysosome to Plasma membrane transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589710", "species_10589716", "species_10589728" ], "products": [ "species_10589710", "species_10589734", "species_10589716" ], "modifiers": [ [ "species_10589736", "catalyst" ] ], "additional_components": [ "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556", "Q54NW7", "DDB_G0284951", "Q86AQ7", "DDB_G0277173", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54NW7", "DDB_G0284951", "Q86AQ7", "DDB_G0277173", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556", "Q54NW7", "DDB_G0284951", "Q86AQ7", "DDB_G0277173", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590" ] }, "reaction_10589773": { "compartment": "compartment_876", "id": "reaction_10589773", "reactome": "R-DDI-376369", "name": "Vamp2 associated secretory vesicle to plasma membrane transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589710", "species_10589716", "species_10589762" ], "products": [ "species_10589710", "species_10589768", "species_10589716" ], "modifiers": [ [ "species_10589770", "catalyst" ] ], "additional_components": [ "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590" ] }, "reaction_10589340": { "compartment": "compartment_70101", "id": "reaction_10589340", "reactome": "R-DDI-350769", "name": "trans-Golgi Network Coat Activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589294", "species_29438" ], "products": [ "species_29420", "species_10589320" ], "modifiers": [ [ "species_10589337", "catalyst" ] ], "additional_components": [ "species_29420", "Q54V41", "DDB_G0280633", "Q54Y34", "DDB_G0292332", "Q54HK2", "DDB_G0289435", "Q54YV7", "DDB_G0278057", "Q54JJ3", "DDB_G0288015", "Q54V47", "DDB_G0280621", "O00909", "DDB_G0289173", "Q54VB0", "DDB_G0280479", "Q55AR1", "DDB_G0271792", "Q1ZXA5", "DDB_G0292332", "Q54SH9", "DDB_G0282457", "O00909", "DDB_G0289173", "Q54Y34", "DDB_G0292332", "Q1ZXA5", "DDB_G0292332", "Q54YV7", "DDB_G0278057", "Q54HK2", "DDB_G0289435", "Q55AR1", "DDB_G0271792", "Q54JJ3", "DDB_G0288015", "Q54SH9", "DDB_G0282457", "Q54V41", "DDB_G0280633", "Q54V47", "DDB_G0280621", "Q54VB0", "DDB_G0280479", "species_29438", "Q54X30", "DDB_G0290771", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771" ] }, "reaction_10589756": { "compartment": "compartment_70101", "id": "reaction_10589756", "reactome": "R-DDI-376364", "name": "Vamp8 associated secretory vesicle to plasma membrane transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589710", "species_10589716", "species_10589745" ], "products": [ "species_10589710", "species_10589751", "species_10589716" ], "modifiers": [ [ "species_10589753", "catalyst" ] ], "additional_components": [ "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590" ] }, "reaction_10586000": { "compartment": "compartment_984", "id": "reaction_10586000", "reactome": "R-DDI-189102", "name": "maltose + H2O => 2 D-glucose (maltase-glucoamylase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_188986" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10585997", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10586372": { "compartment": "compartment_984", "id": "reaction_10586372", "reactome": "R-DDI-191101", "name": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_191103" ], "products": [ "species_188986", "species_70115" ], "modifiers": [ [ "species_10585987", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10585990": { "compartment": "compartment_984", "id": "reaction_10585990", "reactome": "R-DDI-189053", "name": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_189108" ], "products": [ "species_191103", "species_188986", "species_70115" ], "modifiers": [ [ "species_10585987", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10586374": { "compartment": "compartment_984", "id": "reaction_10586374", "reactome": "R-DDI-191108", "name": "maltose + H2O => 2 D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_188986" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10585987", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10585993": { "compartment": "compartment_984", "id": "reaction_10585993", "reactome": "R-DDI-189069", "name": "sucrose + H2O => glucose + fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_188980" ], "products": [ "species_189049", "species_70115" ], "modifiers": [ [ "species_10585987", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10586376": { "compartment": "compartment_984", "id": "reaction_10586376", "reactome": "R-DDI-191116", "name": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_191103" ], "products": [ "species_188986", "species_70115" ], "modifiers": [ [ "species_10585997", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10606570": { "compartment": "compartment_984", "id": "reaction_10606570", "reactome": "R-DDI-5659861", "name": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_5659875" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10585987", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10623860": { "compartment": "compartment_7660", "id": "reaction_10623860", "reactome": "R-DDI-8953398", "name": "PIR oxygenates quercetin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8953397", "species_113685" ], "products": [ "species_8953399", "species_8953383" ], "modifiers": [ [ "species_10623857", "catalyst" ] ], "additional_components": [ "DDB_G0273413" ] }, "reaction_10600033": { "compartment": "compartment_876", "id": "reaction_10600033", "reactome": "R-DDI-2029471", "name": "Hydrolysis of PC to PA by PLD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429802", "species_29356" ], "products": [ "species_264618", "species_1602448" ], "modifiers": [ [ "species_10600030", "catalyst" ] ], "additional_components": [ "Q54Z25", "DDB_G0277949" ] }, "reaction_10600008": { "compartment": "compartment_876", "id": "reaction_10600008", "reactome": "R-DDI-2029468", "name": "Conversion of PA into DAG by PAP-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1602448" ], "products": [ "species_29372", "species_112275" ], "modifiers": [ [ "species_10600005", "catalyst" ] ], "additional_components": [ "Q54PR7", "DDB_G0284367", "Q86AF0", "DDB_G0284367", "Q8MXL9", "DDB_G0284367" ] }, "reaction_10620323": { "compartment": "compartment_876", "id": "reaction_10620323", "reactome": "R-DDI-8868648", "name": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10620318" ], "products": [ "species_29372", "species_10620320" ], "modifiers": [ [ "species_10620318", "catalyst" ] ], "additional_components": [ "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "species_179856", "Q54U74", "DDB_G0281235", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q555L8", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q75JD4", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "B0G198", "DDB_G0295683", "Q1ZXE9", "DDB_G0285703", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29438", "Q54U74", "DDB_G0281235", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q54KI4", "DDB_G0287325", "species_1806180", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "species_113592", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q1ZXE9", "DDB_G0285703", "B0G198", "DDB_G0295683", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q55AN3", "DDB_G0274805", "Q555L8", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "C7FZZ0", "DDB_G0274805", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29438", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "species_179856", "Q54U74", "DDB_G0281235", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q555L8", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q75JD4", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "B0G198", "DDB_G0295683", "Q1ZXE9", "DDB_G0285703", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29438" ] }, "reaction_10619620": { "compartment": "compartment_876", "id": "reaction_10619620", "reactome": "R-DDI-8856808", "name": "Recruitment of AP-2 complex and clathrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10591129", "species_10619610", "species_10619527", "species_10619616", "species_10619539" ], "products": [ "species_10619618" ], "modifiers": [], "additional_components": [ "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q54KI4", "DDB_G0287325", "species_179856", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54U74", "DDB_G0281235", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q54U74", "DDB_G0281235", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q54KI4", "DDB_G0287325", "species_179856" ] }, "reaction_10620325": { "compartment": "compartment_876", "id": "reaction_10620325", "reactome": "R-DDI-8868651", "name": "Endophilins recruit synaptojanins to the clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620314", "species_10598818" ], "products": [ "species_10620318" ], "modifiers": [], "additional_components": [ "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "species_179856", "Q54U74", "DDB_G0281235", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q555L8", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q75JD4", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "B0G198", "DDB_G0295683", "Q1ZXE9", "DDB_G0285703", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29438", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "species_179856", "Q54U74", "DDB_G0281235", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q555L8", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q75JD4", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "B0G198", "DDB_G0295683", "Q1ZXE9", "DDB_G0285703", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29438" ] }, "reaction_10620267": { "compartment": "compartment_876", "id": "reaction_10620267", "reactome": "R-DDI-8868066", "name": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10598590", "catalyst" ] ], "additional_components": [ "Q54DL4", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635", "Q86D86", "DDB_G0283615" ] }, "reaction_10619662": { "compartment": "compartment_876", "id": "reaction_10619662", "reactome": "R-DDI-8862280", "name": "FCHo proteins bind nascent clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619596", "species_10619608", "species_10588585", "species_10619588", "species_10619590", "species_10619586" ], "products": [ "species_10619610" ], "modifiers": [], "additional_components": [ "species_179856", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q555L8", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q75JD4", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "DDB_G0287325", "DDB_G0287325", "DDB_G0287325", "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q54KI4", "DDB_G0287325", "species_179856", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403" ] }, "reaction_10619630": { "compartment": "compartment_876", "id": "reaction_10619630", "reactome": "R-DDI-8856813", "name": "AAK1 phosphorylates AP-2 mu subunit at T156", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10619618" ], "products": [ "species_29370", "species_10619627" ], "modifiers": [ [ "species_10619618", "catalyst" ] ], "additional_components": [ "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q54U74", "DDB_G0281235", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q54KI4", "DDB_G0287325", "species_179856", "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q54U74", "DDB_G0281235", "species_179856", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q54U74", "DDB_G0281235", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q54KI4", "DDB_G0287325", "species_179856" ] }, "reaction_10621967": { "compartment": "compartment_24339", "id": "reaction_10621967", "reactome": "R-DDI-8871194", "name": "RAB5 and GAPVD1 bind AP-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10621961", "species_10620427" ], "products": [ "species_10621963" ], "modifiers": [], "additional_components": [ "Q86JP3", "DDB_G0271984", "species_29420", "Q54HF9", "DDB_G0291115", "Q54W41", "DDB_G0291115", "Q55AA6", "DDB_G0291115", "Q54NU1", "DDB_G0291115", "Q55AI4", "DDB_G0291115", "Q54VS5", "DDB_G0291115", "Q54F48", "DDB_G0291115", "Q54U74", "DDB_G0281235", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q54KI4", "DDB_G0287325", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29420", "Q54UC8", "DDB_G0281155", "Q55FQ9", "DDB_G0267440", "Q54P67", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54JR2", "DDB_G0287691", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54Y50", "DDB_G0278685", "species_1806180", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q8T867", "DDB_G0276447", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "species_113592", "Q1ZXE9", "DDB_G0285703", "B0G198", "DDB_G0295683", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q55AN3", "DDB_G0274805", "Q555L8", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "C7FZZ0", "DDB_G0274805", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q54U74", "DDB_G0281235", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q54KI4", "DDB_G0287325", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29420", "Q54UC8", "DDB_G0281155", "Q55FQ9", "DDB_G0267440", "Q54P67", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54JR2", "DDB_G0287691", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54Y50", "DDB_G0278685", "species_1806180", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q8T867", "DDB_G0276447", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "species_113592", "Q1ZXE9", "DDB_G0285703", "B0G198", "DDB_G0295683", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q55AN3", "DDB_G0274805", "Q555L8", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "C7FZZ0", "DDB_G0274805", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q86JP3", "DDB_G0271984", "Q54HF9", "DDB_G0291115", "Q54W41", "DDB_G0291115", "Q55AA6", "DDB_G0291115", "Q54NU1", "DDB_G0291115", "Q55AI4", "DDB_G0291115", "Q54VS5", "DDB_G0291115", "Q54F48", "DDB_G0291115" ] }, "reaction_10619890": { "compartment": "compartment_70101", "id": "reaction_10619890", "reactome": "R-DDI-8866275", "name": "UBQLNs bind UIM-containing adaptor proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619886", "species_10619878" ], "products": [ "species_10619888" ], "modifiers": [], "additional_components": [ "Q54KI4", "DDB_G0287325", "Q54EH1", "DDB_G0291512", "DDB_G0267452", "Q9NIF3", "DDB_G0267452", "Q54KI4", "DDB_G0287325", "Q54EH1", "DDB_G0291512" ] }, "reaction_10619715": { "compartment": "compartment_70101", "id": "reaction_10619715", "reactome": "R-DDI-8863723", "name": "COP9 and TOR1 deneddylate STON2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619706" ], "products": [ "species_10619710", "species_10619704", "species_10611062", "species_10619684" ], "modifiers": [ [ "species_10619706", "catalyst" ] ], "additional_components": [ "Q55FE2", "DDB_G0268156", "Q75K24", "DDB_G0275471", "Q54C92", "DDB_G0293180", "Q54QX3", "DDB_G0283587", "Q55BD5", "DDB_G0271282", "Q54E53", "DDB_G0291848", "Q54HL6", "DDB_G0289361", "Q54PF3", "DDB_G0284597", "Q54B82", "DDB_G0293844", "P54672", "DDB_G0277139", "DDB_G0277139", "Q75K24", "DDB_G0275471", "Q54C92", "DDB_G0293180", "Q54QX3", "DDB_G0283587", "Q55BD5", "DDB_G0271282", "Q54E53", "DDB_G0291848", "Q54HL6", "DDB_G0289361", "Q54PF3", "DDB_G0284597", "Q54B82", "DDB_G0293844", "DDB_G0278711", "Q55FE2", "DDB_G0268156", "Q55FE2", "DDB_G0268156", "Q75K24", "DDB_G0275471", "Q54C92", "DDB_G0293180", "Q54QX3", "DDB_G0283587", "Q55BD5", "DDB_G0271282", "Q54E53", "DDB_G0291848", "Q54HL6", "DDB_G0289361", "Q54PF3", "DDB_G0284597", "Q54B82", "DDB_G0293844", "P54672", "DDB_G0277139" ] }, "reaction_10627348": { "compartment": "compartment_70101", "id": "reaction_10627348", "reactome": "R-DDI-9681616", "name": "AP2 binds chlorpromazine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9648300", "species_10619527" ], "products": [ "species_10619943" ], "modifiers": [], "additional_components": [ "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439" ] }, "reaction_10619717": { "compartment": "compartment_70101", "id": "reaction_10619717", "reactome": "R-DDI-8863727", "name": "STON2 is neddylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619710", "species_10611062" ], "products": [ "species_10619672" ], "modifiers": [], "additional_components": [ "DDB_G0277139", "DDB_G0278711", "DDB_G0277139" ] }, "reaction_10619945": { "compartment": "compartment_876", "id": "reaction_10619945", "reactome": "R-DDI-8866277", "name": "AP-2 directly binds some endocytic cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619527", "species_10619939" ], "products": [ "species_10619941" ], "modifiers": [ [ "species_10619943", "inhibitor" ] ], "additional_components": [ "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439" ] }, "reaction_10620089": { "compartment": "compartment_876", "id": "reaction_10620089", "reactome": "R-DDI-8867613", "name": "PICALM binds R-SNAREs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620079", "species_10620085" ], "products": [ "species_10620087" ], "modifiers": [], "additional_components": [ "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54Y50", "DDB_G0278685", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061" ] }, "reaction_10619708": { "compartment": "compartment_70101", "id": "reaction_10619708", "reactome": "R-DDI-8863721", "name": "NEDD8-STON binds TOR1 hexamer and COP9 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619704", "species_10619672", "species_10619684" ], "products": [ "species_10619706" ], "modifiers": [], "additional_components": [ "Q75K24", "DDB_G0275471", "Q54C92", "DDB_G0293180", "Q54QX3", "DDB_G0283587", "Q55BD5", "DDB_G0271282", "Q54E53", "DDB_G0291848", "Q54HL6", "DDB_G0289361", "Q54PF3", "DDB_G0284597", "Q54B82", "DDB_G0293844", "DDB_G0277139", "Q55FE2", "DDB_G0268156", "Q55FE2", "DDB_G0268156", "Q75K24", "DDB_G0275471", "Q54C92", "DDB_G0293180", "Q54QX3", "DDB_G0283587", "Q55BD5", "DDB_G0271282", "Q54E53", "DDB_G0291848", "Q54HL6", "DDB_G0289361", "Q54PF3", "DDB_G0284597", "Q54B82", "DDB_G0293844", "P54672", "DDB_G0277139" ] }, "reaction_10620237": { "compartment": "compartment_876", "id": "reaction_10620237", "reactome": "R-DDI-8867756", "name": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620157", "species_10619627" ], "products": [ "species_10620159" ], "modifiers": [], "additional_components": [ "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q54U74", "DDB_G0281235", "species_179856", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q54U74", "DDB_G0281235", "species_179856", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691" ] }, "reaction_10620269": { "compartment": "compartment_876", "id": "reaction_10620269", "reactome": "R-DDI-8868071", "name": "Clathrin recruits PIK3C2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620159", "species_10598852" ], "products": [ "species_10620161" ], "modifiers": [], "additional_components": [ "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q54U74", "DDB_G0281235", "species_179856", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q54S78", "DDB_G0282625", "Q55FX5", "DDB_G0282625", "P54673", "DDB_G0278727", "P54674", "DDB_G0283081", "P54675", "DDB_G0275011", "Q54S78", "DDB_G0282625", "Q55FX5", "DDB_G0282625", "P54673", "DDB_G0278727", "P54674", "DDB_G0283081", "P54675", "DDB_G0275011", "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q54U74", "DDB_G0281235", "species_179856", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691" ] }, "reaction_10621965": { "compartment": "compartment_24339", "id": "reaction_10621965", "reactome": "R-DDI-8871193", "name": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10621963" ], "products": [ "species_10620531", "species_10619539" ], "modifiers": [], "additional_components": [ "Q54U74", "DDB_G0281235", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q54KI4", "DDB_G0287325", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29420", "Q54UC8", "DDB_G0281155", "Q55FQ9", "DDB_G0267440", "Q54P67", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54JR2", "DDB_G0287691", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54Y50", "DDB_G0278685", "species_1806180", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q8T867", "DDB_G0276447", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "species_113592", "Q1ZXE9", "DDB_G0285703", "B0G198", "DDB_G0295683", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q55AN3", "DDB_G0274805", "Q555L8", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "C7FZZ0", "DDB_G0274805", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q86JP3", "DDB_G0271984", "Q54HF9", "DDB_G0291115", "Q54W41", "DDB_G0291115", "Q55AA6", "DDB_G0291115", "Q54NU1", "DDB_G0291115", "Q55AI4", "DDB_G0291115", "Q54VS5", "DDB_G0291115", "Q54F48", "DDB_G0291115", "Q54U74", "DDB_G0281235", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q54KI4", "DDB_G0287325", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29420", "Q54UC8", "DDB_G0281155", "Q55FQ9", "DDB_G0267440", "Q54P67", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54JR2", "DDB_G0287691", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54Y50", "DDB_G0278685", "species_1806180", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q8T867", "DDB_G0276447", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "species_113592", "Q1ZXE9", "DDB_G0285703", "B0G198", "DDB_G0295683", "Q55AN3", "DDB_G0274805", "Q555L8", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "C7FZZ0", "DDB_G0274805", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q86JP3", "DDB_G0271984", "species_29438", "Q54HF9", "DDB_G0291115", "Q54W41", "DDB_G0291115", "Q55AA6", "DDB_G0291115", "Q54NU1", "DDB_G0291115", "Q55AI4", "DDB_G0291115", "Q54VS5", "DDB_G0291115", "Q54F48", "DDB_G0291115", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111" ] }, "reaction_10620272": { "compartment": "compartment_876", "id": "reaction_10620272", "reactome": "R-DDI-8868072", "name": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10620161", "catalyst" ] ], "additional_components": [ "Q54S78", "DDB_G0282625", "Q55FX5", "DDB_G0282625", "P54673", "DDB_G0278727", "P54674", "DDB_G0283081", "P54675", "DDB_G0275011", "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q54U74", "DDB_G0281235", "species_179856", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691" ] }, "reaction_10620432": { "compartment": "compartment_24339", "id": "reaction_10620432", "reactome": "R-DDI-8868658", "name": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10620425" ], "products": [ "species_10620429", "species_29372", "species_10620427" ], "modifiers": [ [ "species_10620425", "catalyst" ] ], "additional_components": [ "Q54U74", "DDB_G0281235", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29420", "Q54KI4", "DDB_G0287325", "Q8T867", "DDB_G0276447", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "species_113592", "P36415", "DDB_G0269144", "Q55AN3", "DDB_G0274805", "Q555L8", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "C7FZZ0", "DDB_G0274805", "Q54UC8", "DDB_G0281155", "Q55FQ9", "DDB_G0267440", "Q54P67", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q54D31", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10591129", "species_10619527", "species_179856" ], "products": [ "species_10619596" ], "modifiers": [], "additional_components": [ "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "species_179856", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403" ] }, "reaction_10620438": { "compartment": "compartment_24339", "id": "reaction_10620438", "reactome": "R-DDI-8868659", "name": "Clathrin recruits auxilins to the clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"reaction_10620440": { "compartment": "compartment_24339", "id": "reaction_10620440", "reactome": "R-DDI-8868660", "name": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602861", "species_10620436" ], "products": [ "species_10620425" ], "modifiers": [], "additional_components": [ "species_113592", "P36415", "DDB_G0269144", "Q54U74", "DDB_G0281235", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29420", "Q54KI4", "DDB_G0287325", "Q8T867", "DDB_G0276447", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q55AN3", "DDB_G0274805", "Q555L8", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "C7FZZ0", "DDB_G0274805", "Q54UC8", "DDB_G0281155", "Q55FQ9", "DDB_G0267440", "Q54P67", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54JR2", "DDB_G0287691", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54Y50", "DDB_G0278685", "species_1806180", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "species_113592", "Q1ZXE9", "DDB_G0285703", "B0G198", "DDB_G0295683", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54U74", "DDB_G0281235", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29420", "Q54KI4", "DDB_G0287325", "Q8T867", "DDB_G0276447", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "species_113592", "P36415", "DDB_G0269144", "Q55AN3", "DDB_G0274805", "Q555L8", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "C7FZZ0", "DDB_G0274805", "Q54UC8", "DDB_G0281155", "Q55FQ9", "DDB_G0267440", "Q54P67", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54JR2", "DDB_G0287691", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54Y50", "DDB_G0278685", "species_1806180", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "Q1ZXE9", "DDB_G0285703", "B0G198", "DDB_G0295683", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403" ] }, "reaction_10620316": { "compartment": "compartment_876", "id": "reaction_10620316", "reactome": "R-DDI-8868236", "name": "BAR domain proteins recruit dynamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620312", "species_10620310" ], "products": [ "species_10620314" ], "modifiers": [], "additional_components": [ "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29438", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "species_179856", "Q54U74", "DDB_G0281235", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q555L8", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q75JD4", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "B0G198", "DDB_G0295683", "Q1ZXE9", "DDB_G0285703", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "species_179856", "Q54U74", "DDB_G0281235", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q555L8", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q75JD4", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "B0G198", "DDB_G0295683", "Q1ZXE9", "DDB_G0285703", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29438" ] }, "reaction_10601617": { "compartment": "compartment_70101", "id": "reaction_10601617", "reactome": "R-DDI-2872497", "name": "SLC17A3-2 transports cytosolic urate to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30034" ], "products": [ "species_429056" ], "modifiers": [ [ "species_10601614", "catalyst" ] ], "additional_components": [ "Q54UX4", "DDB_G0280761", "Q54W37", "DDB_G0280761" ] }, "reaction_10601536": { "compartment": "compartment_70101", "id": "reaction_10601536", "reactome": "R-DDI-2730692", "name": "CLCN4/5/6 exchange Cl- for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_2731008" ], "products": [ "species_74722", "species_352022" ], "modifiers": [ [ "species_10601533", "catalyst" ] ], "additional_components": [ "DDB_G0278639" ] }, "reaction_10627397": { "compartment": "compartment_70101", "id": "reaction_10627397", "reactome": "R-DDI-9701055", "name": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10627394", "catalyst" ], [ "species_10602358", "catalyst" ] ], "additional_components": [ "Q54J43", "DDB_G0288307", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417" ] }, "reaction_10602360": { "compartment": "compartment_70101", "id": "reaction_10602360", "reactome": "R-DDI-3295579", "name": "TRPs transport extracellular Ca2+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10602335", "catalyst" ], [ "species_10602358", "catalyst" ] ], "additional_components": [ "Q54EY0", "DDB_G0291275", "Q54J43", "DDB_G0288307", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417" ] }, "reaction_10601528": { "compartment": "compartment_70101", "id": "reaction_10601528", "reactome": "R-DDI-2684901", "name": "ANOs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10601525", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q54BH1", "DDB_G0293626", "Q55GA1", "DDB_G0293626" ] }, "reaction_10601608": { "compartment": "compartment_70101", "id": "reaction_10601608", "reactome": "R-DDI-2744228", "name": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10601605", "catalyst" ] ], "additional_components": [ "Q54C67", "DDB_G0293130", "Q54LQ4", "DDB_G0286491" ] }, "reaction_10601626": { "compartment": "compartment_70101", "id": "reaction_10601626", "reactome": "R-DDI-2872498", "name": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_83910" ], "products": [ "species_113551", "species_2892454" ], "modifiers": [ [ "species_10601623", "catalyst" ] ], "additional_components": [ "Q54UX4", "DDB_G0280761", "Q54W37", "DDB_G0280761" ] }, "reaction_10627086": { "compartment": "compartment_70101", "id": "reaction_10627086", "reactome": "R-DDI-9659568", "name": "ANO1 transports cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10601485", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q54BH1", "DDB_G0293626", "Q55GA1", "DDB_G0293626" ] }, "reaction_10592547": { "compartment": "compartment_876", "id": "reaction_10592547", "reactome": "R-DDI-444416", "name": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31633" ], "products": [ "species_140912" ], "modifiers": [ [ "species_10592544", "catalyst" ] ], "additional_components": [ "Q8I0L6", "DDB_G0280059", "Q9NIV0", "DDB_G0283389" ] }, "reaction_10592822": { "compartment": "compartment_876", "id": "reaction_10592822", "reactome": "R-DDI-446277", "name": "RhCG mediates ammonium efflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10592535", "catalyst" ] ], "additional_components": [ "Q8I0L6", "DDB_G0280059", "Q9NIV0", "DDB_G0283389" ] }, "reaction_10592552": { "compartment": "compartment_876", "id": "reaction_10592552", "reactome": "R-DDI-444419", "name": "RhBG mediates ammonium effflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10592549", "catalyst" ] ], "additional_components": [ "DDB_G0280059" ] }, "reaction_10592824": { "compartment": "compartment_876", "id": "reaction_10592824", "reactome": "R-DDI-446278", "name": "RhBG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10592549", "catalyst" ] ], "additional_components": [ "DDB_G0280059" ] }, "reaction_10592538": { "compartment": "compartment_876", "id": "reaction_10592538", "reactome": "R-DDI-444393", "name": "RhCG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10592535", "catalyst" ] ], "additional_components": [ "Q8I0L6", "DDB_G0280059", "Q9NIV0", "DDB_G0283389" ] }, "reaction_10592523": { "compartment": "compartment_876", "id": "reaction_10592523", "reactome": "R-DDI-444126", "name": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_432019" ], "products": [ "species_29514" ], "modifiers": [ [ "species_10592520", "catalyst" ] ], "additional_components": [ "Q86AP4", "DDB_G0277263" ] }, "reaction_10591788": { "compartment": "compartment_876", "id": "reaction_10591788", "reactome": "R-DDI-429101", "name": "HMIT co-transports myo-inositol with a proton", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_429130" ], "products": [ "species_70106", "species_426910" ], "modifiers": [ [ "species_10591785", "catalyst" ] ], "additional_components": [ "DDB_G0278261" ] }, "reaction_10592375": { "compartment": "compartment_172574", "id": "reaction_10592375", "reactome": "R-DDI-435171", "name": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_445829" ], "products": [ "species_445832", "species_1470067" ], "modifiers": [ [ "species_10592372", "catalyst" ] ], "additional_components": [ "species_29426", "species_71067", "species_266099", "species_29426", "species_266099", "species_71067", "DDB_G0276973" ] }, "reaction_10592422": { "compartment": "compartment_876", "id": "reaction_10592422", "reactome": "R-DDI-437300", "name": "SLC31A1 transports Cu2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_437295" ], "products": [ "species_209799" ], "modifiers": [ [ "species_10592419", "catalyst" ] ], "additional_components": [ "DDB_G0285545" ] }, "reaction_10624126": { "compartment": "compartment_70101", "id": "reaction_10624126", "reactome": "R-DDI-8959798", "name": "SLC30A10 transports Mn2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29418" ], "products": [ "species_266099" ], "modifiers": [ [ "species_10624123", "catalyst" ] ], "additional_components": [ "DDB_G0282067" ] }, "reaction_10592380": { "compartment": "compartment_876", "id": "reaction_10592380", "reactome": "R-DDI-435349", "name": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_435347" ], "products": [ "species_70106", "species_71067" ], "modifiers": [ [ "species_10592377", "catalyst" ] ], "additional_components": [ "DDB_G0276973" ] }, "reaction_10592367": { "compartment": "compartment_876", "id": "reaction_10592367", "reactome": "R-DDI-434650", "name": "MATEs mediate extrusion of xenobiotics", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_446589" ], "products": [ "species_70106", "species_446597" ], "modifiers": [ [ "species_10592364", "catalyst" ] ], "additional_components": [ "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:641", "CHEBI:6801", "CHEBI:16737", "CHEBI:8428", "CHEBI:42820", "CHEBI:16737", "CHEBI:641", "CHEBI:46020", "CHEBI:6801", "Q54YM8", "DDB_G0292132", "Q54DM2", "DDB_G0292132" ] }, "reaction_10594911": { "compartment": "compartment_70101", "id": "reaction_10594911", "reactome": "R-DDI-927789", "name": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594907", "species_10594881" ], "products": [ "species_10594909" ], "modifiers": [], "additional_components": [ "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q9BMX0", "DDB_G0288613", "Q54KR9", "DDB_G0287197", "Q55D17", "DDB_G0269814", "Q54BM2", "DDB_G0293558", "Q553R3", "DDB_G0275395", "Q7YZN9", "DDB_G0277919", "species_29420", "DDB_G0288923", "Q54I89", "DDB_G0288923", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q9BMX0", "DDB_G0288613", "Q54KR9", "DDB_G0287197", "Q55D17", "DDB_G0269814", "Q54BM2", "DDB_G0293558", "Q553R3", "DDB_G0275395", "Q7YZN9", "DDB_G0277919", "species_29420" ] }, "reaction_10594987": { "compartment": "compartment_70101", "id": "reaction_10594987", "reactome": "R-DDI-927889", "name": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10594982" ], "products": [ "species_29370", "species_10594984" ], "modifiers": [ [ "species_10594982", "catalyst" ] ], "additional_components": [ "Q54I89", "DDB_G0288923", "Q54R12", "DDB_G0283447", "Q75JP6", "DDB_G0272470", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q9BMX0", "DDB_G0288613", "Q54DH9", "DDB_G0292240", "Q54ME8", "DDB_G0286007", "Q55E21", "DDB_G0270866", "Q55D61", "DDB_G0269192", "Q54TQ1", "DDB_G0281623", "Q55A46", "DDB_G0272108", "Q7YZN9", "DDB_G0277919", "species_29420", "Q54KR9", "DDB_G0287197", "Q55D17", "DDB_G0269814", "Q54BM2", "DDB_G0293558", "Q553R3", "DDB_G0275395", "Q54I89", "DDB_G0288923", "Q54R12", "DDB_G0283447", "Q75JP6", "DDB_G0272470", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q9BMX0", "DDB_G0288613", "Q54DH9", "DDB_G0292240", "Q54ME8", "DDB_G0286007", "Q55E21", "DDB_G0270866", "Q55D61", "DDB_G0269192", "Q54TQ1", "DDB_G0281623", "Q55A46", "DDB_G0272108", "Q7YZN9", "DDB_G0277919", "species_29420", "Q54KR9", "DDB_G0287197", "Q55D17", "DDB_G0269814", "Q54BM2", "DDB_G0293558", "Q553R3", "DDB_G0275395", "Q54I89", "DDB_G0288923", "Q54R12", "DDB_G0283447", "Q75JP6", "DDB_G0272470", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q9BMX0", "DDB_G0288613", "Q54DH9", "DDB_G0292240", "Q54ME8", "DDB_G0286007", "Q55E21", "DDB_G0270866", "Q55D61", "DDB_G0269192", "Q54TQ1", "DDB_G0281623", "Q55A46", "DDB_G0272108", "Q7YZN9", "DDB_G0277919", "species_29420", "Q54KR9", "DDB_G0287197", "Q55D17", "DDB_G0269814", "Q54BM2", "DDB_G0293558", "Q553R3", "DDB_G0275395" ] }, "reaction_10582497": { "compartment": "compartment_7660", "id": "reaction_10582497", "reactome": "R-DDI-83790", "name": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582491", "species_10581800" ], "products": [ "species_10582495" ], "modifiers": [], "additional_components": [ "Q8T1F9", "DDB_G0275127", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54YB5", "DDB_G0278321", "Q54FU1", "DDB_G0290591", "Q54U85", "DDB_G0281215", "Q54R53", "DDB_G0283405", "P26355", "DDB_G0275617", "Q54U85", "DDB_G0281215", "Q54R53", "DDB_G0283405", "P26355", "DDB_G0275617", "Q8T1F9", "DDB_G0275127", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54YB5", "DDB_G0278321", "Q54FU1", "DDB_G0290591" ] }, "reaction_10582501": { "compartment": "compartment_7660", "id": "reaction_10582501", "reactome": "R-DDI-83805", "name": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582495", "species_10581897" ], "products": [ "species_10582499" ], "modifiers": [], "additional_components": [ "Q54U85", "DDB_G0281215", "Q54R53", "DDB_G0283405", "P26355", "DDB_G0275617", "Q8T1F9", "DDB_G0275127", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54YB5", "DDB_G0278321", "Q54FU1", "DDB_G0290591", "Q557J3", "DDB_G0273425", "Q54LP2", "DDB_G0286521", "Q54R66", "DDB_G0283365", "Q54IM0", "DDB_G0288665", "Q55FJ5", "DDB_G0268080", "Q86JM3", "DDB_G0272022", "Q54EH2", "DDB_G0291636", "Q54K02", "DDB_G0287707", "Q54SN4", "DDB_G0282339", "Q54FA8", "DDB_G0291037", "Q8T1V7", "DDB_G0277671", "Q86JI9", "DDB_G0271514", "Q55AB6", "DDB_G0272036", "Q86AQ5", "DDB_G0277199", "Q54IZ9", "DDB_G0288449", "Q54YW8", "DDB_G0278039", "Q557J3", "DDB_G0273425", "Q54LP2", "DDB_G0286521", "Q54R66", "DDB_G0283365", "Q54IM0", "DDB_G0288665", "Q55FJ5", "DDB_G0268080", "Q86JM3", "DDB_G0272022", "Q54EH2", "DDB_G0291636", "Q54K02", "DDB_G0287707", "Q54SN4", "DDB_G0282339", "Q54FA8", "DDB_G0291037", "Q8T1V7", "DDB_G0277671", "Q86JI9", "DDB_G0271514", "Q55AB6", "DDB_G0272036", "Q86AQ5", "DDB_G0277199", "Q54IZ9", "DDB_G0288449", "Q54YW8", "DDB_G0278039", "Q54U85", "DDB_G0281215", "Q54R53", "DDB_G0283405", "P26355", "DDB_G0275617", "Q8T1F9", "DDB_G0275127", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54YB5", "DDB_G0278321", "Q54FU1", "DDB_G0290591" ] }, "reaction_10582493": { "compartment": "compartment_7660", "id": "reaction_10582493", "reactome": "R-DDI-83788", "name": "Binding of TFIIIC to Type 2 promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581829", "species_83747" ], "products": [ "species_10582491" ], "modifiers": [], "additional_components": [ "Q8T1F9", "DDB_G0275127", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54YB5", "DDB_G0278321", "Q54FU1", "DDB_G0290591", "Q8T1F9", "DDB_G0275127", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54YB5", "DDB_G0278321", "Q54FU1", "DDB_G0290591" ] }, "reaction_10588590": { "compartment": "compartment_70101", "id": "reaction_10588590", "reactome": "R-DDI-205039", "name": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10588141" ], "products": [ "species_10588143", "species_29420" ], "modifiers": [ [ "species_10588587", "catalyst" ] ], "additional_components": [ "species_29420", "P34144", "DDB_G0277869", "P34144", "DDB_G0277869", "species_29438", "Q54F88", "DDB_G0293396", "Q86HN1", "DDB_G0293396", "Q54G10", "DDB_G0293396", "Q86K95", "DDB_G0293396", "Q54GP2", "DDB_G0293396", "Q54J14", "DDB_G0288377", "Q54NG0", "DDB_G0293396", "Q54P24", "DDB_G0284845", "Q54P81", "DDB_G0293396", "Q54S15", "DDB_G0293396", "Q54SR5", "DDB_G0293396", "Q54VX2", "DDB_G0293396", "Q54XA7", "DDB_G0293396", "Q54XW8", "DDB_G0278703", "Q54BV5", "DDB_G0293396", "Q54YP1", "DDB_G0293396", "Q54BY9", "DDB_G0293396", "Q54YZ6", "DDB_G0277987", "Q54C56", "DDB_G0293396", "Q55DL8", "DDB_G0293396", "Q54DW7", "DDB_G0293396", "Q55G61", "DDB_G0268354", "Q54KI4", "DDB_G0287325", "Q8SSQ0", "DDB_G0274605", "Q54C94", "DDB_G0293006", "Q8IS11", "DDB_G0290267", "Q54FF3", "DDB_G0290901", "Q8SSW7", "DDB_G0271868", "Q8IS14", "DDB_G0277913", "Q8ST25", "DDB_G0272032", "Q54H95", "DDB_G0289613", "Q8IS15", "DDB_G0277915", "Q54PQ4", "DDB_G0284329", "Q8IS16", "DDB_G0276963", "Q54XL4", "DDB_G0289613", "Q8IS20", "DDB_G0282381", "Q55FD8", "DDB_G0268578", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q55GH9", "DDB_G0267666", "Q54SG9", "DDB_G0282475", "Q550V3", "DDB_G0277017", "Q54MM3", "DDB_G0291085", "Q54B37", "DDB_G0293978", "Q54F64", "DDB_G0291085", "Q54PK2", "DDB_G0291085", "Q1ZXN6", "DDB_G0272372", "Q54J11", "DDB_G0288383", "Q54L90", "DDB_G0286773", "Q54WL2", "DDB_G0279569", "Q552M5", "DDB_G0276019", "Q86G47", "DDB_G0289665", "Q8IS18", "DDB_G0269252", "Q8IS19", "DDB_G0289667", "Q8SSQ3", "DDB_G0274607" ] }, "reaction_10626822": { "compartment": "compartment_70101", "id": "reaction_10626822", "reactome": "R-DDI-9647978", "name": "pro-RAS proteins are farnesylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626748", "species_2530486" ], "products": [ "species_111294", "species_10626810" ], "modifiers": [ [ "species_10626817", "catalyst" ], [ "species_10626820", "inhibitor" ] ], "additional_components": [ "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "Q54QY0", "DDB_G0283547", "Q55CB0", "DDB_G0270138", "Q55CA9", "DDB_G0270140", "Q55CB8", "DDB_G0270124", "Q55CB7", "DDB_G0270126", "Q55CC0", "DDB_G0270122", "Q55CB9", "DDB_G0270736", "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "P32252", "DDB_G0292998", "P15064", "DDB_G0293434", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "Q54QY0", "DDB_G0283547", "Q55CB0", "DDB_G0270138", "Q55CA9", "DDB_G0270140", "Q55CB8", "DDB_G0270124", "Q55CB7", "DDB_G0270126", "Q55CC0", "DDB_G0270122", "Q55CB9", "DDB_G0270736", "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "Q54RT9", "DDB_G0283053", "Q55D51", "DDB_G0270948", "Q54RT9", "DDB_G0283053", "Q55D51", "DDB_G0270948" ] }, "reaction_10626891": { "compartment": "compartment_876", "id": "reaction_10626891", "reactome": "R-DDI-9647980", "name": "mature RAS proteins translocate to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626887" ], "products": [ "species_10626889" ], "modifiers": [], "additional_components": [ "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "P32252", "DDB_G0292998", "P15064", "DDB_G0293434", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "Q54QY0", "DDB_G0283547", "Q55CB0", "DDB_G0270138", "Q55CA9", "DDB_G0270140", "Q55CB8", "DDB_G0270124", "Q55CB7", "DDB_G0270126", "Q55CC0", "DDB_G0270122", "Q55CB9", "DDB_G0270736", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140" ] }, "reaction_10626920": { "compartment": "compartment_876", "id": "reaction_10626920", "reactome": "R-DDI-9647991", "name": "Palmostatin B binds RAS depalmitoylases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9647934", "species_10626916" ], "products": [ "species_10626918" ], "modifiers": [], "additional_components": [ "Q54F01", "DDB_G0291205", "Q54T49", "DDB_G0282005", "Q54F01", "DDB_G0291205", "Q54T49", "DDB_G0282005" ] }, "reaction_10626990": { "compartment": "compartment_70101", "id": "reaction_10626990", "reactome": "R-DDI-9653503", "name": "KRAS4B is phosphorylated on serine 181", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10585140" ], "products": [ "species_29370", "species_10626983" ], "modifiers": [ [ "species_10626987", "catalyst" ] ], "additional_components": [ "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "Q55CC0", "DDB_G0270122", "P15064", "DDB_G0293434", "P32253", "DDB_G0281385", "P32252", "DDB_G0292998", "Q75J93", "DDB_G0277381", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q55CA9", "DDB_G0270140", "Q54VD5", "DDB_G0280437", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "P03967", "DDB_G0292996", "Q55CB9", "DDB_G0270736", "Q55CB8", "DDB_G0270124", "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029", "species_30991" ] }, "reaction_10626925": { "compartment": "compartment_876", "id": "reaction_10626925", "reactome": "R-DDI-9647994", "name": "RAS proteins are depalmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10626889" ], "products": [ "species_10626922", "species_8848337" ], "modifiers": [ [ "species_10626916", "catalyst" ], [ "species_10626918", "inhibitor" ] ], "additional_components": [ "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "Q54F01", "DDB_G0291205", "Q54T49", "DDB_G0282005", "Q54F01", "DDB_G0291205", "Q54T49", "DDB_G0282005" ] }, "reaction_10626930": { "compartment": "compartment_876", "id": "reaction_10626930", "reactome": "R-DDI-9649733", "name": "mature p21 RAS binds GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29420", "species_10585142" ], "products": [ "species_10585874" ], "modifiers": [], "additional_components": [ "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29420" ] }, "reaction_10626994": { "compartment": "compartment_876", "id": "reaction_10626994", "reactome": "R-DDI-9653585", "name": "S-Farn-Me KRAS4B binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585140", "species_10583042" ], "products": [ "species_10626992" ], "modifiers": [ [ "species_10626983", "inhibitor" ] ], "additional_components": [ "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "Q55CC0", "DDB_G0270122", "P15064", "DDB_G0293434", "P32253", "DDB_G0281385", "P32252", "DDB_G0292998", "Q75J93", "DDB_G0277381", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q55CA9", "DDB_G0270140", "Q54VD5", "DDB_G0280437", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "P03967", "DDB_G0292996", "Q55CB9", "DDB_G0270736", "Q55CB8", "DDB_G0270124" ] }, "reaction_10627027": { "compartment": "compartment_17906", "id": "reaction_10627027", "reactome": "R-DDI-9653592", "name": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626983" ], "products": [ "species_10627025" ], "modifiers": [], "additional_components": [ "Q55CC0", "DDB_G0270122", "P15064", "DDB_G0293434", "P32253", "DDB_G0281385", "P32252", "DDB_G0292998", "Q75J93", "DDB_G0277381", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q55CA9", "DDB_G0270140", "Q54VD5", "DDB_G0280437", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "P03967", "DDB_G0292996", "Q55CB9", "DDB_G0270736", "Q55CB8", "DDB_G0270124", "Q55CA9", "DDB_G0270140", "Q54VD5", "DDB_G0280437", "Q55CB7", "DDB_G0270126", "Q55CB0", "DDB_G0270138", "Q55CB9", "DDB_G0270736", "Q55CB8", "DDB_G0270124", "Q75J93", "DDB_G0277381", "Q55CC0", "DDB_G0270122", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P32253", "DDB_G0281385", "P32252", "DDB_G0292998", "Q54QY0", "DDB_G0283547", "P32254", "DDB_G0283537" ] }, "reaction_10626928": { "compartment": "compartment_12045", "id": "reaction_10626928", "reactome": "R-DDI-9649732", "name": "Mature S-Farn-Me KRAS4B translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626679" ], "products": [ "species_10585140" ], "modifiers": [], "additional_components": [ "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "Q54QY0", "DDB_G0283547", "Q55CB0", "DDB_G0270138", "Q55CA9", "DDB_G0270140", "Q55CB8", "DDB_G0270124", "Q55CB7", "DDB_G0270126", "Q55CC0", "DDB_G0270122", "Q55CB9", "DDB_G0270736", "Q75J93", "DDB_G0277381", "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "P03967", "DDB_G0292996", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385" ] }, "reaction_10626903": { "compartment": "compartment_20699", "id": "reaction_10626903", "reactome": "R-DDI-9647982", "name": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626681", "species_200993" ], "products": [ "species_10626887", "species_76194" ], "modifiers": [ [ "species_10626900", "catalyst" ] ], "additional_components": [ "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "Q54QY0", "DDB_G0283547", "Q55CB0", "DDB_G0270138", "Q55CA9", "DDB_G0270140", "Q55CB8", "DDB_G0270124", "Q55CB7", "DDB_G0270126", "Q55CC0", "DDB_G0270122", "Q55CB9", "DDB_G0270736", "Q75J93", "DDB_G0277381", "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "P32252", "DDB_G0292998", "P15064", "DDB_G0293434", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "Q54QY0", "DDB_G0283547", "Q55CB0", "DDB_G0270138", "Q55CA9", "DDB_G0270140", "Q55CB8", "DDB_G0270124", "Q55CB7", "DDB_G0270126", "Q55CC0", "DDB_G0270122", "Q55CB9", "DDB_G0270736", "Q54RL6", "DDB_G0283039", "Q550I3", "DDB_G0277093" ] }, "reaction_10627061": { "compartment": "compartment_876", "id": "reaction_10627061", "reactome": "R-DDI-9654521", "name": "Calmodulin dissociates KRAS4B from the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626992" ], "products": [ "species_10627059" ], "modifiers": [], "additional_components": [ "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "Q55CA9", "DDB_G0270140", "Q54VD5", "DDB_G0280437", "Q55CB7", "DDB_G0270126", "Q55CB0", "DDB_G0270138", "Q55CB9", "DDB_G0270736", "Q55CB8", "DDB_G0270124", "Q75J93", "DDB_G0277381", "Q55CC0", "DDB_G0270122", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P32253", "DDB_G0281385", "P32252", "DDB_G0292998", "Q54QY0", "DDB_G0283547", "P32254", "DDB_G0283537" ] }, "reaction_10626905": { "compartment": "compartment_70101", "id": "reaction_10626905", "reactome": "R-DDI-9647987", "name": "FNTB inhibitors bind FNTA:FNTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9653479", "species_10626817" ], "products": [ "species_10626820" ], "modifiers": [], "additional_components": [ "Q54RT9", "DDB_G0283053", "Q55D51", "DDB_G0270948", "Q54RT9", "DDB_G0283053", "Q55D51", "DDB_G0270948" ] }, "reaction_10626685": { "compartment": "compartment_12045", "id": "reaction_10626685", "reactome": "R-DDI-9647977", "name": "ICMT methylates S-Farn RAS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626649", "species_71284" ], "products": [ "species_10626681", "species_71285" ], "modifiers": [ [ "species_10612819", "catalyst" ], [ "species_10626683", "inhibitor" ] ], "additional_components": [ "P15064", "DDB_G0293434", "Q55CA9", "DDB_G0270140", "Q54VD5", "DDB_G0280437", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "P03967", "DDB_G0292996", "Q55CB9", "DDB_G0270736", "Q55CB8", "DDB_G0270124", "Q55CC0", "DDB_G0270122", "P32253", "DDB_G0281385", "P32252", "DDB_G0292998", "Q75J93", "DDB_G0277381", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "Q54QY0", "DDB_G0283547", "Q55CB0", "DDB_G0270138", "Q55CA9", "DDB_G0270140", "Q55CB8", "DDB_G0270124", "Q55CB7", "DDB_G0270126", "Q55CC0", "DDB_G0270122", "Q55CB9", "DDB_G0270736", "Q75J93", "DDB_G0277381", "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "P03967", "DDB_G0292996", "Q558K8", "DDB_G0272799", "species_29426", "Q558K8", "DDB_G0272799", "species_29426" ] }, "reaction_10607347": { "compartment": "compartment_876", "id": "reaction_10607347", "reactome": "R-DDI-5675417", "name": "PEBP1 binds activated RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607343", "species_10607338" ], "products": [ "species_10607345" ], "modifiers": [], "additional_components": [ "DDB_G0283803", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54QK0", "DDB_G0283803" ] }, "reaction_10607267": { "compartment": "compartment_876", "id": "reaction_10607267", "reactome": "R-DDI-5674018", "name": "BRAP binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607263", "species_10585144" ], "products": [ "species_10607265" ], "modifiers": [], "additional_components": [ "DDB_G0270200", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q55C68", "DDB_G0270200" ] }, "reaction_10607319": { "compartment": "compartment_20699", "id": "reaction_10607319", "reactome": "R-DDI-5674140", "name": "PAQR3 binds inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606974", "species_10607315" ], "products": [ "species_10607317" ], "modifiers": [], "additional_components": [ "DDB_G0281557", "Q54FT1", "DDB_G0293838", "Q54B86", "DDB_G0293838", "Q54CB4", "DDB_G0293838", "Q54FT1", "DDB_G0293838", "Q54B86", "DDB_G0293838", "Q54CB4", "DDB_G0293838", "Q54TM7", "DDB_G0281557" ] }, "reaction_10607367": { "compartment": "compartment_876", "id": "reaction_10607367", "reactome": "R-DDI-5675433", "name": "PP5 dephosphorylates RAF1 S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10607338" ], "products": [ "species_29372", "species_10607351" ], "modifiers": [ [ "species_10607364", "catalyst" ] ], "additional_components": [ "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "DDB_G0283157" ] }, "reaction_10607271": { "compartment": "compartment_70101", "id": "reaction_10607271", "reactome": "R-DDI-5674019", "name": "BRAP binds KSR1:MARK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606927", "species_10607263" ], "products": [ "species_10607269" ], "modifiers": [], "additional_components": [ "Q1ZXD6", "DDB_G0294533", "Q54WS5", "DDB_G0279417", "Q23915", "DDB_G0283391", "Q869X3", "DDB_G0282895", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54VC0", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "DDB_G0270200", "Q55C68", "DDB_G0270200", "Q1ZXD6", "DDB_G0294533", "Q54WS5", "DDB_G0279417", "Q23915", "DDB_G0283391", "Q869X3", "DDB_G0282895", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54VC0", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304" ] }, "reaction_10607279": { "compartment": "compartment_876", "id": "reaction_10607279", "reactome": "R-DDI-5674022", "name": "BRAP autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10607265" ], "products": [ "species_10607276" ], "modifiers": [ [ "species_10607265", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q55C68", "DDB_G0270200", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q55C68", "DDB_G0270200", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q55C68", "DDB_G0270200" ] }, "reaction_10607358": { "compartment": "compartment_876", "id": "reaction_10607358", "reactome": "R-DDI-5675431", "name": "PP2A dephosphorylates RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10607351" ], "products": [ "species_29372", "species_10607355" ], "modifiers": [ [ "species_10590274", "catalyst" ], [ "species_10607330", "catalyst" ] ], "additional_components": [ "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "DDB_G0281557" ] }, "reaction_10626932": { "compartment": "compartment_876", "id": "reaction_10626932", "reactome": "R-DDI-9649735", "name": "Intrinsic nucleotide exchange on RAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10585874" ], "products": [ "species_29420", "species_10585144" ], "modifiers": [], "additional_components": [ "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29420", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438" ] }, "reaction_10627146": { "compartment": "compartment_876", "id": "reaction_10627146", "reactome": "R-DDI-9660557", "name": "RAS:GTP binds RAL GDS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627140", "species_10627142" ], "products": [ "species_10627144" ], "modifiers": [], "additional_components": [ "Q8SSQ3", "DDB_G0274607", "Q54WL2", "DDB_G0279569", "Q54L90", "DDB_G0286773", "Q86G47", "DDB_G0289665", "Q552M5", "DDB_G0276019", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "P15064", "DDB_G0293434", "species_29438", "P15064", "DDB_G0293434", "species_29438", "Q8SSQ3", "DDB_G0274607", "Q54WL2", "DDB_G0279569", "Q54L90", "DDB_G0286773", "Q86G47", "DDB_G0289665", "Q552M5", "DDB_G0276019", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252" ] }, "reaction_10626937": { "compartment": "compartment_876", "id": "reaction_10626937", "reactome": "R-DDI-9649736", "name": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585144" ], "products": [ "species_10585874" ], "modifiers": [ [ "species_10585144", "catalyst" ] ], "additional_components": [ "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29420", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438" ] }, "reaction_10607066": { "compartment": "compartment_876", "id": "reaction_10607066", "reactome": "R-DDI-5672965", "name": "RAS GEFs promote RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10585874" ], "products": [ "species_29420", "species_10585144" ], "modifiers": [ [ "species_10607063", "catalyst" ] ], "additional_components": [ "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29420", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q8IS14", "DDB_G0277913", "Q8IS15", "DDB_G0277915", "Q8IS16", "DDB_G0276963", "Q8IS20", "DDB_G0282381", "Q8IS21", "DDB_G0269222", "Q8SSQ0", "DDB_G0274605", "Q8SSW7", "DDB_G0271868", "B0M0P8", "DDB_G0276371", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q54FF3", "DDB_G0290901", "Q54H95", "DDB_G0289613", "Q54PQ4", "DDB_G0284329", "Q54XL4", "DDB_G0289613", "Q55FD8", "DDB_G0268578", "Q55GH9", "DDB_G0267666", "Q8IS11", "DDB_G0290267", "species_6797635", "Q54TK8", "DDB_G0281573", "Q8IS12", "DDB_G0275703", "Q54L90", "DDB_G0286773", "Q54WL2", "DDB_G0279569", "Q552M5", "DDB_G0276019", "Q86G47", "DDB_G0289665", "Q8IS18", "DDB_G0269252", "Q8IS19", "DDB_G0289667", "Q8SSQ3", "DDB_G0274607" ] }, "reaction_10626939": { "compartment": "compartment_876", "id": "reaction_10626939", "reactome": "R-DDI-9653108", "name": "Raf dimer inhibitors bind RAF heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607149", "species_9657579" ], "products": [ "species_10607251" ], "modifiers": [], "additional_components": [ "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438" ] }, "reaction_10606970": { "compartment": "compartment_70101", "id": "reaction_10606970", "reactome": "R-DDI-5672948", "name": "MARK3 phosphorylates KSR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606927", "species_113592" ], "products": [ "species_29370", "species_10606967" ], "modifiers": [ [ "species_10606927", "catalyst" ] ], "additional_components": [ "Q1ZXD6", "DDB_G0294533", "Q54WS5", "DDB_G0279417", "Q23915", "DDB_G0283391", "Q869X3", "DDB_G0282895", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54VC0", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q1ZXD6", "DDB_G0294533", "Q54RZ7", "DDB_G0282895", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54TH6", "DDB_G0282895", "Q54GY6", "DDB_G0289859", "Q54VC0", "DDB_G0282895", "Q54H05", "DDB_G0289661", "Q54WS5", "DDB_G0279417", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q1ZXD6", "DDB_G0294533", "Q54WS5", "DDB_G0279417", "Q23915", "DDB_G0283391", "Q869X3", "DDB_G0282895", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54VC0", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304" ] }, "reaction_10606562": { "compartment": "compartment_70101", "id": "reaction_10606562", "reactome": "R-DDI-5658424", "name": "KBTBD7:CUL3:RBX1 ubiquitinates NF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10606525" ], "products": [ "species_10606557" ], "modifiers": [ [ "species_10606559", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q5TJ65", "DDB_G0289541", "Q54WD0", "DDB_G0282941", "Q54Y08", "DDB_G0278483", "Q55AR6", "DDB_G0271750", "Q86JJ7", "DDB_G0282941", "Q8SSU4", "DDB_G0282941", "Q54Q13", "DDB_G0284177", "Q54RT3", "DDB_G0282941", "Q5TJ65", "DDB_G0289541", "Q54Y08", "DDB_G0278483", "Q55AR6", "DDB_G0271750", "Q54Q13", "DDB_G0284177", "Q86JJ7", "DDB_G0282941", "Q8SSU4", "DDB_G0282941", "Q54RT3", "DDB_G0282941", "Q54WD0", "DDB_G0282941", "Q55BF8", "DDB_G0271372", "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903" ] }, "reaction_10606532": { "compartment": "compartment_876", "id": "reaction_10606532", "reactome": "R-DDI-5658231", "name": "RAS GAPs stimulate RAS GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606529" ], "products": [ "species_10606527", "species_10585874" ], "modifiers": [ [ "species_10606529", "catalyst" ] ], "additional_components": [ "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54Q13", "DDB_G0284177", "Q86JJ7", "DDB_G0282941", "Q54WD0", "DDB_G0282941", "Q54Y08", "DDB_G0278483", "Q8SSU4", "DDB_G0282941", "Q54RT3", "DDB_G0282941", "Q55AR6", "DDB_G0271750", "Q5TJ65", "DDB_G0289541", "Q54Q13", "DDB_G0284177", "Q86JJ7", "DDB_G0282941", "Q54WD0", "DDB_G0282941", "Q54Y08", "DDB_G0278483", "Q8SSU4", "DDB_G0282941", "Q54RT3", "DDB_G0282941", "Q55AR6", "DDB_G0271750", "Q5TJ65", "DDB_G0289541", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29420", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54Q13", "DDB_G0284177", "Q86JJ7", "DDB_G0282941", "Q54WD0", "DDB_G0282941", "Q54Y08", "DDB_G0278483", "Q8SSU4", "DDB_G0282941", "Q54RT3", "DDB_G0282941", "Q55AR6", "DDB_G0271750", "Q5TJ65", "DDB_G0289541" ] }, "reaction_10606564": { "compartment": "compartment_70101", "id": "reaction_10606564", "reactome": "R-DDI-5658430", "name": "NF1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606557" ], "products": [ "species_10606507" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q5TJ65", "DDB_G0289541", "Q54Y08", "DDB_G0278483", "Q55AR6", "DDB_G0271750", "Q54Q13", "DDB_G0284177", "Q86JJ7", "DDB_G0282941", "Q8SSU4", "DDB_G0282941", "Q54RT3", "DDB_G0282941", "Q54WD0", "DDB_G0282941", "Q5TJ65", "DDB_G0289541", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10606566": { "compartment": "compartment_876", "id": "reaction_10606566", "reactome": "R-DDI-5658435", "name": "RAS GAPs bind RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606527", "species_10585144" ], "products": [ "species_10606529" ], "modifiers": [], "additional_components": [ "Q54Q13", "DDB_G0284177", "Q86JJ7", "DDB_G0282941", "Q54WD0", "DDB_G0282941", "Q54Y08", "DDB_G0278483", "Q8SSU4", "DDB_G0282941", "Q54RT3", "DDB_G0282941", "Q55AR6", "DDB_G0271750", "Q5TJ65", "DDB_G0289541", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54Q13", "DDB_G0284177", "Q86JJ7", "DDB_G0282941", "Q54WD0", "DDB_G0282941", "Q54Y08", "DDB_G0278483", "Q8SSU4", "DDB_G0282941", "Q54RT3", "DDB_G0282941", "Q55AR6", "DDB_G0271750", "Q5TJ65", "DDB_G0289541" ] }, "reaction_10606568": { "compartment": "compartment_876", "id": "reaction_10606568", "reactome": "R-DDI-5658438", "name": "SPRED dimer binds NF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606523", "species_10606507" ], "products": [ "species_10606525" ], "modifiers": [], "additional_components": [ "Q54WD0", "DDB_G0282941", "Q54Y08", "DDB_G0278483", "Q55AR6", "DDB_G0271750", "Q86JJ7", "DDB_G0282941", "Q8SSU4", "DDB_G0282941", "Q54Q13", "DDB_G0284177", "Q54RT3", "DDB_G0282941", "Q5TJ65", "DDB_G0289541", "Q5TJ65", "DDB_G0289541", "Q54WD0", "DDB_G0282941", "Q54Y08", "DDB_G0278483", "Q55AR6", "DDB_G0271750", "Q86JJ7", "DDB_G0282941", "Q8SSU4", "DDB_G0282941", "Q54Q13", "DDB_G0284177", "Q54RT3", "DDB_G0282941" ] }, "reaction_10583296": { "compartment": "compartment_7660", "id": "reaction_10583296", "reactome": "R-DDI-112392", "name": "Resumption of elongation after recovery from pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583294" ], "products": [ "species_10583290" ], "modifiers": [], "additional_components": [ "Q75JA4", "DDB_G0271690", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10583300": { "compartment": "compartment_7660", "id": "reaction_10583300", "reactome": "R-DDI-112395", "name": "Abortive termination of elongation after arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583290" ], "products": [ "species_10583298" ], "modifiers": [], "additional_components": [ "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q75JA4", "DDB_G0271690", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10581640": { "compartment": "compartment_7660", "id": "reaction_10581640", "reactome": "R-DDI-75862", "name": "Fall Back to Closed Pre-initiation Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581630" ], "products": [ "species_10581638" ], "modifiers": [], "additional_components": [ "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54FD6", "DDB_G0290929", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307" ] }, "reaction_10581740": { "compartment": "compartment_7660", "id": "reaction_10581740", "reactome": "R-DDI-75891", "name": "Abortive Initiation After Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581738" ], "products": [ "species_10580922", "species_10580699", "species_10578889", "species_75897" ], "modifiers": [], "additional_components": [ "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10583308": { "compartment": "compartment_7660", "id": "reaction_10583308", "reactome": "R-DDI-112429", "name": "Formation of FACT complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583209", "species_10583204" ], "products": [ "species_10583211" ], "modifiers": [], "additional_components": [ "DDB_G0282677", "DDB_G0290331", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677" ] }, "reaction_10583310": { "compartment": "compartment_7660", "id": "reaction_10583310", "reactome": "R-DDI-112430", "name": "Formation of P-TEFb complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583129", "species_10583140" ], "products": [ "species_10583142" ], "modifiers": [], "additional_components": [ "DDB_G0273207", "Q54LJ0", "DDB_G0286617", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207" ] }, "reaction_10583312": { "compartment": "compartment_7660", "id": "reaction_10583312", "reactome": "R-DDI-112434", "name": "Formation of DSIF complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582382", "species_10583163" ], "products": [ "species_10583165" ], "modifiers": [], "additional_components": [ "DDB_G0287661", "DDB_G0285293", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661" ] }, "reaction_10583316": { "compartment": "compartment_7660", "id": "reaction_10583316", "reactome": "R-DDI-113409", "name": "Abortive termination of early transcription elongation by DSIF:NELF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583219" ], "products": [ "species_10583219" ], "modifiers": [], "additional_components": [ "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q75JA4", "DDB_G0271690", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q75JA4", "DDB_G0271690", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195" ] }, "reaction_10583318": { "compartment": "compartment_7660", "id": "reaction_10583318", "reactome": "R-DDI-113411", "name": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583290" ], "products": [ "species_10583294" ], "modifiers": [], "additional_components": [ "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q75JA4", "DDB_G0271690", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10583322": { "compartment": "compartment_7660", "id": "reaction_10583322", "reactome": "R-DDI-113413", "name": "TFIIS-mediated recovery of elongation from arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583290" ], "products": [ "species_10583290" ], "modifiers": [], "additional_components": [ "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10581628": { "compartment": "compartment_7660", "id": "reaction_10581628", "reactome": "R-DDI-75856", "name": "Abortive Initiation Before Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581626" ], "products": [ "species_10580910", "species_10580844", "species_10580922", "species_10580699", "species_10578889", "species_10580839", "species_110068" ], "modifiers": [], "additional_components": [ "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "DDB_G0290929", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343" ] }, "reaction_10583324": { "compartment": "compartment_7660", "id": "reaction_10583324", "reactome": "R-DDI-113414", "name": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583290" ], "products": [ "species_10583290" ], "modifiers": [], "additional_components": [ "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10580926": { "compartment": "compartment_7660", "id": "reaction_10580926", "reactome": "R-DDI-73946", "name": "Abortive initiation after formation of the first phosphodiester bond", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580924" ], "products": [ "species_10580910", "species_10580844", "species_10580922", "species_10580699", "species_10578889", "species_10580839", "species_109877" ], "modifiers": [], "additional_components": [ "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "DDB_G0290929", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343" ] }, "reaction_10626417": { "compartment": "compartment_17938", "id": "reaction_10626417", "reactome": "R-DDI-9639287", "name": "SESN1,2 binds L-leucine and dissociates from GATOR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626411", "species_29588" ], "products": [ "species_10626413", "species_10626415" ], "modifiers": [], "additional_components": [ "Q54WU6", "DDB_G0279427", "Q86K39", "DDB_G0277257", "Q54JS5", "DDB_G0287817", "Q54DS4", "DDB_G0292056", "Q54DS8", "DDB_G0292052", "Q551B5", "DDB_G0276673", "Q54XA2", "DDB_G0279099", "Q55BD9", "DDB_G0271288", "Q54UN5", "DDB_G0280947", "Q54NW3", "DDB_G0284957", "Q54Y15", "DDB_G0278475", "Q86IH5", "DDB_G0272696", "Q55DE8", "DDB_G0269680", "Q54XA2", "DDB_G0279099", "Q55BD9", "DDB_G0271288", "Q54UN5", "DDB_G0280947", "Q54NW3", "DDB_G0284957", "Q54Y15", "DDB_G0278475", "Q86IH5", "DDB_G0272696", "Q55DE8", "DDB_G0269680", "Q86K39", "DDB_G0277257", "Q54JS5", "DDB_G0287817", "Q54DS4", "DDB_G0292056", "Q54DS8", "DDB_G0292052", "Q551B5", "DDB_G0276673", "species_29588", "Q54WU6", "DDB_G0279427" ] }, "reaction_10626343": { "compartment": "compartment_17938", "id": "reaction_10626343", "reactome": "R-DDI-9639286", "name": "RRAGC,D exchanges GTP for GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584158", "species_10626430" ], "products": [ "species_10626432" ], "modifiers": [], "additional_components": [ "Q54DD9", "DDB_G0292318", "species_29438", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q55AH5", "DDB_G0271882", "Q86A77", "DDB_G0274331", "O00780", "DDB_G0275701", "Q54Z13", "DDB_G0277971", "Q76NU1", "DDB_G0277401", "P54648", "DDB_G0284473", "Q86AS7", "DDB_G0274141", "Q54E04", "DDB_G0291858", "P54642", "DDB_G0274381", "P54641", "DDB_G0273071", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q55AH5", "DDB_G0271882", "Q86A77", "DDB_G0274331", "O00780", "DDB_G0275701", "Q54Z13", "DDB_G0277971", "Q76NU1", "DDB_G0277401", "P54648", "DDB_G0284473", "Q86AS7", "DDB_G0274141", "Q54E04", "DDB_G0291858", "P54642", "DDB_G0274381", "P54641", "DDB_G0273071", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q54DD9", "DDB_G0292318" ] }, "reaction_10626428": { "compartment": "compartment_17938", "id": "reaction_10626428", "reactome": "R-DDI-9640167", "name": "RRAGA,B exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10626421" ], "products": [ "species_29420", "species_10626425" ], "modifiers": [ [ "species_10626421", "catalyst" ] ], "additional_components": [ "species_29468", "Q54IK1", "DDB_G0288701", "species_29420", "Q54PK6", "DDB_G0284495", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q55AH5", "DDB_G0271882", "Q86A77", "DDB_G0274331", "O00780", "DDB_G0275701", "Q54Z13", "DDB_G0277971", "Q76NU1", "DDB_G0277401", "P54648", "DDB_G0284473", "Q86AS7", "DDB_G0274141", "Q54E04", "DDB_G0291858", "P54642", "DDB_G0274381", "P54641", "DDB_G0273071", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "species_29468", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q55AH5", "DDB_G0271882", "Q86A77", "DDB_G0274331", "O00780", "DDB_G0275701", "Q54Z13", "DDB_G0277971", "Q76NU1", "DDB_G0277401", "P54648", "DDB_G0284473", "Q86AS7", "DDB_G0274141", "Q54E04", "DDB_G0291858", "P54642", "DDB_G0274381", "P54641", "DDB_G0273071", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "species_29468", "Q54IK1", "DDB_G0288701", "species_29420", "Q54PK6", "DDB_G0284495", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q55AH5", "DDB_G0271882", "Q86A77", "DDB_G0274331", "O00780", "DDB_G0275701", "Q54Z13", "DDB_G0277971", "Q76NU1", "DDB_G0277401", "P54648", "DDB_G0284473", "Q86AS7", "DDB_G0274141", "Q54E04", "DDB_G0291858", "P54642", "DDB_G0274381", "P54641", "DDB_G0273071", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567" ] }, "reaction_10606133": { "compartment": "compartment_7660", "id": "reaction_10606133", "reactome": "R-DDI-5635854", "name": "GLI2,3 are degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606131" ], "products": [ "species_10576865", "species_10606129" ], "modifiers": [ [ "species_10585327", "catalyst" ] ], "additional_components": [ "Q54D90", "DDB_G0292428", "Q54WU7", "DDB_G0292428", "Q55E93", "DDB_G0269338", "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54D90", "DDB_G0292428", "Q54WU7", "DDB_G0292428", "Q55E93", "DDB_G0269338", "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903", "Q27563", "DDB_G0267408", "P02889", "DDB_G0272564", "P34119", "DDB_G0280969", "Q552Y8", "DDB_G0275753", "Q55G04", "DDB_G0268538", "Q967U1", "DDB_G0285099", "Q54XM7", "DDB_G0278847", "P34120", "DDB_G0272831", "Q86A21", "DDB_G0272969", "Q54S82", "DDB_G0282617", "Q54QR2", "DDB_G0283679", "Q55DY7", "DDB_G0269472", "Q55D66", "DDB_G0269772", "Q556Q0", "DDB_G0273163", "Q54BC8", "DDB_G0293784", "Q55GJ6", "DDB_G0267390", "Q55BV5", "DDB_G0270784", "Q86JA1", "DDB_G0276917", "Q54PN7", "DDB_G0284415", "P34123", "DDB_G0289003", "P34124", "DDB_G0292382", "Q54PJ1", "DDB_G0284517", "Q54JM5", "DDB_G0287953", "Q54HW1", "DDB_G0289189", "Q54UB5", "DDB_G0281315", "Q54UJ0", "DDB_G0281051", "Q54NQ0", "DDB_G0285105", "Q54BC6", "DDB_G0293752", "Q1ZXD3", "DDB_G0288621", "Q553E0", "DDB_G0275775", "Q86IJ1", "DDB_G0272566", "Q559F4", "DDB_G0272951", "Q27562", "DDB_G0282363", "Q55C75", "DDB_G0270188", "Q54DM7", "DDB_G0292122", "Q54WI8", "DDB_G0279633" ] }, "reaction_10606140": { "compartment": "compartment_7660", "id": "reaction_10606140", "reactome": "R-DDI-5635856", "name": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606137", "species_10576865" ], "products": [ "species_10606131" ], "modifiers": [ [ "species_10606137", "catalyst" ] ], "additional_components": [ "Q54D90", "DDB_G0292428", "Q54WU7", "DDB_G0292428", "Q55E93", "DDB_G0269338", "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54D90", "DDB_G0292428", "Q54WU7", "DDB_G0292428", "Q55E93", "DDB_G0269338", "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903", "Q54D90", "DDB_G0292428", "Q54WU7", "DDB_G0292428", "Q55E93", "DDB_G0269338", "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903" ] }, "reaction_10595044": { "compartment": "compartment_70101", "id": "reaction_10595044", "reactome": "R-DDI-936563", "name": "ISGylation of DDX58", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10595002", "species_10595040" ], "products": [ "species_10595042" ], "modifiers": [], "additional_components": [ "DDB_G0294407", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q55C16", "DDB_G0270272", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q55C16", "DDB_G0270272", "Q86L44", "DDB_G0294407" ] }, "reaction_10605345": { "compartment": "compartment_12045", "id": "reaction_10605345", "reactome": "R-DDI-5362412", "name": "SYVN1 ubiquitinates Hh C-terminal fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10605338" ], "products": [ "species_10605342" ], "modifiers": [ [ "species_10605338", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q86H64", "DDB_G0275851", "Q54IC9", "DDB_G0288833", "P90532", "DDB_G0288065", "Q54JQ6", "DDB_G0287847", "Q55E19", "DDB_G0269430", "Q54IC9", "DDB_G0288833", "P90532", "DDB_G0288065", "Q54JQ6", "DDB_G0287847", "Q55E19", "DDB_G0269430", "Q86H64", "DDB_G0275851", "Q86H64", "DDB_G0275851", "Q54IC9", "DDB_G0288833", "P90532", "DDB_G0288065", "Q54JQ6", "DDB_G0287847", "Q55E19", "DDB_G0269430" ] }, "reaction_10593912": { "compartment": "compartment_876", "id": "reaction_10593912", "reactome": "R-DDI-507868", "name": "Aquaporins passively transport water into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10593909", "catalyst" ] ], "additional_components": [ "Q9U8P7", "DDB_G0267378", "Q54WT8", "DDB_G0279443", "Q54FQ9", "DDB_G0290691", "Q54V53", "DDB_G0280537" ] }, "reaction_10593914": { "compartment": "compartment_876", "id": "reaction_10593914", "reactome": "R-DDI-507870", "name": "Aquaporins passively transport water out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10593909", "catalyst" ] ], "additional_components": [ "Q9U8P7", "DDB_G0267378", "Q54WT8", "DDB_G0279443", "Q54FQ9", "DDB_G0290691", "Q54V53", "DDB_G0280537" ] }, "reaction_10587219": { "compartment": "compartment_876", "id": "reaction_10587219", "reactome": "R-DDI-199443", "name": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587026", "species_10587009" ], "products": [ "species_10587028" ], "modifiers": [], "additional_components": [ "DDB_G0273293", "species_179838", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_179838", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "Q556W3", "DDB_G0273293" ] }, "reaction_10619666": { "compartment": "compartment_984", "id": "reaction_10619666", "reactome": "R-DDI-8862300", "name": "LYZ binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6789198", "species_10614528" ], "products": [ "species_10619664" ], "modifiers": [], "additional_components": [ "Q54F36", "DDB_G0291137", "Q54XV8", "DDB_G0278563", "Q8MML4", "DDB_G0274551", "Q54F36", "DDB_G0291137", "Q54XV8", "DDB_G0278563", "Q8MML4", "DDB_G0274551", "species_6789198" ] }, "reaction_10619669": { "compartment": "compartment_984", "id": "reaction_10619669", "reactome": "R-DDI-8862320", "name": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10619664" ], "products": [ "species_6788991", "species_6788982" ], "modifiers": [ [ "species_10619664", "catalyst" ] ], "additional_components": [ "Q54F36", "DDB_G0291137", "Q54XV8", "DDB_G0278563", "Q8MML4", "DDB_G0274551", "species_6789198", "species_1236719", "CHEBI:21615", "Q54F36", "DDB_G0291137", "Q54XV8", "DDB_G0278563", "Q8MML4", "DDB_G0274551", "species_6789198" ] }, "reaction_10616763": { "compartment": "compartment_984", "id": "reaction_10616763", "reactome": "R-DDI-6807585", "name": "BPI binds LPS on the bacterial surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803081", "species_10584365" ], "products": [ "species_10616761" ], "modifiers": [], "additional_components": [ "DDB_G0271242", "Q55BA2", "DDB_G0271242", "species_166005" ] }, "reaction_10603621": { "compartment": "compartment_7660", "id": "reaction_10603621", "reactome": "R-DDI-4411373", "name": "NLK translocates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603605" ], "products": [ "species_10603619" ], "modifiers": [], "additional_components": [ "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "P42525", "DDB_G0286353", "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q54US6", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54V83", "DDB_G0280855", "Q554L2", "DDB_G0280855" ] }, "reaction_10603684": { "compartment": "compartment_70101", "id": "reaction_10603684", "reactome": "R-DDI-4551465", "name": "Translocation of NFATC1:CaN:CaM to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603678" ], "products": [ "species_10603682" ], "modifiers": [], "additional_components": [ "species_74112", "Q55G87", "DDB_G0267446", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "species_29426", "Q7YSW8", "DDB_G0276883", "CHEBI:29034", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "species_74112", "Q7YSW8", "DDB_G0276883", "CHEBI:29034", "species_29426", "Q55G87", "DDB_G0267446" ] }, "reaction_10603543": { "compartment": "compartment_70101", "id": "reaction_10603543", "reactome": "R-DDI-4086392", "name": "PDE6 hydrolyses cGMP to GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30991", "species_29356" ], "products": [ "species_113578" ], "modifiers": [ [ "species_10603540", "catalyst" ] ], "additional_components": [ "B0G0Y8", "DDB_G0268634", "species_29438", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343" ] }, "reaction_10622131": { "compartment": "compartment_70101", "id": "reaction_10622131", "reactome": "R-DDI-8875871", "name": "SLC26A11 transports SO4(2-) from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648" ], "products": [ "species_174375" ], "modifiers": [ [ "species_10622128", "catalyst" ] ], "additional_components": [ "DDB_G0268074" ] }, "reaction_10591543": { "compartment": "compartment_876", "id": "reaction_10591543", "reactome": "R-DDI-427666", "name": "SLC26A3,6 exchange Cl- for HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_111627" ], "products": [ "species_425425", "species_352022" ], "modifiers": [ [ "species_10591540", "catalyst" ] ], "additional_components": [ "Q55FK8", "DDB_G0286611", "B0G157", "DDB_G0286611" ] }, "reaction_10591526": { "compartment": "compartment_876", "id": "reaction_10591526", "reactome": "R-DDI-427570", "name": "Group 3 - Selective Cl- transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10591523", "catalyst" ] ], "additional_components": [ "B0G157", "DDB_G0286611", "Q55FK8", "DDB_G0286611" ] }, "reaction_10605910": { "compartment": "compartment_70101", "id": "reaction_10605910", "reactome": "R-DDI-5627802", "name": "SLC26A4 transports I- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209785" ], "products": [ "species_209818" ], "modifiers": [ [ "species_10605907", "catalyst" ] ], "additional_components": [ "Q55FK8", "DDB_G0286611", "B0G157", "DDB_G0286611" ] }, "reaction_10605187": { "compartment": "compartment_70101", "id": "reaction_10605187", "reactome": "R-DDI-5340130", "name": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428040", "species_5673778" ], "products": [ "species_70106", "species_379444" ], "modifiers": [ [ "species_10605184", "catalyst" ] ], "additional_components": [ "DDB_G0279445" ] }, "reaction_10591393": { "compartment": "compartment_876", "id": "reaction_10591393", "reactome": "R-DDI-425994", "name": "Na+/H+ exchanger transport (at cell membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_74113" ], "products": [ "species_351626", "species_83910" ], "modifiers": [ [ "species_10591390", "catalyst" ] ], "additional_components": [ "Q54TB5", "DDB_G0281877", "Q552S0", "DDB_G0275711" ] }, "reaction_10591341": { "compartment": "compartment_172574", "id": "reaction_10591341", "reactome": "R-DDI-425965", "name": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425999", "species_83910" ], "products": [ "species_425977", "species_70106" ], "modifiers": [ [ "species_10591338", "catalyst" ] ], "additional_components": [ "Q54TB5", "DDB_G0281877", "Q552S0", "DDB_G0275711" ] }, "reaction_10591358": { "compartment": "compartment_171062", "id": "reaction_10591358", "reactome": "R-DDI-425983", "name": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425978", "species_83910" ], "products": [ "species_70106", "species_425971" ], "modifiers": [ [ "species_10591355", "catalyst" ] ], "additional_components": [ "Q552S0", "DDB_G0275711", "Q54TB5", "DDB_G0281877" ] }, "reaction_10591406": { "compartment": "compartment_20699", "id": "reaction_10591406", "reactome": "R-DDI-426015", "name": "Na+/H+ exchanger transport (at trans-golgi membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425969", "species_83910" ], "products": [ "species_70106", "species_425958" ], "modifiers": [ [ "species_10591403", "catalyst" ] ], "additional_components": [ "Q54TB5", "DDB_G0281877", "Q552S0", "DDB_G0275711" ] }, "reaction_10591664": { "compartment": "compartment_876", "id": "reaction_10591664", "reactome": "R-DDI-428609", "name": "Type I Na+-coupled phosphate co-transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109277", "species_74113" ], "products": [ "species_29372", "species_83910" ], "modifiers": [ [ "species_10591661", "catalyst" ] ], "additional_components": [ "Q54UX4", "DDB_G0280761", "Q54W37", "DDB_G0280761" ] }, "reaction_10622115": { "compartment": "compartment_70101", "id": "reaction_10622115", "reactome": "R-DDI-8875623", "name": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_70106" ], "products": [ "species_113529", "species_113552" ], "modifiers": [ [ "species_10622110", "catalyst" ] ], "additional_components": [ "DDB_G0283329" ] }, "reaction_10591574": { "compartment": "compartment_201753", "id": "reaction_10591574", "reactome": "R-DDI-428052", "name": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_428548" ], "products": [ "species_70106", "species_428614" ], "modifiers": [ [ "species_10591571", "catalyst" ] ], "additional_components": [ "Q54UX4", "DDB_G0280761", "Q54W37", "DDB_G0280761" ] }, "reaction_10593024": { "compartment": "compartment_70101", "id": "reaction_10593024", "reactome": "R-DDI-450095", "name": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10586023", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10624195": { "compartment": "compartment_70101", "id": "reaction_10624195", "reactome": "R-DDI-8981570", "name": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10624192", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10591744": { "compartment": "compartment_876", "id": "reaction_10591744", "reactome": "R-DDI-428779", "name": "GLUT7 and GLUT11 transport glucose and fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428819" ], "products": [ "species_428802" ], "modifiers": [ [ "species_10591741", "catalyst" ] ], "additional_components": [ "species_70113", "species_29532", "species_70113", "species_29532", "Q54Z55", "DDB_G0277773", "Q54CM5", "DDB_G0292814" ] }, "reaction_10591780": { "compartment": "compartment_876", "id": "reaction_10591780", "reactome": "R-DDI-429094", "name": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10591777", "catalyst" ] ], "additional_components": [ "Q54M69", "DDB_G0286151", "Q54UC8", "DDB_G0281155" ] }, "reaction_10624197": { "compartment": "compartment_70101", "id": "reaction_10624197", "reactome": "R-DDI-8981574", "name": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10586023", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10605166": { "compartment": "compartment_70101", "id": "reaction_10605166", "reactome": "R-DDI-5339524", "name": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10593015", "catalyst" ], [ "species_113592", "inhibitor" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10591761": { "compartment": "compartment_876", "id": "reaction_10591761", "reactome": "R-DDI-429036", "name": "SLC2A9 transports Fru, Glc, urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429078" ], "products": [ "species_429148" ], "modifiers": [ [ "species_10591758", "catalyst" ] ], "additional_components": [ "species_70113", "species_30034", "species_29532", "species_70113", "species_30034", "species_29532", "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10624179": { "compartment": "compartment_70101", "id": "reaction_10624179", "reactome": "R-DDI-8981553", "name": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10624176", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10593019": { "compartment": "compartment_70101", "id": "reaction_10593019", "reactome": "R-DDI-450088", "name": "GLUT1 tetramer binds 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10593015" ], "products": [ "species_10593017" ], "modifiers": [], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773", "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773", "species_113592" ] }, "reaction_10624184": { "compartment": "compartment_70101", "id": "reaction_10624184", "reactome": "R-DDI-8981564", "name": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10624181", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814" ] }, "reaction_10622136": { "compartment": "compartment_70101", "id": "reaction_10622136", "reactome": "R-DDI-8875902", "name": "SLC45A3 transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10622133", "catalyst" ] ], "additional_components": [ "DDB_G0276801" ] }, "reaction_10593021": { "compartment": "compartment_70101", "id": "reaction_10593021", "reactome": "R-DDI-450092", "name": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593017" ], "products": [ "species_113592", "species_10593015" ], "modifiers": [], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773", "species_113592", "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10622268": { "compartment": "compartment_70101", "id": "reaction_10622268", "reactome": "R-DDI-8876319", "name": "SLC50A1 transports Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10622265", "catalyst" ] ], "additional_components": [ "DDB_G0287763" ] }, "reaction_10623330": { "compartment": "compartment_13231", "id": "reaction_10623330", "reactome": "R-DDI-8944457", "name": "MAF1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623321" ], "products": [ "species_10623319" ], "modifiers": [ [ "species_10584242", "inhibitor" ] ], "additional_components": [ "DDB_G0278673", "DDB_G0278673", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318" ] }, "reaction_10623328": { "compartment": "compartment_70101", "id": "reaction_10623328", "reactome": "R-DDI-8944454", "name": "mTORC1 phosphorylates MAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623321", "species_113592" ], "products": [ "species_10623326", "species_29370" ], "modifiers": [ [ "species_10584242", "catalyst" ] ], "additional_components": [ "DDB_G0278673", "DDB_G0278673", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318" ] }, "reaction_10616691": { "compartment": "compartment_70101", "id": "reaction_10616691", "reactome": "R-DDI-6807105", "name": "Monoubiquitinated PTEN translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616685" ], "products": [ "species_10616689" ], "modifiers": [], "additional_components": [ "DDB_G0286557", "DDB_G0286557" ] }, "reaction_10616696": { "compartment": "compartment_7660", "id": "reaction_10616696", "reactome": "R-DDI-6807118", "name": "USP7 deubiquitinates monoubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10616689" ], "products": [ "species_10616693", "species_10576865" ], "modifiers": [ [ "species_10602170", "catalyst" ], [ "species_10601869", "inhibitor" ] ], "additional_components": [ "DDB_G0286557", "DDB_G0286557", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0276443", "DDB_G0285989" ] }, "reaction_10616699": { "compartment": "compartment_7660", "id": "reaction_10616699", "reactome": "R-DDI-6807126", "name": "Deubiquitinated PTEN translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616693" ], "products": [ "species_10587224" ], "modifiers": [], "additional_components": [ "DDB_G0286557", "DDB_G0286557" ] }, "reaction_10618691": { "compartment": "compartment_70101", "id": "reaction_10618691", "reactome": "R-DDI-8850992", "name": "Proteasome degrades polyubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618689" ], "products": [ "species_10577037" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q8T9S7", "DDB_G0286557", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10623382": { "compartment": "compartment_70101", "id": "reaction_10623382", "reactome": "R-DDI-8948800", "name": "TNKS and TNKS2 PARylate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587224", "species_29360" ], "products": [ "species_197277", "species_10623370" ], "modifiers": [ [ "species_10623379", "catalyst" ] ], "additional_components": [ "DDB_G0286557", "DDB_G0286557", "Q86J21", "DDB_G0274293" ] }, "reaction_10618679": { "compartment": "compartment_70101", "id": "reaction_10618679", "reactome": "R-DDI-8850945", "name": "Casein kinase II phosphorylates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10587224" ], "products": [ "species_29370", "species_10618677" ], "modifiers": [ [ "species_10601344", "catalyst" ] ], "additional_components": [ "DDB_G0286557", "DDB_G0286557", "Q54PF1", "DDB_G0284601", "Q02720", "DDB_G0276885", "Q54LR6", "DDB_G0286481" ] }, "reaction_10623365": { "compartment": "compartment_70101", "id": "reaction_10623365", "reactome": "R-DDI-8948757", "name": "AKT phosphorylates MKRN1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10596354" ], "products": [ "species_29370", "species_10623363" ], "modifiers": [ [ "species_10586959", "catalyst" ] ], "additional_components": [ "DDB_G0281657", "DDB_G0281657", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795" ] }, "reaction_10616726": { "compartment": "compartment_70101", "id": "reaction_10616726", "reactome": "R-DDI-6807206", "name": "USP13 and OTUD3 deubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616716", "species_29356" ], "products": [ "species_10577037", "species_10587224" ], "modifiers": [ [ "species_10616723", "catalyst" ] ], "additional_components": [ "DDB_G0286557", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0286557", "Q55FY4", "DDB_G0267906", "P54201", "DDB_G0291239" ] }, "reaction_10616713": { "compartment": "compartment_70101", "id": "reaction_10616713", "reactome": "R-DDI-6807134", "name": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10587224" ], "products": [ "species_10616702" ], "modifiers": [ [ "species_10616710", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0286557", "DDB_G0286557", "C7G034", "DDB_G0285063", "Q54QF1", "DDB_G0283983" ] }, "reaction_10623368": { "compartment": "compartment_70101", "id": "reaction_10623368", "reactome": "R-DDI-8948775", "name": "MKRN1 polyubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10587224" ], "products": [ "species_10616716" ], "modifiers": [ [ "species_10623363", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0286557", "DDB_G0286557", "DDB_G0281657" ] }, "reaction_10593296": { "compartment": "compartment_70101", "id": "reaction_10593296", "reactome": "R-DDI-450488", "name": "BRF1 Complex recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593226", "species_10591881", "species_10591977", "species_10593284", "species_10591874" ], "products": [ "species_10593294" ], "modifiers": [], "additional_components": [ "DDB_G0289921", "DDB_G0283315", "Q55BJ2", "DDB_G0271100", "Q54VM4", "DDB_G0280251", "Q54CU6", "DDB_G0292692", "Q55BB0", "DDB_G0271396", "Q54EU6", "DDB_G0291328", "Q54Q83", "DDB_G0284053", "Q54EV5", "DDB_G0291310", "Q54N99", "DDB_G0285377", "Q54BH9", "DDB_G0293614", "Q7KWX9", "DDB_G0276783", "Q54MG5", "DDB_G0285973", "DDB_G0287243", "Q54KM1", "DDB_G0287243", "Q54MG5", "DDB_G0285973", "Q55BJ2", "DDB_G0271100", "Q54VM4", "DDB_G0280251", "Q54CU6", "DDB_G0292692", "Q55BB0", "DDB_G0271396", "Q54EU6", "DDB_G0291328", "Q54Q83", "DDB_G0284053", "Q54EV5", "DDB_G0291310", "Q54N99", "DDB_G0285377", "Q54BH9", "DDB_G0293614", "Q7KWX9", "DDB_G0276783", "Q54R87", "DDB_G0283315", "Q54GU2", "DDB_G0289921" ] }, "reaction_10593303": { "compartment": "compartment_70101", "id": "reaction_10593303", "reactome": "R-DDI-450490", "name": "Protein Kinase B/Akt phosphorylates BRF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10593284" ], "products": [ "species_29370", "species_10593300" ], "modifiers": [ [ "species_10586949", "catalyst" ] ], "additional_components": [ "Q54MG5", "DDB_G0285973", "Q54MG5", "DDB_G0285973", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795" ] }, "reaction_10593305": { "compartment": "compartment_70101", "id": "reaction_10593305", "reactome": "R-DDI-450517", "name": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_450523", "species_10593282" ], "products": [ "species_10593284" ], "modifiers": [], "additional_components": [ "DDB_G0285973", "Q54MG5", "DDB_G0285973" ] }, "reaction_10586026": { "compartment": "compartment_876", "id": "reaction_10586026", "reactome": "R-DDI-189242", "name": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189246" ], "products": [ "species_189219" ], "modifiers": [ [ "species_10586023", "catalyst" ] ], "additional_components": [ "species_70113", "CHEBI:17118", "species_29532", "CHEBI:17118", "species_70113", "species_29532", "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10586015": { "compartment": "compartment_876", "id": "reaction_10586015", "reactome": "R-DDI-189222", "name": "SLC2A5 transports fructose from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189049" ], "products": [ "species_29532" ], "modifiers": [ [ "species_10586012", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10627366": { "compartment": "compartment_70101", "id": "reaction_10627366", "reactome": "R-DDI-9687625", "name": "ATP binds MLKL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10604755" ], "products": [ "species_10627364" ], "modifiers": [], "additional_components": [ "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54TM7", "DDB_G0281557", "species_113592", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417" ] }, "reaction_10627370": { "compartment": "compartment_70101", "id": "reaction_10627370", "reactome": "R-DDI-9687638", "name": "MLKL binds IP4, IP5 and IP6 ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994146", "species_10604761", "species_1629770", "species_994141" ], "products": [ "species_10627368" ], "modifiers": [], "additional_components": [ "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "species_994141", "species_1629770", "species_994146" ] }, "reaction_10611280": { "compartment": "compartment_70101", "id": "reaction_10611280", "reactome": "R-DDI-5692462", "name": "ATP13A1 transports Mn2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29418", "species_113592" ], "products": [ "species_29372", "species_29370", "species_1981162" ], "modifiers": [ [ "species_10611277", "catalyst" ] ], "additional_components": [ "DDB_G0293004" ] }, "reaction_10595064": { "compartment": "compartment_20699", "id": "reaction_10595064", "reactome": "R-DDI-936895", "name": "ATP7B transports cytosolic Cu2+ to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_209799" ], "products": [ "species_29372", "species_936901", "species_29370" ], "modifiers": [ [ "species_10595061", "catalyst" ] ], "additional_components": [ "Q55DN5", "DDB_G0284141", "Q54Q77", "DDB_G0284141", "Q557B5", "DDB_G0284141" ] }, "reaction_10595352": { "compartment": "compartment_70101", "id": "reaction_10595352", "reactome": "R-DDI-947591", "name": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_947588", "species_113592" ], "products": [ "species_29372", "species_29370", "species_947594" ], "modifiers": [ [ "species_10595291", "catalyst" ] ], "additional_components": [ "species_1500646", "species_1500581", "species_1500581", "species_1500646", "Q54U08", "DDB_G0281401", "Q86H52", "DDB_G0286891", "Q551T0", "DDB_G0286891", "Q553A4", "DDB_G0286891", "Q54L55", "DDB_G0286891", "Q55E61", "DDB_G0286891" ] }, "reaction_10611291": { "compartment": "compartment_70101", "id": "reaction_10611291", "reactome": "R-DDI-5692480", "name": "ATP13A2 transports cations from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5692450" ], "products": [ "species_29372", "species_29370", "species_5692484" ], "modifiers": [ [ "species_10611288", "catalyst" ] ], "additional_components": [ "Q54NW5", "DDB_G0284955", "Q54P22", "DDB_G0284955", "Q54X63", "DDB_G0284955" ] }, "reaction_10605018": { "compartment": "compartment_70101", "id": "reaction_10605018", "reactome": "R-DDI-5251989", "name": "ATP13A4,5 transport divalent ions from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5252122", "species_113592" ], "products": [ "species_29372", "species_29370", "species_5252016" ], "modifiers": [ [ "species_10605015", "catalyst" ] ], "additional_components": [ "Q54P22", "DDB_G0284955", "Q54X63", "DDB_G0284955", "Q54NW5", "DDB_G0284955" ] }, "reaction_10600371": { "compartment": "compartment_161320", "id": "reaction_10600371", "reactome": "R-DDI-2130706", "name": "MHC class II antigen processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2213225" ], "products": [ "species_2213226" ], "modifiers": [ [ "species_10600368", "catalyst" ] ], "additional_components": [ "O76856", "DDB_G0279411", "Q54UH2", "DDB_G0282991", "Q23894", "DDB_G0283867", "Q54RQ2", "DDB_G0282991", "Q54UH3", "DDB_G0282991", "Q86KD4", "DDB_G0282991", "P04989", "DDB_G0279799", "Q54TR1", "DDB_G0281605", "P04988", "DDB_G0290957" ] }, "reaction_10605435": { "compartment": "compartment_70101", "id": "reaction_10605435", "reactome": "R-DDI-5578910", "name": "KCNK dimers transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10605432", "catalyst" ] ], "additional_components": [ "Q86K40", "DDB_G0277255", "Q8T268", "DDB_G0277255" ] }, "reaction_10612564": { "compartment": "compartment_1660541", "id": "reaction_10612564", "reactome": "R-DDI-6784729", "name": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612534" ], "products": [ "species_10612562" ], "modifiers": [], "additional_components": [ "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54H39", "DDB_G0289721", "Q54X82", "DDB_G0279141", "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54X82", "DDB_G0279141", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403" ] }, "reaction_10622308": { "compartment": "compartment_161320", "id": "reaction_10622308", "reactome": "R-DDI-8876472", "name": "NPC2 binds CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848047", "species_10622304" ], "products": [ "species_10622306" ], "modifiers": [], "additional_components": [ "Q54SW1", "DDB_G0287185", "Q54MV4", "DDB_G0287185", "Q54SZ8", "DDB_G0287185", "Q54SW2", "DDB_G0287185", "Q54TL9", "DDB_G0287185", "Q54SZ9", "DDB_G0287185", "Q54KP7", "DDB_G0287185", "Q55BL4", "DDB_G0287185", "Q54YD2", "DDB_G0287185", "Q54SW1", "DDB_G0287185", "Q54MV4", "DDB_G0287185", "Q54SZ8", "DDB_G0287185", "Q54SW2", "DDB_G0287185", "Q54TL9", "DDB_G0287185", "Q54SZ9", "DDB_G0287185", "Q54KP7", "DDB_G0287185", "Q55BL4", "DDB_G0287185", "Q54YD2", "DDB_G0287185", "species_216762" ] }, "reaction_10612566": { "compartment": "compartment_1660541", "id": "reaction_10612566", "reactome": "R-DDI-6784738", "name": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612562" ], "products": [ "species_10612560" ], "modifiers": [], "additional_components": [ "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54X82", "DDB_G0279141", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54X82", "DDB_G0279141", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403" ] }, "reaction_10622314": { "compartment": "compartment_161320", "id": "reaction_10622314", "reactome": "R-DDI-8876484", "name": "NPC2 transfers CHOL to NPC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622310", "species_10622306" ], "products": [ "species_10622312", "species_10622304" ], "modifiers": [], "additional_components": [ "DDB_G0269158", "Q54SW1", "DDB_G0287185", "Q54MV4", "DDB_G0287185", "Q54SZ8", "DDB_G0287185", "Q54SW2", "DDB_G0287185", "Q54TL9", "DDB_G0287185", "Q54SZ9", "DDB_G0287185", "Q54KP7", "DDB_G0287185", "Q55BL4", "DDB_G0287185", "Q54YD2", "DDB_G0287185", "species_216762", "Q9TVK6", "DDB_G0269158", "species_216762", "Q54SW1", "DDB_G0287185", "Q54MV4", "DDB_G0287185", "Q54SZ8", "DDB_G0287185", "Q54SW2", "DDB_G0287185", "Q54TL9", "DDB_G0287185", "Q54SZ9", "DDB_G0287185", "Q54KP7", "DDB_G0287185", "Q55BL4", "DDB_G0287185", "Q54YD2", "DDB_G0287185" ] }, "reaction_10617819": { "compartment": "compartment_70101", "id": "reaction_10617819", "reactome": "R-DDI-6813720", "name": "NCEH1 hydrolyzes cholesterol esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_163579" ], "products": [ "species_8876730", "species_216762" ], "modifiers": [ [ "species_10617816", "catalyst" ] ], "additional_components": [ "DDB_G0283819" ] }, "reaction_10622316": { "compartment": "compartment_12045", "id": "reaction_10622316", "reactome": "R-DDI-8876485", "name": "CHOL translocates from lysosome membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622312" ], "products": [ "species_193384", "species_10622310" ], "modifiers": [], "additional_components": [ "Q9TVK6", "DDB_G0269158", "species_216762", "DDB_G0269158" ] }, "reaction_10622364": { "compartment": "compartment_12045", "id": "reaction_10622364", "reactome": "R-DDI-8876696", "name": "SOAT1,2 transfer acyl group to CHOL forming CHEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193384", "species_1500578" ], "products": [ "species_8876704", "species_76194" ], "modifiers": [ [ "species_10622361", "catalyst" ] ], "additional_components": [ "Q551G5", "DDB_G0276523" ] }, "reaction_10619494": { "compartment": "compartment_876", "id": "reaction_10619494", "reactome": "R-DDI-8855130", "name": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619484" ], "products": [ "species_10619492" ], "modifiers": [], "additional_components": [ "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54H39", "DDB_G0289721", "Q54X82", "DDB_G0279141", "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54X82", "DDB_G0279141", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403" ] }, "reaction_10607943": { "compartment": "compartment_70101", "id": "reaction_10607943", "reactome": "R-DDI-5682101", "name": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607908" ], "products": [ "species_29370", "species_10607940" ], "modifiers": [ [ "species_10582991", "catalyst" ] ], "additional_components": [ "Q8T6J5", "DDB_G0267438", "Q54BT5", "DDB_G0293436", "Q555Z5", "DDB_G0274121", "Q55BC0", "DDB_G0271138", "Q8T5Z7", "DDB_G0291994", "Q8T6J1", "DDB_G0291245", "Q8T6J2", "DDB_G0274119", "Q55BC0", "DDB_G0271138", "Q8T6J5", "DDB_G0267438", "Q8T5Z7", "DDB_G0291994", "Q54BT5", "DDB_G0293436", "Q8T6J1", "DDB_G0291245", "Q555Z5", "DDB_G0274121", "Q8T6J2", "DDB_G0274119", "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029" ] }, "reaction_10607945": { "compartment": "compartment_12045", "id": "reaction_10607945", "reactome": "R-DDI-5682103", "name": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607890" ], "products": [ "species_10607908" ], "modifiers": [], "additional_components": [ "Q555Z5", "DDB_G0274121", "Q8T6J1", "DDB_G0291245", "Q55BC0", "DDB_G0271138", "Q8T6J2", "DDB_G0274119", "Q54BT5", "DDB_G0293436", "Q8T5Z7", "DDB_G0291994", "Q8T6J5", "DDB_G0267438", "Q8T6J5", "DDB_G0267438", "Q54BT5", "DDB_G0293436", "Q555Z5", "DDB_G0274121", "Q55BC0", "DDB_G0271138", "Q8T5Z7", "DDB_G0291994", "Q8T6J1", "DDB_G0291245", "Q8T6J2", "DDB_G0274119" ] }, "reaction_10620000": { "compartment": "compartment_70616", "id": "reaction_10620000", "reactome": "R-DDI-8867344", "name": "OMA1 hydrolyses OPA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619980", "species_113521" ], "products": [ "species_10619992", "species_10619986" ], "modifiers": [ [ "species_10619997", "catalyst" ] ], "additional_components": [ "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "DDB_G0289335" ] }, "reaction_10604720": { "compartment": "compartment_70101", "id": "reaction_10604720", "reactome": "R-DDI-5213464", "name": "RIPK1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10604713" ], "products": [ "species_10604715", "species_29370" ], "modifiers": [ [ "species_10604713", "catalyst" ], [ "species_10604718", "inhibitor" ] ], "additional_components": [ "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417" ] }, "reaction_10604723": { "compartment": "compartment_70101", "id": "reaction_10604723", "reactome": "R-DDI-5213466", "name": "RIPK3 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604715", "species_113592" ], "products": [ "species_10602348", "species_29370" ], "modifiers": [ [ "species_10604713", "catalyst" ], [ "species_10604718", "inhibitor" ] ], "additional_components": [ "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417" ] }, "reaction_10604757": { "compartment": "compartment_70101", "id": "reaction_10604757", "reactome": "R-DDI-5218891", "name": "RIPK1:RIPK3 oligomer binds MLKL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602350", "species_10604753" ], "products": [ "species_10604755" ], "modifiers": [], "additional_components": [ "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "DDB_G0281557", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417" ] }, "reaction_10604759": { "compartment": "compartment_70101", "id": "reaction_10604759", "reactome": "R-DDI-5218905", "name": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602348" ], "products": [ "species_10602350" ], "modifiers": [], "additional_components": [ "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417" ] }, "reaction_10605782": { "compartment": "compartment_876", "id": "reaction_10605782", "reactome": "R-DDI-5620975", "name": "MLKL binds PIPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5620974", "species_10602358" ], "products": [ "species_10605771" ], "modifiers": [ [ "species_10605780", "inhibitor" ] ], "additional_components": [ "species_179838", "species_1806180", "species_179856", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "species_179838", "species_1806180", "species_179856", "Q8T7K0", "DDB_G0275451", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417" ] }, "reaction_10604764": { "compartment": "compartment_70101", "id": "reaction_10604764", "reactome": "R-DDI-5218906", "name": "RIPK3 phosphorylates MLKL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10604755" ], "products": [ "species_29370", "species_10604761" ], "modifiers": [ [ "species_10604755", "catalyst" ] ], "additional_components": [ "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417" ] }, "reaction_10600860": { "compartment": "compartment_70101", "id": "reaction_10600860", "reactome": "R-DDI-2317332", "name": "PIP3 recruits AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10590487" ], "products": [ "species_10587009" ], "modifiers": [], "additional_components": [ "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_179838", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795" ] }, "reaction_10625796": { "compartment": "compartment_17951", "id": "reaction_10625796", "reactome": "R-DDI-9033520", "name": "TYSND1 cleaves TYSND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_10625726" ], "products": [ "species_10625791", "species_10625793" ], "modifiers": [ [ "species_10625726", "catalyst" ] ], "additional_components": [ "DDB_G0279049", "DDB_G0279049", "DDB_G0279049", "DDB_G0279049" ] }, "reaction_10589960": { "compartment": "compartment_70101", "id": "reaction_10589960", "reactome": "R-DDI-380930", "name": "Phosphorylated AMPK binds AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587326", "species_76577" ], "products": [ "species_10589958" ], "modifiers": [], "additional_components": [ "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643" ] }, "reaction_10592925": { "compartment": "compartment_876", "id": "reaction_10592925", "reactome": "R-DDI-447074", "name": "AMPK phosphorylates Raptor in the mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10584242" ], "products": [ "species_29370", "species_10584309" ], "modifiers": [ [ "species_10589958", "catalyst" ] ], "additional_components": [ "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643" ] }, "reaction_10606321": { "compartment": "compartment_70101", "id": "reaction_10606321", "reactome": "R-DDI-5653957", "name": "Rag dimer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584219", "species_10584232" ], "products": [ "species_10584234" ], "modifiers": [], "additional_components": [ "Q54IK1", "DDB_G0288701", "species_29438", "Q54PK6", "DDB_G0284495", "species_29420", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438" ] }, "reaction_10623826": { "compartment": "compartment_70101", "id": "reaction_10623826", "reactome": "R-DDI-8952726", "name": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428011" ], "products": [ "species_29468" ], "modifiers": [ [ "species_10584238", "catalyst" ] ], "additional_components": [ "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567" ] }, "reaction_10584160": { "compartment": "compartment_17938", "id": "reaction_10584160", "reactome": "R-DDI-165195", "name": "GTP loading by Rheb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10584156" ], "products": [ "species_10584158", "species_29420" ], "modifiers": [], "additional_components": [ "Q54DD9", "DDB_G0292318", "species_29420", "Q54DD9", "DDB_G0292318", "species_29438" ] }, "reaction_10606323": { "compartment": "compartment_17938", "id": "reaction_10606323", "reactome": "R-DDI-5653968", "name": "Ragulator:Rag dimers:SLC38A9 bind mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584238", "species_10584177" ], "products": [ "species_10584240" ], "modifiers": [], "additional_components": [ "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567" ] }, "reaction_10589778": { "compartment": "compartment_17938", "id": "reaction_10589778", "reactome": "R-DDI-377186", "name": "Activated Akt1 phosphorylates AKT1S1 (PRAS40)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10584263" ], "products": [ "species_10584255", "species_29370" ], "modifiers": [ [ "species_10587569", "catalyst" ] ], "additional_components": [ "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795" ] }, "reaction_10606325": { "compartment": "compartment_70101", "id": "reaction_10606325", "reactome": "R-DDI-5653974", "name": "Ragulator binds Rag dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584206", "species_10584234" ], "products": [ "species_10584236" ], "modifiers": [], "additional_components": [ "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567" ] }, "reaction_10584244": { "compartment": "compartment_70101", "id": "reaction_10584244", "reactome": "R-DDI-165680", "name": "Formation of active mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584158", "species_10584240" ], "products": [ "species_10584242" ], "modifiers": [], "additional_components": [ "Q54DD9", "DDB_G0292318", "species_29438", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318" ] }, "reaction_10584272": { "compartment": "compartment_17938", "id": "reaction_10584272", "reactome": "R-DDI-165692", "name": "Phosphorylation of 4E-BP1 by activated mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580061", "species_113592" ], "products": [ "species_10584250", "species_29370" ], "modifiers": [ [ "species_10584242", "catalyst" ], [ "species_10584259", "catalyst" ], [ "species_10584263", "inhibitor" ], [ "species_10584270", "inhibitor" ] ], "additional_components": [ "Q55FE0", "DDB_G0268574", "Q54DU8", "DDB_G0291990", "Q55FE0", "DDB_G0268574", "Q54DU8", "DDB_G0291990", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54UR2", "DDB_G0280877" ] }, "reaction_10584339": { "compartment": "compartment_70101", "id": "reaction_10584339", "reactome": "R-DDI-165766", "name": "Phosphorylation and activation of eIF4G by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580029", "species_113592" ], "products": [ "species_29370", "species_10584337" ], "modifiers": [ [ "species_10584299", "catalyst" ] ], "additional_components": [ "DDB_G0275395", "DDB_G0275395", "P34102", "DDB_G0286125", "Q8MYF1", "DDB_G0277449" ] }, "reaction_10627344": { "compartment": "compartment_70101", "id": "reaction_10627344", "reactome": "R-DDI-9679044", "name": "FKBP1A binds sirolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584268", "species_9678687" ], "products": [ "species_10584270" ], "modifiers": [], "additional_components": [ "DDB_G0280877", "Q54UR2", "DDB_G0280877" ] }, "reaction_10584322": { "compartment": "compartment_70101", "id": "reaction_10584322", "reactome": "R-DDI-165726", "name": "Phosphorylation of Ribosomal protein S6 by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10579877" ], "products": [ "species_10584319", "species_29370" ], "modifiers": [ [ "species_10584299", "catalyst" ] ], "additional_components": [ "DDB_G0280823", "DDB_G0280823", "P34102", "DDB_G0286125", "Q8MYF1", "DDB_G0277449" ] }, "reaction_10584277": { "compartment": "compartment_70101", "id": "reaction_10584277", "reactome": "R-DDI-165708", "name": "Dissociation of phosphorylated 4EBP1 from eIF4E", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584250" ], "products": [ "species_10584248", "species_10580024" ], "modifiers": [], "additional_components": [ "Q55FE0", "DDB_G0268574", "Q54DU8", "DDB_G0291990", "DDB_G0291990", "DDB_G0268574" ] }, "reaction_10584311": { "compartment": "compartment_17938", "id": "reaction_10584311", "reactome": "R-DDI-165718", "name": "mTORC1 phosphorylation of RPS6KB1 (S6K)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10584289" ], "products": [ "species_10584299", "species_29370" ], "modifiers": [ [ "species_10584242", "catalyst" ], [ "species_10584259", "catalyst" ], [ "species_10584309", "inhibitor" ], [ "species_10584270", "inhibitor" ] ], "additional_components": [ "P34102", "DDB_G0286125", "Q8MYF1", "DDB_G0277449", "P34102", "DDB_G0286125", "Q8MYF1", "DDB_G0277449", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54UR2", "DDB_G0280877" ] }, "reaction_10584344": { "compartment": "compartment_70101", "id": "reaction_10584344", "reactome": "R-DDI-165777", "name": "Phosphorylation and activation of eIF4B by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10580036" ], "products": [ "species_29370", "species_10584342" ], "modifiers": [ [ "species_10584299", "catalyst" ] ], "additional_components": [ "DDB_G0275459", "DDB_G0275459", "P34102", "DDB_G0286125", "Q8MYF1", "DDB_G0277449" ] }, "reaction_10584332": { "compartment": "compartment_70101", "id": "reaction_10584332", "reactome": "R-DDI-165758", "name": "Phosphorylation and inactivation of eEF2K by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10584327" ], "products": [ "species_10584330", "species_29370" ], "modifiers": [ [ "species_10584299", "catalyst" ] ], "additional_components": [ "DDB_G0282489", "DDB_G0282489", "P34102", "DDB_G0286125", "Q8MYF1", "DDB_G0277449" ] }, "reaction_10606859": { "compartment": "compartment_17938", "id": "reaction_10606859", "reactome": "R-DDI-5672828", "name": "mTORC1 phosphorylates AKT1S1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10584259" ], "products": [ "species_29370", "species_10606856" ], "modifiers": [ [ "species_10584259", "catalyst" ] ], "additional_components": [ "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318" ] }, "reaction_10606319": { "compartment": "compartment_17938", "id": "reaction_10606319", "reactome": "R-DDI-5653936", "name": "Formation of Ragulator complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584204", "species_10584189", "species_10584184", "species_10584199", "species_10584194" ], "products": [ "species_10584206" ], "modifiers": [], "additional_components": [ "DDB_G0283567", "DDB_G0291091", "DDB_G0292160", "DDB_G0291948", "DDB_G0274833", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567" ] }, "reaction_10605537": { "compartment": "compartment_70101", "id": "reaction_10605537", "reactome": "R-DDI-5615668", "name": "AKR1C3 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_975622", "species_29364" ], "products": [ "species_29366", "species_975599" ], "modifiers": [ [ "species_10586594", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10605363": { "compartment": "compartment_70101", "id": "reaction_10605363", "reactome": "R-DDI-5362564", "name": "ADH1A,1C,4 oxidise atROL to atRAL in vitro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975599", "species_29360" ], "products": [ "species_70106", "species_975622", "species_73473" ], "modifiers": [ [ "species_10605360", "catalyst" ] ], "additional_components": [ "species_29426", "Q54TC2", "DDB_G0281865" ] }, "reaction_10611912": { "compartment": "compartment_70101", "id": "reaction_10611912", "reactome": "R-DDI-5696101", "name": "ALDH8A1 oxidises 9cRAL to 9cRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5362565", "species_29360" ], "products": [ "species_70106", "species_5362520", "species_73473" ], "modifiers": [ [ "species_10611909", "catalyst" ] ], "additional_components": [ "DDB_G0283943" ] }, "reaction_10605371": { "compartment": "compartment_70101", "id": "reaction_10605371", "reactome": "R-DDI-5419165", "name": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_975622", "species_29364" ], "products": [ "species_29366", "species_975599" ], "modifiers": [ [ "species_10605368", "catalyst" ] ], "additional_components": [ "DDB_G0293604" ] }, "reaction_10605791": { "compartment": "compartment_70616", "id": "reaction_10605791", "reactome": "R-DDI-5623643", "name": "RDH13 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5623644", "species_5623648", "species_163953" ], "products": [ "species_5623650", "species_5623649" ], "modifiers": [ [ "species_10605788", "catalyst" ] ], "additional_components": [ "DDB_G0286575" ] }, "reaction_10605358": { "compartment": "compartment_70101", "id": "reaction_10605358", "reactome": "R-DDI-5362522", "name": "ALDHs oxidise atRAL to atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_975622", "species_29360" ], "products": [ "species_70106", "species_5334816", "species_73473" ], "modifiers": [ [ "species_10605355", "catalyst" ] ], "additional_components": [ "Q54IU0", "DDB_G0288521" ] }, "reaction_10624618": { "compartment": "compartment_7660", "id": "reaction_10624618", "reactome": "R-DDI-9012319", "name": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10624613" ], "products": [ "species_113582", "species_10624615" ], "modifiers": [ [ "species_10624613", "catalyst" ] ], "additional_components": [ "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "species_1254400", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "species_1254400", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "species_1254400", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10623125": { "compartment": "compartment_7660", "id": "reaction_10623125", "reactome": "R-DDI-8939204", "name": "ESTG binds ESR1:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623113", "species_1254400" ], "products": [ "species_10623115" ], "modifiers": [], "additional_components": [ "Q54WQ9", "DDB_G0279491", "P54651", "DDB_G0267400", "species_113592", "Q55FM3", "DDB_G0268042", "species_1254400", "Q54WQ9", "DDB_G0279491", "P54651", "DDB_G0267400", "species_113592", "Q55FM3", "DDB_G0268042" ] }, "reaction_10627482": { "compartment": "compartment_7660", "id": "reaction_10627482", "reactome": "R-DDI-9709547", "name": "ESTG binds ESR2:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623119", "species_1254400" ], "products": [ "species_10623121" ], "modifiers": [], "additional_components": [ "Q54WQ9", "DDB_G0279491", "P54651", "DDB_G0267400", "species_113592", "Q55FM3", "DDB_G0268042", "species_1254400", "Q54WQ9", "DDB_G0279491", "P54651", "DDB_G0267400", "species_113592", "Q55FM3", "DDB_G0268042" ] }, "reaction_10598291": { "compartment": "compartment_70101", "id": "reaction_10598291", "reactome": "R-DDI-1504190", "name": "DVL is ubiquitinated by CUL3:KLHL12:RBX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598284", "species_10577037" ], "products": [ "species_10598288" ], "modifiers": [ [ "species_10598284", "catalyst" ] ], "additional_components": [ "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903", "Q55BF8", "DDB_G0271372", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903", "Q55BF8", "DDB_G0271372", "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903", "Q55BF8", "DDB_G0271372" ] }, "reaction_10598293": { "compartment": "compartment_70101", "id": "reaction_10598293", "reactome": "R-DDI-1504193", "name": "Ubiquitinated DVL is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598288" ], "products": [ "species_10577037", "species_10598280" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903", "Q55BF8", "DDB_G0271372", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903", "Q55BF8", "DDB_G0271372", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10602277": { "compartment": "compartment_20699", "id": "reaction_10602277", "reactome": "R-DDI-3247836", "name": "Retromer recycles WLS to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602271" ], "products": [ "species_10602275" ], "modifiers": [], "additional_components": [ "Q54C24", "DDB_G0293218", "Q55CA0", "DDB_G0269168", "Q54IF7", "DDB_G0288787", "Q54UN7", "DDB_G0280921", "Q54C24", "DDB_G0293218", "Q55CA0", "DDB_G0269168", "Q54IF7", "DDB_G0288787", "Q54UN7", "DDB_G0280921" ] }, "reaction_10600819": { "compartment": "compartment_70101", "id": "reaction_10600819", "reactome": "R-DDI-2219524", "name": "PDPK1 binds PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587607", "species_179856" ], "products": [ "species_10600817" ], "modifiers": [], "additional_components": [ "DDB_G0281471", "species_179856", "Q54TW2", "DDB_G0281471" ] }, "reaction_10596961": { "compartment": "compartment_70101", "id": "reaction_10596961", "reactome": "R-DDI-1011598", "name": "DOCKs bind to RhoGEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596957", "species_10590248" ], "products": [ "species_10596959" ], "modifiers": [], "additional_components": [ "Q54CA8", "DDB_G0293084", "Q554I8", "DDB_G0293084", "Q55EI2", "DDB_G0293084", "Q86I66", "DDB_G0293084", "Q54PB7", "DDB_G0292004", "Q55BQ8", "DDB_G0292004", "Q54DS6", "DDB_G0291974", "Q54DW1", "DDB_G0292004", "DDB_G0277869", "P34144", "DDB_G0277869", "Q54CA8", "DDB_G0293084", "Q554I8", "DDB_G0293084", "Q55EI2", "DDB_G0293084", "Q86I66", "DDB_G0293084", "Q54PB7", "DDB_G0292004", "Q55BQ8", "DDB_G0292004", "Q54DS6", "DDB_G0291974", "Q54DW1", "DDB_G0292004" ] }, "reaction_10596720": { "compartment": "compartment_70101", "id": "reaction_10596720", "reactome": "R-DDI-984689", "name": "Kinesin-7 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596682" ], "products": [ "species_10596684" ], "modifiers": [], "additional_components": [ "DDB_G0285101", "Q54NP8", "DDB_G0285101" ] }, "reaction_10596718": { "compartment": "compartment_70101", "id": "reaction_10596718", "reactome": "R-DDI-984606", "name": "Kinesin-5 is a homotetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596668" ], "products": [ "species_10596670" ], "modifiers": [], "additional_components": [ "DDB_G0288361", "Q6RZZ9", "DDB_G0288361" ] }, "reaction_10596740": { "compartment": "compartment_7660", "id": "reaction_10596740", "reactome": "R-DDI-994106", "name": "HP1 alpha binds Histone H3K9(me)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596728", "species_10596736" ], "products": [ "species_10596738" ], "modifiers": [], "additional_components": [ "Q54RN0", "DDB_G0283023", "Q54RQ4", "DDB_G0283023", "Q55C69", "DDB_G0270198", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q54RN0", "DDB_G0283023", "Q54RQ4", "DDB_G0283023", "Q55C69", "DDB_G0270198" ] }, "reaction_10596807": { "compartment": "compartment_70101", "id": "reaction_10596807", "reactome": "R-DDI-994148", "name": "LRRC16A binds F-actin capping protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594244", "species_10596803" ], "products": [ "species_10596805" ], "modifiers": [], "additional_components": [ "P13021", "DDB_G0267374", "P13022", "DDB_G0272104", "Q95VZ3", "DDB_G0292386", "Q54LE3", "DDB_G0293920", "Q54SR9", "DDB_G0293920", "Q54B43", "DDB_G0293920", "Q54YK2", "DDB_G0293920", "Q54B76", "DDB_G0293920", "Q54MF0", "DDB_G0293920", "Q54NS2", "DDB_G0293920", "Q7KWW4", "DDB_G0293920", "Q54G18", "DDB_G0290439", "Q95VZ3", "DDB_G0292386", "Q54LE3", "DDB_G0293920", "Q54SR9", "DDB_G0293920", "Q54B43", "DDB_G0293920", "Q54YK2", "DDB_G0293920", "Q54B76", "DDB_G0293920", "Q54MF0", "DDB_G0293920", "Q54NS2", "DDB_G0293920", "Q7KWW4", "DDB_G0293920", "Q54G18", "DDB_G0290439", "P13021", "DDB_G0267374", "P13022", "DDB_G0272104" ] }, "reaction_10600822": { "compartment": "compartment_70101", "id": "reaction_10600822", "reactome": "R-DDI-2267372", "name": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994123" ], "products": [ "species_994146", "species_29370" ], "modifiers": [ [ "species_10596745", "catalyst" ] ], "additional_components": [ "DDB_G0269746" ] }, "reaction_10594246": { "compartment": "compartment_70101", "id": "reaction_10594246", "reactome": "R-DDI-879459", "name": "F-actin capping protein is a heterodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594237", "species_10594242" ], "products": [ "species_10594244" ], "modifiers": [], "additional_components": [ "DDB_G0272104", "DDB_G0267374", "P13021", "DDB_G0267374", "P13022", "DDB_G0272104" ] }, "reaction_10619768": { "compartment": "compartment_70101", "id": "reaction_10619768", "reactome": "R-DDI-8865107", "name": "MICAL1 produces NADP+, H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29364" ], "products": [ "species_29366", "species_29408" ], "modifiers": [ [ "species_10619765", "catalyst" ] ], "additional_components": [ "Q54FV6", "DDB_G0293708", "Q54BL7", "DDB_G0293708", "species_113596" ] }, "reaction_10596826": { "compartment": "compartment_5460", "id": "reaction_10596826", "reactome": "R-DDI-1008248", "name": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159448", "species_113573" ], "products": [ "species_113581", "species_113525" ], "modifiers": [ [ "species_10596823", "catalyst" ] ], "additional_components": [ "DDB_G0292730" ] }, "reaction_10596748": { "compartment": "compartment_70101", "id": "reaction_10596748", "reactome": "R-DDI-994137", "name": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994149", "species_113592" ], "products": [ "species_29370", "species_994141" ], "modifiers": [ [ "species_10596745", "catalyst" ] ], "additional_components": [ "DDB_G0269746" ] }, "reaction_10596751": { "compartment": "compartment_70101", "id": "reaction_10596751", "reactome": "R-DDI-994140", "name": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994123" ], "products": [ "species_29370", "species_994170" ], "modifiers": [ [ "species_10596745", "catalyst" ] ], "additional_components": [ "DDB_G0269746" ] }, "reaction_10587611": { "compartment": "compartment_70101", "id": "reaction_10587611", "reactome": "R-DDI-202164", "name": "Translocation of PDK1 to Plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587607", "species_202277" ], "products": [ "species_10587609" ], "modifiers": [], "additional_components": [ "DDB_G0281471", "species_1806238", "species_179838", "species_1806238", "species_179838", "Q54TW2", "DDB_G0281471" ] }, "reaction_10626100": { "compartment": "compartment_70101", "id": "reaction_10626100", "reactome": "R-DDI-9609921", "name": "SGTA binds Tail-anchored protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626061", "species_10626096" ], "products": [ "species_10626098" ], "modifiers": [], "additional_components": [ "Q54VG4", "DDB_G0280345", "Q553P6", "DDB_G0275381", "Q86L22", "DDB_G0277079", "Q54XT7", "DDB_G0278753", "Q54ZH1", "DDB_G0277565", "Q54HM5", "DDB_G0289379", "Q54DG1", "DDB_G0292270", "Q54YR4", "DDB_G0278117", "Q54LP7", "DDB_G0286511", "Q54XS7", "DDB_G0278773", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54JV6", "DDB_G0287777", "Q553P6", "DDB_G0275381", "Q86L22", "DDB_G0277079", "Q54XT7", "DDB_G0278753", "Q54ZH1", "DDB_G0277565", "Q54HM5", "DDB_G0289379", "Q54DG1", "DDB_G0292270", "Q54YR4", "DDB_G0278117", "Q54LP7", "DDB_G0286511", "Q54XS7", "DDB_G0278773", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54JV6", "DDB_G0287777", "Q54VG4", "DDB_G0280345" ] }, "reaction_10626164": { "compartment": "compartment_70101", "id": "reaction_10626164", "reactome": "R-DDI-9617595", "name": "SGTA binds mislocalized membrane protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626061", "species_10626092" ], "products": [ "species_10626162" ], "modifiers": [], "additional_components": [ "Q54VG4", "DDB_G0280345", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54VG4", "DDB_G0280345" ] }, "reaction_10625730": { "compartment": "compartment_17947", "id": "reaction_10625730", "reactome": "R-DDI-9033235", "name": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625710" ], "products": [ "species_10623900", "species_10625728" ], "modifiers": [], "additional_components": [ "Q556W1", "DDB_G0273291", "Q54E41", "DDB_G0291814", "Q75JR2", "DDB_G0272210", "Q54XC3", "DDB_G0279049", "Q54US8", "DDB_G0280851", "Q54GT6", "DDB_G0289923", "Q54QI7", "DDB_G0283813", "Q54GK8", "DDB_G0290089", "Q54GQ6", "DDB_G0289993", "Q54XZ0", "DDB_G0277911", "Q7KWR0", "DDB_G0276281", "Q8MMS1", "DDB_G0277477", "Q54T91", "DDB_G0281917", "Q5FXM5", "DDB_G0270658", "Q54SS0", "DDB_G0282261", "Q54GC2", "DDB_G0290277", "Q54JQ2", "DDB_G0287851", "Q55CT1", "DDB_G0269912", "O77229", "DDB_G0274595", "Q54FR4", "DDB_G0290631", "Q54DA9", "DDB_G0292402", "Q54MD1", "DDB_G0286033", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54MD1", "DDB_G0286033", "Q54GT6", "DDB_G0289923", "Q5FXM5", "DDB_G0270658", "Q54GQ6", "DDB_G0289993", "Q54DA9", "DDB_G0292402", "Q8MMS1", "DDB_G0277477", "Q54E41", "DDB_G0291814", "Q54GC2", "DDB_G0290277", "Q75JR2", "DDB_G0272210", "Q54US8", "DDB_G0280851", "Q54T91", "DDB_G0281917", "Q54SS0", "DDB_G0282261", "O77229", "DDB_G0274595", "Q7KWR0", "DDB_G0276281", "Q54QI7", "DDB_G0283813", "Q55CT1", "DDB_G0269912", "Q556W1", "DDB_G0273291", "Q54JQ2", "DDB_G0287851", "Q54XZ0", "DDB_G0277911", "Q54XC3", "DDB_G0279049", "Q54GK8", "DDB_G0290089", "Q54FR4", "DDB_G0290631" ] }, "reaction_10625798": { "compartment": "compartment_17947", "id": "reaction_10625798", "reactome": "R-DDI-9033527", "name": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623902", "species_10625736" ], "products": [ "species_10625738" ], "modifiers": [], "additional_components": [ "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54WA3", "DDB_G0279801", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54MD1", "DDB_G0286033", "Q54WA3", "DDB_G0279801", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54MD1", "DDB_G0286033", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765" ] }, "reaction_10625732": { "compartment": "compartment_17947", "id": "reaction_10625732", "reactome": "R-DDI-9033236", "name": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625708", "species_10625706" ], "products": [ "species_10625710" ], "modifiers": [], "additional_components": [ "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q556W1", "DDB_G0273291", "Q54E41", "DDB_G0291814", "Q75JR2", "DDB_G0272210", "Q54XC3", "DDB_G0279049", "Q54US8", "DDB_G0280851", "Q54GT6", "DDB_G0289923", "Q54QI7", "DDB_G0283813", "Q54GK8", "DDB_G0290089", "Q54GQ6", "DDB_G0289993", "Q54XZ0", "DDB_G0277911", "Q7KWR0", "DDB_G0276281", "Q8MMS1", "DDB_G0277477", "Q54T91", "DDB_G0281917", "Q5FXM5", "DDB_G0270658", "Q54SS0", "DDB_G0282261", "Q54GC2", "DDB_G0290277", "Q54JQ2", "DDB_G0287851", "Q55CT1", "DDB_G0269912", "O77229", "DDB_G0274595", "Q54FR4", "DDB_G0290631", "Q54DA9", "DDB_G0292402", "Q54MD1", "DDB_G0286033", "Q556W1", "DDB_G0273291", "Q54E41", "DDB_G0291814", "Q75JR2", "DDB_G0272210", "Q54XC3", "DDB_G0279049", "Q54US8", "DDB_G0280851", "Q54GT6", "DDB_G0289923", "Q54QI7", "DDB_G0283813", "Q54GK8", "DDB_G0290089", "Q54GQ6", "DDB_G0289993", "Q54XZ0", "DDB_G0277911", "Q7KWR0", "DDB_G0276281", "Q8MMS1", "DDB_G0277477", "Q54T91", "DDB_G0281917", "Q5FXM5", "DDB_G0270658", "Q54SS0", "DDB_G0282261", "Q54GC2", "DDB_G0290277", "Q54JQ2", "DDB_G0287851", "Q55CT1", "DDB_G0269912", "O77229", "DDB_G0274595", "Q54FR4", "DDB_G0290631", "Q54DA9", "DDB_G0292402", "Q54MD1", "DDB_G0286033", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523" ] }, "reaction_10625643": { "compartment": "compartment_70101", "id": "reaction_10625643", "reactome": "R-DDI-9033232", "name": "PEX7 binds cargo proteins containing PTS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625628", "species_10625639" ], "products": [ "species_10625641" ], "modifiers": [], "additional_components": [ "DDB_G0279801", "O96759", "DDB_G0286183", "Q54SF6", "DDB_G0282495", "Q86IY4", "DDB_G0274339", "O96759", "DDB_G0286183", "Q54SF6", "DDB_G0282495", "Q86IY4", "DDB_G0274339", "Q54WA3", "DDB_G0279801" ] }, "reaction_10625752": { "compartment": "compartment_70101", "id": "reaction_10625752", "reactome": "R-DDI-9033491", "name": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10625749" ], "products": [ "species_10619197", "species_10577037", "species_10625704" ], "modifiers": [ [ "species_10625749", "catalyst" ] ], "additional_components": [ "Q54MD1", "DDB_G0286033", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q553T4", "DDB_G0275415", "DDB_G0275415", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0286033", "Q54MD1", "DDB_G0286033", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q553T4", "DDB_G0275415" ] }, "reaction_10625743": { "compartment": "compartment_17947", "id": "reaction_10625743", "reactome": "R-DDI-9033485", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625738" ], "products": [ "species_10625740", "species_10577361" ], "modifiers": [ [ "species_10625738", "catalyst" ] ], "additional_components": [ "Q54WA3", "DDB_G0279801", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54MD1", "DDB_G0286033", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54WA3", "DDB_G0279801", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54MD1", "DDB_G0286033", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54WA3", "DDB_G0279801", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54MD1", "DDB_G0286033", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765" ] }, "reaction_10625775": { "compartment": "compartment_70101", "id": "reaction_10625775", "reactome": "R-DDI-9033509", "name": "USP9X binds Ub:PEX5L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619197", "species_10625747" ], "products": [ "species_10625749" ], "modifiers": [], "additional_components": [ "DDB_G0275415", "Q54MD1", "DDB_G0286033", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54MD1", "DDB_G0286033", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q553T4", "DDB_G0275415" ] }, "reaction_10625789": { "compartment": "compartment_17947", "id": "reaction_10625789", "reactome": "R-DDI-9033514", "name": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625779" ], "products": [ "species_10625736", "species_10625787" ], "modifiers": [], "additional_components": [ "Q54MD1", "DDB_G0286033", "O96759", "DDB_G0286183", "Q54SF6", "DDB_G0282495", "Q86IY4", "DDB_G0274339", "Q54WA3", "DDB_G0279801", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54WA3", "DDB_G0279801", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54MD1", "DDB_G0286033", "O96759", "DDB_G0286183", "Q86IY4", "DDB_G0274339", "Q54SF6", "DDB_G0282495" ] }, "reaction_10625927": { "compartment": "compartment_17947", "id": "reaction_10625927", "reactome": "R-DDI-9603775", "name": "PEX3:PEX19:class I PMP dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625899" ], "products": [ "species_10625925", "species_10590211", "species_10590227" ], "modifiers": [], "additional_components": [ "Q54U86", "DDB_G0281213", "Q555I0", "DDB_G0274873", "Q54ZX5", "DDB_G0290631", "Q54FR4", "DDB_G0290631", "Q54GD8", "DDB_G0290631", "Q54XX9", "DDB_G0290631", "Q8T8P3", "DDB_G0293194", "Q54N40", "DDB_G0285523", "Q55FL0", "DDB_G0268564", "Q54VX0", "DDB_G0280367", "Q86AC7", "DDB_G0276913", "Q54H86", "DDB_G0289623", "Q54DG1", "DDB_G0292270", "Q54C55", "DDB_G0293264", "Q54CL3", "DDB_G0292870", "Q76P23", "DDB_G0272346", "Q1ZXK7", "DDB_G0276169", "Q550G0", "DDB_G0277113", "Q86AC7", "DDB_G0276913", "Q54H86", "DDB_G0289623", "Q8T8P3", "DDB_G0293194", "Q54CL3", "DDB_G0292870", "Q550G0", "DDB_G0277113", "Q54N40", "DDB_G0285523", "Q54C55", "DDB_G0293264", "Q54DG1", "DDB_G0292270", "Q54FR4", "DDB_G0290631", "Q54XX9", "DDB_G0290631", "Q54GD8", "DDB_G0290631", "Q54ZX5", "DDB_G0290631", "Q76P23", "DDB_G0272346", "Q54VX0", "DDB_G0280367", "Q1ZXK7", "DDB_G0276169", "Q55FL0", "DDB_G0268564", "DDB_G0281213", "DDB_G0274873" ] }, "reaction_10625931": { "compartment": "compartment_70101", "id": "reaction_10625931", "reactome": "R-DDI-9603804", "name": "PEX19 binds class I peroxisomal membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625895", "species_10590227" ], "products": [ "species_10625897" ], "modifiers": [], "additional_components": [ "Q54ZX5", "DDB_G0290631", "Q54FR4", "DDB_G0290631", "Q54GD8", "DDB_G0290631", "Q54XX9", "DDB_G0290631", "Q8T8P3", "DDB_G0293194", "Q54N40", "DDB_G0285523", "Q55FL0", "DDB_G0268564", "Q54VX0", "DDB_G0280367", "Q86AC7", "DDB_G0276913", "Q54H86", "DDB_G0289623", "Q54DG1", "DDB_G0292270", "Q54C55", "DDB_G0293264", "Q54CL3", "DDB_G0292870", "Q76P23", "DDB_G0272346", "Q1ZXK7", "DDB_G0276169", "Q550G0", "DDB_G0277113", "DDB_G0274873", "Q555I0", "DDB_G0274873", "Q54ZX5", "DDB_G0290631", "Q54FR4", "DDB_G0290631", "Q54GD8", "DDB_G0290631", "Q54XX9", "DDB_G0290631", "Q8T8P3", "DDB_G0293194", "Q54N40", "DDB_G0285523", "Q55FL0", "DDB_G0268564", "Q54VX0", "DDB_G0280367", "Q86AC7", "DDB_G0276913", "Q54H86", "DDB_G0289623", "Q54DG1", "DDB_G0292270", "Q54C55", "DDB_G0293264", "Q54CL3", "DDB_G0292870", "Q76P23", "DDB_G0272346", "Q1ZXK7", "DDB_G0276169", "Q550G0", "DDB_G0277113" ] }, "reaction_10625929": { "compartment": "compartment_17947", "id": "reaction_10625929", "reactome": "R-DDI-9603784", "name": "PEX19:class I PMP binds PEX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625897", "species_10590211" ], "products": [ "species_10625899" ], "modifiers": [], "additional_components": [ "Q555I0", "DDB_G0274873", "Q54ZX5", "DDB_G0290631", "Q54FR4", "DDB_G0290631", "Q54GD8", "DDB_G0290631", "Q54XX9", "DDB_G0290631", "Q8T8P3", "DDB_G0293194", "Q54N40", "DDB_G0285523", "Q55FL0", "DDB_G0268564", "Q54VX0", "DDB_G0280367", "Q86AC7", "DDB_G0276913", "Q54H86", "DDB_G0289623", "Q54DG1", "DDB_G0292270", "Q54C55", "DDB_G0293264", "Q54CL3", "DDB_G0292870", "Q76P23", "DDB_G0272346", "Q1ZXK7", "DDB_G0276169", "Q550G0", "DDB_G0277113", "DDB_G0281213", "Q54U86", "DDB_G0281213", "Q555I0", "DDB_G0274873", "Q54ZX5", "DDB_G0290631", "Q54FR4", "DDB_G0290631", "Q54GD8", "DDB_G0290631", "Q54XX9", "DDB_G0290631", "Q8T8P3", "DDB_G0293194", "Q54N40", "DDB_G0285523", "Q55FL0", "DDB_G0268564", "Q54VX0", "DDB_G0280367", "Q86AC7", "DDB_G0276913", "Q54H86", "DDB_G0289623", "Q54DG1", "DDB_G0292270", "Q54C55", "DDB_G0293264", "Q54CL3", "DDB_G0292870", "Q76P23", "DDB_G0272346", "Q1ZXK7", "DDB_G0276169", "Q550G0", "DDB_G0277113" ] }, "reaction_10604817": { "compartment": "compartment_70101", "id": "reaction_10604817", "reactome": "R-DDI-5226999", "name": "ADD1:ADD3 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604813", "species_10604805" ], "products": [ "species_10604815" ], "modifiers": [], "additional_components": [ "Q54T47", "DDB_G0282009", "DDB_G0279449", "Q54WT5", "DDB_G0279449", "Q54T47", "DDB_G0282009" ] }, "reaction_10605174": { "compartment": "compartment_70101", "id": "reaction_10605174", "reactome": "R-DDI-5339528", "name": "TUSC3 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10605171", "catalyst" ] ], "additional_components": [ "DDB_G0285537" ] }, "reaction_10604809": { "compartment": "compartment_70101", "id": "reaction_10604809", "reactome": "R-DDI-5226979", "name": "ADD1:ADD2 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604805", "species_10604800" ], "products": [ "species_10604807" ], "modifiers": [], "additional_components": [ "DDB_G0279449", "Q54T47", "DDB_G0282009", "Q54T47", "DDB_G0282009", "Q54WT5", "DDB_G0279449" ] }, "reaction_10605163": { "compartment": "compartment_70101", "id": "reaction_10605163", "reactome": "R-DDI-5336466", "name": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29926" ], "products": [ "species_109496" ], "modifiers": [ [ "species_10605160", "catalyst" ] ], "additional_components": [ "DDB_G0275813" ] }, "reaction_10605179": { "compartment": "compartment_70101", "id": "reaction_10605179", "reactome": "R-DDI-5339538", "name": "MAGT1 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10605176", "catalyst" ] ], "additional_components": [ "DDB_G0285537" ] }, "reaction_10582416": { "compartment": "compartment_7660", "id": "reaction_10582416", "reactome": "R-DDI-77090", "name": "Methylation of GMP-cap by RNA Methyltransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10582409" ], "products": [ "species_10582382", "species_77502", "species_10582413", "species_10580699", "species_10578881" ], "modifiers": [ [ "species_10582409", "catalyst" ] ], "additional_components": [ "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661", "DDB_G0287661", "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661" ] }, "reaction_10582402": { "compartment": "compartment_7660", "id": "reaction_10582402", "reactome": "R-DDI-77081", "name": "Formation of the CE:GMP intermediate complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582392", "species_113571" ], "products": [ "species_10582399", "species_111349" ], "modifiers": [ [ "species_10582392", "catalyst" ] ], "additional_components": [ "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661", "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661", "species_113578", "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661" ] }, "reaction_10582418": { "compartment": "compartment_7660", "id": "reaction_10582418", "reactome": "R-DDI-77094", "name": "Formation of cap binding complex (CBC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10578795", "species_10578800" ], "products": [ "species_10578802" ], "modifiers": [], "additional_components": [ "DDB_G0287197", "DDB_G0269814", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197" ] }, "reaction_10582420": { "compartment": "compartment_7660", "id": "reaction_10582420", "reactome": "R-DDI-77095", "name": "Recognition and binding of the mRNA cap by the cap-binding complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10578802", "species_10578881" ], "products": [ "species_10578883" ], "modifiers": [], "additional_components": [ "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197" ] }, "reaction_10582407": { "compartment": "compartment_7660", "id": "reaction_10582407", "reactome": "R-DDI-77083", "name": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582399" ], "products": [ "species_10582404" ], "modifiers": [ [ "species_10582399", "catalyst" ] ], "additional_components": [ "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661", "species_113578", "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661", "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661", "species_113578" ] }, "reaction_10582390": { "compartment": "compartment_7660", "id": "reaction_10582390", "reactome": "R-DDI-77077", "name": "Capping complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_72084", "species_29428", "species_10582384" ], "products": [ "species_10582388" ], "modifiers": [], "additional_components": [ "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661", "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661" ] }, "reaction_10582395": { "compartment": "compartment_7660", "id": "reaction_10582395", "reactome": "R-DDI-77078", "name": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582388" ], "products": [ "species_113550", "species_10582392" ], "modifiers": [ [ "species_10582388", "catalyst" ] ], "additional_components": [ "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661", "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661", "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661" ] }, "reaction_10582411": { "compartment": "compartment_7660", "id": "reaction_10582411", "reactome": "R-DDI-77085", "name": "Dissociation of transcript with 5'-GMP from GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582404" ], "products": [ "species_10582409" ], "modifiers": [], "additional_components": [ "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661", "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661" ] }, "reaction_10624148": { "compartment": "compartment_7660", "id": "reaction_10624148", "reactome": "R-DDI-8979071", "name": "KDM6B binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602196", "species_111793" ], "products": [ "species_10602198" ], "modifiers": [], "additional_components": [ "DDB_G0269194", "species_71067", "O77033", "DDB_G0269194" ] }, "reaction_10602201": { "compartment": "compartment_7660", "id": "reaction_10602201", "reactome": "R-DDI-3222593", "name": "KDM6B demethylates H3K27me3 on p16INK4A promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602189", "species_113671" ], "products": [ "species_10602191", "species_159939" ], "modifiers": [ [ "species_10602198", "catalyst" ] ], "additional_components": [ "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863", "O15819", "DDB_G0267402", "Q54F38", "DDB_G0291185", "Q76NW2", "DDB_G0276863", "species_71067", "O77033", "DDB_G0269194" ] }, "reaction_10594065": { "compartment": "compartment_70101", "id": "reaction_10594065", "reactome": "R-DDI-708349", "name": "Activated NOD2 oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584517" ], "products": [ "species_10584519" ], "modifiers": [], "additional_components": [ "Q86KC0", "DDB_G0274183", "species_708341", "Q86KC0", "DDB_G0274183", "species_708341" ] }, "reaction_10594037": { "compartment": "compartment_70101", "id": "reaction_10594037", "reactome": "R-DDI-622310", "name": "Activated NOD1 oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584509" ], "products": [ "species_10584513" ], "modifiers": [], "additional_components": [ "species_622271", "Q86KC0", "DDB_G0274183", "species_622271", "Q86KC0", "DDB_G0274183" ] }, "reaction_10627336": { "compartment": "compartment_70101", "id": "reaction_10627336", "reactome": "R-DDI-9676160", "name": "AAMP binds NOD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627244", "species_10584515" ], "products": [ "species_10627334" ], "modifiers": [], "additional_components": [ "DDB_G0269344", "DDB_G0274183", "Q86KC0", "DDB_G0274183", "Q55E90", "DDB_G0269344" ] }, "reaction_10584557": { "compartment": "compartment_70101", "id": "reaction_10584557", "reactome": "R-DDI-168405", "name": "Activated NOD oligomer recruites RIP2 (RICK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584553", "species_10584521" ], "products": [ "species_10584555" ], "modifiers": [], "additional_components": [ "Q54IP4", "DDB_G0288617", "Q54Y55", "DDB_G0278409", "Q86HG9", "DDB_G0271682", "Q54RB7", "DDB_G0283267", "Q54U31", "DDB_G0281343", "Q54G43", "DDB_G0290451", "species_622271", "Q86KC0", "DDB_G0274183", "species_708341", "Q54IP4", "DDB_G0288617", "Q54Y55", "DDB_G0278409", "Q86HG9", "DDB_G0271682", "Q54RB7", "DDB_G0283267", "Q54U31", "DDB_G0281343", "Q54G43", "DDB_G0290451", "species_622271", "Q86KC0", "DDB_G0274183", "species_708341" ] }, "reaction_10584511": { "compartment": "compartment_70101", "id": "reaction_10584511", "reactome": "R-DDI-168400", "name": "iE-DAP elicits a NOD1 response", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584507", "species_622271" ], "products": [ "species_10584509" ], "modifiers": [], "additional_components": [ "DDB_G0274183", "species_622271", "Q86KC0", "DDB_G0274183" ] }, "reaction_10584559": { "compartment": "compartment_70101", "id": "reaction_10584559", "reactome": "R-DDI-168412", "name": "MDP elicits a NOD2 response", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_708341", "species_10584515" ], "products": [ "species_10584517" ], "modifiers": [], "additional_components": [ "DDB_G0274183", "Q86KC0", "DDB_G0274183", "species_708341" ] }, "reaction_10615701": { "compartment": "compartment_1470028", "id": "reaction_10615701", "reactome": "R-DDI-6798751", "name": "Exocytosis of azurophil granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615569" ], "products": [ "species_10615699" ], "modifiers": [], "additional_components": [ "P13723", "DDB_G0287033", "Q559Q3", "DDB_G0272298", "Q54SZ9", "DDB_G0287185", "Q55BL4", "DDB_G0287185", "Q54SW1", "DDB_G0287185", "Q54SW2", "DDB_G0287185", "Q54TL9", "DDB_G0287185", "Q54KP7", "DDB_G0287185", "Q54YD2", "DDB_G0287185", "Q54MV4", "DDB_G0287185", "Q54SZ8", "DDB_G0287185", "Q54VE2", "DDB_G0280423", "Q54P50", "DDB_G0287731", "B0G108", "DDB_G0287731", "Q554H6", "DDB_G0287731", "Q54JY8", "DDB_G0287731", "Q86HR5", "DDB_G0274461", "P34036", "DDB_G0276355", "P34114", "DDB_G0291123", "Q00766", "DDB_G0281383", "Q54QQ0", "DDB_G0283701", "Q8MML4", "DDB_G0274551", "Q54F36", "DDB_G0291137", "Q54XV8", "DDB_G0278563", "Q54HT4", "DDB_G0289231", "Q54H23", "DDB_G0289749", "Q54SE2", "DDB_G0282517", "Q55F06", "DDB_G0279583", "Q54WK5", "DDB_G0279583", "Q54JM5", "DDB_G0287953", "Q54I39", "DDB_G0289029", "Q55FM7", "DDB_G0268034", "O96621", "DDB_G0272106", "C7FZY2", "DDB_G0295845", "Q553U5", "DDB_G0275179", "Q54ES9", "DDB_G0291358", "P54654", "DDB_G0288769", "Q552J0", "DDB_G0276233", "C7G009", "DDB_G0295811", "Q557G3", "DDB_G0273467", "Q54WW0", "DDB_G0290421", "Q54G40", "DDB_G0290421", "Q54EG4", "DDB_G0291524", "Q55B10", "DDB_G0271490", "P32256", "DDB_G0269196", "P34098", "DDB_G0292206", "Q6TMK4", "DDB_G0277275", "Q54LD6", "DDB_G0286691", "P10901", "DDB_G0274391", "Q551C1", "DDB_G0276661", "P90532", "DDB_G0288065", "Q55G10", "DDB_G0268472", "Q54HL4", "DDB_G0289365", "Q54JY2", "DDB_G0287739", "Q1ZXG4", "DDB_G0282361", "P24639", "DDB_G0269160", "Q54PW0", "DDB_G0284261", "Q54HV8", "DDB_G0289195", "Q54YA2", "DDB_G0278341", "Q55BA2", "DDB_G0271242", "Q54GE1", "DDB_G0290217", "P34114", "DDB_G0291123", "Q00766", "DDB_G0281383", "Q54I39", "DDB_G0289029", "P10901", "DDB_G0274391", "Q551C1", "DDB_G0276661", "P90532", "DDB_G0288065", "Q54G40", "DDB_G0290421", "Q54WW0", "DDB_G0290421", "Q552J0", "DDB_G0276233", "P34098", "DDB_G0292206", "Q55FM7", "DDB_G0268034", "Q553U5", "DDB_G0275179", "Q55BA2", "DDB_G0271242", "Q6TMK4", "DDB_G0277275", "Q54QQ0", "DDB_G0283701", "P24639", "DDB_G0269160", "Q54PW0", "DDB_G0284261", "Q55G10", "DDB_G0268472", "Q54YA2", "DDB_G0278341", "Q1ZXG4", "DDB_G0282361", "Q54GE1", "DDB_G0290217", "P13723", "DDB_G0287033", "Q559Q3", "DDB_G0272298", "Q86HR5", "DDB_G0274461", "B0G108", "DDB_G0287731", "Q54JY8", "DDB_G0287731", "Q54P50", "DDB_G0287731", "Q554H6", "DDB_G0287731", "P34036", "DDB_G0276355", "Q54F36", "DDB_G0291137", "Q54XV8", "DDB_G0278563", "Q8MML4", "DDB_G0274551", "Q55F06", "DDB_G0279583", "Q54WK5", "DDB_G0279583", "Q54H23", "DDB_G0289749", "Q54HT4", "DDB_G0289231", "C7FZY2", "DDB_G0295845", "Q54ES9", "DDB_G0291358", "C7G009", "DDB_G0295811", "Q557G3", "DDB_G0273467", "P32256", "DDB_G0269196", "Q54HL4", "DDB_G0289365", "Q54JY2", "DDB_G0287739", "Q54SE2", "DDB_G0282517", "Q54JM5", "DDB_G0287953", "O96621", "DDB_G0272106", "P54654", "DDB_G0288769", "Q54SZ9", "DDB_G0287185", "Q54TL9", "DDB_G0287185", "Q54YD2", "DDB_G0287185", "Q54KP7", "DDB_G0287185", "Q55BL4", "DDB_G0287185", "Q54MV4", "DDB_G0287185", "Q54SW1", "DDB_G0287185", "Q54SW2", "DDB_G0287185", "Q54SZ8", "DDB_G0287185", "Q54LD6", "DDB_G0286691", "Q54VE2", "DDB_G0280423", "Q54HV8", "DDB_G0289195", "Q54EG4", "DDB_G0291524", "Q55B10", "DDB_G0271490" ] }, "reaction_10616165": { "compartment": "compartment_6800424", "id": "reaction_10616165", "reactome": "R-DDI-6800426", "name": "Exocytosis of ficolin-rich granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616149" ], "products": [ "species_10616163" ], "modifiers": [], "additional_components": [ "Q1ZXA8", "DDB_G0292160", "Q54QG5", "DDB_G0283893", "P54642", "DDB_G0274381", "Q54MJ8", "DDB_G0285897", "Q54H23", "DDB_G0289749", "Q557H3", "DDB_G0273473", "Q54R04", "DDB_G0283525", "Q86JN1", "DDB_G0272062", "Q55D50", "DDB_G0269790", "Q869Q3", "DDB_G0274519", "Q86KI1", "DDB_G0273439", "Q54E04", "DDB_G0291858", "Q869V1", "DDB_G0276973", "P34144", "DDB_G0277869", "Q86A88", "DDB_G0274815", "Q54Z16", "DDB_G0289735", "Q54H32", "DDB_G0289735", "Q54U63", "DDB_G0280971", "Q55AV3", "DDB_G0271502", "Q55DM1", "DDB_G0269150", "Q86JF2", "DDB_G0271504", "Q54RQ8", "DDB_G0282925", "Q54CM5", "DDB_G0292814", "Q23924", "DDB_G0284735", "Q54YP0", "DDB_G0278613", "Q559U0", "DDB_G0278613", "Q54U95", "DDB_G0281325", "Q54CI8", "DDB_G0292904", "Q54RQ8", "DDB_G0282925", "Q54U63", "DDB_G0280971", "Q55AV3", "DDB_G0271502", "Q55DM1", "DDB_G0269150", "Q86JF2", "DDB_G0271504", "Q86JN1", "DDB_G0272062", "Q54QG5", "DDB_G0283893", "Q23924", "DDB_G0284735", "Q54E04", "DDB_G0291858", "Q54YP0", "DDB_G0278613", "Q559U0", "DDB_G0278613", "Q54CI8", "DDB_G0292904", "Q86KI1", "DDB_G0273439", "Q55D50", "DDB_G0269790", "Q869Q3", "DDB_G0274519", "Q54CM5", "DDB_G0292814", "P34144", "DDB_G0277869", "Q86A88", "DDB_G0274815", "Q54H23", "DDB_G0289749", "Q869V1", "DDB_G0276973", "Q54U95", "DDB_G0281325", "P54642", "DDB_G0274381", "Q54H32", "DDB_G0289735", "Q54Z16", "DDB_G0289735", "Q54R04", "DDB_G0283525", "Q54MJ8", "DDB_G0285897", "Q557H3", "DDB_G0273473", "Q1ZXA8", "DDB_G0292160" ] }, "reaction_10614836": { "compartment": "compartment_6799713", "id": "reaction_10614836", "reactome": "R-DDI-6798747", "name": "Exocytosis of tertiary granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614736" ], "products": [ "species_10614834" ], "modifiers": [], "additional_components": [ "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q55GA1", "DDB_G0293626", "Q54BH1", "DDB_G0293626", "P54642", "DDB_G0274381", "Q55D50", "DDB_G0269790", "Q55CV4", "DDB_G0270682", "Q55CV5", "DDB_G0269110", "Q55CV7", "DDB_G0270986", "Q55CW7", "DDB_G0269872", "Q54YP0", "DDB_G0278613", "Q559U0", "DDB_G0278613", "Q54QG5", "DDB_G0283893", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q86JN1", "DDB_G0272062", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "Q54LX9", "DDB_G0286315", "Q869V1", "DDB_G0276973", "Q54F59", "DDB_G0291091", "Q86J23", "DDB_G0274833", "Q54F95", "DDB_G0290995", "Q54K65", "DDB_G0290995", "Q86GL4", "DDB_G0287101", "Q9XYS3", "DDB_G0289653", "Q54F44", "DDB_G0291117", "Q867X6", "DDB_G0267460", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q86A88", "DDB_G0274815", "Q54Q49", "DDB_G0284155", "Q54UK0", "DDB_G0281031", "Q54WR4", "DDB_G0279483", "Q54Z25", "DDB_G0277949", "Q23924", "DDB_G0284735", "Q54U95", "DDB_G0281325", "Q54U08", "DDB_G0281401", "Q54RQ8", "DDB_G0282925", "Q54U63", "DDB_G0280971", "Q86JF2", "DDB_G0271504", "Q55AV3", "DDB_G0271502", "Q55DM1", "DDB_G0269150", "Q54CM5", "DDB_G0292814", "P36410", "DDB_G0281337", "Q54L55", "DDB_G0286891", "Q551T0", "DDB_G0286891", "Q553A4", "DDB_G0286891", "Q55E61", "DDB_G0286891", "Q86H52", "DDB_G0286891", "Q867X6", "DDB_G0267460", "Q86JN1", "DDB_G0272062", "Q54QG5", "DDB_G0283893", "Q23924", "DDB_G0284735", "Q54BH1", "DDB_G0293626", "Q55GA1", "DDB_G0293626", "Q54F95", "DDB_G0290995", "Q54K65", "DDB_G0290995", "Q55CV4", "DDB_G0270682", "Q55CV5", "DDB_G0269110", "Q55CV7", "DDB_G0270986", "Q55CW7", "DDB_G0269872", "Q86A88", "DDB_G0274815", "Q869V1", "DDB_G0276973", "Q54U08", "DDB_G0281401", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54RQ8", "DDB_G0282925", "Q54U63", "DDB_G0280971", "Q55AV3", "DDB_G0271502", "Q55DM1", "DDB_G0269150", "Q86JF2", "DDB_G0271504", "P36410", "DDB_G0281337", "Q54YP0", "DDB_G0278613", "Q559U0", "DDB_G0278613", "Q55D50", "DDB_G0269790", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "Q54CM5", "DDB_G0292814", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54U95", "DDB_G0281325", "Q54F59", "DDB_G0291091", "Q54WR4", "DDB_G0279483", "Q54Z25", "DDB_G0277949", "Q54Q49", "DDB_G0284155", "Q54UK0", "DDB_G0281031", "P54642", "DDB_G0274381", "Q55E61", "DDB_G0286891", "Q86H52", "DDB_G0286891", "Q54L55", "DDB_G0286891", "Q551T0", "DDB_G0286891", "Q553A4", "DDB_G0286891", "Q86J23", "DDB_G0274833", "Q54LX9", "DDB_G0286315", "Q54F44", "DDB_G0291117", "Q86GL4", "DDB_G0287101", "Q9XYS3", "DDB_G0289653" ] }, "reaction_10616436": { "compartment": "compartment_984", "id": "reaction_10616436", "reactome": "R-DDI-6800434", "name": "Exocytosis of ficolin-rich granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616414" ], "products": [ "species_10616434" ], "modifiers": [], "additional_components": [ "Q54UJ0", "DDB_G0281051", "P04989", "DDB_G0279799", "Q23894", "DDB_G0283867", "Q54RQ2", "DDB_G0282991", "Q54TR1", "DDB_G0281605", "Q54UH2", "DDB_G0282991", "Q54UH3", "DDB_G0282991", "Q86KD4", "DDB_G0282991", "Q54UB5", "DDB_G0281315", "Q86JA1", "DDB_G0276917", "Q54PN7", "DDB_G0284415", "Q556L1", "DDB_G0272590", "P90532", "DDB_G0288065", "P15112", "DDB_G0288373", "Q55GA9", "DDB_G0267742", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "O96626", "DDB_G0288319", "Q54I79", "DDB_G0288937", "Q54JY2", "DDB_G0287739", "C7G034", "DDB_G0285063", "O96621", "DDB_G0272106", "Q54PG1", "DDB_G0284589", "Q54YA2", "DDB_G0278341", "B0G198", "DDB_G0295683", "Q54GE1", "DDB_G0290217", "Q55E06", "DDB_G0269444", "Q54QQ0", "DDB_G0283701", "Q54RF5", "DDB_G0283247", "Q552J0", "DDB_G0276233", "Q54I82", "DDB_G0288933", "Q75JR2", "DDB_G0272210", "Q5R1U3", "DDB_G0277001", "Q556T3", "DDB_G0273107", "Q54QS2", "DDB_G0283663", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54B14", "DDB_G0293986", "Q55FR5", "DDB_G0267990", "Q54K94", "DDB_G0287569", "Q556U5", "DDB_G0273095", "Q54QV7", "DDB_G0283575", "Q54VI4", "DDB_G0280317", "Q556G3", "DDB_G0272632", "Q556P3", "DDB_G0273153", "Q55FF3", "DDB_G0268138", "Q86AU1", "DDB_G0274263", "Q54PF1", "DDB_G0284601", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "C7G028", "DDB_G0284307", "Q8MUF9", "DDB_G0269200", "Q5V9E9", "DDB_G0283673", "Q54UQ2", "DDB_G0280897", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "Q23919", "DDB_G0288483", "Q54S93", "DDB_G0282595", "O96923", "DDB_G0291125", "P10733", "DDB_G0289327", "Q551I6", "DDB_G0276571", "Q86CR9", "DDB_G0271096", "Q54QS3", "DDB_G0283661", "Q54MA9", "DDB_G0286069", "Q54W35", "DDB_G0279909", "Q86A67", "DDB_G0274375", "Q54DD0", "DDB_G0292266", "Q54NQ0", "DDB_G0285105", "Q86IJ1", "DDB_G0272566", "Q54BC6", "DDB_G0293752", "Q54QK4", "DDB_G0283795", "Q1ZXD3", "DDB_G0288621", "Q86KD1", "DDB_G0274167", "Q55C75", "DDB_G0270188", "Q54WI8", "DDB_G0279633", "O77229", "DDB_G0274595", "Q00766", "DDB_G0281383", "Q54IS1", "DDB_G0288563", "Q54L24", "DDB_G0286945", "O76856", "DDB_G0279411", "P36415", "DDB_G0269144", "P54651", "DDB_G0267400", "Q55C24", "DDB_G0270260", "P52922", "DDB_G0269148", "Q54QR2", "DDB_G0283679", "P34118", "DDB_G0269156", "Q54DM7", "DDB_G0292122", "Q55G04", "DDB_G0268538", "Q86A21", "DDB_G0272969", "P34093", "DDB_G0279911", "Q555L5", "DDB_G0274859", "Q54NE6", "DDB_G0285311", "Q54J84", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54VR1", "DDB_G0288221", "C7G034", "DDB_G0285063", "Q8MUF9", "DDB_G0269200", "Q54PG1", "DDB_G0284589", "Q55GA9", "DDB_G0267742", "Q55E06", "DDB_G0269444", "Q556U5", "DDB_G0273095", "P34093", "DDB_G0279911", "Q86JA1", "DDB_G0276917", "Q86A21", "DDB_G0272969", "Q54UB5", "DDB_G0281315", "Q55G04", "DDB_G0268538", "Q54UJ0", "DDB_G0281051", "Q54DM7", "DDB_G0292122", "Q54NQ0", "DDB_G0285105", "P34118", "DDB_G0269156", "Q86IJ1", "DDB_G0272566", "O96621", "DDB_G0272106", "Q54QR2", "DDB_G0283679", "Q54BC6", "DDB_G0293752", "Q1ZXD3", "DDB_G0288621", "P54651", "DDB_G0267400", "Q55C75", "DDB_G0270188", "Q54JY2", "DDB_G0287739", "P36415", "DDB_G0269144", "Q54WI8", "DDB_G0279633", "Q54L24", "DDB_G0286945", "Q54K94", "DDB_G0287569", "Q00766", "DDB_G0281383", "Q23919", "DDB_G0288483", "P52922", "DDB_G0269148", "Q556G3", "DDB_G0272632", "Q556P3", "DDB_G0273153", "Q55FF3", "DDB_G0268138", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q54VI4", "DDB_G0280317", "Q86CR9", "DDB_G0271096", "Q54QS3", "DDB_G0283661", "Q54MA9", "DDB_G0286069", "Q54W35", "DDB_G0279909", "Q55C24", "DDB_G0270260", "Q54GE1", "DDB_G0290217", "Q54DD0", "DDB_G0292266", "Q54YA2", "DDB_G0278341", "O96626", "DDB_G0288319", "Q86A67", "DDB_G0274375", "Q54I79", "DDB_G0288937", "Q54QQ0", "DDB_G0283701", "Q552J0", "DDB_G0276233", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54VR1", "DDB_G0288221", "Q54J84", "DDB_G0288221", "P90532", "DDB_G0288065", "Q54NE6", "DDB_G0285311", "Q556L1", "DDB_G0272590", "Q555L5", "DDB_G0274859", "Q54PN7", "DDB_G0284415", "Q54UH2", "DDB_G0282991", "Q54UH3", "DDB_G0282991", "Q86KD4", "DDB_G0282991", "P04989", "DDB_G0279799", "Q23894", "DDB_G0283867", "Q54RQ2", "DDB_G0282991", "Q54TR1", "DDB_G0281605", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "P15112", "DDB_G0288373", "Q54IS1", "DDB_G0288563", "Q54QK4", "DDB_G0283795", "P10733", "DDB_G0289327", "Q551I6", "DDB_G0276571", "O96923", "DDB_G0291125", "Q54S93", "DDB_G0282595", "B0G198", "DDB_G0295683", "Q54UQ2", "DDB_G0280897", "Q5V9E9", "DDB_G0283673", "Q54NT2", "DDB_G0284997", "Q54IA6", "DDB_G0288895", "Q75JR2", "DDB_G0272210", "C7G028", "DDB_G0284307", "Q54B14", "DDB_G0293986", "Q54PF1", "DDB_G0284601", "Q55FR5", "DDB_G0267990", "O77229", "DDB_G0274595", "Q86KD1", "DDB_G0274167", "Q54I82", "DDB_G0288933", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q5R1U3", "DDB_G0277001", "O76856", "DDB_G0279411", "Q556T3", "DDB_G0273107", "Q54RF5", "DDB_G0283247" ] }, "reaction_10615963": { "compartment": "compartment_6799351", "id": "reaction_10615963", "reactome": "R-DDI-6799350", "name": "Exocytosis of specific granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615937" ], "products": [ "species_10615961" ], "modifiers": [], "additional_components": [ "Q54I48", "DDB_G0289013", "Q54IJ2", "DDB_G0288717", "Q867X6", "DDB_G0267460", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q86A77", "DDB_G0274331", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "Q54U08", "DDB_G0281401", "Q02465", "DDB_G0289075", "Q54F44", "DDB_G0291117", "Q86GL4", "DDB_G0287101", "Q9XYS3", "DDB_G0289653", "Q54CM5", "DDB_G0292814", "Q54LX9", "DDB_G0286315", "Q54F59", "DDB_G0291091", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "P34138", "DDB_G0277865", "P54637", "DDB_G0282145", "Q86J23", "DDB_G0274833", "Q55BH9", "DDB_G0271342", "Q54EU4", "DDB_G0291332", "Q54HS9", "DDB_G0289247", "Q54DG1", "DDB_G0292270", "Q54F95", "DDB_G0290995", "Q54K65", "DDB_G0290995", "Q55FQ9", "DDB_G0267440", "Q9BKJ9", "DDB_G0287035", "Q9XYS8", "DDB_G0267406", "Q54BH1", "DDB_G0293626", "Q55GA1", "DDB_G0293626", "Q54Z55", "DDB_G0277773", "Q869T7", "DDB_G0274409", "Q54S39", "DDB_G0282683", "O76173", "DDB_G0269174", "Q54L55", "DDB_G0286891", "Q551T0", "DDB_G0286891", "Q553A4", "DDB_G0286891", "Q55E61", "DDB_G0286891", "Q86H52", "DDB_G0286891", "Q54S63", "DDB_G0282651", "Q55EF0", "DDB_G0269262", "Q55EG6", "DDB_G0268910", "Q86JC8", "DDB_G0275955", "Q86JP5", "DDB_G0271980", "Q8T193", "DDB_G0294577", "Q1ZXG2", "DDB_G0294577", "Q1ZXN9", "DDB_G0294577", "Q54E92", "DDB_G0291738", "Q54FL2", "DDB_G0290783", "Q54G48", "DDB_G0290407", "Q54P07", "DDB_G0285051", "Q54S62", "DDB_G0294577", "Q551J1", "DDB_G0276567", "Q55D94", "DDB_G0269738", "Q559U0", "DDB_G0278613", "Q54YP0", "DDB_G0278613", "Q1ZXA8", "DDB_G0292160", "Q54QG5", "DDB_G0283893", "Q54Q49", "DDB_G0284155", "Q54UK0", "DDB_G0281031", "Q54WR4", "DDB_G0279483", "Q54Z25", "DDB_G0277949", "Q55CV4", "DDB_G0270682", "Q55CV5", "DDB_G0269110", "Q55CV7", "DDB_G0270986", "Q55CW7", "DDB_G0269872", "Q867X6", "DDB_G0267460", "O76173", "DDB_G0269174", "Q54QG5", "DDB_G0283893", "Q54BH1", "DDB_G0293626", "Q55GA1", "DDB_G0293626", "Q54F95", "DDB_G0290995", "Q54K65", "DDB_G0290995", "Q54DG1", "DDB_G0292270", "Q55CV4", "DDB_G0270682", "Q55CV5", "DDB_G0269110", "Q55CV7", "DDB_G0270986", "Q55CW7", "DDB_G0269872", "Q54U08", "DDB_G0281401", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54I48", "DDB_G0289013", "Q54IJ2", "DDB_G0288717", "Q54EU4", "DDB_G0291332", "Q54HS9", "DDB_G0289247", "Q55D94", "DDB_G0269738", "Q55BH9", "DDB_G0271342", "Q54YP0", "DDB_G0278613", "Q559U0", "DDB_G0278613", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "Q54CM5", "DDB_G0292814", "Q54S63", "DDB_G0282651", "Q55EF0", "DDB_G0269262", "Q55EG6", "DDB_G0268910", "Q86JC8", "DDB_G0275955", "Q86JP5", "DDB_G0271980", "Q8T193", "DDB_G0294577", "Q1ZXG2", "DDB_G0294577", "Q1ZXN9", "DDB_G0294577", "Q54E92", "DDB_G0291738", "Q54FL2", "DDB_G0290783", "Q54G48", "DDB_G0290407", "Q54P07", "DDB_G0285051", "Q54S62", "DDB_G0294577", "P34138", "DDB_G0277865", "P54637", "DDB_G0282145", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54S39", "DDB_G0282683", "Q869T7", "DDB_G0274409", "Q86A77", "DDB_G0274331", "Q9XYS8", "DDB_G0267406", "Q55FQ9", "DDB_G0267440", "Q9BKJ9", "DDB_G0287035", "Q55E61", "DDB_G0286891", "Q86H52", "DDB_G0286891", "Q54L55", "DDB_G0286891", "Q551T0", "DDB_G0286891", "Q553A4", "DDB_G0286891", "Q54WR4", "DDB_G0279483", "Q54Z25", "DDB_G0277949", "Q54Q49", "DDB_G0284155", "Q54UK0", "DDB_G0281031", "Q54F59", "DDB_G0291091", "Q02465", "DDB_G0289075", "Q551J1", "DDB_G0276567", "Q54LX9", "DDB_G0286315", "Q86J23", "DDB_G0274833", "Q54Z55", "DDB_G0277773", "Q54F44", "DDB_G0291117", "Q86GL4", "DDB_G0287101", "Q9XYS3", "DDB_G0289653", "Q1ZXA8", "DDB_G0292160" ] }, "reaction_10614058": { "compartment": "compartment_6798757", "id": "reaction_10614058", "reactome": "R-DDI-6798739", "name": "Exocytosis of azurophil granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613932" ], "products": [ "species_10614056" ], "modifiers": [], "additional_components": [ "Q54F95", "DDB_G0290995", "Q54K65", "DDB_G0290995", "Q54U08", "DDB_G0281401", "Q54X10", "DDB_G0279277", "Q54R04", "DDB_G0283525", "Q54DE8", "DDB_G0292310", "Q54ET2", "DDB_G0291352", "P18613", "DDB_G0291237", "Q552S3", "DDB_G0275917", "Q54FL2", "DDB_G0290783", "Q54G48", "DDB_G0290407", "Q54P07", "DDB_G0285051", "Q54S62", "DDB_G0294577", "Q54S63", "DDB_G0282651", "Q55EF0", "DDB_G0269262", "Q55EG6", "DDB_G0268910", "Q86JC8", "DDB_G0275955", "Q86JP5", "DDB_G0271980", "Q8T193", "DDB_G0294577", "Q1ZXG2", "DDB_G0294577", "Q1ZXN9", "DDB_G0294577", "Q54E92", "DDB_G0291738", "Q86JP3", "DDB_G0271984", "Q54FY7", "DDB_G0290529", "Q54P51", "DDB_G0284791", "Q55GG1", "DDB_G0267688", "Q7YXU4", "DDB_G0293008", "Q86K21", "DDB_G0272875", "Q1ZXB3", "DDB_G0291498", "Q54H23", "DDB_G0289749", "Q556J9", "DDB_G0272889", "Q54WE0", "DDB_G0279713", "Q55GN5", "DDB_G0267590", "P54642", "DDB_G0274381", "Q54XS7", "DDB_G0278773", "Q54LZ3", "DDB_G0286293", "Q54E62", "DDB_G0291780", "Q551J1", "DDB_G0276567", "O76173", "DDB_G0269174", "Q1ZXA8", "DDB_G0292160", "Q54P71", "DDB_G0284755", "Q54P72", "DDB_G0284755", "Q54PR9", "DDB_G0284363", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q8T6J2", "DDB_G0274119", "Q8T6J5", "DDB_G0267438", "Q54BT5", "DDB_G0293436", "Q555Z5", "DDB_G0274121", "Q55BC0", "DDB_G0271138", "Q8T5Z7", "DDB_G0291994", "Q8T6J1", "DDB_G0291245", "Q55D50", "DDB_G0269790", "Q54N33", "DDB_G0285537", "P20790", "DDB_G0280043", "P20791", "DDB_G0276399", "Q1ZXE7", "DDB_G0286169", "Q54RY4", "DDB_G0282899", "Q54JT7", "DDB_G0287801", "Q54WG1", "DDB_G0279675", "O76173", "DDB_G0269174", "Q54DE8", "DDB_G0292310", "Q54ET2", "DDB_G0291352", "Q54WG1", "DDB_G0279675", "Q54F95", "DDB_G0290995", "Q54K65", "DDB_G0290995", "Q54X10", "DDB_G0279277", "Q54U08", "DDB_G0281401", "Q552S3", "DDB_G0275917", "P20790", "DDB_G0280043", "P20791", "DDB_G0276399", "Q1ZXE7", "DDB_G0286169", "Q54RY4", "DDB_G0282899", "Q54E62", "DDB_G0291780", "Q54LZ3", "DDB_G0286293", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54N33", "DDB_G0285537", "Q54P51", "DDB_G0284791", "Q55GG1", "DDB_G0267688", "Q1ZXB3", "DDB_G0291498", "Q54FY7", "DDB_G0290529", "Q7YXU4", "DDB_G0293008", "Q86K21", "DDB_G0272875", "Q8T6J2", "DDB_G0274119", "Q8T6J5", "DDB_G0267438", "Q54BT5", "DDB_G0293436", "Q555Z5", "DDB_G0274121", "Q55BC0", "DDB_G0271138", "Q8T5Z7", "DDB_G0291994", "Q8T6J1", "DDB_G0291245", "P18613", "DDB_G0291237", "Q54JT7", "DDB_G0287801", "Q54S63", "DDB_G0282651", "Q55EF0", "DDB_G0269262", "Q55EG6", "DDB_G0268910", "Q86JC8", "DDB_G0275955", "Q86JP5", "DDB_G0271980", "Q8T193", "DDB_G0294577", "Q1ZXG2", "DDB_G0294577", "Q1ZXN9", "DDB_G0294577", "Q54E92", "DDB_G0291738", "Q54FL2", "DDB_G0290783", "Q54G48", "DDB_G0290407", "Q54P07", "DDB_G0285051", "Q54S62", "DDB_G0294577", "Q54P71", "DDB_G0284755", "Q54P72", "DDB_G0284755", "Q54PR9", "DDB_G0284363", "Q86JP3", "DDB_G0271984", "Q54H23", "DDB_G0289749", "Q556J9", "DDB_G0272889", "Q54WE0", "DDB_G0279713", "Q55GN5", "DDB_G0267590", "P54642", "DDB_G0274381", "Q551J1", "DDB_G0276567", "Q54XS7", "DDB_G0278773", "Q54R04", "DDB_G0283525", "Q55D50", "DDB_G0269790", "Q1ZXA8", "DDB_G0292160" ] }, "reaction_10615338": { "compartment": "compartment_6799371", "id": "reaction_10615338", "reactome": "R-DDI-6798749", "name": "Exocytosis of specific granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615290" ], "products": [ "species_10615336" ], "modifiers": [], "additional_components": [ "Q54B14", "DDB_G0293986", "Q55BA2", "DDB_G0271242", "Q54HV8", "DDB_G0289195", "Q54F36", "DDB_G0291137", "Q54XV8", "DDB_G0278563", "Q8MML4", "DDB_G0274551", "O76856", "DDB_G0279411", "P05095", "DDB_G0268632", "Q54V78", "DDB_G0280565", "Q55D97", "DDB_G0270626", "Q54RX2", "DDB_G0282859", "Q54PB7", "DDB_G0292004", "Q54HL4", "DDB_G0289365", "Q54J84", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54VR1", "DDB_G0288221", "Q54JM9", "DDB_G0287939", "Q1ZXG2", "DDB_G0294577", "Q1ZXN9", "DDB_G0294577", "Q54E92", "DDB_G0291738", "Q54FL2", "DDB_G0290783", "Q54G48", "DDB_G0290407", "Q54P07", "DDB_G0285051", "Q54S62", "DDB_G0294577", "Q54S63", "DDB_G0282651", "Q55EF0", "DDB_G0269262", "Q55EG6", "DDB_G0268910", "Q86JC8", "DDB_G0275955", "Q86JP5", "DDB_G0271980", "Q8T193", "DDB_G0294577", "Q86IY4", "DDB_G0274339", "Q556T3", "DDB_G0273107", "Q55EK9", "DDB_G0268628", "Q6UK63", "DDB_G0287855", "Q6UK63", "DDB_G0287855", "Q54F36", "DDB_G0291137", "Q54XV8", "DDB_G0278563", "Q8MML4", "DDB_G0274551", "Q55EK9", "DDB_G0268628", "P05095", "DDB_G0268632", "Q54V78", "DDB_G0280565", "Q54B14", "DDB_G0293986", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54VR1", "DDB_G0288221", "Q54J84", "DDB_G0288221", "Q54JM9", "DDB_G0287939", "Q55BA2", "DDB_G0271242", "Q54RX2", "DDB_G0282859", "Q54HL4", "DDB_G0289365", "Q55D97", "DDB_G0270626", "O76856", "DDB_G0279411", "Q1ZXG2", "DDB_G0294577", "Q1ZXN9", "DDB_G0294577", "Q54E92", "DDB_G0291738", "Q54FL2", "DDB_G0290783", "Q54G48", "DDB_G0290407", "Q54P07", "DDB_G0285051", "Q54S62", "DDB_G0294577", "Q54S63", "DDB_G0282651", "Q55EF0", "DDB_G0269262", "Q55EG6", "DDB_G0268910", "Q86JC8", "DDB_G0275955", "Q86JP5", "DDB_G0271980", "Q8T193", "DDB_G0294577", "Q54PB7", "DDB_G0292004", "Q54HV8", "DDB_G0289195", "Q86IY4", "DDB_G0274339", "Q556T3", "DDB_G0273107" ] }, "reaction_10615210": { "compartment": "compartment_1462052", "id": "reaction_10615210", "reactome": "R-DDI-6798748", "name": "Exocytosis of secretory granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615050" ], "products": [ "species_10615208" ], "modifiers": [], "additional_components": [ "Q54NQ0", "DDB_G0285105", "Q86A67", "DDB_G0274375", "Q86IJ1", "DDB_G0272566", "P15112", "DDB_G0288373", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "Q555L5", "DDB_G0274859", "P34093", "DDB_G0279911", "Q86A21", "DDB_G0272969", "Q55G04", "DDB_G0268538", "Q54DM7", "DDB_G0292122", "P34118", "DDB_G0269156", "Q86CR9", "DDB_G0271096", "Q54QR2", "DDB_G0283679", "Q54QS3", "DDB_G0283661", "Q55C24", "DDB_G0270260", "P54651", "DDB_G0267400", "Q54LY5", "DDB_G0286303", "P36415", "DDB_G0269144", "Q54MA9", "DDB_G0286069", "Q54L24", "DDB_G0286945", "Q54W35", "DDB_G0279909", "Q00766", "DDB_G0281383", "Q54DD0", "DDB_G0292266", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q54VI4", "DDB_G0280317", "Q556G3", "DDB_G0272632", "Q556P3", "DDB_G0273153", "Q55FF3", "DDB_G0268138", "O96626", "DDB_G0288319", "Q54I79", "DDB_G0288937", "Q86KD1", "DDB_G0274167", "B0G198", "DDB_G0295683", "Q54UH3", "DDB_G0282991", "Q86KD4", "DDB_G0282991", "P04989", "DDB_G0279799", "Q23894", "DDB_G0283867", "Q54RQ2", "DDB_G0282991", "Q54TR1", "DDB_G0281605", "Q54UH2", "DDB_G0282991", "Q54E35", "DDB_G0291840", "O77229", "DDB_G0274595", "Q54PF1", "DDB_G0284601", "Q6TMK4", "DDB_G0277275", "C7G028", "DDB_G0284307", "Q54NE6", "DDB_G0285311", "Q54BC6", "DDB_G0293752", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "Q1ZXD3", "DDB_G0288621", "Q55C75", "DDB_G0270188", "Q54WI8", "DDB_G0279633", "C7G034", "DDB_G0285063", "Q54K94", "DDB_G0287569", "Q54PG1", "DDB_G0284589", "Q55E06", "DDB_G0269444", "Q54RF5", "DDB_G0283247", "Q54I82", "DDB_G0288933", "Q5R1U3", "DDB_G0277001", "Q54QS2", "DDB_G0283663", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54UJ0", "DDB_G0281051", "Q54UB5", "DDB_G0281315", "Q86JA1", "DDB_G0276917", "O96923", "DDB_G0291125", "P10733", "DDB_G0289327", "Q551I6", "DDB_G0276571", "Q54PN7", "DDB_G0284415", "Q556L1", "DDB_G0272590", "P90532", "DDB_G0288065", "Q75JR2", "DDB_G0272210", "Q54S93", "DDB_G0282595", "Q6UK63", "DDB_G0287855", "Q54UQ2", "DDB_G0280897", "Q556T3", "DDB_G0273107", "Q5V9E9", "DDB_G0283673", "Q55EK9", "DDB_G0268628", "Q552J0", "DDB_G0276233", "Q55FM7", "DDB_G0268034", "Q54QQ0", "DDB_G0283701", "Q54S93", "DDB_G0282595", "P10733", "DDB_G0289327", "Q551I6", "DDB_G0276571", "O96923", "DDB_G0291125", "P15112", "DDB_G0288373", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "Q54UH2", "DDB_G0282991", "Q54UH3", "DDB_G0282991", "Q86KD4", "DDB_G0282991", "P04989", "DDB_G0279799", "Q23894", "DDB_G0283867", "Q54RQ2", "DDB_G0282991", "Q54TR1", "DDB_G0281605", "C7G034", "DDB_G0285063", "Q54PG1", "DDB_G0284589", "Q55E06", "DDB_G0269444", "P34093", "DDB_G0279911", "Q86JA1", "DDB_G0276917", "Q86A21", "DDB_G0272969", "Q54UB5", "DDB_G0281315", "Q55G04", "DDB_G0268538", "Q54UJ0", "DDB_G0281051", "Q54DM7", "DDB_G0292122", "Q54NQ0", "DDB_G0285105", "P34118", "DDB_G0269156", "Q86IJ1", "DDB_G0272566", "Q54QR2", "DDB_G0283679", "Q54BC6", "DDB_G0293752", "Q1ZXD3", "DDB_G0288621", "P54651", "DDB_G0267400", "Q55C75", "DDB_G0270188", "P36415", "DDB_G0269144", "Q54WI8", "DDB_G0279633", "Q54L24", "DDB_G0286945", "Q54K94", "DDB_G0287569", "Q00766", "DDB_G0281383", "Q556G3", "DDB_G0272632", "Q556P3", "DDB_G0273153", "Q55FF3", "DDB_G0268138", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q54VI4", "DDB_G0280317", "Q86CR9", "DDB_G0271096", "Q54QS3", "DDB_G0283661", "Q54LY5", "DDB_G0286303", "Q54MA9", "DDB_G0286069", "Q54W35", "DDB_G0279909", "Q55C24", "DDB_G0270260", "Q54DD0", "DDB_G0292266", "O96626", "DDB_G0288319", "Q86A67", "DDB_G0274375", "Q54I79", "DDB_G0288937", "Q54QQ0", "DDB_G0283701", "Q55FM7", "DDB_G0268034", "Q552J0", "DDB_G0276233", "Q54E35", "DDB_G0291840", "Q55EK9", "DDB_G0268628", "Q6TMK4", "DDB_G0277275", "P90532", "DDB_G0288065", "Q54NE6", "DDB_G0285311", "Q556L1", "DDB_G0272590", "Q555L5", "DDB_G0274859", "Q54PN7", "DDB_G0284415", "B0G198", "DDB_G0295683", "Q54UQ2", "DDB_G0280897", "Q5V9E9", "DDB_G0283673", "Q6UK63", "DDB_G0287855", "Q54NT2", "DDB_G0284997", "Q54IA6", "DDB_G0288895", "Q75JR2", "DDB_G0272210", "C7G028", "DDB_G0284307", "Q54PF1", "DDB_G0284601", "O77229", "DDB_G0274595", "Q86KD1", "DDB_G0274167", "Q54I82", "DDB_G0288933", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q5R1U3", "DDB_G0277001", "Q556T3", "DDB_G0273107", "Q54RF5", "DDB_G0283247" ] }, "reaction_10614349": { "compartment": "compartment_876", "id": "reaction_10614349", "reactome": "R-DDI-6798743", "name": "Exocytosis of secretory granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614243" ], "products": [ "species_10614347" ], "modifiers": [], "additional_components": [ "Q54YP0", "DDB_G0278613", "Q559U0", "DDB_G0278613", "Q54K32", "DDB_G0287585", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "P34144", "DDB_G0277869", "Q86KI1", "DDB_G0273439", "Q54GY8", "DDB_G0289827", "Q54CM5", "DDB_G0292814", "Q23924", "DDB_G0284735", "Q54DG1", "DDB_G0292270", "Q8MYF2", "DDB_G0277441", "Q55FU9", "DDB_G0268402", "Q54RY4", "DDB_G0282899", "P20790", "DDB_G0280043", "P20791", "DDB_G0276399", "Q1ZXE7", "DDB_G0286169", "Q8T6J2", "DDB_G0274119", "Q8T6J5", "DDB_G0267438", "Q54BT5", "DDB_G0293436", "Q555Z5", "DDB_G0274121", "Q55BC0", "DDB_G0271138", "Q8T5Z7", "DDB_G0291994", "Q8T6J1", "DDB_G0291245", "Q54LZ3", "DDB_G0286293", "Q54E04", "DDB_G0291858", "Q54DA7", "DDB_G0292406", "Q54CI8", "DDB_G0292904", "Q86JP3", "DDB_G0271984", "Q869Q3", "DDB_G0274519", "Q55FK2", "DDB_G0268068", "P36411", "DDB_G0269236", "Q557I4", "DDB_G0273419", "Q55CT4", "DDB_G0270994", "Q55CY7", "DDB_G0270670", "P34138", "DDB_G0277865", "Q54FK4", "DDB_G0290833", "Q54FK8", "DDB_G0290829", "Q1ZXB8", "DDB_G0294571", "Q54K69", "DDB_G0287553", "Q1ZXB9", "DDB_G0290831", "Q54FK5", "DDB_G0290789", "Q54FK7", "DDB_G0290779", "Q552H0", "DDB_G0294571", "Q1ZXB7", "DDB_G0290791", "Q54FK2", "DDB_G0290793", "Q54K32", "DDB_G0287585", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "Q23924", "DDB_G0284735", "Q54GY8", "DDB_G0289827", "Q54E04", "DDB_G0291858", "Q8MYF2", "DDB_G0277441", "Q54CI8", "DDB_G0292904", "Q55FU9", "DDB_G0268402", "P34138", "DDB_G0277865", "Q86KI1", "DDB_G0273439", "Q869Q3", "DDB_G0274519", "Q54DG1", "DDB_G0292270", "Q54RY4", "DDB_G0282899", "P20790", "DDB_G0280043", "P20791", "DDB_G0276399", "Q1ZXE7", "DDB_G0286169", "Q54DA7", "DDB_G0292406", "Q54LZ3", "DDB_G0286293", "Q86JP3", "DDB_G0271984", "Q55FK2", "DDB_G0268068", "P36411", "DDB_G0269236", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q55CY7", "DDB_G0270670", "Q557I4", "DDB_G0273419", "Q55CT4", "DDB_G0270994", "Q8T6J2", "DDB_G0274119", "Q8T6J5", "DDB_G0267438", "Q54BT5", "DDB_G0293436", "Q555Z5", "DDB_G0274121", "Q55BC0", "DDB_G0271138", "Q8T5Z7", "DDB_G0291994", "Q8T6J1", "DDB_G0291245", "Q54YP0", "DDB_G0278613", "Q559U0", "DDB_G0278613", "Q54CM5", "DDB_G0292814", "P34144", "DDB_G0277869", "Q54FK5", "DDB_G0290789", "Q54FK7", "DDB_G0290779", "Q54FK8", "DDB_G0290829", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "Q1ZXB8", "DDB_G0294571", "Q552H0", "DDB_G0294571", "Q1ZXB9", "DDB_G0290831", "Q54FK2", "DDB_G0290793", "Q54FK4", "DDB_G0290833" ] }, "reaction_10614542": { "compartment": "compartment_6800173", "id": "reaction_10614542", "reactome": "R-DDI-6798745", "name": "Exocytosis of tertiary granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614462" ], "products": [ "species_10614540" ], "modifiers": [], "additional_components": [ "Q55FR5", "DDB_G0267990", "Q54JM9", "DDB_G0287939", "Q54XV8", "DDB_G0278563", "Q8MML4", "DDB_G0274551", "Q54F36", "DDB_G0291137", "Q54HL4", "DDB_G0289365", "O76856", "DDB_G0279411", "Q54RQ2", "DDB_G0282991", "Q54TR1", "DDB_G0281605", "Q54UH2", "DDB_G0282991", "Q54UH3", "DDB_G0282991", "Q86KD4", "DDB_G0282991", "P04989", "DDB_G0279799", "Q23894", "DDB_G0283867", "Q54RX2", "DDB_G0282859", "Q6UK63", "DDB_G0287855", "Q5R1U3", "DDB_G0277001", "Q75JR2", "DDB_G0272210", "Q55D97", "DDB_G0270626", "Q54I82", "DDB_G0288933", "B0G198", "DDB_G0295683", "Q86A67", "DDB_G0274375", "P05095", "DDB_G0268632", "Q54V78", "DDB_G0280565", "Q54B14", "DDB_G0293986", "Q550I3", "DDB_G0277093", "Q23919", "DDB_G0288483", "P52922", "DDB_G0269148", "Q6UK63", "DDB_G0287855", "Q54F36", "DDB_G0291137", "Q54XV8", "DDB_G0278563", "Q8MML4", "DDB_G0274551", "Q550I3", "DDB_G0277093", "Q75JR2", "DDB_G0272210", "Q54B14", "DDB_G0293986", "Q54UH2", "DDB_G0282991", "Q54UH3", "DDB_G0282991", "Q86KD4", "DDB_G0282991", "P04989", "DDB_G0279799", "Q23894", "DDB_G0283867", "Q54RQ2", "DDB_G0282991", "Q54TR1", "DDB_G0281605", "P05095", "DDB_G0268632", "Q54V78", "DDB_G0280565", "Q55FR5", "DDB_G0267990", "P52922", "DDB_G0269148", "Q54JM9", "DDB_G0287939", "Q23919", "DDB_G0288483", "Q54RX2", "DDB_G0282859", "Q54HL4", "DDB_G0289365", "Q86A67", "DDB_G0274375", "Q55D97", "DDB_G0270626", "Q54I82", "DDB_G0288933", "Q5R1U3", "DDB_G0277001", "O76856", "DDB_G0279411", "B0G198", "DDB_G0295683" ] }, "reaction_10612848": { "compartment": "compartment_21994", "id": "reaction_10612848", "reactome": "R-DDI-6789031", "name": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1222719", "species_6788973", "species_1470067" ], "products": [ "species_1222475", "species_6789150" ], "modifiers": [ [ "species_10612845", "catalyst" ] ], "additional_components": [ "Q6TMK4", "DDB_G0277275", "CHEBI:55376" ] }, "reaction_10612851": { "compartment": "compartment_1222282", "id": "reaction_10612851", "reactome": "R-DDI-6789126", "name": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1222719", "species_6788973", "species_1470067" ], "products": [ "species_1222475", "species_6789150" ], "modifiers": [ [ "species_10612843", "catalyst" ] ], "additional_components": [ "Q6TMK4", "DDB_G0277275", "CHEBI:55376" ] }, "reaction_10612853": { "compartment": "compartment_21994", "id": "reaction_10612853", "reactome": "R-DDI-6789136", "name": "Myeloperoxidase (MPO) binds to the bacterial cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612843", "species_983438" ], "products": [ "species_10612845" ], "modifiers": [], "additional_components": [ "Q6TMK4", "DDB_G0277275", "CHEBI:55376", "Q6TMK4", "DDB_G0277275", "CHEBI:55376" ] }, "reaction_10622909": { "compartment": "compartment_1222282", "id": "reaction_10622909", "reactome": "R-DDI-8933635", "name": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1222719", "species_1470067", "species_6789221" ], "products": [ "species_8933637", "species_1222475" ], "modifiers": [ [ "species_10612843", "catalyst" ] ], "additional_components": [ "Q6TMK4", "DDB_G0277275", "CHEBI:55376" ] }, "reaction_10619501": { "compartment": "compartment_984", "id": "reaction_10619501", "reactome": "R-DDI-8855490", "name": "Lactoperoxidase (LPO) produces OSCN-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351629", "species_8855492" ], "products": [ "species_109276", "species_8855489" ], "modifiers": [ [ "species_10619498", "catalyst" ] ], "additional_components": [ "Q6TMK4", "DDB_G0277275", "CHEBI:55376" ] }, "reaction_10597227": { "compartment": "compartment_1222693", "id": "reaction_10597227", "reactome": "R-DDI-1222516", "name": "Intraphagosomal pH is lowered to 5 by V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106" ], "products": [ "species_1470067" ], "modifiers": [ [ "species_10597224", "catalyst" ] ], "additional_components": [ "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q55AH5", "DDB_G0271882", "Q86A77", "DDB_G0274331", "O00780", "DDB_G0275701", "Q54Z13", "DDB_G0277971", "Q76NU1", "DDB_G0277401", "P54648", "DDB_G0284473", "Q54E04", "DDB_G0291858", "Q86AS7", "DDB_G0274141", "P54642", "DDB_G0274381", "P54641", "DDB_G0273071" ] }, "reaction_10593221": { "compartment": "compartment_70101", "id": "reaction_10593221", "reactome": "R-DDI-450400", "name": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593206", "species_450597", "species_10593217" ], "products": [ "species_10593219" ], "modifiers": [], "additional_components": [ "DDB_G0269948", "DDB_G0285973", "Q54MG5", "DDB_G0285973", "Q55CQ7", "DDB_G0269948" ] }, "reaction_10593230": { "compartment": "compartment_70101", "id": "reaction_10593230", "reactome": "R-DDI-450431", "name": "ZFP36 (TTP) recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593226", "species_10591881", "species_10591977", "species_10591874", "species_10593219" ], "products": [ "species_10593228" ], "modifiers": [], "additional_components": [ "DDB_G0289921", "DDB_G0283315", "Q55BJ2", "DDB_G0271100", "Q54VM4", "DDB_G0280251", "Q54CU6", "DDB_G0292692", "Q55BB0", "DDB_G0271396", "Q54EU6", "DDB_G0291328", "Q54Q83", "DDB_G0284053", "Q54EV5", "DDB_G0291310", "Q54N99", "DDB_G0285377", "Q54BH9", "DDB_G0293614", "Q7KWX9", "DDB_G0276783", "DDB_G0287243", "Q54MG5", "DDB_G0285973", "Q55CQ7", "DDB_G0269948", "Q54MG5", "DDB_G0285973", "Q55CQ7", "DDB_G0269948", "Q54KM1", "DDB_G0287243", "Q55BJ2", "DDB_G0271100", "Q54VM4", "DDB_G0280251", "Q54CU6", "DDB_G0292692", "Q55BB0", "DDB_G0271396", "Q54EU6", "DDB_G0291328", "Q54Q83", "DDB_G0284053", "Q54EV5", "DDB_G0291310", "Q54N99", "DDB_G0285377", "Q54BH9", "DDB_G0293614", "Q7KWX9", "DDB_G0276783", "Q54R87", "DDB_G0283315", "Q54GU2", "DDB_G0289921" ] }, "reaction_10602772": { "compartment": "compartment_70101", "id": "reaction_10602772", "reactome": "R-DDI-3371435", "name": "Constitutive phosphorylation by GSK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10602761" ], "products": [ "species_10602764", "species_29370" ], "modifiers": [ [ "species_10602769", "catalyst" ] ], "additional_components": [ "DDB_G0281165", "DDB_G0281165", "DDB_G0272110" ] }, "reaction_10602840": { "compartment": "compartment_7660", "id": "reaction_10602840", "reactome": "R-DDI-3371567", "name": "DBC1 is phosphorylated by ATM/ART", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10602832" ], "products": [ "species_113582", "species_10602826" ], "modifiers": [ [ "species_10602837", "catalyst" ] ], "additional_components": [ "DDB_G0274577", "DDB_G0274577", "DDB_G0291380" ] }, "reaction_10602830": { "compartment": "compartment_7660", "id": "reaction_10602830", "reactome": "R-DDI-3371537", "name": "DBC1 binds SIRT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602826", "species_10591478" ], "products": [ "species_10602828" ], "modifiers": [], "additional_components": [ "DDB_G0274577", "DDB_G0289967", "Q54GV7", "DDB_G0289967", "Q86A78", "DDB_G0274577" ] }, "reaction_10602865": { "compartment": "compartment_70101", "id": "reaction_10602865", "reactome": "R-DDI-3371591", "name": "Trimerization of cytosolic HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602761" ], "products": [ "species_10602814" ], "modifiers": [ [ "species_10583736", "catalyst" ] ], "additional_components": [ "DDB_G0281165", "Q54UC1", "DDB_G0281165", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136" ] }, "reaction_10605045": { "compartment": "compartment_70101", "id": "reaction_10605045", "reactome": "R-DDI-5324632", "name": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5324631", "species_10605040" ], "products": [ "species_10602761", "species_10589012", "species_10605042", "species_10602802" ], "modifiers": [ [ "species_10605040", "catalyst" ] ], "additional_components": [ "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "Q54UC1", "DDB_G0281165", "Q54X15", "DDB_G0279267", "P90532", "DDB_G0288065", "DDB_G0281165", "DDB_G0268042", "Q54X15", "DDB_G0279267", "P90532", "DDB_G0288065", "P54651", "DDB_G0267400", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "Q54UC1", "DDB_G0281165", "Q54X15", "DDB_G0279267", "P90532", "DDB_G0288065" ] }, "reaction_10602820": { "compartment": "compartment_70101", "id": "reaction_10602820", "reactome": "R-DDI-3371527", "name": "HSF1 trimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602814" ], "products": [ "species_10602818" ], "modifiers": [], "additional_components": [ "Q54UC1", "DDB_G0281165", "Q54UC1", "DDB_G0281165" ] }, "reaction_10602857": { "compartment": "compartment_70101", "id": "reaction_10602857", "reactome": "R-DDI-3371586", "name": "Dissociation of cytosolic HSF1:HSP90 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602855" ], "products": [ "species_10602761", "species_10589012", "species_10602802" ], "modifiers": [], "additional_components": [ "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "Q54UC1", "DDB_G0281165", "DDB_G0281165", "DDB_G0268042", "P54651", "DDB_G0267400" ] }, "reaction_10604376": { "compartment": "compartment_7660", "id": "reaction_10604376", "reactome": "R-DDI-5082409", "name": "Dissociation of HSF1:HSP90 complex in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604374" ], "products": [ "species_10604366", "species_10604347", "species_10604372" ], "modifiers": [], "additional_components": [ "P54651", "DDB_G0267400", "Q54UC1", "DDB_G0281165", "Q55FM3", "DDB_G0268042", "DDB_G0268042", "DDB_G0281165", "P54651", "DDB_G0267400" ] }, "reaction_10604349": { "compartment": "compartment_7660", "id": "reaction_10604349", "reactome": "R-DDI-5082391", "name": "Trimerization of HSF1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604347" ], "products": [ "species_10602818" ], "modifiers": [], "additional_components": [ "DDB_G0281165", "Q54UC1", "DDB_G0281165" ] }, "reaction_10582483": { "compartment": "compartment_7660", "id": "reaction_10582483", "reactome": "R-DDI-77590", "name": "Recruitment of CstF to the CPSF Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582477", "species_10579555" ], "products": [ "species_10582481" ], "modifiers": [], "additional_components": [ "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q55BS1", "DDB_G0270392", "Q55CA3", "DDB_G0270148", "Q54PX4", "DDB_G0284319", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797", "C7G084", "DDB_G0295793", "Q54TS6", "DDB_G0281585", "Q54V94", "DDB_G0280529", "Q54XS9", "DDB_G0278769", "Q54LG7", "DDB_G0286645", "Q54V94", "DDB_G0280529", "Q54XS9", "DDB_G0278769", "Q54LG7", "DDB_G0286645", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q55BS1", "DDB_G0270392", "Q55CA3", "DDB_G0270148", "Q54PX4", "DDB_G0284319", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797", "C7G084", "DDB_G0295793", "Q54TS6", "DDB_G0281585" ] }, "reaction_10582479": { "compartment": "compartment_7660", "id": "reaction_10582479", "reactome": "R-DDI-77589", "name": "Recognition of AAUAAA sequence by CPSF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10579534", "species_10582475" ], "products": [ "species_10582477" ], "modifiers": [], "additional_components": [ "Q55BS1", "DDB_G0270392", "Q55CA3", "DDB_G0270148", "Q54PX4", "DDB_G0284319", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797", "C7G084", "DDB_G0295793", "Q54TS6", "DDB_G0281585", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q55BS1", "DDB_G0270392", "Q55CA3", "DDB_G0270148", "Q54PX4", "DDB_G0284319", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797", "C7G084", "DDB_G0295793", "Q54TS6", "DDB_G0281585" ] }, "reaction_10601473": { "compartment": "compartment_70101", "id": "reaction_10601473", "reactome": "R-DDI-2586748", "name": "GUCA binds Ca2+ to form GUCA:Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581368", "species_74016" ], "products": [ "species_10581380" ], "modifiers": [], "additional_components": [ "DDB_G0275931", "species_74112", "Q75K28", "DDB_G0275931" ] }, "reaction_10601385": { "compartment": "compartment_70101", "id": "reaction_10601385", "reactome": "R-DDI-2534087", "name": "NMT1/2 transfer MYS to GNAT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601375", "species_2534019" ], "products": [ "species_10581129", "species_76194" ], "modifiers": [ [ "species_10601380", "catalyst" ] ], "additional_components": [ "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "Q54VG1", "DDB_G0280351", "P16051", "DDB_G0276267", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "DDB_G0275863" ] }, "reaction_10601432": { "compartment": "compartment_70101", "id": "reaction_10601432", "reactome": "R-DDI-2534096", "name": "METAP1/2 demethylates GNAT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601413" ], "products": [ "species_10601375", "species_174390" ], "modifiers": [ [ "species_10601429", "catalyst" ] ], "additional_components": [ "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "Q55C21", "DDB_G0270264", "species_880069", "Q54WU3", "DDB_G0279433" ] }, "reaction_10581390": { "compartment": "compartment_2514888", "id": "reaction_10581390", "reactome": "R-DDI-74885", "name": "GUCYs converts GTP to cGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438" ], "products": [ "species_111294", "species_30991" ], "modifiers": [ [ "species_10581362", "catalyst" ], [ "species_10581382", "catalyst" ], [ "species_10581384", "catalyst" ], [ "species_10581380", "inhibitor" ], [ "species_10581386", "inhibitor" ], [ "species_10581388", "inhibitor" ] ], "additional_components": [ "Q03101", "DDB_G0274569", "Q553Y7", "DDB_G0275009", "DDB_G0275931", "DDB_G0275931", "species_74112", "Q75K28", "DDB_G0275931", "species_74112", "Q75K28", "DDB_G0275931", "species_74112", "Q75K28", "DDB_G0275931" ] }, "reaction_10591906": { "compartment": "compartment_70101", "id": "reaction_10591906", "reactome": "R-DDI-429978", "name": "Lsm1-7 Complex binds deadenylated mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10591863", "species_429974" ], "products": [ "species_10591865" ], "modifiers": [], "additional_components": [ "Q54HF6", "DDB_G0289499", "Q55F60", "DDB_G0268244", "Q54W83", "DDB_G0279837", "Q1ZXK3", "DDB_G0277107", "Q54KX4", "DDB_G0287053", "Q55EX5", "DDB_G0268716", "Q552U1", "DDB_G0275719", "Q54TF6", "DDB_G0281779", "Q54HF6", "DDB_G0289499", "Q55F60", "DDB_G0268244", "Q54W83", "DDB_G0279837", "Q1ZXK3", "DDB_G0277107", "Q54KX4", "DDB_G0287053", "Q55EX5", "DDB_G0268716", "Q552U1", "DDB_G0275719", "Q54TF6", "DDB_G0281779" ] }, "reaction_10591896": { "compartment": "compartment_70101", "id": "reaction_10591896", "reactome": "R-DDI-429860", "name": "DCP1-DCP2 complex decaps mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10591865" ], "products": [ "species_10591867", "species_430004" ], "modifiers": [ [ "species_10591893", "catalyst" ] ], "additional_components": [ "Q54HF6", "DDB_G0289499", "Q55F60", "DDB_G0268244", "Q54W83", "DDB_G0279837", "Q1ZXK3", "DDB_G0277107", "Q54KX4", "DDB_G0287053", "Q55EX5", "DDB_G0268716", "Q552U1", "DDB_G0275719", "Q54TF6", "DDB_G0281779", "Q54HF6", "DDB_G0289499", "Q55F60", "DDB_G0268244", "Q54W83", "DDB_G0279837", "Q1ZXK3", "DDB_G0277107", "Q54KX4", "DDB_G0287053", "Q55EX5", "DDB_G0268716", "Q552U1", "DDB_G0275719", "Q54TF6", "DDB_G0281779", "Q54E49", "DDB_G0291804", "Q54KM1", "DDB_G0287243", "Q54R87", "DDB_G0283315", "Q54J96", "DDB_G0288241" ] }, "reaction_10589052": { "compartment": "compartment_984", "id": "reaction_10589052", "reactome": "R-DDI-265456", "name": "NPC1L1 inactivation by ezetimibe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589048", "species_265479" ], "products": [ "species_10589050" ], "modifiers": [], "additional_components": [ "Q551C5", "DDB_G0276657", "Q9TVK6", "DDB_G0269158", "species_265479", "Q551C5", "DDB_G0276657", "Q9TVK6", "DDB_G0269158" ] }, "reaction_10619411": { "compartment": "compartment_17938", "id": "reaction_10619411", "reactome": "R-DDI-8854329", "name": "TBC1D15 accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10619394" ], "products": [ "species_29372", "species_10619396" ], "modifiers": [ [ "species_10619394", "catalyst" ], [ "species_10619409", "catalyst" ] ], "additional_components": [ "species_29438", "P36411", "DDB_G0269236", "Q54FK4", "DDB_G0290833", "Q54FK2", "DDB_G0290793", "Q54FK7", "DDB_G0290779", "Q54FK5", "DDB_G0290789", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "Q54FK8", "DDB_G0290829", "Q1ZXB9", "DDB_G0290831", "Q1ZXB8", "DDB_G0294571", "Q552H0", "DDB_G0294571", "P36411", "DDB_G0269236", "Q54FK4", "DDB_G0290833", "Q54FK2", "DDB_G0290793", "Q54FK7", "DDB_G0290779", "Q54FK5", "DDB_G0290789", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "Q54FK8", "DDB_G0290829", "Q1ZXB9", "DDB_G0290831", "Q1ZXB8", "DDB_G0294571", "Q552H0", "DDB_G0294571", "species_29420", "species_29438", "P36411", "DDB_G0269236", "Q54FK4", "DDB_G0290833", "Q54FK2", "DDB_G0290793", "Q54FK7", "DDB_G0290779", "Q54FK5", "DDB_G0290789", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "Q54FK8", "DDB_G0290829", "Q1ZXB9", "DDB_G0290831", "Q1ZXB8", "DDB_G0294571", "Q552H0", "DDB_G0294571", "Q54IE1", "DDB_G0288811", "Q54UD8", "DDB_G0288811" ] }, "reaction_10619424": { "compartment": "compartment_5683628", "id": "reaction_10619424", "reactome": "R-DDI-8854588", "name": "TBC1D25 (OATL1) binds ATG8 homologues", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619420", "species_10619414" ], "products": [ "species_10619422" ], "modifiers": [], "additional_components": [ "Q54UD8", "DDB_G0288811", "Q54IE1", "DDB_G0288811", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q54UD8", "DDB_G0288811", "Q54IE1", "DDB_G0288811" ] }, "reaction_10619313": { "compartment": "compartment_19363", "id": "reaction_10619313", "reactome": "R-DDI-8854209", "name": "TBC1D10A binds JFC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619309", "species_10619303" ], "products": [ "species_10619311" ], "modifiers": [], "additional_components": [ "Q54Z16", "DDB_G0289735", "Q54H32", "DDB_G0289735", "DDB_G0282977", "Q54RR0", "DDB_G0282977", "Q54Z16", "DDB_G0289735", "Q54H32", "DDB_G0289735" ] }, "reaction_10619441": { "compartment": "compartment_437051", "id": "reaction_10619441", "reactome": "R-DDI-8854604", "name": "TBC1D16 accelerates GTP hydrolysis by RAB4A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10619430" ], "products": [ "species_29372", "species_10619432" ], "modifiers": [ [ "species_10619430", "catalyst" ], [ "species_10619439", "catalyst" ] ], "additional_components": [ "Q54DA7", "DDB_G0292406", "species_29438", "Q54DA7", "DDB_G0292406", "species_29420", "Q54DA7", "DDB_G0292406", "species_29438", "Q54IE1", "DDB_G0288811", "Q54UD8", "DDB_G0288811" ] }, "reaction_10619366": { "compartment": "compartment_20699", "id": "reaction_10619366", "reactome": "R-DDI-8854303", "name": "TBC1D11 binds RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618515", "species_10619362" ], "products": [ "species_10619364" ], "modifiers": [], "additional_components": [ "Q55FK2", "DDB_G0268068", "species_29438", "DDB_G0290597", "Q54FT8", "DDB_G0290597", "Q55FK2", "DDB_G0268068", "species_29438" ] }, "reaction_10619478": { "compartment": "compartment_262783", "id": "reaction_10619478", "reactome": "R-DDI-8854759", "name": "TBC1D14 binds RAB11 and ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619469", "species_10619467", "species_10619474" ], "products": [ "species_10619476" ], "modifiers": [], "additional_components": [ "DDB_G0292390", "P36412", "DDB_G0269238", "Q86JP0", "DDB_G0294583", "DDB_G0269130", "O96904", "DDB_G0269130", "P36412", "DDB_G0269238", "Q86JP0", "DDB_G0294583", "Q86CS2", "DDB_G0292390" ] }, "reaction_10619300": { "compartment": "compartment_24339", "id": "reaction_10619300", "reactome": "R-DDI-8854173", "name": "TBC RabGAPs accelerate GTP hydrolysis by RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10619265" ], "products": [ "species_29372", "species_10619267" ], "modifiers": [ [ "species_10619265", "catalyst" ], [ "species_10619298", "catalyst" ] ], "additional_components": [ "Q54FL2", "DDB_G0290783", "species_29438", "species_29420", "Q54FL2", "DDB_G0290783", "Q54FL2", "DDB_G0290783", "species_29438", "Q54Z16", "DDB_G0289735", "Q54H32", "DDB_G0289735", "Q54CG7", "DDB_G0292932", "Q55F14", "DDB_G0269052" ] }, "reaction_10619352": { "compartment": "compartment_262783", "id": "reaction_10619352", "reactome": "R-DDI-8854293", "name": "TBC1D10A (EPI64) binds ARF6:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619309", "species_10619348" ], "products": [ "species_10619350" ], "modifiers": [], "additional_components": [ "Q54Z16", "DDB_G0289735", "Q54H32", "DDB_G0289735", "Q554Y8", "DDB_G0274445", "species_29438", "Q554Y8", "DDB_G0274445", "species_29438", "Q54Z16", "DDB_G0289735", "Q54H32", "DDB_G0289735" ] }, "reaction_10619340": { "compartment": "compartment_17938", "id": "reaction_10619340", "reactome": "R-DDI-8854255", "name": "TBC1D2A accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10619323" ], "products": [ "species_10619325", "species_29372" ], "modifiers": [ [ "species_10619323", "catalyst" ], [ "species_10619338", "catalyst" ] ], "additional_components": [ "species_29438", "P36411", "DDB_G0269236", "P36411", "DDB_G0269236", "species_29420", "species_29438", "P36411", "DDB_G0269236", "Q553Q2", "DDB_G0295717", "C7G032", "DDB_G0295717", "Q55E78", "DDB_G0295717", "Q553U1", "DDB_G0295717", "Q75JG4", "DDB_G0276119" ] }, "reaction_10619453": { "compartment": "compartment_5683628", "id": "reaction_10619453", "reactome": "R-DDI-8854612", "name": "TBC1D25 accelerates GTP hydrolysis by RAB33B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10619448" ], "products": [ "species_29372", "species_10619450" ], "modifiers": [ [ "species_10619448", "catalyst" ], [ "species_10619420", "catalyst" ] ], "additional_components": [ "O76173", "DDB_G0269174", "species_29438", "O76173", "DDB_G0269174", "species_29420", "O76173", "DDB_G0269174", "species_29438", "Q54UD8", "DDB_G0288811", "Q54IE1", "DDB_G0288811" ] }, "reaction_10594836": { "compartment": "compartment_70101", "id": "reaction_10594836", "reactome": "R-DDI-917696", "name": "Cargo Sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594815", "species_10594832" ], "products": [ "species_10594813", "species_10594834" ], "modifiers": [], "additional_components": [ "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P14797", "DDB_G0276765", "species_179838", "Q55DV8", "DDB_G0269510", "Q54NF1", "DDB_G0285295", "Q54LJ3", "DDB_G0286797", "Q54RC4", "DDB_G0283203", "Q55GD9", "DDB_G0267708", "Q54T18", "DDB_G0282045", "Q55DV8", "DDB_G0269510", "Q54NF1", "DDB_G0285295", "Q54LJ3", "DDB_G0286797", "Q54RC4", "DDB_G0283203", "Q55GD9", "DDB_G0267708", "Q54T18", "DDB_G0282045", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P14797", "DDB_G0276765", "species_179838" ] }, "reaction_10594788": { "compartment": "compartment_74700", "id": "reaction_10594788", "reactome": "R-DDI-917693", "name": "ESCRT Disassembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10594631" ], "products": [ "species_29372", "species_10594475", "species_29370", "species_10594489", "species_10594470", "species_10594484", "species_10594769", "species_10594465" ], "modifiers": [ [ "species_10594785", "catalyst" ] ], "additional_components": [ "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P14797", "DDB_G0276765", "species_179838", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54P63", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q86H98", "DDB_G0275573", "DDB_G0275573", "DDB_G0287993", "DDB_G0284769", "DDB_G0287021", "species_179838", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0290087", "Q54PT2", "DDB_G0284347", "Q54JK4", "DDB_G0287993", "Q55B11", "DDB_G0271488" ] }, "reaction_10594838": { "compartment": "compartment_70101", "id": "reaction_10594838", "reactome": "R-DDI-917700", "name": "MVB Vesicle Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594491", "species_10594834" ], "products": [ "species_10594631", "species_10594832" ], "modifiers": [], "additional_components": [ "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54P63", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q86H98", "DDB_G0275573", "Q54RC4", "DDB_G0283203", "Q55GD9", "DDB_G0267708", "Q54T18", "DDB_G0282045", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P14797", "DDB_G0276765", "species_179838", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P14797", "DDB_G0276765", "species_179838", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54P63", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q86H98", "DDB_G0275573", "Q54RC4", "DDB_G0283203", "Q55GD9", "DDB_G0267708", "Q54T18", "DDB_G0282045" ] }, "reaction_10611220": { "compartment": "compartment_70101", "id": "reaction_10611220", "reactome": "R-DDI-5691131", "name": "CANDI binds CUL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585421", "species_10611216" ], "products": [ "species_10611218" ], "modifiers": [], "additional_components": [ "DDB_G0291972", "DDB_G0274167", "Q86KD1", "DDB_G0274167", "O60999", "DDB_G0291972" ] }, "reaction_10611211": { "compartment": "compartment_70101", "id": "reaction_10611211", "reactome": "R-DDI-5691108", "name": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611084", "species_10577037" ], "products": [ "species_10611202" ], "modifiers": [ [ "species_10611208", "catalyst" ] ], "additional_components": [ "DDB_G0279159", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0279159", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54XV3", "DDB_G0278711" ] }, "reaction_10611082": { "compartment": "compartment_70101", "id": "reaction_10611082", "reactome": "R-DDI-5690873", "name": "ACO1 binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690881", "species_10611078" ], "products": [ "species_10611080" ], "modifiers": [], "additional_components": [ "DDB_G0279159", "Q54X73", "DDB_G0279159" ] }, "reaction_10594848": { "compartment": "compartment_74700", "id": "reaction_10594848", "reactome": "R-DDI-917936", "name": "MCOLN1 transports Fe2+ from endosome lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_917810" ], "products": [ "species_71067" ], "modifiers": [ [ "species_10594845", "catalyst" ] ], "additional_components": [ "DDB_G0291275" ] }, "reaction_10594840": { "compartment": "compartment_74700", "id": "reaction_10594840", "reactome": "R-DDI-917841", "name": "Acidification of Tf:TfR1 containing endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_70106", "species_113592" ], "products": [ "species_29372", "species_29370", "species_74722" ], "modifiers": [ [ "species_10581339", "catalyst" ] ], "additional_components": [ "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q55AH5", "DDB_G0271882", "Q86A77", "DDB_G0274331", "O00780", "DDB_G0275701", "Q54Z13", "DDB_G0277971", "Q76NU1", "DDB_G0277401", "P54648", "DDB_G0284473", "P54641", "DDB_G0273071", "Q86AS7", "DDB_G0274141", "Q54E04", "DDB_G0291858", "P54642", "DDB_G0274381", "Q557I5", "DDB_G0273483" ] }, "reaction_10611087": { "compartment": "compartment_70101", "id": "reaction_10611087", "reactome": "R-DDI-5690911", "name": "ACO1:4Fe-4S isomerises CIT to ISCIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76190" ], "products": [ "species_389545" ], "modifiers": [ [ "species_10611080", "catalyst" ] ], "additional_components": [ "Q54X73", "DDB_G0279159" ] } }, "motif_reaction_dictionary": { "reaction_10584068": { "compartment": "compartment_7660", "id": "reaction_10584068", "reactome": "R-DDI-163733", "name": "Transcriptional activation of FAS monomer gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10581670" ], "modifiers": [], "additional_components": [ "Q869X2", "DDB_G0275077", "Q55E72", "DDB_G0269364", "Q869W9", "DDB_G0275069" ] }, "reaction_10584072": { "compartment": "compartment_7660", "id": "reaction_10584072", "reactome": "R-DDI-163743", "name": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10584070" ], "modifiers": [], "additional_components": [ "DDB_G0288387" ] }, "reaction_10584074": { "compartment": "compartment_7660", "id": "reaction_10584074", "reactome": "R-DDI-163748", "name": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10581684" ], "modifiers": [], "additional_components": [ "DDB_G0291332" ] }, "reaction_10601278": { "compartment": "compartment_984", "id": "reaction_10601278", "reactome": "R-DDI-2514772", "name": "Fibrillin-1 degradation by MMP3, CTSK, CTSL2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600215" ], "products": [ "species_10601195" ], "modifiers": [ [ "species_10601275", "catalyst" ] ], "additional_components": [ "Q54IA3", "DDB_G0295485", "B0G154", "DDB_G0295485", "Q54IA3", "DDB_G0295485", "B0G154", "DDB_G0295485", "Q54TR1", "DDB_G0281605", "Q54UH2", "DDB_G0282991", "Q54UH3", "DDB_G0282991", "Q86KD4", "DDB_G0282991", "P04989", "DDB_G0279799", "Q23894", "DDB_G0283867", "Q54RQ2", "DDB_G0282991" ] }, "reaction_10603294": { "compartment": "compartment_984", "id": "reaction_10603294", "reactome": "R-DDI-3814820", "name": "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598295" ], "products": [ "species_10603257", "species_10603255" ], "modifiers": [ [ "species_10603291", "catalyst" ] ], "additional_components": [ "DDB_G0270488", "DDB_G0270488", "DDB_G0270488", "Q54TR1", "DDB_G0281605", "Q54UH2", "DDB_G0282991", "Q54UH3", "DDB_G0282991", "Q86KD4", "DDB_G0282991", "P04989", "DDB_G0279799", "Q23894", "DDB_G0283867", "Q54RQ2", "DDB_G0282991" ] }, "reaction_10594336": { "compartment": "compartment_13231", "id": "reaction_10594336", "reactome": "R-DDI-913529", "name": "Translocation of p-STAT1:p-STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594322" ], "products": [ "species_10594334" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167" ] }, "reaction_10597154": { "compartment": "compartment_70101", "id": "reaction_10597154", "reactome": "R-DDI-1169397", "name": "Activation of ISG15 by UBA7 E1 ligase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10595036", "species_113592", "species_10595029" ], "products": [ "species_111294", "species_10597151", "species_76577" ], "modifiers": [ [ "species_10595036", "catalyst" ] ], "additional_components": [ "DDB_G0270272", "DDB_G0292984", "Q54CI1", "DDB_G0292984", "Q55C16", "DDB_G0270272", "DDB_G0270272" ] }, "reaction_10597170": { "compartment": "compartment_70101", "id": "reaction_10597170", "reactome": "R-DDI-1169404", "name": "Transfer of ISG15 from E1 to E2 (UBCH8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597151", "species_10595031" ], "products": [ "species_10595036", "species_10597143" ], "modifiers": [ [ "species_10595031", "catalyst" ] ], "additional_components": [ "Q54CI1", "DDB_G0292984", "Q55C16", "DDB_G0270272", "DDB_G0281833", "DDB_G0270272", "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "DDB_G0281833" ] }, "reaction_10597158": { "compartment": "compartment_70101", "id": "reaction_10597158", "reactome": "R-DDI-1169399", "name": "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596135", "species_10595029" ], "products": [ "species_10597156" ], "modifiers": [], "additional_components": [ "C7G034", "DDB_G0285063", "Q54QF1", "DDB_G0283983", "DDB_G0292984", "Q54CI1", "DDB_G0292984", "C7G034", "DDB_G0285063", "Q54QF1", "DDB_G0283983" ] }, "reaction_10599224": { "compartment": "compartment_70101", "id": "reaction_10599224", "reactome": "R-DDI-1678842", "name": "Competitive inhibition of translation initiation by ISGylated 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599208", "species_10599220" ], "products": [ "species_10599222", "species_10599218" ], "modifiers": [], "additional_components": [ "B0G0Z1", "DDB_G0284841", "Q54E38", "DDB_G0291820", "Q55BQ5", "DDB_G0284841", "Q54P37", "DDB_G0284841", "Q54T63", "DDB_G0284841", "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043", "Q55FE0", "DDB_G0268574", "Q54E38", "DDB_G0291820", "Q553R3", "DDB_G0275395", "Q55D61", "DDB_G0269192", "P90529", "DDB_G0269146", "B0G0Z1", "DDB_G0284841", "Q54E38", "DDB_G0291820", "Q55BQ5", "DDB_G0284841", "Q54P37", "DDB_G0284841", "Q54T63", "DDB_G0284841", "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043", "Q55FE0", "DDB_G0268574", "Q54E38", "DDB_G0291820", "Q553R3", "DDB_G0275395", "Q55D61", "DDB_G0269192", "P90529", "DDB_G0269146" ] }, "reaction_10597192": { "compartment": "compartment_70101", "id": "reaction_10597192", "reactome": "R-DDI-1169406", "name": "ISGylation of host proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597149", "species_113592", "species_10597188" ], "products": [ "species_111294", "species_10597147", "species_10597190", "species_10595031", "species_76577" ], "modifiers": [ [ "species_10597149", "catalyst" ] ], "additional_components": [ "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q54TE1", "DDB_G0281833", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043", "Q54CI1", "DDB_G0292984", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q54TE1", "DDB_G0281833", "DDB_G0281833", "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043" ] }, "reaction_10599179": { "compartment": "compartment_70101", "id": "reaction_10599179", "reactome": "R-DDI-1678841", "name": "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597190" ], "products": [ "species_10597188", "species_141681" ], "modifiers": [ [ "species_10599176", "catalyst" ] ], "additional_components": [ "Q54CI1", "DDB_G0292984", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q54TE1", "DDB_G0281833", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q54TE1", "DDB_G0281833", "Q54DT4", "DDB_G0292046", "Q553T4", "DDB_G0275415" ] }, "reaction_10599226": { "compartment": "compartment_70101", "id": "reaction_10599226", "reactome": "R-DDI-1678843", "name": "ISGylation of protein translation regulator 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597149", "species_10599206" ], "products": [ "species_10599208" ], "modifiers": [], "additional_components": [ "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043", "B0G0Z1", "DDB_G0284841", "Q54E38", "DDB_G0291820", "Q55BQ5", "DDB_G0284841", "Q54P37", "DDB_G0284841", "Q54T63", "DDB_G0284841", "B0G0Z1", "DDB_G0284841", "Q54E38", "DDB_G0291820", "Q55BQ5", "DDB_G0284841", "Q54P37", "DDB_G0284841", "Q54T63", "DDB_G0284841", "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043" ] }, "reaction_10597165": { "compartment": "compartment_70101", "id": "reaction_10597165", "reactome": "R-DDI-1169402", "name": "ISGylation of E2 conjugating enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597149", "species_113592", "species_10597160" ], "products": [ "species_111294", "species_10597162", "species_10597147", "species_10595031", "species_76577" ], "modifiers": [ [ "species_10597149", "catalyst" ] ], "additional_components": [ "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043", "Q86K32", "DDB_G0277267", "Q54TE1", "DDB_G0281833", "Q54CI1", "DDB_G0292984", "Q86K32", "DDB_G0277267", "Q54TE1", "DDB_G0281833", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043", "DDB_G0281833", "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043" ] }, "reaction_10597167": { "compartment": "compartment_70101", "id": "reaction_10597167", "reactome": "R-DDI-1169403", "name": "Interaction of E3 ligase with ISG15:E2 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597147", "species_10597143" ], "products": [ "species_10597149" ], "modifiers": [], "additional_components": [ "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043", "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54I29", "DDB_G0289043" ] }, "reaction_10594178": { "compartment": "compartment_13231", "id": "reaction_10594178", "reactome": "R-DDI-873917", "name": "Translocation of STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594164" ], "products": [ "species_10594176" ], "modifiers": [], "additional_components": [ "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167" ] }, "reaction_10594217": { "compartment": "compartment_7660", "id": "reaction_10594217", "reactome": "R-DDI-877281", "name": "PIAS1 binds p-STAT1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594201", "species_10594213", "species_10594176" ], "products": [ "species_10594215" ], "modifiers": [], "additional_components": [ "Q54V57", "DDB_G0280603", "Q555X5", "DDB_G0274743", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q54V57", "DDB_G0280603", "Q555X5", "DDB_G0274743" ] }, "reaction_10612656": { "compartment": "compartment_70101", "id": "reaction_10612656", "reactome": "R-DDI-6786293", "name": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612625" ], "products": [ "species_10612654" ], "modifiers": [], "additional_components": [ "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381" ] }, "reaction_10612627": { "compartment": "compartment_70101", "id": "reaction_10612627", "reactome": "R-DDI-6786097", "name": "p-Y705-STAT3, p-Y641-STAT6 dimerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612621" ], "products": [ "species_10612625" ], "modifiers": [], "additional_components": [ "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638" ] }, "reaction_10612900": { "compartment": "compartment_17957", "id": "reaction_10612900", "reactome": "R-DDI-6790038", "name": "Expression of HSP90B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10612898" ], "modifiers": [ [ "species_10597019", "catalyst" ] ], "additional_components": [ "DDB_G0280057", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381" ] }, "reaction_10612808": { "compartment": "compartment_70101", "id": "reaction_10612808", "reactome": "R-DDI-6788622", "name": "p-Y-STATs dimerize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612804" ], "products": [ "species_10612806" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167" ] }, "reaction_10612812": { "compartment": "compartment_70101", "id": "reaction_10612812", "reactome": "R-DDI-6788623", "name": "p-Y-STATs translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612806" ], "products": [ "species_10612810" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381" ] }, "reaction_10592978": { "compartment": "compartment_984", "id": "reaction_10592978", "reactome": "R-DDI-449117", "name": "TXLNA (IL14) binds syntaxin1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10592964", "species_10592962" ], "products": [ "species_10592966" ], "modifiers": [ [ "species_10592976", "inhibitor" ] ], "additional_components": [ "DDB_G0289379", "DDB_G0290231", "Q54GD1", "DDB_G0290231", "Q54HM5", "DDB_G0289379", "Q54HM5", "DDB_G0289379", "Q54QC8", "DDB_G0283937", "Q54ZW8", "DDB_G0277343", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590" ] }, "reaction_10624948": { "compartment": "compartment_984", "id": "reaction_10624948", "reactome": "R-DDI-9014052", "name": "TXLNA (IL14) binds syntaxin3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10592962", "species_10624944" ], "products": [ "species_10624946" ], "modifiers": [], "additional_components": [ "DDB_G0290231", "Q55DR2", "DDB_G0270556", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556", "Q54HM5", "DDB_G0289379", "Q54GD1", "DDB_G0290231" ] }, "reaction_10624952": { "compartment": "compartment_984", "id": "reaction_10624952", "reactome": "R-DDI-9014074", "name": "TXLNA (IL14) binds syntaxin4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589716", "species_10592962" ], "products": [ "species_10624950" ], "modifiers": [], "additional_components": [ "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556", "DDB_G0290231", "Q54GD1", "DDB_G0290231", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556" ] }, "reaction_10593044": { "compartment": "compartment_70101", "id": "reaction_10593044", "reactome": "R-DDI-450296", "name": "Phosphorylated MKK3/MKK6 migrates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593036" ], "products": [ "species_10593042" ], "modifiers": [], "additional_components": [ "Q54HS0", "DDB_G0289277", "Q54HS0", "DDB_G0289277" ] }, "reaction_10593080": { "compartment": "compartment_70101", "id": "reaction_10593080", "reactome": "R-DDI-450346", "name": "activated human TAK1 phosphorylates MKK3/MKK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10593078" ], "products": [ "species_10593036", "species_29370" ], "modifiers": [ [ "species_10593069", "catalyst" ] ], "additional_components": [ "Q54HS0", "DDB_G0289277", "Q54HS0", "DDB_G0289277", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54FC5", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "P11467", "DDB_G0290961", "Q1ZXR0", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54LU8", "DDB_G0286465" ] }, "reaction_10587141": { "compartment": "compartment_7660", "id": "reaction_10587141", "reactome": "R-DDI-198746", "name": "ERK1/2/5 activate RSK1/2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10587082" ], "products": [ "species_113582", "species_10587136" ], "modifiers": [ [ "species_10587138", "catalyst" ] ], "additional_components": [ "Q8MYF1", "DDB_G0277449", "P34102", "DDB_G0286125", "P34102", "DDB_G0286125", "Q8MYF1", "DDB_G0277449", "P42525", "DDB_G0286353" ] }, "reaction_10587284": { "compartment": "compartment_7660", "id": "reaction_10587284", "reactome": "R-DDI-199959", "name": "ERKs are inactivated by protein phosphatase 2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10587138" ], "products": [ "species_113550", "species_10587274" ], "modifiers": [ [ "species_10587281", "catalyst" ] ], "additional_components": [ "P42525", "DDB_G0286353", "P42525", "DDB_G0286353", "Q54VB6", "DDB_G0280469" ] }, "reaction_10587820": { "compartment": "compartment_7660", "id": "reaction_10587820", "reactome": "R-DDI-203797", "name": "ERKs are inactivated by dual-specific phosphatases (DUSPs)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10587138" ], "products": [ "species_113550", "species_10587274" ], "modifiers": [ [ "species_10587817", "catalyst" ] ], "additional_components": [ "P42525", "DDB_G0286353", "P42525", "DDB_G0286353", "Q55BI8", "DDB_G0285449", "Q54N84", "DDB_G0285449", "Q54Y32", "DDB_G0278445", "Q556Y8", "DDB_G0285449" ] }, "reaction_10593072": { "compartment": "compartment_70101", "id": "reaction_10593072", "reactome": "R-DDI-450337", "name": "Activated TAK1 phosphorylates MKK4/MKK7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593050", "species_113592" ], "products": [ "species_29370", "species_10593060" ], "modifiers": [ [ "species_10593069", "catalyst" ] ], "additional_components": [ "Q54HS0", "DDB_G0289277", "Q54HS0", "DDB_G0289277", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54FC5", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "P11467", "DDB_G0290961", "Q1ZXR0", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54LU8", "DDB_G0286465" ] }, "reaction_10624354": { "compartment": "compartment_70101", "id": "reaction_10624354", "reactome": "R-DDI-8983373", "name": "p-Y-STAT3 binds p-STAT5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624350", "species_10624340" ], "products": [ "species_10624352" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167" ] }, "reaction_10624388": { "compartment": "compartment_70101", "id": "reaction_10624388", "reactome": "R-DDI-8983379", "name": "p-Y-STAT3:p-STAT5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624352" ], "products": [ "species_10624386" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "Q54BD4", "DDB_G0293532", "O00910", "DDB_G0281381", "Q86I20", "DDB_G0275167", "Q70GP4", "DDB_G0268638" ] }, "reaction_10624407": { "compartment": "compartment_70101", "id": "reaction_10624407", "reactome": "R-DDI-8985943", "name": "p-Y701-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624403" ], "products": [ "species_10624405" ], "modifiers": [], "additional_components": [ "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532" ] }, "reaction_10624411": { "compartment": "compartment_70101", "id": "reaction_10624411", "reactome": "R-DDI-8985950", "name": "p-Y649-STAT5A, p-STAT5B dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624340" ], "products": [ "species_10624409" ], "modifiers": [], "additional_components": [] }, "reaction_10624415": { "compartment": "compartment_70101", "id": "reaction_10624415", "reactome": "R-DDI-8985966", "name": "p-Y701-STAT1 binds p-Y705-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624350", "species_10624403" ], "products": [ "species_10624413" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532" ] }, "reaction_10624429": { "compartment": "compartment_70101", "id": "reaction_10624429", "reactome": "R-DDI-8985981", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624413" ], "products": [ "species_10624427" ], "modifiers": [], "additional_components": [ "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q54BD4", "DDB_G0293532", "O00910", "DDB_G0281381", "Q86I20", "DDB_G0275167", "Q70GP4", "DDB_G0268638" ] }, "reaction_10597005": { "compartment": "compartment_70101", "id": "reaction_10597005", "reactome": "R-DDI-1112538", "name": "Phosphorylated STAT1, STAT3 form dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596997" ], "products": [ "species_10597003" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167" ] }, "reaction_10597023": { "compartment": "compartment_70101", "id": "reaction_10597023", "reactome": "R-DDI-1112587", "name": "STAT1 and STAT3 dimers translocate to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597003" ], "products": [ "species_10597021" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381" ] }, "reaction_10624538": { "compartment": "compartment_70101", "id": "reaction_10624538", "reactome": "R-DDI-9009072", "name": "STAT3 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10589922" ], "products": [ "species_10624350", "species_29370" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q86I20", "DDB_G0275167", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167" ] }, "reaction_10593345": { "compartment": "compartment_70101", "id": "reaction_10593345", "reactome": "R-DDI-451418", "name": "Pellino ubiquitinates IRAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593334" ], "products": [ "species_10593342" ], "modifiers": [ [ "species_10593334", "catalyst" ] ], "additional_components": [ "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54D06", "DDB_G0292596", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54LU8", "DDB_G0286465", "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54D06", "DDB_G0292596" ] }, "reaction_10593026": { "compartment": "compartment_70101", "id": "reaction_10593026", "reactome": "R-DDI-450173", "name": "IRAK1 induces oligomerisation of TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10592841", "species_10584497" ], "products": [ "species_10592843" ], "modifiers": [], "additional_components": [ "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54LU8", "DDB_G0286465" ] }, "reaction_10623333": { "compartment": "compartment_70101", "id": "reaction_10623333", "reactome": "R-DDI-8948015", "name": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10592847" ], "products": [ "species_10592919" ], "modifiers": [ [ "species_10592847", "catalyst" ] ], "additional_components": [ "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54D06", "DDB_G0292596", "Q54FC5", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "P11467", "DDB_G0290961", "Q1ZXR0", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54D06", "DDB_G0292596" ] }, "reaction_10623337": { "compartment": "compartment_70101", "id": "reaction_10623337", "reactome": "R-DDI-8948018", "name": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10592919" ], "products": [ "species_10587623", "species_10623335" ], "modifiers": [], "additional_components": [ "Q54FC5", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "P11467", "DDB_G0290961", "Q1ZXR0", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54FC5", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "P11467", "DDB_G0290961", "Q1ZXR0", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54LU8", "DDB_G0286465" ] }, "reaction_10593870": { "compartment": "compartment_70101", "id": "reaction_10593870", "reactome": "R-DDI-507719", "name": "p62:MEKK3 binds to TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593866", "species_10584497" ], "products": [ "species_10593868" ], "modifiers": [], "additional_components": [ "Q55CE3", "DDB_G0270098", "Q54PX0", "DDB_G0284251", "Q55CA6", "DDB_G0284251", "Q8T2I8", "DDB_G0276465", "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q55CE3", "DDB_G0270098", "Q54PX0", "DDB_G0284251", "Q55CA6", "DDB_G0284251", "Q8T2I8", "DDB_G0276465" ] }, "reaction_10619777": { "compartment": "compartment_7660", "id": "reaction_10619777", "reactome": "R-DDI-8865605", "name": "BRWD1 binds SMARCA4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619773", "species_10602136" ], "products": [ "species_10619775" ], "modifiers": [], "additional_components": [ "DDB_G0285837", "DDB_G0271052", "Q55C32", "DDB_G0271052", "Q54MP8", "DDB_G0285837" ] }, "reaction_10619802": { "compartment": "compartment_7660", "id": "reaction_10619802", "reactome": "R-DDI-8865613", "name": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619773", "species_10619780" ], "products": [ "species_10619800" ], "modifiers": [], "additional_components": [ "DDB_G0285837", "DDB_G0291185", "Q54F38", "DDB_G0291185", "Q54MP8", "DDB_G0285837" ] }, "reaction_10623473": { "compartment": "compartment_70101", "id": "reaction_10623473", "reactome": "R-DDI-8950724", "name": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623469" ], "products": [ "species_10623471" ], "modifiers": [], "additional_components": [ "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381" ] }, "reaction_10623479": { "compartment": "compartment_70101", "id": "reaction_10623479", "reactome": "R-DDI-8950780", "name": "p-Y705-STAT3 binds p-Y693-STAT4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623421", "species_10596995" ], "products": [ "species_10623469" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638" ] }, "reaction_10623467": { "compartment": "compartment_70101", "id": "reaction_10623467", "reactome": "R-DDI-8950522", "name": "p-STAT1:p-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623463" ], "products": [ "species_10623465" ], "modifiers": [], "additional_components": [ "Q86I20", "DDB_G0275167", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "O00910", "DDB_G0281381", "Q86I20", "DDB_G0275167", "Q70GP4", "DDB_G0268638" ] }, "reaction_10623475": { "compartment": "compartment_70101", "id": "reaction_10623475", "reactome": "R-DDI-8950733", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597001" ], "products": [ "species_10597017" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381" ] }, "reaction_10623481": { "compartment": "compartment_70101", "id": "reaction_10623481", "reactome": "R-DDI-8950782", "name": "p-STAT1 binds p-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596995", "species_10594320" ], "products": [ "species_10597001" ], "modifiers": [], "additional_components": [ "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167" ] }, "reaction_10623477": { "compartment": "compartment_70101", "id": "reaction_10623477", "reactome": "R-DDI-8950778", "name": "p-Y693-STAT4 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623421" ], "products": [ "species_10623423" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "Q70GP4", "DDB_G0268638", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "Q70GP4", "DDB_G0268638" ] }, "reaction_10623437": { "compartment": "compartment_70101", "id": "reaction_10623437", "reactome": "R-DDI-8950181", "name": "Y693-STAT4 dimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623423" ], "products": [ "species_10623435" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "O00910", "DDB_G0281381", "Q86I20", "DDB_G0275167", "Q70GP4", "DDB_G0268638" ] }, "reaction_10624465": { "compartment": "compartment_70101", "id": "reaction_10624465", "reactome": "R-DDI-8987007", "name": "p-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623451" ], "products": [ "species_10624463" ], "modifiers": [], "additional_components": [ "Q54BD4", "DDB_G0293532", "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q54BD4", "DDB_G0293532", "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167" ] }, "reaction_10612568": { "compartment": "compartment_70101", "id": "reaction_10612568", "reactome": "R-DDI-6784763", "name": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596999" ], "products": [ "species_10597019" ], "modifiers": [], "additional_components": [ "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381" ] }, "reaction_10624491": { "compartment": "compartment_70101", "id": "reaction_10624491", "reactome": "R-DDI-8987052", "name": "p-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624477" ], "products": [ "species_10624489" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381" ] }, "reaction_10612570": { "compartment": "compartment_70101", "id": "reaction_10612570", "reactome": "R-DDI-6784765", "name": "p-Y705-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596995" ], "products": [ "species_10596999" ], "modifiers": [], "additional_components": [ "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638" ] }, "reaction_10624495": { "compartment": "compartment_70101", "id": "reaction_10624495", "reactome": "R-DDI-8987214", "name": "p-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624475" ], "products": [ "species_10624477" ], "modifiers": [], "additional_components": [ "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167" ] }, "reaction_10624509": { "compartment": "compartment_70101", "id": "reaction_10624509", "reactome": "R-DDI-8987218", "name": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624463" ], "products": [ "species_10624507" ], "modifiers": [], "additional_components": [ "Q54BD4", "DDB_G0293532", "O00910", "DDB_G0281381", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "Q54BD4", "DDB_G0293532", "O00910", "DDB_G0281381", "Q86I20", "DDB_G0275167", "Q70GP4", "DDB_G0268638" ] }, "reaction_10603411": { "compartment": "compartment_876", "id": "reaction_10603411", "reactome": "R-DDI-3928619", "name": "PAK1 binds RAC1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590366", "species_10588143" ], "products": [ "species_10603409" ], "modifiers": [], "additional_components": [ "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "P34144", "DDB_G0277869", "species_29438", "P34144", "DDB_G0277869", "species_29438", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459" ] }, "reaction_10603426": { "compartment": "compartment_70101", "id": "reaction_10603426", "reactome": "R-DDI-3928620", "name": "PAK1 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10603409" ], "products": [ "species_10603423", "species_29370" ], "modifiers": [ [ "species_10603409", "catalyst" ] ], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459", "P34144", "DDB_G0277869", "species_29438", "P34144", "DDB_G0277869", "species_29438", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459" ] }, "reaction_10611057": { "compartment": "compartment_161320", "id": "reaction_10611057", "reactome": "R-DDI-5690517", "name": "PPT1 hydrolyses palmitoylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_5690533" ], "products": [ "species_6785219", "species_5690516" ], "modifiers": [ [ "species_10611054", "catalyst" ] ], "additional_components": [ "species_3632881", "species_6785219", "DDB_G0285533" ] }, "reaction_10624098": { "compartment": "compartment_5460", "id": "reaction_10624098", "reactome": "R-DDI-8957389", "name": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8957387" ], "products": [ "species_8957386", "species_113521" ], "modifiers": [ [ "species_10624095", "catalyst" ] ], "additional_components": [ "DDB_G0281965" ] }, "reaction_10593969": { "compartment": "compartment_70101", "id": "reaction_10593969", "reactome": "R-DDI-548800", "name": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_548819", "species_29508" ], "products": [ "species_113528", "species_548816", "species_76194" ], "modifiers": [ [ "species_10593966", "catalyst" ] ], "additional_components": [ "Q55BY4", "DDB_G0271066", "C7FZW5", "DDB_G0271066" ] }, "reaction_10593985": { "compartment": "compartment_70101", "id": "reaction_10593985", "reactome": "R-DDI-548818", "name": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_548812" ], "products": [ "species_548836", "species_29366" ], "modifiers": [ [ "species_10593982", "catalyst" ] ], "additional_components": [ "Q869Y3", "DDB_G0275049" ] }, "reaction_10593995": { "compartment": "compartment_70101", "id": "reaction_10593995", "reactome": "R-DDI-548831", "name": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_548809" ], "products": [ "species_428139", "species_29366" ], "modifiers": [ [ "species_10593990", "catalyst" ] ], "additional_components": [ "DDB_G0270270" ] }, "reaction_10593978": { "compartment": "compartment_70101", "id": "reaction_10593978", "reactome": "R-DDI-548814", "name": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29508", "species_200993" ], "products": [ "species_113528", "species_548812", "species_76194" ], "modifiers": [ [ "species_10593975", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10587452": { "compartment": "compartment_70101", "id": "reaction_10587452", "reactome": "R-DDI-201035", "name": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_3632881", "species_76194" ], "products": [ "species_111294", "species_29356", "species_200993", "species_76577" ], "modifiers": [ [ "species_10587449", "catalyst" ] ], "additional_components": [ "Q54JK0", "DDB_G0288001", "Q55DR6", "DDB_G0269242", "Q1ZXQ4", "DDB_G0269474" ] }, "reaction_10593980": { "compartment": "compartment_70101", "id": "reaction_10593980", "reactome": "R-DDI-548815", "name": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29508", "species_548794" ], "products": [ "species_113528", "species_548829", "species_76194" ], "modifiers": [ [ "species_10593975", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10607615": { "compartment": "compartment_12045", "id": "reaction_10607615", "reactome": "R-DDI-5676637", "name": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676631" ], "products": [ "species_29356", "species_5676634" ], "modifiers": [ [ "species_10607612", "catalyst" ] ], "additional_components": [ "Q54Y54", "DDB_G0278683", "Q54YR9", "DDB_G0278113" ] }, "reaction_10611854": { "compartment": "compartment_70101", "id": "reaction_10611854", "reactome": "R-DDI-5695957", "name": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_5695985", "species_76194" ], "products": [ "species_111294", "species_5695971", "species_76577" ], "modifiers": [ [ "species_10611851", "catalyst" ] ], "additional_components": [ "Q55CD5", "DDB_G0270106" ] }, "reaction_10611870": { "compartment": "compartment_5460", "id": "reaction_10611870", "reactome": "R-DDI-5696007", "name": "ACSF3 ligates CoA-SH to VLCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_5696008", "species_113593" ], "products": [ "species_159448", "species_159450", "species_5696003" ], "modifiers": [ [ "species_10611867", "catalyst" ] ], "additional_components": [ "DDB_G0289539" ] }, "reaction_10587362": { "compartment": "compartment_70101", "id": "reaction_10587362", "reactome": "R-DDI-200555", "name": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_113592", "species_76183" ], "products": [ "species_29372", "species_29370", "species_29508" ], "modifiers": [ [ "species_10581617", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "DDB_G0288387" ] }, "reaction_10581606": { "compartment": "compartment_70101", "id": "reaction_10581606", "reactome": "R-DDI-75848", "name": "ACLY tetramer transforms CIT to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76190", "species_113592", "species_76194" ], "products": [ "species_29372", "species_29370", "species_76183", "species_76213" ], "modifiers": [ [ "species_10581603", "catalyst" ] ], "additional_components": [ "Q54YA2", "DDB_G0278341" ] }, "reaction_10581675": { "compartment": "compartment_70101", "id": "reaction_10581675", "reactome": "R-DDI-75872", "name": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_76183", "species_29364", "species_29508" ], "products": [ "species_29356", "species_113528", "species_29366", "species_3632881", "species_76194" ], "modifiers": [ [ "species_10581672", "catalyst" ] ], "additional_components": [ "Q869X2", "DDB_G0275077", "Q55E72", "DDB_G0269364", "Q869W9", "DDB_G0275069" ] }, "reaction_10584076": { "compartment": "compartment_70101", "id": "reaction_10584076", "reactome": "R-DDI-163756", "name": "Formation of fatty acid synthase (FAS) dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581670" ], "products": [ "species_10581672" ], "modifiers": [], "additional_components": [ "Q869X2", "DDB_G0275077", "Q55E72", "DDB_G0269364", "Q869W9", "DDB_G0275069", "Q869X2", "DDB_G0275077", "Q55E72", "DDB_G0269364", "Q869W9", "DDB_G0275069" ] }, "reaction_10625008": { "compartment": "compartment_70101", "id": "reaction_10625008", "reactome": "R-DDI-9014641", "name": "HRSP12 deaminates 2AA to 2OBUTA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9014643" ], "products": [ "species_29382", "species_936714" ], "modifiers": [ [ "species_10625005", "catalyst" ] ], "additional_components": [ "DDB_G0277761" ] }, "reaction_10625000": { "compartment": "compartment_70101", "id": "reaction_10625000", "reactome": "R-DDI-9014627", "name": "SDS dimers:PXLP dehydrate L-Thr to 2AA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351990" ], "products": [ "species_29356", "species_9014643" ], "modifiers": [ [ "species_10624997", "catalyst" ] ], "additional_components": [ "Q86B06", "DDB_G0272787" ] }, "reaction_10585185": { "compartment": "compartment_876", "id": "reaction_10585185", "reactome": "R-DDI-170986", "name": "Ral-GDS binds to Ras-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585181", "species_10585144" ], "products": [ "species_10585183" ], "modifiers": [], "additional_components": [ "Q8IS18", "DDB_G0269252", "Q54WL2", "DDB_G0279569", "Q552M5", "DDB_G0276019", "Q8IS19", "DDB_G0289667", "Q8SSQ3", "DDB_G0274607", "Q54L90", "DDB_G0286773", "Q86G47", "DDB_G0289665", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q8IS18", "DDB_G0269252", "Q54WL2", "DDB_G0279569", "Q552M5", "DDB_G0276019", "Q8IS19", "DDB_G0289667", "Q8SSQ3", "DDB_G0274607", "Q54L90", "DDB_G0286773", "Q86G47", "DDB_G0289665" ] }, "reaction_10626117": { "compartment": "compartment_7660", "id": "reaction_10626117", "reactome": "R-DDI-9612509", "name": "SGK phosphorylates SRF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10626105" ], "products": [ "species_113582", "species_10626108" ], "modifiers": [ [ "species_10626114", "catalyst" ] ], "additional_components": [ "DDB_G0281387", "DDB_G0281387", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620" ] }, "reaction_10587062": { "compartment": "compartment_7660", "id": "reaction_10587062", "reactome": "R-DDI-198714", "name": "ERK5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587058" ], "products": [ "species_10587060" ], "modifiers": [], "additional_components": [ "DDB_G0286353", "DDB_G0286353" ] }, "reaction_10591923": { "compartment": "compartment_70101", "id": "reaction_10591923", "reactome": "R-DDI-430021", "name": "PAN2-PAN3 complex partially deadenylates mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10591908" ], "products": [ "species_10591904", "species_76577" ], "modifiers": [ [ "species_10591920", "catalyst" ] ], "additional_components": [ "Q75K16", "DDB_G0275459", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "Q54BM2", "DDB_G0293558", "Q55D61", "DDB_G0269192", "P90529", "DDB_G0269146", "Q75K16", "DDB_G0275459", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "Q54BM2", "DDB_G0293558", "Q55D61", "DDB_G0269192", "P90529", "DDB_G0269146", "Q55DD5", "DDB_G0269694", "P0CD65", "DDB_G0279129" ] }, "reaction_10623223": { "compartment": "compartment_70101", "id": "reaction_10623223", "reactome": "R-DDI-8941312", "name": "ZCCHC6, ZCCHC11 are mRNA uridyltransferases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6782337", "species_10591904" ], "products": [ "species_10623193" ], "modifiers": [ [ "species_10623220", "catalyst" ] ], "additional_components": [ "Q75K16", "DDB_G0275459", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "Q54BM2", "DDB_G0293558", "Q55D61", "DDB_G0269192", "P90529", "DDB_G0269146", "species_6782337", "Q75K16", "DDB_G0275459", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "Q54BM2", "DDB_G0293558", "Q55D61", "DDB_G0269192", "P90529", "DDB_G0269146", "Q8T2J7", "DDB_G0281431", "Q54Y43", "DDB_G0281431", "Q54TZ1", "DDB_G0281431" ] }, "reaction_10625515": { "compartment": "compartment_70101", "id": "reaction_10625515", "reactome": "R-DDI-9026005", "name": "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9026293", "species_29368" ], "products": [ "species_9026311" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625519": { "compartment": "compartment_70101", "id": "reaction_10625519", "reactome": "R-DDI-9026007", "name": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9025012", "species_29366" ], "products": [ "species_9026307", "species_29364" ], "modifiers": [ [ "species_10600421", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10625517": { "compartment": "compartment_70101", "id": "reaction_10625517", "reactome": "R-DDI-9026006", "name": "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9608444", "species_29368" ], "products": [ "species_9026293" ], "modifiers": [ [ "species_10600421", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10587587": { "compartment": "compartment_70101", "id": "reaction_10587587", "reactome": "R-DDI-202127", "name": "eNOS synthesizes NO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468", "species_29368", "species_29364" ], "products": [ "species_202124", "species_29366", "species_29968" ], "modifiers": [ [ "species_10587584", "catalyst" ], [ "species_5693375", "inhibitor" ] ], "additional_components": [ "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "P54651", "DDB_G0267400", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_29870" ] }, "reaction_10587763": { "compartment": "compartment_876", "id": "reaction_10587763", "reactome": "R-DDI-203613", "name": "depalmitoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587546" ], "products": [ "species_76168", "species_10587591" ], "modifiers": [ [ "species_10587760", "catalyst" ] ], "additional_components": [ "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_917877", "species_29426", "Q55CT1", "DDB_G0269912", "species_76629", "species_113596", "species_29870", "Q54T49", "DDB_G0282005" ] }, "reaction_10587749": { "compartment": "compartment_20699", "id": "reaction_10587749", "reactome": "R-DDI-203567", "name": "palmitoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587589", "species_200993" ], "products": [ "species_10587719" ], "modifiers": [ [ "species_10587746", "catalyst" ] ], "additional_components": [ "DDB_G0269912", "DDB_G0269912", "Q54VH7", "DDB_G0293930", "Q86A83", "DDB_G0293930", "Q552M6", "DDB_G0293930", "Q555N7", "DDB_G0293930", "Q54B34", "DDB_G0293930" ] }, "reaction_10598261": { "compartment": "compartment_70101", "id": "reaction_10598261", "reactome": "R-DDI-1497784", "name": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_10587580" ], "products": [ "species_10587584" ], "modifiers": [], "additional_components": [ "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "P54651", "DDB_G0267400", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_29870", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "P54651", "DDB_G0267400", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_29870" ] }, "reaction_10598276": { "compartment": "compartment_70101", "id": "reaction_10598276", "reactome": "R-DDI-1497869", "name": "Salvage - Sepiapterin is reduced to BH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_1497811", "species_29364" ], "products": [ "species_1497857", "species_29366" ], "modifiers": [ [ "species_10597898", "catalyst" ] ], "additional_components": [ "Q54GP3", "DDB_G0290009" ] }, "reaction_10587753": { "compartment": "compartment_70101", "id": "reaction_10587753", "reactome": "R-DDI-203611", "name": "N-myristoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_184174", "species_10587751" ], "products": [ "species_10587589" ], "modifiers": [], "additional_components": [ "DDB_G0269912", "DDB_G0269912" ] }, "reaction_10598265": { "compartment": "compartment_70101", "id": "reaction_10598265", "reactome": "R-DDI-1497796", "name": "BH2 binding can lead to eNOS uncoupling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1497857", "species_10587584" ], "products": [ "species_29870", "species_10598263" ], "modifiers": [], "additional_components": [ "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "P54651", "DDB_G0267400", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_29870", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "P54651", "DDB_G0267400", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_1497857", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_29870" ] }, "reaction_10587773": { "compartment": "compartment_20699", "id": "reaction_10587773", "reactome": "R-DDI-203700", "name": "eNOS translocation from Golgi to Caveolae", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587719" ], "products": [ "species_10587546" ], "modifiers": [], "additional_components": [ "DDB_G0269912", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596" ] }, "reaction_10587597": { "compartment": "compartment_20699", "id": "reaction_10587597", "reactome": "R-DDI-202132", "name": "depalmitoylated eNOS translocates from plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587591" ], "products": [ "species_10587595" ], "modifiers": [], "additional_components": [ "species_917877", "species_29426", "Q55CT1", "DDB_G0269912", "species_76629", "species_113596", "species_29870", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_29870" ] }, "reaction_10598268": { "compartment": "compartment_70101", "id": "reaction_10598268", "reactome": "R-DDI-1497810", "name": "Uncoupled eNOS favours the formation of superoxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29364" ], "products": [ "species_1222424", "species_29366" ], "modifiers": [ [ "species_10598263", "catalyst" ] ], "additional_components": [ "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "P54651", "DDB_G0267400", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_1497857", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_29870" ] }, "reaction_10587599": { "compartment": "compartment_70101", "id": "reaction_10587599", "reactome": "R-DDI-202137", "name": "AKT1 binds eNOS complex via HSP90", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587563", "species_10586949" ], "products": [ "species_10587571" ], "modifiers": [], "additional_components": [ "Q7Z2B8", "DDB_G0277917", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "species_74112", "P54651", "DDB_G0267400", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "Q7Z2B8", "DDB_G0277917", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "species_74112", "P54651", "DDB_G0267400", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596" ] }, "reaction_10587582": { "compartment": "compartment_70101", "id": "reaction_10587582", "reactome": "R-DDI-202111", "name": "AKT1 phosphorylates eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10587571" ], "products": [ "species_10587580", "species_29370" ], "modifiers": [], "additional_components": [ "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "Q7Z2B8", "DDB_G0277917", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "species_74112", "P54651", "DDB_G0267400", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "P54651", "DDB_G0267400", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_29870" ] }, "reaction_10592001": { "compartment": "compartment_70101", "id": "reaction_10592001", "reactome": "R-DDI-430028", "name": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429974" ], "products": [ "species_109402", "species_113578", "species_109395", "species_429926", "species_76577" ], "modifiers": [ [ "species_10591998", "catalyst" ] ], "additional_components": [ "Q54HV0", "DDB_G0289175", "Q54S59", "DDB_G0282793", "Q86K90", "DDB_G0277211", "Q55BJ2", "DDB_G0271100", "Q54VM4", "DDB_G0280251", "Q54CU6", "DDB_G0292692", "Q55BB0", "DDB_G0271396", "Q54EU6", "DDB_G0291328", "Q54Q83", "DDB_G0284053", "Q54EV5", "DDB_G0291310", "Q54N99", "DDB_G0285377", "Q54BH9", "DDB_G0293614", "Q7KWX9", "DDB_G0276783", "Q54QJ0", "DDB_G0283769" ] }, "reaction_10597571": { "compartment": "compartment_7660", "id": "reaction_10597571", "reactome": "R-DDI-1363311", "name": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597257", "species_10597559" ], "products": [ "species_10597569" ], "modifiers": [], "additional_components": [ "Q54FX2", "DDB_G0290551", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "P34112", "DDB_G0272813", "P34112", "DDB_G0272813", "Q54FX2", "DDB_G0290551", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129" ] }, "reaction_10597575": { "compartment": "compartment_7660", "id": "reaction_10597575", "reactome": "R-DDI-1363314", "name": "p107 (RBL1) binds CyclinE/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597559", "species_10597255" ], "products": [ "species_10597573" ], "modifiers": [], "additional_components": [ "P34112", "DDB_G0272813", "DDB_G0290551", "Q54FX2", "DDB_G0290551", "P34112", "DDB_G0272813" ] }, "reaction_10597563": { "compartment": "compartment_7660", "id": "reaction_10597563", "reactome": "R-DDI-1363303", "name": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597246", "species_10597559" ], "products": [ "species_10597561" ], "modifiers": [], "additional_components": [ "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551", "Q7KWP1", "DDB_G0276799", "P34112", "DDB_G0272813", "P34112", "DDB_G0272813", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551", "Q7KWP1", "DDB_G0276799" ] }, "reaction_10597274": { "compartment": "compartment_7660", "id": "reaction_10597274", "reactome": "R-DDI-1227670", "name": "Recruitment of HDAC1 by p130 (RBL2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597246", "species_10597270" ], "products": [ "species_10597272" ], "modifiers": [], "additional_components": [ "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551", "Q7KWP1", "DDB_G0276799", "DDB_G0268024", "Q55FN5", "DDB_G0268024", "Q54Q23", "DDB_G0284129", "Q54FX2", "DDB_G0290551", "Q7KWP1", "DDB_G0276799" ] }, "reaction_10597567": { "compartment": "compartment_7660", "id": "reaction_10597567", "reactome": "R-DDI-1363306", "name": "p130 (RBL2) binds Cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597229", "species_10597559" ], "products": [ "species_10597565" ], "modifiers": [], "additional_components": [ "DDB_G0290551", "P34112", "DDB_G0272813", "P34112", "DDB_G0272813", "Q54FX2", "DDB_G0290551" ] }, "reaction_10597278": { "compartment": "compartment_7660", "id": "reaction_10597278", "reactome": "R-DDI-1227671", "name": "Recruitment of HDAC1 by p107 (RBL1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597257", "species_10597270" ], "products": [ "species_10597276" ], "modifiers": [], "additional_components": [ "Q54FX2", "DDB_G0290551", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "DDB_G0268024", "Q55FN5", "DDB_G0268024", "Q54FX2", "DDB_G0290551", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129" ] }, "reaction_10586837": { "compartment": "compartment_70101", "id": "reaction_10586837", "reactome": "R-DDI-196929", "name": "FLAD1 phosphorylates FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_73524" ], "products": [ "species_111294", "species_29386" ], "modifiers": [ [ "species_10586834", "catalyst" ] ], "additional_components": [ "DDB_G0282955" ] }, "reaction_10586847": { "compartment": "compartment_70101", "id": "reaction_10586847", "reactome": "R-DDI-196955", "name": "2xENPP1 hydrolyzes FAD to FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29386" ], "products": [ "species_73524", "species_76577" ], "modifiers": [ [ "species_10586844", "catalyst" ] ], "additional_components": [ "Q54MJ8", "DDB_G0285897" ] }, "reaction_10604772": { "compartment": "compartment_13231", "id": "reaction_10604772", "reactome": "R-DDI-5221130", "name": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_5221122" ], "products": [ "species_113550", "species_5221124" ], "modifiers": [ [ "species_10603651", "catalyst" ] ], "additional_components": [ "Q75JA1", "DDB_G0271730" ] }, "reaction_10602755": { "compartment": "compartment_70101", "id": "reaction_10602755", "reactome": "R-DDI-3371422", "name": "ATP hydrolysis by HSP70", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602750" ], "products": [ "species_29372", "species_10602752" ], "modifiers": [ [ "species_10602750", "catalyst" ], [ "species_10602748", "catalyst" ] ], "additional_components": [ "species_113592", "P36415", "DDB_G0269144", "Q54VQ1", "DDB_G0280037", "Q54ED3", "DDB_G0291568", "species_29370", "P36415", "DDB_G0269144", "Q54VQ1", "DDB_G0280037", "Q54ED3", "DDB_G0291568", "species_113592", "P36415", "DDB_G0269144", "Q54VQ1", "DDB_G0280037", "Q54ED3", "DDB_G0291568", "Q54VQ1", "DDB_G0280037", "Q54ED3", "DDB_G0291568" ] }, "reaction_10605698": { "compartment": "compartment_70101", "id": "reaction_10605698", "reactome": "R-DDI-5618098", "name": "p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589012", "species_10605696" ], "products": [ "species_10602796", "species_10602861", "species_10605561" ], "modifiers": [], "additional_components": [ "DDB_G0268042", "Q54QI6", "DDB_G0283815", "species_29370", "P36415", "DDB_G0269144", "P54651", "DDB_G0267400", "species_113592", "Q54DA8", "DDB_G0292404", "DDB_G0292404", "species_113592", "P36415", "DDB_G0269144", "Q54QI6", "DDB_G0283815", "Q55FM3", "DDB_G0268042", "P54651", "DDB_G0267400", "species_113592" ] }, "reaction_10605704": { "compartment": "compartment_70101", "id": "reaction_10605704", "reactome": "R-DDI-5618099", "name": "SH binds SHR within the HSP90 chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5618094", "species_10605702" ], "products": [ "species_10605571" ], "modifiers": [], "additional_components": [ "species_193057", "species_469662", "CHEBI:16973", "CHEBI:17650", "CHEBI:27584", "species_193055", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "species_113592", "Q54QI6", "DDB_G0283815", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "species_113592", "Q54QI6", "DDB_G0283815" ] }, "reaction_10605706": { "compartment": "compartment_70101", "id": "reaction_10605706", "reactome": "R-DDI-5618105", "name": "FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605688", "species_10605557" ], "products": [ "species_10605696" ], "modifiers": [], "additional_components": [ "species_29370", "P36415", "DDB_G0269144", "P54651", "DDB_G0267400", "species_113592", "Q54DA8", "DDB_G0292404", "DDB_G0283815", "Q54QI6", "DDB_G0283815", "species_29370", "P36415", "DDB_G0269144", "P54651", "DDB_G0267400", "species_113592", "Q54DA8", "DDB_G0292404" ] }, "reaction_10627342": { "compartment": "compartment_70101", "id": "reaction_10627342", "reactome": "R-DDI-9678925", "name": "NR3C1 binds NR3C1 agonists", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9678859", "species_10605575" ], "products": [ "species_10627340" ], "modifiers": [], "additional_components": [ "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "species_113592", "Q54QI6", "DDB_G0283815", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "species_113592", "Q54QI6", "DDB_G0283815" ] }, "reaction_10605708": { "compartment": "compartment_70101", "id": "reaction_10605708", "reactome": "R-DDI-5618107", "name": "ATP binding to HSP90 triggers conformation change", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10602808" ], "products": [ "species_10605688" ], "modifiers": [], "additional_components": [ "P54651", "DDB_G0267400", "species_29370", "P36415", "DDB_G0269144", "Q54DA8", "DDB_G0292404", "species_29370", "P36415", "DDB_G0269144", "P54651", "DDB_G0267400", "species_113592", "Q54DA8", "DDB_G0292404" ] }, "reaction_10602863": { "compartment": "compartment_70101", "id": "reaction_10602863", "reactome": "R-DDI-3371590", "name": "HSP70 binds to HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602861", "species_10602859" ], "products": [ "species_10602750" ], "modifiers": [], "additional_components": [ "species_113592", "P36415", "DDB_G0269144", "Q54VQ1", "DDB_G0280037", "Q54ED3", "DDB_G0291568", "species_113592", "P36415", "DDB_G0269144", "Q54VQ1", "DDB_G0280037", "Q54ED3", "DDB_G0291568" ] }, "reaction_10605710": { "compartment": "compartment_70101", "id": "reaction_10605710", "reactome": "R-DDI-5618110", "name": "p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605690", "species_10589012" ], "products": [ "species_10602796", "species_10605565", "species_10602861" ], "modifiers": [], "additional_components": [ "species_29370", "P36415", "DDB_G0269144", "P54651", "DDB_G0267400", "species_113592", "Q54DA8", "DDB_G0292404", "Q54QI6", "DDB_G0283815", "DDB_G0268042", "DDB_G0292404", "Q55FM3", "DDB_G0268042", "P54651", "DDB_G0267400", "species_113592", "Q54QI6", "DDB_G0283815", "species_113592", "P36415", "DDB_G0269144" ] }, "reaction_10627379": { "compartment": "compartment_70101", "id": "reaction_10627379", "reactome": "R-DDI-9690534", "name": "SH binds NR3C1 (in HSP90:ATP:FKBP4:PTGES3:NR3C1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5618094", "species_10605575" ], "products": [ "species_10605577" ], "modifiers": [ [ "species_10627340", "catalyst" ] ], "additional_components": [ "species_193057", "species_469662", "CHEBI:16973", "CHEBI:17650", "CHEBI:27584", "species_193055", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "species_113592", "Q54QI6", "DDB_G0283815", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "species_113592", "Q54QI6", "DDB_G0283815", "species_193057", "species_469662", "CHEBI:16973", "CHEBI:17650", "CHEBI:27584", "species_193055", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "species_113592", "Q54QI6", "DDB_G0283815" ] }, "reaction_10605685": { "compartment": "compartment_70101", "id": "reaction_10605685", "reactome": "R-DDI-5618080", "name": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605577", "species_10605571" ], "products": [ "species_10605581", "species_10605587" ], "modifiers": [ [ "species_10605683", "catalyst" ] ], "additional_components": [ "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "species_113592", "Q54QI6", "DDB_G0283815", "species_193057", "species_469662", "CHEBI:16973", "CHEBI:17650", "CHEBI:27584", "species_193055", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "species_113592", "Q54QI6", "DDB_G0283815", "Q54QI6", "DDB_G0283815", "P54651", "DDB_G0267400", "species_113592", "Q55FM3", "DDB_G0268042", "Q54QI6", "DDB_G0283815", "P54651", "DDB_G0267400", "species_113592", "Q55FM3", "DDB_G0268042", "species_469662", "CHEBI:17650", "species_193055", "CHEBI:27584", "CHEBI:16973", "species_193057", "P54703", "DDB_G0280849", "Q86A88", "DDB_G0274815", "Q54CI8", "DDB_G0292904", "P34036", "DDB_G0276355", "Q54VD6", "DDB_G0280435", "Q54ZI7", "DDB_G0277561", "Q54N50", "DDB_G0285503", "P13021", "DDB_G0267374", "P13022", "DDB_G0272104", "Q54JY2", "DDB_G0287739", "Q54FM4", "DDB_G0290757", "Q54VS0", "DDB_G0280175", "Q54XU5", "DDB_G0278579", "Q54I79", "DDB_G0288937", "species_29438", "species_29420" ] }, "reaction_10627419": { "compartment": "compartment_70101", "id": "reaction_10627419", "reactome": "R-DDI-9705925", "name": "Androgens binds AR (in the HSP90 chaperone complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8979218", "species_10627413" ], "products": [ "species_10627417" ], "modifiers": [], "additional_components": [ "species_193057", "species_193079", "species_469662", "CHEBI:29117", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "species_113592", "Q54QI6", "DDB_G0283815", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "species_193057", "species_193079", "species_469662", "CHEBI:29117", "species_113592", "Q54QI6", "DDB_G0283815" ] }, "reaction_10602810": { "compartment": "compartment_70101", "id": "reaction_10602810", "reactome": "R-DDI-3371503", "name": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602796", "species_10602802", "species_10602752" ], "products": [ "species_10602748", "species_10602808" ], "modifiers": [], "additional_components": [ "DDB_G0292404", "P54651", "DDB_G0267400", "species_29370", "P36415", "DDB_G0269144", "Q54VQ1", "DDB_G0280037", "Q54ED3", "DDB_G0291568", "Q54VQ1", "DDB_G0280037", "Q54ED3", "DDB_G0291568", "P54651", "DDB_G0267400", "species_29370", "P36415", "DDB_G0269144", "Q54DA8", "DDB_G0292404" ] }, "reaction_10605692": { "compartment": "compartment_70101", "id": "reaction_10605692", "reactome": "R-DDI-5618085", "name": "FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605563", "species_10605688" ], "products": [ "species_10605690" ], "modifiers": [], "additional_components": [ "DDB_G0283815", "species_29370", "P36415", "DDB_G0269144", "P54651", "DDB_G0267400", "species_113592", "Q54DA8", "DDB_G0292404", "species_29370", "P36415", "DDB_G0269144", "P54651", "DDB_G0267400", "species_113592", "Q54DA8", "DDB_G0292404", "Q54QI6", "DDB_G0283815" ] }, "reaction_10605567": { "compartment": "compartment_70101", "id": "reaction_10605567", "reactome": "R-DDI-5618073", "name": "FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605563", "species_10605561" ], "products": [ "species_10605565", "species_10605557" ], "modifiers": [ [ "species_5618094", "catalyst" ] ], "additional_components": [ "DDB_G0283815", "Q54QI6", "DDB_G0283815", "Q55FM3", "DDB_G0268042", "P54651", "DDB_G0267400", "species_113592", "Q55FM3", "DDB_G0268042", "P54651", "DDB_G0267400", "species_113592", "Q54QI6", "DDB_G0283815", "DDB_G0283815", "species_193057", "species_469662", "CHEBI:16973", "CHEBI:17650", "CHEBI:27584", "species_193055" ] }, "reaction_10584784": { "compartment": "compartment_5460", "id": "reaction_10584784", "reactome": "R-DDI-169270", "name": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73663", "species_10584773" ], "products": [ "species_76633", "species_10584771" ], "modifiers": [ [ "species_10584781", "catalyst" ] ], "additional_components": [ "Q54YZ4", "DDB_G0277991", "species_31649", "species_76577", "Q54FD7", "DDB_G0290927", "Q54YZ4", "DDB_G0277991", "species_76577", "Q54FD7", "DDB_G0290927", "species_113596", "DDB_G0278849" ] }, "reaction_10612771": { "compartment": "compartment_5460", "id": "reaction_10612771", "reactome": "R-DDI-6788523", "name": "NUBPL transfers 4Fe-4S to Complex I subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612759", "species_10610755" ], "products": [ "species_10610753", "species_10612769" ], "modifiers": [], "additional_components": [ "Q54NI6", "DDB_G0285239", "Q86K57", "DDB_G0277231", "Q34312", "DDB_G0294052", "Q23883", "DDB_G0294030", "Q54F15", "DDB_G0291193", "DDB_G0291193", "Q34312", "DDB_G0294052", "Q23883", "DDB_G0294030", "Q54NI6", "DDB_G0285239", "Q86K57", "DDB_G0277231" ] }, "reaction_10612787": { "compartment": "compartment_5460", "id": "reaction_10612787", "reactome": "R-DDI-6788556", "name": "NUBPL transfers 4Fe-4S to NDUFV1, V2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612781", "species_10612776", "species_76629", "species_10610755" ], "products": [ "species_10612783", "species_10610753", "species_10612785" ], "modifiers": [], "additional_components": [ "DDB_G0291173", "DDB_G0288875", "Q54F15", "DDB_G0291193", "species_76629", "Q54I90", "DDB_G0288875", "DDB_G0291193", "Q54F10", "DDB_G0291173" ] }, "reaction_10610757": { "compartment": "compartment_5460", "id": "reaction_10610757", "reactome": "R-DDI-5690023", "name": "NUBPL binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_169274", "species_10610753" ], "products": [ "species_10610755" ], "modifiers": [], "additional_components": [ "DDB_G0291193", "Q54F15", "DDB_G0291193" ] }, "reaction_10616447": { "compartment": "compartment_5460", "id": "reaction_10616447", "reactome": "R-DDI-6800868", "name": "NDUF subunits bind to form the IP subcomplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612767", "species_10615711", "species_10612765", "species_10615723", "species_10615718" ], "products": [ "species_10615725" ], "modifiers": [], "additional_components": [ "Q86K57", "DDB_G0277231", "Q23883", "DDB_G0294030", "Q54S83", "DDB_G0282615", "Q54NI6", "DDB_G0285239", "DDB_G0294032", "Q559Z0", "DDB_G0272266", "species_113596", "Q559Z0", "DDB_G0272266", "species_113596", "P22237", "DDB_G0294032", "Q54NI6", "DDB_G0285239", "Q23883", "DDB_G0294030", "Q54S83", "DDB_G0282615", "Q86K57", "DDB_G0277231" ] }, "reaction_10584776": { "compartment": "compartment_5460", "id": "reaction_10584776", "reactome": "R-DDI-169260", "name": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584771", "species_31649" ], "products": [ "species_113596", "species_10584773" ], "modifiers": [ [ "species_10584771", "catalyst" ] ], "additional_components": [ "Q54YZ4", "DDB_G0277991", "species_76577", "Q54FD7", "DDB_G0290927", "species_113596", "Q54YZ4", "DDB_G0277991", "species_31649", "species_76577", "Q54FD7", "DDB_G0290927", "Q54YZ4", "DDB_G0277991", "species_76577", "Q54FD7", "DDB_G0290927", "species_113596" ] }, "reaction_10584136": { "compartment": "compartment_70616", "id": "reaction_10584136", "reactome": "R-DDI-164651", "name": "Electron transfer from ubiquinol to cytochrome c of complex III", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73663", "species_113529", "species_76633", "species_10584033" ], "products": [ "species_10584031", "species_73663", "species_76633", "species_163953" ], "modifiers": [ [ "species_10584133", "catalyst" ] ], "additional_components": [ "CHEBI:38574", "Q869N1", "DDB_G0275537", "CHEBI:38573", "Q869N1", "DDB_G0275537", "Q1ZXP3", "DDB_G0271774", "Q37311", "DDB_G0294078", "Q54NW9", "DDB_G0284947", "Q54V76", "DDB_G0280569", "Q4W6B5", "DDB_G0288777", "Q54M82", "DDB_G0286171", "Q54D07", "DDB_G0292594", "Q54QR8", "DDB_G0283669", "Q86A84", "DDB_G0274809" ] }, "reaction_10616628": { "compartment": "compartment_7660", "id": "reaction_10616628", "reactome": "R-DDI-6805640", "name": "AKT phosphorylates KAT6A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10616601" ], "products": [ "species_113582", "species_10616626" ], "modifiers": [ [ "species_10587267", "catalyst" ] ], "additional_components": [ "Q54QM3", "DDB_G0283859", "B0G130", "DDB_G0279699", "Q869X5", "DDB_G0279699", "Q54NG3", "DDB_G0285275", "Q54PN9", "DDB_G0284411", "Q54QM3", "DDB_G0283859", "B0G130", "DDB_G0279699", "Q869X5", "DDB_G0279699", "Q54NG3", "DDB_G0285275", "Q54PN9", "DDB_G0284411", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795" ] }, "reaction_10622674": { "compartment": "compartment_7660", "id": "reaction_10622674", "reactome": "R-DDI-8877692", "name": "PIN1 binds phosphorylated PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622667", "species_10594992" ], "products": [ "species_10622672" ], "modifiers": [], "additional_components": [ "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635", "Q86D86", "DDB_G0283615", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "DDB_G0268618", "Q55EZ0", "DDB_G0268618", "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635", "Q86D86", "DDB_G0283615", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190" ] }, "reaction_10617814": { "compartment": "compartment_7660", "id": "reaction_10617814", "reactome": "R-DDI-6811522", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6810408", "species_29358" ], "products": [ "species_113582", "species_6810412" ], "modifiers": [ [ "species_10617811", "catalyst" ] ], "additional_components": [ "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635", "Q86D86", "DDB_G0283615", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190" ] }, "reaction_10617479": { "compartment": "compartment_7660", "id": "reaction_10617479", "reactome": "R-DDI-6810376", "name": "ING2 binds PI5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6810408", "species_10603513" ], "products": [ "species_10617477" ], "modifiers": [], "additional_components": [ "DDB_G0284411", "Q54PN9", "DDB_G0284411", "species_6810408" ] }, "reaction_10622670": { "compartment": "compartment_7660", "id": "reaction_10622670", "reactome": "R-DDI-8877691", "name": "MAP2K6 phosphorylates PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10622656" ], "products": [ "species_113582", "species_10622667" ], "modifiers": [ [ "species_10593040", "catalyst" ] ], "additional_components": [ "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635", "Q86D86", "DDB_G0283615", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635", "Q86D86", "DDB_G0283615", "Q54M96", "DDB_G0292190", "Q54DL4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "DDB_G0289277" ] }, "reaction_10616616": { "compartment": "compartment_7660", "id": "reaction_10616616", "reactome": "R-DDI-6805638", "name": "KAT6A acetylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616607", "species_113560" ], "products": [ "species_2485002", "species_10616613" ], "modifiers": [ [ "species_10616607", "catalyst" ] ], "additional_components": [ "Q54QM3", "DDB_G0283859", "B0G130", "DDB_G0279699", "Q869X5", "DDB_G0279699", "Q54NG3", "DDB_G0285275", "Q54PN9", "DDB_G0284411", "Q54MF7", "DDB_G0285989", "Q54QM3", "DDB_G0283859", "B0G130", "DDB_G0279699", "Q869X5", "DDB_G0279699", "Q54NG3", "DDB_G0285275", "Q54PN9", "DDB_G0284411", "Q54MF7", "DDB_G0285989", "Q54QM3", "DDB_G0283859", "B0G130", "DDB_G0279699", "Q869X5", "DDB_G0279699", "Q54NG3", "DDB_G0285275", "Q54PN9", "DDB_G0284411", "Q54MF7", "DDB_G0285989" ] }, "reaction_10577937": { "compartment": "compartment_5460", "id": "reaction_10577937", "reactome": "R-DDI-70670", "name": "PRODH oxidises L-Pro to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113597", "species_379717" ], "products": [ "species_113529", "species_113590", "species_164934" ], "modifiers": [ [ "species_10577934", "catalyst" ] ], "additional_components": [ "DDB_G0275669" ] }, "reaction_10623999": { "compartment": "compartment_5460", "id": "reaction_10623999", "reactome": "R-DDI-8955817", "name": "PRODH2 oxidises HPRO to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113597", "species_6784215" ], "products": [ "species_113590", "species_164934", "species_113521" ], "modifiers": [ [ "species_10612516", "catalyst" ] ], "additional_components": [ "DDB_G0275669" ] }, "reaction_10597318": { "compartment": "compartment_70101", "id": "reaction_10597318", "reactome": "R-DDI-1247645", "name": "RHAG transports CO2 from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113528" ], "products": [ "species_1237009" ], "modifiers": [ [ "species_10592544", "catalyst" ] ], "additional_components": [ "Q8I0L6", "DDB_G0280059", "Q9NIV0", "DDB_G0283389" ] }, "reaction_10597320": { "compartment": "compartment_70101", "id": "reaction_10597320", "reactome": "R-DDI-1247649", "name": "AQP1 tetramer transports CO2 from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113528" ], "products": [ "species_1237009" ], "modifiers": [ [ "species_10592019", "catalyst" ] ], "additional_components": [ "Q9U8P7", "DDB_G0267378" ] }, "reaction_10608673": { "compartment": "compartment_7660", "id": "reaction_10608673", "reactome": "R-DDI-5687664", "name": "FEN1 cleaves displaced ssDNA flaps during MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10608663" ], "products": [ "species_10608670", "species_10577480", "species_68454" ], "modifiers": [ [ "species_10608663", "catalyst" ] ], "additional_components": [ "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54NU0", "DDB_G0284987", "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "DDB_G0284987", "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54NU0", "DDB_G0284987" ] }, "reaction_10608661": { "compartment": "compartment_7660", "id": "reaction_10608661", "reactome": "R-DDI-5687640", "name": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10608650" ], "products": [ "species_113541", "species_10608658" ], "modifiers": [ [ "species_10608650", "catalyst" ] ], "additional_components": [ "Q54S42", "DDB_G0282679", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54NU0", "DDB_G0284987", "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54S42", "DDB_G0282679", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q54NU0", "DDB_G0284987", "Q54S42", "DDB_G0282679", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54NU0", "DDB_G0284987" ] }, "reaction_10608677": { "compartment": "compartment_7660", "id": "reaction_10608677", "reactome": "R-DDI-5687673", "name": "MRN recruits LIG3:XRCC1 to MMEJ sites", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608670", "species_10580807" ], "products": [ "species_10608675" ], "modifiers": [], "additional_components": [ "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786" ] }, "reaction_10608666": { "compartment": "compartment_7660", "id": "reaction_10608666", "reactome": "R-DDI-5687653", "name": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427523", "species_10608658" ], "products": [ "species_427497", "species_10606279", "species_10608663", "species_10608644" ], "modifiers": [ [ "species_10608658", "catalyst" ] ], "additional_components": [ "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54S42", "DDB_G0282679", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q54NU0", "DDB_G0284987", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820", "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54NU0", "DDB_G0284987", "Q54S42", "DDB_G0282679", "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54S42", "DDB_G0282679", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q54NU0", "DDB_G0284987" ] }, "reaction_10608637": { "compartment": "compartment_7660", "id": "reaction_10608637", "reactome": "R-DDI-5687464", "name": "MRN and RBBP8 resect DNA DSBs in MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10608630" ], "products": [ "species_30555", "species_10608634" ], "modifiers": [ [ "species_10608630", "catalyst" ] ], "additional_components": [ "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786" ] }, "reaction_10608652": { "compartment": "compartment_7660", "id": "reaction_10608652", "reactome": "R-DDI-5687484", "name": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608634", "species_10577480", "species_10606233", "species_10608644" ], "products": [ "species_10608650" ], "modifiers": [], "additional_components": [ "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "DDB_G0284987", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q54S42", "DDB_G0282679", "Q54S42", "DDB_G0282679", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q54EK9", "DDB_G0291466", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54NU0", "DDB_G0284987" ] }, "reaction_10608369": { "compartment": "compartment_7660", "id": "reaction_10608369", "reactome": "R-DDI-5685230", "name": "CHEK1 phosphorylates RAD51", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10608364" ], "products": [ "species_113582", "species_10608367" ], "modifiers": [ [ "species_10577605", "catalyst" ] ], "additional_components": [ "DDB_G0273139", "DDB_G0273139", "DDB_G0279719" ] }, "reaction_10608453": { "compartment": "compartment_7660", "id": "reaction_10608453", "reactome": "R-DDI-5685341", "name": "BCDX2 complex stabilizes RAD51 filament", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608435", "species_10608449" ], "products": [ "species_10608451" ], "modifiers": [], "additional_components": [ "Q54BU8", "DDB_G0293414", "Q557E6", "DDB_G0273139", "Q86IV6", "DDB_G0274777", "Q54Q57", "DDB_G0284153", "Q54DM3", "DDB_G0292130", "Q54GC4", "DDB_G0290275", "Q8T2T7", "DDB_G0275257", "Q54ED2", "DDB_G0291570", "Q54EK9", "DDB_G0291466", "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54LI7", "DDB_G0286621", "Q1ZXF0", "DDB_G0285287", "Q54PJ7", "DDB_G0284507", "Q54G98", "DDB_G0290297", "Q1ZXF0", "DDB_G0285287", "Q54PJ7", "DDB_G0284507", "Q54G98", "DDB_G0290297", "Q54BU8", "DDB_G0293414", "Q557E6", "DDB_G0273139", "Q86IV6", "DDB_G0274777", "Q54Q57", "DDB_G0284153", "Q54DM3", "DDB_G0292130", "Q54GC4", "DDB_G0290275", "Q8T2T7", "DDB_G0275257", "Q54ED2", "DDB_G0291570", "Q54EK9", "DDB_G0291466", "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54LI7", "DDB_G0286621" ] }, "reaction_10608379": { "compartment": "compartment_7660", "id": "reaction_10608379", "reactome": "R-DDI-5685242", "name": "CHEK1 phosphorylates BRCA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10608374" ], "products": [ "species_113582", "species_10608377" ], "modifiers": [ [ "species_10577605", "catalyst" ] ], "additional_components": [ "DDB_G0293414", "DDB_G0293414", "DDB_G0279719" ] }, "reaction_10608473": { "compartment": "compartment_7660", "id": "reaction_10608473", "reactome": "R-DDI-5685994", "name": "Long-range resection of DNA DSBs by EXO1 or DNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10608468" ], "products": [ "species_30555", "species_10608470" ], "modifiers": [ [ "species_10608468", "catalyst" ] ], "additional_components": [ "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54EK9", "DDB_G0291466", "Q86IV6", "DDB_G0274777", "Q54Q57", "DDB_G0284153", "Q54DM3", "DDB_G0292130", "Q54GC4", "DDB_G0290275", "Q8T2T7", "DDB_G0275257", "Q54ED2", "DDB_G0291570", "Q54LI7", "DDB_G0286621", "Q86IV6", "DDB_G0274777", "Q54Q57", "DDB_G0284153", "Q54DM3", "DDB_G0292130", "Q54GC4", "DDB_G0290275", "Q8T2T7", "DDB_G0275257", "Q54ED2", "DDB_G0291570", "Q54EK9", "DDB_G0291466", "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54LI7", "DDB_G0286621", "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54EK9", "DDB_G0291466", "Q86IV6", "DDB_G0274777", "Q54Q57", "DDB_G0284153", "Q54DM3", "DDB_G0292130", "Q54GC4", "DDB_G0290275", "Q8T2T7", "DDB_G0275257", "Q54ED2", "DDB_G0291570", "Q54LI7", "DDB_G0286621" ] }, "reaction_10581776": { "compartment": "compartment_7660", "id": "reaction_10581776", "reactome": "R-DDI-75998", "name": "Formation of RAD52 heptameric ring structure complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581772" ], "products": [ "species_10581774" ], "modifiers": [], "additional_components": [ "DDB_G0269406", "Q55E38", "DDB_G0269406" ] }, "reaction_10612584": { "compartment": "compartment_7660", "id": "reaction_10612584", "reactome": "R-DDI-6785594", "name": "FANCD2 binds FANCI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612575", "species_10612580" ], "products": [ "species_10612582" ], "modifiers": [], "additional_components": [ "DDB_G0268216", "DDB_G0293476", "Q54BR4", "DDB_G0293476", "Q55F81", "DDB_G0268216" ] }, "reaction_10582999": { "compartment": "compartment_70101", "id": "reaction_10582999", "reactome": "R-DDI-111925", "name": "cAMP induces dissociation of inactive PKA tetramers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582995" ], "products": [ "species_10582991", "species_10582997" ], "modifiers": [], "additional_components": [ "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029", "P05987", "DDB_G0279413", "Q8MM62", "DDB_G0276027", "species_30389", "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029", "species_30389", "P05987", "DDB_G0279413", "Q8MM62", "DDB_G0276027" ] }, "reaction_10611073": { "compartment": "compartment_70101", "id": "reaction_10611073", "reactome": "R-DDI-5690808", "name": "UCHL3, SENP8 cleave NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10611064" ], "products": [ "species_10611070", "species_10611068" ], "modifiers": [ [ "species_10611064", "catalyst" ] ], "additional_components": [ "Q54T48", "DDB_G0282007", "Q54XV3", "DDB_G0278711", "DDB_G0278711", "Q54T48", "DDB_G0282007", "Q54XV3", "DDB_G0278711", "Q54T48", "DDB_G0282007", "Q54XV3", "DDB_G0278711" ] }, "reaction_10623717": { "compartment": "compartment_70101", "id": "reaction_10623717", "reactome": "R-DDI-8952618", "name": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623697" ], "products": [ "species_10623709", "species_10623518" ], "modifiers": [ [ "species_10623697", "catalyst" ], [ "species_10623715", "inhibitor" ] ], "additional_components": [ "Q54XV3", "DDB_G0278711", "Q54TI6", "DDB_G0281725", "Q54GP1", "DDB_G0290025", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q54GP1", "DDB_G0290025", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54XV3", "DDB_G0278711", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "DDB_G0281725", "Q54XV3", "DDB_G0278711", "Q54TI6", "DDB_G0281725", "Q54GP1", "DDB_G0290025", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q54GP1", "DDB_G0290025", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813" ] }, "reaction_10624069": { "compartment": "compartment_7660", "id": "reaction_10624069", "reactome": "R-DDI-8956045", "name": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623818" ], "products": [ "species_10624064", "species_10624066" ], "modifiers": [ [ "species_10611193", "catalyst" ] ], "additional_components": [ "Q54MP2", "DDB_G0285813", "Q54DR0", "DDB_G0292074", "Q54XV3", "DDB_G0278711", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54E28", "DDB_G0291832", "Q551N8", "DDB_G0276481", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54IY4", "DDB_G0288453", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q55DE3", "DDB_G0269686", "Q54MH6", "DDB_G0285847", "Q552R1", "DDB_G0275925", "Q54K33", "DDB_G0287629", "DDB_G0278711", "Q54MP2", "DDB_G0285813", "Q54DR0", "DDB_G0292074", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54E28", "DDB_G0291832", "Q551N8", "DDB_G0276481", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54IY4", "DDB_G0288453", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q55DE3", "DDB_G0269686", "Q54MH6", "DDB_G0285847", "Q552R1", "DDB_G0275925", "Q54K33", "DDB_G0287629", "Q54PF3", "DDB_G0284597", "Q54QX3", "DDB_G0283587", "Q54HL6", "DDB_G0289361", "Q55BD5", "DDB_G0271282", "Q54E53", "DDB_G0291848", "Q54C92", "DDB_G0293180", "Q75K24", "DDB_G0275471", "Q54B82", "DDB_G0293844" ] }, "reaction_10623720": { "compartment": "compartment_70101", "id": "reaction_10623720", "reactome": "R-DDI-8952620", "name": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623695", "species_10623652", "species_10623542" ], "products": [ "species_10623697" ], "modifiers": [], "additional_components": [ "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q54GP1", "DDB_G0290025", "Q54XV3", "DDB_G0278711", "Q54TI6", "DDB_G0281725", "Q54XV3", "DDB_G0278711", "Q54TI6", "DDB_G0281725", "Q54GP1", "DDB_G0290025", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813" ] }, "reaction_10623656": { "compartment": "compartment_70101", "id": "reaction_10623656", "reactome": "R-DDI-8952039", "name": "NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623629", "species_10623576", "species_10623652" ], "products": [ "species_10623654" ], "modifiers": [], "additional_components": [ "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q9XZJ3", "DDB_G0267384", "O60999", "DDB_G0291972", "Q54XF7", "DDB_G0278991", "Q54J43", "DDB_G0288307", "Q54X83", "DDB_G0279139", "Q54Q05", "DDB_G0284201", "Q54K33", "DDB_G0287629", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "Q54XV3", "DDB_G0278711", "Q54GP1", "DDB_G0290025", "Q54GP1", "DDB_G0290025", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "Q54XV3", "DDB_G0278711", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q9XZJ3", "DDB_G0267384", "O60999", "DDB_G0291972", "Q54XF7", "DDB_G0278991", "Q54J43", "DDB_G0288307", "Q54X83", "DDB_G0279139", "Q54Q05", "DDB_G0284201", "Q54K33", "DDB_G0287629" ] }, "reaction_10623977": { "compartment": "compartment_70101", "id": "reaction_10623977", "reactome": "R-DDI-8955241", "name": "CAND1 binds cytosolic CRL E3 ubiquitin ligases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623973", "species_10611216" ], "products": [ "species_10623975" ], "modifiers": [], "additional_components": [ "O60999", "DDB_G0291972", "Q9XZJ3", "DDB_G0267384", "Q54XF7", "DDB_G0278991", "Q54PM1", "DDB_G0284461", "Q54Q05", "DDB_G0284201", "Q54K33", "DDB_G0287629", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54LV9", "DDB_G0286387", "Q55BF8", "DDB_G0271372", "Q54DL2", "DDB_G0292144", "Q54D84", "DDB_G0292436", "Q86AD8", "DDB_G0271500", "Q54XA6", "DDB_G0279093", "Q54NZ5", "DDB_G0284903", "Q54J43", "DDB_G0288307", "Q54X83", "DDB_G0279139", "DDB_G0274167", "Q86KD1", "DDB_G0274167", "O60999", "DDB_G0291972", "Q9XZJ3", "DDB_G0267384", "Q54XF7", "DDB_G0278991", "Q54PM1", "DDB_G0284461", "Q54Q05", "DDB_G0284201", "Q54K33", "DDB_G0287629", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54LV9", "DDB_G0286387", "Q55BF8", "DDB_G0271372", "Q54DL2", "DDB_G0292144", "Q54D84", "DDB_G0292436", "Q86AD8", "DDB_G0271500", "Q54XA6", "DDB_G0279093", "Q54NZ5", "DDB_G0284903", "Q54J43", "DDB_G0288307", "Q54X83", "DDB_G0279139" ] }, "reaction_10623983": { "compartment": "compartment_7660", "id": "reaction_10623983", "reactome": "R-DDI-8955245", "name": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623979", "species_10623754" ], "products": [ "species_10623981" ], "modifiers": [], "additional_components": [ "DDB_G0274167", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54E28", "DDB_G0291832", "Q551N8", "DDB_G0276481", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54IY4", "DDB_G0288453", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q55DE3", "DDB_G0269686", "Q54MH6", "DDB_G0285847", "Q552R1", "DDB_G0275925", "Q54K33", "DDB_G0287629", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54E28", "DDB_G0291832", "Q551N8", "DDB_G0276481", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54IY4", "DDB_G0288453", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q55DE3", "DDB_G0269686", "Q54MH6", "DDB_G0285847", "Q552R1", "DDB_G0275925", "Q54K33", "DDB_G0287629", "Q86KD1", "DDB_G0274167" ] }, "reaction_10623823": { "compartment": "compartment_7660", "id": "reaction_10623823", "reactome": "R-DDI-8952639", "name": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623726", "species_10623780", "species_10623792" ], "products": [ "species_10623794" ], "modifiers": [], "additional_components": [ "Q54XV3", "DDB_G0278711", "Q54TI6", "DDB_G0281725", "Q54MP2", "DDB_G0285813", "Q54DR0", "DDB_G0292074", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54E28", "DDB_G0291832", "Q551N8", "DDB_G0276481", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54IY4", "DDB_G0288453", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q55DE3", "DDB_G0269686", "Q54MH6", "DDB_G0285847", "Q552R1", "DDB_G0275925", "Q54K33", "DDB_G0287629", "Q54MP2", "DDB_G0285813", "Q54DR0", "DDB_G0292074", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54E28", "DDB_G0291832", "Q551N8", "DDB_G0276481", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54IY4", "DDB_G0288453", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q55DE3", "DDB_G0269686", "Q54MH6", "DDB_G0285847", "Q552R1", "DDB_G0275925", "Q54K33", "DDB_G0287629", "Q54XV3", "DDB_G0278711", "Q54TI6", "DDB_G0281725" ] }, "reaction_10623821": { "compartment": "compartment_7660", "id": "reaction_10623821", "reactome": "R-DDI-8952638", "name": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623794" ], "products": [ "species_10623818", "species_10623796" ], "modifiers": [ [ "species_10623794", "catalyst" ] ], "additional_components": [ "Q54MP2", "DDB_G0285813", "Q54DR0", "DDB_G0292074", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54E28", "DDB_G0291832", "Q551N8", "DDB_G0276481", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54IY4", "DDB_G0288453", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q55DE3", "DDB_G0269686", "Q54MH6", "DDB_G0285847", "Q552R1", "DDB_G0275925", "Q54K33", "DDB_G0287629", "Q54XV3", "DDB_G0278711", "Q54TI6", "DDB_G0281725", "Q54MP2", "DDB_G0285813", "Q54DR0", "DDB_G0292074", "Q54XV3", "DDB_G0278711", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54E28", "DDB_G0291832", "Q551N8", "DDB_G0276481", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54IY4", "DDB_G0288453", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q55DE3", "DDB_G0269686", "Q54MH6", "DDB_G0285847", "Q552R1", "DDB_G0275925", "Q54K33", "DDB_G0287629", "DDB_G0281725", "Q54MP2", "DDB_G0285813", "Q54DR0", "DDB_G0292074", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54E28", "DDB_G0291832", "Q551N8", "DDB_G0276481", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54IY4", "DDB_G0288453", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q55DE3", "DDB_G0269686", "Q54MH6", "DDB_G0285847", "Q552R1", "DDB_G0275925", "Q54K33", "DDB_G0287629", "Q54XV3", "DDB_G0278711", "Q54TI6", "DDB_G0281725" ] }, "reaction_10623985": { "compartment": "compartment_7660", "id": "reaction_10623985", "reactome": "R-DDI-8955285", "name": "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623981", "species_10623778" ], "products": [ "species_10623979", "species_10623780" ], "modifiers": [], "additional_components": [ "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54E28", "DDB_G0291832", "Q551N8", "DDB_G0276481", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54IY4", "DDB_G0288453", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q55DE3", "DDB_G0269686", "Q54MH6", "DDB_G0285847", "Q552R1", "DDB_G0275925", "Q54K33", "DDB_G0287629", "Q86KD1", "DDB_G0274167", "Q54MP2", "DDB_G0285813", "Q54DR0", "DDB_G0292074", "DDB_G0274167", "Q54MP2", "DDB_G0285813", "Q54DR0", "DDB_G0292074", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54E28", "DDB_G0291832", "Q551N8", "DDB_G0276481", "Q54MK9", "DDB_G0285955", "Q7KWL3", "DDB_G0276815", "Q54IY4", "DDB_G0288453", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q55DE3", "DDB_G0269686", "Q54MH6", "DDB_G0285847", "Q552R1", "DDB_G0275925", "Q54K33", "DDB_G0287629" ] }, "reaction_10624084": { "compartment": "compartment_70101", "id": "reaction_10624084", "reactome": "R-DDI-8956099", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624075", "species_10624080" ], "products": [ "species_10624082" ], "modifiers": [], "additional_components": [ "Q54K33", "DDB_G0287629", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q54Q05", "DDB_G0284201", "O60999", "DDB_G0291972", "Q54XF7", "DDB_G0278991", "Q9XZJ3", "DDB_G0267384", "Q54XV3", "DDB_G0278711", "DDB_G0270358", "Q55BU7", "DDB_G0270358", "Q54K33", "DDB_G0287629", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q54Q05", "DDB_G0284201", "O60999", "DDB_G0291972", "Q54XF7", "DDB_G0278991", "Q9XZJ3", "DDB_G0267384", "Q54XV3", "DDB_G0278711" ] }, "reaction_10624090": { "compartment": "compartment_876", "id": "reaction_10624090", "reactome": "R-DDI-8956200", "name": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623695", "species_10623713" ], "products": [ "species_10623715" ], "modifiers": [], "additional_components": [ "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "DDB_G0290025", "Q54GP1", "DDB_G0290025", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813" ] }, "reaction_10623515": { "compartment": "compartment_70101", "id": "reaction_10623515", "reactome": "R-DDI-8951644", "name": "Release of mature NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611068" ], "products": [ "species_10611066", "species_10610849" ], "modifiers": [], "additional_components": [ "Q54T48", "DDB_G0282007", "Q54XV3", "DDB_G0278711", "DDB_G0278711", "DDB_G0282007" ] }, "reaction_10623993": { "compartment": "compartment_70101", "id": "reaction_10623993", "reactome": "R-DDI-8955289", "name": "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623627", "species_10623975" ], "products": [ "species_10623991", "species_10611216" ], "modifiers": [], "additional_components": [ "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q86KD1", "DDB_G0274167", "O60999", "DDB_G0291972", "Q9XZJ3", "DDB_G0267384", "Q54XF7", "DDB_G0278991", "Q54PM1", "DDB_G0284461", "Q54Q05", "DDB_G0284201", "Q54K33", "DDB_G0287629", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54LV9", "DDB_G0286387", "Q55BF8", "DDB_G0271372", "Q54DL2", "DDB_G0292144", "Q54D84", "DDB_G0292436", "Q86AD8", "DDB_G0271500", "Q54XA6", "DDB_G0279093", "Q54NZ5", "DDB_G0284903", "Q54J43", "DDB_G0288307", "Q54X83", "DDB_G0279139", "O60999", "DDB_G0291972", "Q9XZJ3", "DDB_G0267384", "Q54XF7", "DDB_G0278991", "Q54PM1", "DDB_G0284461", "Q54Q05", "DDB_G0284201", "Q54K33", "DDB_G0287629", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q54LV9", "DDB_G0286387", "Q55BF8", "DDB_G0271372", "Q54DL2", "DDB_G0292144", "Q54D84", "DDB_G0292436", "Q86AD8", "DDB_G0271500", "Q54XA6", "DDB_G0279093", "Q54NZ5", "DDB_G0284903", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54J43", "DDB_G0288307", "Q54X83", "DDB_G0279139", "DDB_G0274167" ] }, "reaction_10624062": { "compartment": "compartment_70101", "id": "reaction_10624062", "reactome": "R-DDI-8956040", "name": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624049" ], "products": [ "species_10611066", "species_10624059" ], "modifiers": [ [ "species_10619704", "catalyst" ] ], "additional_components": [ "Q54Q05", "DDB_G0284201", "Q54K33", "DDB_G0287629", "Q54PM1", "DDB_G0284461", "O60999", "DDB_G0291972", "Q54XF7", "DDB_G0278991", "Q9XZJ3", "DDB_G0267384", "Q54XV3", "DDB_G0278711", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q54LV9", "DDB_G0286387", "Q55BF8", "DDB_G0271372", "Q54DL2", "DDB_G0292144", "Q54D84", "DDB_G0292436", "Q86AD8", "DDB_G0271500", "Q54XA6", "DDB_G0279093", "Q54NZ5", "DDB_G0284903", "Q54GP1", "DDB_G0290025", "Q54J43", "DDB_G0288307", "Q54X83", "DDB_G0279139", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "DDB_G0278711", "Q54GP1", "DDB_G0290025", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q54LV9", "DDB_G0286387", "Q55BF8", "DDB_G0271372", "Q54DL2", "DDB_G0292144", "Q54D84", "DDB_G0292436", "Q86AD8", "DDB_G0271500", "Q54XA6", "DDB_G0279093", "Q54NZ5", "DDB_G0284903", "Q9XZJ3", "DDB_G0267384", "Q54XF7", "DDB_G0278991", "Q54PM1", "DDB_G0284461", "Q54Q05", "DDB_G0284201", "Q54J43", "DDB_G0288307", "Q54X83", "DDB_G0279139", "Q75K24", "DDB_G0275471", "Q54C92", "DDB_G0293180", "Q54QX3", "DDB_G0283587", "Q55BD5", "DDB_G0271282", "Q54E53", "DDB_G0291848", "Q54HL6", "DDB_G0289361", "Q54PF3", "DDB_G0284597", "Q54B82", "DDB_G0293844" ] }, "reaction_10623679": { "compartment": "compartment_70101", "id": "reaction_10623679", "reactome": "R-DDI-8952044", "name": "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623654" ], "products": [ "species_10623676", "species_10623557" ], "modifiers": [ [ "species_10623654", "catalyst" ] ], "additional_components": [ "Q54GP1", "DDB_G0290025", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "Q54XV3", "DDB_G0278711", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q9XZJ3", "DDB_G0267384", "O60999", "DDB_G0291972", "Q54XF7", "DDB_G0278991", "Q54J43", "DDB_G0288307", "Q54X83", "DDB_G0279139", "Q54Q05", "DDB_G0284201", "Q54K33", "DDB_G0287629", "Q54GP1", "DDB_G0290025", "Q54J43", "DDB_G0288307", "Q54X83", "DDB_G0279139", "Q54Q05", "DDB_G0284201", "Q54K33", "DDB_G0287629", "Q54XF7", "DDB_G0278991", "Q9XZJ3", "DDB_G0267384", "O60999", "DDB_G0291972", "Q54XV3", "DDB_G0278711", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q94490", "DDB_G0284865", "Q54J12", "DDB_G0288697", "Q54IK3", "DDB_G0288697", "Q54GP1", "DDB_G0290025", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "Q54XV3", "DDB_G0278711", "Q54DR0", "DDB_G0292074", "Q54MP2", "DDB_G0285813", "Q9XZJ3", "DDB_G0267384", "O60999", "DDB_G0291972", "Q54XF7", "DDB_G0278991", "Q54J43", "DDB_G0288307", "Q54X83", "DDB_G0279139", "Q54Q05", "DDB_G0284201", "Q54K33", "DDB_G0287629" ] }, "reaction_10585332": { "compartment": "compartment_70101", "id": "reaction_10585332", "reactome": "R-DDI-174070", "name": "Association of Cdh1 with the APC/C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577382", "species_10577377" ], "products": [ "species_10577384" ], "modifiers": [], "additional_components": [ "DDB_G0287259", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54KM3", "DDB_G0287259" ] }, "reaction_10585450": { "compartment": "compartment_70101", "id": "reaction_10585450", "reactome": "R-DDI-174224", "name": "Dissociation of Cdc20 from APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585386" ], "products": [ "species_10583643", "species_10577377" ], "modifiers": [], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54MZ3", "DDB_G0285601", "DDB_G0285601", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021" ] }, "reaction_10587270": { "compartment": "compartment_7660", "id": "reaction_10587270", "reactome": "R-DDI-199839", "name": "AKT can phosphorylate RSK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10587243" ], "products": [ "species_113582", "species_10587247" ], "modifiers": [ [ "species_10587267", "catalyst" ] ], "additional_components": [ "DDB_G0277449", "DDB_G0277449", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795" ] }, "reaction_10603208": { "compartment": "compartment_7660", "id": "reaction_10603208", "reactome": "R-DDI-3788705", "name": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10585338" ], "products": [ "species_113582", "species_10585340" ], "modifiers": [ [ "species_10585338", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "P34112", "DDB_G0272813", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "P34112", "DDB_G0272813", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259" ] }, "reaction_10603227": { "compartment": "compartment_7660", "id": "reaction_10603227", "reactome": "R-DDI-3788724", "name": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603218", "species_10576865" ], "products": [ "species_10603224" ], "modifiers": [ [ "species_10603218", "catalyst" ] ], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259" ] }, "reaction_10603210": { "compartment": "compartment_7660", "id": "reaction_10603210", "reactome": "R-DDI-3788708", "name": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585336", "species_10576705" ], "products": [ "species_10585338" ], "modifiers": [], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "P34112", "DDB_G0272813", "P34112", "DDB_G0272813", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259" ] }, "reaction_10598257": { "compartment": "compartment_70101", "id": "reaction_10598257", "reactome": "R-DDI-1483222", "name": "ETA is phosphorylated to PETA by CHK/ETNK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1498751" ], "products": [ "species_29370", "species_428686" ], "modifiers": [ [ "species_10598254", "catalyst" ] ], "additional_components": [ "Q554D8", "DDB_G0275265", "Q869T9", "DDB_G0274955" ] }, "reaction_10598075": { "compartment": "compartment_12045", "id": "reaction_10598075", "reactome": "R-DDI-1482962", "name": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500603", "species_1500596" ], "products": [ "species_1500581", "species_109395" ], "modifiers": [ [ "species_10598072", "catalyst" ] ], "additional_components": [ "Q8T2Q6", "DDB_G0275235", "Q54XM0", "DDB_G0278947", "Q550W1", "DDB_G0276763", "Q55AQ3", "DDB_G0271794", "species_29926", "species_266099" ] }, "reaction_10598234": { "compartment": "compartment_12045", "id": "reaction_10598234", "reactome": "R-DDI-1483203", "name": "PA is dephosphorylated to DAG by LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426755" ], "products": [ "species_29372", "species_1500596" ], "modifiers": [ [ "species_10598231", "catalyst" ] ], "additional_components": [ "Q75JA1", "DDB_G0271730", "species_29926" ] }, "reaction_10598223": { "compartment": "compartment_12045", "id": "reaction_10598223", "reactome": "R-DDI-1483190", "name": "PETA and CTP are condensed to CDP-ETA by PCY2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428686", "species_110614" ], "products": [ "species_111294", "species_1500603" ], "modifiers": [ [ "species_10598220", "catalyst" ] ], "additional_components": [ "Q55BZ4", "DDB_G0270298" ] }, "reaction_10583607": { "compartment": "compartment_70101", "id": "reaction_10583607", "reactome": "R-DDI-141186", "name": "MAOA:FAD oxidatively deaminates of 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_209914", "species_29368" ], "products": [ "species_500604", "species_29382", "species_29408" ], "modifiers": [ [ "species_10583604", "catalyst" ] ], "additional_components": [ "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10589900": { "compartment": "compartment_5460", "id": "reaction_10589900", "reactome": "R-DDI-380608", "name": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_380598" ], "products": [ "species_113529", "species_380593", "species_29362" ], "modifiers": [ [ "species_10578724", "catalyst" ] ], "additional_components": [ "Q54FY3", "DDB_G0290479" ] }, "reaction_10583105": { "compartment": "compartment_70101", "id": "reaction_10583105", "reactome": "R-DDI-112037", "name": "Inactivation of PLC beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10582955" ], "products": [ "species_10583103", "species_29372", "species_10582859" ], "modifiers": [], "additional_components": [ "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438", "Q02158", "DDB_G0292736", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29420", "DDB_G0292736" ] }, "reaction_10592511": { "compartment": "compartment_70101", "id": "reaction_10592511", "reactome": "R-DDI-442749", "name": "CaMKK autophosphorylates in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10592503" ], "products": [ "species_113582", "species_10592508" ], "modifiers": [ [ "species_10592503", "catalyst" ] ], "additional_components": [ "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "species_74112", "Q55CW1", "DDB_G0270680", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "species_74112", "Q55CW1", "DDB_G0270680", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "species_74112", "Q55CW1", "DDB_G0270680" ] }, "reaction_10583076": { "compartment": "compartment_70101", "id": "reaction_10583076", "reactome": "R-DDI-111955", "name": "cAMP hydrolysis by Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10583073", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121" ] }, "reaction_10583078": { "compartment": "compartment_70101", "id": "reaction_10583078", "reactome": "R-DDI-111956", "name": "Calmodulin activates Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583073" ], "products": [ "species_10583073" ], "modifiers": [ [ "species_10583042", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121", "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917" ] }, "reaction_10583044": { "compartment": "compartment_876", "id": "reaction_10583044", "reactome": "R-DDI-111930", "name": "Adenylate cyclase produces cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_111294", "species_30389" ], "modifiers": [ [ "species_10583022", "catalyst" ], [ "species_10583042", "catalyst" ] ], "additional_components": [ "species_29926", "Q03100", "DDB_G0281545", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917" ] }, "reaction_10623546": { "compartment": "compartment_70101", "id": "reaction_10623546", "reactome": "R-DDI-8951727", "name": "cAMP binds PKA tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10582993" ], "products": [ "species_10582995" ], "modifiers": [], "additional_components": [ "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029", "P05987", "DDB_G0279413", "Q8MM62", "DDB_G0276027", "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029", "P05987", "DDB_G0279413", "Q8MM62", "DDB_G0276027", "species_30389" ] }, "reaction_10582958": { "compartment": "compartment_70101", "id": "reaction_10582958", "reactome": "R-DDI-111879", "name": "PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10582955", "catalyst" ] ], "additional_components": [ "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438", "Q02158", "DDB_G0292736" ] }, "reaction_10577793": { "compartment": "compartment_70101", "id": "reaction_10577793", "reactome": "R-DDI-70486", "name": "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29728" ], "products": [ "species_29370", "species_29800" ], "modifiers": [ [ "species_10577790", "catalyst" ] ], "additional_components": [ "species_29926", "Q9GPM4", "DDB_G0287595" ] }, "reaction_10589604": { "compartment": "compartment_70101", "id": "reaction_10589604", "reactome": "R-DDI-372843", "name": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_113544" ], "products": [ "species_113548", "species_198498" ], "modifiers": [ [ "species_10589601", "catalyst" ] ], "additional_components": [ "DDB_G0284225" ] }, "reaction_10586982": { "compartment": "compartment_70101", "id": "reaction_10586982", "reactome": "R-DDI-198508", "name": "malate + NAD+ <=> oxaloacetate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198498", "species_29360" ], "products": [ "species_70106", "species_76213", "species_73473" ], "modifiers": [ [ "species_10586979", "catalyst" ] ], "additional_components": [ "Q54GE6", "DDB_G0290207" ] }, "reaction_10577773": { "compartment": "compartment_70101", "id": "reaction_10577773", "reactome": "R-DDI-70479", "name": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30014", "species_29356" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10577770", "catalyst" ], [ "species_76577", "inhibitor" ] ], "additional_components": [ "Q6RYT0", "DDB_G0270836", "species_29926" ] }, "reaction_10589548": { "compartment": "compartment_70101", "id": "reaction_10589548", "reactome": "R-DDI-372448", "name": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_113553" ], "products": [ "species_29448", "species_113552" ], "modifiers": [ [ "species_10589543", "catalyst" ] ], "additional_components": [ "DDB_G0283329" ] }, "reaction_10589775": { "compartment": "compartment_70101", "id": "reaction_10589775", "reactome": "R-DDI-376851", "name": "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_198498" ], "products": [ "species_29406", "species_113544" ], "modifiers": [ [ "species_10586969", "catalyst" ] ], "additional_components": [ "Q54PY7", "DDB_G0284225" ] }, "reaction_10577775": { "compartment": "compartment_70101", "id": "reaction_10577775", "reactome": "R-DDI-70481", "name": "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29578" ], "products": [ "species_75970" ], "modifiers": [ [ "species_10577742", "catalyst" ] ], "additional_components": [ "Q869R8", "DDB_G0274471" ] }, "reaction_10577777": { "compartment": "compartment_70101", "id": "reaction_10577777", "reactome": "R-DDI-70482", "name": "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29800", "species_73473" ], "products": [ "species_29372", "species_29578", "species_29360" ], "modifiers": [ [ "species_10577732", "catalyst" ] ], "additional_components": [ "Q94469", "DDB_G0275153" ] }, "reaction_10578553": { "compartment": "compartment_70101", "id": "reaction_10578553", "reactome": "R-DDI-71445", "name": "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30485" ], "products": [ "species_29728" ], "modifiers": [ [ "species_10578550", "catalyst" ] ], "additional_components": [ "Q54NE6", "DDB_G0285311" ] }, "reaction_10577757": { "compartment": "compartment_70101", "id": "reaction_10577757", "reactome": "R-DDI-70475", "name": "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10577752", "catalyst" ] ], "additional_components": [ "Q5V9E9", "DDB_G0283673" ] }, "reaction_10586972": { "compartment": "compartment_70101", "id": "reaction_10586972", "reactome": "R-DDI-198440", "name": "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_113544" ], "products": [ "species_113594", "species_198498" ], "modifiers": [ [ "species_10586969", "catalyst" ] ], "additional_components": [ "Q54PY7", "DDB_G0284225" ] }, "reaction_10577628": { "compartment": "compartment_70101", "id": "reaction_10577628", "reactome": "R-DDI-70241", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_76213" ], "products": [ "species_29420", "species_113528", "species_29492" ], "modifiers": [ [ "species_10577625", "catalyst" ] ], "additional_components": [ "DDB_G0271904" ] }, "reaction_10577820": { "compartment": "compartment_70101", "id": "reaction_10577820", "reactome": "R-DDI-70494", "name": "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29492" ], "products": [ "species_30485" ], "modifiers": [ [ "species_10577817", "catalyst" ] ], "additional_components": [ "Q54RK5", "DDB_G0283137", "Q55F83", "DDB_G0268214", "species_29926" ] }, "reaction_10578556": { "compartment": "compartment_70101", "id": "reaction_10578556", "reactome": "R-DDI-71495", "name": "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29578", "species_75970" ], "products": [ "species_30014" ], "modifiers": [ [ "species_10577690", "catalyst" ] ], "additional_components": [ "Q86A67", "DDB_G0274375" ] }, "reaction_10589599": { "compartment": "compartment_5460", "id": "reaction_10589599", "reactome": "R-DDI-372819", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113573", "species_113587" ], "products": [ "species_372364", "species_113525", "species_29376" ], "modifiers": [ [ "species_10589596", "catalyst" ] ], "additional_components": [ "DDB_G0271904" ] }, "reaction_10577886": { "compartment": "compartment_5460", "id": "reaction_10577886", "reactome": "R-DDI-70613", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113587", "species_113552" ], "products": [ "species_113594", "species_113553" ], "modifiers": [ [ "species_10577869", "catalyst" ] ], "additional_components": [ "Q55F21", "DDB_G0268664" ] }, "reaction_10602325": { "compartment": "compartment_70101", "id": "reaction_10602325", "reactome": "R-DDI-3249379", "name": "p-S407-STAT6 is phosphorylated at Tyr641", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10602323" ], "products": [ "species_29370", "species_10602295" ], "modifiers": [], "additional_components": [ "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10602311": { "compartment": "compartment_70101", "id": "reaction_10602311", "reactome": "R-DDI-3249370", "name": "p-S407,Y641-STAT6 dimer migrates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602297" ], "products": [ "species_10602309" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638" ] }, "reaction_10602313": { "compartment": "compartment_70101", "id": "reaction_10602313", "reactome": "R-DDI-3249372", "name": "p-S407,Y641-STAT6 is dimerized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602295" ], "products": [ "species_10602297" ], "modifiers": [], "additional_components": [ "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532", "Q70GP4", "DDB_G0268638", "Q86I20", "DDB_G0275167", "O00910", "DDB_G0281381", "Q54BD4", "DDB_G0293532" ] }, "reaction_10597394": { "compartment": "compartment_876", "id": "reaction_10597394", "reactome": "R-DDI-1296348", "name": "Activation of TWIK-related K+ channel (TREK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10597391", "catalyst" ] ], "additional_components": [ "Q86K40", "DDB_G0277255", "Q8T268", "DDB_G0277255" ] }, "reaction_10598007": { "compartment": "compartment_12045", "id": "reaction_10598007", "reactome": "R-DDI-1482816", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[6]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10598004", "catalyst" ] ], "additional_components": [ "DDB_G0283551" ] }, "reaction_10597944": { "compartment": "compartment_12045", "id": "reaction_10597944", "reactome": "R-DDI-1482547", "name": "1-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524028", "species_1500578" ], "products": [ "species_426925", "species_76194" ], "modifiers": [ [ "species_10597927", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541", "Q54X10", "DDB_G0279277" ] }, "reaction_10597930": { "compartment": "compartment_12045", "id": "reaction_10597930", "reactome": "R-DDI-1482533", "name": "2-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_975614" ], "products": [ "species_426925", "species_76194" ], "modifiers": [ [ "species_10597927", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541", "Q54X10", "DDB_G0279277" ] }, "reaction_10621983": { "compartment": "compartment_12045", "id": "reaction_10621983", "reactome": "R-DDI-8874435", "name": "THEM86B hydrolyses PMCHO, PMETAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8874447" ], "products": [ "species_8874450", "species_5696116" ], "modifiers": [ [ "species_10621980", "catalyst" ] ], "additional_components": [ "CHEBI:17810", "CHEBI:17476", "CHEBI:36313", "CHEBI:36314", "DDB_G0275665" ] }, "reaction_10598014": { "compartment": "compartment_12045", "id": "reaction_10598014", "reactome": "R-DDI-1482856", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[5]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10597959", "catalyst" ] ], "additional_components": [ "DDB_G0284449" ] }, "reaction_10582832": { "compartment": "compartment_7660", "id": "reaction_10582832", "reactome": "R-DDI-111437", "name": "Cleavage of the 3'-end of the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582828" ], "products": [ "species_10582830", "species_10582465" ], "modifiers": [], "additional_components": [ "Q55A45", "DDB_G0272320", "C7G054", "DDB_G0302414", "Q86L45", "DDB_G0273003", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q54RX0", "DDB_G0282863", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q55A45", "DDB_G0272320", "C7G054", "DDB_G0302414", "Q86L45", "DDB_G0273003", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q54RX0", "DDB_G0282863" ] }, "reaction_10582834": { "compartment": "compartment_7660", "id": "reaction_10582834", "reactome": "R-DDI-111438", "name": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582432", "species_10582465" ], "products": [ "species_10582828" ], "modifiers": [], "additional_components": [ "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q55A45", "DDB_G0272320", "C7G054", "DDB_G0302414", "Q86L45", "DDB_G0273003", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "C7G054", "DDB_G0302414", "Q86L45", "DDB_G0273003", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q54RX0", "DDB_G0282863", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197" ] }, "reaction_10627229": { "compartment": "compartment_7660", "id": "reaction_10627229", "reactome": "R-DDI-9671145", "name": "DKC1 binds SHQ1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627225", "species_10584005" ], "products": [ "species_10627227" ], "modifiers": [], "additional_components": [ "DDB_G0269304", "DDB_G0281933", "Q54T81", "DDB_G0281933", "Q55EC4", "DDB_G0269304" ] }, "reaction_10600850": { "compartment": "compartment_7660", "id": "reaction_10600850", "reactome": "R-DDI-2294580", "name": "PLK1 hyperphosphorylates Condensin II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10600834" ], "products": [ "species_113582", "species_10600847" ], "modifiers": [ [ "species_10600834", "catalyst" ] ], "additional_components": [ "Q86HN7", "DDB_G0274503", "Q76NW2", "DDB_G0276863", "Q54PK4", "DDB_G0284499", "Q54ID6", "DDB_G0288819", "Q54DZ9", "DDB_G0291894", "Q54LV0", "DDB_G0286403", "Q54XY3", "DDB_G0278701", "Q86HN7", "DDB_G0274503", "Q76NW2", "DDB_G0276863", "Q54PK4", "DDB_G0284499", "Q54XY3", "DDB_G0278701", "Q54ID6", "DDB_G0288819", "Q54DZ9", "DDB_G0291894", "Q54LV0", "DDB_G0286403", "Q86HN7", "DDB_G0274503", "Q76NW2", "DDB_G0276863", "Q54PK4", "DDB_G0284499", "Q54ID6", "DDB_G0288819", "Q54DZ9", "DDB_G0291894", "Q54LV0", "DDB_G0286403", "Q54XY3", "DDB_G0278701" ] }, "reaction_10600854": { "compartment": "compartment_7660", "id": "reaction_10600854", "reactome": "R-DDI-2294590", "name": "PLK1 binds phosphorylated condensin II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600852", "species_10583697" ], "products": [ "species_10600834" ], "modifiers": [], "additional_components": [ "Q54PK4", "DDB_G0284499", "Q54ID6", "DDB_G0288819", "Q54DZ9", "DDB_G0291894", "Q54LV0", "DDB_G0286403", "Q54XY3", "DDB_G0278701", "Q76NW2", "DDB_G0276863", "DDB_G0274503", "Q86HN7", "DDB_G0274503", "Q76NW2", "DDB_G0276863", "Q54PK4", "DDB_G0284499", "Q54ID6", "DDB_G0288819", "Q54DZ9", "DDB_G0291894", "Q54LV0", "DDB_G0286403", "Q54XY3", "DDB_G0278701" ] }, "reaction_10600826": { "compartment": "compartment_7660", "id": "reaction_10600826", "reactome": "R-DDI-2288097", "name": "Condensin II complex binds H4K20me1-containing nucleosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600587", "species_10600624" ], "products": [ "species_10600824" ], "modifiers": [ [ "species_10600589", "catalyst" ] ], "additional_components": [ "Q54PK4", "DDB_G0284499", "Q54ID6", "DDB_G0288819", "Q54DZ9", "DDB_G0291894", "Q54LV0", "DDB_G0286403", "Q54XY3", "DDB_G0278701", "Q76NW2", "DDB_G0276863", "Q76NW2", "DDB_G0276863", "Q54PK4", "DDB_G0284499", "Q54ID6", "DDB_G0288819", "Q54DZ9", "DDB_G0291894", "Q54LV0", "DDB_G0286403", "Q54XY3", "DDB_G0278701", "Q54FX2", "DDB_G0290551", "Q54PK4", "DDB_G0284499", "Q54ID6", "DDB_G0288819", "Q54DZ9", "DDB_G0291894", "Q54LV0", "DDB_G0286403", "Q54XY3", "DDB_G0278701" ] }, "reaction_10600637": { "compartment": "compartment_7660", "id": "reaction_10600637", "reactome": "R-DDI-2172678", "name": "PHF8 demethylates histone H4K20me1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600630", "species_113671", "species_113685" ], "products": [ "species_10600634", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10600630", "catalyst" ] ], "additional_components": [ "Q76NW2", "DDB_G0276863", "species_71067", "species_71067", "Q76NW2", "DDB_G0276863", "Q76NW2", "DDB_G0276863", "species_71067" ] }, "reaction_10600591": { "compartment": "compartment_7660", "id": "reaction_10600591", "reactome": "R-DDI-2172666", "name": "RB1 binds condensin II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577547", "species_10600587" ], "products": [ "species_10600589" ], "modifiers": [], "additional_components": [ "DDB_G0290551", "Q54PK4", "DDB_G0284499", "Q54ID6", "DDB_G0288819", "Q54DZ9", "DDB_G0291894", "Q54LV0", "DDB_G0286403", "Q54XY3", "DDB_G0278701", "Q54FX2", "DDB_G0290551", "Q54PK4", "DDB_G0284499", "Q54ID6", "DDB_G0288819", "Q54DZ9", "DDB_G0291894", "Q54LV0", "DDB_G0286403", "Q54XY3", "DDB_G0278701" ] }, "reaction_10595203": { "compartment": "compartment_70101", "id": "reaction_10595203", "reactome": "R-DDI-939265", "name": "Activation of Rap1 by membrane-associated GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10589459" ], "products": [ "species_29420", "species_10589457" ], "modifiers": [ [ "species_10590642", "catalyst" ] ], "additional_components": [ "species_29420", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "species_29438", "Q54TK8", "DDB_G0281573", "Q8IS12", "DDB_G0275703" ] }, "reaction_10589538": { "compartment": "compartment_70101", "id": "reaction_10589538", "reactome": "R-DDI-354173", "name": "Activation of Rap1 by cytosolic GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10589459" ], "products": [ "species_29420", "species_10589457" ], "modifiers": [ [ "species_10589535", "catalyst" ] ], "additional_components": [ "species_29420", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "species_29438", "species_74112", "species_6797635", "Q55FD8", "DDB_G0268578", "Q55GH9", "DDB_G0267666", "Q8IS11", "DDB_G0290267", "Q8IS14", "DDB_G0277913", "Q8IS15", "DDB_G0277915", "Q8IS16", "DDB_G0276963", "Q8IS20", "DDB_G0282381", "Q8IS21", "DDB_G0269222", "Q8SSQ0", "DDB_G0274605", "Q8SSW7", "DDB_G0271868", "B0M0P8", "DDB_G0276371", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q54FF3", "DDB_G0290901", "Q54H95", "DDB_G0289613", "Q54PQ4", "DDB_G0284329", "Q54XL4", "DDB_G0289613" ] }, "reaction_10600085": { "compartment": "compartment_12045", "id": "reaction_10600085", "reactome": "R-DDI-2046093", "name": "Translocation of tetracosapentaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046050", "species_211579" ], "products": [ "species_5228339", "species_2046055", "species_211606" ], "modifiers": [ [ "species_10590195", "catalyst" ] ], "additional_components": [ "DDB_G0293194" ] }, "reaction_10600087": { "compartment": "compartment_17957", "id": "reaction_10600087", "reactome": "R-DDI-2046094", "name": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046042", "species_113601" ], "products": [ "species_113519", "species_113564", "species_162743", "species_159751", "species_2046045" ], "modifiers": [ [ "species_10593966", "catalyst" ] ], "additional_components": [ "Q55BY4", "DDB_G0271066", "C7FZW5", "DDB_G0271066" ] }, "reaction_10600071": { "compartment": "compartment_12045", "id": "reaction_10600071", "reactome": "R-DDI-2046083", "name": "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046053", "species_113601" ], "products": [ "species_113519", "species_162743", "species_159751", "species_2046060" ], "modifiers": [ [ "species_10593964", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10600089": { "compartment": "compartment_17957", "id": "reaction_10600089", "reactome": "R-DDI-2046095", "name": "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046060", "species_113601" ], "products": [ "species_2046048", "species_113519", "species_162743", "species_159751" ], "modifiers": [ [ "species_10593964", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10600091": { "compartment": "compartment_12045", "id": "reaction_10600091", "reactome": "R-DDI-2046098", "name": "Activation of linoleic acid to linoleoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211579", "species_162743", "species_2046044" ], "products": [ "species_2046064", "species_2046049", "species_2046063" ], "modifiers": [ [ "species_10600073", "catalyst" ] ], "additional_components": [ "species_29926", "Q54JK0", "DDB_G0288001", "Q55DR6", "DDB_G0269242", "Q1ZXQ4", "DDB_G0269474" ] }, "reaction_10599749": { "compartment": "compartment_20699", "id": "reaction_10599749", "reactome": "R-DDI-2022887", "name": "NDST1-4 N-deacetylates GlcNAc residues in heparan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2022884", "species_10599746" ], "products": [ "species_10599718", "species_2022890" ], "modifiers": [ [ "species_10599730", "catalyst" ] ], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488", "DDB_G0267630" ] }, "reaction_10599739": { "compartment": "compartment_20699", "id": "reaction_10599739", "reactome": "R-DDI-2022860", "name": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10599718" ], "products": [ "species_10599725", "species_742343" ], "modifiers": [ [ "species_10599730", "catalyst" ] ], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488", "DDB_G0267630" ] }, "reaction_10600141": { "compartment": "compartment_20699", "id": "reaction_10600141", "reactome": "R-DDI-2076611", "name": "HS3STs sulfate GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10599765" ], "products": [ "species_10599772", "species_742343" ], "modifiers": [ [ "species_10600128", "catalyst" ] ], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488", "DDB_G0267630" ] }, "reaction_10599821": { "compartment": "compartment_17963", "id": "reaction_10599821", "reactome": "R-DDI-2024108", "name": "Some HSPGs are secreted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599787" ], "products": [ "species_10599819" ], "modifiers": [], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488" ] }, "reaction_10600126": { "compartment": "compartment_17963", "id": "reaction_10600126", "reactome": "R-DDI-2076383", "name": "HS3ST1 sulfates GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10599765" ], "products": [ "species_10599772", "species_742343" ], "modifiers": [ [ "species_10600121", "catalyst" ] ], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488", "DDB_G0267630" ] }, "reaction_10599661": { "compartment": "compartment_20699", "id": "reaction_10599661", "reactome": "R-DDI-1878002", "name": "XYLTs transfer Xyl to core protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599635", "species_742361" ], "products": [ "species_10599642", "species_205687" ], "modifiers": [ [ "species_10599658", "catalyst" ] ], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488", "Q55F91", "DDB_G0269558", "Q55DR5", "DDB_G0269558" ] }, "reaction_10600145": { "compartment": "compartment_161320", "id": "reaction_10600145", "reactome": "R-DDI-2090038", "name": "NAGLU hydrolyses heparan chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090053" ], "products": [ "species_1678743", "species_2065212" ], "modifiers": [ [ "species_10599153", "catalyst" ] ], "additional_components": [ "DDB_G0291998" ] }, "reaction_10600147": { "compartment": "compartment_161320", "id": "reaction_10600147", "reactome": "R-DDI-2090079", "name": "GLB1 hydrolyses linker chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090075" ], "products": [ "species_1605637", "species_2090063" ], "modifiers": [ [ "species_10598338", "catalyst" ] ], "additional_components": [ "DDB_G0290217" ] }, "reaction_10600149": { "compartment": "compartment_17938", "id": "reaction_10600149", "reactome": "R-DDI-2090085", "name": "HGSNAT oligomer acetylates Heparan chain(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183", "species_2090045" ], "products": [ "species_2090053", "species_76194" ], "modifiers": [ [ "species_10599125", "catalyst" ] ], "additional_components": [ "Q54LX9", "DDB_G0286315" ] }, "reaction_10599156": { "compartment": "compartment_161320", "id": "reaction_10599156", "reactome": "R-DDI-1678742", "name": "NAGLU hydrolyses Heparan sulfate chain(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090069" ], "products": [ "species_2090080", "species_1678743" ], "modifiers": [ [ "species_10599153", "catalyst" ] ], "additional_components": [ "DDB_G0291998" ] }, "reaction_10599751": { "compartment": "compartment_876", "id": "reaction_10599751", "reactome": "R-DDI-2024084", "name": "HS-GAGs translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599134" ], "products": [ "species_10598515" ], "modifiers": [], "additional_components": [ "Q55E77", "DDB_G0270488", "Q55E77", "DDB_G0270488" ] }, "reaction_10599128": { "compartment": "compartment_17938", "id": "reaction_10599128", "reactome": "R-DDI-1678660", "name": "HGSNAT oligomer acetylates Heparan sulfate chain(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2090040", "species_76183" ], "products": [ "species_2090069", "species_76194" ], "modifiers": [ [ "species_10599125", "catalyst" ] ], "additional_components": [ "Q54LX9", "DDB_G0286315" ] }, "reaction_10599148": { "compartment": "compartment_161320", "id": "reaction_10599148", "reactome": "R-DDI-1678716", "name": "IDUA hydrolyses Heparan sulfate chain(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2090033", "species_1605715" ], "products": [ "species_2090072", "species_1678617" ], "modifiers": [ [ "species_10599145", "catalyst" ] ], "additional_components": [ "DDB_G0288289" ] }, "reaction_10600143": { "compartment": "compartment_161320", "id": "reaction_10600143", "reactome": "R-DDI-2090037", "name": "IDUA hydrolyses Heparan sulfate chain(6)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090055" ], "products": [ "species_2090070", "species_1678617" ], "modifiers": [ [ "species_10599145", "catalyst" ] ], "additional_components": [ "DDB_G0288289" ] }, "reaction_10593201": { "compartment": "compartment_70101", "id": "reaction_10593201", "reactome": "R-DDI-450358", "name": "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037" ], "products": [ "species_10584754" ], "modifiers": [ [ "species_10593152", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54C11", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "P11467", "DDB_G0290961", "Q86L54", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q54LU8", "DDB_G0286465" ] }, "reaction_10617650": { "compartment": "compartment_12045", "id": "reaction_10617650", "reactome": "R-DDI-6811425", "name": "NSF and SNAPs bind cis-SNARE at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611694", "species_10611703", "species_10617648" ], "products": [ "species_10617536" ], "modifiers": [], "additional_components": [ "Q75JI3", "DDB_G0276153", "Q54NP6", "DDB_G0285111", "Q55CR0", "DDB_G0269942", "Q55GJ4", "DDB_G0267646", "Q54TZ2", "DDB_G0281429", "Q54LH0", "DDB_G0286811", "Q55CR0", "DDB_G0269942", "Q54NP6", "DDB_G0285111", "Q55GJ4", "DDB_G0267646", "Q54TZ2", "DDB_G0281429", "Q54LH0", "DDB_G0286811", "Q75JI3", "DDB_G0276153" ] }, "reaction_10617491": { "compartment": "compartment_20699", "id": "reaction_10617491", "reactome": "R-DDI-6811415", "name": "RAB:GTP recruits GBF1 to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617199", "species_10616771" ], "products": [ "species_10617489" ], "modifiers": [], "additional_components": [ "species_29438", "Q552K3", "DDB_G0275969", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "Q558I0", "DDB_G0272905", "P34141", "DDB_G0291233", "P34140", "DDB_G0277867", "Q54EW9", "DDB_G0291293", "P34143", "DDB_G0271736", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "species_29438", "Q552K3", "DDB_G0275969", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "Q558I0", "DDB_G0272905", "P34141", "DDB_G0291233", "P34140", "DDB_G0277867", "Q54EW9", "DDB_G0291293", "P34143", "DDB_G0271736" ] }, "reaction_10617507": { "compartment": "compartment_20699", "id": "reaction_10617507", "reactome": "R-DDI-6811417", "name": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617503", "species_10616863", "species_10617497", "species_10617495", "species_10617233" ], "products": [ "species_10617505" ], "modifiers": [], "additional_components": [ "Q86JE5", "DDB_G0272124", "Q769F9", "DDB_G0288053", "Q54BN0", "DDB_G0293540", "Q556J9", "DDB_G0272889", "Q769F6", "DDB_G0277923", "Q769F7", "DDB_G0278969", "Q54DK9", "DDB_G0292148", "Q54TP9", "DDB_G0292148", "DDB_G0269942", "species_29438", "Q54X30", "DDB_G0290771", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q552K3", "DDB_G0275969", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "Q558I0", "DDB_G0272905", "P34141", "DDB_G0291233", "P34140", "DDB_G0277867", "Q54EW9", "DDB_G0291293", "P34143", "DDB_G0271736", "Q55EZ6", "DDB_G0268702", "Q23924", "DDB_G0284735", "Q54HL0", "DDB_G0289371", "Q54CA7", "DDB_G0293086", "Q54HD4", "DDB_G0289523", "Q54YD8", "DDB_G0278285", "Q55FU2", "DDB_G0267950", "Q55FR9", "DDB_G0267982", "Q769F9", "DDB_G0288053", "Q54BN0", "DDB_G0293540", "Q769F6", "DDB_G0277923", "Q769F7", "DDB_G0278969", "Q769F9", "DDB_G0288053", "Q54BN0", "DDB_G0293540", "Q769F6", "DDB_G0277923", "Q769F7", "DDB_G0278969", "species_29438", "Q54X30", "DDB_G0290771", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q552K3", "DDB_G0275969", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "Q558I0", "DDB_G0272905", "P34141", "DDB_G0291233", "P34140", "DDB_G0277867", "Q54EW9", "DDB_G0291293", "P34143", "DDB_G0271736", "Q55EZ6", "DDB_G0268702", "Q23924", "DDB_G0284735", "Q54HL0", "DDB_G0289371", "Q54CA7", "DDB_G0293086", "Q54HD4", "DDB_G0289523", "Q54YD8", "DDB_G0278285", "Q55FU2", "DDB_G0267950", "Q55FR9", "DDB_G0267982", "Q55CR0", "DDB_G0269942", "Q54DK9", "DDB_G0292148", "Q54TP9", "DDB_G0292148", "Q86JE5", "DDB_G0272124", "Q556J9", "DDB_G0272889" ] }, "reaction_10617539": { "compartment": "compartment_12045", "id": "reaction_10617539", "reactome": "R-DDI-6811422", "name": "NSF ATPase activity dissociates cis-SNARE at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10617536" ], "products": [ "species_10611694", "species_10617532", "species_29372", "species_10611703", "species_10617527", "species_10587872", "species_10617522" ], "modifiers": [ [ "species_10617536", "catalyst" ] ], "additional_components": [ "Q55CR0", "DDB_G0269942", "Q54NP6", "DDB_G0285111", "Q55GJ4", "DDB_G0267646", "Q54TZ2", "DDB_G0281429", "Q54LH0", "DDB_G0286811", "Q75JI3", "DDB_G0276153", "Q75JI3", "DDB_G0276153", "DDB_G0286811", "Q54NP6", "DDB_G0285111", "DDB_G0281429", "DDB_G0269942", "DDB_G0267646", "Q55CR0", "DDB_G0269942", "Q54NP6", "DDB_G0285111", "Q55GJ4", "DDB_G0267646", "Q54TZ2", "DDB_G0281429", "Q54LH0", "DDB_G0286811", "Q75JI3", "DDB_G0276153" ] }, "reaction_10617652": { "compartment": "compartment_12045", "id": "reaction_10617652", "reactome": "R-DDI-6811427", "name": "COPI vesicle uncoating at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617646" ], "products": [ "species_10617644", "species_10616843", "species_10617604", "species_10617648", "species_10611571" ], "modifiers": [], "additional_components": [ "Q54EW9", "DDB_G0291293", "P34143", "DDB_G0271736", "Q552K3", "DDB_G0275969", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "Q558I0", "DDB_G0272905", "P34141", "DDB_G0291233", "P34140", "DDB_G0277867", "species_29438", "Q55FR9", "DDB_G0267982", "Q55FU2", "DDB_G0267950", "Q54YD8", "DDB_G0278285", "Q54CA7", "DDB_G0293086", "Q54HD4", "DDB_G0289523", "Q54HL0", "DDB_G0289371", "Q23924", "DDB_G0284735", "Q55EZ6", "DDB_G0268702", "Q55CR0", "DDB_G0269942", "Q769F7", "DDB_G0278969", "Q54BN0", "DDB_G0293540", "Q769F9", "DDB_G0288053", "Q769F6", "DDB_G0277923", "Q55CJ0", "DDB_G0270040", "Q55CA1", "DDB_G0270150", "Q54YZ1", "DDB_G0277997", "Q55GJ4", "DDB_G0267646", "Q54TZ2", "DDB_G0281429", "Q54LH0", "DDB_G0286811", "Q86JE5", "DDB_G0272124", "Q556J9", "DDB_G0272889", "Q86JE5", "DDB_G0272124", "Q769F7", "DDB_G0278969", "Q54BN0", "DDB_G0293540", "Q769F9", "DDB_G0288053", "Q769F6", "DDB_G0277923", "Q556J9", "DDB_G0272889", "Q55EZ6", "DDB_G0268702", "Q23924", "DDB_G0284735", "Q54HL0", "DDB_G0289371", "Q54CA7", "DDB_G0293086", "Q54HD4", "DDB_G0289523", "Q54YD8", "DDB_G0278285", "Q55FU2", "DDB_G0267950", "Q55FR9", "DDB_G0267982", "Q769F7", "DDB_G0278969", "Q54BN0", "DDB_G0293540", "Q769F9", "DDB_G0288053", "Q769F6", "DDB_G0277923", "Q55CR0", "DDB_G0269942", "Q55GJ4", "DDB_G0267646", "Q54TZ2", "DDB_G0281429", "Q54LH0", "DDB_G0286811", "P34139", "DDB_G0283757", "species_29420" ] }, "reaction_10618658": { "compartment": "compartment_12045", "id": "reaction_10618658", "reactome": "R-DDI-8850041", "name": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10618647" ], "products": [ "species_10618655", "species_29420" ], "modifiers": [ [ "species_10618647", "catalyst" ] ], "additional_components": [ "Q54UJ4", "DDB_G0281043", "Q54DM6", "DDB_G0292124", "Q54GY8", "DDB_G0289827", "species_29420", "Q54UJ4", "DDB_G0281043", "Q54DM6", "DDB_G0292124", "Q54GY8", "DDB_G0289827", "species_29438", "Q54UJ4", "DDB_G0281043", "Q54DM6", "DDB_G0292124", "Q54GY8", "DDB_G0289827", "species_29420" ] }, "reaction_10618649": { "compartment": "compartment_12045", "id": "reaction_10618649", "reactome": "R-DDI-8850040", "name": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618633", "species_10618645" ], "products": [ "species_10618647" ], "modifiers": [], "additional_components": [ "Q54GY8", "DDB_G0289827", "species_29420", "Q54UJ4", "DDB_G0281043", "Q54DM6", "DDB_G0292124", "Q54UJ4", "DDB_G0281043", "Q54DM6", "DDB_G0292124", "Q54GY8", "DDB_G0289827", "species_29420" ] }, "reaction_10618509": { "compartment": "compartment_20699", "id": "reaction_10618509", "reactome": "R-DDI-8849345", "name": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_548819", "species_8848483" ], "products": [ "species_429785", "species_76194" ], "modifiers": [ [ "species_10618506", "catalyst" ] ], "additional_components": [ "DDB_G0288863" ] }, "reaction_10589211": { "compartment": "compartment_70101", "id": "reaction_10589211", "reactome": "R-DDI-350598", "name": "Arginine<=>Agmatine+CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468" ], "products": [ "species_113528", "species_351164" ], "modifiers": [ [ "species_10589208", "catalyst" ] ], "additional_components": [ "DDB_G0281109" ] }, "reaction_10590640": { "compartment": "compartment_17940", "id": "reaction_10590640", "reactome": "R-DDI-392749", "name": "Transport of L1 into endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590638" ], "products": [ "species_10590638" ], "modifiers": [], "additional_components": [ "Q54F41", "DDB_G0291131", "Q54DN5", "DDB_G0291984", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54H39", "DDB_G0289721", "Q54X82", "DDB_G0279141", "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "Q54F41", "DDB_G0291131", "Q54DN5", "DDB_G0291984", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54H39", "DDB_G0289721", "Q54X82", "DDB_G0279141", "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139" ] }, "reaction_10594030": { "compartment": "compartment_876", "id": "reaction_10594030", "reactome": "R-DDI-555065", "name": "Formation of clathrin coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10585860", "species_10594019" ], "products": [ "species_10590638", "species_29372", "species_29420" ], "modifiers": [ [ "species_10594027", "catalyst" ] ], "additional_components": [ "Q54F41", "DDB_G0291131", "Q54DN5", "DDB_G0291984", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54H39", "DDB_G0289721", "Q54X82", "DDB_G0279141", "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "Q54F41", "DDB_G0291131", "Q54DN5", "DDB_G0291984", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54H39", "DDB_G0289721", "Q54X82", "DDB_G0279141", "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139" ] }, "reaction_10611540": { "compartment": "compartment_5460", "id": "reaction_10611540", "reactome": "R-DDI-5693977", "name": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611519", "species_200671" ], "products": [ "species_10611532", "species_5693978", "species_5693984" ], "modifiers": [ [ "species_10611537", "catalyst" ] ], "additional_components": [ "Q54JV8", "DDB_G0287773", "CHEBI:14949", "CHEBI:50746", "Q54JV8", "DDB_G0287773", "DDB_G0292326" ] }, "reaction_10611545": { "compartment": "compartment_5460", "id": "reaction_10611545", "reactome": "R-DDI-5694018", "name": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611532", "species_113526" ], "products": [ "species_10611515", "species_113529", "species_29362" ], "modifiers": [ [ "species_10611542", "catalyst" ] ], "additional_components": [ "CHEBI:50746", "Q54JV8", "DDB_G0287773", "DDB_G0287773", "Q54EW8", "DDB_G0291648", "species_113596" ] }, "reaction_10611530": { "compartment": "compartment_5460", "id": "reaction_10611530", "reactome": "R-DDI-5693967", "name": "PXLP-K754-GLDC dimer decarboxylates Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_10611515" ], "products": [ "species_10611519", "species_29376" ], "modifiers": [ [ "species_10611527", "catalyst" ] ], "additional_components": [ "DDB_G0287773", "Q54JV8", "DDB_G0287773", "CHEBI:14949", "Q54KM7", "DDB_G0287255" ] }, "reaction_10590766": { "compartment": "compartment_70101", "id": "reaction_10590766", "reactome": "R-DDI-418456", "name": "cGMP is degraded by PDEs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30991" ], "products": [ "species_113578" ], "modifiers": [ [ "species_10590763", "catalyst" ] ], "additional_components": [ "B0G0Y8", "DDB_G0268634", "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121" ] }, "reaction_10590749": { "compartment": "compartment_70101", "id": "reaction_10590749", "reactome": "R-DDI-418436", "name": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468", "species_29368", "species_29364" ], "products": [ "species_202124", "species_29366", "species_29968" ], "modifiers": [ [ "species_10590744", "catalyst" ] ], "additional_components": [ "DDB_G0269912" ] }, "reaction_10618498": { "compartment": "compartment_12045", "id": "reaction_10618498", "reactome": "R-DDI-8848585", "name": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200993", "species_30209" ], "products": [ "species_76194", "species_2534407" ], "modifiers": [ [ "species_10611937", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10590501": { "compartment": "compartment_17951", "id": "reaction_10590501", "reactome": "R-DDI-390425", "name": "FAR1 reduces PalmCoA to HXOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200993" ], "products": [ "species_29366", "species_8848577", "species_76194" ], "modifiers": [ [ "species_10590498", "catalyst" ] ], "additional_components": [ "DDB_G0289081" ] }, "reaction_10590503": { "compartment": "compartment_17951", "id": "reaction_10590503", "reactome": "R-DDI-390438", "name": "FAR2 reduces PalmCoA to HXOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200993" ], "products": [ "species_29366", "species_8848577", "species_76194" ], "modifiers": [ [ "species_10590498", "catalyst" ] ], "additional_components": [ "DDB_G0289081" ] }, "reaction_10618495": { "compartment": "compartment_12045", "id": "reaction_10618495", "reactome": "R-DDI-8848582", "name": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848577", "species_200993" ], "products": [ "species_8848499", "species_76194" ], "modifiers": [ [ "species_10611937", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10611935": { "compartment": "compartment_12045", "id": "reaction_10611935", "reactome": "R-DDI-5696424", "name": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192172", "species_5696426" ], "products": [ "species_5696412", "species_162743" ], "modifiers": [ [ "species_10611932", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10588683": { "compartment": "compartment_70101", "id": "reaction_10588683", "reactome": "R-DDI-209828", "name": "Tryptophan is hydroxylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_29500", "species_29368" ], "products": [ "species_71112", "species_209911" ], "modifiers": [ [ "species_10588680", "catalyst" ] ], "additional_components": [ "Q54XS1", "DDB_G0278781", "species_71067" ] }, "reaction_10588667": { "compartment": "compartment_70101", "id": "reaction_10588667", "reactome": "R-DDI-209821", "name": "Methylation of N-acetyl-5-HT to form melatonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_209793" ], "products": [ "species_209934", "species_70106", "species_71285" ], "modifiers": [ [ "species_10588664", "catalyst" ] ], "additional_components": [ "Q86I40", "DDB_G0275013", "Q54B59", "DDB_G0293888", "Q54GZ0", "DDB_G0289823", "Q54S95", "DDB_G0282591", "Q8T638", "DDB_G0289329", "Q54B60", "DDB_G0293886", "Q54FP4", "DDB_G0290719", "Q86HS9", "DDB_G0274941" ] }, "reaction_10606827": { "compartment": "compartment_17938", "id": "reaction_10606827", "reactome": "R-DDI-5672010", "name": "Active MTORC1 phosphorylates ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10606817" ], "products": [ "species_29370", "species_10606824" ], "modifiers": [ [ "species_10606817", "catalyst" ] ], "additional_components": [ "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54J54", "DDB_G0288287", "Q86CS2", "DDB_G0292390", "Q55BY0", "DDB_G0269162", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390" ] }, "reaction_10607979": { "compartment": "compartment_12045", "id": "reaction_10607979", "reactome": "R-DDI-5682385", "name": "The phagophore extends from the PIP3-enriched structure", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606839" ], "products": [ "species_10607970" ], "modifiers": [ [ "species_10607975", "catalyst" ] ], "additional_components": [ "Q54JI9", "DDB_G0288021", "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "Q54JI9", "DDB_G0288021", "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "DDB_G0285323" ] }, "reaction_10626468": { "compartment": "compartment_70101", "id": "reaction_10626468", "reactome": "R-DDI-9641089", "name": "Parkin binds Ub:UBE2N:UBE2V1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596322", "species_10626464" ], "products": [ "species_10626466" ], "modifiers": [], "additional_components": [ "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043" ] }, "reaction_10626478": { "compartment": "compartment_70101", "id": "reaction_10626478", "reactome": "R-DDI-9641096", "name": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626474", "species_10626466" ], "products": [ "species_10626476" ], "modifiers": [], "additional_components": [ "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151" ] }, "reaction_10626510": { "compartment": "compartment_70101", "id": "reaction_10626510", "reactome": "R-DDI-9641127", "name": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626506" ], "products": [ "species_10626492" ], "modifiers": [], "additional_components": [ "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54U44", "DDB_G0280973", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54U44", "DDB_G0280973", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765" ] }, "reaction_10626494": { "compartment": "compartment_70101", "id": "reaction_10626494", "reactome": "R-DDI-9641109", "name": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626492" ], "products": [ "species_10626490", "species_10626480" ], "modifiers": [], "additional_components": [ "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54U44", "DDB_G0280973", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54U44", "DDB_G0280973", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596" ] }, "reaction_10626559": { "compartment": "compartment_18667", "id": "reaction_10626559", "reactome": "R-DDI-9646685", "name": "Aggresome dissociates from dynein and microtubule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626551" ], "products": [ "species_10626557", "species_10589898", "species_10605681" ], "modifiers": [], "additional_components": [ "P54703", "DDB_G0280849", "Q86A88", "DDB_G0274815", "Q54CI8", "DDB_G0292904", "P34036", "DDB_G0276355", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54U44", "DDB_G0280973", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54X15", "DDB_G0279267", "species_29438", "species_29420", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54U44", "DDB_G0280973", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54X15", "DDB_G0279267", "species_29438", "species_29420", "P54703", "DDB_G0280849", "Q86A88", "DDB_G0274815", "Q54CI8", "DDB_G0292904", "P34036", "DDB_G0276355" ] }, "reaction_10626508": { "compartment": "compartment_70101", "id": "reaction_10626508", "reactome": "R-DDI-9641111", "name": "Parkin transfers Ub to misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626476" ], "products": [ "species_10626506" ], "modifiers": [], "additional_components": [ "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54U44", "DDB_G0280973", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765" ] }, "reaction_10626541": { "compartment": "compartment_70101", "id": "reaction_10626541", "reactome": "R-DDI-9646348", "name": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626537", "species_10605681" ], "products": [ "species_10626539" ], "modifiers": [], "additional_components": [ "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54U44", "DDB_G0280973", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54X15", "DDB_G0279267", "P54703", "DDB_G0280849", "Q86A88", "DDB_G0274815", "Q54CI8", "DDB_G0292904", "P34036", "DDB_G0276355", "P54703", "DDB_G0280849", "Q86A88", "DDB_G0274815", "Q54CI8", "DDB_G0292904", "P34036", "DDB_G0276355", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54U44", "DDB_G0280973", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54X15", "DDB_G0279267" ] }, "reaction_10623347": { "compartment": "compartment_70101", "id": "reaction_10623347", "reactome": "R-DDI-8948039", "name": "FUNDC1 is phosphorylated by CK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623342", "species_113592" ], "products": [ "species_29370", "species_10623345" ], "modifiers": [ [ "species_10601344", "catalyst" ] ], "additional_components": [ "DDB_G0277699", "DDB_G0277699", "Q54PF1", "DDB_G0284601", "Q02720", "DDB_G0276885", "Q54LR6", "DDB_G0286481" ] }, "reaction_10623360": { "compartment": "compartment_17906", "id": "reaction_10623360", "reactome": "R-DDI-8948146", "name": "FUNDC1 is phosphorylated by ULK1 at Ser17", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623342", "species_113592" ], "products": [ "species_10623357", "species_29370" ], "modifiers": [ [ "species_10623349", "catalyst" ] ], "additional_components": [ "DDB_G0277699", "DDB_G0277699", "DDB_G0292390" ] }, "reaction_10623351": { "compartment": "compartment_17906", "id": "reaction_10623351", "reactome": "R-DDI-8948136", "name": "ULK1 Translocates to the mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606654" ], "products": [ "species_10623349" ], "modifiers": [], "additional_components": [ "DDB_G0292390", "DDB_G0292390" ] }, "reaction_10624119": { "compartment": "compartment_21994", "id": "reaction_10624119", "reactome": "R-DDI-8959571", "name": "LC3 binds the autophagosome membrane Atg5-Atg12 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604606", "species_10624115" ], "products": [ "species_10624117" ], "modifiers": [], "additional_components": [ "Q86CR6", "DDB_G0282929", "Q54GT9", "DDB_G0289881", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q75K07", "DDB_G0277699", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q75K07", "DDB_G0277699", "Q86CR6", "DDB_G0282929", "Q54GT9", "DDB_G0289881" ] }, "reaction_10624121": { "compartment": "compartment_70101", "id": "reaction_10624121", "reactome": "R-DDI-8959573", "name": "Phosphorylated FUNDC1 links damaged mitochondria to LC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623357", "species_10624113" ], "products": [ "species_10624115" ], "modifiers": [], "additional_components": [ "DDB_G0277699", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q75K07", "DDB_G0277699" ] }, "reaction_10627184": { "compartment": "compartment_17947", "id": "reaction_10627184", "reactome": "R-DDI-9664880", "name": "MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627180", "species_10607651" ], "products": [ "species_10627182" ], "modifiers": [], "additional_components": [ "Q54Q21", "DDB_G0284133", "Q55CE3", "DDB_G0270098", "Q54MD1", "DDB_G0286033", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q54Q21", "DDB_G0284133", "Q55CE3", "DDB_G0270098", "Q54MD1", "DDB_G0286033" ] }, "reaction_10627166": { "compartment": "compartment_17947", "id": "reaction_10627166", "reactome": "R-DDI-9664867", "name": "NBR1 binds MAP1LC3B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627162", "species_10607651" ], "products": [ "species_10627164" ], "modifiers": [], "additional_components": [ "DDB_G0284133", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q54Q21", "DDB_G0284133" ] }, "reaction_10606829": { "compartment": "compartment_70101", "id": "reaction_10606829", "reactome": "R-DDI-5672011", "name": "p-AMPK:AMP binds the ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606668", "species_10589958" ], "products": [ "species_10606670" ], "modifiers": [], "additional_components": [ "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390" ] }, "reaction_10607596": { "compartment": "compartment_70101", "id": "reaction_10607596", "reactome": "R-DDI-5676229", "name": "WIPIs bind PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693050", "species_10607592" ], "products": [ "species_10607594" ], "modifiers": [], "additional_components": [ "Q54NA2", "DDB_G0285375", "Q54NA2", "DDB_G0285375", "species_1806200" ] }, "reaction_10607732": { "compartment": "compartment_70101", "id": "reaction_10607732", "reactome": "R-DDI-5679205", "name": "ULK1 phosphorylates Beclin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607717" ], "products": [ "species_29370", "species_10606839" ], "modifiers": [ [ "species_10607729", "catalyst" ] ], "additional_components": [ "Q54JI9", "DDB_G0288021", "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "Q54JI9", "DDB_G0288021", "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390" ] }, "reaction_10608055": { "compartment": "compartment_70101", "id": "reaction_10608055", "reactome": "R-DDI-5683593", "name": "ATG7:ATG3:LC3 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607764" ], "products": [ "species_10607673", "species_10607749" ], "modifiers": [], "additional_components": [ "Q86CR9", "DDB_G0271096", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q550A8", "DDB_G0277319", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q550A8", "DDB_G0277319", "Q86CR9", "DDB_G0271096" ] }, "reaction_10607737": { "compartment": "compartment_70101", "id": "reaction_10607737", "reactome": "R-DDI-5679206", "name": "MTMR14, MTMR3 dephosphorylate PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676030" ], "products": [ "species_426639" ], "modifiers": [ [ "species_10607734", "catalyst" ] ], "additional_components": [ "Q54H00", "DDB_G0289807", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258" ] }, "reaction_10607739": { "compartment": "compartment_70101", "id": "reaction_10607739", "reactome": "R-DDI-5679239", "name": "ULK complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607573" ], "products": [ "species_10607729" ], "modifiers": [], "additional_components": [ "Q54J54", "DDB_G0288287", "Q86CS2", "DDB_G0292390", "Q55BY0", "DDB_G0269162", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390" ] }, "reaction_10606842": { "compartment": "compartment_12045", "id": "reaction_10606842", "reactome": "R-DDI-5672012", "name": "Beclin-1 complex phosphorylates PtdIns", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426639" ], "products": [ "species_29370", "species_5676030" ], "modifiers": [ [ "species_10606839", "catalyst" ] ], "additional_components": [ "Q54JI9", "DDB_G0288021", "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627" ] }, "reaction_10607741": { "compartment": "compartment_70101", "id": "reaction_10607741", "reactome": "R-DDI-5679255", "name": "WIPI2 binds ATG12:ATG5:ATG16L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607693", "species_10607691" ], "products": [ "species_10607695" ], "modifiers": [], "additional_components": [ "species_1806205", "Q54NA2", "DDB_G0285375", "O15736", "DDB_G0275323", "Q86CR6", "DDB_G0282929", "Q54GT9", "DDB_G0289881", "O15736", "DDB_G0275323", "Q86CR6", "DDB_G0282929", "Q54GT9", "DDB_G0289881", "species_1806205", "Q54NA2", "DDB_G0285375" ] }, "reaction_10606846": { "compartment": "compartment_17938", "id": "reaction_10606846", "reactome": "R-DDI-5672017", "name": "Rheb in the MTORC1 complex hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584242" ], "products": [ "species_10589976" ], "modifiers": [ [ "species_10584242", "catalyst" ] ], "additional_components": [ "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318" ] }, "reaction_10607747": { "compartment": "compartment_70101", "id": "reaction_10607747", "reactome": "R-DDI-5679266", "name": "Beclin-1 complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607745" ], "products": [ "species_10607717" ], "modifiers": [], "additional_components": [ "Q54JI9", "DDB_G0288021", "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "Q54JI9", "DDB_G0288021", "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627" ] }, "reaction_10606850": { "compartment": "compartment_70101", "id": "reaction_10606850", "reactome": "R-DDI-5672817", "name": "Active MTORC1 binds the ULK1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606668", "species_10584242" ], "products": [ "species_10606817" ], "modifiers": [], "additional_components": [ "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390" ] }, "reaction_10607753": { "compartment": "compartment_70101", "id": "reaction_10607753", "reactome": "R-DDI-5681980", "name": "ATG12 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607684", "species_10607749" ], "products": [ "species_10607751" ], "modifiers": [], "additional_components": [ "DDB_G0282929", "Q86CR9", "DDB_G0271096", "Q86CR9", "DDB_G0271096", "Q86CR6", "DDB_G0282929" ] }, "reaction_10607564": { "compartment": "compartment_74700", "id": "reaction_10607564", "reactome": "R-DDI-5675790", "name": "MTORC1 dissociates from ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607256" ], "products": [ "species_10606822", "species_10584309" ], "modifiers": [], "additional_components": [ "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54J54", "DDB_G0288287", "Q86CS2", "DDB_G0292390", "Q55BY0", "DDB_G0269162", "Q54J54", "DDB_G0288287", "Q86CS2", "DDB_G0292390", "Q55BY0", "DDB_G0269162", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318" ] }, "reaction_10625487": { "compartment": "compartment_70101", "id": "reaction_10625487", "reactome": "R-DDI-9020616", "name": "ATG12 forms a thioester bond with ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607751" ], "products": [ "species_10608021" ], "modifiers": [], "additional_components": [ "Q86CR9", "DDB_G0271096", "Q86CR6", "DDB_G0282929", "Q86CR6", "DDB_G0282929", "Q86CR9", "DDB_G0271096" ] }, "reaction_10608017": { "compartment": "compartment_5683628", "id": "reaction_10608017", "reactome": "R-DDI-5682388", "name": "Autophagosome maturation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607675" ], "products": [ "species_10608008" ], "modifiers": [ [ "species_10608015", "catalyst" ], [ "species_10594491", "catalyst" ] ], "additional_components": [ "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "species_1500581", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "species_1500581", "Q54JI9", "DDB_G0288021", "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627", "Q54JC5", "DDB_G0288175", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54P63", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q86H98", "DDB_G0275573" ] }, "reaction_10607824": { "compartment": "compartment_70101", "id": "reaction_10607824", "reactome": "R-DDI-5681987", "name": "LC3 is cleaved by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607793" ], "products": [ "species_10607665" ], "modifiers": [ [ "species_10607821", "catalyst" ] ], "additional_components": [ "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q557H7", "DDB_G0273443" ] }, "reaction_10607826": { "compartment": "compartment_70101", "id": "reaction_10607826", "reactome": "R-DDI-5682011", "name": "LC3 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607749", "species_10607665" ], "products": [ "species_10607760" ], "modifiers": [], "additional_components": [ "Q86CR9", "DDB_G0271096", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096" ] }, "reaction_10607698": { "compartment": "compartment_70101", "id": "reaction_10607698", "reactome": "R-DDI-5678490", "name": "ATG16L1 complex transfers LC3 from ATG3 to PE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5681998", "species_10607673" ], "products": [ "species_10607677", "species_10607675" ], "modifiers": [ [ "species_10607695", "catalyst" ] ], "additional_components": [ "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q550A8", "DDB_G0277319", "DDB_G0277319", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "species_1500581", "O15736", "DDB_G0275323", "Q86CR6", "DDB_G0282929", "Q54GT9", "DDB_G0289881", "species_1806205", "Q54NA2", "DDB_G0285375" ] }, "reaction_10608023": { "compartment": "compartment_70101", "id": "reaction_10608023", "reactome": "R-DDI-5682896", "name": "LC3:ATG7 dimer binds ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607677", "species_10607760" ], "products": [ "species_10607762" ], "modifiers": [], "additional_components": [ "DDB_G0277319", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096", "Q550A8", "DDB_G0277319" ] }, "reaction_10607767": { "compartment": "compartment_70101", "id": "reaction_10607767", "reactome": "R-DDI-5681981", "name": "ATG3 transfers LC3 from ATG7 to ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607762" ], "products": [ "species_10607764" ], "modifiers": [ [ "species_10607762", "catalyst" ] ], "additional_components": [ "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096", "Q550A8", "DDB_G0277319", "Q86CR9", "DDB_G0271096", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q550A8", "DDB_G0277319", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR9", "DDB_G0271096", "Q550A8", "DDB_G0277319" ] }, "reaction_10607576": { "compartment": "compartment_70101", "id": "reaction_10607576", "reactome": "R-DDI-5675868", "name": "ULK1 phosphorylates ATG13 and RB1CC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606812", "species_113592" ], "products": [ "species_29370", "species_10607573" ], "modifiers": [ [ "species_10606812", "catalyst" ] ], "additional_components": [ "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54J54", "DDB_G0288287", "Q86CS2", "DDB_G0292390", "Q55BY0", "DDB_G0269162", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390" ] }, "reaction_10607258": { "compartment": "compartment_70101", "id": "reaction_10607258", "reactome": "R-DDI-5673768", "name": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10606824" ], "products": [ "species_29370", "species_10607256" ], "modifiers": [ [ "species_10589958", "catalyst" ] ], "additional_components": [ "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54J54", "DDB_G0288287", "Q86CS2", "DDB_G0292390", "Q55BY0", "DDB_G0269162", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54J54", "DDB_G0288287", "Q86CS2", "DDB_G0292390", "Q55BY0", "DDB_G0269162", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643" ] }, "reaction_10608090": { "compartment": "compartment_70101", "id": "reaction_10608090", "reactome": "R-DDI-5683925", "name": "ULK1 is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606822" ], "products": [ "species_10606668", "species_29372" ], "modifiers": [], "additional_components": [ "Q54J54", "DDB_G0288287", "Q86CS2", "DDB_G0292390", "Q55BY0", "DDB_G0269162", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390" ] }, "reaction_10606684": { "compartment": "compartment_70101", "id": "reaction_10606684", "reactome": "R-DDI-5665868", "name": "AMPK (complex) phosphorylates ULK1 (complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606670", "species_113592" ], "products": [ "species_29370", "species_10606681" ], "modifiers": [ [ "species_10606670", "catalyst" ] ], "additional_components": [ "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54J54", "DDB_G0288287", "Q86CS2", "DDB_G0292390", "Q55BY0", "DDB_G0269162", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390" ] }, "reaction_10606815": { "compartment": "compartment_70101", "id": "reaction_10606815", "reactome": "R-DDI-5672008", "name": "Thr-180 of ULK1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10606681" ], "products": [ "species_10606812", "species_29370" ], "modifiers": [ [ "species_10606681", "catalyst" ] ], "additional_components": [ "Q54J54", "DDB_G0288287", "Q86CS2", "DDB_G0292390", "Q55BY0", "DDB_G0269162", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "Q54J54", "DDB_G0288287", "Q55BY0", "DDB_G0269162", "Q86CS2", "DDB_G0292390", "Q54J54", "DDB_G0288287", "Q86CS2", "DDB_G0292390", "Q55BY0", "DDB_G0269162", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643" ] }, "reaction_10607966": { "compartment": "compartment_70101", "id": "reaction_10607966", "reactome": "R-DDI-5682377", "name": "LC3 de-lipidation by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607675" ], "products": [ "species_5681998", "species_10607665" ], "modifiers": [ [ "species_10607821", "catalyst" ] ], "additional_components": [ "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "species_1500581", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q557H7", "DDB_G0273443" ] }, "reaction_10611248": { "compartment": "compartment_70101", "id": "reaction_10611248", "reactome": "R-DDI-5691512", "name": "APEH hydrolyses NAc-Ser-protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5691496", "species_29356" ], "products": [ "species_6785226", "species_5691517" ], "modifiers": [ [ "species_10611245", "catalyst" ] ], "additional_components": [ "species_5691517", "species_6785219", "DDB_G0267742" ] }, "reaction_10616060": { "compartment": "compartment_70101", "id": "reaction_10616060", "reactome": "R-DDI-6800138", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616038", "species_71284" ], "products": [ "species_10616045", "species_71285" ], "modifiers": [ [ "species_10616057", "catalyst" ] ], "additional_components": [ "Q7YZN9", "DDB_G0277919", "species_29438", "Q9BMX0", "DDB_G0288613", "Q7YZN9", "DDB_G0277919", "species_29438", "Q9BMX0", "DDB_G0288613", "Q54DT3", "DDB_G0292048", "Q54N57", "DDB_G0285489" ] }, "reaction_10601939": { "compartment": "compartment_13231", "id": "reaction_10601939", "reactome": "R-DDI-3000449", "name": "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10601921" ], "products": [ "species_10601725", "species_10601936" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54N16", "DDB_G0285563", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54N16", "DDB_G0285563", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10626247": { "compartment": "compartment_1598585", "id": "reaction_10626247", "reactome": "R-DDI-9624845", "name": "RCC1 stimulates GDP to GTP exchange on RAN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10587842" ], "products": [ "species_10626239", "species_29420" ], "modifiers": [ [ "species_10626244", "catalyst" ] ], "additional_components": [ "P33519", "DDB_G0291235", "species_29420", "P33519", "DDB_G0291235", "species_29438", "DDB_G0270246" ] }, "reaction_10626251": { "compartment": "compartment_70101", "id": "reaction_10626251", "reactome": "R-DDI-9624876", "name": "RAN:GTP recruits nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9624879", "species_10626239" ], "products": [ "species_10626249" ], "modifiers": [], "additional_components": [ "P33519", "DDB_G0291235", "species_29438", "P33519", "DDB_G0291235", "species_29438" ] }, "reaction_10626254": { "compartment": "compartment_70101", "id": "reaction_10626254", "reactome": "R-DDI-9624893", "name": "RAN stimulates fusion of nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10626249" ], "products": [ "species_29372", "species_9624890", "species_10587842" ], "modifiers": [ [ "species_10601936", "catalyst" ] ], "additional_components": [ "P33519", "DDB_G0291235", "species_29438", "P33519", "DDB_G0291235", "species_29420", "Q54N16", "DDB_G0285563", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10627210": { "compartment": "compartment_13231", "id": "reaction_10627210", "reactome": "R-DDI-9668395", "name": "CHMP7 binds CC2D1B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627194", "species_10627200" ], "products": [ "species_10627202" ], "modifiers": [], "additional_components": [ "DDB_G0283793", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54P63", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54P63", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54QK5", "DDB_G0283793" ] }, "reaction_10627208": { "compartment": "compartment_70101", "id": "reaction_10627208", "reactome": "R-DDI-9668389", "name": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594774", "species_10627204" ], "products": [ "species_10627206" ], "modifiers": [], "additional_components": [ "DDB_G0284347", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54P63", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54QK5", "DDB_G0283793", "Q54KQ7", "DDB_G0287165", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54P63", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54QK5", "DDB_G0283793", "Q54KQ7", "DDB_G0287165", "Q54PT2", "DDB_G0284347" ] }, "reaction_10627215": { "compartment": "compartment_70101", "id": "reaction_10627215", "reactome": "R-DDI-9668419", "name": "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10589898", "species_113592" ], "products": [ "species_29372", "species_29370", "species_10589894" ], "modifiers": [ [ "species_10627204", "catalyst" ] ], "additional_components": [ "species_29438", "species_29420", "species_29438", "species_29420", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54P63", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54QK5", "DDB_G0283793", "Q54KQ7", "DDB_G0287165" ] }, "reaction_10627212": { "compartment": "compartment_70101", "id": "reaction_10627212", "reactome": "R-DDI-9668405", "name": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627189", "species_10627202" ], "products": [ "species_10627204" ], "modifiers": [], "additional_components": [ "DDB_G0287165", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54P63", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54QK5", "DDB_G0283793", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54P63", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q86H98", "DDB_G0275573", "Q54I39", "DDB_G0289029", "Q54QK5", "DDB_G0283793", "Q54KQ7", "DDB_G0287165" ] }, "reaction_10606306": { "compartment": "compartment_70101", "id": "reaction_10606306", "reactome": "R-DDI-5652172", "name": "AKR1B1 reduces Glc to D-sorbitol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_70113" ], "products": [ "species_29366", "species_5652213" ], "modifiers": [ [ "species_10586772", "catalyst" ] ], "additional_components": [ "Q55FL3", "DDB_G0268058", "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562" ] }, "reaction_10577683": { "compartment": "compartment_70101", "id": "reaction_10577683", "reactome": "R-DDI-70333", "name": "KHK dimer phosphorylates Fru to Fru 1-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29532", "species_113592" ], "products": [ "species_29370", "species_31221" ], "modifiers": [ [ "species_10577680", "catalyst" ], [ "species_29804", "catalyst" ], [ "species_29370", "inhibitor" ] ], "additional_components": [ "Q54D80", "DDB_G0292440" ] }, "reaction_10577703": { "compartment": "compartment_70101", "id": "reaction_10577703", "reactome": "R-DDI-70349", "name": "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30393", "species_113592" ], "products": [ "species_29578", "species_29370" ], "modifiers": [ [ "species_10577700", "catalyst" ] ], "additional_components": [ "Q55EE0", "DDB_G0269274", "species_29926" ] }, "reaction_10577693": { "compartment": "compartment_70101", "id": "reaction_10577693", "reactome": "R-DDI-70342", "name": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31221" ], "products": [ "species_30393", "species_75970" ], "modifiers": [ [ "species_10577690", "catalyst" ] ], "additional_components": [ "Q86A67", "DDB_G0274375" ] }, "reaction_10617821": { "compartment": "compartment_70101", "id": "reaction_10617821", "reactome": "R-DDI-6813749", "name": "ALDH1A1 oxidises GA to DGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30393", "species_29360" ], "products": [ "species_6799497", "species_70106", "species_73473" ], "modifiers": [ [ "species_10578688", "catalyst" ] ], "additional_components": [ "Q54IU0", "DDB_G0288521" ] }, "reaction_10605267": { "compartment": "compartment_7660", "id": "reaction_10605267", "reactome": "R-DDI-5358510", "name": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605263", "species_10577431", "species_10605249" ], "products": [ "species_10605265" ], "modifiers": [], "additional_components": [ "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_113592", "Q54K47", "DDB_G0287607", "Q54KD8", "DDB_G0287393", "Q54QA0", "DDB_G0283981", "Q54KD8", "DDB_G0287393", "Q54QA0", "DDB_G0283981", "Q54K47", "DDB_G0287607", "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_113592" ] }, "reaction_10605283": { "compartment": "compartment_7660", "id": "reaction_10605283", "reactome": "R-DDI-5358518", "name": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605265" ], "products": [ "species_10605280" ], "modifiers": [ [ "species_10605265", "catalyst" ] ], "additional_components": [ "Q54KD8", "DDB_G0287393", "Q54QA0", "DDB_G0283981", "Q54K47", "DDB_G0287607", "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_113592", "Q54KD8", "DDB_G0287393", "Q54QA0", "DDB_G0283981", "Q54K47", "DDB_G0287607", "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_113592", "Q54KD8", "DDB_G0287393", "Q54QA0", "DDB_G0283981", "Q54K47", "DDB_G0287607", "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_113592" ] }, "reaction_10605300": { "compartment": "compartment_7660", "id": "reaction_10605300", "reactome": "R-DDI-5358597", "name": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605296", "species_10605280" ], "products": [ "species_10605298" ], "modifiers": [], "additional_components": [ "DDB_G0291570", "Q54KD8", "DDB_G0287393", "Q54QA0", "DDB_G0283981", "Q54K47", "DDB_G0287607", "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_113592", "Q54KD8", "DDB_G0287393", "Q54QA0", "DDB_G0283981", "Q54ED2", "DDB_G0291570", "Q54K47", "DDB_G0287607", "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_113592" ] }, "reaction_10605302": { "compartment": "compartment_7660", "id": "reaction_10605302", "reactome": "R-DDI-5358912", "name": "MSH2:MSH6 exchanges ADP for ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10605287" ], "products": [ "species_113582", "species_10605263" ], "modifiers": [], "additional_components": [ "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_29370", "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_113592" ] }, "reaction_10605289": { "compartment": "compartment_7660", "id": "reaction_10605289", "reactome": "R-DDI-5358525", "name": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605285", "species_5358514" ], "products": [ "species_10605287" ], "modifiers": [], "additional_components": [ "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_29370", "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_29370" ] }, "reaction_10605291": { "compartment": "compartment_7660", "id": "reaction_10605291", "reactome": "R-DDI-5358592", "name": "DNA ligase I ligates single stranded nick in double stranded DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_5358610" ], "products": [ "species_109966", "species_164121", "species_113541" ], "modifiers": [ [ "species_10577488", "catalyst" ] ], "additional_components": [ "DDB_G0274493" ] }, "reaction_10605389": { "compartment": "compartment_7660", "id": "reaction_10605389", "reactome": "R-DDI-5444516", "name": "Formation of MSH2:MSH6 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113582", "species_10605259", "species_10605254" ], "products": [ "species_10605285" ], "modifiers": [], "additional_components": [ "DDB_G0268614", "DDB_G0275809", "Q553L4", "DDB_G0275809", "Q55GU9", "DDB_G0268614", "species_29370" ] }, "reaction_10605391": { "compartment": "compartment_7660", "id": "reaction_10605391", "reactome": "R-DDI-5444523", "name": "Formation of MSH1:PMS2 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605247", "species_10605242" ], "products": [ "species_10605249" ], "modifiers": [], "additional_components": [ "DDB_G0283981", "DDB_G0287393", "Q54KD8", "DDB_G0287393", "Q54QA0", "DDB_G0283981" ] }, "reaction_10605387": { "compartment": "compartment_7660", "id": "reaction_10605387", "reactome": "R-DDI-5444511", "name": "Formation of MSH2:MSH3 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113582", "species_10605272", "species_10605254" ], "products": [ "species_10605274" ], "modifiers": [], "additional_components": [ "DDB_G0281683", "DDB_G0275809", "Q553L4", "DDB_G0275809", "Q1ZXH0", "DDB_G0281683", "species_29370" ] }, "reaction_10605278": { "compartment": "compartment_7660", "id": "reaction_10605278", "reactome": "R-DDI-5358513", "name": "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5358527", "species_10605274" ], "products": [ "species_10605276" ], "modifiers": [], "additional_components": [ "Q553L4", "DDB_G0275809", "Q1ZXH0", "DDB_G0281683", "species_29370", "Q553L4", "DDB_G0275809", "Q1ZXH0", "DDB_G0281683", "species_29370" ] }, "reaction_10582371": { "compartment": "compartment_7660", "id": "reaction_10582371", "reactome": "R-DDI-77071", "name": "Phosphorylation (Ser5) of RNA pol II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10582368" ], "products": [ "species_113582", "species_10582364" ], "modifiers": [ [ "species_10582368", "catalyst" ] ], "additional_components": [ "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729" ] }, "reaction_10582386": { "compartment": "compartment_7660", "id": "reaction_10582386", "reactome": "R-DDI-77073", "name": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582382", "species_10582376", "species_10582360" ], "products": [ "species_10582384" ], "modifiers": [], "additional_components": [ "DDB_G0287661", "DDB_G0278479", "Q54HV6", "DDB_G0289199", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661" ] }, "reaction_10582362": { "compartment": "compartment_7660", "id": "reaction_10582362", "reactome": "R-DDI-77068", "name": "Activation of GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582360" ], "products": [ "species_10582360" ], "modifiers": [], "additional_components": [ "Q54HV6", "DDB_G0289199", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10583326": { "compartment": "compartment_7660", "id": "reaction_10583326", "reactome": "R-DDI-113430", "name": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582368" ], "products": [ "species_10582368" ], "modifiers": [], "additional_components": [ "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729" ] }, "reaction_10582366": { "compartment": "compartment_7660", "id": "reaction_10582366", "reactome": "R-DDI-77069", "name": "RNA Polymerase II CTD (phosphorylated) binds to CE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582364", "species_10582358" ], "products": [ "species_10582360" ], "modifiers": [], "additional_components": [ "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "DDB_G0289199", "Q54HV6", "DDB_G0289199", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10577491": { "compartment": "compartment_7660", "id": "reaction_10577491", "reactome": "R-DDI-69173", "name": "Joining of adjacent Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_68452" ], "products": [ "species_69172" ], "modifiers": [ [ "species_10577488", "catalyst" ] ], "additional_components": [ "DDB_G0274493" ] }, "reaction_10577467": { "compartment": "compartment_7660", "id": "reaction_10577467", "reactome": "R-DDI-69116", "name": "Formation of Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577460" ], "products": [ "species_10577464" ], "modifiers": [ [ "species_10577458", "catalyst" ] ], "additional_components": [ "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609" ] }, "reaction_10577483": { "compartment": "compartment_7660", "id": "reaction_10577483", "reactome": "R-DDI-69152", "name": "Removal of remaining Flap", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577473" ], "products": [ "species_10577475" ], "modifiers": [ [ "species_10577480", "catalyst" ] ], "additional_components": [ "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "DDB_G0284987" ] }, "reaction_10577471": { "compartment": "compartment_7660", "id": "reaction_10577471", "reactome": "R-DDI-69127", "name": "Formation of the Flap Intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577464" ], "products": [ "species_10577469" ], "modifiers": [], "additional_components": [ "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731" ] }, "reaction_10595408": { "compartment": "compartment_20699", "id": "reaction_10595408", "reactome": "R-DDI-964825", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964831" ], "products": [ "species_964752", "species_964740" ], "modifiers": [ [ "species_10595395", "catalyst" ] ], "additional_components": [ "CHEBI:60629", "CHEBI:60628", "CHEBI:60627", "Q54CH4", "DDB_G0292918", "Q54PP9", "DDB_G0292918", "Q54PQ0", "DDB_G0292918", "Q54PQ1", "DDB_G0292918", "Q55EU0", "DDB_G0292918" ] }, "reaction_10595410": { "compartment": "compartment_20699", "id": "reaction_10595410", "reactome": "R-DDI-964830", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964828" ], "products": [ "species_964752", "species_964740" ], "modifiers": [ [ "species_10595395", "catalyst" ] ], "additional_components": [ "Q54CH4", "DDB_G0292918", "Q54PP9", "DDB_G0292918", "Q54PQ0", "DDB_G0292918", "Q54PQ1", "DDB_G0292918", "Q55EU0", "DDB_G0292918" ] }, "reaction_10595398": { "compartment": "compartment_20699", "id": "reaction_10595398", "reactome": "R-DDI-964737", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_915149" ], "products": [ "species_964752", "species_964740" ], "modifiers": [ [ "species_10595395", "catalyst" ] ], "additional_components": [ "Q54CH4", "DDB_G0292918", "Q54PP9", "DDB_G0292918", "Q54PQ0", "DDB_G0292918", "Q54PQ1", "DDB_G0292918", "Q55EU0", "DDB_G0292918" ] }, "reaction_10595406": { "compartment": "compartment_20699", "id": "reaction_10595406", "reactome": "R-DDI-964768", "name": "Addition of GlcNAc to the glycan on the A arm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_964740" ], "products": [ "species_964837", "species_205687" ], "modifiers": [ [ "species_10595403", "catalyst" ] ], "additional_components": [ "DDB_G0288463" ] }, "reaction_10593280": { "compartment": "compartment_70101", "id": "reaction_10593280", "reactome": "R-DDI-450466", "name": "AUF1:mRNA complex is destroyed", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593278" ], "products": [], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q86I71", "DDB_G0279695", "Q54WE9", "DDB_G0279695", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10593258": { "compartment": "compartment_70101", "id": "reaction_10593258", "reactome": "R-DDI-450434", "name": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_450444", "species_10593252" ], "products": [ "species_10593256" ], "modifiers": [], "additional_components": [ "Q54WE9", "DDB_G0279695", "Q86I71", "DDB_G0279695", "Q54WE9", "DDB_G0279695", "Q86I71", "DDB_G0279695" ] }, "reaction_10591793": { "compartment": "compartment_114584", "id": "reaction_10591793", "reactome": "R-DDI-429157", "name": "ABCC4 accumulation of dense granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370" ], "products": [ "species_114565" ], "modifiers": [ [ "species_10591790", "catalyst" ] ], "additional_components": [ "DDB_G0284867" ] }, "reaction_10589393": { "compartment": "compartment_161320", "id": "reaction_10589393", "reactome": "R-DDI-351341", "name": "Exocytosis of Proactivator polypeptide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589385" ], "products": [ "species_10589391" ], "modifiers": [], "additional_components": [ "Q54WE0", "DDB_G0279713", "Q54G42", "DDB_G0290417", "Q54G42", "DDB_G0290417", "Q54WE0", "DDB_G0279713" ] }, "reaction_10593603": { "compartment": "compartment_876", "id": "reaction_10593603", "reactome": "R-DDI-481010", "name": "Surface deployment of platelet dense granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593573" ], "products": [ "species_10593601" ], "modifiers": [], "additional_components": [ "Q54P07", "DDB_G0285051", "Q8T193", "DDB_G0294577", "Q54S62", "DDB_G0294577", "Q1ZXG2", "DDB_G0294577", "Q54S63", "DDB_G0282651", "Q1ZXN9", "DDB_G0294577", "Q55EF0", "DDB_G0269262", "Q54E92", "DDB_G0291738", "Q55EG6", "DDB_G0268910", "Q54FL2", "DDB_G0290783", "Q86JC8", "DDB_G0275955", "Q54G48", "DDB_G0290407", "Q86JP5", "DDB_G0271980", "Q1ZXG2", "DDB_G0294577", "Q1ZXN9", "DDB_G0294577", "Q54E92", "DDB_G0291738", "Q54FL2", "DDB_G0290783", "Q54G48", "DDB_G0290407", "Q54P07", "DDB_G0285051", "Q54S62", "DDB_G0294577", "Q54S63", "DDB_G0282651", "Q55EF0", "DDB_G0269262", "Q55EG6", "DDB_G0268910", "Q86JC8", "DDB_G0275955", "Q86JP5", "DDB_G0271980", "Q8T193", "DDB_G0294577" ] }, "reaction_10593475": { "compartment": "compartment_876", "id": "reaction_10593475", "reactome": "R-DDI-481007", "name": "Exocytosis of platelet alpha granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593433" ], "products": [ "species_10593473" ], "modifiers": [], "additional_components": [ "Q55ET7", "DDB_G0268758", "Q55DM8", "DDB_G0269600", "Q55FE2", "DDB_G0268156", "Q86A67", "DDB_G0274375", "Q553C3", "DDB_G0275765", "Q54KR6", "DDB_G0287201", "Q8T2H0", "DDB_G0272190", "P05095", "DDB_G0268632", "Q54V78", "DDB_G0280565", "Q54PA3", "DDB_G0284679", "Q54D77", "DDB_G0292538", "Q86A67", "DDB_G0274375", "Q54KR6", "DDB_G0287201", "Q54D77", "DDB_G0292538", "Q55ET7", "DDB_G0268758", "Q8T2H0", "DDB_G0272190", "Q54PA3", "DDB_G0284679", "P05095", "DDB_G0268632", "Q54V78", "DDB_G0280565", "Q55FE2", "DDB_G0268156", "Q55DM8", "DDB_G0269600", "Q553C3", "DDB_G0275765" ] }, "reaction_10593506": { "compartment": "compartment_876", "id": "reaction_10593506", "reactome": "R-DDI-481009", "name": "Exocytosis of platelet dense granule content", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593494" ], "products": [ "species_10593504" ], "modifiers": [], "additional_components": [ "species_29438", "species_29372", "species_29370", "Q54F16", "DDB_G0291191", "P04988", "DDB_G0290957", "species_29926", "species_74112", "Q54D84", "DDB_G0292436", "species_113592", "species_209914", "species_29420", "species_113541", "species_74112", "species_29438", "species_29370", "species_113541", "species_29926", "species_209914", "species_113592", "species_29372", "P04988", "DDB_G0290957", "Q54F16", "DDB_G0291191", "species_29420", "Q54D84", "DDB_G0292436" ] }, "reaction_10593830": { "compartment": "compartment_70101", "id": "reaction_10593830", "reactome": "R-DDI-482772", "name": "Release of platelet cytosolic components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593734" ], "products": [ "species_10593828" ], "modifiers": [], "additional_components": [ "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "Q54TA6", "DDB_G0281889", "P32255", "DDB_G0287689", "Q55GQ5", "DDB_G0267420", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993", "Q54RX2", "DDB_G0282859", "Q54W22", "DDB_G0282287", "Q551W8", "DDB_G0282287", "Q54ST8", "DDB_G0282287", "Q54QM3", "DDB_G0283859", "Q54QC8", "DDB_G0283937", "Q54ZW8", "DDB_G0277343", "Q556T3", "DDB_G0273107", "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54L54", "DDB_G0286893", "Q54JD4", "DDB_G0288133", "P54686", "DDB_G0278733", "Q54K81", "DDB_G0287505", "P24639", "DDB_G0269160", "Q54PW0", "DDB_G0284261", "P54686", "DDB_G0278733", "P24639", "DDB_G0269160", "Q54PW0", "DDB_G0284261", "Q54RX2", "DDB_G0282859", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993", "Q55GQ5", "DDB_G0267420", "Q54QM3", "DDB_G0283859", "P32255", "DDB_G0287689", "Q54TA6", "DDB_G0281889", "Q54L54", "DDB_G0286893", "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54JD4", "DDB_G0288133", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "O00897", "DDB_G0269104", "Q54K81", "DDB_G0287505", "Q54QC8", "DDB_G0283937", "Q54ZW8", "DDB_G0277343", "Q54ST8", "DDB_G0282287", "Q54W22", "DDB_G0282287", "Q551W8", "DDB_G0282287", "Q556T3", "DDB_G0273107" ] }, "reaction_10593644": { "compartment": "compartment_876", "id": "reaction_10593644", "reactome": "R-DDI-481044", "name": "Surface deployment of platelet alpha granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593628" ], "products": [ "species_10593642" ], "modifiers": [], "additional_components": [ "Q55CV7", "DDB_G0270986", "Q55CW7", "DDB_G0269872", "Q55CV4", "DDB_G0270682", "Q55CV5", "DDB_G0269110", "Q55FQ9", "DDB_G0267440", "Q9BKJ9", "DDB_G0287035", "Q9XYS8", "DDB_G0267406", "Q54RR0", "DDB_G0282977", "Q9XYS8", "DDB_G0267406", "Q55FQ9", "DDB_G0267440", "Q9BKJ9", "DDB_G0287035", "Q55CV5", "DDB_G0269110", "Q55CV7", "DDB_G0270986", "Q55CW7", "DDB_G0269872", "Q55CV4", "DDB_G0270682", "Q54RR0", "DDB_G0282977" ] }, "reaction_10622966": { "compartment": "compartment_70101", "id": "reaction_10622966", "reactome": "R-DDI-8936849", "name": "AHR:2xHSP90:AIP:PTGES3 binds TCDD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8936852", "species_10622962" ], "products": [ "species_10622964" ], "modifiers": [], "additional_components": [ "Q54R57", "DDB_G0283399", "Q55FM3", "DDB_G0268042", "P54651", "DDB_G0267400", "Q54FE2", "DDB_G0290947", "Q54R57", "DDB_G0283399", "Q55FM3", "DDB_G0268042", "P54651", "DDB_G0267400", "Q54FE2", "DDB_G0290947", "species_8936852" ] }, "reaction_10622996": { "compartment": "compartment_70101", "id": "reaction_10622996", "reactome": "R-DDI-8937169", "name": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622964" ], "products": [ "species_10622994" ], "modifiers": [], "additional_components": [ "Q54R57", "DDB_G0283399", "Q55FM3", "DDB_G0268042", "P54651", "DDB_G0267400", "Q54FE2", "DDB_G0290947", "species_8936852", "P54651", "DDB_G0267400", "Q54R57", "DDB_G0283399", "Q54FE2", "DDB_G0290947", "Q55FM3", "DDB_G0268042", "species_8936852" ] }, "reaction_10623002": { "compartment": "compartment_7660", "id": "reaction_10623002", "reactome": "R-DDI-8937191", "name": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622994" ], "products": [ "species_10623000", "species_10622998" ], "modifiers": [], "additional_components": [ "P54651", "DDB_G0267400", "Q54R57", "DDB_G0283399", "Q54FE2", "DDB_G0290947", "Q55FM3", "DDB_G0268042", "species_8936852", "P54651", "DDB_G0267400", "Q54R57", "DDB_G0283399", "Q55FM3", "DDB_G0268042", "species_8936852", "Q54FE2", "DDB_G0290947" ] }, "reaction_10616539": { "compartment": "compartment_7660", "id": "reaction_10616539", "reactome": "R-DDI-6803523", "name": "PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10579116", "species_10579164", "species_10616535" ], "products": [ "species_10616537" ], "modifiers": [], "additional_components": [ "DDB_G0280393", "DDB_G0284321", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54PW8", "DDB_G0284321", "Q54VI2", "DDB_G0280393" ] }, "reaction_10582577": { "compartment": "compartment_876", "id": "reaction_10582577", "reactome": "R-DDI-109700", "name": "AKT2 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10582573" ], "products": [ "species_10582559", "species_10582575" ], "modifiers": [], "additional_components": [ "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "Q556W3", "DDB_G0273293", "DDB_G0273293", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_179838" ] }, "reaction_10582601": { "compartment": "compartment_70101", "id": "reaction_10582601", "reactome": "R-DDI-109702", "name": "PDPK1 phosphorylates AKT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582575", "species_113592" ], "products": [ "species_29370", "species_10582598" ], "modifiers": [ [ "species_10582584", "catalyst" ] ], "additional_components": [ "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_179838", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_179838", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10582586": { "compartment": "compartment_876", "id": "reaction_10582586", "reactome": "R-DDI-109701", "name": "PDPK1 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10582582" ], "products": [ "species_10582584" ], "modifiers": [], "additional_components": [ "DDB_G0281471", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10583853": { "compartment": "compartment_70101", "id": "reaction_10583853", "reactome": "R-DDI-162425", "name": "p-S295-PDE3B hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10583850", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121" ] }, "reaction_10605020": { "compartment": "compartment_171062", "id": "reaction_10605020", "reactome": "R-DDI-5252133", "name": "ATP6AP1 binds V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581337", "species_10581332" ], "products": [ "species_10581339" ], "modifiers": [], "additional_components": [ "DDB_G0273483", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q55AH5", "DDB_G0271882", "Q86A77", "DDB_G0274331", "O00780", "DDB_G0275701", "Q54Z13", "DDB_G0277971", "Q76NU1", "DDB_G0277401", "P54648", "DDB_G0284473", "P54641", "DDB_G0273071", "Q86AS7", "DDB_G0274141", "Q54E04", "DDB_G0291858", "P54642", "DDB_G0274381", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q55AH5", "DDB_G0271882", "Q86A77", "DDB_G0274331", "O00780", "DDB_G0275701", "Q54Z13", "DDB_G0277971", "Q76NU1", "DDB_G0277401", "P54648", "DDB_G0284473", "P54641", "DDB_G0273071", "Q86AS7", "DDB_G0274141", "Q54E04", "DDB_G0291858", "P54642", "DDB_G0274381", "Q557I5", "DDB_G0273483" ] }, "reaction_10581342": { "compartment": "compartment_17940", "id": "reaction_10581342", "reactome": "R-DDI-74723", "name": "Endosome acidification", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106" ], "products": [ "species_74722" ], "modifiers": [ [ "species_10581339", "catalyst" ] ], "additional_components": [ "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q55AH5", "DDB_G0271882", "Q86A77", "DDB_G0274331", "O00780", "DDB_G0275701", "Q54Z13", "DDB_G0277971", "Q76NU1", "DDB_G0277401", "P54648", "DDB_G0284473", "P54641", "DDB_G0273071", "Q86AS7", "DDB_G0274141", "Q54E04", "DDB_G0291858", "P54642", "DDB_G0274381", "Q557I5", "DDB_G0273483" ] }, "reaction_10586962": { "compartment": "compartment_70101", "id": "reaction_10586962", "reactome": "R-DDI-198270", "name": "PDPK1 phosphorylates AKT at T308", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10586941", "species_113592" ], "products": [ "species_10586959", "species_29370", "species_10582584" ], "modifiers": [ [ "species_10586941", "catalyst" ] ], "additional_components": [ "Q54TW2", "DDB_G0281471", "species_179838", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "Q54TW2", "DDB_G0281471", "species_179838", "Q54TW2", "DDB_G0281471", "species_179838", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795" ] }, "reaction_10587030": { "compartment": "compartment_70101", "id": "reaction_10587030", "reactome": "R-DDI-198640", "name": "TORC2 (mTOR) phosphorylates AKT at S473", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10587009" ], "products": [ "species_10586939", "species_29370" ], "modifiers": [ [ "species_10587023", "catalyst" ], [ "species_10587028", "inhibitor" ] ], "additional_components": [ "species_179838", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_179838", "Q54D08", "DDB_G0292592", "O77203", "DDB_G0277399", "Q9Y0C9", "DDB_G0284611", "Q86C65", "DDB_G0281569", "species_179838", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "Q556W3", "DDB_G0273293" ] }, "reaction_10600856": { "compartment": "compartment_70101", "id": "reaction_10600856", "reactome": "R-DDI-2316429", "name": "PIP3 recruits PDPK1 to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10587607" ], "products": [ "species_10582584" ], "modifiers": [], "additional_components": [ "DDB_G0281471", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10600858": { "compartment": "compartment_876", "id": "reaction_10600858", "reactome": "R-DDI-2317314", "name": "AKT binds PDPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10586939", "species_10582584" ], "products": [ "species_10586941" ], "modifiers": [], "additional_components": [ "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_179838", "Q54TW2", "DDB_G0281471", "species_179838", "Q54TW2", "DDB_G0281471", "species_179838", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795" ] }, "reaction_10604751": { "compartment": "compartment_70101", "id": "reaction_10604751", "reactome": "R-DDI-5218845", "name": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604748", "species_113592" ], "products": [ "species_5218688", "species_29370", "species_10585144", "species_10585895" ], "modifiers": [ [ "species_10604744", "catalyst" ] ], "additional_components": [ "Q54Q13", "DDB_G0284177", "species_428662", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "DDB_G0284177", "DDB_G0284545" ] }, "reaction_10597490": { "compartment": "compartment_70101", "id": "reaction_10597490", "reactome": "R-DDI-1358789", "name": "Self-ubiquitination of RNF41", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10596295" ], "products": [ "species_10597487" ], "modifiers": [ [ "species_10596295", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q559W7", "DDB_G0283193", "Q55CL1", "DDB_G0283193", "Q54RD2", "DDB_G0283193", "Q559W7", "DDB_G0283193", "Q55CL1", "DDB_G0283193", "Q54RD2", "DDB_G0283193", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q559W7", "DDB_G0283193", "Q55CL1", "DDB_G0283193", "Q54RD2", "DDB_G0283193" ] }, "reaction_10599553": { "compartment": "compartment_70101", "id": "reaction_10599553", "reactome": "R-DDI-1855223", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994141" ], "products": [ "species_29370", "species_1629755" ], "modifiers": [ [ "species_10599359", "catalyst" ] ], "additional_components": [ "Q54B75", "DDB_G0293860", "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0293860", "Q55AP4", "DDB_G0293860" ] }, "reaction_10599443": { "compartment": "compartment_70101", "id": "reaction_10599443", "reactome": "R-DDI-1855193", "name": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629736" ], "products": [ "species_29370", "species_1629738" ], "modifiers": [ [ "species_10599359", "catalyst" ] ], "additional_components": [ "Q54B75", "DDB_G0293860", "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0293860", "Q55AP4", "DDB_G0293860" ] }, "reaction_10599522": { "compartment": "compartment_70101", "id": "reaction_10599522", "reactome": "R-DDI-1855219", "name": "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994141" ], "products": [ "species_29372", "species_994149" ], "modifiers": [ [ "species_10599364", "catalyst" ] ], "additional_components": [ "species_29926", "Q55D87", "DDB_G0269746" ] }, "reaction_10599362": { "compartment": "compartment_70101", "id": "reaction_10599362", "reactome": "R-DDI-1855158", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_113592" ], "products": [ "species_29370", "species_1629759" ], "modifiers": [ [ "species_10599359", "catalyst" ] ], "additional_components": [ "Q54B75", "DDB_G0293860", "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0293860", "Q55AP4", "DDB_G0293860" ] }, "reaction_10599446": { "compartment": "compartment_70101", "id": "reaction_10599446", "reactome": "R-DDI-1855194", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629740" ], "products": [ "species_1629732", "species_29370" ], "modifiers": [ [ "species_10599359", "catalyst" ] ], "additional_components": [ "Q54B75", "DDB_G0293860", "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0293860", "Q55AP4", "DDB_G0293860" ] }, "reaction_10599432": { "compartment": "compartment_70101", "id": "reaction_10599432", "reactome": "R-DDI-1855179", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994141" ], "products": [ "species_29370", "species_1629770" ], "modifiers": [ [ "species_10599429", "catalyst" ] ], "additional_components": [ "DDB_G0288351" ] }, "reaction_10599370": { "compartment": "compartment_70101", "id": "reaction_10599370", "reactome": "R-DDI-1855162", "name": "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994149", "species_113592" ], "products": [ "species_29370", "species_994141" ], "modifiers": [ [ "species_10599364", "catalyst" ] ], "additional_components": [ "species_29926", "Q55D87", "DDB_G0269746" ] }, "reaction_10599562": { "compartment": "compartment_70101", "id": "reaction_10599562", "reactome": "R-DDI-1855227", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629770" ], "products": [ "species_1629765", "species_29370" ], "modifiers": [ [ "species_10599359", "catalyst" ] ], "additional_components": [ "Q54B75", "DDB_G0293860", "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0293860", "Q55AP4", "DDB_G0293860" ] }, "reaction_10597363": { "compartment": "compartment_876", "id": "reaction_10597363", "reactome": "R-DDI-1296039", "name": "Activation of Ca2+ activated Potassium channels with small conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10597360", "catalyst" ] ], "additional_components": [ "Q55CX3", "DDB_G0269864" ] }, "reaction_10597350": { "compartment": "compartment_876", "id": "reaction_10597350", "reactome": "R-DDI-1296035", "name": "Activation of Ca2+ activated Potassium channels with Intermediate conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10597347", "catalyst" ] ], "additional_components": [ "DDB_G0269864" ] }, "reaction_10597483": { "compartment": "compartment_876", "id": "reaction_10597483", "reactome": "R-DDI-1299359", "name": "Activation of TALK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10597480", "catalyst" ] ], "additional_components": [ "Q86K40", "DDB_G0277255", "Q8T268", "DDB_G0277255" ] }, "reaction_10597466": { "compartment": "compartment_876", "id": "reaction_10597466", "reactome": "R-DDI-1299338", "name": "Activation of TRESK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10597463", "catalyst" ] ], "additional_components": [ "Q86K40", "DDB_G0277255", "Q8T268", "DDB_G0277255" ] }, "reaction_10597405": { "compartment": "compartment_876", "id": "reaction_10597405", "reactome": "R-DDI-1299297", "name": "Activation of THIK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10597402", "catalyst" ] ], "additional_components": [ "Q86K40", "DDB_G0277255", "Q8T268", "DDB_G0277255" ] }, "reaction_10597455": { "compartment": "compartment_876", "id": "reaction_10597455", "reactome": "R-DDI-1299318", "name": "Activation of TASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10597452", "catalyst" ] ], "additional_components": [ "Q86K40", "DDB_G0277255", "Q8T268", "DDB_G0277255" ] }, "reaction_10597434": { "compartment": "compartment_876", "id": "reaction_10597434", "reactome": "R-DDI-1299304", "name": "Activation of tandem pore domain in a weak inwardly rectifying K+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10597431", "catalyst" ] ], "additional_components": [ "Q8T268", "DDB_G0277255", "Q86K40", "DDB_G0277255" ] }, "reaction_10590872": { "compartment": "compartment_876", "id": "reaction_10590872", "reactome": "R-DDI-420688", "name": "GABAB heterodimeric receptor binds GABA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589803", "species_352003" ], "products": [ "species_10589805" ], "modifiers": [], "additional_components": [ "Q54F54", "DDB_G0291095", "Q54K09", "DDB_G0287905", "Q54ET0", "DDB_G0291356", "species_916850", "Q54F54", "DDB_G0291095", "Q54K09", "DDB_G0287905", "Q54ET0", "DDB_G0291356" ] }, "reaction_10584963": { "compartment": "compartment_876", "id": "reaction_10584963", "reactome": "R-DDI-170686", "name": "Adenylate cyclase increases the GTPase activity of Gi alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584931" ], "products": [ "species_29372", "species_10584949" ], "modifiers": [ [ "species_10584931", "catalyst" ] ], "additional_components": [ "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545", "species_29420", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29926", "Q03100", "DDB_G0281545", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545" ] }, "reaction_10584951": { "compartment": "compartment_876", "id": "reaction_10584951", "reactome": "R-DDI-170674", "name": "Dissociation of the Gi alpha:G olf complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584949" ], "products": [ "species_10583022", "species_10584933", "species_10584947" ], "modifiers": [], "additional_components": [ "species_29420", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29926", "Q03100", "DDB_G0281545", "species_29926", "Q03100", "DDB_G0281545", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29420", "species_29420", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343" ] }, "reaction_10584938": { "compartment": "compartment_876", "id": "reaction_10584938", "reactome": "R-DDI-170666", "name": "Adenylate cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584931" ], "products": [ "species_29372", "species_10584935" ], "modifiers": [ [ "species_10584931", "catalyst" ] ], "additional_components": [ "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545", "species_29420", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545" ] }, "reaction_10584940": { "compartment": "compartment_876", "id": "reaction_10584940", "reactome": "R-DDI-170671", "name": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584867", "species_10584929" ], "products": [ "species_10584931" ], "modifiers": [], "additional_components": [ "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545" ] }, "reaction_10583667": { "compartment": "compartment_7660", "id": "reaction_10583667", "reactome": "R-DDI-156661", "name": "Formation of Exon Junction Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10579667", "species_10579651" ], "products": [ "species_10579671" ], "modifiers": [], "additional_components": [ "Q54ME8", "DDB_G0286007", "Q55E21", "DDB_G0270866", "Q55BF5", "DDB_G0271312", "Q86JC5", "DDB_G0275957", "Q1ZXF6", "DDB_G0284555", "Q54LY9", "DDB_G0286297", "Q54IV3", "DDB_G0288501", "Q54SA7", "DDB_G0282569", "Q54BG2", "DDB_G0293636", "Q54PP4", "DDB_G0284403", "Q54TL3", "DDB_G0281687", "Q55CI7", "DDB_G0271014", "Q54Q46", "DDB_G0284101", "Q54J05", "DDB_G0288391", "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q553B1", "DDB_G0275443", "Q54NJ4", "DDB_G0285213", "Q55BL6", "DDB_G0270450", "Q86A14", "DDB_G0272676", "Q54B65", "DDB_G0293876", "Q55CK7", "DDB_G0270020", "Q557T0", "DDB_G0273383", "Q7KWK5", "DDB_G0276803", "Q54SG7", "DDB_G0282763", "Q54WZ0", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10579612", "species_10579597", "species_10579592", "species_10579497", "species_10579607", "species_10579602", "species_10579617" ], "products": [ "species_10579055", "species_10579002", "species_10579050", "species_10579478", "species_10579623", "species_10579060", "species_10579301", "species_10578963", "species_10579473" ], "modifiers": [], "additional_components": [ "DDB_G0283901", "DDB_G0269192", "Q54V94", "DDB_G0280529", "Q54XS9", "DDB_G0278769", "Q54LG7", "DDB_G0286645", "Q54WL8", "DDB_G0279559", "Q54N48", "DDB_G0285507", "Q54J73", "DDB_G0288259", "Q55E68", "DDB_G0269370", "Q54ZS8", "DDB_G0277371", "Q55BS1", "DDB_G0270392", "Q55CA3", "DDB_G0270148", "Q54PX4", "DDB_G0284319", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797", "C7G084", "DDB_G0295793", "Q54TS6", "DDB_G0281585", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q8T295", "DDB_G0274229", "Q54ST0", "DDB_G0282243", "Q553S5", "DDB_G0275407", "Q55A15", "DDB_G0272374", "Q54R72", "DDB_G0283359", "Q55AR8", "DDB_G0271788", "Q54TF6", "DDB_G0281779", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q54XH4", "DDB_G0278929", "Q54TQ2", "DDB_G0281621", "Q54WN2", "DDB_G0279535", "Q54K20", "DDB_G0287635", "Q86J17", "DDB_G0274281", "Q8T2A7", "DDB_G0274213", "C7G068", "DDB_G0289595", "Q54HF6", "DDB_G0289499", "Q54KX4", "DDB_G0287053", "Q55EX5", "DDB_G0268716", "Q1ZXD5", "DDB_G0288479", "Q1ZXK3", "DDB_G0277107", "Q552U1", "DDB_G0275719", "Q54ZS5", "DDB_G0277375", "Q54N41", "DDB_G0285521", "Q55A46", "DDB_G0272108", "Q54E37", "DDB_G0291836", "Q54XP4", "DDB_G0278819", "Q54YA5", "DDB_G0278335", "Q55FQ0", "DDB_G0268004", "Q54J05", "DDB_G0288391", "Q55BU3", "DDB_G0270360", "Q55EN0", "DDB_G0269006", "Q54LV5", "DDB_G0286395", "Q54MH4", "DDB_G0285843", "Q54LX5", "DDB_G0286361", "Q54CE0", "DDB_G0293168", "Q1ZXB1", "DDB_G0291966", "Q54PX3", "DDB_G0291966", "Q86IV3", "DDB_G0274361", "Q54HF5", "DDB_G0289501", "Q54Z08", "DDB_G0277977", "Q55EC6", "DDB_G0269300", "P54705", "DDB_G0269188", "Q86A78", "DDB_G0274577", "Q54FZ3", "DDB_G0290649", "Q54NB4", "DDB_G0285363", "Q54NB3", "DDB_G0285363", "Q54WE9", "DDB_G0279695", "Q86I71", "DDB_G0279695", "Q54VI2", "DDB_G0280393", "Q9NI62", "DDB_G0269216", "Q557T0", "DDB_G0273383", "Q7KWK5", "DDB_G0276803", "Q54SG7", "DDB_G0282763", "Q54WZ0", "DDB_G0279311", "Q54CN1", "DDB_G0292846", "P36415", "DDB_G0269144", "Q54WP9", "DDB_G0279507", "Q54CT3", "DDB_G0292778", "Q55BF5", "DDB_G0271312", "Q86JC5", "DDB_G0275957", "Q1ZXF6", "DDB_G0284555", "Q54LY9", "DDB_G0286297", "Q54IV3", "DDB_G0288501", "Q54SA7", "DDB_G0282569", "Q54BG2", "DDB_G0293636", "Q54PP4", "DDB_G0284403", "Q54TL3", "DDB_G0281687", "Q55CI7", "DDB_G0271014", "Q54Q46", "DDB_G0284101", "Q553B1", "DDB_G0275443", "Q54NJ4", "DDB_G0285213", "Q55BL6", "DDB_G0270450", "Q86A14", "DDB_G0272676", "Q54B65", "DDB_G0293876", "Q55CK7", "DDB_G0270020", "Q54YS7", "DDB_G0278105", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54NS6", "DDB_G0285077", "Q54LT3", "DDB_G0286425", "Q55G70", "DDB_G0267796", "Q555Z2", "DDB_G0274797", "Q54PW8", "DDB_G0284321", "DDB_G0289933", "DDB_G0285937", "DDB_G0268358", "DDB_G0279535", "Q54HF6", "DDB_G0289499", "Q54KX4", "DDB_G0287053", "Q55EX5", "DDB_G0268716", "Q1ZXD5", "DDB_G0288479", "Q54TF6", "DDB_G0281779", "Q1ZXK3", "DDB_G0277107", "Q552U1", "DDB_G0275719", "DDB_G0281621", "DDB_G0286361", "Q54LT3", "DDB_G0286425", "Q54NS6", "DDB_G0285077", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55BF5", "DDB_G0271312", "Q86JC5", "DDB_G0275957", "Q1ZXF6", "DDB_G0284555", "Q54LY9", "DDB_G0286297", "Q54IV3", "DDB_G0288501", "Q54SA7", "DDB_G0282569", "Q54BG2", "DDB_G0293636", "Q54PP4", "DDB_G0284403", "Q54TL3", "DDB_G0281687", "Q55CI7", "DDB_G0271014", "Q54Q46", "DDB_G0284101", "Q54J05", "DDB_G0288391", "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q553B1", "DDB_G0275443", "Q54NJ4", "DDB_G0285213", "Q55BL6", "DDB_G0270450", "Q86A14", "DDB_G0272676", "Q54B65", "DDB_G0293876", "Q55CK7", "DDB_G0270020", "Q557T0", "DDB_G0273383", "Q7KWK5", "DDB_G0276803", "Q54SG7", "DDB_G0282763", "Q54WZ0", "DDB_G0279311", "Q54CN1", "DDB_G0292846", "P36415", "DDB_G0269144", "Q54WP9", "DDB_G0279507", "Q54CT3", "DDB_G0292778", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54ZS5", "DDB_G0277375", "Q54N41", "DDB_G0285521", "Q55A46", "DDB_G0272108", "Q54XP4", "DDB_G0278819", "Q8T295", "DDB_G0274229", "Q54ST0", "DDB_G0282243", "Q553S5", "DDB_G0275407", "Q55A15", "DDB_G0272374", "Q54R72", "DDB_G0283359", "Q55AR8", "DDB_G0271788", "Q54TF6", "DDB_G0281779", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q55BU3", "DDB_G0270360", "Q55EN0", "DDB_G0269006", "Q54QF2", "DDB_G0283901", "Q54MH4", "DDB_G0285843", "Q54LV5", "DDB_G0286395", "Q54GS9", "DDB_G0289933", "Q54MH3", "DDB_G0285937", "Q1ZXB1", "DDB_G0291966", "Q54PX3", "DDB_G0291966", "Q54HF5", "DDB_G0289501", "Q54Z08", "DDB_G0277977", "Q55EC6", "DDB_G0269300", "Q55D61", "DDB_G0269192", "Q54V94", "DDB_G0280529", "Q54XS9", "DDB_G0278769", "Q54LG7", "DDB_G0286645", "Q54WL8", "DDB_G0279559", "Q54N48", "DDB_G0285507", "Q54J73", "DDB_G0288259", "Q55E68", "DDB_G0269370", "Q54ZS8", "DDB_G0277371", "Q55BS1", "DDB_G0270392", "Q55CA3", "DDB_G0270148", "Q54PX4", "DDB_G0284319", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797", "C7G084", "DDB_G0295793", "Q54TS6", "DDB_G0281585", "P54705", "DDB_G0269188", "Q86A78", "DDB_G0274577", "Q54FZ3", "DDB_G0290649", "Q54NB4", "DDB_G0285363", "Q54NB3", "DDB_G0285363", "Q9NI62", "DDB_G0269216", "Q54E37", "DDB_G0291836", "Q54YS7", "DDB_G0278105", "Q54VI2", "DDB_G0280393", "Q54CE0", "DDB_G0293168", "Q54PW8", "DDB_G0284321", "Q54WE9", "DDB_G0279695", "Q86I71", "DDB_G0279695", "Q55G43", "DDB_G0268358", "Q55G70", "DDB_G0267796", "Q555Z2", "DDB_G0274797", "DDB_G0278929", "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q54YA5", "DDB_G0278335", "Q55FQ0", "DDB_G0268004", "Q54J05", "DDB_G0288391", "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q54K20", "DDB_G0287635", "Q86J17", "DDB_G0274281", "Q8T2A7", "DDB_G0274213", "Q54ST0", "DDB_G0282243", "C7G068", "DDB_G0289595", "DDB_G0274361" ] }, "reaction_10579630": { "compartment": "compartment_7660", "id": "reaction_10579630", "reactome": "R-DDI-72139", "name": "Formation of the active Spliceosomal C (B*) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10579623" ], "products": [ "species_10579627", "species_10579617" ], "modifiers": [ [ "species_10579623", "catalyst" ] ], "additional_components": [ "Q54LT3", "DDB_G0286425", "Q54NS6", "DDB_G0285077", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55BF5", "DDB_G0271312", "Q86JC5", "DDB_G0275957", "Q1ZXF6", "DDB_G0284555", "Q54LY9", "DDB_G0286297", "Q54IV3", "DDB_G0288501", "Q54SA7", "DDB_G0282569", "Q54BG2", "DDB_G0293636", "Q54PP4", "DDB_G0284403", "Q54TL3", "DDB_G0281687", "Q55CI7", "DDB_G0271014", "Q54Q46", "DDB_G0284101", "Q54J05", "DDB_G0288391", "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q553B1", "DDB_G0275443", "Q54NJ4", "DDB_G0285213", "Q55BL6", "DDB_G0270450", "Q86A14", "DDB_G0272676", "Q54B65", "DDB_G0293876", "Q55CK7", "DDB_G0270020", "Q557T0", "DDB_G0273383", "Q7KWK5", "DDB_G0276803", "Q54SG7", "DDB_G0282763", "Q54WZ0", "DDB_G0279311", "Q54CN1", "DDB_G0292846", "P36415", "DDB_G0269144", "Q54WP9", "DDB_G0279507", "Q54CT3", "DDB_G0292778", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54ZS5", "DDB_G0277375", "Q54N41", "DDB_G0285521", "Q55A46", "DDB_G0272108", "Q54XP4", "DDB_G0278819", "Q8T295", "DDB_G0274229", "Q54ST0", "DDB_G0282243", "Q553S5", "DDB_G0275407", "Q55A15", "DDB_G0272374", "Q54R72", "DDB_G0283359", "Q55AR8", "DDB_G0271788", "Q54TF6", "DDB_G0281779", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q55BU3", "DDB_G0270360", "Q55EN0", "DDB_G0269006", "Q54QF2", "DDB_G0283901", "Q54MH4", "DDB_G0285843", "Q54LV5", "DDB_G0286395", "Q54GS9", "DDB_G0289933", "Q54MH3", "DDB_G0285937", "Q1ZXB1", "DDB_G0291966", "Q54PX3", "DDB_G0291966", "Q54HF5", "DDB_G0289501", "Q54Z08", "DDB_G0277977", "Q55EC6", "DDB_G0269300", "Q55D61", "DDB_G0269192", "Q54V94", "DDB_G0280529", "Q54XS9", "DDB_G0278769", "Q54LG7", "DDB_G0286645", "Q54WL8", "DDB_G0279559", "Q54N48", "DDB_G0285507", "Q54J73", "DDB_G0288259", "Q55E68", "DDB_G0269370", "Q54ZS8", "DDB_G0277371", "Q55BS1", "DDB_G0270392", "Q55CA3", "DDB_G0270148", "Q54PX4", "DDB_G0284319", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797", "C7G084", "DDB_G0295793", "Q54TS6", "DDB_G0281585", "P54705", "DDB_G0269188", "Q86A78", "DDB_G0274577", "Q54FZ3", "DDB_G0290649", "Q54NB4", "DDB_G0285363", "Q54NB3", "DDB_G0285363", "Q9NI62", "DDB_G0269216", "Q54E37", "DDB_G0291836", "Q54YS7", "DDB_G0278105", "Q54VI2", "DDB_G0280393", "Q54CE0", "DDB_G0293168", "Q54PW8", "DDB_G0284321", "Q54WE9", "DDB_G0279695", "Q86I71", "DDB_G0279695", "Q55G43", "DDB_G0268358", "Q55G70", "DDB_G0267796", "Q555Z2", "DDB_G0274797", "Q55G70", "DDB_G0267796", "Q54LT3", "DDB_G0286425", "Q54NS6", "DDB_G0285077", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55BF5", "DDB_G0271312", "Q86JC5", "DDB_G0275957", "Q1ZXF6", "DDB_G0284555", "Q54LY9", "DDB_G0286297", "Q54IV3", "DDB_G0288501", "Q54SA7", "DDB_G0282569", "Q54BG2", "DDB_G0293636", "Q54PP4", "DDB_G0284403", "Q54TL3", "DDB_G0281687", "Q55CI7", "DDB_G0271014", "Q54Q46", "DDB_G0284101", "Q54J05", "DDB_G0288391", "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q553B1", "DDB_G0275443", "Q54NJ4", "DDB_G0285213", "Q55BL6", "DDB_G0270450", "Q86A14", "DDB_G0272676", "Q54B65", "DDB_G0293876", "Q55CK7", "DDB_G0270020", "Q557T0", "DDB_G0273383", "Q7KWK5", "DDB_G0276803", "Q54SG7", "DDB_G0282763", "Q54WZ0", "DDB_G0279311", "Q54CN1", "DDB_G0292846", "P36415", "DDB_G0269144", "Q54WP9", "DDB_G0279507", "Q54CT3", "DDB_G0292778", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54ZS5", "DDB_G0277375", "Q54N41", "DDB_G0285521", "Q55A46", "DDB_G0272108", "Q54XP4", "DDB_G0278819", "Q8T295", "DDB_G0274229", "Q54ST0", "DDB_G0282243", "Q553S5", "DDB_G0275407", "Q55A15", "DDB_G0272374", "Q54R72", "DDB_G0283359", "Q55AR8", "DDB_G0271788", "Q54TF6", "DDB_G0281779", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q55BU3", "DDB_G0270360", "Q55EN0", "DDB_G0269006", "Q54QF2", "DDB_G0283901", "Q54MH4", "DDB_G0285843", "Q54LV5", "DDB_G0286395", "Q54GS9", "DDB_G0289933", "Q54MH3", "DDB_G0285937", "Q1ZXB1", "DDB_G0291966", "Q54PX3", "DDB_G0291966", "Q54HF5", "DDB_G0289501", "Q54Z08", "DDB_G0277977", "Q55EC6", "DDB_G0269300", "Q55D61", "DDB_G0269192", "Q54V94", "DDB_G0280529", "Q54XS9", "DDB_G0278769", "Q54LG7", "DDB_G0286645", "Q54WL8", "DDB_G0279559", "Q54N48", "DDB_G0285507", "Q54J73", "DDB_G0288259", "Q55E68", "DDB_G0269370", "Q54ZS8", "DDB_G0277371", "Q55BS1", "DDB_G0270392", "Q55CA3", "DDB_G0270148", "Q54PX4", "DDB_G0284319", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797", "C7G084", "DDB_G0295793", "Q54TS6", "DDB_G0281585", "P54705", "DDB_G0269188", "Q86A78", "DDB_G0274577", "Q54FZ3", "DDB_G0290649", "Q54NB4", "DDB_G0285363", "Q54NB3", "DDB_G0285363", "Q9NI62", "DDB_G0269216", "Q54E37", "DDB_G0291836", "Q54YS7", "DDB_G0278105", "Q54VI2", "DDB_G0280393", "Q54CE0", "DDB_G0293168", "Q54PW8", "DDB_G0284321", "Q54WE9", "DDB_G0279695", "Q86I71", "DDB_G0279695", "Q555Z2", "DDB_G0274797", "DDB_G0268358", "Q54LT3", "DDB_G0286425", "Q54NS6", "DDB_G0285077", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55BF5", "DDB_G0271312", "Q86JC5", "DDB_G0275957", "Q1ZXF6", "DDB_G0284555", "Q54LY9", "DDB_G0286297", "Q54IV3", "DDB_G0288501", "Q54SA7", "DDB_G0282569", "Q54BG2", "DDB_G0293636", "Q54PP4", "DDB_G0284403", "Q54TL3", "DDB_G0281687", "Q55CI7", "DDB_G0271014", "Q54Q46", "DDB_G0284101", "Q54J05", "DDB_G0288391", "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q553B1", "DDB_G0275443", "Q54NJ4", "DDB_G0285213", "Q55BL6", "DDB_G0270450", "Q86A14", "DDB_G0272676", "Q54B65", "DDB_G0293876", "Q55CK7", "DDB_G0270020", "Q557T0", "DDB_G0273383", "Q7KWK5", "DDB_G0276803", "Q54SG7", "DDB_G0282763", "Q54WZ0", "DDB_G0279311", "Q54CN1", "DDB_G0292846", "P36415", "DDB_G0269144", "Q54WP9", "DDB_G0279507", "Q54CT3", "DDB_G0292778", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54ZS5", "DDB_G0277375", "Q54N41", "DDB_G0285521", "Q55A46", "DDB_G0272108", "Q54XP4", "DDB_G0278819", "Q8T295", "DDB_G0274229", "Q54ST0", "DDB_G0282243", "Q553S5", "DDB_G0275407", "Q55A15", "DDB_G0272374", "Q54R72", "DDB_G0283359", "Q55AR8", "DDB_G0271788", "Q54TF6", "DDB_G0281779", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q55BU3", "DDB_G0270360", "Q55EN0", "DDB_G0269006", "Q54QF2", "DDB_G0283901", "Q54MH4", "DDB_G0285843", "Q54LV5", "DDB_G0286395", "Q54GS9", "DDB_G0289933", "Q54MH3", "DDB_G0285937", "Q1ZXB1", "DDB_G0291966", "Q54PX3", "DDB_G0291966", "Q54HF5", "DDB_G0289501", "Q54Z08", "DDB_G0277977", "Q55EC6", "DDB_G0269300", "Q55D61", "DDB_G0269192", "Q54V94", "DDB_G0280529", "Q54XS9", "DDB_G0278769", "Q54LG7", "DDB_G0286645", "Q54WL8", "DDB_G0279559", "Q54N48", "DDB_G0285507", "Q54J73", "DDB_G0288259", "Q55E68", "DDB_G0269370", "Q54ZS8", "DDB_G0277371", "Q55BS1", "DDB_G0270392", "Q55CA3", "DDB_G0270148", "Q54PX4", "DDB_G0284319", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797", "C7G084", "DDB_G0295793", "Q54TS6", "DDB_G0281585", "P54705", "DDB_G0269188", "Q86A78", "DDB_G0274577", "Q54FZ3", "DDB_G0290649", "Q54NB4", "DDB_G0285363", "Q54NB3", "DDB_G0285363", "Q9NI62", "DDB_G0269216", "Q54E37", "DDB_G0291836", "Q54YS7", "DDB_G0278105", "Q54VI2", "DDB_G0280393", "Q54CE0", "DDB_G0293168", "Q54PW8", "DDB_G0284321", "Q54WE9", "DDB_G0279695", "Q86I71", "DDB_G0279695", "Q55G43", "DDB_G0268358", "Q55G70", "DDB_G0267796", "Q555Z2", "DDB_G0274797" ] }, "reaction_10581544": { "compartment": "compartment_7660", "id": "reaction_10581544", "reactome": "R-DDI-75079", "name": "Formation of AT-AC C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581540" ], "products": [ "species_10581532", "species_10581542" ], "modifiers": [], "additional_components": [ "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q8T295", "DDB_G0274229", "Q54ST0", "DDB_G0282243", "Q553S5", "DDB_G0275407", "Q55A15", "DDB_G0272374", "Q54R72", "DDB_G0283359", "Q55AR8", "DDB_G0271788", "Q54TF6", "DDB_G0281779", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q1ZXB1", "DDB_G0291966", "Q54PX3", "DDB_G0291966", "Q55BF5", "DDB_G0271312", "Q86JC5", "DDB_G0275957", "Q1ZXF6", "DDB_G0284555", "Q54LY9", "DDB_G0286297", "Q54IV3", "DDB_G0288501", "Q54SA7", "DDB_G0282569", "Q55CC1", "DDB_G0270734", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q1ZXB1", "DDB_G0291966", "Q54PX3", "DDB_G0291966", "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q8T295", "DDB_G0274229", "Q54ST0", "DDB_G0282243", "Q553S5", "DDB_G0275407", "Q55A15", "DDB_G0272374", "Q54R72", "DDB_G0283359", "Q55AR8", "DDB_G0271788", "Q54TF6", "DDB_G0281779", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q55BF5", "DDB_G0271312", "Q86JC5", "DDB_G0275957", "Q1ZXF6", "DDB_G0284555", "Q54LY9", "DDB_G0286297", "Q54IV3", "DDB_G0288501", "Q54SA7", "DDB_G0282569", "Q55CC1", "DDB_G0270734", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10581546": { "compartment": "compartment_7660", "id": "reaction_10581546", "reactome": "R-DDI-75082", "name": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581542" ], "products": [ "species_10581542" ], "modifiers": [], "additional_components": [ "Q1ZXB1", "DDB_G0291966", "Q54PX3", "DDB_G0291966", "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q8T295", "DDB_G0274229", "Q54ST0", "DDB_G0282243", "Q553S5", "DDB_G0275407", "Q55A15", "DDB_G0272374", "Q54R72", "DDB_G0283359", "Q55AR8", "DDB_G0271788", "Q54TF6", "DDB_G0281779", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q55BF5", "DDB_G0271312", "Q86JC5", "DDB_G0275957", "Q1ZXF6", "DDB_G0284555", "Q54LY9", "DDB_G0286297", "Q54IV3", "DDB_G0288501", "Q54SA7", "DDB_G0282569", "Q55CC1", "DDB_G0270734", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q1ZXB1", "DDB_G0291966", "Q54PX3", "DDB_G0291966", "C7G054", "DDB_G0302414", "Q54YX5", "DDB_G0278027", "Q54XP2", "DDB_G0278821", "Q86L45", "DDB_G0273003", "Q54NC5", "DDB_G0285395", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "Q8T295", "DDB_G0274229", "Q54ST0", "DDB_G0282243", "Q553S5", "DDB_G0275407", "Q55A15", "DDB_G0272374", "Q54R72", "DDB_G0283359", "Q55AR8", "DDB_G0271788", "Q54TF6", "DDB_G0281779", "Q54Y81", "DDB_G0277857", "Q55CI8", "DDB_G0270042", "Q55BF5", "DDB_G0271312", "Q86JC5", "DDB_G0275957", "Q1ZXF6", "DDB_G0284555", "Q54LY9", "DDB_G0286297", "Q54IV3", "DDB_G0288501", "Q54SA7", "DDB_G0282569", "Q55CC1", "DDB_G0270734", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10590100": { "compartment": "compartment_876", "id": "reaction_10590100", "reactome": "R-DDI-381608", "name": "cAMP activates EPAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10590096" ], "products": [ "species_10590098" ], "modifiers": [], "additional_components": [ "Q54TK8", "DDB_G0281573", "Q8IS12", "DDB_G0275703", "Q54TK8", "DDB_G0281573", "Q8IS12", "DDB_G0275703", "species_30389" ] }, "reaction_10590135": { "compartment": "compartment_876", "id": "reaction_10590135", "reactome": "R-DDI-381668", "name": "cAMP activates EPAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10590131" ], "products": [ "species_10590133" ], "modifiers": [], "additional_components": [ "Q8IS12", "DDB_G0275703", "Q54TK8", "DDB_G0281573", "Q8IS12", "DDB_G0275703", "Q54TK8", "DDB_G0281573", "species_30389" ] }, "reaction_10590141": { "compartment": "compartment_70101", "id": "reaction_10590141", "reactome": "R-DDI-381727", "name": "RAP1A exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10590137" ], "products": [ "species_29420", "species_10590139" ], "modifiers": [ [ "species_10590133", "catalyst" ], [ "species_10590098", "catalyst" ] ], "additional_components": [ "species_29420", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "species_29438", "Q8IS12", "DDB_G0275703", "Q54TK8", "DDB_G0281573", "species_30389", "Q54TK8", "DDB_G0281573", "Q8IS12", "DDB_G0275703", "species_30389" ] }, "reaction_10590124": { "compartment": "compartment_12045", "id": "reaction_10590124", "reactome": "R-DDI-381644", "name": "ER calcium channels open in response to activated PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590114" ], "products": [ "species_10590122" ], "modifiers": [ [ "species_10582991", "catalyst" ] ], "additional_components": [ "Q9NA13", "DDB_G0292564", "Q9NA13", "DDB_G0292564", "species_114520", "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029" ] }, "reaction_10586788": { "compartment": "compartment_70101", "id": "reaction_10586788", "reactome": "R-DDI-196402", "name": "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_195655", "species_29364" ], "products": [ "species_29366", "species_196420" ], "modifiers": [ [ "species_10586785", "catalyst" ] ], "additional_components": [ "DDB_G0284407" ] }, "reaction_10586760": { "compartment": "compartment_12045", "id": "reaction_10586760", "reactome": "R-DDI-195690", "name": "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194691" ], "products": [ "species_195691" ], "modifiers": [ [ "species_10586757", "catalyst" ] ], "additional_components": [ "DDB_G0269414" ] }, "reaction_10627239": { "compartment": "compartment_984", "id": "reaction_10627239", "reactome": "R-DDI-9673054", "name": "PM20D1 hydrolyzes oleoyl-phe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_9673044" ], "products": [ "species_351993", "species_9673048" ], "modifiers": [ [ "species_10627234", "catalyst" ] ], "additional_components": [ "DDB_G0270582" ] }, "reaction_10627237": { "compartment": "compartment_984", "id": "reaction_10627237", "reactome": "R-DDI-9673053", "name": "PM20D1 transforms oleoyl-phe from oleate and phe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351993", "species_9673048" ], "products": [ "species_109276", "species_9673044" ], "modifiers": [ [ "species_10627234", "catalyst" ] ], "additional_components": [ "DDB_G0270582" ] }, "reaction_10594189": { "compartment": "compartment_70101", "id": "reaction_10594189", "reactome": "R-DDI-874087", "name": "SGT1 binds HSP90", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594185", "species_10594183" ], "products": [ "species_10594187" ], "modifiers": [], "additional_components": [ "DDB_G0267400", "DDB_G0269292", "Q55ED0", "DDB_G0269292", "P54651", "DDB_G0267400" ] }, "reaction_10590742": { "compartment": "compartment_876", "id": "reaction_10590742", "reactome": "R-DDI-418309", "name": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016" ], "products": [ "species_74112" ], "modifiers": [ [ "species_10590739", "catalyst" ] ], "additional_components": [ "P54678", "DDB_G0277861", "Q54HG6", "DDB_G0289473", "Q54PE8", "DDB_G0289473" ] }, "reaction_10613009": { "compartment": "compartment_7660", "id": "reaction_10613009", "reactome": "R-DDI-6791219", "name": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612993" ], "products": [ "species_10612972" ], "modifiers": [ [ "species_10612963", "catalyst" ], [ "species_10612968", "catalyst" ], [ "species_10613007", "catalyst" ], [ "species_10612991", "catalyst" ] ], "additional_components": [ "Q75JW2", "DDB_G0272176", "Q54Z27", "DDB_G0277945", "Q54DG4", "DDB_G0292290", "Q54W97", "DDB_G0279809", "Q55DQ9", "DDB_G0270828", "Q54IM3", "DDB_G0288659", "Q54TD8", "DDB_G0281839", "Q54HJ2", "DDB_G0289415", "Q54W52", "DDB_G0279903", "Q75JW2", "DDB_G0272176", "Q54Z27", "DDB_G0277945", "Q54DG4", "DDB_G0292290", "Q54W97", "DDB_G0279809", "Q55DQ9", "DDB_G0270828", "Q54IM3", "DDB_G0288659", "DDB_G0272176", "DDB_G0277945", "Q54P34", "DDB_G0284817", "Q54HJ2", "DDB_G0289415", "Q54KS4", "DDB_G0287147", "Q54TD8", "DDB_G0281839", "Q54HJ2", "DDB_G0289415", "Q54W52", "DDB_G0279903" ] }, "reaction_10613443": { "compartment": "compartment_70101", "id": "reaction_10613443", "reactome": "R-DDI-6791223", "name": "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613417", "species_10613415" ], "products": [ "species_10613423", "species_10613421", "species_10613435", "species_10613419", "species_10613433", "species_10613417", "species_10579913", "species_10613431", "species_10613429", "species_10613427", "species_10613425" ], "modifiers": [ [ "species_10613423", "catalyst" ], [ "species_10613433", "catalyst" ], [ "species_10613441", "catalyst" ], [ "species_10613435", "catalyst" ] ], "additional_components": [ "DDB_G0280431", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "P90526", "DDB_G0293000", "P14132", "DDB_G0289877", "Q76P36", "DDB_G0272308", "Q54U04", "DDB_G0281409", "Q54I41", "DDB_G0289025", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "Q54UU3", "DDB_G0280823", "Q54GC0", "DDB_G0290281", "P27685", "DDB_G0293742", "Q556Y4", "DDB_G0273059", "Q54TL8", "DDB_G0281677", "Q03409", "DDB_G0271148", "Q54VD8", "DDB_G0280431", "Q54BN4", "DDB_G0293700", "Q54YA7", "DDB_G0278331", "Q54Y41", "DDB_G0278429", "Q54X51", "DDB_G0279207", "Q869U7", "DDB_G0276415", "P42520", "DDB_G0290141", "Q54T05", "DDB_G0282099", "Q54N17", "DDB_G0285561", "Q54K66", "DDB_G0287557", "Q54PX9", "DDB_G0284237", "O77082", "DDB_G0286117", "Q54E24", "DDB_G0291864", "Q54MA6", "DDB_G0286075", "Q54W91", "DDB_G0279821", "Q54ZW5", "DDB_G0277345", "Q75K27", "DDB_G0275473", "Q8T1D4", "DDB_G0275601", "Q8T1V4", "DDB_G0277635", "Q54MZ5", "DDB_G0285597", "Q55A19", "DDB_G0272250", "Q54Q51", "DDB_G0284093", "P46793", "DDB_G0276457", "Q54IS0", "DDB_G0288565", "Q54PH8", "DDB_G0284533", "Q54S90", "DDB_G0282601", "Q54W23", "DDB_G0279961", "P51405", "DDB_G0272825", "Q3ZE13", "DDB_G0269980", "DDB_G0279821", "DDB_G0275601", "DDB_G0273059", "DDB_G0288565", "DDB_G0273059", "DDB_G0280431", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "DDB_G0280431", "DDB_G0278331", "DDB_G0282099", "DDB_G0287557", "DDB_G0279821", "DDB_G0273059", "DDB_G0269722", "DDB_G0273059" ] }, "reaction_10613285": { "compartment": "compartment_7660", "id": "reaction_10613285", "reactome": "R-DDI-6791222", "name": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613233" ], "products": [ "species_10613241" ], "modifiers": [ [ "species_10613282", "catalyst" ], [ "species_10613246", "catalyst" ], [ "species_10613265", "catalyst" ], [ "species_10613280", "catalyst" ] ], "additional_components": [ "Q54JS8", "DDB_G0287891", "Q54S38", "DDB_G0282803", "Q553S0", "DDB_G0275403", "Q54WV7", "DDB_G0279371", "Q55GM5", "DDB_G0267606", "Q54HT2", "DDB_G0289235", "Q54X28", "DDB_G0279245", "Q54XG2", "DDB_G0278983", "C7G018", "DDB_G0302418", "Q54KG8", "DDB_G0287351", "Q7KWM6", "DDB_G0272732", "Q55BA1", "DDB_G0271240", "Q54PE0", "DDB_G0284621", "Q54WN5", "DDB_G0279601", "Q550V0", "DDB_G0277019", "Q54S79", "DDB_G0282623", "Q7KWS8", "DDB_G0276283", "Q54UU6", "DDB_G0280805", "Q86IZ9", "DDB_G0274325", "Q54BV0", "DDB_G0293412", "Q54ST0", "DDB_G0282243", "Q55CW0", "DDB_G0269878", "Q55FI4", "DDB_G0268098", "Q54MT2", "DDB_G0285679", "Q54VT4", "DDB_G0280147", "Q54EN2", "DDB_G0291438", "Q54XT8", "DDB_G0278751", "Q55D06", "DDB_G0269830", "Q54GG4", "DDB_G0290181", "Q54K79", "DDB_G0287537", "Q7KWL3", "DDB_G0276815", "P27685", "DDB_G0293742", "Q54VA5", "DDB_G0280489", "Q54UU3", "DDB_G0280823", "Q54I41", "DDB_G0289025", "P14132", "DDB_G0289877", "Q8T2Q3", "DDB_G0275141", "Q55EH5", "DDB_G0268898", "Q54QV4", "DDB_G0283581", "Q54ML4", "DDB_G0285875", "Q55C50", "DDB_G0270230", "Q54EG3", "DDB_G0291526", "Q54JS8", "DDB_G0287891", "Q54S38", "DDB_G0282803", "Q553S0", "DDB_G0275403", "Q54WV7", "DDB_G0279371", "Q55GM5", "DDB_G0267606", "Q54HT2", "DDB_G0289235", "Q54X28", "DDB_G0279245", "Q54XG2", "DDB_G0278983", "C7G018", "DDB_G0302418", "Q54KG8", "DDB_G0287351", "Q7KWM6", "DDB_G0272732", "Q55BA1", "DDB_G0271240", "Q54PE0", "DDB_G0284621", "Q54WN5", "DDB_G0279601", "Q550V0", "DDB_G0277019", "Q54S79", "DDB_G0282623", "Q7KWS8", "DDB_G0276283", "Q54UU6", "DDB_G0280805", "Q86IZ9", "DDB_G0274325", "Q54BV0", "DDB_G0293412", "Q54ST0", "DDB_G0282243", "Q55CW0", "DDB_G0269878", "Q55FI4", "DDB_G0268098", "Q54MT2", "DDB_G0285679", "Q54VT4", "DDB_G0280147", "Q54EN2", "DDB_G0291438", "Q54XT8", "DDB_G0278751", "Q55D06", "DDB_G0269830", "Q54GG4", "DDB_G0290181", "Q54K79", "DDB_G0287537", "Q7KWL3", "DDB_G0276815", "P27685", "DDB_G0293742", "Q54VA5", "DDB_G0280489", "Q54UU3", "DDB_G0280823", "Q54I41", "DDB_G0289025", "P14132", "DDB_G0289877", "Q8T2Q3", "DDB_G0275141", "Q55EH5", "DDB_G0268898", "Q54QV4", "DDB_G0283581", "Q54ML4", "DDB_G0285875", "Q55C50", "DDB_G0270230", "Q54EG3", "DDB_G0291526", "Q86IE2", "DDB_G0275633", "Q54ZS3", "DDB_G0277279", "Q55AW0", "DDB_G0271572", "Q54Q83", "DDB_G0284053", "Q55BB0", "DDB_G0271396", "Q54VM4", "DDB_G0280251", "Q54CU6", "DDB_G0292692", "Q54N99", "DDB_G0285377", "Q55BJ2", "DDB_G0271100", "Q54EV5", "DDB_G0291310", "Q7KWX9", "DDB_G0276783", "Q54EU6", "DDB_G0291328", "DDB_G0271572", "DDB_G0284053", "DDB_G0275633" ] }, "reaction_10613464": { "compartment": "compartment_7660", "id": "reaction_10613464", "reactome": "R-DDI-6791227", "name": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613450" ], "products": [ "species_10613454" ], "modifiers": [ [ "species_10613459", "catalyst" ], [ "species_10613107", "catalyst" ], [ "species_10613131", "catalyst" ], [ "species_10613462", "catalyst" ], [ "species_10613085", "catalyst" ], [ "species_10613280", "catalyst" ] ], "additional_components": [ "Q54JS8", "DDB_G0287891", "Q54S38", "DDB_G0282803", "Q553S0", "DDB_G0275403", "Q54WV7", "DDB_G0279371", "Q55GM5", "DDB_G0267606", "Q54HT2", "DDB_G0289235", "Q54X28", "DDB_G0279245", "Q54XG2", "DDB_G0278983", "C7G018", "DDB_G0302418", "Q54KG8", "DDB_G0287351", "Q7KWM6", "DDB_G0272732", "Q55BA1", "DDB_G0271240", "Q54PE0", "DDB_G0284621", "Q54WN5", "DDB_G0279601", "Q550V0", "DDB_G0277019", "Q54S79", "DDB_G0282623", "Q7KWS8", "DDB_G0276283", "Q54UU6", "DDB_G0280805", "Q86IZ9", "DDB_G0274325", "Q54BV0", "DDB_G0293412", "Q54ST0", "DDB_G0282243", "Q55CW0", "DDB_G0269878", "Q55FI4", "DDB_G0268098", "Q54MT2", "DDB_G0285679", "Q54VT4", "DDB_G0280147", "Q54EN2", "DDB_G0291438", "Q54XT8", "DDB_G0278751", "Q55D06", "DDB_G0269830", "Q54GG4", "DDB_G0290181", "Q54K79", "DDB_G0287537", "Q7KWL3", "DDB_G0276815", "P27685", "DDB_G0293742", "Q54VA5", "DDB_G0280489", "Q54UU3", "DDB_G0280823", "Q54I41", "DDB_G0289025", "P14132", "DDB_G0289877", "Q8T2Q3", "DDB_G0275141", "Q55EH5", "DDB_G0268898", "Q54QV4", "DDB_G0283581", "Q54ML4", "DDB_G0285875", "Q55C50", "DDB_G0270230", "Q54EG3", "DDB_G0291526", "Q54JS8", "DDB_G0287891", "Q54S38", "DDB_G0282803", "Q553S0", "DDB_G0275403", "Q54WV7", "DDB_G0279371", "Q55GM5", "DDB_G0267606", "Q54HT2", "DDB_G0289235", "Q54X28", "DDB_G0279245", "Q54XG2", "DDB_G0278983", "C7G018", "DDB_G0302418", "Q54KG8", "DDB_G0287351", "Q7KWM6", "DDB_G0272732", "Q55BA1", "DDB_G0271240", "Q54PE0", "DDB_G0284621", "Q54WN5", "DDB_G0279601", "Q550V0", "DDB_G0277019", "Q54S79", "DDB_G0282623", "Q7KWS8", "DDB_G0276283", "Q54UU6", "DDB_G0280805", "Q86IZ9", "DDB_G0274325", "Q54BV0", "DDB_G0293412", "Q54ST0", "DDB_G0282243", "Q55CW0", "DDB_G0269878", "Q55FI4", "DDB_G0268098", "Q54MT2", "DDB_G0285679", "Q54VT4", "DDB_G0280147", "Q54EN2", "DDB_G0291438", "Q54XT8", "DDB_G0278751", "Q55D06", "DDB_G0269830", "Q54GG4", "DDB_G0290181", "Q54K79", "DDB_G0287537", "Q7KWL3", "DDB_G0276815", "P27685", "DDB_G0293742", "Q54VA5", "DDB_G0280489", "Q54UU3", "DDB_G0280823", "Q54I41", "DDB_G0289025", "P14132", "DDB_G0289877", "Q8T2Q3", "DDB_G0275141", "Q55EH5", "DDB_G0268898", "Q54QV4", "DDB_G0283581", "Q54ML4", "DDB_G0285875", "Q55C50", "DDB_G0270230", "Q54EG3", "DDB_G0291526", "DDB_G0269922", "DDB_G0271240", "Q54EN2", "DDB_G0291438", "Q54XT8", "DDB_G0278751", "Q55D06", "DDB_G0269830", "DDB_G0291836", "Q8T2Q3", "DDB_G0275141", "Q55EH5", "DDB_G0268898", "Q54QV4", "DDB_G0283581", "Q54ML4", "DDB_G0285875", "DDB_G0275633" ] }, "reaction_10590291": { "compartment": "compartment_17951", "id": "reaction_10590291", "reactome": "R-DDI-389550", "name": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389548", "species_389556" ], "products": [ "species_193465", "species_389536", "species_389537", "species_113602" ], "modifiers": [ [ "species_10590288", "catalyst" ] ], "additional_components": [ "Q75JR2", "DDB_G0272210" ] }, "reaction_10617763": { "compartment": "compartment_70101", "id": "reaction_10617763", "reactome": "R-DDI-6811504", "name": "AKT1 dephosphorylation by PP2A-B56-beta,gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10586949" ], "products": [ "species_10590479", "species_29372" ], "modifiers": [ [ "species_10617760", "catalyst" ], [ "species_1806240", "inhibitor" ] ], "additional_components": [ "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "Q54VB6", "DDB_G0280469" ] }, "reaction_10598646": { "compartment": "compartment_876", "id": "reaction_10598646", "reactome": "R-DDI-1675776", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806240", "species_113592" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10598643", "catalyst" ] ], "additional_components": [ "Q86D86", "DDB_G0283615", "Q54DL4", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635" ] }, "reaction_10599019": { "compartment": "compartment_876", "id": "reaction_10599019", "reactome": "R-DDI-1676082", "name": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10598592", "catalyst" ] ], "additional_components": [ "Q54M96", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635", "Q54VR4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q86D86", "DDB_G0283615", "Q54DL4", "DDB_G0292190" ] }, "reaction_10611344": { "compartment": "compartment_7660", "id": "reaction_10611344", "reactome": "R-DDI-5693533", "name": "DCLRE1C (ARTEMIS) processes DNA DSB ends", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608592" ], "products": [ "species_10611341" ], "modifiers": [ [ "species_10608592", "catalyst" ] ], "additional_components": [ "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303" ] }, "reaction_10611360": { "compartment": "compartment_7660", "id": "reaction_10611360", "reactome": "R-DDI-5693574", "name": "XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611358", "species_10608604", "species_10608613", "species_10608611" ], "products": [ "species_10608617" ], "modifiers": [], "additional_components": [ "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54CR9", "DDB_G0292760", "Q54YJ7", "DDB_G0278203", "DDB_G0284713", "Q54P54", "DDB_G0284785", "Q54P54", "DDB_G0284785", "Q1ZXF2", "DDB_G0284713", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54CR9", "DDB_G0292760", "Q54YJ7", "DDB_G0278203" ] }, "reaction_10608595": { "compartment": "compartment_7660", "id": "reaction_10608595", "reactome": "R-DDI-5687183", "name": "PRKDC phosphorylates DCLRE1C at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10608588" ], "products": [ "species_113582", "species_10608592" ], "modifiers": [ [ "species_10608588", "catalyst" ] ], "additional_components": [ "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303" ] }, "reaction_10611369": { "compartment": "compartment_7660", "id": "reaction_10611369", "reactome": "R-DDI-5693575", "name": "DNA-PKcs autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611366" ], "products": [ "species_113582", "species_10608586" ], "modifiers": [ [ "species_10611366", "catalyst" ] ], "additional_components": [ "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303" ] }, "reaction_10611384": { "compartment": "compartment_7660", "id": "reaction_10611384", "reactome": "R-DDI-5693578", "name": "TDP1 and TDP2 process unligatable DSB ends", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611341" ], "products": [ "species_10611358" ], "modifiers": [ [ "species_10611381", "catalyst" ] ], "additional_components": [ "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303" ] }, "reaction_10611390": { "compartment": "compartment_7660", "id": "reaction_10611390", "reactome": "R-DDI-5693615", "name": "Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611388", "species_10611362" ], "products": [ "species_10611366" ], "modifiers": [], "additional_components": [ "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "DDB_G0281167", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303" ] }, "reaction_10608622": { "compartment": "compartment_7660", "id": "reaction_10608622", "reactome": "R-DDI-5687360", "name": "POLL or POLM extends aligned DNA DSB ends to fill gaps", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10608617" ], "products": [ "species_10608619", "species_113541" ], "modifiers": [ [ "species_10608617", "catalyst" ] ], "additional_components": [ "Q54P54", "DDB_G0284785", "Q1ZXF2", "DDB_G0284713", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54CR9", "DDB_G0292760", "Q54YJ7", "DDB_G0278203", "Q54P54", "DDB_G0284785", "Q1ZXF2", "DDB_G0284713", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54CR9", "DDB_G0292760", "Q54YJ7", "DDB_G0278203", "Q54P54", "DDB_G0284785", "Q1ZXF2", "DDB_G0284713", "Q54UC0", "DDB_G0281167", "Q54MA9", "DDB_G0286069", "Q54LY5", "DDB_G0286303", "Q54CR9", "DDB_G0292760", "Q54YJ7", "DDB_G0278203" ] }, "reaction_10599936": { "compartment": "compartment_70101", "id": "reaction_10599936", "reactome": "R-DDI-2029456", "name": "RAC1 and CDC42 activate PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590366", "species_10583374" ], "products": [ "species_10590364", "species_10599932" ], "modifiers": [], "additional_components": [ "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "P34144", "DDB_G0277869", "species_29438", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10600039": { "compartment": "compartment_70101", "id": "reaction_10600039", "reactome": "R-DDI-2029473", "name": "Branching and elongation of mother and daughter filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600037", "species_10587698" ], "products": [ "species_10599621" ], "modifiers": [], "additional_components": [ "O96626", "DDB_G0288319", "O96622", "DDB_G0277825", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54L54", "DDB_G0286893", "species_29370", "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54L54", "DDB_G0286893", "species_113592", "O96626", "DDB_G0288319", "O96622", "DDB_G0277825", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54L54", "DDB_G0286893" ] }, "reaction_10599993": { "compartment": "compartment_70101", "id": "reaction_10599993", "reactome": "R-DDI-2029466", "name": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599576", "species_10599989" ], "products": [ "species_10599991" ], "modifiers": [], "additional_components": [ "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54L54", "DDB_G0286893", "species_113592", "O96626", "DDB_G0288319", "O96622", "DDB_G0277825", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "species_179838", "Q869Q3", "DDB_G0274519", "Q55FT9", "DDB_G0267956", "Q54X65", "DDB_G0279175", "Q6UK63", "DDB_G0287855", "P34144", "DDB_G0277869", "species_29438", "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54L54", "DDB_G0286893", "O96626", "DDB_G0288319", "O96622", "DDB_G0277825", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "species_179838", "Q869Q3", "DDB_G0274519", "Q55FT9", "DDB_G0267956", "Q54X65", "DDB_G0279175", "Q6UK63", "DDB_G0287855", "P34144", "DDB_G0277869", "species_29438", "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54L54", "DDB_G0286893" ] }, "reaction_10600666": { "compartment": "compartment_70101", "id": "reaction_10600666", "reactome": "R-DDI-2197690", "name": "Detachment of WASP/WAVE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599991" ], "products": [ "species_10600037", "species_10599987" ], "modifiers": [], "additional_components": [ "O96626", "DDB_G0288319", "O96622", "DDB_G0277825", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "species_179838", "Q869Q3", "DDB_G0274519", "Q55FT9", "DDB_G0267956", "Q54X65", "DDB_G0279175", "Q6UK63", "DDB_G0287855", "P34144", "DDB_G0277869", "species_29438", "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54L54", "DDB_G0286893", "O96626", "DDB_G0288319", "O96622", "DDB_G0277825", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54L54", "DDB_G0286893", "species_29370", "species_179838", "Q869Q3", "DDB_G0274519", "Q55FT9", "DDB_G0267956", "Q54X65", "DDB_G0279175", "Q6UK63", "DDB_G0287855", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10599934": { "compartment": "compartment_70101", "id": "reaction_10599934", "reactome": "R-DDI-2029454", "name": "Autophosphorylation of PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599932", "species_113592" ], "products": [ "species_10583374", "species_29370", "species_10592613" ], "modifiers": [ [ "species_10590364", "catalyst" ] ], "additional_components": [ "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "P34144", "DDB_G0277869", "species_29438", "P34144", "DDB_G0277869", "species_29438", "Q869N2", "DDB_G0276459", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459" ] }, "reaction_10622818": { "compartment": "compartment_70101", "id": "reaction_10622818", "reactome": "R-DDI-8931974", "name": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583736", "species_71284" ], "products": [ "species_10622810", "species_71285" ], "modifiers": [ [ "species_10622815", "catalyst" ] ], "additional_components": [ "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "DDB_G0272708" ] }, "reaction_10622855": { "compartment": "compartment_70101", "id": "reaction_10622855", "reactome": "R-DDI-8932276", "name": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605038", "species_71284" ], "products": [ "species_10622843", "species_71285" ], "modifiers": [ [ "species_10622852", "catalyst" ] ], "additional_components": [ "DDB_G0288065", "DDB_G0288065", "Q54UI5", "DDB_G0288643", "Q54IN5", "DDB_G0288643" ] }, "reaction_10622829": { "compartment": "compartment_7660", "id": "reaction_10622829", "reactome": "R-DDI-8932221", "name": "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10579254" ], "products": [ "species_77502", "species_10622821" ], "modifiers": [ [ "species_10622826", "catalyst" ] ], "additional_components": [ "DDB_G0269144", "DDB_G0269144", "DDB_G0288643" ] }, "reaction_10622877": { "compartment": "compartment_70101", "id": "reaction_10622877", "reactome": "R-DDI-8932413", "name": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583736", "species_71284" ], "products": [ "species_10622869", "species_71285" ], "modifiers": [ [ "species_10622874", "catalyst" ] ], "additional_components": [ "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "P0CT32", "DDB_G0269136", "P0CT31", "DDB_G0269134", "DDB_G0278427" ] }, "reaction_10588690": { "compartment": "compartment_70101", "id": "reaction_10588690", "reactome": "R-DDI-209845", "name": "CYP2R1 25-hydroxylates VD3 to 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_8963870", "species_29364" ], "products": [ "species_8963879", "species_29356", "species_29366" ], "modifiers": [ [ "species_10588687", "catalyst" ] ], "additional_components": [ "DDB_G0284535" ] }, "reaction_10586707": { "compartment": "compartment_70101", "id": "reaction_10586707", "reactome": "R-DDI-193800", "name": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193829", "species_29364" ], "products": [ "species_29366", "species_193843" ], "modifiers": [ [ "species_10586594", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586709": { "compartment": "compartment_70101", "id": "reaction_10586709", "reactome": "R-DDI-193816", "name": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_192194" ], "products": [ "species_70106", "species_193835", "species_73473" ], "modifiers": [ [ "species_10586611", "catalyst" ] ], "additional_components": [ "Q54XR1", "DDB_G0281487", "Q54TU9", "DDB_G0281487" ] }, "reaction_10586711": { "compartment": "compartment_70101", "id": "reaction_10586711", "reactome": "R-DDI-193821", "name": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_9617026" ], "products": [ "species_193829", "species_29366" ], "modifiers": [ [ "species_10586581", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586713": { "compartment": "compartment_70101", "id": "reaction_10586713", "reactome": "R-DDI-193824", "name": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193835", "species_29364" ], "products": [ "species_29366", "species_193830" ], "modifiers": [ [ "species_10586581", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586715": { "compartment": "compartment_70101", "id": "reaction_10586715", "reactome": "R-DDI-193841", "name": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193830" ], "products": [ "species_29366", "species_193842" ], "modifiers": [ [ "species_10586594", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586705": { "compartment": "compartment_70101", "id": "reaction_10586705", "reactome": "R-DDI-193789", "name": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192189", "species_29360" ], "products": [ "species_193724", "species_70106", "species_73473" ], "modifiers": [ [ "species_10586611", "catalyst" ] ], "additional_components": [ "Q54XR1", "DDB_G0281487", "Q54TU9", "DDB_G0281487" ] }, "reaction_10586697": { "compartment": "compartment_70101", "id": "reaction_10586697", "reactome": "R-DDI-193746", "name": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193724", "species_70106", "species_29364" ], "products": [ "species_29366", "species_193760" ], "modifiers": [ [ "species_10586581", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586699": { "compartment": "compartment_70101", "id": "reaction_10586699", "reactome": "R-DDI-193755", "name": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193745" ], "products": [ "species_193707", "species_29366" ], "modifiers": [ [ "species_10586581", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586701": { "compartment": "compartment_70101", "id": "reaction_10586701", "reactome": "R-DDI-193758", "name": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193760" ], "products": [ "species_29366", "species_213285" ], "modifiers": [ [ "species_10586594", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586703": { "compartment": "compartment_70101", "id": "reaction_10586703", "reactome": "R-DDI-193781", "name": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193707", "species_29364" ], "products": [ "species_29366", "species_193728" ], "modifiers": [ [ "species_10586594", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586688": { "compartment": "compartment_17951", "id": "reaction_10586688", "reactome": "R-DDI-193369", "name": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_193442" ], "products": [ "species_113575", "species_193459" ], "modifiers": [ [ "species_10586633", "catalyst" ] ], "additional_components": [ "species_113596", "Q54GQ6", "DDB_G0289993" ] }, "reaction_10586691": { "compartment": "compartment_17951", "id": "reaction_10586691", "reactome": "R-DDI-193455", "name": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193422", "species_192307" ], "products": [ "species_193465", "species_192305", "species_192339" ], "modifiers": [ [ "species_10586623", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10586626": { "compartment": "compartment_17951", "id": "reaction_10586626", "reactome": "R-DDI-192331", "name": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_192342" ], "products": [ "species_193422" ], "modifiers": [ [ "species_10586623", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10586597": { "compartment": "compartment_70101", "id": "reaction_10586597", "reactome": "R-DDI-192036", "name": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_192064" ], "products": [ "species_29366", "species_192087" ], "modifiers": [ [ "species_10586594", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586693": { "compartment": "compartment_17951", "id": "reaction_10586693", "reactome": "R-DDI-193508", "name": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193732", "species_192307" ], "products": [ "species_193465", "species_193403", "species_192305" ], "modifiers": [ [ "species_10586623", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10586599": { "compartment": "compartment_70101", "id": "reaction_10586599", "reactome": "R-DDI-192067", "name": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_192195" ], "products": [ "species_29366", "species_192064" ], "modifiers": [ [ "species_10586581", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586695": { "compartment": "compartment_17951", "id": "reaction_10586695", "reactome": "R-DDI-193535", "name": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_193459" ], "products": [ "species_193732" ], "modifiers": [ [ "species_10586623", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10586614": { "compartment": "compartment_70101", "id": "reaction_10586614", "reactome": "R-DDI-192097", "name": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_192114" ], "products": [ "species_70106", "species_192136", "species_73473" ], "modifiers": [ [ "species_10586611", "catalyst" ] ], "additional_components": [ "Q54XR1", "DDB_G0281487", "Q54TU9", "DDB_G0281487" ] }, "reaction_10586584": { "compartment": "compartment_70101", "id": "reaction_10586584", "reactome": "R-DDI-192033", "name": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_192136", "species_29364" ], "products": [ "species_191980", "species_29366" ], "modifiers": [ [ "species_10586581", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586616": { "compartment": "compartment_70101", "id": "reaction_10586616", "reactome": "R-DDI-192160", "name": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191980", "species_70106", "species_29364" ], "products": [ "species_192030", "species_29366" ], "modifiers": [ [ "species_10586594", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10586636": { "compartment": "compartment_17951", "id": "reaction_10586636", "reactome": "R-DDI-192335", "name": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_192316" ], "products": [ "species_113575", "species_192342" ], "modifiers": [ [ "species_10586633", "catalyst" ] ], "additional_components": [ "species_113596", "Q54GQ6", "DDB_G0289993" ] }, "reaction_10586686": { "compartment": "compartment_876", "id": "reaction_10586686", "reactome": "R-DDI-193362", "name": "ABCB11 transports bile salts from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_193416", "species_113592" ], "products": [ "species_29372", "species_29370", "species_193479" ], "modifiers": [ [ "species_10586683", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:36274", "CHEBI:16525", "CHEBI:28865", "CHEBI:17687", "CHEBI:28865", "CHEBI:36274", "CHEBI:9407", "Q54BT3", "DDB_G0293438", "Q8T9W4", "DDB_G0291714" ] }, "reaction_10620155": { "compartment": "compartment_70101", "id": "reaction_10620155", "reactome": "R-DDI-8867667", "name": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8868399" ], "products": [ "species_8868400" ], "modifiers": [ [ "species_10620152", "catalyst" ] ], "additional_components": [ "Q54QP6", "DDB_G0283709", "Q8MPQ7", "DDB_G0280053", "Q86HL8", "DDB_G0274517", "Q54RM1", "DDB_G0283035", "Q54EF5", "DDB_G0291562", "Q86HV4", "DDB_G0276427", "Q55CR2", "DDB_G0269940", "Q55CR3", "DDB_G0269938", "Q54NM4", "DDB_G0285141", "Q86KG4", "DDB_G0272498", "Q54ID7", "DDB_G0288817" ] }, "reaction_10586559": { "compartment": "compartment_70101", "id": "reaction_10586559", "reactome": "R-DDI-191983", "name": "Cholesterol is hydroxylated to 25-hydroxycholesterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176478", "species_70106", "species_29368", "species_29364" ], "products": [ "species_29356", "species_192148", "species_29366" ], "modifiers": [ [ "species_10586556", "catalyst" ] ], "additional_components": [ "species_71067", "Q55D52", "DDB_G0279611", "Q55D54", "DDB_G0279611", "Q54WK0", "DDB_G0279611" ] }, "reaction_10586717": { "compartment": "compartment_70101", "id": "reaction_10586717", "reactome": "R-DDI-193961", "name": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196366" ], "products": [ "species_193092" ], "modifiers": [ [ "species_10586654", "catalyst" ] ], "additional_components": [ "Q54XR1", "DDB_G0281487", "Q54TU9", "DDB_G0281487" ] }, "reaction_10586780": { "compartment": "compartment_70101", "id": "reaction_10586780", "reactome": "R-DDI-196372", "name": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193124", "species_29360" ], "products": [ "species_196366", "species_70106", "species_73473" ], "modifiers": [ [ "species_10586654", "catalyst" ] ], "additional_components": [ "Q54XR1", "DDB_G0281487", "Q54TU9", "DDB_G0281487" ] }, "reaction_10586657": { "compartment": "compartment_70101", "id": "reaction_10586657", "reactome": "R-DDI-193052", "name": "Pregn-5-ene-3,20-dione isomerizes to progesterone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196344" ], "products": [ "species_193055" ], "modifiers": [ [ "species_10586654", "catalyst" ] ], "additional_components": [ "Q54XR1", "DDB_G0281487", "Q54TU9", "DDB_G0281487" ] }, "reaction_10586778": { "compartment": "compartment_70101", "id": "reaction_10586778", "reactome": "R-DDI-196350", "name": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193103", "species_29360" ], "products": [ "species_70106", "species_196344", "species_73473" ], "modifiers": [ [ "species_10586654", "catalyst" ] ], "additional_components": [ "Q54XR1", "DDB_G0281487", "Q54TU9", "DDB_G0281487" ] }, "reaction_10586775": { "compartment": "compartment_70101", "id": "reaction_10586775", "reactome": "R-DDI-196060", "name": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196095", "species_70106", "species_29364" ], "products": [ "species_29366", "species_196066" ], "modifiers": [ [ "species_10586772", "catalyst" ] ], "additional_components": [ "Q55FL3", "DDB_G0268058", "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562" ] }, "reaction_10627409": { "compartment": "compartment_70101", "id": "reaction_10627409", "reactome": "R-DDI-9705714", "name": "SRD5A3 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193057" ], "products": [ "species_469662", "species_29366" ], "modifiers": [ [ "species_10603671", "catalyst" ] ], "additional_components": [ "DDB_G0284423" ] }, "reaction_10586669": { "compartment": "compartment_70101", "id": "reaction_10586669", "reactome": "R-DDI-193064", "name": "HSD17B3-like proteins reducde ANDST to TEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193079", "species_29364" ], "products": [ "species_29366", "species_193057" ], "modifiers": [ [ "species_10586666", "catalyst" ] ], "additional_components": [ "Q869Y3", "DDB_G0275049" ] }, "reaction_10586671": { "compartment": "compartment_70101", "id": "reaction_10586671", "reactome": "R-DDI-193073", "name": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176626", "species_29360" ], "products": [ "species_70106", "species_193079", "species_73473" ], "modifiers": [ [ "species_10586654", "catalyst" ] ], "additional_components": [ "Q54XR1", "DDB_G0281487", "Q54TU9", "DDB_G0281487" ] }, "reaction_10594144": { "compartment": "compartment_70101", "id": "reaction_10594144", "reactome": "R-DDI-804969", "name": "HSD17B1 hydrogenates E1 to EST17b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193066", "species_29364" ], "products": [ "species_193132", "species_29366" ], "modifiers": [ [ "species_10594141", "catalyst" ] ], "additional_components": [ "Q556S5", "DDB_G0273855" ] }, "reaction_10612176": { "compartment": "compartment_5460", "id": "reaction_10612176", "reactome": "R-DDI-5696822", "name": "AKR1B15 reduces EST17b to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_5696835" ], "products": [ "species_113529", "species_5696848", "species_113600" ], "modifiers": [ [ "species_10612173", "catalyst" ] ], "additional_components": [ "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058", "Q6IMN8", "DDB_G0293850" ] }, "reaction_10586465": { "compartment": "compartment_70101", "id": "reaction_10586465", "reactome": "R-DDI-191402", "name": "Reduction of presqualene diphosphate to form squalene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_191265" ], "products": [ "species_111294", "species_191269", "species_29366" ], "modifiers": [ [ "species_10586462", "catalyst" ] ], "additional_components": [ "species_29926", "Q54DR1", "DDB_G0292072" ] }, "reaction_10586752": { "compartment": "compartment_70101", "id": "reaction_10586752", "reactome": "R-DDI-194718", "name": "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194657", "species_29360" ], "products": [ "species_70106", "species_113528", "species_194661", "species_73473" ], "modifiers": [ [ "species_10586724", "catalyst" ] ], "additional_components": [ "DDB_G0281487" ] }, "reaction_10586467": { "compartment": "compartment_70101", "id": "reaction_10586467", "reactome": "R-DDI-191405", "name": "Two FPP molecules dimerize to form presqualene diphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191385" ], "products": [ "species_111294", "species_191265" ], "modifiers": [ [ "species_10586462", "catalyst" ] ], "additional_components": [ "species_29926", "Q54DR1", "DDB_G0292072" ] }, "reaction_10586435": { "compartment": "compartment_70101", "id": "reaction_10586435", "reactome": "R-DDI-191366", "name": "Squalene 2,3-epoxide cyclizes, forming lanosterol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191309" ], "products": [ "species_194634" ], "modifiers": [ [ "species_10586432", "catalyst" ] ], "additional_components": [ "DDB_G0269226" ] }, "reaction_10586722": { "compartment": "compartment_70101", "id": "reaction_10586722", "reactome": "R-DDI-194641", "name": "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_194644", "species_29364" ], "products": [ "species_194735", "species_29356", "species_29366" ], "modifiers": [ [ "species_10586719", "catalyst" ] ], "additional_components": [ "DDB_G0279611" ] }, "reaction_10586727": { "compartment": "compartment_70101", "id": "reaction_10586727", "reactome": "R-DDI-194642", "name": "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194735", "species_29360" ], "products": [ "species_70106", "species_113528", "species_194667", "species_73473" ], "modifiers": [ [ "species_10586724", "catalyst" ] ], "additional_components": [ "DDB_G0281487" ] }, "reaction_10586409": { "compartment": "compartment_70101", "id": "reaction_10586409", "reactome": "R-DDI-191303", "name": "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191409", "species_191362" ], "products": [ "species_111294", "species_191385" ], "modifiers": [ [ "species_10586406", "catalyst" ] ], "additional_components": [ "Q54BK1", "DDB_G0293588", "species_29926", "Q9NH03", "DDB_G0278735" ] }, "reaction_10586729": { "compartment": "compartment_70101", "id": "reaction_10586729", "reactome": "R-DDI-194669", "name": "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_194723" ], "products": [ "species_29356", "species_29366", "species_194657" ], "modifiers": [ [ "species_10586719", "catalyst" ] ], "additional_components": [ "DDB_G0279611" ] }, "reaction_10586445": { "compartment": "compartment_70101", "id": "reaction_10586445", "reactome": "R-DDI-191380", "name": "Mevalonate is phosphorylated to mevalonate-5-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191424" ], "products": [ "species_29370", "species_191296" ], "modifiers": [ [ "species_10586442", "catalyst" ] ], "additional_components": [ "Q86AG7", "DDB_G0272018" ] }, "reaction_10586477": { "compartment": "compartment_70101", "id": "reaction_10586477", "reactome": "R-DDI-191414", "name": "MVD decarboxylates MVA5PP to IPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191403" ], "products": [ "species_29372", "species_29370", "species_113528", "species_191362" ], "modifiers": [ [ "species_10586474", "catalyst" ] ], "additional_components": [ "Q54YQ9", "DDB_G0278607" ] }, "reaction_10586412": { "compartment": "compartment_70101", "id": "reaction_10586412", "reactome": "R-DDI-191322", "name": "Addition of isopentenyl pyrophosphate to DMAPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191324", "species_191362" ], "products": [ "species_111294", "species_191409" ], "modifiers": [ [ "species_10586406", "catalyst" ] ], "additional_components": [ "Q54BK1", "DDB_G0293588", "species_29926", "Q9NH03", "DDB_G0278735" ] }, "reaction_10623693": { "compartment": "compartment_70101", "id": "reaction_10623693", "reactome": "R-DDI-8952137", "name": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_191265" ], "products": [ "species_8952135", "species_29372" ], "modifiers": [ [ "species_10623690", "catalyst" ] ], "additional_components": [ "DDB_G0281069" ] }, "reaction_10586417": { "compartment": "compartment_70101", "id": "reaction_10586417", "reactome": "R-DDI-191323", "name": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191293", "species_76183" ], "products": [ "species_29356", "species_191374", "species_76194" ], "modifiers": [ [ "species_10586414", "catalyst" ] ], "additional_components": [ "DDB_G0274871" ] }, "reaction_10586737": { "compartment": "compartment_13231", "id": "reaction_10586737", "reactome": "R-DDI-194674", "name": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194681", "species_194725", "species_194688" ], "products": [ "species_194668", "species_194704" ], "modifiers": [ [ "species_10586734", "catalyst" ] ], "additional_components": [ "DDB_G0267448" ] }, "reaction_10586386": { "compartment": "compartment_70101", "id": "reaction_10586386", "reactome": "R-DDI-191299", "name": "Squalene is oxidized to its epoxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_191269", "species_29364" ], "products": [ "species_191309", "species_29356", "species_29366" ], "modifiers": [ [ "species_10586383", "catalyst" ] ], "additional_components": [ "species_113596", "Q54BK7", "DDB_G0293584" ] }, "reaction_10586455": { "compartment": "compartment_70101", "id": "reaction_10586455", "reactome": "R-DDI-191382", "name": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362" ], "products": [ "species_191324" ], "modifiers": [ [ "species_10586452", "catalyst" ] ], "additional_components": [ "Q9NH02", "DDB_G0290011", "species_29926" ] }, "reaction_10586745": { "compartment": "compartment_70101", "id": "reaction_10586745", "reactome": "R-DDI-194678", "name": "CYP51A1 demethylates LNSOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_194634", "species_29364" ], "products": [ "species_29356", "species_29366", "species_194644", "species_29460" ], "modifiers": [ [ "species_10586742", "catalyst" ] ], "additional_components": [ "DDB_G0279403" ] }, "reaction_10586427": { "compartment": "compartment_70101", "id": "reaction_10586427", "reactome": "R-DDI-191352", "name": "HMGCR dimer reduces bHMG-CoA to MVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191374", "species_70106", "species_29364" ], "products": [ "species_29366", "species_76194", "species_191424" ], "modifiers": [ [ "species_10586424", "catalyst" ] ], "additional_components": [ "P34135", "DDB_G0269142" ] }, "reaction_10616679": { "compartment": "compartment_12045", "id": "reaction_10616679", "reactome": "R-DDI-6807052", "name": "EBP isomerizes ZYMSTNL to LTHSOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6807048" ], "products": [ "species_6807054" ], "modifiers": [ [ "species_10586757", "catalyst" ] ], "additional_components": [ "DDB_G0269414" ] }, "reaction_10616681": { "compartment": "compartment_12045", "id": "reaction_10616681", "reactome": "R-DDI-6807055", "name": "DHCR7 reduces 7-dehydroCHOL to CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_6807057", "species_29364" ], "products": [ "species_193384", "species_29366" ], "modifiers": [ [ "species_10586785", "catalyst" ] ], "additional_components": [ "DDB_G0284407" ] }, "reaction_10604925": { "compartment": "compartment_17957", "id": "reaction_10604925", "reactome": "R-DDI-5250531", "name": "ARV1 transports CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193384" ], "products": [ "species_171095" ], "modifiers": [ [ "species_10604922", "catalyst" ] ], "additional_components": [ "DDB_G0290221" ] }, "reaction_10586750": { "compartment": "compartment_70101", "id": "reaction_10586750", "reactome": "R-DDI-194698", "name": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_194644", "species_29364" ], "products": [ "species_194633", "species_29366" ], "modifiers": [ [ "species_10586747", "catalyst" ] ], "additional_components": [ "DDB_G0267448" ] }, "reaction_10580109": { "compartment": "compartment_70101", "id": "reaction_10580109", "reactome": "R-DDI-72670", "name": "Formation of eIF2:GDP:eIF2B intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580105", "species_10580049" ], "products": [ "species_10580107" ], "modifiers": [], "additional_components": [ "Q54I81", "DDB_G0288961", "Q54RF3", "DDB_G0283163", "Q54FQ8", "DDB_G0290693", "Q54EY2", "DDB_G0291271", "Q54FM3", "DDB_G0290759", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29420", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "Q54I81", "DDB_G0288961", "Q54RF3", "DDB_G0283163", "Q54FQ8", "DDB_G0290693", "Q54EY2", "DDB_G0291271", "Q54FM3", "DDB_G0290759", "species_29420" ] }, "reaction_10580399": { "compartment": "compartment_70101", "id": "reaction_10580399", "reactome": "R-DDI-72722", "name": "eIF2 activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10580107" ], "products": [ "species_29420", "species_10580105", "species_10580004" ], "modifiers": [ [ "species_10580105", "catalyst" ] ], "additional_components": [ "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "Q54I81", "DDB_G0288961", "Q54RF3", "DDB_G0283163", "Q54FQ8", "DDB_G0290693", "Q54EY2", "DDB_G0291271", "Q54FM3", "DDB_G0290759", "species_29420", "Q54I81", "DDB_G0288961", "Q54RF3", "DDB_G0283163", "Q54FQ8", "DDB_G0290693", "Q54EY2", "DDB_G0291271", "Q54FM3", "DDB_G0290759", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54I81", "DDB_G0288961", "Q54RF3", "DDB_G0283163", "Q54FQ8", "DDB_G0290693", "Q54EY2", "DDB_G0291271", "Q54FM3", "DDB_G0290759" ] }, "reaction_10616599": { "compartment": "compartment_7660", "id": "reaction_10616599", "reactome": "R-DDI-6805061", "name": "CK2 binds FACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583211", "species_10616595" ], "products": [ "species_10616597" ], "modifiers": [], "additional_components": [ "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q54PF1", "DDB_G0284601", "Q02720", "DDB_G0276885", "Q54LR6", "DDB_G0286481", "Q54PF1", "DDB_G0284601", "Q02720", "DDB_G0276885", "Q54LR6", "DDB_G0286481", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677" ] }, "reaction_10603956": { "compartment": "compartment_7660", "id": "reaction_10603956", "reactome": "R-DDI-4570489", "name": "SUMOylation of NOP58 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601786", "species_10603928" ], "products": [ "species_10601725", "species_10603953" ], "modifiers": [ [ "species_10601786", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q54SX2", "DDB_G0282161", "DDB_G0268098", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "DDB_G0268098", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q54SX2", "DDB_G0282161" ] }, "reaction_10603944": { "compartment": "compartment_7660", "id": "reaction_10603944", "reactome": "R-DDI-4570467", "name": "SUMOylation of NOP58 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10603928" ], "products": [ "species_10601725", "species_10603942" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0268098", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q55FI4", "DDB_G0268098", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10583553": { "compartment": "compartment_114521", "id": "reaction_10583553", "reactome": "R-DDI-139854", "name": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_139827" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10583550", "catalyst" ] ], "additional_components": [ "species_114520", "species_74112", "Q9NA13", "DDB_G0292564" ] }, "reaction_10598400": { "compartment": "compartment_161320", "id": "reaction_10598400", "reactome": "R-DDI-1605736", "name": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605716", "species_1605715" ], "products": [ "species_1605637", "species_1605601" ], "modifiers": [ [ "species_10598397", "catalyst" ] ], "additional_components": [ "Q54EG4", "DDB_G0291524", "Q55B10", "DDB_G0271490" ] }, "reaction_10598437": { "compartment": "compartment_876", "id": "reaction_10598437", "reactome": "R-DDI-1606583", "name": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429807" ], "products": [ "species_1606609", "species_1861754" ], "modifiers": [ [ "species_10598434", "catalyst" ] ], "additional_components": [] }, "reaction_10598343": { "compartment": "compartment_161320", "id": "reaction_10598343", "reactome": "R-DDI-1605624", "name": "Beta-galactosidase hydrolyses GM1 to GM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605677" ], "products": [ "species_1605637", "species_1605610" ], "modifiers": [ [ "species_10598338", "catalyst" ] ], "additional_components": [ "DDB_G0290217" ] }, "reaction_10598425": { "compartment": "compartment_876", "id": "reaction_10598425", "reactome": "R-DDI-1606273", "name": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429776" ], "products": [ "species_429807", "species_1610735" ], "modifiers": [ [ "species_10598422", "catalyst" ] ], "additional_components": [ "Q86IG2", "DDB_G0288017", "Q1ZXD9", "DDB_G0288017", "species_29926" ] }, "reaction_10598408": { "compartment": "compartment_161320", "id": "reaction_10598408", "reactome": "R-DDI-1605797", "name": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605713" ], "products": [ "species_1605750", "species_1605673" ], "modifiers": [ [ "species_10598405", "catalyst" ] ], "additional_components": [ "DDB_G0293210" ] }, "reaction_10598427": { "compartment": "compartment_161320", "id": "reaction_10598427", "reactome": "R-DDI-1606312", "name": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605601" ], "products": [ "species_1605637", "species_1605592" ], "modifiers": [ [ "species_10598338", "catalyst" ] ], "additional_components": [ "DDB_G0290217" ] }, "reaction_10599629": { "compartment": "compartment_876", "id": "reaction_10599629", "reactome": "R-DDI-1861788", "name": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1861782" ], "products": [ "species_429807", "species_70113" ], "modifiers": [ [ "species_10599626", "catalyst" ] ], "additional_components": [ "DDB_G0292446" ] }, "reaction_10598508": { "compartment": "compartment_876", "id": "reaction_10598508", "reactome": "R-DDI-1640164", "name": "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429776" ], "products": [ "species_429807", "species_1610735" ], "modifiers": [ [ "species_10598505", "catalyst" ] ], "additional_components": [ "DDB_G0285897" ] }, "reaction_10598383": { "compartment": "compartment_161320", "id": "reaction_10598383", "reactome": "R-DDI-1605632", "name": "Both hexosaminidase A and B can cleave GalNAc from globoside", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605608" ], "products": [ "species_1605716", "species_1605658" ], "modifiers": [ [ "species_10598380", "catalyst" ] ], "additional_components": [ "Q54K55", "DDB_G0287597", "Q54SC9", "DDB_G0282539", "Q54K56", "DDB_G0287659", "Q54MU9", "DDB_G0285647", "P13723", "DDB_G0287033" ] }, "reaction_10605541": { "compartment": "compartment_876", "id": "reaction_10605541", "reactome": "R-DDI-5617178", "name": "ATP2B4 binds to NOS1, inhibiting it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590744", "species_10590737" ], "products": [ "species_10605539" ], "modifiers": [], "additional_components": [ "DDB_G0269912", "P54678", "DDB_G0277861", "Q54HG6", "DDB_G0289473", "Q54PE8", "DDB_G0289473", "P54678", "DDB_G0277861", "Q54HG6", "DDB_G0289473", "Q54PE8", "DDB_G0289473", "Q55CT1", "DDB_G0269912" ] }, "reaction_10595189": { "compartment": "compartment_876", "id": "reaction_10595189", "reactome": "R-DDI-936942", "name": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10595116", "species_10577037" ], "products": [ "species_10595186" ], "modifiers": [ [ "species_10595116", "catalyst" ] ], "additional_components": [ "Q54F79", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55A66", "DDB_G0293202", "P11467", "DDB_G0290961", "Q55GA0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54FD5", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "P11467", "DDB_G0290961", "Q86L54", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "Q54F79", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55A66", "DDB_G0293202", "P11467", "DDB_G0290961", "Q55GA0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54LU8", "DDB_G0286465" ] }, "reaction_10595191": { "compartment": "compartment_70101", "id": "reaction_10595191", "reactome": "R-DDI-936963", "name": "IRAK2 induces TRAF6 oligomerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10595114", "species_10584497" ], "products": [ "species_10595116" ], "modifiers": [], "additional_components": [ "Q54F79", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55A66", "DDB_G0293202", "P11467", "DDB_G0290961", "Q55GA0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55A66", "DDB_G0293202", "P11467", "DDB_G0290961", "Q55GA0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54LU8", "DDB_G0286465" ] }, "reaction_10595194": { "compartment": "compartment_70101", "id": "reaction_10595194", "reactome": "R-DDI-936986", "name": "Activated TRAF6 synthesizes unanchored polyubiquitin chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037" ], "products": [ "species_10584754" ], "modifiers": [ [ "species_10595186", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54FD5", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "P11467", "DDB_G0290961", "Q86L54", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54LU8", "DDB_G0286465" ] }, "reaction_10595760": { "compartment": "compartment_74700", "id": "reaction_10595760", "reactome": "R-DDI-975147", "name": "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10595757", "species_10577037" ], "products": [ "species_10593152" ], "modifiers": [ [ "species_10595757", "catalyst" ] ], "additional_components": [ "Q55A66", "DDB_G0293202", "P11467", "DDB_G0290961", "Q55GA0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54C11", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "P11467", "DDB_G0290961", "Q86L54", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "Q55A66", "DDB_G0293202", "P11467", "DDB_G0290961", "Q55GA0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q54LU8", "DDB_G0286465" ] }, "reaction_10595762": { "compartment": "compartment_74700", "id": "reaction_10595762", "reactome": "R-DDI-975185", "name": "IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10595755", "species_10584497" ], "products": [ "species_10595757" ], "modifiers": [], "additional_components": [ "Q55A66", "DDB_G0293202", "P11467", "DDB_G0290961", "Q55GA0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q54LU8", "DDB_G0286465", "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q55A66", "DDB_G0293202", "P11467", "DDB_G0290961", "Q55GA0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q54LU8", "DDB_G0286465" ] }, "reaction_10584367": { "compartment": "compartment_984", "id": "reaction_10584367", "reactome": "R-DDI-166015", "name": "Association of LBP with LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584361", "species_166005" ], "products": [ "species_10584363" ], "modifiers": [ [ "species_10584365", "inhibitor" ] ], "additional_components": [ "Q54JE8", "DDB_G0288097", "Q55BA2", "DDB_G0271242", "Q54JE7", "DDB_G0288097", "species_166005", "Q54JE8", "DDB_G0288097", "Q55BA2", "DDB_G0271242", "Q54JE7", "DDB_G0288097", "DDB_G0271242" ] }, "reaction_10616640": { "compartment": "compartment_984", "id": "reaction_10616640", "reactome": "R-DDI-6805981", "name": "HMGB1 release from cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589181" ], "products": [ "species_10616549" ], "modifiers": [], "additional_components": [ "DDB_G0270260", "DDB_G0270260" ] }, "reaction_10616553": { "compartment": "compartment_984", "id": "reaction_10616553", "reactome": "R-DDI-6804099", "name": "HMGB1 binds LTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_181015", "species_10616549" ], "products": [ "species_10616551" ], "modifiers": [], "additional_components": [ "DDB_G0270260", "Q55C24", "DDB_G0270260", "species_181015" ] }, "reaction_10620682": { "compartment": "compartment_984", "id": "reaction_10620682", "reactome": "R-DDI-8869683", "name": "oxPL binds LBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584361", "species_2186967" ], "products": [ "species_10620680" ], "modifiers": [], "additional_components": [ "Q54JE8", "DDB_G0288097", "Q55BA2", "DDB_G0271242", "Q54JE7", "DDB_G0288097", "species_2186967", "Q54JE8", "DDB_G0288097", "Q55BA2", "DDB_G0271242", "Q54JE7", "DDB_G0288097" ] }, "reaction_10616557": { "compartment": "compartment_984", "id": "reaction_10616557", "reactome": "R-DDI-6804100", "name": "HMGB1 binds LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_166005", "species_10616549" ], "products": [ "species_10616555" ], "modifiers": [], "additional_components": [ "DDB_G0270260", "Q55C24", "DDB_G0270260", "species_166005" ] }, "reaction_10625430": { "compartment": "compartment_17906", "id": "reaction_10625430", "reactome": "R-DDI-9018815", "name": "RHOT1 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625411", "species_10625426" ], "products": [ "species_10625428" ], "modifiers": [], "additional_components": [ "Q55G45", "DDB_G0267830", "species_29438", "Q9U1M8", "DDB_G0274455", "P54696", "DDB_G0289447", "Q9TW28", "DDB_G0292262", "P54697", "DDB_G0272112", "Q9U1M8", "DDB_G0274455", "P54696", "DDB_G0289447", "Q9TW28", "DDB_G0292262", "P54697", "DDB_G0272112", "Q55G45", "DDB_G0267830", "species_29438" ] }, "reaction_10625416": { "compartment": "compartment_70101", "id": "reaction_10625416", "reactome": "R-DDI-9018814", "name": "RHOT1 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10625411" ], "products": [ "species_29372", "species_10625413" ], "modifiers": [ [ "species_10625411", "catalyst" ] ], "additional_components": [ "Q55G45", "DDB_G0267830", "species_29438", "Q55G45", "DDB_G0267830", "species_29420", "Q55G45", "DDB_G0267830", "species_29438" ] }, "reaction_10607623": { "compartment": "compartment_70101", "id": "reaction_10607623", "reactome": "R-DDI-5676966", "name": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5687536", "species_71284" ], "products": [ "species_5687529", "species_71285" ], "modifiers": [ [ "species_10607620", "catalyst" ] ], "additional_components": [ "DDB_G0280979" ] }, "reaction_10627360": { "compartment": "compartment_7660", "id": "reaction_10627360", "reactome": "R-DDI-9686969", "name": "APC/C:Cdh1 polyubiquitinates SKP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627357", "species_10576865" ], "products": [ "species_10585955" ], "modifiers": [ [ "species_10627357", "catalyst" ] ], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "Q54FX2", "DDB_G0290551", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "Q54FX2", "DDB_G0290551", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "Q54FX2", "DDB_G0290551" ] }, "reaction_10585442": { "compartment": "compartment_70101", "id": "reaction_10585442", "reactome": "R-DDI-174195", "name": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585356", "species_10577037" ], "products": [ "species_10585371" ], "modifiers": [ [ "species_10585356", "catalyst" ] ], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54KM3", "DDB_G0287259", "Q86HN7", "DDB_G0274503", "Q54WX4", "DDB_G0279343", "Q54MZ3", "DDB_G0285601", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54KM3", "DDB_G0287259", "Q86HN7", "DDB_G0274503", "Q54WX4", "DDB_G0279343", "Q54MZ3", "DDB_G0285601", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54KM3", "DDB_G0287259", "Q86HN7", "DDB_G0274503", "Q54WX4", "DDB_G0279343", "Q54MZ3", "DDB_G0285601" ] }, "reaction_10585957": { "compartment": "compartment_7660", "id": "reaction_10585957", "reactome": "R-DDI-188191", "name": "APC/C:Cdh1-mediated degradation of Skp2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585955" ], "products": [ "species_10577547", "species_10585336", "species_10576865" ], "modifiers": [ [ "species_10585327", "catalyst" ] ], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "Q54FX2", "DDB_G0290551", "DDB_G0290551", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q27563", "DDB_G0267408", "P02889", "DDB_G0272564", "P34119", "DDB_G0280969", "Q552Y8", "DDB_G0275753", "Q55G04", "DDB_G0268538", "Q967U1", "DDB_G0285099", "Q54XM7", "DDB_G0278847", "P34120", "DDB_G0272831", "Q86A21", "DDB_G0272969", "Q54S82", "DDB_G0282617", "Q54QR2", "DDB_G0283679", "Q55DY7", "DDB_G0269472", "Q55D66", "DDB_G0269772", "Q556Q0", "DDB_G0273163", "Q54BC8", "DDB_G0293784", "Q55GJ6", "DDB_G0267390", "Q55BV5", "DDB_G0270784", "Q86JA1", "DDB_G0276917", "Q54PN7", "DDB_G0284415", "P34123", "DDB_G0289003", "P34124", "DDB_G0292382", "Q54PJ1", "DDB_G0284517", "Q54JM5", "DDB_G0287953", "Q54HW1", "DDB_G0289189", "Q54UB5", "DDB_G0281315", "Q54UJ0", "DDB_G0281051", "Q54NQ0", "DDB_G0285105", "Q54BC6", "DDB_G0293752", "Q1ZXD3", "DDB_G0288621", "Q553E0", "DDB_G0275775", "Q86IJ1", "DDB_G0272566", "Q559F4", "DDB_G0272951", "Q27562", "DDB_G0282363", "Q55C75", "DDB_G0270188", "Q54DM7", "DDB_G0292122", "Q54WI8", "DDB_G0279633" ] }, "reaction_10585373": { "compartment": "compartment_70101", "id": "reaction_10585373", "reactome": "R-DDI-174105", "name": "Degradation of multiubiquitinated cell cycle proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585371" ], "products": [ "species_10577037", "species_10577384" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54KM3", "DDB_G0287259", "Q86HN7", "DDB_G0274503", "Q54WX4", "DDB_G0279343", "Q54MZ3", "DDB_G0285601", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54KM3", "DDB_G0287259", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10585358": { "compartment": "compartment_70101", "id": "reaction_10585358", "reactome": "R-DDI-174088", "name": "Association of cell cycle proteins with the APC/C:Cdh1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585354", "species_10577384" ], "products": [ "species_10585356" ], "modifiers": [], "additional_components": [ "Q86HN7", "DDB_G0274503", "Q54XS6", "DDB_G0278775", "Q54WX4", "DDB_G0279343", "Q54MZ3", "DDB_G0285601", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54KM3", "DDB_G0287259", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54KM3", "DDB_G0287259", "Q86HN7", "DDB_G0274503", "Q54WX4", "DDB_G0279343", "Q54MZ3", "DDB_G0285601" ] }, "reaction_10585448": { "compartment": "compartment_70101", "id": "reaction_10585448", "reactome": "R-DDI-174203", "name": "SCF-mediated degradation of Emi1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585434" ], "products": [ "species_10577037", "species_10585446", "species_10585428" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q7KWS8", "DDB_G0276283", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54KM3", "DDB_G0287259", "Q54MZ3", "DDB_G0285601", "Q7KWS8", "DDB_G0276283", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10585437": { "compartment": "compartment_70101", "id": "reaction_10585437", "reactome": "R-DDI-174159", "name": "Ubiquitination of Emi1 by SCF-beta-TrCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10585432" ], "products": [ "species_10585434" ], "modifiers": [ [ "species_10585428", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q7KWS8", "DDB_G0276283", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q7KWS8", "DDB_G0276283", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q7KWS8", "DDB_G0276283", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972" ] }, "reaction_10585961": { "compartment": "compartment_7660", "id": "reaction_10585961", "reactome": "R-DDI-188371", "name": "Association of Cyclin A:Cdk2 with Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585336", "species_10576705" ], "products": [ "species_10585338" ], "modifiers": [], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "P34112", "DDB_G0272813", "P34112", "DDB_G0272813", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259" ] }, "reaction_10583654": { "compartment": "compartment_70101", "id": "reaction_10583654", "reactome": "R-DDI-141423", "name": "Binding of the MCC complex to the APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583650", "species_10577377" ], "products": [ "species_10583652" ], "modifiers": [], "additional_components": [ "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601" ] }, "reaction_10583660": { "compartment": "compartment_70101", "id": "reaction_10583660", "reactome": "R-DDI-141437", "name": "Formation of the MCC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583643", "species_10583638", "species_10583648", "species_10583633" ], "products": [ "species_10583650" ], "modifiers": [], "additional_components": [ "DDB_G0285601", "DDB_G0292134", "DDB_G0273201", "DDB_G0292676", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601" ] }, "reaction_10583658": { "compartment": "compartment_70101", "id": "reaction_10583658", "reactome": "R-DDI-141429", "name": "Inactivation of APC/C via CDC20 sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583643", "species_10583648" ], "products": [ "species_10583656" ], "modifiers": [], "additional_components": [ "DDB_G0285601", "DDB_G0273201", "Q556Y9", "DDB_G0273201", "Q54MZ3", "DDB_G0285601" ] }, "reaction_10585343": { "compartment": "compartment_7660", "id": "reaction_10585343", "reactome": "R-DDI-174079", "name": "Phosphorylation of Cdh1 by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10585338" ], "products": [ "species_113582", "species_10585340" ], "modifiers": [ [ "species_10585338", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "P34112", "DDB_G0272813", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "P34112", "DDB_G0272813", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259" ] }, "reaction_10585390": { "compartment": "compartment_7660", "id": "reaction_10585390", "reactome": "R-DDI-174139", "name": "Dissociation of phospho-Cdh1 from the APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585236" ], "products": [ "species_10585192", "species_10585234" ], "modifiers": [], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "DDB_G0287259", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230" ] }, "reaction_10585458": { "compartment": "compartment_70101", "id": "reaction_10585458", "reactome": "R-DDI-174238", "name": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583652" ], "products": [ "species_10585386", "species_10585456" ], "modifiers": [], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54MZ3", "DDB_G0285601", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134" ] }, "reaction_10585452": { "compartment": "compartment_70101", "id": "reaction_10585452", "reactome": "R-DDI-174227", "name": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10585411" ], "products": [ "species_10585413" ], "modifiers": [ [ "species_10585386", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54MZ3", "DDB_G0285601", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54MZ3", "DDB_G0285601", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54MZ3", "DDB_G0285601" ] }, "reaction_10585369": { "compartment": "compartment_70101", "id": "reaction_10585369", "reactome": "R-DDI-174104", "name": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10585364" ], "products": [ "species_10585366" ], "modifiers": [ [ "species_10583652", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601" ] }, "reaction_10585888": { "compartment": "compartment_70101", "id": "reaction_10585888", "reactome": "R-DDI-179417", "name": "Multiubiquitination of Nek2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10585881" ], "products": [ "species_10585885" ], "modifiers": [ [ "species_10585881", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601", "Q55BN8", "DDB_G0270814", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601", "Q55BN8", "DDB_G0270814", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601", "Q55BN8", "DDB_G0270814" ] }, "reaction_10585890": { "compartment": "compartment_70101", "id": "reaction_10585890", "reactome": "R-DDI-179421", "name": "Degradation of multiubiquitinated Nek2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585885" ], "products": [ "species_10577037", "species_10583652" ], "modifiers": [], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601", "Q55BN8", "DDB_G0270814", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601" ] }, "reaction_10585883": { "compartment": "compartment_70101", "id": "reaction_10585883", "reactome": "R-DDI-179410", "name": "Association of Nek2A with MCC:APC/C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585879", "species_10583652" ], "products": [ "species_10585881" ], "modifiers": [], "additional_components": [ "DDB_G0270814", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54CV5", "DDB_G0292676", "Q556Y9", "DDB_G0273201", "Q54DM1", "DDB_G0292134", "Q54MZ3", "DDB_G0285601", "Q55BN8", "DDB_G0270814" ] }, "reaction_10585444": { "compartment": "compartment_70101", "id": "reaction_10585444", "reactome": "R-DDI-174202", "name": "Degradation of multiubiquitinated Securin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585398" ], "products": [ "species_10577037", "species_10585386" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54MZ3", "DDB_G0285601", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54MZ3", "DDB_G0285601", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10585401": { "compartment": "compartment_70101", "id": "reaction_10585401", "reactome": "R-DDI-174144", "name": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10585394" ], "products": [ "species_10585398" ], "modifiers": [ [ "species_10585386", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54MZ3", "DDB_G0285601", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54MZ3", "DDB_G0285601", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54MZ3", "DDB_G0285601" ] }, "reaction_10585384": { "compartment": "compartment_7660", "id": "reaction_10585384", "reactome": "R-DDI-174119", "name": "Free APC/C phosphorylated by Plk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585234" ], "products": [ "species_10585234" ], "modifiers": [ [ "species_10583697", "catalyst" ] ], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "DDB_G0274503" ] }, "reaction_10585330": { "compartment": "compartment_7660", "id": "reaction_10585330", "reactome": "R-DDI-174058", "name": "Degradation of multiubiquitinated Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585238" ], "products": [ "species_10585234", "species_10576865" ], "modifiers": [ [ "species_10585327", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q27563", "DDB_G0267408", "P02889", "DDB_G0272564", "P34119", "DDB_G0280969", "Q552Y8", "DDB_G0275753", "Q55G04", "DDB_G0268538", "Q967U1", "DDB_G0285099", "Q54XM7", "DDB_G0278847", "P34120", "DDB_G0272831", "Q86A21", "DDB_G0272969", "Q54S82", "DDB_G0282617", "Q54QR2", "DDB_G0283679", "Q55DY7", "DDB_G0269472", "Q55D66", "DDB_G0269772", "Q556Q0", "DDB_G0273163", "Q54BC8", "DDB_G0293784", "Q55GJ6", "DDB_G0267390", "Q55BV5", "DDB_G0270784", "Q86JA1", "DDB_G0276917", "Q54PN7", "DDB_G0284415", "P34123", "DDB_G0289003", "P34124", "DDB_G0292382", "Q54PJ1", "DDB_G0284517", "Q54JM5", "DDB_G0287953", "Q54HW1", "DDB_G0289189", "Q54UB5", "DDB_G0281315", "Q54UJ0", "DDB_G0281051", "Q54NQ0", "DDB_G0285105", "Q54BC6", "DDB_G0293752", "Q1ZXD3", "DDB_G0288621", "Q553E0", "DDB_G0275775", "Q86IJ1", "DDB_G0272566", "Q559F4", "DDB_G0272951", "Q27562", "DDB_G0282363", "Q55C75", "DDB_G0270188", "Q54DM7", "DDB_G0292122", "Q54WI8", "DDB_G0279633" ] }, "reaction_10585241": { "compartment": "compartment_7660", "id": "reaction_10585241", "reactome": "R-DDI-174057", "name": "Multiubiquitination of APC/C-associated Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585236", "species_10576865" ], "products": [ "species_10585238" ], "modifiers": [ [ "species_10585236", "catalyst" ] ], "additional_components": [ "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259", "Q54XS6", "DDB_G0278775", "Q54TE1", "DDB_G0281833", "Q54NC6", "DDB_G0285349", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54J83", "DDB_G0288223", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54YA9", "DDB_G0278327", "Q86B11", "DDB_G0272775", "Q55ER5", "DDB_G0268992", "Q54L48", "DDB_G0286909", "Q54C30", "DDB_G0293230", "Q54KM3", "DDB_G0287259" ] }, "reaction_10598791": { "compartment": "compartment_172574", "id": "reaction_10598791", "reactome": "R-DDI-1675795", "name": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806198", "species_29356" ], "products": [ "species_29372", "species_1806195" ], "modifiers": [ [ "species_10598788", "catalyst" ] ], "additional_components": [ "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250" ] }, "reaction_10599016": { "compartment": "compartment_172574", "id": "reaction_10599016", "reactome": "R-DDI-1676065", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806289" ], "products": [ "species_1806212", "species_29372" ], "modifiers": [ [ "species_10598788", "catalyst" ] ], "additional_components": [ "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250" ] }, "reaction_10599004": { "compartment": "compartment_172574", "id": "reaction_10599004", "reactome": "R-DDI-1676024", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806195" ], "products": [ "species_1806198", "species_29370" ], "modifiers": [ [ "species_10598879", "catalyst" ] ], "additional_components": [ "Q54S78", "DDB_G0282625", "Q55FX5", "DDB_G0282625", "P54673", "DDB_G0278727", "P54674", "DDB_G0283081", "P54675", "DDB_G0275011", "species_74112", "species_29926", "P54676", "DDB_G0289601", "species_266099", "Q54S77", "DDB_G0282627" ] }, "reaction_10599088": { "compartment": "compartment_20699", "id": "reaction_10599088", "reactome": "R-DDI-1676185", "name": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524146" ], "products": [ "species_29370", "species_1806217" ], "modifiers": [ [ "species_10598801", "catalyst" ] ], "additional_components": [ "DDB_G0277537" ] }, "reaction_10599059": { "compartment": "compartment_20699", "id": "reaction_10599059", "reactome": "R-DDI-1676133", "name": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806217" ], "products": [ "species_29372", "species_1524146" ], "modifiers": [ [ "species_10599048", "catalyst" ] ], "additional_components": [ "DDB_G0271630" ] }, "reaction_10598871": { "compartment": "compartment_20699", "id": "reaction_10598871", "reactome": "R-DDI-1675928", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806217" ], "products": [ "species_1806230", "species_29370" ], "modifiers": [ [ "species_10598868", "catalyst" ] ], "additional_components": [ "Q55FX5", "DDB_G0282625", "P54673", "DDB_G0278727", "P54674", "DDB_G0283081", "P54675", "DDB_G0275011", "Q54S78", "DDB_G0282625", "species_74112", "species_29926" ] }, "reaction_10599081": { "compartment": "compartment_20699", "id": "reaction_10599081", "reactome": "R-DDI-1676152", "name": "PI4KB binds to ARF1/3:GTP at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599079", "species_10598835" ], "products": [ "species_10598837" ], "modifiers": [], "additional_components": [ "P54677", "DDB_G0288485", "Q54LR9", "DDB_G0286479", "species_29438", "O00909", "DDB_G0289173", "Q54Y34", "DDB_G0292332", "Q1ZXA5", "DDB_G0292332", "Q54YV7", "DDB_G0278057", "Q54HK2", "DDB_G0289435", "Q55AR1", "DDB_G0271792", "Q54JJ3", "DDB_G0288015", "Q54SH9", "DDB_G0282457", "Q54V41", "DDB_G0280633", "Q54V47", "DDB_G0280621", "Q54VB0", "DDB_G0280479", "P54677", "DDB_G0288485", "Q54LR9", "DDB_G0286479", "species_29438", "O00909", "DDB_G0289173", "Q54Y34", "DDB_G0292332", "Q1ZXA5", "DDB_G0292332", "Q54YV7", "DDB_G0278057", "Q54HK2", "DDB_G0289435", "Q55AR1", "DDB_G0271792", "Q54JJ3", "DDB_G0288015", "Q54SH9", "DDB_G0282457", "Q54V41", "DDB_G0280633", "Q54V47", "DDB_G0280621", "Q54VB0", "DDB_G0280479" ] }, "reaction_10598809": { "compartment": "compartment_20699", "id": "reaction_10598809", "reactome": "R-DDI-1675824", "name": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806165", "species_29356" ], "products": [ "species_29372", "species_1806217" ], "modifiers": [ [ "species_10598806", "catalyst" ] ], "additional_components": [ "DDB_G0267462" ] }, "reaction_10598840": { "compartment": "compartment_20699", "id": "reaction_10598840", "reactome": "R-DDI-1675883", "name": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524146" ], "products": [ "species_29370", "species_1806217" ], "modifiers": [ [ "species_10598837", "catalyst" ] ], "additional_components": [ "P54677", "DDB_G0288485", "Q54LR9", "DDB_G0286479", "species_29438", "O00909", "DDB_G0289173", "Q54Y34", "DDB_G0292332", "Q1ZXA5", "DDB_G0292332", "Q54YV7", "DDB_G0278057", "Q54HK2", "DDB_G0289435", "Q55AR1", "DDB_G0271792", "Q54JJ3", "DDB_G0288015", "Q54SH9", "DDB_G0282457", "Q54V41", "DDB_G0280633", "Q54V47", "DDB_G0280621", "Q54VB0", "DDB_G0280479" ] }, "reaction_10599051": { "compartment": "compartment_20699", "id": "reaction_10599051", "reactome": "R-DDI-1676114", "name": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806159" ], "products": [ "species_29372", "species_1524146" ], "modifiers": [ [ "species_10599048", "catalyst" ] ], "additional_components": [ "DDB_G0271630" ] }, "reaction_10599115": { "compartment": "compartment_20699", "id": "reaction_10599115", "reactome": "R-DDI-1676204", "name": "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806230", "species_29356" ], "products": [ "species_29372", "species_1806217" ], "modifiers": [ [ "species_10599112", "catalyst" ] ], "additional_components": [ "Q54MG8", "DDB_G0285967" ] }, "reaction_10598911": { "compartment": "compartment_20699", "id": "reaction_10598911", "reactome": "R-DDI-1675961", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524146" ], "products": [ "species_29370", "species_1806159" ], "modifiers": [ [ "species_10598879", "catalyst" ] ], "additional_components": [ "Q54S78", "DDB_G0282625", "Q55FX5", "DDB_G0282625", "P54673", "DDB_G0278727", "P54674", "DDB_G0283081", "P54675", "DDB_G0275011", "species_74112", "species_29926", "P54676", "DDB_G0289601", "species_266099", "Q54S77", "DDB_G0282627" ] }, "reaction_10599056": { "compartment": "compartment_12045", "id": "reaction_10599056", "reactome": "R-DDI-1676124", "name": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806234" ], "products": [ "species_29372", "species_426639" ], "modifiers": [ [ "species_10599053", "catalyst" ] ], "additional_components": [ "DDB_G0271630" ] }, "reaction_10598804": { "compartment": "compartment_12045", "id": "reaction_10598804", "reactome": "R-DDI-1675813", "name": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426639" ], "products": [ "species_29370", "species_1806234" ], "modifiers": [ [ "species_10598801", "catalyst" ] ], "additional_components": [ "DDB_G0277537" ] }, "reaction_10617403": { "compartment": "compartment_70101", "id": "reaction_10617403", "reactome": "R-DDI-6809777", "name": "PI3P is dephosphorylated to PI by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5676030" ], "products": [ "species_29372", "species_426639" ], "modifiers": [ [ "species_10617398", "catalyst" ] ], "additional_components": [ "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54TD5", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258" ] }, "reaction_10617400": { "compartment": "compartment_70101", "id": "reaction_10617400", "reactome": "R-DDI-6809764", "name": "SBF1 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598734", "species_10617396" ], "products": [ "species_10617398" ], "modifiers": [], "additional_components": [ "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54TD5", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54TD5", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258" ] }, "reaction_10617406": { "compartment": "compartment_70101", "id": "reaction_10617406", "reactome": "R-DDI-6809778", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6809774" ], "products": [ "species_29372", "species_422529" ], "modifiers": [ [ "species_10617398", "catalyst" ] ], "additional_components": [ "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54TD5", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258" ] }, "reaction_10599073": { "compartment": "compartment_876", "id": "reaction_10599073", "reactome": "R-DDI-1676149", "name": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_202247" ], "products": [ "species_29372", "species_392417" ], "modifiers": [ [ "species_10587224", "catalyst" ] ], "additional_components": [ "DDB_G0286557" ] }, "reaction_10598595": { "compartment": "compartment_876", "id": "reaction_10598595", "reactome": "R-DDI-1675773", "name": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_202247" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10598592", "catalyst" ] ], "additional_components": [ "Q54M96", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635", "Q54VR4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q86D86", "DDB_G0283615", "Q54DL4", "DDB_G0292190" ] }, "reaction_10599043": { "compartment": "compartment_876", "id": "reaction_10599043", "reactome": "R-DDI-1676109", "name": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10599040", "catalyst" ] ], "additional_components": [ "Q54DK0", "DDB_G0292252", "P54675", "DDB_G0275011", "P54673", "DDB_G0278727", "Q54S78", "DDB_G0282625", "Q55FX5", "DDB_G0282625", "P54674", "DDB_G0283081", "species_74112", "species_29926", "species_266099" ] }, "reaction_10617313": { "compartment": "compartment_70101", "id": "reaction_10617313", "reactome": "R-DDI-6809254", "name": "MTMR8 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617309", "species_10617283" ], "products": [ "species_10617311" ], "modifiers": [], "additional_components": [ "Q55AZ2", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54TD5", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54TD5", "DDB_G0293258", "Q54PT8", "DDB_G0293258" ] }, "reaction_10598914": { "compartment": "compartment_876", "id": "reaction_10598914", "reactome": "R-DDI-1675988", "name": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_392417" ], "products": [ "species_29372", "species_426658" ], "modifiers": [ [ "species_10598818", "catalyst" ] ], "additional_components": [ "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392" ] }, "reaction_10599013": { "compartment": "compartment_876", "id": "reaction_10599013", "reactome": "R-DDI-1676048", "name": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10599010", "catalyst" ] ], "additional_components": [ "Q54DK0", "DDB_G0292252", "P54675", "DDB_G0275011", "P54673", "DDB_G0278727", "Q54S78", "DDB_G0282625", "Q55FX5", "DDB_G0282625", "P54674", "DDB_G0283081" ] }, "reaction_10598821": { "compartment": "compartment_876", "id": "reaction_10598821", "reactome": "R-DDI-1675836", "name": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806224" ], "products": [ "species_1806276", "species_29372" ], "modifiers": [ [ "species_10598818", "catalyst" ] ], "additional_components": [ "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392" ] }, "reaction_10598796": { "compartment": "compartment_876", "id": "reaction_10598796", "reactome": "R-DDI-1675810", "name": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426658" ], "products": [ "species_1806240", "species_29370" ], "modifiers": [ [ "species_10598793", "catalyst" ] ], "additional_components": [ "Q54M96", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635", "Q54VR4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q86D86", "DDB_G0283615", "Q54DL4", "DDB_G0292190" ] }, "reaction_10599086": { "compartment": "compartment_876", "id": "reaction_10599086", "reactome": "R-DDI-1676177", "name": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_29372", "species_392417" ], "modifiers": [ [ "species_10599083", "catalyst" ] ], "additional_components": [ "Q54PV1", "DDB_G0284187", "Q54W40", "DDB_G0279927", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392" ] }, "reaction_10617325": { "compartment": "compartment_70101", "id": "reaction_10617325", "reactome": "R-DDI-6809309", "name": "MTMR6 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617309", "species_10598992" ], "products": [ "species_10617323" ], "modifiers": [], "additional_components": [ "Q55AZ2", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54TD5", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258" ] }, "reaction_10617330": { "compartment": "compartment_876", "id": "reaction_10617330", "reactome": "R-DDI-6809320", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806224" ], "products": [ "species_29372", "species_1806240" ], "modifiers": [ [ "species_10617327", "catalyst" ] ], "additional_components": [ "Q54PT8", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258" ] }, "reaction_10599091": { "compartment": "compartment_876", "id": "reaction_10599091", "reactome": "R-DDI-1676203", "name": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806224" ], "products": [ "species_29372", "species_1806240" ], "modifiers": [ [ "species_10598999", "catalyst" ] ], "additional_components": [ "Q54PT8", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54H00", "DDB_G0289807", "Q54D97", "DDB_G0292392" ] }, "reaction_10617333": { "compartment": "compartment_876", "id": "reaction_10617333", "reactome": "R-DDI-6809325", "name": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_29356" ], "products": [ "species_29372", "species_426658" ], "modifiers": [ [ "species_10617327", "catalyst" ] ], "additional_components": [ "Q54PT8", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258" ] }, "reaction_10599062": { "compartment": "compartment_876", "id": "reaction_10599062", "reactome": "R-DDI-1676134", "name": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_113592" ], "products": [ "species_1806224", "species_29370" ], "modifiers": [ [ "species_10598793", "catalyst" ] ], "additional_components": [ "Q54M96", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635", "Q54VR4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q86D86", "DDB_G0283615", "Q54DL4", "DDB_G0292190" ] }, "reaction_10587227": { "compartment": "compartment_70101", "id": "reaction_10587227", "reactome": "R-DDI-199456", "name": "PTEN dephosphorylates PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179838" ], "products": [ "species_29372", "species_179856" ], "modifiers": [ [ "species_10587224", "catalyst" ] ], "additional_components": [ "DDB_G0286557" ] }, "reaction_10599002": { "compartment": "compartment_876", "id": "reaction_10599002", "reactome": "R-DDI-1675994", "name": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_29356" ], "products": [ "species_29372", "species_426658" ], "modifiers": [ [ "species_10598999", "catalyst" ] ], "additional_components": [ "Q54PT8", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54H00", "DDB_G0289807", "Q54D97", "DDB_G0292392" ] }, "reaction_10598909": { "compartment": "compartment_876", "id": "reaction_10598909", "reactome": "R-DDI-1675949", "name": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179838" ], "products": [ "species_29372", "species_202247" ], "modifiers": [ [ "species_10598906", "catalyst" ] ], "additional_components": [ "Q54PV1", "DDB_G0284187", "Q54W40", "DDB_G0279927", "Q8I7P3", "DDB_G0267462" ] }, "reaction_10599070": { "compartment": "compartment_876", "id": "reaction_10599070", "reactome": "R-DDI-1676145", "name": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_113592" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10599067", "catalyst" ] ], "additional_components": [ "Q86D86", "DDB_G0283615", "Q54DL4", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635" ] }, "reaction_10618317": { "compartment": "compartment_876", "id": "reaction_10618317", "reactome": "R-DDI-6814797", "name": "ENPP6 hydrolyzes lysophosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_2239407" ], "products": [ "species_6814794", "species_6814795" ], "modifiers": [ [ "species_10618314", "catalyst" ] ], "additional_components": [ "DDB_G0285897" ] }, "reaction_10598240": { "compartment": "compartment_20699", "id": "reaction_10598240", "reactome": "R-DDI-1483211", "name": "PC:PITPNB is transported from the Golgi membrane to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598146" ], "products": [ "species_10598238" ], "modifiers": [], "additional_components": [ "Q9NCL8", "DDB_G0290069", "species_426925", "species_426925", "Q9NCL8", "DDB_G0290069" ] }, "reaction_10598259": { "compartment": "compartment_12045", "id": "reaction_10598259", "reactome": "R-DDI-1483229", "name": "PI:PITPNB is transported from the ER membrane to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598242" ], "products": [ "species_10598144" ], "modifiers": [], "additional_components": [ "species_426639", "Q9NCL8", "DDB_G0290069", "species_426639", "Q9NCL8", "DDB_G0290069" ] }, "reaction_10598148": { "compartment": "compartment_20699", "id": "reaction_10598148", "reactome": "R-DDI-1483087", "name": "PI is exchanged with PC by PITPNB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429785", "species_10598144" ], "products": [ "species_1524146", "species_10598146" ], "modifiers": [], "additional_components": [ "species_426639", "Q9NCL8", "DDB_G0290069", "Q9NCL8", "DDB_G0290069", "species_426925" ] }, "reaction_10599024": { "compartment": "compartment_171062", "id": "reaction_10599024", "reactome": "R-DDI-1676105", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806205" ], "products": [ "species_29372", "species_1806259" ], "modifiers": [ [ "species_10599021", "catalyst" ] ], "additional_components": [ "Q54C52", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PT8", "DDB_G0293258", "Q55AZ2", "DDB_G0293258" ] }, "reaction_10617363": { "compartment": "compartment_70101", "id": "reaction_10617363", "reactome": "R-DDI-6809680", "name": "MTMR12 binds MTM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617359", "species_10598708" ], "products": [ "species_10617361" ], "modifiers": [], "additional_components": [ "Q54YC2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PT8", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PT8", "DDB_G0293258", "Q55AZ2", "DDB_G0293258" ] }, "reaction_10598882": { "compartment": "compartment_171062", "id": "reaction_10598882", "reactome": "R-DDI-1675939", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806199", "species_113592" ], "products": [ "species_29370", "species_1806200" ], "modifiers": [ [ "species_10598879", "catalyst" ] ], "additional_components": [ "Q54S78", "DDB_G0282625", "Q55FX5", "DDB_G0282625", "P54673", "DDB_G0278727", "P54674", "DDB_G0283081", "P54675", "DDB_G0275011", "species_74112", "species_29926", "P54676", "DDB_G0289601", "species_266099", "Q54S77", "DDB_G0282627" ] }, "reaction_10617367": { "compartment": "compartment_70101", "id": "reaction_10617367", "reactome": "R-DDI-6809707", "name": "MTMR12 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598734", "species_10617359" ], "products": [ "species_10617365" ], "modifiers": [], "additional_components": [ "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258" ] }, "reaction_10618629": { "compartment": "compartment_70101", "id": "reaction_10618629", "reactome": "R-DDI-8849969", "name": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8849959" ], "products": [ "species_29372", "species_8849958" ], "modifiers": [ [ "species_10618626", "catalyst" ] ], "additional_components": [ "species_179838", "species_1806238", "species_179856", "species_1806200", "species_1806205", "species_6810408", "Q86HL0", "DDB_G0290653", "Q55AW9", "DDB_G0271630", "Q54FY6", "DDB_G0290653" ] }, "reaction_10599065": { "compartment": "compartment_171062", "id": "reaction_10599065", "reactome": "R-DDI-1676141", "name": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806200" ], "products": [ "species_29372", "species_1806199" ], "modifiers": [ [ "species_10599021", "catalyst" ] ], "additional_components": [ "Q54C52", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PT8", "DDB_G0293258", "Q55AZ2", "DDB_G0293258" ] }, "reaction_10617370": { "compartment": "compartment_171062", "id": "reaction_10617370", "reactome": "R-DDI-6809720", "name": "PI3P is dephosphorylated to PI by MTM1:MTMR12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806200" ], "products": [ "species_29372", "species_1806199" ], "modifiers": [ [ "species_10617361", "catalyst" ] ], "additional_components": [ "Q54C52", "DDB_G0293258", "Q55BL7", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q54TD5", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q54PL3", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54PT8", "DDB_G0293258", "Q55AZ2", "DDB_G0293258" ] }, "reaction_10599118": { "compartment": "compartment_171062", "id": "reaction_10599118", "reactome": "R-DDI-1676206", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806180", "species_113592" ], "products": [ "species_29370", "species_1806238" ], "modifiers": [ [ "species_10598854", "catalyst" ] ], "additional_components": [ "Q54S78", "DDB_G0282625", "Q55FX5", "DDB_G0282625", "P54673", "DDB_G0278727", "P54674", "DDB_G0283081", "P54675", "DDB_G0275011", "species_74112", "species_29926" ] }, "reaction_10598208": { "compartment": "compartment_12045", "id": "reaction_10598208", "reactome": "R-DDI-1483182", "name": "PC is hydrolyzed to PA and choline by PLD1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_264618", "species_426755" ], "modifiers": [ [ "species_10598205", "catalyst" ] ], "additional_components": [ "Q54WR4", "DDB_G0279483", "Q54Z25", "DDB_G0277949", "Q54Q49", "DDB_G0284155", "Q54UK0", "DDB_G0281031" ] }, "reaction_10612690": { "compartment": "compartment_70101", "id": "reaction_10612690", "reactome": "R-DDI-6786650", "name": "DDHD1,2 hydrolyse PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1602448" ], "products": [ "species_1602447", "species_1602366" ], "modifiers": [ [ "species_10612687", "catalyst" ] ], "additional_components": [ "Q86KP6", "DDB_G0276935", "Q54EA5", "DDB_G0291694", "Q55DN9", "DDB_G0276935", "Q55DP0", "DDB_G0276935" ] }, "reaction_10594009": { "compartment": "compartment_12045", "id": "reaction_10594009", "reactome": "R-DDI-549112", "name": "G3P is acylated to 1-acyl LPA by AGPAT6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_76114" ], "products": [ "species_1500604", "species_76194" ], "modifiers": [ [ "species_10581703", "catalyst" ] ], "additional_components": [ "DDB_G0274969" ] }, "reaction_10623946": { "compartment": "compartment_17906", "id": "reaction_10623946", "reactome": "R-DDI-8954398", "name": "PLD6 dimer hydrolyses cardiolipin to PA and PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189422", "species_8954419" ], "products": [ "species_8954401", "species_1500590" ], "modifiers": [ [ "species_10623943", "catalyst" ] ], "additional_components": [ "Q54TK6", "DDB_G0281695" ] }, "reaction_10585976": { "compartment": "compartment_5460", "id": "reaction_10585976", "reactome": "R-DDI-188467", "name": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_188458" ], "products": [ "species_31649", "species_188451" ], "modifiers": [ [ "species_10585973", "catalyst" ] ], "additional_components": [ "DDB_G0283951" ] }, "reaction_10597949": { "compartment": "compartment_17906", "id": "reaction_10597949", "reactome": "R-DDI-1482548", "name": "1-acyl LPA is acylated to PA by AGPAT5 (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500580" ], "products": [ "species_1500590", "species_76194" ], "modifiers": [ [ "species_10597946", "catalyst" ] ], "additional_components": [ "DDB_G0288523" ] }, "reaction_10622766": { "compartment": "compartment_5460", "id": "reaction_10622766", "reactome": "R-DDI-8878654", "name": "ACP6 hydrolyses MYS-LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8878649", "species_113521" ], "products": [ "species_113548", "species_8934414" ], "modifiers": [ [ "species_10622763", "catalyst" ] ], "additional_components": [ "DDB_G0284363" ] }, "reaction_10581726": { "compartment": "compartment_12045", "id": "reaction_10581726", "reactome": "R-DDI-75885", "name": "1-acyl LPA is acylated to PA by AGPAT (LPAAT)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500604", "species_1500578" ], "products": [ "species_426755", "species_76194" ], "modifiers": [ [ "species_10581723", "catalyst" ] ], "additional_components": [ "Q54IT8", "DDB_G0288523", "Q55CZ2", "DDB_G0288523", "Q54EU4", "DDB_G0291332", "Q554U0", "DDB_G0274969", "Q54X10", "DDB_G0279277", "Q54IG1", "DDB_G0288863" ] }, "reaction_10611940": { "compartment": "compartment_12045", "id": "reaction_10611940", "reactome": "R-DDI-5696448", "name": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696449", "species_6782195" ], "products": [ "species_76194", "species_1500596" ], "modifiers": [ [ "species_10611937", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10598028": { "compartment": "compartment_12045", "id": "reaction_10598028", "reactome": "R-DDI-1482889", "name": "DAG is acylated to TAG by DGAT1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_1500594", "species_76194" ], "modifiers": [ [ "species_10598025", "catalyst" ] ], "additional_components": [ "Q55BH9", "DDB_G0271342", "Q54GC1", "DDB_G0290279" ] }, "reaction_10618492": { "compartment": "compartment_12045", "id": "reaction_10618492", "reactome": "R-DDI-8848580", "name": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_1500594", "species_76194" ], "modifiers": [ [ "species_10618487", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10598017": { "compartment": "compartment_12045", "id": "reaction_10598017", "reactome": "R-DDI-1482861", "name": "MLCL is acylated to CL by LCLAT1 (ER)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1524069" ], "products": [ "species_1524081", "species_76194" ], "modifiers": [ [ "species_10581717", "catalyst" ] ], "additional_components": [ "Q55CZ2", "DDB_G0288523", "Q54IT8", "DDB_G0288523" ] }, "reaction_10598019": { "compartment": "compartment_12045", "id": "reaction_10598019", "reactome": "R-DDI-1482867", "name": "DLCL is acylated to MLCL by LCLAT1 (ER)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524080", "species_1500578" ], "products": [ "species_76194", "species_1524069" ], "modifiers": [ [ "species_10581717", "catalyst" ] ], "additional_components": [ "Q55CZ2", "DDB_G0288523", "Q54IT8", "DDB_G0288523" ] }, "reaction_10597996": { "compartment": "compartment_70616", "id": "reaction_10597996", "reactome": "R-DDI-1482781", "name": "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524075", "species_1498773" ], "products": [ "species_1524072", "species_1524079" ], "modifiers": [ [ "species_10597993", "catalyst" ] ], "additional_components": [ "DDB_G0291922" ] }, "reaction_10598012": { "compartment": "compartment_70616", "id": "reaction_10598012", "reactome": "R-DDI-1482850", "name": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524083", "species_1498773" ], "products": [ "species_1524072", "species_1524089" ], "modifiers": [ [ "species_10597993", "catalyst" ] ], "additional_components": [ "DDB_G0291922" ] }, "reaction_10605155": { "compartment": "compartment_876", "id": "reaction_10605155", "reactome": "R-DDI-5333678", "name": "CPNEs bind PL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605151", "species_171142" ], "products": [ "species_10605153" ], "modifiers": [ [ "species_74016", "catalyst" ] ], "additional_components": [ "Q54P51", "DDB_G0284791", "Q55GG1", "DDB_G0267688", "Q1ZXB3", "DDB_G0291498", "Q54FY7", "DDB_G0290529", "Q7YXU4", "DDB_G0293008", "Q86K21", "DDB_G0272875", "species_171142", "Q54P51", "DDB_G0284791", "Q55GG1", "DDB_G0267688", "Q1ZXB3", "DDB_G0291498", "Q54FY7", "DDB_G0290529", "Q7YXU4", "DDB_G0293008", "Q86K21", "DDB_G0272875" ] }, "reaction_10598166": { "compartment": "compartment_12045", "id": "reaction_10598166", "reactome": "R-DDI-1483121", "name": "PA is converted to CDP-DAG by CDS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_426755" ], "products": [ "species_111294", "species_426955" ], "modifiers": [ [ "species_10598163", "catalyst" ] ], "additional_components": [ "Q55D90", "DDB_G0269742", "species_29926" ] }, "reaction_10598092": { "compartment": "compartment_12045", "id": "reaction_10598092", "reactome": "R-DDI-1482976", "name": "CDP-DAG is converted to PI by CDIPT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426955", "species_426910" ], "products": [ "species_426639", "species_109395" ], "modifiers": [ [ "species_10598089", "catalyst" ] ], "additional_components": [ "Q54P27", "DDB_G0284857", "species_29926", "species_266099" ] }, "reaction_10620477": { "compartment": "compartment_70101", "id": "reaction_10620477", "reactome": "R-DDI-8869241", "name": "PITPNM1,2,3 exchange PI for PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426639", "species_1602448" ], "products": [ "species_426755", "species_426658" ], "modifiers": [ [ "species_10620474", "catalyst" ] ], "additional_components": [ "Q55DN9", "DDB_G0276935", "Q54EA5", "DDB_G0291694", "Q86KP6", "DDB_G0276935", "Q55DP0", "DDB_G0276935", "Q9NCL7", "DDB_G0274579", "Q54D93", "DDB_G0292426", "Q54VC7", "DDB_G0280449" ] }, "reaction_10598213": { "compartment": "compartment_12045", "id": "reaction_10598213", "reactome": "R-DDI-1483186", "name": "PC is converted to PS by PTDSS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_200736" ], "products": [ "species_264618", "species_1500646" ], "modifiers": [ [ "species_10598210", "catalyst" ] ], "additional_components": [ "DDB_G0278159" ] }, "reaction_10598156": { "compartment": "compartment_12045", "id": "reaction_10598156", "reactome": "R-DDI-1483089", "name": "PE is converted to PS by PTDSS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736", "species_1500581" ], "products": [ "species_1498751", "species_1500646" ], "modifiers": [ [ "species_10598153", "catalyst" ] ], "additional_components": [ "DDB_G0278159" ] }, "reaction_10598171": { "compartment": "compartment_70616", "id": "reaction_10598171", "reactome": "R-DDI-1483165", "name": "PA is converted to CDP-DAG by CDS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524101", "species_110577" ], "products": [ "species_159450", "species_1524064" ], "modifiers": [ [ "species_10598168", "catalyst" ] ], "additional_components": [ "DDB_G0269742" ] }, "reaction_10619810": { "compartment": "compartment_984", "id": "reaction_10619810", "reactome": "R-DDI-8865637", "name": "MFSD2A transports LPC from extracellular region to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8865642", "species_74113" ], "products": [ "species_8865629", "species_83910" ], "modifiers": [ [ "species_10619807", "catalyst" ] ], "additional_components": [ "DDB_G0282159" ] }, "reaction_10598179": { "compartment": "compartment_12045", "id": "reaction_10598179", "reactome": "R-DDI-1483174", "name": "PE is methylated to PC by PEMT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_1500581" ], "products": [ "species_426925", "species_71285" ], "modifiers": [ [ "species_10598176", "catalyst" ] ], "additional_components": [ "DDB_G0282527" ] }, "reaction_10598082": { "compartment": "compartment_20699", "id": "reaction_10598082", "reactome": "R-DDI-1482973", "name": "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524057", "species_1524060" ], "products": [ "species_429785", "species_109395" ], "modifiers": [ [ "species_10598079", "catalyst" ] ], "additional_components": [ "species_29926", "species_266099", "Q54XM0", "DDB_G0278947" ] }, "reaction_10611829": { "compartment": "compartment_876", "id": "reaction_10611829", "reactome": "R-DDI-5694485", "name": "ABHD3 hydrolyses LPC(14:0) to 1AGPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5694502" ], "products": [ "species_5694457", "species_1861754" ], "modifiers": [ [ "species_10611826", "catalyst" ] ], "additional_components": [ "Q55C73", "DDB_G0270192", "Q54H38", "DDB_G0289723" ] }, "reaction_10589593": { "compartment": "compartment_984", "id": "reaction_10589593", "reactome": "R-DDI-372519", "name": "AcCho is hydrolyzed to Cho and acetate by ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_372533" ], "products": [ "species_1524044", "species_264638" ], "modifiers": [ [ "species_10589588", "catalyst" ], [ "species_10589591", "inhibitor" ] ], "additional_components": [ "Q54ET7", "DDB_G0291344", "Q86L18", "DDB_G0291344", "P18142", "DDB_G0283085", "Q54N21", "DDB_G0291344", "Q54WD8", "DDB_G0291344", "P21837", "DDB_G0285419", "Q54ET7", "DDB_G0291344", "Q86L18", "DDB_G0291344", "P18142", "DDB_G0283085", "Q54N21", "DDB_G0291344", "Q54WD8", "DDB_G0291344", "P21837", "DDB_G0285419" ] }, "reaction_10598121": { "compartment": "compartment_70101", "id": "reaction_10598121", "reactome": "R-DDI-1483004", "name": "Cho is phosphorylated to PCho by CHK dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264618", "species_113592" ], "products": [ "species_29370", "species_1524071" ], "modifiers": [ [ "species_10598118", "catalyst" ] ], "additional_components": [ "Q554D8", "DDB_G0275265", "Q869T9", "DDB_G0274955" ] }, "reaction_10598137": { "compartment": "compartment_12045", "id": "reaction_10598137", "reactome": "R-DDI-1483081", "name": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_1524071" ], "products": [ "species_111294", "species_1524060" ], "modifiers": [ [ "species_10598134", "catalyst" ] ], "additional_components": [ "Q54GD2", "DDB_G0290229" ] }, "reaction_10598058": { "compartment": "compartment_12045", "id": "reaction_10598058", "reactome": "R-DDI-1482961", "name": "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524060", "species_1500596" ], "products": [ "species_426925", "species_109395" ], "modifiers": [ [ "species_10598055", "catalyst" ] ], "additional_components": [ "Q8T2Q6", "DDB_G0275235", "Q54XM0", "DDB_G0278947", "Q550W1", "DDB_G0276763", "Q55AQ3", "DDB_G0271794", "species_29926", "species_266099" ] }, "reaction_10592589": { "compartment": "compartment_984", "id": "reaction_10592589", "reactome": "R-DDI-444433", "name": "Cho transports from the extracellular space to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264638" ], "products": [ "species_264618" ], "modifiers": [ [ "species_10592586", "catalyst" ] ], "additional_components": [ "Q54I48", "DDB_G0289013", "Q54IJ2", "DDB_G0288717" ] }, "reaction_10597968": { "compartment": "compartment_12045", "id": "reaction_10597968", "reactome": "R-DDI-1482635", "name": "2-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498730", "species_1500578" ], "products": [ "species_1483256", "species_76194" ], "modifiers": [ [ "species_10597938", "catalyst" ] ], "additional_components": [ "Q54IT8", "DDB_G0288523", "Q55CZ2", "DDB_G0288523", "Q54X10", "DDB_G0279277" ] }, "reaction_10597941": { "compartment": "compartment_12045", "id": "reaction_10597941", "reactome": "R-DDI-1482539", "name": "1-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498740" ], "products": [ "species_1483256", "species_76194" ], "modifiers": [ [ "species_10597938", "catalyst" ] ], "additional_components": [ "Q54IT8", "DDB_G0288523", "Q55CZ2", "DDB_G0288523", "Q54X10", "DDB_G0279277" ] }, "reaction_10597985": { "compartment": "compartment_12045", "id": "reaction_10597985", "reactome": "R-DDI-1482685", "name": "1-acyl LPC is hydrolyzed to GPCho by PLA2[8]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1524028" ], "products": [ "species_1498750", "species_1524021" ], "modifiers": [ [ "species_10597959", "catalyst" ] ], "additional_components": [ "DDB_G0284449" ] }, "reaction_10597962": { "compartment": "compartment_12045", "id": "reaction_10597962", "reactome": "R-DDI-1482612", "name": "2-acyl LPC is hydrolyzed to GPCho by PLA2[8]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_975614" ], "products": [ "species_1498750", "species_1524021" ], "modifiers": [ [ "species_10597959", "catalyst" ] ], "additional_components": [ "DDB_G0284449" ] }, "reaction_10597954": { "compartment": "compartment_12045", "id": "reaction_10597954", "reactome": "R-DDI-1482598", "name": "1-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498733", "species_1500578" ], "products": [ "species_426639", "species_76194" ], "modifiers": [ [ "species_10597951", "catalyst" ] ], "additional_components": [ "DDB_G0278541" ] }, "reaction_10598010": { "compartment": "compartment_12045", "id": "reaction_10598010", "reactome": "R-DDI-1482825", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[11]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426639" ], "products": [ "species_1498733", "species_1524021" ], "modifiers": [ [ "species_10597959", "catalyst" ] ], "additional_components": [ "DDB_G0284449" ] }, "reaction_10597965": { "compartment": "compartment_12045", "id": "reaction_10597965", "reactome": "R-DDI-1482626", "name": "2-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498737", "species_1500578" ], "products": [ "species_426639", "species_76194" ], "modifiers": [ [ "species_10597951", "catalyst" ] ], "additional_components": [ "DDB_G0278541" ] }, "reaction_10598021": { "compartment": "compartment_12045", "id": "reaction_10598021", "reactome": "R-DDI-1482884", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500581" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10597959", "catalyst" ] ], "additional_components": [ "DDB_G0284449" ] }, "reaction_10598023": { "compartment": "compartment_12045", "id": "reaction_10598023", "reactome": "R-DDI-1482887", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500581" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10598004", "catalyst" ] ], "additional_components": [ "DDB_G0283551" ] }, "reaction_10597980": { "compartment": "compartment_12045", "id": "reaction_10597980", "reactome": "R-DDI-1482646", "name": "2-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498729", "species_1500578" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10597977", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541", "Q54X10", "DDB_G0279277" ] }, "reaction_10597983": { "compartment": "compartment_12045", "id": "reaction_10597983", "reactome": "R-DDI-1482667", "name": "1-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498738" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10597977", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541", "Q54X10", "DDB_G0279277" ] }, "reaction_10597988": { "compartment": "compartment_12045", "id": "reaction_10597988", "reactome": "R-DDI-1482691", "name": "2-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498722" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10597972", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541", "Q54X10", "DDB_G0279277" ] }, "reaction_10597975": { "compartment": "compartment_12045", "id": "reaction_10597975", "reactome": "R-DDI-1482636", "name": "1-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498724" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10597972", "catalyst" ] ], "additional_components": [ "Q54XX2", "DDB_G0278541", "Q54X10", "DDB_G0279277" ] }, "reaction_10620264": { "compartment": "compartment_12045", "id": "reaction_10620264", "reactome": "R-DDI-8867876", "name": "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_392417", "species_1500646" ], "products": [ "species_33625", "species_1806234" ], "modifiers": [ [ "species_10620261", "catalyst" ] ], "additional_components": [ "Q86KG4", "DDB_G0272498", "Q54RM1", "DDB_G0283035", "Q54NM4", "DDB_G0285141", "Q55CR3", "DDB_G0269938", "Q55CR2", "DDB_G0269940", "Q86HV4", "DDB_G0276427", "Q86HL8", "DDB_G0274517", "Q54EF5", "DDB_G0291562", "Q8MPQ7", "DDB_G0280053" ] }, "reaction_10601149": { "compartment": "compartment_1598585", "id": "reaction_10601149", "reactome": "R-DDI-2470935", "name": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2537690", "species_10601101", "species_10601141" ], "products": [ "species_10601147" ], "modifiers": [], "additional_components": [ "Q54QR0", "DDB_G0283681", "Q54E85", "DDB_G0291752", "Q552D9", "DDB_G0276101", "Q550H7", "DDB_G0276977", "Q552Q7", "DDB_G0275929", "Q54RK7", "DDB_G0283099", "Q54S35", "DDB_G0282689", "Q54RK7", "DDB_G0283099", "Q54S35", "DDB_G0282689", "Q54QR0", "DDB_G0283681", "Q54E85", "DDB_G0291752", "Q552D9", "DDB_G0276101", "Q550H7", "DDB_G0276977", "Q552Q7", "DDB_G0275929" ] }, "reaction_10626171": { "compartment": "compartment_984", "id": "reaction_10626171", "reactome": "R-DDI-9619024", "name": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_9619052" ], "products": [ "species_8878776", "species_9619021" ], "modifiers": [ [ "species_10611415", "catalyst" ] ], "additional_components": [ "Q54ET7", "DDB_G0291344" ] }, "reaction_10582448": { "compartment": "compartment_7660", "id": "reaction_10582448", "reactome": "R-DDI-77584", "name": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582444", "species_10582432" ], "products": [ "species_10582446" ], "modifiers": [], "additional_components": [ "Q54J82", "DDB_G0288225", "Q75J91", "DDB_G0288225", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54J82", "DDB_G0288225", "Q75J91", "DDB_G0288225" ] }, "reaction_10582469": { "compartment": "compartment_7660", "id": "reaction_10582469", "reactome": "R-DDI-77585", "name": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582446", "species_10582465" ], "products": [ "species_10582467" ], "modifiers": [], "additional_components": [ "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54J82", "DDB_G0288225", "Q75J91", "DDB_G0288225", "Q55A45", "DDB_G0272320", "C7G054", "DDB_G0302414", "Q86L45", "DDB_G0273003", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q54RX0", "DDB_G0282863", "Q55A45", "DDB_G0272320", "C7G054", "DDB_G0302414", "Q86L45", "DDB_G0273003", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q54RX0", "DDB_G0282863", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54J82", "DDB_G0288225", "Q75J91", "DDB_G0288225" ] }, "reaction_10582473": { "compartment": "compartment_7660", "id": "reaction_10582473", "reactome": "R-DDI-77586", "name": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582467" ], "products": [ "species_10582471", "species_10582465" ], "modifiers": [], "additional_components": [ "Q55A45", "DDB_G0272320", "C7G054", "DDB_G0302414", "Q86L45", "DDB_G0273003", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q54RX0", "DDB_G0282863", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54J82", "DDB_G0288225", "Q75J91", "DDB_G0288225", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54J82", "DDB_G0288225", "Q75J91", "DDB_G0288225", "Q55A45", "DDB_G0272320", "C7G054", "DDB_G0302414", "Q86L45", "DDB_G0273003", "Q54XP2", "DDB_G0278821", "Q54F84", "DDB_G0291015", "Q54RX0", "DDB_G0282863" ] }, "reaction_10600404": { "compartment": "compartment_70101", "id": "reaction_10600404", "reactome": "R-DDI-2161549", "name": "PGH2 is reduced to PGF2a by AKR1C3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_265283", "species_29364" ], "products": [ "species_29366", "species_879535" ], "modifiers": [ [ "species_10586594", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10589015": { "compartment": "compartment_70101", "id": "reaction_10589015", "reactome": "R-DDI-265295", "name": "Prostaglandin E synthase isomerizes PGH2 to PGE2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265283" ], "products": [ "species_265287" ], "modifiers": [ [ "species_10589012", "catalyst" ] ], "additional_components": [ "DDB_G0268042" ] }, "reaction_10600407": { "compartment": "compartment_70101", "id": "reaction_10600407", "reactome": "R-DDI-2161614", "name": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_879629" ], "products": [ "species_29366", "species_2142710" ], "modifiers": [ [ "species_10586594", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10583842": { "compartment": "compartment_5460", "id": "reaction_10583842", "reactome": "R-DDI-159567", "name": "salicylic acid + Coenzyme A + ATP => salicylate-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_159559" ], "products": [ "species_159448", "species_159450", "species_159557" ], "modifiers": [ [ "species_10583839", "catalyst" ] ], "additional_components": [ "Q8SSN6", "DDB_G0276337", "Q551W4", "DDB_G0276337" ] }, "reaction_10585793": { "compartment": "compartment_5460", "id": "reaction_10585793", "reactome": "R-DDI-177157", "name": "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_177153" ], "products": [ "species_159448", "species_159450", "species_177137" ], "modifiers": [ [ "species_10583822", "catalyst" ] ], "additional_components": [ "Q8SSN6", "DDB_G0276337", "Q551W4", "DDB_G0276337" ] }, "reaction_10583825": { "compartment": "compartment_5460", "id": "reaction_10583825", "reactome": "R-DDI-159443", "name": "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_159446" ], "products": [ "species_159448", "species_159450", "species_159447" ], "modifiers": [ [ "species_10583822", "catalyst" ] ], "additional_components": [ "Q8SSN6", "DDB_G0276337", "Q551W4", "DDB_G0276337" ] }, "reaction_10625238": { "compartment": "compartment_74700", "id": "reaction_10625238", "reactome": "R-DDI-9018774", "name": "RHOBTB1 binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10625234" ], "products": [ "species_10625236" ], "modifiers": [], "additional_components": [ "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "species_29438" ] }, "reaction_10625269": { "compartment": "compartment_876", "id": "reaction_10625269", "reactome": "R-DDI-9018778", "name": "RHOBTB1 binds interacting proteins at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625236", "species_10625265" ], "products": [ "species_10625267" ], "modifiers": [], "additional_components": [ "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "species_29438", "Q54NZ5", "DDB_G0284903", "B0G0Y8", "DDB_G0268634", "Q54NZ5", "DDB_G0284903", "B0G0Y8", "DDB_G0268634", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "species_29438" ] }, "reaction_10625322": { "compartment": "compartment_74700", "id": "reaction_10625322", "reactome": "R-DDI-9018787", "name": "RHOBTB2 binds interacting proteins at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625307", "species_10625318" ], "products": [ "species_10625320" ], "modifiers": [], "additional_components": [ "P34150", "DDB_G0291976", "P34149", "DDB_G0293526", "Q23862", "DDB_G0280975", "Q1ZXJ6", "DDB_G0278011", "Q54N82", "DDB_G0285453", "Q54HZ7", "DDB_G0289103", "Q9GPQ8", "DDB_G0292816", "Q54YY4", "DDB_G0278009", "Q9GPR7", "DDB_G0269240", "Q9GPQ9", "DDB_G0292560", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "P34148", "DDB_G0279605", "P34146", "DDB_G0282365", "species_29438", "Q54NZ5", "DDB_G0284903", "Q54NZ5", "DDB_G0284903", "P34150", "DDB_G0291976", "P34149", "DDB_G0293526", "Q23862", "DDB_G0280975", "Q1ZXJ6", "DDB_G0278011", "Q54N82", "DDB_G0285453", "Q54HZ7", "DDB_G0289103", "Q9GPQ8", "DDB_G0292816", "Q54YY4", "DDB_G0278009", "Q9GPR7", "DDB_G0269240", "Q9GPQ9", "DDB_G0292560", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "P34144", "DDB_G0277869", "P34148", "DDB_G0279605", "P34146", "DDB_G0282365", "species_29438" ] }, "reaction_10625366": { "compartment": "compartment_876", "id": "reaction_10625366", "reactome": "R-DDI-9018794", "name": "RHOV binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625360", "species_10625362" ], "products": [ "species_10625364" ], "modifiers": [], "additional_components": [ "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "species_29438", "Q55DD4", "DDB_G0269696", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q55DD4", "DDB_G0269696", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "species_29438" ] }, "reaction_10625370": { "compartment": "compartment_876", "id": "reaction_10625370", "reactome": "R-DDI-9018798", "name": "RHOV binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10625368" ], "products": [ "species_29420", "species_10625360" ], "modifiers": [], "additional_components": [ "species_29420", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "species_29438" ] }, "reaction_10627382": { "compartment": "compartment_876", "id": "reaction_10627382", "reactome": "R-DDI-9691168", "name": "RAC1 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583374" ], "products": [ "species_10605813" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10624907": { "compartment": "compartment_876", "id": "reaction_10624907", "reactome": "R-DDI-9013145", "name": "RAC1 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583374", "species_10624903" ], "products": [ "species_10624905" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "Q54WW0", "DDB_G0290421", "Q54G40", "DDB_G0290421", "Q867X6", "DDB_G0267460", "Q86GL4", "DDB_G0287101", "Q54F44", "DDB_G0291117", "Q867T7", "DDB_G0288773", "Q869Q3", "DDB_G0274519", "Q55FT9", "DDB_G0267956", "Q54X65", "DDB_G0279175", "Q6UK63", "DDB_G0287855", "Q55DD4", "DDB_G0269696", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q54I34", "DDB_G0289033", "Q54K32", "DDB_G0287585", "O00899", "DDB_G0269140", "Q54Z25", "DDB_G0277949", "Q54WR4", "DDB_G0279483", "Q54Q49", "DDB_G0284155", "Q54UK0", "DDB_G0281031", "Q9XYS3", "DDB_G0289653", "Q54WW0", "DDB_G0290421", "Q54G40", "DDB_G0290421", "Q867X6", "DDB_G0267460", "Q86GL4", "DDB_G0287101", "Q54F44", "DDB_G0291117", "Q867T7", "DDB_G0288773", "Q869Q3", "DDB_G0274519", "Q55FT9", "DDB_G0267956", "Q54X65", "DDB_G0279175", "Q6UK63", "DDB_G0287855", "Q55DD4", "DDB_G0269696", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q54I34", "DDB_G0289033", "Q54K32", "DDB_G0287585", "O00899", "DDB_G0269140", "Q54Z25", "DDB_G0277949", "Q54WR4", "DDB_G0279483", "Q54Q49", "DDB_G0284155", "Q54UK0", "DDB_G0281031", "Q9XYS3", "DDB_G0289653", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10624927": { "compartment": "compartment_876", "id": "reaction_10624927", "reactome": "R-DDI-9013147", "name": "RAC1 GDIs block activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599930", "species_10624923" ], "products": [ "species_10624925" ], "modifiers": [], "additional_components": [ "species_29420", "P34144", "DDB_G0277869", "Q95UP9", "DDB_G0280049", "Q95UQ1", "DDB_G0291077", "Q95UP9", "DDB_G0280049", "Q95UQ1", "DDB_G0291077", "P34144", "DDB_G0277869", "species_29420" ] }, "reaction_10624700": { "compartment": "compartment_876", "id": "reaction_10624700", "reactome": "R-DDI-9013143", "name": "RAC1 GEFs activate RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10599930" ], "products": [ "species_10583374", "species_29420" ], "modifiers": [ [ "species_10624697", "catalyst" ] ], "additional_components": [ "species_29420", "P34144", "DDB_G0277869", "P34144", "DDB_G0277869", "species_29438", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "Q54LN3", "DDB_G0286543", "Q55BQ8", "DDB_G0292004", "Q54DS6", "DDB_G0291974", "Q54DW1", "DDB_G0292004", "Q54PB7", "DDB_G0292004", "Q54SG9", "DDB_G0282475", "Q54BV5", "DDB_G0293396", "Q54YP1", "DDB_G0293396", "Q54XW8", "DDB_G0278703", "Q54C56", "DDB_G0293396", "Q55DL8", "DDB_G0293396", "Q54BY9", "DDB_G0293396", "Q54YZ6", "DDB_G0277987", "Q54F88", "DDB_G0293396", "Q86HN1", "DDB_G0293396", "Q54DW7", "DDB_G0293396", "Q55G61", "DDB_G0268354", "Q54GP2", "DDB_G0293396", "Q54G10", "DDB_G0293396", "Q86K95", "DDB_G0293396", "Q54NG0", "DDB_G0293396", "Q54J14", "DDB_G0288377", "Q54P81", "DDB_G0293396", "Q54P24", "DDB_G0284845", "Q54SR5", "DDB_G0293396", "Q54S15", "DDB_G0293396", "Q54XA7", "DDB_G0293396", "Q54VX2", "DDB_G0293396", "Q54L90", "DDB_G0286773", "Q54WL2", "DDB_G0279569", "Q552M5", "DDB_G0276019", "Q86G47", "DDB_G0289665", "Q8IS18", "DDB_G0269252", "Q8IS19", "DDB_G0289667", "Q8SSQ3", "DDB_G0274607" ] }, "reaction_10624829": { "compartment": "compartment_876", "id": "reaction_10624829", "reactome": "R-DDI-9013144", "name": "RAC1 GAPs stimulate RAC1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583374", "species_29356" ], "products": [ "species_29372", "species_10599930" ], "modifiers": [ [ "species_10624826", "catalyst" ] ], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "species_29420", "P34144", "DDB_G0277869", "Q54BP9", "DDB_G0293510", "Q1ZXE1", "DDB_G0287895", "Q54E35", "DDB_G0291840", "Q54BF1", "DDB_G0293654", "Q86B03", "DDB_G0276833", "Q54PG5", "DDB_G0284571", "Q54FG5", "DDB_G0290873", "Q86I31", "DDB_G0275085", "Q54XE8", "DDB_G0279009", "Q553X3", "DDB_G0275185", "Q54MV3", "DDB_G0285641", "Q86IG9", "DDB_G0272694" ] }, "reaction_10624960": { "compartment": "compartment_70101", "id": "reaction_10624960", "reactome": "R-DDI-9014293", "name": "RAC2 GDIs block activation of RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624954", "species_10624919" ], "products": [ "species_10624958" ], "modifiers": [], "additional_components": [ "Q54N82", "DDB_G0285453", "P34148", "DDB_G0279605", "Q54YY4", "DDB_G0278009", "P34149", "DDB_G0293526", "Q9GPQ8", "DDB_G0292816", "P34144", "DDB_G0277869", "P34150", "DDB_G0291976", "Q9GPQ9", "DDB_G0292560", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q23862", "DDB_G0280975", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "Q54HZ7", "DDB_G0289103", "P34146", "DDB_G0282365", "Q9GPS3", "DDB_G0276967", "species_29420", "Q95UP9", "DDB_G0280049", "Q95UQ1", "DDB_G0291077", "Q95UP9", "DDB_G0280049", "Q95UQ1", "DDB_G0291077", "Q9GPQ9", "DDB_G0292560", "Q9GPR7", "DDB_G0269240", "Q9GPS0", "DDB_G0269178", "Q9GPS3", "DDB_G0276967", "O96390", "DDB_G0269176", "P34144", "DDB_G0277869", "P34145", "DDB_G0268622", "P34146", "DDB_G0282365", "P34148", "DDB_G0279605", "P34149", "DDB_G0293526", "P34150", "DDB_G0291976", "Q1ZXJ6", "DDB_G0278011", "Q23862", "DDB_G0280975", "Q54HZ7", "DDB_G0289103", "Q54N82", "DDB_G0285453", "Q54YY4", "DDB_G0278009", "Q9GPQ8", "DDB_G0292816", "species_29420" ] }, "reaction_10624982": { "compartment": "compartment_876", "id": "reaction_10624982", "reactome": "R-DDI-9014420", "name": "RAC2 translocates to the phagocytic vesicle membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583458" ], "products": [ "species_10606729" ], "modifiers": [], "additional_components": [ "Q54N82", "DDB_G0285453", "P34148", "DDB_G0279605", "Q54YY4", "DDB_G0278009", "P34149", "DDB_G0293526", "Q9GPQ8", "DDB_G0292816", "P34144", "DDB_G0277869", "P34150", "DDB_G0291976", "Q9GPQ9", "DDB_G0292560", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q23862", "DDB_G0280975", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "Q54HZ7", "DDB_G0289103", "P34146", "DDB_G0282365", "Q9GPS3", "DDB_G0276967", "species_29438", "Q9GPR7", "DDB_G0269240", "Q9GPS0", "DDB_G0269178", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34144", "DDB_G0277869", "P34145", "DDB_G0268622", "P34146", "DDB_G0282365", "P34148", "DDB_G0279605", "P34149", "DDB_G0293526", "P34150", "DDB_G0291976", "Q1ZXJ6", "DDB_G0278011", "Q23862", "DDB_G0280975", "Q54HZ7", "DDB_G0289103", "Q54N82", "DDB_G0285453", "Q54YY4", "DDB_G0278009", "Q9GPQ8", "DDB_G0292816", "Q9GPQ9", "DDB_G0292560", "species_29438" ] }, "reaction_10627542": { "compartment": "compartment_876", "id": "reaction_10627542", "reactome": "R-DDI-9714480", "name": "RAC2 translocates to the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583458" ], "products": [ "species_10627524" ], "modifiers": [], "additional_components": [ "Q54N82", "DDB_G0285453", "P34148", "DDB_G0279605", "Q54YY4", "DDB_G0278009", "P34149", "DDB_G0293526", "Q9GPQ8", "DDB_G0292816", "P34144", "DDB_G0277869", "P34150", "DDB_G0291976", "Q9GPQ9", "DDB_G0292560", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q23862", "DDB_G0280975", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "Q54HZ7", "DDB_G0289103", "P34146", "DDB_G0282365", "Q9GPS3", "DDB_G0276967", "species_29438", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "species_29438" ] }, "reaction_10624980": { "compartment": "compartment_70101", "id": "reaction_10624980", "reactome": "R-DDI-9014296", "name": "RAC2 GEFs activate RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10624954" ], "products": [ "species_29420", "species_10583458" ], "modifiers": [ [ "species_10624977", "catalyst" ] ], "additional_components": [ "Q54N82", "DDB_G0285453", "P34148", "DDB_G0279605", "Q54YY4", "DDB_G0278009", "P34149", "DDB_G0293526", "Q9GPQ8", "DDB_G0292816", "P34144", "DDB_G0277869", "P34150", "DDB_G0291976", "Q9GPQ9", "DDB_G0292560", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q23862", "DDB_G0280975", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "Q54HZ7", "DDB_G0289103", "P34146", "DDB_G0282365", "Q9GPS3", "DDB_G0276967", "species_29420", "Q54N82", "DDB_G0285453", "P34148", "DDB_G0279605", "Q54YY4", "DDB_G0278009", "P34149", "DDB_G0293526", "Q9GPQ8", "DDB_G0292816", "P34144", "DDB_G0277869", "P34150", "DDB_G0291976", "Q9GPQ9", "DDB_G0292560", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q23862", "DDB_G0280975", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "Q54HZ7", "DDB_G0289103", "P34146", "DDB_G0282365", "Q9GPS3", "DDB_G0276967", "species_29438", "Q54SG9", "DDB_G0282475", "Q54LN3", "DDB_G0286543", "Q54PB7", "DDB_G0292004" ] }, "reaction_10627540": { "compartment": "compartment_17906", "id": "reaction_10627540", "reactome": "R-DDI-9714477", "name": "RAC2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627524", "species_10627536" ], "products": [ "species_10627538" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "species_29438", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "species_29438" ] }, "reaction_10624970": { "compartment": "compartment_70101", "id": "reaction_10624970", "reactome": "R-DDI-9014294", "name": "RAC2 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624966", "species_10583458" ], "products": [ "species_10624968" ], "modifiers": [], "additional_components": [ "Q54K32", "DDB_G0287585", "Q54Z25", "DDB_G0277949", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "Q54N82", "DDB_G0285453", "P34148", "DDB_G0279605", "Q54YY4", "DDB_G0278009", "P34149", "DDB_G0293526", "Q9GPQ8", "DDB_G0292816", "P34144", "DDB_G0277869", "P34150", "DDB_G0291976", "Q9GPQ9", "DDB_G0292560", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q23862", "DDB_G0280975", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "Q54HZ7", "DDB_G0289103", "P34146", "DDB_G0282365", "Q9GPS3", "DDB_G0276967", "species_29438", "Q54N82", "DDB_G0285453", "P34148", "DDB_G0279605", "Q54YY4", "DDB_G0278009", "P34149", "DDB_G0293526", "Q9GPQ8", "DDB_G0292816", "P34144", "DDB_G0277869", "P34150", "DDB_G0291976", "Q9GPQ9", "DDB_G0292560", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q23862", "DDB_G0280975", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "Q54HZ7", "DDB_G0289103", "P34146", "DDB_G0282365", "Q9GPS3", "DDB_G0276967", "species_29438", "Q54K32", "DDB_G0287585", "Q54Z25", "DDB_G0277949", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459" ] }, "reaction_10624975": { "compartment": "compartment_70101", "id": "reaction_10624975", "reactome": "R-DDI-9014295", "name": "RAC2 GAPs stimulate RAC2 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10583458" ], "products": [ "species_29372", "species_10624954" ], "modifiers": [ [ "species_10624972", "catalyst" ] ], "additional_components": [ "Q54N82", "DDB_G0285453", "P34148", "DDB_G0279605", "Q54YY4", "DDB_G0278009", "P34149", "DDB_G0293526", "Q9GPQ8", "DDB_G0292816", "P34144", "DDB_G0277869", "P34150", "DDB_G0291976", "Q9GPQ9", "DDB_G0292560", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q23862", "DDB_G0280975", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "Q54HZ7", "DDB_G0289103", "P34146", "DDB_G0282365", "Q9GPS3", "DDB_G0276967", "species_29438", "Q54N82", "DDB_G0285453", "P34148", "DDB_G0279605", "Q54YY4", "DDB_G0278009", "P34149", "DDB_G0293526", "Q9GPQ8", "DDB_G0292816", "P34144", "DDB_G0277869", "P34150", "DDB_G0291976", "Q9GPQ9", "DDB_G0292560", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q23862", "DDB_G0280975", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "Q54HZ7", "DDB_G0289103", "P34146", "DDB_G0282365", "Q9GPS3", "DDB_G0276967", "species_29420", "Q54FF4", "DDB_G0290891", "Q8SSN9", "DDB_G0274243", "Q54TH9", "DDB_G0281739", "Q54XT6", "DDB_G0278755", "Q54J98", "DDB_G0288205", "Q55DW9", "DDB_G0269496", "Q54ND2", "DDB_G0285391" ] }, "reaction_10627580": { "compartment": "compartment_876", "id": "reaction_10627580", "reactome": "R-DDI-9714483", "name": "RAC2 translocates to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583458" ], "products": [ "species_10627578" ], "modifiers": [], "additional_components": [ "Q54N82", "DDB_G0285453", "P34148", "DDB_G0279605", "Q54YY4", "DDB_G0278009", "P34149", "DDB_G0293526", "Q9GPQ8", "DDB_G0292816", "P34144", "DDB_G0277869", "P34150", "DDB_G0291976", "Q9GPQ9", "DDB_G0292560", "Q1ZXJ6", "DDB_G0278011", "O96390", "DDB_G0269176", "Q9GPR7", "DDB_G0269240", "Q23862", "DDB_G0280975", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "Q54HZ7", "DDB_G0289103", "P34146", "DDB_G0282365", "Q9GPS3", "DDB_G0276967", "species_29438", "P34150", "DDB_G0291976", "P34149", "DDB_G0293526", "Q23862", "DDB_G0280975", "Q1ZXJ6", "DDB_G0278011", "Q54N82", "DDB_G0285453", "Q54HZ7", "DDB_G0289103", "Q9GPQ8", "DDB_G0292816", "Q54YY4", "DDB_G0278009", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "Q9GPQ9", "DDB_G0292560", "Q9GPS3", "DDB_G0276967", "Q9GPS0", "DDB_G0269178", "P34145", "DDB_G0268622", "O96390", "DDB_G0269176", "P34148", "DDB_G0279605", "P34146", "DDB_G0282365", "species_29438" ] }, "reaction_10625394": { "compartment": "compartment_876", "id": "reaction_10625394", "reactome": "R-DDI-9018807", "name": "RAC3 GDIs block activation of RAC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625388", "species_10625374" ], "products": [ "species_10625392" ], "modifiers": [], "additional_components": [ "species_29420", "P34147", "DDB_G0286555", "P34147", "DDB_G0286555", "species_29420" ] }, "reaction_10627586": { "compartment": "compartment_876", "id": "reaction_10627586", "reactome": "R-DDI-9714694", "name": "RAC3 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625376" ], "products": [ "species_10627584" ], "modifiers": [], "additional_components": [ "species_29438", "P34147", "DDB_G0286555", "P34147", "DDB_G0286555", "species_29438" ] }, "reaction_10625381": { "compartment": "compartment_876", "id": "reaction_10625381", "reactome": "R-DDI-9018804", "name": "RAC3 GEFs activate RAC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10625374" ], "products": [ "species_29420", "species_10625376" ], "modifiers": [ [ "species_10625378", "catalyst" ] ], "additional_components": [ "species_29420", "P34147", "DDB_G0286555", "species_29438", "P34147", "DDB_G0286555", "Q54SG9", "DDB_G0282475" ] }, "reaction_10625386": { "compartment": "compartment_876", "id": "reaction_10625386", "reactome": "R-DDI-9018806", "name": "RAC3 GAPs stimulate RAC3 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10625376" ], "products": [ "species_29372", "species_10625374" ], "modifiers": [ [ "species_10625383", "catalyst" ] ], "additional_components": [ "species_29438", "P34147", "DDB_G0286555", "species_29420", "P34147", "DDB_G0286555", "Q54FF4", "DDB_G0290891", "Q8SSN9", "DDB_G0274243", "Q54TH9", "DDB_G0281739", "Q54XT6", "DDB_G0278755", "Q54J98", "DDB_G0288205", "Q55DW9", "DDB_G0269496", "Q54ND2", "DDB_G0285391", "Q54BF1", "DDB_G0293654", "Q86B03", "DDB_G0276833", "Q54PG5", "DDB_G0284571", "Q54E35", "DDB_G0291840", "Q54FG5", "DDB_G0290873", "Q86I31", "DDB_G0275085", "Q54XE8", "DDB_G0279009", "Q553X3", "DDB_G0275185", "Q54MV3", "DDB_G0285641", "Q86IG9", "DDB_G0272694" ] }, "reaction_10625404": { "compartment": "compartment_876", "id": "reaction_10625404", "reactome": "R-DDI-9018808", "name": "RAC3 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625400", "species_10625376" ], "products": [ "species_10625402" ], "modifiers": [], "additional_components": [ "Q867X6", "DDB_G0267460", "Q86GL4", "DDB_G0287101", "Q54F44", "DDB_G0291117", "Q867T7", "DDB_G0288773", "Q869Q3", "DDB_G0274519", "Q55FT9", "DDB_G0267956", "Q54X65", "DDB_G0279175", "Q6UK63", "DDB_G0287855", "Q9XYS3", "DDB_G0289653", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459", "species_29438", "P34147", "DDB_G0286555", "species_29438", "P34147", "DDB_G0286555", "Q867X6", "DDB_G0267460", "Q86GL4", "DDB_G0287101", "Q54F44", "DDB_G0291117", "Q867T7", "DDB_G0288773", "Q869Q3", "DDB_G0274519", "Q55FT9", "DDB_G0267956", "Q54X65", "DDB_G0279175", "Q6UK63", "DDB_G0287855", "Q9XYS3", "DDB_G0289653", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459" ] }, "reaction_10625193": { "compartment": "compartment_876", "id": "reaction_10625193", "reactome": "R-DDI-9018766", "name": "RHOU binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625189", "species_10625172" ], "products": [ "species_10625191" ], "modifiers": [], "additional_components": [ "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "species_29438", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "species_29438", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459" ] }, "reaction_10625198": { "compartment": "compartment_876", "id": "reaction_10625198", "reactome": "R-DDI-9018768", "name": "RHOU auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10625195" ], "products": [ "species_29420", "species_10625172" ], "modifiers": [ [ "species_10625195", "catalyst" ] ], "additional_components": [ "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "species_29420", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "species_29438", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "species_29420" ] }, "reaction_10625079": { "compartment": "compartment_876", "id": "reaction_10625079", "reactome": "R-DDI-9018756", "name": "RHOH binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10625063" ], "products": [ "species_10625065" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "species_29438" ] }, "reaction_10625077": { "compartment": "compartment_876", "id": "reaction_10625077", "reactome": "R-DDI-9018754", "name": "GDIs bind RHOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625065", "species_10625073" ], "products": [ "species_10625075" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "species_29438", "Q95UP9", "DDB_G0280049", "Q95UQ1", "DDB_G0291077", "Q95UP9", "DDB_G0280049", "Q95UQ1", "DDB_G0291077", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "species_29438" ] }, "reaction_10625134": { "compartment": "compartment_876", "id": "reaction_10625134", "reactome": "R-DDI-9018758", "name": "RHOH binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625065", "species_10625130" ], "products": [ "species_10625132" ], "modifiers": [], "additional_components": [ "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "species_29438", "Q55DD4", "DDB_G0269696", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q55DD4", "DDB_G0269696", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "Q55GV3", "DDB_G0267450", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "species_29438" ] }, "reaction_10605858": { "compartment": "compartment_876", "id": "reaction_10605858", "reactome": "R-DDI-5626549", "name": "IQGAPs bind CALM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605847", "species_10587556" ], "products": [ "species_10605853" ], "modifiers": [], "additional_components": [ "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "Q54K32", "DDB_G0287585", "P34144", "DDB_G0277869", "species_29438", "Q7Z2B8", "DDB_G0277917", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "species_74112", "Q7Z2B8", "DDB_G0277917", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "species_74112", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "Q54K32", "DDB_G0287585", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10605849": { "compartment": "compartment_70101", "id": "reaction_10605849", "reactome": "R-DDI-5626469", "name": "GTP-bound RAC1 and CDC42 bind IQGAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583374", "species_10605845" ], "products": [ "species_10605847" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "Q54K32", "DDB_G0287585", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "Q54K32", "DDB_G0287585", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10605855": { "compartment": "compartment_70101", "id": "reaction_10605855", "reactome": "R-DDI-5626507", "name": "IQGAPs bind F-actin, which is inhibited by calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599576", "species_10605847" ], "products": [ "species_10605851" ], "modifiers": [ [ "species_10605853", "inhibitor" ] ], "additional_components": [ "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54L54", "DDB_G0286893", "species_113592", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "Q54K32", "DDB_G0287585", "P34144", "DDB_G0277869", "species_29438", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "Q54K32", "DDB_G0287585", "P34144", "DDB_G0277869", "species_29438", "Q54PQ2", "DDB_G0287981", "Q553U6", "DDB_G0275023", "Q554S6", "DDB_G0274131", "Q55CU2", "DDB_G0269902", "Q55DS6", "DDB_G0287981", "P07828", "DDB_G0289489", "Q55DY5", "DDB_G0287981", "P07829", "DDB_G0289487", "Q55EU6", "DDB_G0268744", "P07830", "DDB_G0269234", "Q54GX7", "DDB_G0289811", "Q54HE7", "DDB_G0289511", "Q54HE9", "DDB_G0289533", "Q54HF0", "DDB_G0289507", "Q54HF1", "DDB_G0289505", "Q54JL1", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q54L54", "DDB_G0286893", "species_113592", "Q7Z2B8", "DDB_G0277917", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "species_74112", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "Q54K32", "DDB_G0287585", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10606803": { "compartment": "compartment_70101", "id": "reaction_10606803", "reactome": "R-DDI-5668932", "name": "PAK2 phosphorylates myosin regulatory light chain (MRLC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606794", "species_113592" ], "products": [ "species_29370", "species_10606800" ], "modifiers": [ [ "species_10605892", "catalyst" ] ], "additional_components": [ "P08799", "DDB_G0286355", "P09402", "DDB_G0277859", "P13833", "DDB_G0276077", "P08799", "DDB_G0286355", "P09402", "DDB_G0277859", "P13833", "DDB_G0276077", "Q869N2", "DDB_G0276459", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450" ] }, "reaction_10624235": { "compartment": "compartment_70101", "id": "reaction_10624235", "reactome": "R-DDI-8981926", "name": "RAC1 and CDC42 activate PAK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590382", "species_10583374" ], "products": [ "species_10590380", "species_10605872" ], "modifiers": [], "additional_components": [ "Q55GV3", "DDB_G0267450", "P34144", "DDB_G0277869", "species_29438", "DDB_G0267450", "Q55GV3", "DDB_G0267450", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10605901": { "compartment": "compartment_70101", "id": "reaction_10605901", "reactome": "R-DDI-5627775", "name": "Autophosphorylation of PAK1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10605874" ], "products": [ "species_10583374", "species_10605898", "species_29370" ], "modifiers": [ [ "species_10605874", "catalyst" ] ], "additional_components": [ "Q55GV3", "DDB_G0267450", "P34144", "DDB_G0277869", "species_29438", "Q55DD4", "DDB_G0269696", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "P34144", "DDB_G0277869", "species_29438", "Q869N2", "DDB_G0276459", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55GV3", "DDB_G0267450", "P34144", "DDB_G0277869", "species_29438", "Q55DD4", "DDB_G0269696", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459" ] }, "reaction_10624237": { "compartment": "compartment_70101", "id": "reaction_10624237", "reactome": "R-DDI-8981931", "name": "RAC1 and CDC42 activate PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583374", "species_10590378" ], "products": [ "species_10605870", "species_10590376" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459", "P34144", "DDB_G0277869", "species_29438", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459" ] }, "reaction_10606784": { "compartment": "compartment_70101", "id": "reaction_10606784", "reactome": "R-DDI-5668731", "name": "NOX3 complex:RAC1:GTP generates superoxide from oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_352327" ], "products": [ "species_70106", "species_29366", "species_3299686" ], "modifiers": [ [ "species_10606781", "catalyst" ] ], "additional_components": [ "Q867X6", "DDB_G0267460", "Q9XYS3", "DDB_G0289653", "Q54F44", "DDB_G0291117", "Q86GL4", "DDB_G0287101", "Q867T7", "DDB_G0288773", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10606786": { "compartment": "compartment_876", "id": "reaction_10606786", "reactome": "R-DDI-5668735", "name": "RAC1:GTP binds NOX3 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583374", "species_10606779" ], "products": [ "species_10606781" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "Q867X6", "DDB_G0267460", "Q9XYS3", "DDB_G0289653", "Q54F44", "DDB_G0291117", "Q86GL4", "DDB_G0287101", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "Q9XYS3", "DDB_G0289653", "Q54F44", "DDB_G0291117", "Q86GL4", "DDB_G0287101", "Q867T7", "DDB_G0288773", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10606759": { "compartment": "compartment_876", "id": "reaction_10606759", "reactome": "R-DDI-5668714", "name": "RAC1:GTP binds NOX1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583374", "species_10606755" ], "products": [ "species_10606757" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "Q867X6", "DDB_G0267460", "Q86GL4", "DDB_G0287101", "Q54F44", "DDB_G0291117", "Q867T7", "DDB_G0288773", "Q867X6", "DDB_G0267460", "Q86GL4", "DDB_G0287101", "Q54F44", "DDB_G0291117", "Q867T7", "DDB_G0288773", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10606762": { "compartment": "compartment_70101", "id": "reaction_10606762", "reactome": "R-DDI-5668718", "name": "NOX1 complex:RAC1:GTP generates superoxide from oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29364", "species_352327" ], "products": [ "species_70106", "species_29366", "species_3299686" ], "modifiers": [ [ "species_10606757", "catalyst" ] ], "additional_components": [ "Q867X6", "DDB_G0267460", "Q86GL4", "DDB_G0287101", "Q54F44", "DDB_G0291117", "Q867T7", "DDB_G0288773", "P34144", "DDB_G0277869", "species_29438" ] }, "reaction_10613711": { "compartment": "compartment_1222693", "id": "reaction_10613711", "reactome": "R-DDI-6798174", "name": "PIK3C3:PIK3R4 phosphorylates PI to PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524165" ], "products": [ "species_1629751", "species_29370" ], "modifiers": [ [ "species_10613708", "catalyst" ] ], "additional_components": [ "P54676", "DDB_G0289601", "Q54S77", "DDB_G0282627" ] }, "reaction_10627463": { "compartment": "compartment_263163", "id": "reaction_10627463", "reactome": "R-DDI-9706390", "name": "RHOBTB3 binds interacting proteins at trans-Golgi network", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627457", "species_10627459" ], "products": [ "species_10627461" ], "modifiers": [], "additional_components": [ "species_113592", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "P36411", "DDB_G0269236", "Q54FK8", "DDB_G0290829", "Q1ZXB9", "DDB_G0290831", "Q1ZXB8", "DDB_G0294571", "Q552H0", "DDB_G0294571", "Q54FK4", "DDB_G0290833", "Q54FK2", "DDB_G0290793", "Q54FK7", "DDB_G0290779", "Q54FK5", "DDB_G0290789", "Q54NZ5", "DDB_G0284903", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "P36411", "DDB_G0269236", "Q54FK8", "DDB_G0290829", "Q1ZXB9", "DDB_G0290831", "Q1ZXB8", "DDB_G0294571", "Q552H0", "DDB_G0294571", "Q54FK4", "DDB_G0290833", "Q54FK2", "DDB_G0290793", "Q54FK7", "DDB_G0290779", "Q54FK5", "DDB_G0290789", "Q54NZ5", "DDB_G0284903", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "species_113592", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967" ] }, "reaction_10627465": { "compartment": "compartment_263163", "id": "reaction_10627465", "reactome": "R-DDI-9706393", "name": "RHOBTB3 binds ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627455", "species_113592" ], "products": [ "species_10627457" ], "modifiers": [], "additional_components": [ "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "species_113592", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967" ] }, "reaction_10627470": { "compartment": "compartment_263163", "id": "reaction_10627470", "reactome": "R-DDI-9706399", "name": "RHOBTB3 hydrolyzes ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10627457" ], "products": [ "species_29372", "species_10627467" ], "modifiers": [ [ "species_10627457", "catalyst" ] ], "additional_components": [ "species_113592", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "species_29370", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967", "species_113592", "P34146", "DDB_G0282365", "P34145", "DDB_G0268622", "P34149", "DDB_G0293526", "P34148", "DDB_G0279605", "Q1ZXJ6", "DDB_G0278011", "P34150", "DDB_G0291976", "Q54HZ7", "DDB_G0289103", "Q23862", "DDB_G0280975", "Q54YY4", "DDB_G0278009", "Q54N82", "DDB_G0285453", "Q9GPQ9", "DDB_G0292560", "Q9GPQ8", "DDB_G0292816", "Q9GPS0", "DDB_G0269178", "Q9GPR7", "DDB_G0269240", "P34144", "DDB_G0277869", "O96390", "DDB_G0269176", "Q9GPS3", "DDB_G0276967" ] }, "reaction_10625434": { "compartment": "compartment_70101", "id": "reaction_10625434", "reactome": "R-DDI-9018826", "name": "RHOT2 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10625411" ], "products": [ "species_29372", "species_10625413" ], "modifiers": [ [ "species_10625411", "catalyst" ] ], "additional_components": [ "Q55G45", "DDB_G0267830", "species_29438", "Q55G45", "DDB_G0267830", "species_29420", "Q55G45", "DDB_G0267830", "species_29438" ] }, "reaction_10625432": { "compartment": "compartment_70101", "id": "reaction_10625432", "reactome": "R-DDI-9018824", "name": "RHOT2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625411", "species_10625426" ], "products": [ "species_10625428" ], "modifiers": [], "additional_components": [ "Q55G45", "DDB_G0267830", "species_29438", "Q9U1M8", "DDB_G0274455", "P54696", "DDB_G0289447", "Q9TW28", "DDB_G0292262", "P54697", "DDB_G0272112", "Q9U1M8", "DDB_G0274455", "P54696", "DDB_G0289447", "Q9TW28", "DDB_G0292262", "P54697", "DDB_G0272112", "Q55G45", "DDB_G0267830", "species_29438" ] }, "reaction_10588961": { "compartment": "compartment_70101", "id": "reaction_10588961", "reactome": "R-DDI-264444", "name": "Autoubiquitination of phospho-COP1(Ser-387 )", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10588954" ], "products": [ "species_10588958" ], "modifiers": [ [ "species_10588954", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0288453", "Q54IY4", "DDB_G0288453", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0288453" ] }, "reaction_10588963": { "compartment": "compartment_70101", "id": "reaction_10588963", "reactome": "R-DDI-264458", "name": "Proteasome mediated degradation of COP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10588958" ], "products": [ "species_10577037" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q54IY4", "DDB_G0288453", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10588956": { "compartment": "compartment_13231", "id": "reaction_10588956", "reactome": "R-DDI-264418", "name": "Translocation of COP1 from the nucleus to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10588952" ], "products": [ "species_10588954" ], "modifiers": [], "additional_components": [ "DDB_G0288453", "DDB_G0288453" ] }, "reaction_10591483": { "compartment": "compartment_7660", "id": "reaction_10591483", "reactome": "R-DDI-427514", "name": "eNoSC deacetylates histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10591466", "species_427523" ], "products": [ "species_427497", "species_427498", "species_10588889" ], "modifiers": [ [ "species_10591480", "catalyst" ] ], "additional_components": [ "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863", "O15819", "DDB_G0267402", "Q54F38", "DDB_G0291185", "Q76NW2", "DDB_G0276863", "Q54CP1", "DDB_G0292960", "Q54GV7", "DDB_G0289967", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863" ] }, "reaction_10591486": { "compartment": "compartment_7660", "id": "reaction_10591486", "reactome": "R-DDI-427527", "name": "eNoSC dimethylates histone H3 at lysine-9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10588889" ], "products": [ "species_77502", "species_10581485" ], "modifiers": [ [ "species_10591480", "catalyst" ] ], "additional_components": [ "O15819", "DDB_G0267402", "Q54F38", "DDB_G0291185", "Q76NW2", "DDB_G0276863", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863", "Q54CP1", "DDB_G0292960", "Q54GV7", "DDB_G0289967", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863" ] }, "reaction_10596528": { "compartment": "compartment_70101", "id": "reaction_10596528", "reactome": "R-DDI-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10596521" ], "products": [ "species_111294", "species_10596525", "species_10596517", "species_76577" ], "modifiers": [ [ "species_10596448", "catalyst" ] ], "additional_components": [ "Q54ZG5", "DDB_G0277577", "O60999", "DDB_G0291972", "Q75JS0", "DDB_G0272202", "C7G034", "DDB_G0285063", "Q54E43", "DDB_G0291812", "Q557Q0", "DDB_G0291812", "Q55GE4", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q557G6", "DDB_G0291812", "C7G038", "DDB_G0291812", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54JE9", "DDB_G0292128", "Q54QZ3", "DDB_G0292128", "Q75JM9", "DDB_G0292128", "Q54DM4", "DDB_G0292128", "Q54JT8", "DDB_G0292128", "Q54JV0", "DDB_G0292128", "Q54IW6", "DDB_G0292128", "Q54LZ6", "DDB_G0286289", "Q55AE0", "DDB_G0285763", "Q54MZ0", "DDB_G0285763", "Q54PV3", "DDB_G0285763", "Q54TL7", "DDB_G0281679", "Q54KP2", "DDB_G0287221", "Q54GG5", "DDB_G0290179", "Q54QF1", "DDB_G0283983", "Q54XF1", "DDB_G0279003", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q553F3", "DDB_G0275787", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54ZG5", "DDB_G0277577", "O60999", "DDB_G0291972", "Q75JS0", "DDB_G0272202", "C7G034", "DDB_G0285063", "Q54E43", "DDB_G0291812", "Q557Q0", "DDB_G0291812", "Q55GE4", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q557G6", "DDB_G0291812", "C7G038", "DDB_G0291812", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54JE9", "DDB_G0292128", "Q54QZ3", "DDB_G0292128", "Q75JM9", "DDB_G0292128", "Q54DM4", "DDB_G0292128", "Q54JT8", "DDB_G0292128", "Q54JV0", "DDB_G0292128", "Q54IW6", "DDB_G0292128", "Q54LZ6", "DDB_G0286289", "Q55AE0", "DDB_G0285763", "Q54MZ0", "DDB_G0285763", "Q54PV3", "DDB_G0285763", "Q54TL7", "DDB_G0281679", "Q54KP2", "DDB_G0287221", "Q54GG5", "DDB_G0290179", "Q54QF1", "DDB_G0283983", "Q54XF1", "DDB_G0279003", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q553F3", "DDB_G0275787", "Q54ZG5", "DDB_G0277577", "O60999", "DDB_G0291972", "Q75JS0", "DDB_G0272202", "C7G034", "DDB_G0285063", "Q54E43", "DDB_G0291812", "Q557Q0", "DDB_G0291812", "Q55GE4", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q557G6", "DDB_G0291812", "C7G038", "DDB_G0291812", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54JE9", "DDB_G0292128", "Q54QZ3", "DDB_G0292128", "Q75JM9", "DDB_G0292128", "Q54DM4", "DDB_G0292128", "Q54JT8", "DDB_G0292128", "Q54JV0", "DDB_G0292128", "Q54IW6", "DDB_G0292128", "Q54LZ6", "DDB_G0286289", "Q55AE0", "DDB_G0285763", "Q54MZ0", "DDB_G0285763", "Q54PV3", "DDB_G0285763", "Q54TL7", "DDB_G0281679", "Q54KP2", "DDB_G0287221", "Q54GG5", "DDB_G0290179", "Q54QF1", "DDB_G0283983", "Q54XF1", "DDB_G0279003", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586" ] }, "reaction_10596579": { "compartment": "compartment_70101", "id": "reaction_10596579", "reactome": "R-DDI-983147", "name": "Release of E3 from polyubiquitinated substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596577" ], "products": [ "species_983123", "species_10596448" ], "modifiers": [], "additional_components": [ "Q54ZG5", "DDB_G0277577", "O60999", "DDB_G0291972", "Q75JS0", "DDB_G0272202", "C7G034", "DDB_G0285063", "Q54E43", "DDB_G0291812", "Q557Q0", "DDB_G0291812", "Q55GE4", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q557G6", "DDB_G0291812", "C7G038", "DDB_G0291812", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54JE9", "DDB_G0292128", "Q54QZ3", "DDB_G0292128", "Q75JM9", "DDB_G0292128", "Q54DM4", "DDB_G0292128", "Q54JT8", "DDB_G0292128", "Q54JV0", "DDB_G0292128", "Q54IW6", "DDB_G0292128", "Q54LZ6", "DDB_G0286289", "Q55AE0", "DDB_G0285763", "Q54MZ0", "DDB_G0285763", "Q54PV3", "DDB_G0285763", "Q54TL7", "DDB_G0281679", "Q54KP2", "DDB_G0287221", "Q54GG5", "DDB_G0290179", "Q54QF1", "DDB_G0283983", "Q54XF1", "DDB_G0279003", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54ZG5", "DDB_G0277577", "O60999", "DDB_G0291972", "Q75JS0", "DDB_G0272202", "C7G034", "DDB_G0285063", "Q54E43", "DDB_G0291812", "Q557Q0", "DDB_G0291812", "Q55GE4", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q557G6", "DDB_G0291812", "C7G038", "DDB_G0291812", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54JE9", "DDB_G0292128", "Q54QZ3", "DDB_G0292128", "Q75JM9", "DDB_G0292128", "Q54DM4", "DDB_G0292128", "Q54JT8", "DDB_G0292128", "Q54JV0", "DDB_G0292128", "Q54IW6", "DDB_G0292128", "Q54LZ6", "DDB_G0286289", "Q55AE0", "DDB_G0285763", "Q54MZ0", "DDB_G0285763", "Q54PV3", "DDB_G0285763", "Q54TL7", "DDB_G0281679", "Q54KP2", "DDB_G0287221", "Q54GG5", "DDB_G0290179", "Q54QF1", "DDB_G0283983", "Q54XF1", "DDB_G0279003", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586" ] }, "reaction_10596610": { "compartment": "compartment_70101", "id": "reaction_10596610", "reactome": "R-DDI-983152", "name": "Transfer of ubiquitin from E1 to E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596607", "species_10596517" ], "products": [ "species_10596605", "species_10596519" ], "modifiers": [ [ "species_10596517", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q553F3", "DDB_G0275787", "Q553F3", "DDB_G0275787", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q553F3", "DDB_G0275787" ] }, "reaction_10596613": { "compartment": "compartment_70101", "id": "reaction_10596613", "reactome": "R-DDI-983153", "name": "E1 mediated ubiquitin activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596605", "species_10577037", "species_113592", "species_29926" ], "products": [ "species_111294", "species_10596607", "species_29926", "species_76577" ], "modifiers": [ [ "species_10596605", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765" ] }, "reaction_10596581": { "compartment": "compartment_70101", "id": "reaction_10596581", "reactome": "R-DDI-983150", "name": "Proteasomal cleavage of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983123" ], "products": [ "species_10577037", "species_983032", "species_8942986", "species_983036" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10623191": { "compartment": "compartment_70101", "id": "reaction_10623191", "reactome": "R-DDI-8940641", "name": "THOP1 cleaves oligopeptide fragment (8-16aa)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983032" ], "products": [ "species_8955634" ], "modifiers": [ [ "species_10623188", "catalyst" ] ], "additional_components": [ "DDB_G0292362" ] }, "reaction_10596663": { "compartment": "compartment_70101", "id": "reaction_10596663", "reactome": "R-DDI-983162", "name": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983036" ], "products": [ "species_983032", "species_8942986" ], "modifiers": [ [ "species_10596660", "catalyst" ] ], "additional_components": [ "Q557I4", "DDB_G0273419", "Q55CT4", "DDB_G0270994", "Q55CY7", "DDB_G0270670" ] }, "reaction_10596616": { "compartment": "compartment_70101", "id": "reaction_10596616", "reactome": "R-DDI-983156", "name": "Polyubiquitination of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596525", "species_113592", "species_10596519" ], "products": [ "species_111294", "species_10596517", "species_76577", "species_10596577" ], "modifiers": [ [ "species_10596525", "catalyst" ] ], "additional_components": [ "Q54ZG5", "DDB_G0277577", "O60999", "DDB_G0291972", "Q75JS0", "DDB_G0272202", "C7G034", "DDB_G0285063", "Q54E43", "DDB_G0291812", "Q557Q0", "DDB_G0291812", "Q55GE4", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q557G6", "DDB_G0291812", "C7G038", "DDB_G0291812", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54JE9", "DDB_G0292128", "Q54QZ3", "DDB_G0292128", "Q75JM9", "DDB_G0292128", "Q54DM4", "DDB_G0292128", "Q54JT8", "DDB_G0292128", "Q54JV0", "DDB_G0292128", "Q54IW6", "DDB_G0292128", "Q54LZ6", "DDB_G0286289", "Q55AE0", "DDB_G0285763", "Q54MZ0", "DDB_G0285763", "Q54PV3", "DDB_G0285763", "Q54TL7", "DDB_G0281679", "Q54KP2", "DDB_G0287221", "Q54GG5", "DDB_G0290179", "Q54QF1", "DDB_G0283983", "Q54XF1", "DDB_G0279003", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q553F3", "DDB_G0275787", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q553F3", "DDB_G0275787", "Q54ZG5", "DDB_G0277577", "O60999", "DDB_G0291972", "Q75JS0", "DDB_G0272202", "C7G034", "DDB_G0285063", "Q54E43", "DDB_G0291812", "Q557Q0", "DDB_G0291812", "Q55GE4", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q557G6", "DDB_G0291812", "C7G038", "DDB_G0291812", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54JE9", "DDB_G0292128", "Q54QZ3", "DDB_G0292128", "Q75JM9", "DDB_G0292128", "Q54DM4", "DDB_G0292128", "Q54JT8", "DDB_G0292128", "Q54JV0", "DDB_G0292128", "Q54IW6", "DDB_G0292128", "Q54LZ6", "DDB_G0286289", "Q55AE0", "DDB_G0285763", "Q54MZ0", "DDB_G0285763", "Q54PV3", "DDB_G0285763", "Q54TL7", "DDB_G0281679", "Q54KP2", "DDB_G0287221", "Q54GG5", "DDB_G0290179", "Q54QF1", "DDB_G0283983", "Q54XF1", "DDB_G0279003", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54ZG5", "DDB_G0277577", "O60999", "DDB_G0291972", "Q75JS0", "DDB_G0272202", "C7G034", "DDB_G0285063", "Q54E43", "DDB_G0291812", "Q557Q0", "DDB_G0291812", "Q55GE4", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q557G6", "DDB_G0291812", "C7G038", "DDB_G0291812", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54JE9", "DDB_G0292128", "Q54QZ3", "DDB_G0292128", "Q75JM9", "DDB_G0292128", "Q54DM4", "DDB_G0292128", "Q54JT8", "DDB_G0292128", "Q54JV0", "DDB_G0292128", "Q54IW6", "DDB_G0292128", "Q54LZ6", "DDB_G0286289", "Q55AE0", "DDB_G0285763", "Q54MZ0", "DDB_G0285763", "Q54PV3", "DDB_G0285763", "Q54TL7", "DDB_G0281679", "Q54KP2", "DDB_G0287221", "Q54GG5", "DDB_G0290179", "Q54QF1", "DDB_G0283983", "Q54XF1", "DDB_G0279003", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765" ] }, "reaction_10596618": { "compartment": "compartment_70101", "id": "reaction_10596618", "reactome": "R-DDI-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596519", "species_983035", "species_10596448" ], "products": [ "species_10596521" ], "modifiers": [], "additional_components": [ "Q553F3", "DDB_G0275787", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54ZG5", "DDB_G0277577", "O60999", "DDB_G0291972", "Q75JS0", "DDB_G0272202", "C7G034", "DDB_G0285063", "Q54E43", "DDB_G0291812", "Q557Q0", "DDB_G0291812", "Q55GE4", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q557G6", "DDB_G0291812", "C7G038", "DDB_G0291812", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54JE9", "DDB_G0292128", "Q54QZ3", "DDB_G0292128", "Q75JM9", "DDB_G0292128", "Q54DM4", "DDB_G0292128", "Q54JT8", "DDB_G0292128", "Q54JV0", "DDB_G0292128", "Q54IW6", "DDB_G0292128", "Q54LZ6", "DDB_G0286289", "Q55AE0", "DDB_G0285763", "Q54MZ0", "DDB_G0285763", "Q54PV3", "DDB_G0285763", "Q54TL7", "DDB_G0281679", "Q54KP2", "DDB_G0287221", "Q54GG5", "DDB_G0290179", "Q54QF1", "DDB_G0283983", "Q54XF1", "DDB_G0279003", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54ZG5", "DDB_G0277577", "O60999", "DDB_G0291972", "Q75JS0", "DDB_G0272202", "C7G034", "DDB_G0285063", "Q54E43", "DDB_G0291812", "Q557Q0", "DDB_G0291812", "Q55GE4", "DDB_G0291812", "Q54FZ8", "DDB_G0291812", "Q557G6", "DDB_G0291812", "C7G038", "DDB_G0291812", "Q54RP0", "DDB_G0283005", "Q7KWS8", "DDB_G0276283", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "Q54UQ3", "DDB_G0280895", "Q55G05", "DDB_G0290985", "Q54FA1", "DDB_G0290985", "Q54PH6", "DDB_G0290985", "Q54F90", "DDB_G0291003", "Q54DF3", "DDB_G0292302", "Q54N86", "DDB_G0285445", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "Q54JE9", "DDB_G0292128", "Q54QZ3", "DDB_G0292128", "Q75JM9", "DDB_G0292128", "Q54DM4", "DDB_G0292128", "Q54JT8", "DDB_G0292128", "Q54JV0", "DDB_G0292128", "Q54IW6", "DDB_G0292128", "Q54LZ6", "DDB_G0286289", "Q55AE0", "DDB_G0285763", "Q54MZ0", "DDB_G0285763", "Q54PV3", "DDB_G0285763", "Q54TL7", "DDB_G0281679", "Q54KP2", "DDB_G0287221", "Q54GG5", "DDB_G0290179", "Q54QF1", "DDB_G0283983", "Q54XF1", "DDB_G0279003", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q553F3", "DDB_G0275787", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765" ] }, "reaction_10596569": { "compartment": "compartment_17957", "id": "reaction_10596569", "reactome": "R-DDI-983144", "name": "Transport of Antigen peptide in to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_983032" ], "products": [ "species_29372", "species_29370", "species_983034" ], "modifiers": [ [ "species_10596566", "catalyst" ] ], "additional_components": [ "Q54BU4", "DDB_G0293416", "Q8T9W1", "DDB_G0286123", "P54683", "DDB_G0286119", "Q23868", "DDB_G0286121" ] }, "reaction_10596648": { "compartment": "compartment_17957", "id": "reaction_10596648", "reactome": "R-DDI-983158", "name": "Trimming of peptides in ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983034" ], "products": [ "species_8943716", "species_983033" ], "modifiers": [ [ "species_10596645", "catalyst" ] ], "additional_components": [ "Q55CY7", "DDB_G0270670", "Q557I4", "DDB_G0273419", "Q55CT4", "DDB_G0270994" ] }, "reaction_10588094": { "compartment": "compartment_12045", "id": "reaction_10588094", "reactome": "R-DDI-203979", "name": "Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587919", "species_10588090" ], "products": [ "species_10588092" ], "modifiers": [], "additional_components": [ "Q559R0", "DDB_G0272296", "species_29438", "Q54T59", "DDB_G0281985", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q559R0", "DDB_G0272296", "species_29438" ] }, "reaction_10597282": { "compartment": "compartment_70101", "id": "reaction_10597282", "reactome": "R-DDI-1236970", "name": "Proteasomal clevage of exogenous antigen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1236719" ], "products": [ "species_8942986", "species_983036" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10583537": { "compartment": "compartment_876", "id": "reaction_10583537", "reactome": "R-DDI-114688", "name": "PLC-beta hydrolyses PIP2 to DAG and IP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583532" ], "products": [ "species_10583534" ], "modifiers": [ [ "species_10582955", "catalyst" ] ], "additional_components": [ "species_179856", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438", "Q02158", "DDB_G0292736", "species_6797635", "species_114520", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438", "Q02158", "DDB_G0292736", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438", "Q02158", "DDB_G0292736" ] }, "reaction_10624320": { "compartment": "compartment_876", "id": "reaction_10624320", "reactome": "R-DDI-8982026", "name": "G alpha (q):RGS dissociates to inactive G alpha (q)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624315" ], "products": [ "species_10590812", "species_10624295" ], "modifiers": [], "additional_components": [ "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29420", "species_29420", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817" ] }, "reaction_10590869": { "compartment": "compartment_876", "id": "reaction_10590869", "reactome": "R-DDI-418582", "name": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582953" ], "products": [ "species_10590812" ], "modifiers": [ [ "species_10582953", "catalyst" ], [ "species_10590867", "catalyst" ] ], "additional_components": [ "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438", "species_29420", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438", "Q55E55", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817" ] }, "reaction_10624299": { "compartment": "compartment_876", "id": "reaction_10624299", "reactome": "R-DDI-8982017", "name": "Active G alpha (q) binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582953", "species_10624295" ], "products": [ "species_10624297" ], "modifiers": [], "additional_components": [ "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438", "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438" ] }, "reaction_10583555": { "compartment": "compartment_70101", "id": "reaction_10583555", "reactome": "R-DDI-139941", "name": "Binding of IP3 to IP3 receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583548", "species_114520" ], "products": [ "species_10583550" ], "modifiers": [], "additional_components": [ "Q9NA13", "DDB_G0292564", "species_114520", "species_74112", "Q9NA13", "DDB_G0292564" ] }, "reaction_10591430": { "compartment": "compartment_876", "id": "reaction_10591430", "reactome": "R-DDI-426032", "name": "DAG is metabolized by DAGL to 2-AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114519" ], "products": [ "species_426026", "species_426030" ], "modifiers": [ [ "species_10591427", "catalyst" ] ], "additional_components": [ "Q54ET1", "DDB_G0291354", "Q54GX3", "DDB_G0291354", "Q54YL1", "DDB_G0291354" ] }, "reaction_10591452": { "compartment": "compartment_70101", "id": "reaction_10591452", "reactome": "R-DDI-426240", "name": "DAG kinase produces phosphatidic acid from DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_114519" ], "products": [ "species_76108", "species_29370" ], "modifiers": [ [ "species_10591435", "catalyst" ] ], "additional_components": [ "DDB_G0277223" ] }, "reaction_10624318": { "compartment": "compartment_876", "id": "reaction_10624318", "reactome": "R-DDI-8982025", "name": "G alpha (q) in G (q):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624297" ], "products": [ "species_29372", "species_10624315" ], "modifiers": [ [ "species_10624297", "catalyst" ] ], "additional_components": [ "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438", "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29420", "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438" ] }, "reaction_10580531": { "compartment": "compartment_70101", "id": "reaction_10580531", "reactome": "R-DDI-73616", "name": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_83960", "species_29364" ], "products": [ "species_29366", "species_73541" ], "modifiers": [ [ "species_10580469", "catalyst" ] ], "additional_components": [ "Q55FT1", "DDB_G0267966", "species_76629", "species_113596" ] }, "reaction_10580482": { "compartment": "compartment_70101", "id": "reaction_10580482", "reactome": "R-DDI-73589", "name": "5,6-dihydrouracil + H2O => beta-ureidopropionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73584" ], "products": [ "species_73588" ], "modifiers": [ [ "species_10580479", "catalyst" ] ], "additional_components": [ "species_29426", "Q55DL0", "DDB_G0269246" ] }, "reaction_10580533": { "compartment": "compartment_70101", "id": "reaction_10580533", "reactome": "R-DDI-73618", "name": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73541" ], "products": [ "species_73617" ], "modifiers": [ [ "species_10580479", "catalyst" ] ], "additional_components": [ "species_29426", "Q55DL0", "DDB_G0269246" ] }, "reaction_10580535": { "compartment": "compartment_70101", "id": "reaction_10580535", "reactome": "R-DDI-73620", "name": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73617" ], "products": [ "species_113528", "species_73619", "species_31633" ], "modifiers": [ [ "species_10580489", "catalyst" ] ], "additional_components": [ "species_29426", "Q964D8", "DDB_G0274123" ] }, "reaction_10581240": { "compartment": "compartment_70101", "id": "reaction_10581240", "reactome": "R-DDI-74376", "name": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_500430" ], "products": [ "species_83962", "species_500244" ], "modifiers": [ [ "species_10581235", "catalyst" ] ], "additional_components": [ "CHEBI:16450", "CHEBI:16704", "CHEBI:28542", "species_112016", "Q54PM8", "DDB_G0284431" ] }, "reaction_10580472": { "compartment": "compartment_70101", "id": "reaction_10580472", "reactome": "R-DDI-73585", "name": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_83962", "species_29364" ], "products": [ "species_29366", "species_73584" ], "modifiers": [ [ "species_10580469", "catalyst" ] ], "additional_components": [ "Q55FT1", "DDB_G0267966", "species_76629", "species_113596" ] }, "reaction_10580492": { "compartment": "compartment_70101", "id": "reaction_10580492", "reactome": "R-DDI-73591", "name": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73588" ], "products": [ "species_113528", "species_73590", "species_31633" ], "modifiers": [ [ "species_10580489", "catalyst" ] ], "additional_components": [ "species_29426", "Q964D8", "DDB_G0274123" ] }, "reaction_10623846": { "compartment": "compartment_5460", "id": "reaction_10623846", "reactome": "R-DDI-8952873", "name": "MECR dimer reduces tdec2-CoA to DEC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77343", "species_113529", "species_113600" ], "products": [ "species_77308", "species_113563" ], "modifiers": [ [ "species_10623843", "catalyst" ] ], "additional_components": [ "Q54YT4", "DDB_G0278095" ] }, "reaction_10582430": { "compartment": "compartment_5460", "id": "reaction_10582430", "reactome": "R-DDI-77344", "name": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77343", "species_113521" ], "products": [ "species_77341" ], "modifiers": [ [ "species_10578064", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10586368": { "compartment": "compartment_876", "id": "reaction_10586368", "reactome": "R-DDI-190519", "name": "Internalization of gap junction plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10586270", "species_10586248" ], "products": [ "species_10586366" ], "modifiers": [], "additional_components": [ "P54697", "DDB_G0272112", "Q9TW28", "DDB_G0292262", "P54696", "DDB_G0289447", "Q9U1M8", "DDB_G0274455", "P54672", "DDB_G0277139", "P54672", "DDB_G0277139", "P54696", "DDB_G0289447", "P54697", "DDB_G0272112", "Q9TW28", "DDB_G0292262", "Q9U1M8", "DDB_G0274455" ] }, "reaction_10586370": { "compartment": "compartment_70101", "id": "reaction_10586370", "reactome": "R-DDI-190829", "name": "Lysosomal degradation of gap junction plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10586366" ], "products": [], "modifiers": [], "additional_components": [ "P54672", "DDB_G0277139", "P54696", "DDB_G0289447", "P54697", "DDB_G0272112", "Q9TW28", "DDB_G0292262", "Q9U1M8", "DDB_G0274455" ] }, "reaction_10586762": { "compartment": "compartment_876", "id": "reaction_10586762", "reactome": "R-DDI-196017", "name": "Dynamin is recruited to the gap junction plaque", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10586246", "species_10586226" ], "products": [ "species_10586248" ], "modifiers": [], "additional_components": [ "P54672", "DDB_G0277139", "P54672", "DDB_G0277139" ] }, "reaction_10576483": { "compartment": "compartment_7660", "id": "reaction_10576483", "reactome": "R-DDI-68603", "name": "Orc5 associates with Orc3:Orc2:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576479", "species_10576472" ], "products": [ "species_10576481" ], "modifiers": [], "additional_components": [ "DDB_G0293214", "Q55CU7", "DDB_G0269894", "Q55BR6", "DDB_G0271078", "Q55CU7", "DDB_G0269894", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214" ] }, "reaction_10576501": { "compartment": "compartment_7660", "id": "reaction_10576501", "reactome": "R-DDI-68611", "name": "Orc1 associates with Orc4:Orc5:Orc3:Orc2:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576490", "species_10576497" ], "products": [ "species_10576499" ], "modifiers": [], "additional_components": [ "Q55CU7", "DDB_G0269894", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "Q86AD6", "DDB_G0271562", "DDB_G0283073", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "Q86AD6", "DDB_G0271562" ] }, "reaction_10576474": { "compartment": "compartment_7660", "id": "reaction_10576474", "reactome": "R-DDI-68595", "name": "Orc3 associates with Orc2 constitutively bound at origins of replication", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576463", "species_10576470" ], "products": [ "species_10576472" ], "modifiers": [], "additional_components": [ "DDB_G0271078", "Q55CU7", "DDB_G0269894", "Q55CU7", "DDB_G0269894", "Q55BR6", "DDB_G0271078" ] }, "reaction_10576492": { "compartment": "compartment_7660", "id": "reaction_10576492", "reactome": "R-DDI-68610", "name": "Orc4 associates with Orc5:Orc3:Orc2:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576488", "species_10576481" ], "products": [ "species_10576490" ], "modifiers": [], "additional_components": [ "DDB_G0271562", "Q55CU7", "DDB_G0269894", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "Q55CU7", "DDB_G0269894", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "Q86AD6", "DDB_G0271562" ] }, "reaction_10576510": { "compartment": "compartment_7660", "id": "reaction_10576510", "reactome": "R-DDI-68615", "name": "Orc6 associates with Orc1:Orc4:Orc5:Orc3:Orc2:origin complexes, forming ORC:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576506", "species_10576499" ], "products": [ "species_10576508" ], "modifiers": [], "additional_components": [ "DDB_G0284771", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "Q86AD6", "DDB_G0271562", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q86AD6", "DDB_G0271562", "Q54P62", "DDB_G0284771", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214" ] }, "reaction_10600374": { "compartment": "compartment_876", "id": "reaction_10600374", "reactome": "R-DDI-2142859", "name": "Growing HA is extruded from the cell by ABCC5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142896" ], "products": [ "species_2160848" ], "modifiers": [ [ "species_10597751", "catalyst" ] ], "additional_components": [ "species_2162224", "species_2162224", "Q54V86", "DDB_G0280539", "Q8T6H3", "DDB_G0287593", "Q54EK2", "DDB_G0291243", "Q8T6H8", "DDB_G0280541", "Q54K24", "DDB_G0287589", "Q54VC1", "DDB_G0280459", "Q54VJ0", "DDB_G0280055", "Q54NL1", "DDB_G0285165" ] }, "reaction_10611339": { "compartment": "compartment_984", "id": "reaction_10611339", "reactome": "R-DDI-5693356", "name": "CEMIP hydrolyses HA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2160848" ], "products": [ "species_5693343", "species_2160848" ], "modifiers": [ [ "species_10611336", "catalyst" ] ], "additional_components": [ "species_2162224", "species_2162224", "Q54KF6", "DDB_G0287365", "Q55D62", "DDB_G0287365" ] }, "reaction_10616531": { "compartment": "compartment_7660", "id": "reaction_10616531", "reactome": "R-DDI-6802973", "name": "PLK3 phosphorylates CDC25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10581492" ], "products": [ "species_113582", "species_10616519" ], "modifiers": [ [ "species_10616528", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "Q54BR8", "DDB_G0293470", "Q86HN7", "DDB_G0274503" ] }, "reaction_10613702": { "compartment": "compartment_70101", "id": "reaction_10613702", "reactome": "R-DDI-6798044", "name": "BTG2 binds CCR4-NOT complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613698", "species_10613634" ], "products": [ "species_10613700" ], "modifiers": [], "additional_components": [ "Q554L0", "DDB_G0275005", "Q55D59", "DDB_G0269778", "Q54HH3", "DDB_G0289461", "Q54PZ4", "DDB_G0285269", "Q54NG7", "DDB_G0285269", "Q1ZXI2", "DDB_G0279005", "Q75JL4", "DDB_G0276029", "Q54U17", "DDB_G0281363", "Q54PG2", "DDB_G0284577", "Q55AA8", "DDB_G0272056", "DDB_G0285069", "Q54NU5", "DDB_G0285069", "Q554L0", "DDB_G0275005", "Q55D59", "DDB_G0269778", "Q54HH3", "DDB_G0289461", "Q54PZ4", "DDB_G0285269", "Q54NG7", "DDB_G0285269", "Q1ZXI2", "DDB_G0279005", "Q75JL4", "DDB_G0276029", "Q54U17", "DDB_G0281363", "Q54PG2", "DDB_G0284577", "Q55AA8", "DDB_G0272056" ] }, "reaction_10616032": { "compartment": "compartment_70101", "id": "reaction_10616032", "reactome": "R-DDI-6799722", "name": "TP53I3 oxidoreductase generates unstable semiquinones", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_6799725", "species_29364" ], "products": [ "species_6799726", "species_29366" ], "modifiers": [ [ "species_10615972", "catalyst" ] ], "additional_components": [ "Q75JT6", "DDB_G0272440" ] }, "reaction_10616466": { "compartment": "compartment_876", "id": "reaction_10616466", "reactome": "R-DDI-6801101", "name": "RABGGTA binds RABGGTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616462", "species_10616457" ], "products": [ "species_10616464" ], "modifiers": [], "additional_components": [ "DDB_G0290671", "DDB_G0269570", "Q55DQ4", "DDB_G0269570", "B0G172", "DDB_G0290671" ] }, "reaction_10615974": { "compartment": "compartment_70101", "id": "reaction_10615974", "reactome": "R-DDI-6799466", "name": "TP53I3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615970" ], "products": [ "species_10615972" ], "modifiers": [], "additional_components": [ "DDB_G0272440", "Q75JT6", "DDB_G0272440" ] }, "reaction_10616475": { "compartment": "compartment_70101", "id": "reaction_10616475", "reactome": "R-DDI-6801109", "name": "CHM binds RGGT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616471", "species_10616464" ], "products": [ "species_10616473" ], "modifiers": [], "additional_components": [ "DDB_G0280143", "Q55DQ4", "DDB_G0269570", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "B0G172", "DDB_G0290671", "Q54VT9", "DDB_G0280143" ] }, "reaction_10616445": { "compartment": "compartment_70101", "id": "reaction_10616445", "reactome": "R-DDI-6800793", "name": "PIDD1 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616441" ], "products": [ "species_10616443" ], "modifiers": [], "additional_components": [ "DDB_G0284461", "DDB_G0284461" ] }, "reaction_10616491": { "compartment": "compartment_17927", "id": "reaction_10616491", "reactome": "R-DDI-6801242", "name": "TRIAP1 binds PRELID1, PRELID3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616485", "species_10616480" ], "products": [ "species_10616489" ], "modifiers": [], "additional_components": [ "DDB_G0290499", "DDB_G0287279", "Q54KL1", "DDB_G0287279", "Q54G07", "DDB_G0290499" ] }, "reaction_10616494": { "compartment": "compartment_17906", "id": "reaction_10616494", "reactome": "R-DDI-6801250", "name": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500590" ], "products": [ "species_1524101" ], "modifiers": [ [ "species_10616489", "catalyst" ] ], "additional_components": [ "Q54KL1", "DDB_G0287279", "Q54G07", "DDB_G0290499" ] }, "reaction_10613581": { "compartment": "compartment_7660", "id": "reaction_10613581", "reactome": "R-DDI-6797606", "name": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10613565" ], "products": [ "species_113582", "species_10613578" ], "modifiers": [ [ "species_10613565", "catalyst" ] ], "additional_components": [ "Q54LJ0", "DDB_G0286617", "Q75JA4", "DDB_G0271690", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q556Z2", "DDB_G0273207", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54LJ0", "DDB_G0286617", "Q75JA4", "DDB_G0271690", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q556Z2", "DDB_G0273207", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54LJ0", "DDB_G0286617", "Q75JA4", "DDB_G0271690", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q556Z2", "DDB_G0273207", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10613541": { "compartment": "compartment_70101", "id": "reaction_10613541", "reactome": "R-DDI-6795290", "name": "TORC2 complex phosphorylates SGK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613531", "species_113592" ], "products": [ "species_29370", "species_10613539" ], "modifiers": [ [ "species_10587023", "catalyst" ] ], "additional_components": [ "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54D08", "DDB_G0292592", "O77203", "DDB_G0277399", "Q9Y0C9", "DDB_G0284611", "Q86C65", "DDB_G0281569" ] }, "reaction_10613551": { "compartment": "compartment_70101", "id": "reaction_10613551", "reactome": "R-DDI-6795473", "name": "PDPK1 phosphorylates SGK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10613539" ], "products": [ "species_10613549", "species_29370" ], "modifiers": [ [ "species_10582584", "catalyst" ] ], "additional_components": [ "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "Q54TW2", "DDB_G0281471", "species_179838" ] }, "reaction_10577717": { "compartment": "compartment_70101", "id": "reaction_10577717", "reactome": "R-DDI-70377", "name": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30537", "species_29366" ], "products": [ "species_70106", "species_31467", "species_29364" ], "modifiers": [ [ "species_10577714", "catalyst" ] ], "additional_components": [ "species_29366", "Q557D2", "DDB_G0273131" ] }, "reaction_10605925": { "compartment": "compartment_70101", "id": "reaction_10605925", "reactome": "R-DDI-5631885", "name": "PRDX1 overoxidizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605917", "species_29408" ], "products": [ "species_29356", "species_10605922" ], "modifiers": [ [ "species_10605917", "catalyst" ] ], "additional_components": [ "Q555L5", "DDB_G0274859", "Q555L5", "DDB_G0274859", "Q555L5", "DDB_G0274859" ] }, "reaction_10605942": { "compartment": "compartment_70101", "id": "reaction_10605942", "reactome": "R-DDI-5631903", "name": "SESN1,2,3 bind overoxidized PRDX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605922", "species_10605938" ], "products": [ "species_10605940" ], "modifiers": [], "additional_components": [ "Q555L5", "DDB_G0274859", "Q54WU6", "DDB_G0279427", "Q54WU6", "DDB_G0279427", "Q555L5", "DDB_G0274859" ] }, "reaction_10578681": { "compartment": "compartment_70101", "id": "reaction_10578681", "reactome": "R-DDI-71682", "name": "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_111745" ], "products": [ "species_29450", "species_29366" ], "modifiers": [ [ "species_10578678", "catalyst" ] ], "additional_components": [ "Q8T137", "DDB_G0272754", "species_113596" ] }, "reaction_10589979": { "compartment": "compartment_70101", "id": "reaction_10589979", "reactome": "R-DDI-380979", "name": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584242" ], "products": [ "species_29372", "species_10589976" ], "modifiers": [ [ "species_10584242", "catalyst" ] ], "additional_components": [ "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318" ] }, "reaction_10586987": { "compartment": "compartment_70101", "id": "reaction_10586987", "reactome": "R-DDI-198609", "name": "AKT phosphorylates TSC2, inhibiting it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584141", "species_113592" ], "products": [ "species_29370", "species_10586984" ], "modifiers": [ [ "species_10586959", "catalyst" ] ], "additional_components": [ "DDB_G0280527", "DDB_G0280527", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795" ] }, "reaction_10605946": { "compartment": "compartment_70101", "id": "reaction_10605946", "reactome": "R-DDI-5631941", "name": "SESN1,2,3 bind AMPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589958", "species_10605938" ], "products": [ "species_10605944" ], "modifiers": [], "additional_components": [ "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "Q54WU6", "DDB_G0279427", "Q54WU6", "DDB_G0279427", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643" ] }, "reaction_10624930": { "compartment": "compartment_5460", "id": "reaction_10624930", "reactome": "R-DDI-9013198", "name": "TST transfers sulfur from S2O3(2-) to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614595", "species_9013199" ], "products": [ "species_9013207", "species_9013191" ], "modifiers": [ [ "species_10624637", "catalyst" ] ], "additional_components": [ "DDB_G0291816" ] }, "reaction_10617891": { "compartment": "compartment_70101", "id": "reaction_10617891", "reactome": "R-DDI-6814153", "name": "ADO oxidises 2AET to HTAU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_6814151" ], "products": [ "species_1655445", "species_70106" ], "modifiers": [ [ "species_10617888", "catalyst" ] ], "additional_components": [ "species_71067", "Q556I2", "DDB_G0273031" ] }, "reaction_10624640": { "compartment": "compartment_5460", "id": "reaction_10624640", "reactome": "R-DDI-9012721", "name": "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9012724", "species_9012592" ], "products": [ "species_1614595", "species_113557" ], "modifiers": [ [ "species_10624637", "catalyst" ] ], "additional_components": [ "DDB_G0291816" ] }, "reaction_10598498": { "compartment": "compartment_70101", "id": "reaction_10598498", "reactome": "R-DDI-1614645", "name": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_29368" ], "products": [ "species_1614519" ], "modifiers": [ [ "species_10598495", "catalyst" ] ], "additional_components": [ "species_71067", "Q54K68", "DDB_G0287555" ] }, "reaction_10624934": { "compartment": "compartment_5460", "id": "reaction_10624934", "reactome": "R-DDI-9013533", "name": "MPST transfers sulfur from sulfanegen to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9013543", "species_9013199" ], "products": [ "species_9013191", "species_113557" ], "modifiers": [ [ "species_10624637", "catalyst" ] ], "additional_components": [ "DDB_G0291816" ] }, "reaction_10624932": { "compartment": "compartment_5460", "id": "reaction_10624932", "reactome": "R-DDI-9013471", "name": "MPST transfers sulfur from 3MPYR to HCN to form HSCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9012592", "species_9013199" ], "products": [ "species_9013191", "species_113557" ], "modifiers": [ [ "species_10624637", "catalyst" ] ], "additional_components": [ "DDB_G0291816" ] }, "reaction_10598477": { "compartment": "compartment_70101", "id": "reaction_10598477", "reactome": "R-DDI-1614567", "name": "Excess homocysteine yields homolanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369" ], "products": [ "species_1614532", "species_1614594" ], "modifiers": [ [ "species_10598474", "catalyst" ], [ "species_174369", "catalyst" ] ], "additional_components": [ "Q55DV9", "DDB_G0269122" ] }, "reaction_10625805": { "compartment": "compartment_5460", "id": "reaction_10625805", "reactome": "R-DDI-9034756", "name": "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624637", "species_9012592" ], "products": [ "species_10625803", "species_113557" ], "modifiers": [ [ "species_10624637", "catalyst" ] ], "additional_components": [ "DDB_G0291816", "DDB_G0291816", "DDB_G0291816" ] }, "reaction_10625811": { "compartment": "compartment_5460", "id": "reaction_10625811", "reactome": "R-DDI-9035484", "name": "CysS248-MPST:TXN2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625807" ], "products": [ "species_10624637", "species_10602636", "species_1655881" ], "modifiers": [], "additional_components": [ "Q54NX3", "DDB_G0284939", "Q54E40", "DDB_G0291816", "DDB_G0291816", "DDB_G0284939" ] }, "reaction_10598483": { "compartment": "compartment_70101", "id": "reaction_10598483", "reactome": "R-DDI-1614591", "name": "Excess cysteine yields lanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707" ], "products": [ "species_1614582", "species_1614532" ], "modifiers": [ [ "species_10598474", "catalyst" ], [ "species_111707", "catalyst" ] ], "additional_components": [ "Q55DV9", "DDB_G0269122" ] }, "reaction_10625809": { "compartment": "compartment_5460", "id": "reaction_10625809", "reactome": "R-DDI-9035227", "name": "TXN2 binds CysS248-MPST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625803", "species_10602633" ], "products": [ "species_10625807" ], "modifiers": [], "additional_components": [ "DDB_G0291816", "DDB_G0284939", "Q54NX3", "DDB_G0284939", "Q54E40", "DDB_G0291816" ] }, "reaction_10598485": { "compartment": "compartment_70101", "id": "reaction_10598485", "reactome": "R-DDI-1614614", "name": "Cysteine is degraded to serine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111707" ], "products": [ "species_1614532", "species_200736" ], "modifiers": [ [ "species_10598474", "catalyst" ] ], "additional_components": [ "Q55DV9", "DDB_G0269122" ] }, "reaction_10598488": { "compartment": "compartment_70101", "id": "reaction_10598488", "reactome": "R-DDI-1614631", "name": "Homocysteine is degraded to oxobutanoate and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_174369" ], "products": [ "species_1614532", "species_29382", "species_936714" ], "modifiers": [ [ "species_10598474", "catalyst" ] ], "additional_components": [ "Q55DV9", "DDB_G0269122" ] }, "reaction_10598464": { "compartment": "compartment_5460", "id": "reaction_10598464", "reactome": "R-DDI-1614544", "name": "Sulfite is oxidized to sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_1614538", "species_113521" ], "products": [ "species_1614617", "species_1614584" ], "modifiers": [ [ "species_10598461", "catalyst" ] ], "additional_components": [ "Q54XJ8", "DDB_G0278893", "species_947539" ] }, "reaction_10598466": { "compartment": "compartment_70616", "id": "reaction_10598466", "reactome": "R-DDI-1614546", "name": "Sulfate is exported to the cytosol in exchange for dicarboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198498", "species_1614584" ], "products": [ "species_113544", "species_174375" ], "modifiers": [ [ "species_10589601", "catalyst" ] ], "additional_components": [ "DDB_G0284225" ] }, "reaction_10599916": { "compartment": "compartment_70101", "id": "reaction_10599916", "reactome": "R-DDI-2028626", "name": "Phosphorylated MOB1A proteins associate with LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599890", "species_10599858" ], "products": [ "species_10599892" ], "modifiers": [], "additional_components": [ "Q54BM4", "DDB_G0293706", "Q54CR8", "DDB_G0292758", "Q54XJ0", "DDB_G0278907", "Q54QV0", "DDB_G0283625", "Q1ZXI5", "DDB_G0278845", "Q54HD2", "DDB_G0289543", "Q54P47", "DDB_G0284839", "Q1ZXI5", "DDB_G0278845", "Q54HD2", "DDB_G0289543", "Q54P47", "DDB_G0284839", "Q54BM4", "DDB_G0293706", "Q54CR8", "DDB_G0292758", "Q54XJ0", "DDB_G0278907", "Q54QV0", "DDB_G0283625" ] }, "reaction_10624545": { "compartment": "compartment_5460", "id": "reaction_10624545", "reactome": "R-DDI-9011595", "name": "GSTZ1 dimer dehalogenates DCA to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9010792", "species_113521" ], "products": [ "species_904849", "species_3301973" ], "modifiers": [ [ "species_10624542", "catalyst" ], [ "species_1655887", "catalyst" ], [ "species_9010792", "inhibitor" ] ], "additional_components": [ "species_29450", "Q54YN2", "DDB_G0278155" ] }, "reaction_10583891": { "compartment": "compartment_12045", "id": "reaction_10583891", "reactome": "R-DDI-162721", "name": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449299" ], "products": [ "species_29420", "species_162681" ], "modifiers": [ [ "species_10583888", "catalyst" ] ], "additional_components": [ "Q54LP3", "DDB_G0286519", "Q556K9", "DDB_G0272588", "Q76NT6", "DDB_G0277435" ] }, "reaction_10611745": { "compartment": "compartment_13959", "id": "reaction_10611745", "reactome": "R-DDI-5694439", "name": "COPII coat binds TRAPPCII and RAB1:GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10588070", "species_10611620", "species_10611571" ], "products": [ "species_10611622" ], "modifiers": [], "additional_components": [ "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q559Q3", "DDB_G0272298", "Q54J84", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54VR1", "DDB_G0288221", "Q8T2J5", "DDB_G0271968", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q55CT5", "DDB_G0270992", "Q54DS8", "DDB_G0292052", "Q54EA5", "DDB_G0291694", "Q55CR0", "DDB_G0269942", "Q54UU1", "DDB_G0280827", "Q54TK7", "DDB_G0281693", "Q54RV6", "DDB_G0282887", "Q54CU7", "DDB_G0292690", "Q54YG5", "DDB_G0278643", "Q557G3", "DDB_G0273467", "Q555X3", "DDB_G0274803", "Q556Z3", "DDB_G0273209", "Q86K94", "DDB_G0277135", "P34139", "DDB_G0283757", "species_29420", "P34139", "DDB_G0283757", "species_29420", "Q54UU1", "DDB_G0280827", "Q54TK7", "DDB_G0281693", "Q54RV6", "DDB_G0282887", "Q54CU7", "DDB_G0292690", "Q54YG5", "DDB_G0278643", "Q557G3", "DDB_G0273467", "Q555X3", "DDB_G0274803", "Q556Z3", "DDB_G0273209", "Q86K94", "DDB_G0277135", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q559Q3", "DDB_G0272298", "Q54J84", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54VR1", "DDB_G0288221", "Q8T2J5", "DDB_G0271968", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q55CT5", "DDB_G0270992", "Q54DS8", "DDB_G0292052", "Q54EA5", "DDB_G0291694", "Q55CR0", "DDB_G0269942" ] }, "reaction_10588096": { "compartment": "compartment_12045", "id": "reaction_10588096", "reactome": "R-DDI-204008", "name": "SEC31:SEC13 and v-SNARE recruitment", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587867", "species_10587880", "species_10588000" ], "products": [ "species_10588002" ], "modifiers": [], "additional_components": [ "Q54DS8", "DDB_G0292052", "Q55CT5", "DDB_G0270992", "Q54EA5", "DDB_G0291694", "Q55CR0", "DDB_G0269942", "Q55BR0", "DDB_G0269198", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54J84", "DDB_G0288221", "Q559Q3", "DDB_G0272298", "Q559R0", "DDB_G0272296", "species_29438", "Q55BR0", "DDB_G0269198", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54J84", "DDB_G0288221", "Q559Q3", "DDB_G0272298", "Q559R0", "DDB_G0272296", "species_29438", "Q55CR0", "DDB_G0269942", "Q54DS8", "DDB_G0292052", "Q55CT5", "DDB_G0270992", "Q54EA5", "DDB_G0291694" ] }, "reaction_10588082": { "compartment": "compartment_70101", "id": "reaction_10588082", "reactome": "R-DDI-203977", "name": "SAR1 Activation And Membrane Binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10588074" ], "products": [ "species_10587919", "species_29420" ], "modifiers": [ [ "species_10588079", "catalyst" ] ], "additional_components": [ "Q559R0", "DDB_G0272296", "species_29420", "Q559R0", "DDB_G0272296", "species_29438", "DDB_G0286167" ] }, "reaction_10611842": { "compartment": "compartment_70101", "id": "reaction_10611842", "reactome": "R-DDI-5694527", "name": "Loss of SAR1B GTPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587994" ], "products": [ "species_29372", "species_10588090", "species_10588074", "species_10587992" ], "modifiers": [ [ "species_10587994", "catalyst" ] ], "additional_components": [ "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54J84", "DDB_G0288221", "Q559Q3", "DDB_G0272298", "Q559R0", "DDB_G0272296", "species_29438", "Q54T59", "DDB_G0281985", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q559R0", "DDB_G0272296", "species_29420", "Q54T59", "DDB_G0281985", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q54Z72", "DDB_G0277797", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54J84", "DDB_G0288221", "Q559Q3", "DDB_G0272298", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54J84", "DDB_G0288221", "Q559Q3", "DDB_G0272298", "Q559R0", "DDB_G0272296", "species_29438" ] }, "reaction_10618326": { "compartment": "compartment_6791047", "id": "reaction_10618326", "reactome": "R-DDI-6814831", "name": "TBC1D20 binds RAB1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611792", "species_10618322" ], "products": [ "species_10618324" ], "modifiers": [], "additional_components": [ "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "DDB_G0283055", "Q54RT5", "DDB_G0283055", "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736" ] }, "reaction_10611687": { "compartment": "compartment_70101", "id": "reaction_10611687", "reactome": "R-DDI-5694421", "name": "PP6 dephosphorylates SEC24", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10611666" ], "products": [ "species_29372", "species_10588088" ], "modifiers": [ [ "species_10611684", "catalyst" ] ], "additional_components": [ "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q55FM2", "DDB_G0268044", "Q54J43", "DDB_G0288307", "Q9U9A3", "DDB_G0272118" ] }, "reaction_10611800": { "compartment": "compartment_6791047", "id": "reaction_10611800", "reactome": "R-DDI-5694441", "name": "CSNK1D phosphorylates SEC23", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10611760" ], "products": [ "species_29370", "species_10587867", "species_10611766", "species_10611620", "species_10611764", "species_10611666", "species_10611792" ], "modifiers": [ [ "species_10611797", "catalyst" ] ], "additional_components": [ "Q54C46", "DDB_G0293248", "Q54UU1", "DDB_G0280827", "Q54TK7", "DDB_G0281693", "Q54RV6", "DDB_G0282887", "Q54CU7", "DDB_G0292690", "Q54YG5", "DDB_G0278643", "Q557G3", "DDB_G0273467", "Q555X3", "DDB_G0274803", "Q556Z3", "DDB_G0273209", "Q86K94", "DDB_G0277135", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q559Q3", "DDB_G0272298", "Q54J84", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54VR1", "DDB_G0288221", "Q8T2J5", "DDB_G0271968", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q55CT5", "DDB_G0270992", "Q54DS8", "DDB_G0292052", "Q54EA5", "DDB_G0291694", "Q55CR0", "DDB_G0269942", "P34139", "DDB_G0283757", "species_29438", "Q553R1", "DDB_G0275331", "Q54DS8", "DDB_G0292052", "Q55CT5", "DDB_G0270992", "Q54EA5", "DDB_G0291694", "Q559Q3", "DDB_G0272298", "Q54J84", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54VR1", "DDB_G0288221", "Q8T2J5", "DDB_G0271968", "Q54T59", "DDB_G0281985", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q54Z72", "DDB_G0277797", "Q54C46", "DDB_G0293248", "Q553R1", "DDB_G0275331", "Q55CR0", "DDB_G0269942", "Q54UU1", "DDB_G0280827", "Q54TK7", "DDB_G0281693", "Q54RV6", "DDB_G0282887", "Q54CU7", "DDB_G0292690", "Q54YG5", "DDB_G0278643", "Q557G3", "DDB_G0273467", "Q555X3", "DDB_G0274803", "Q556Z3", "DDB_G0273209", "Q86K94", "DDB_G0277135", "DDB_G0281985", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "DDB_G0273059" ] }, "reaction_10611738": { "compartment": "compartment_6791047", "id": "reaction_10611738", "reactome": "R-DDI-5694423", "name": "NSF and SNAPs bind cis-SNARE complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611694", "species_10611734", "species_10611703" ], "products": [ "species_10611736" ], "modifiers": [], "additional_components": [ "Q75JI3", "DDB_G0276153", "Q55CR0", "DDB_G0269942", "Q54IJ1", "DDB_G0288719", "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q55FD0", "DDB_G0268452", "Q54NP6", "DDB_G0285111", "Q54NP6", "DDB_G0285111", "Q55CR0", "DDB_G0269942", "Q54IJ1", "DDB_G0288719", "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q55FD0", "DDB_G0268452", "Q75JI3", "DDB_G0276153" ] }, "reaction_10618329": { "compartment": "compartment_6791047", "id": "reaction_10618329", "reactome": "R-DDI-6814833", "name": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618324" ], "products": [ "species_10611571", "species_10618322" ], "modifiers": [ [ "species_10618324", "catalyst" ] ], "additional_components": [ "Q54RT5", "DDB_G0283055", "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "P34139", "DDB_G0283757", "species_29420", "DDB_G0283055", "Q54RT5", "DDB_G0283055", "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736" ] }, "reaction_10611629": { "compartment": "compartment_13959", "id": "reaction_10611629", "reactome": "R-DDI-5694409", "name": "Nucleotide exchange on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10611622" ], "products": [ "species_29420", "species_10611626" ], "modifiers": [ [ "species_10611622", "catalyst" ] ], "additional_components": [ "P34139", "DDB_G0283757", "species_29420", "Q54UU1", "DDB_G0280827", "Q54TK7", "DDB_G0281693", "Q54RV6", "DDB_G0282887", "Q54CU7", "DDB_G0292690", "Q54YG5", "DDB_G0278643", "Q557G3", "DDB_G0273467", "Q555X3", "DDB_G0274803", "Q556Z3", "DDB_G0273209", "Q86K94", "DDB_G0277135", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q559Q3", "DDB_G0272298", "Q54J84", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54VR1", "DDB_G0288221", "Q8T2J5", "DDB_G0271968", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q55CT5", "DDB_G0270992", "Q54DS8", "DDB_G0292052", "Q54EA5", "DDB_G0291694", "Q55CR0", "DDB_G0269942", "Q54UU1", "DDB_G0280827", "Q54TK7", "DDB_G0281693", "Q54RV6", "DDB_G0282887", "Q54CU7", "DDB_G0292690", "Q54YG5", "DDB_G0278643", "Q557G3", "DDB_G0273467", "Q555X3", "DDB_G0274803", "Q556Z3", "DDB_G0273209", "Q86K94", "DDB_G0277135", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q559Q3", "DDB_G0272298", "Q54J84", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54VR1", "DDB_G0288221", "Q8T2J5", "DDB_G0271968", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q55CT5", "DDB_G0270992", "Q54DS8", "DDB_G0292052", "Q54EA5", "DDB_G0291694", "Q55CR0", "DDB_G0269942", "P34139", "DDB_G0283757", "species_29438", "P34139", "DDB_G0283757", "species_29420", "Q54UU1", "DDB_G0280827", "Q54TK7", "DDB_G0281693", "Q54RV6", "DDB_G0282887", "Q54CU7", "DDB_G0292690", "Q54YG5", "DDB_G0278643", "Q557G3", "DDB_G0273467", "Q555X3", "DDB_G0274803", "Q556Z3", "DDB_G0273209", "Q86K94", "DDB_G0277135", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q559Q3", "DDB_G0272298", "Q54J84", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54VR1", "DDB_G0288221", "Q8T2J5", "DDB_G0271968", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q55CT5", "DDB_G0270992", "Q54DS8", "DDB_G0292052", "Q54EA5", "DDB_G0291694", "Q55CR0", "DDB_G0269942" ] }, "reaction_10611741": { "compartment": "compartment_6791047", "id": "reaction_10611741", "reactome": "R-DDI-5694425", "name": "NSF ATPase activity dissociates cis-SNARE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10611736" ], "products": [ "species_10611694", "species_10611710", "species_10611724", "species_10611708", "species_29372", "species_10611703", "species_10611732", "species_10611715" ], "modifiers": [ [ "species_10611736", "catalyst" ] ], "additional_components": [ "Q54NP6", "DDB_G0285111", "Q55CR0", "DDB_G0269942", "Q54IJ1", "DDB_G0288719", "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q55FD0", "DDB_G0268452", "Q75JI3", "DDB_G0276153", "Q75JI3", "DDB_G0276153", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "DDB_G0282433", "Q54NP6", "DDB_G0285111", "Q55CR0", "DDB_G0269942", "DDB_G0288719", "Q54NP6", "DDB_G0285111", "Q55CR0", "DDB_G0269942", "Q54IJ1", "DDB_G0288719", "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q55FD0", "DDB_G0268452", "Q75JI3", "DDB_G0276153" ] }, "reaction_10611839": { "compartment": "compartment_12045", "id": "reaction_10611839", "reactome": "R-DDI-5694522", "name": "Inner coat assembly and cargo binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587919", "species_10588090", "species_10587992" ], "products": [ "species_10587994" ], "modifiers": [], "additional_components": [ "Q559R0", "DDB_G0272296", "species_29438", "Q54T59", "DDB_G0281985", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q54Z72", "DDB_G0277797", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54J84", "DDB_G0288221", "Q559Q3", "DDB_G0272298", "Q54U61", "DDB_G0281255", "Q54Z72", "DDB_G0277797", "Q54T59", "DDB_G0281985", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54J84", "DDB_G0288221", "Q559Q3", "DDB_G0272298", "Q559R0", "DDB_G0272296", "species_29438" ] }, "reaction_10617088": { "compartment": "compartment_432051", "id": "reaction_10617088", "reactome": "R-DDI-6809003", "name": "ERGIC-to-Golgi vesicles bind dynein:dynactin ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617084", "species_10605683" ], "products": [ "species_10617086" ], "modifiers": [], "additional_components": [ "Q54BK5", "DDB_G0293712", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "Q558I0", "DDB_G0272905", "P34141", "DDB_G0291233", "P34140", "DDB_G0277867", "Q54EW9", "DDB_G0291293", "P34143", "DDB_G0271736", "Q552K3", "DDB_G0275969", "Q54NU2", "DDB_G0284985", "species_29438", "Q553R1", "DDB_G0275331", "Q54HL0", "DDB_G0289371", "Q23924", "DDB_G0284735", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "Q54HD4", "DDB_G0289523", "Q55FR9", "DDB_G0267982", "Q55FU2", "DDB_G0267950", "Q54YD8", "DDB_G0278285", "Q769F6", "DDB_G0277923", "Q769F9", "DDB_G0288053", "Q54BN0", "DDB_G0293540", "Q769F7", "DDB_G0278969", "Q86JE5", "DDB_G0272124", "Q54SJ2", "DDB_G0282433", "Q54V78", "DDB_G0280565", "P05095", "DDB_G0268632", "Q550R2", "DDB_G0276893", "P54703", "DDB_G0280849", "Q86A88", "DDB_G0274815", "Q54CI8", "DDB_G0292904", "P34036", "DDB_G0276355", "Q54VD6", "DDB_G0280435", "Q54ZI7", "DDB_G0277561", "Q54N50", "DDB_G0285503", "P13021", "DDB_G0267374", "P13022", "DDB_G0272104", "Q54JY2", "DDB_G0287739", "Q54FM4", "DDB_G0290757", "Q54VS0", "DDB_G0280175", "Q54XU5", "DDB_G0278579", "Q54I79", "DDB_G0288937", "species_29438", "species_29420", "P54703", "DDB_G0280849", "Q86A88", "DDB_G0274815", "Q54CI8", "DDB_G0292904", "P34036", "DDB_G0276355", "Q54VD6", "DDB_G0280435", "Q54ZI7", "DDB_G0277561", "Q54N50", "DDB_G0285503", "P13021", "DDB_G0267374", "P13022", "DDB_G0272104", "Q54JY2", "DDB_G0287739", "Q54FM4", "DDB_G0290757", "Q54VS0", "DDB_G0280175", "Q54XU5", "DDB_G0278579", "Q54I79", "DDB_G0288937", "species_29438", "species_29420", "Q54BK5", "DDB_G0293712", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "Q558I0", "DDB_G0272905", "P34141", "DDB_G0291233", "P34140", "DDB_G0277867", "Q54EW9", "DDB_G0291293", "P34143", "DDB_G0271736", "Q552K3", "DDB_G0275969", "Q54NU2", "DDB_G0284985", "Q553R1", "DDB_G0275331", "Q54HL0", "DDB_G0289371", "Q23924", "DDB_G0284735", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "Q54HD4", "DDB_G0289523", "Q55FR9", "DDB_G0267982", "Q55FU2", "DDB_G0267950", "Q54YD8", "DDB_G0278285", "Q769F6", "DDB_G0277923", "Q769F9", "DDB_G0288053", "Q54BN0", "DDB_G0293540", "Q769F7", "DDB_G0278969", "Q86JE5", "DDB_G0272124", "Q54SJ2", "DDB_G0282433", "Q54V78", "DDB_G0280565", "P05095", "DDB_G0268632", "Q550R2", "DDB_G0276893" ] }, "reaction_10617281": { "compartment": "compartment_20699", "id": "reaction_10617281", "reactome": "R-DDI-6809015", "name": "NSF ATPase activity dissociates cis-SNARE at cis-Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617276", "species_113592" ], "products": [ "species_29372", "species_10617262", "species_10617256", "species_10617258", "species_10617237", "species_10617143", "species_10617254" ], "modifiers": [ [ "species_10617276", "catalyst" ] ], "additional_components": [ "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712", "Q54QH2", "DDB_G0283831", "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q55FD0", "DDB_G0268452", "Q75JI3", "DDB_G0276153", "DDB_G0268452", "DDB_G0282433", "DDB_G0277565", "DDB_G0282433", "DDB_G0293712", "DDB_G0283831", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712", "Q54QH2", "DDB_G0283831", "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q55FD0", "DDB_G0268452", "Q75JI3", "DDB_G0276153" ] }, "reaction_10616792": { "compartment": "compartment_6791047", "id": "reaction_10616792", "reactome": "R-DDI-6807868", "name": "GBF1 stimulates ARF nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10616785" ], "products": [ "species_29370", "species_10616789" ], "modifiers": [ [ "species_10616785", "catalyst" ] ], "additional_components": [ "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q553R1", "DDB_G0275331", "species_29420", "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q553R1", "DDB_G0275331", "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q553R1", "DDB_G0275331", "species_29420" ] }, "reaction_10616779": { "compartment": "compartment_6791047", "id": "reaction_10616779", "reactome": "R-DDI-6807864", "name": "RAB1:GTP recruits GBF1 to the ERGIC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616775", "species_10616771", "species_10611792" ], "products": [ "species_10616777" ], "modifiers": [], "additional_components": [ "Q553R1", "DDB_G0275331", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q553R1", "DDB_G0275331" ] }, "reaction_10617272": { "compartment": "compartment_20699", "id": "reaction_10617272", "reactome": "R-DDI-6809011", "name": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617268", "species_10617249" ], "products": [ "species_10617270" ], "modifiers": [], "additional_components": [ "Q54QH2", "DDB_G0283831", "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q55FD0", "DDB_G0268452", "Q54C46", "DDB_G0293248", "Q54YV5", "DDB_G0278061", "Q54LC8", "DDB_G0286705", "Q54C87", "DDB_G0293106", "Q54ZB3", "DDB_G0277691", "Q54UC2", "DDB_G0281163", "Q55BB8", "DDB_G0271388", "Q54HE0", "DDB_G0289535", "Q54CT0", "DDB_G0292784", "Q54TT4", "DDB_G0281511", "Q769F9", "DDB_G0288053", "Q54BN0", "DDB_G0293540", "Q769F6", "DDB_G0277923", "Q769F7", "DDB_G0278969", "Q54BK5", "DDB_G0293712", "Q55FU2", "DDB_G0267950", "Q54YD8", "DDB_G0278285", "Q55FR9", "DDB_G0267982", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "Q54HD4", "DDB_G0289523", "Q54HL0", "DDB_G0289371", "Q23924", "DDB_G0284735", "Q553R1", "DDB_G0275331", "species_29438", "Q552K3", "DDB_G0275969", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "Q558I0", "DDB_G0272905", "P34141", "DDB_G0291233", "P34140", "DDB_G0277867", "Q54EW9", "DDB_G0291293", "P34143", "DDB_G0271736", "Q86JE5", "DDB_G0272124", "Q54SJ2", "DDB_G0282433", "Q54V78", "DDB_G0280565", "P05095", "DDB_G0268632", "Q550R2", "DDB_G0276893", "Q54C46", "DDB_G0293248", "Q54YV5", "DDB_G0278061", "Q54LC8", "DDB_G0286705", "Q54C87", "DDB_G0293106", "Q54ZB3", "DDB_G0277691", "Q54UC2", "DDB_G0281163", "Q55BB8", "DDB_G0271388", "Q54HE0", "DDB_G0289535", "Q54CT0", "DDB_G0292784", "Q54TT4", "DDB_G0281511", "Q769F9", "DDB_G0288053", "Q54BN0", "DDB_G0293540", "Q769F6", "DDB_G0277923", "Q769F7", "DDB_G0278969", "Q54BK5", "DDB_G0293712", "Q55FU2", "DDB_G0267950", "Q54YD8", "DDB_G0278285", "Q55FR9", "DDB_G0267982", "Q55EZ6", "DDB_G0268702", "Q54CA7", "DDB_G0293086", "Q54HD4", "DDB_G0289523", "Q54HL0", "DDB_G0289371", "Q23924", "DDB_G0284735", "Q553R1", "DDB_G0275331", "species_29438", "Q552K3", "DDB_G0275969", "Q54NU2", "DDB_G0284985", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "Q558I0", "DDB_G0272905", "P34141", "DDB_G0291233", "P34140", "DDB_G0277867", "Q54EW9", "DDB_G0291293", "P34143", "DDB_G0271736", "Q86JE5", "DDB_G0272124", "Q54SJ2", "DDB_G0282433", "Q54V78", "DDB_G0280565", "P05095", "DDB_G0268632", "Q550R2", "DDB_G0276893", "Q54QH2", "DDB_G0283831", "Q54ZH1", "DDB_G0277565", "Q55FD0", "DDB_G0268452" ] }, "reaction_10617278": { "compartment": "compartment_20699", "id": "reaction_10617278", "reactome": "R-DDI-6809014", "name": "cis-Golgi cis-SNARE binds NSF and SNAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611694", "species_10617274", "species_10611703" ], "products": [ "species_10617276" ], "modifiers": [], "additional_components": [ "Q75JI3", "DDB_G0276153", "Q54BK5", "DDB_G0293712", "Q54QH2", "DDB_G0283831", "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q55FD0", "DDB_G0268452", "Q54NP6", "DDB_G0285111", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712", "Q54QH2", "DDB_G0283831", "Q54SJ2", "DDB_G0282433", "Q54ZH1", "DDB_G0277565", "Q55FD0", "DDB_G0268452", "Q75JI3", "DDB_G0276153" ] }, "reaction_10616847": { "compartment": "compartment_6791047", "id": "reaction_10616847", "reactome": "R-DDI-6807872", "name": "Active ARF recruits coatomer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616843", "species_10616789" ], "products": [ "species_10616845" ], "modifiers": [], "additional_components": [ "Q55EZ6", "DDB_G0268702", "Q23924", "DDB_G0284735", "Q54HL0", "DDB_G0289371", "Q54CA7", "DDB_G0293086", "Q54HD4", "DDB_G0289523", "Q54YD8", "DDB_G0278285", "Q55FU2", "DDB_G0267950", "Q55FR9", "DDB_G0267982", "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q553R1", "DDB_G0275331", "species_29438", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "P34139", "DDB_G0283757", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q553R1", "DDB_G0275331", "Q55EZ6", "DDB_G0268702", "Q23924", "DDB_G0284735", "Q54HL0", "DDB_G0289371", "Q54CA7", "DDB_G0293086", "Q54HD4", "DDB_G0289523", "Q54YD8", "DDB_G0278285", "Q55FU2", "DDB_G0267950", "Q55FR9", "DDB_G0267982" ] }, "reaction_10611650": { "compartment": "compartment_12045", "id": "reaction_10611650", "reactome": "R-DDI-5694413", "name": "SEC4C,D bind GOSR2 and STX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587933", "species_10587931", "species_10587937" ], "products": [ "species_10587939" ], "modifiers": [], "additional_components": [ "DDB_G0277797", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "DDB_G0281985", "Q54T59", "DDB_G0281985", "Q55FD0", "DDB_G0268452", "Q54ZH1", "DDB_G0277565", "Q54Z72", "DDB_G0277797" ] }, "reaction_10611654": { "compartment": "compartment_12045", "id": "reaction_10611654", "reactome": "R-DDI-5694415", "name": "SEC24A,B:SEC23A bind SEC22B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10588084", "species_10587872", "species_10587937" ], "products": [ "species_10611652" ], "modifiers": [], "additional_components": [ "DDB_G0281255", "DDB_G0269942", "DDB_G0281985", "Q55CR0", "DDB_G0269942", "Q54U61", "DDB_G0281255", "Q54T59", "DDB_G0281985" ] }, "reaction_10611743": { "compartment": "compartment_12045", "id": "reaction_10611743", "reactome": "R-DDI-5694428", "name": "LMAN family proteins bind glycosylated cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587988", "species_10587954" ], "products": [ "species_10587990" ], "modifiers": [], "additional_components": [ "Q54VR1", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54J84", "DDB_G0288221", "Q559Q3", "DDB_G0272298", "Q8T2J5", "DDB_G0271968", "Q8T2J5", "DDB_G0271968", "Q54VR1", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54J84", "DDB_G0288221", "Q559Q3", "DDB_G0272298" ] }, "reaction_10626054": { "compartment": "compartment_876", "id": "reaction_10626054", "reactome": "R-DDI-9606884", "name": "PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_113592", "species_10626042" ], "products": [ "species_29370", "species_10626052" ], "modifiers": [], "additional_components": [ "Q54CE1", "DDB_G0293166", "Q54U56", "DDB_G0293166", "Q54U56", "DDB_G0293166", "Q54CE1", "DDB_G0293166", "species_179838" ] }, "reaction_10597136": { "compartment": "compartment_876", "id": "reaction_10597136", "reactome": "R-DDI-1168636", "name": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10585874" ], "products": [ "species_29420", "species_10585144" ], "modifiers": [ [ "species_10597133", "catalyst" ] ], "additional_components": [ "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29420", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "species_6797635", "Q8IS15", "DDB_G0277915", "Q8IS16", "DDB_G0276963", "B0M0P8", "DDB_G0276371", "Q54C94", "DDB_G0293006", "Q8IS20", "DDB_G0282381", "Q8IS21", "DDB_G0269222", "Q54FF3", "DDB_G0290901", "Q54H95", "DDB_G0289613", "Q8SSQ0", "DDB_G0274605", "Q8SSW7", "DDB_G0271868", "Q54PQ4", "DDB_G0284329", "Q54XL4", "DDB_G0289613", "Q8ST25", "DDB_G0272032", "Q55FD8", "DDB_G0268578", "Q55GH9", "DDB_G0267666", "Q8IS11", "DDB_G0290267", "Q8IS14", "DDB_G0277913" ] }, "reaction_10627377": { "compartment": "compartment_70101", "id": "reaction_10627377", "reactome": "R-DDI-9690461", "name": "FKBP1A binds tacrolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584268", "species_9678991" ], "products": [ "species_10627375" ], "modifiers": [], "additional_components": [ "DDB_G0280877", "Q54UR2", "DDB_G0280877" ] }, "reaction_10622977": { "compartment": "compartment_7660", "id": "reaction_10622977", "reactome": "R-DDI-8937022", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10622972" ], "products": [ "species_77502", "species_10622974" ], "modifiers": [ [ "species_10622972", "catalyst" ] ], "additional_components": [ "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863", "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "O15819", "DDB_G0267402", "Q54F38", "DDB_G0291185", "Q76NW2", "DDB_G0276863", "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863" ] }, "reaction_10622950": { "compartment": "compartment_7660", "id": "reaction_10622950", "reactome": "R-DDI-8936608", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10622945" ], "products": [ "species_77502", "species_10622947" ], "modifiers": [ [ "species_10622945", "catalyst" ] ], "additional_components": [ "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863", "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "O15819", "DDB_G0267402", "Q54F38", "DDB_G0291185", "Q76NW2", "DDB_G0276863", "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863" ] }, "reaction_10622986": { "compartment": "compartment_7660", "id": "reaction_10622986", "reactome": "R-DDI-8937113", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10622981" ], "products": [ "species_77502", "species_10622983" ], "modifiers": [ [ "species_10622981", "catalyst" ] ], "additional_components": [ "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863", "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "O15819", "DDB_G0267402", "Q54F38", "DDB_G0291185", "Q76NW2", "DDB_G0276863", "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863" ] }, "reaction_10622941": { "compartment": "compartment_7660", "id": "reaction_10622941", "reactome": "R-DDI-8936584", "name": "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10622927" ], "products": [ "species_77502", "species_10622938" ], "modifiers": [ [ "species_10622927", "catalyst" ] ], "additional_components": [ "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863", "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "O15819", "DDB_G0267402", "Q54F38", "DDB_G0291185", "Q76NW2", "DDB_G0276863", "Q55FN5", "DDB_G0268024", "Q54HI0", "DDB_G0289445", "Q54UJ3", "DDB_G0281045", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863" ] }, "reaction_10583367": { "compartment": "compartment_17906", "id": "reaction_10583367", "reactome": "R-DDI-114284", "name": "Release of Cytochrome c from mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583365" ], "products": [ "species_10583363" ], "modifiers": [], "additional_components": [ "DDB_G0275537", "DDB_G0275537" ] }, "reaction_10582546": { "compartment": "compartment_7660", "id": "reaction_10582546", "reactome": "R-DDI-109636", "name": "Recognition and Binding of Core Promoter Elements by TFIID", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580910", "species_109627" ], "products": [ "species_10581548" ], "modifiers": [], "additional_components": [ "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617" ] }, "reaction_10582548": { "compartment": "compartment_7660", "id": "reaction_10582548", "reactome": "R-DDI-109637", "name": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580844", "species_10581548", "species_10580839" ], "products": [ "species_10581550" ], "modifiers": [], "additional_components": [ "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54FD6", "DDB_G0290929" ] }, "reaction_10581556": { "compartment": "compartment_7660", "id": "reaction_10581556", "reactome": "R-DDI-75095", "name": "Binding of TFIIE to the growing preinitiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580922", "species_10581552" ], "products": [ "species_10581554" ], "modifiers": [], "additional_components": [ "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54FD6", "DDB_G0290929", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54FD6", "DDB_G0290929", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307" ] }, "reaction_10582550": { "compartment": "compartment_7660", "id": "reaction_10582550", "reactome": "R-DDI-109638", "name": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581550", "species_10578889" ], "products": [ "species_10581552" ], "modifiers": [], "additional_components": [ "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54FD6", "DDB_G0290929", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54FD6", "DDB_G0290929" ] }, "reaction_10582552": { "compartment": "compartment_7660", "id": "reaction_10582552", "reactome": "R-DDI-109639", "name": "Formation of the closed pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580699", "species_10581554" ], "products": [ "species_10581638" ], "modifiers": [], "additional_components": [ "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54FD6", "DDB_G0290929", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54FD6", "DDB_G0290929", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307" ] }, "reaction_10582721": { "compartment": "compartment_7660", "id": "reaction_10582721", "reactome": "R-DDI-110227", "name": "Cleavage of dihydrouracil by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582718" ], "products": [ "species_30140", "species_10582704" ], "modifiers": [ [ "species_10582718", "catalyst" ] ], "additional_components": [ "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247" ] }, "reaction_10582691": { "compartment": "compartment_7660", "id": "reaction_10582691", "reactome": "R-DDI-110215", "name": "Cleavage of uracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582684" ], "products": [ "species_29554", "species_10582688" ], "modifiers": [ [ "species_10582684", "catalyst" ] ], "additional_components": [ "P53766", "DDB_G0277877", "P53766", "DDB_G0277877", "P53766", "DDB_G0277877" ] }, "reaction_10582707": { "compartment": "compartment_7660", "id": "reaction_10582707", "reactome": "R-DDI-110224", "name": "Cleavage of thymine glycol by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582702" ], "products": [ "species_110223", "species_10582704" ], "modifiers": [ [ "species_10582702", "catalyst" ] ], "additional_components": [ "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247" ] }, "reaction_10582728": { "compartment": "compartment_7660", "id": "reaction_10582728", "reactome": "R-DDI-110229", "name": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582725" ], "products": [ "species_5637659", "species_10582704" ], "modifiers": [ [ "species_10582725", "catalyst" ] ], "additional_components": [ "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247" ] }, "reaction_10582747": { "compartment": "compartment_7660", "id": "reaction_10582747", "reactome": "R-DDI-110244", "name": "Excision of FapyG by OGG1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582744" ], "products": [ "species_5636006", "species_10582739" ], "modifiers": [ [ "species_10582744", "catalyst" ] ], "additional_components": [ "Q54CZ3", "DDB_G0292618", "Q54CZ3", "DDB_G0292618", "Q54CZ3", "DDB_G0292618" ] }, "reaction_10582698": { "compartment": "compartment_7660", "id": "reaction_10582698", "reactome": "R-DDI-110217", "name": "Cleavage of 5-hydroxyluracil by UNG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582695" ], "products": [ "species_110216", "species_10582688" ], "modifiers": [ [ "species_10582695", "catalyst" ] ], "additional_components": [ "P53766", "DDB_G0277877", "P53766", "DDB_G0277877", "P53766", "DDB_G0277877" ] }, "reaction_10582714": { "compartment": "compartment_7660", "id": "reaction_10582714", "reactome": "R-DDI-110226", "name": "Cleavage of cytosine glycol by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582711" ], "products": [ "species_10582704", "species_110225" ], "modifiers": [ [ "species_10582711", "catalyst" ] ], "additional_components": [ "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247", "Q86K43", "DDB_G0277247" ] }, "reaction_10604323": { "compartment": "compartment_17963", "id": "reaction_10604323", "reactome": "R-DDI-4837364", "name": "Secretion of SOD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604321" ], "products": [ "species_10602381" ], "modifiers": [], "additional_components": [ "species_29426", "species_437295", "Q55GQ5", "DDB_G0267420", "species_29426", "Q55GQ5", "DDB_G0267420", "species_437295" ] }, "reaction_10602402": { "compartment": "compartment_70101", "id": "reaction_10602402", "reactome": "R-DDI-3299691", "name": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_1222424" ], "products": [ "species_29368", "species_29408" ], "modifiers": [ [ "species_10602399", "catalyst" ] ], "additional_components": [ "species_29426", "species_437295", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993", "Q55GQ5", "DDB_G0267420" ] }, "reaction_10602373": { "compartment": "compartment_5460", "id": "reaction_10602373", "reactome": "R-DDI-3299680", "name": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_3299683" ], "products": [ "species_113533", "species_1614617" ], "modifiers": [ [ "species_10602370", "catalyst" ] ], "additional_components": [ "species_266099", "Q55BJ9", "DDB_G0271106" ] }, "reaction_10602664": { "compartment": "compartment_5460", "id": "reaction_10602664", "reactome": "R-DDI-3323079", "name": "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_1655882", "species_113600" ], "products": [ "species_113563", "species_1655887" ], "modifiers": [ [ "species_10602661", "catalyst" ] ], "additional_components": [ "Q8T137", "DDB_G0272754", "species_113596" ] }, "reaction_10602668": { "compartment": "compartment_70616", "id": "reaction_10602668", "reactome": "R-DDI-3341294", "name": "Superoxide reduces cytochrome c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3341308", "species_10584033" ], "products": [ "species_10584031", "species_189461" ], "modifiers": [], "additional_components": [ "CHEBI:38574", "Q869N1", "DDB_G0275537", "CHEBI:38573", "Q869N1", "DDB_G0275537" ] }, "reaction_10602384": { "compartment": "compartment_984", "id": "reaction_10602384", "reactome": "R-DDI-3299682", "name": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_3299686" ], "products": [ "species_351629", "species_352327" ], "modifiers": [ [ "species_10602381", "catalyst" ] ], "additional_components": [ "species_29426", "Q55GQ5", "DDB_G0267420", "species_437295" ] }, "reaction_10602421": { "compartment": "compartment_70101", "id": "reaction_10602421", "reactome": "R-DDI-3299753", "name": "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602414" ], "products": [ "species_10602399", "species_10602418" ], "modifiers": [ [ "species_10602414", "catalyst" ] ], "additional_components": [ "CHEBI:49552", "species_29426", "Q54F73", "DDB_G0291031", "Q55GQ5", "DDB_G0267420", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993", "species_29426", "species_437295", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993", "Q55GQ5", "DDB_G0267420", "species_29426", "CHEBI:49552", "Q54F73", "DDB_G0291031", "CHEBI:49552", "species_29426", "Q54F73", "DDB_G0291031", "Q55GQ5", "DDB_G0267420", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993" ] }, "reaction_10603063": { "compartment": "compartment_70101", "id": "reaction_10603063", "reactome": "R-DDI-3697860", "name": "SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602412", "species_10603059" ], "products": [ "species_10603061" ], "modifiers": [], "additional_components": [ "species_29426", "Q55GQ5", "DDB_G0267420", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993", "CHEBI:49552", "species_29426", "Q54F73", "DDB_G0291031", "CHEBI:49552", "species_29426", "Q54F73", "DDB_G0291031", "Q55GQ5", "DDB_G0267420", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993" ] }, "reaction_10616759": { "compartment": "compartment_12045", "id": "reaction_10616759", "reactome": "R-DDI-6807557", "name": "NOX4, NOX5 reduce O2 to O2.-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29364" ], "products": [ "species_70106", "species_1222424", "species_29366" ], "modifiers": [ [ "species_10616756", "catalyst" ] ], "additional_components": [ "Q867X6", "DDB_G0267460", "Q54F44", "DDB_G0291117", "Q86GL4", "DDB_G0287101", "Q9XYS3", "DDB_G0289653" ] }, "reaction_10623544": { "compartment": "compartment_70101", "id": "reaction_10623544", "reactome": "R-DDI-8951723", "name": "2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603061" ], "products": [ "species_10602414" ], "modifiers": [], "additional_components": [ "CHEBI:49552", "species_29426", "Q54F73", "DDB_G0291031", "Q55GQ5", "DDB_G0267420", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993", "CHEBI:49552", "species_29426", "Q54F73", "DDB_G0291031", "Q55GQ5", "DDB_G0267420", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993" ] }, "reaction_10603066": { "compartment": "compartment_5460", "id": "reaction_10603066", "reactome": "R-DDI-3697894", "name": "PRDX5 reduces peroxynitrite to nitrite using TXN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602633", "species_3697881" ], "products": [ "species_10602636", "species_3697842", "species_113521" ], "modifiers": [ [ "species_10602650", "catalyst" ] ], "additional_components": [ "DDB_G0284939", "DDB_G0284939", "DDB_G0285741" ] }, "reaction_10603197": { "compartment": "compartment_17927", "id": "reaction_10603197", "reactome": "R-DDI-3777112", "name": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3341308", "species_163953" ], "products": [ "species_189481", "species_189461" ], "modifiers": [ [ "species_10603194", "catalyst" ] ], "additional_components": [ "species_437295", "species_29426", "Q54RN1", "DDB_G0283021", "Q54RQ1", "DDB_G0282993", "Q55GQ5", "DDB_G0267420" ] }, "reaction_10581788": { "compartment": "compartment_17951", "id": "reaction_10581788", "reactome": "R-DDI-76031", "name": "2 H2O2 => O2 + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113575" ], "products": [ "species_113535", "species_141343" ], "modifiers": [ [ "species_10581785", "catalyst" ] ], "additional_components": [ "species_917877", "species_29364", "O77229", "DDB_G0274595" ] }, "reaction_10602655": { "compartment": "compartment_5460", "id": "reaction_10602655", "reactome": "R-DDI-3322995", "name": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602633", "species_1614617" ], "products": [ "species_10602636", "species_113521" ], "modifiers": [ [ "species_10602652", "catalyst" ] ], "additional_components": [ "DDB_G0284939", "DDB_G0284939", "Q54W09", "DDB_G0279973", "Q54N76", "DDB_G0285741" ] }, "reaction_10602686": { "compartment": "compartment_70101", "id": "reaction_10602686", "reactome": "R-DDI-3343700", "name": "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_29408" ], "products": [ "species_29356", "species_111745" ], "modifiers": [ [ "species_10602683", "catalyst" ] ], "additional_components": [ "Q556P3", "DDB_G0273153", "Q55FF3", "DDB_G0268138", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q54VI4", "DDB_G0280317", "Q556G3", "DDB_G0272632", "Q54SE2", "DDB_G0282517" ] }, "reaction_10600900": { "compartment": "compartment_70101", "id": "reaction_10600900", "reactome": "R-DDI-2393939", "name": "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1131972" ], "products": [ "species_73578", "species_76577" ], "modifiers": [ [ "species_10600897", "catalyst" ] ], "additional_components": [ "species_29926", "Q54S89", "DDB_G0282603" ] }, "reaction_10577424": { "compartment": "compartment_7660", "id": "reaction_10577424", "reactome": "R-DDI-69053", "name": "RFC binding displaces Pol Alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577420", "species_10577245" ], "products": [ "species_10577422" ], "modifiers": [], "additional_components": [ "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MD4", "DDB_G0286027", "Q54MH9", "DDB_G0285961", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MD4", "DDB_G0286027", "Q54MH9", "DDB_G0285961" ] }, "reaction_10577462": { "compartment": "compartment_7660", "id": "reaction_10577462", "reactome": "R-DDI-69074", "name": "Formation of Processive Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577437", "species_10577458" ], "products": [ "species_10577460" ], "modifiers": [], "additional_components": [ "Q54K47", "DDB_G0287607", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54K47", "DDB_G0287607", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731" ] }, "reaction_10577435": { "compartment": "compartment_7660", "id": "reaction_10577435", "reactome": "R-DDI-69063", "name": "Loading of PCNA - Sliding Clamp Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577422", "species_29358", "species_10577431" ], "products": [ "species_113582", "species_10577433" ], "modifiers": [], "additional_components": [ "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MD4", "DDB_G0286027", "Q54MH9", "DDB_G0285961", "Q54K47", "DDB_G0287607", "Q54K47", "DDB_G0287607", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MD4", "DDB_G0286027", "Q54MH9", "DDB_G0285961" ] }, "reaction_10577439": { "compartment": "compartment_7660", "id": "reaction_10577439", "reactome": "R-DDI-69068", "name": "RFC dissociates after sliding clamp formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577433" ], "products": [ "species_10577420", "species_10577437" ], "modifiers": [], "additional_components": [ "Q54K47", "DDB_G0287607", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MD4", "DDB_G0286027", "Q54MH9", "DDB_G0285961", "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MD4", "DDB_G0286027", "Q54MH9", "DDB_G0285961", "Q54K47", "DDB_G0287607", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731" ] }, "reaction_10618449": { "compartment": "compartment_20699", "id": "reaction_10618449", "reactome": "R-DDI-8847887", "name": "RAB33B:GTP binds RIC1:RGP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618445", "species_10618439" ], "products": [ "species_10618447" ], "modifiers": [], "additional_components": [ "Q54WR7", "DDB_G0279477", "Q76NU4", "DDB_G0277397", "O76173", "DDB_G0269174", "species_29438", "O76173", "DDB_G0269174", "species_29438", "Q54WR7", "DDB_G0279477", "Q76NU4", "DDB_G0277397" ] }, "reaction_10618433": { "compartment": "compartment_20699", "id": "reaction_10618433", "reactome": "R-DDI-8847883", "name": "CYTH proteins stimulate ARF1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618424" ], "products": [ "species_10618430" ], "modifiers": [ [ "species_10618424", "catalyst" ] ], "additional_components": [ "species_29438", "O00909", "DDB_G0289173", "Q54Y34", "DDB_G0292332", "Q1ZXA5", "DDB_G0292332", "Q54YV7", "DDB_G0278057", "Q54HK2", "DDB_G0289435", "Q55AR1", "DDB_G0271792", "Q54JJ3", "DDB_G0288015", "Q54SH9", "DDB_G0282457", "Q54V41", "DDB_G0280633", "Q54V47", "DDB_G0280621", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "O00909", "DDB_G0289173", "Q54Y34", "DDB_G0292332", "Q1ZXA5", "DDB_G0292332", "Q54YV7", "DDB_G0278057", "Q54HK2", "DDB_G0289435", "Q55AR1", "DDB_G0271792", "Q54JJ3", "DDB_G0288015", "Q54SH9", "DDB_G0282457", "Q54V41", "DDB_G0280633", "Q54V47", "DDB_G0280621", "Q54VB0", "DDB_G0280479", "species_29420", "species_29438", "O00909", "DDB_G0289173", "Q54Y34", "DDB_G0292332", "Q1ZXA5", "DDB_G0292332", "Q54YV7", "DDB_G0278057", "Q54HK2", "DDB_G0289435", "Q55AR1", "DDB_G0271792", "Q54JJ3", "DDB_G0288015", "Q54SH9", "DDB_G0282457", "Q54V41", "DDB_G0280633", "Q54V47", "DDB_G0280621", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771" ] }, "reaction_10618612": { "compartment": "compartment_20699", "id": "reaction_10618612", "reactome": "R-DDI-8849748", "name": "The COG complex binds RABs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617130", "species_10618608" ], "products": [ "species_10618610" ], "modifiers": [], "additional_components": [ "Q54LC8", "DDB_G0286705", "Q54C87", "DDB_G0293106", "Q54ZB3", "DDB_G0277691", "Q54UC2", "DDB_G0281163", "Q55BB8", "DDB_G0271388", "Q54HE0", "DDB_G0289535", "Q54CT0", "DDB_G0292784", "Q54TT4", "DDB_G0281511", "Q54G48", "DDB_G0290407", "Q54FL2", "DDB_G0290783", "Q54S62", "DDB_G0294577", "Q54P07", "DDB_G0285051", "Q55EF0", "DDB_G0269262", "Q54S63", "DDB_G0282651", "Q86JC8", "DDB_G0275955", "Q55EG6", "DDB_G0268910", "Q8T193", "DDB_G0294577", "Q86JP5", "DDB_G0271980", "Q1ZXG2", "DDB_G0294577", "Q54E92", "DDB_G0291738", "Q1ZXN9", "DDB_G0294577", "species_29438", "Q559X6", "DDB_G0272138", "Q55ET3", "DDB_G0268760", "P36409", "DDB_G0292268", "Q55FK2", "DDB_G0268068", "Q54G48", "DDB_G0290407", "Q54FL2", "DDB_G0290783", "Q54S62", "DDB_G0294577", "Q54P07", "DDB_G0285051", "Q55EF0", "DDB_G0269262", "Q54S63", "DDB_G0282651", "Q86JC8", "DDB_G0275955", "Q55EG6", "DDB_G0268910", "Q8T193", "DDB_G0294577", "Q86JP5", "DDB_G0271980", "Q1ZXG2", "DDB_G0294577", "Q54E92", "DDB_G0291738", "Q1ZXN9", "DDB_G0294577", "species_29438", "Q559X6", "DDB_G0272138", "Q55ET3", "DDB_G0268760", "P36409", "DDB_G0292268", "Q55FK2", "DDB_G0268068", "Q54LC8", "DDB_G0286705", "Q54C87", "DDB_G0293106", "Q54ZB3", "DDB_G0277691", "Q54UC2", "DDB_G0281163", "Q55BB8", "DDB_G0271388", "Q54HE0", "DDB_G0289535", "Q54CT0", "DDB_G0292784", "Q54TT4", "DDB_G0281511" ] }, "reaction_10618426": { "compartment": "compartment_20699", "id": "reaction_10618426", "reactome": "R-DDI-8847880", "name": "CYTH proteins bind ARF1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598835", "species_10618402" ], "products": [ "species_10618424" ], "modifiers": [], "additional_components": [ "species_29438", "O00909", "DDB_G0289173", "Q54Y34", "DDB_G0292332", "Q1ZXA5", "DDB_G0292332", "Q54YV7", "DDB_G0278057", "Q54HK2", "DDB_G0289435", "Q55AR1", "DDB_G0271792", "Q54JJ3", "DDB_G0288015", "Q54SH9", "DDB_G0282457", "Q54V41", "DDB_G0280633", "Q54V47", "DDB_G0280621", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771", "species_29438", "O00909", "DDB_G0289173", "Q54Y34", "DDB_G0292332", "Q1ZXA5", "DDB_G0292332", "Q54YV7", "DDB_G0278057", "Q54HK2", "DDB_G0289435", "Q55AR1", "DDB_G0271792", "Q54JJ3", "DDB_G0288015", "Q54SH9", "DDB_G0282457", "Q54V41", "DDB_G0280633", "Q54V47", "DDB_G0280621", "Q54VB0", "DDB_G0280479", "Q86KG9", "DDB_G0290771", "Q54X30", "DDB_G0290771", "Q54FL9", "DDB_G0290771" ] }, "reaction_10618379": { "compartment": "compartment_20699", "id": "reaction_10618379", "reactome": "R-DDI-8847637", "name": "NSF and SNAPs bind the cis-SNARE at the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611694", "species_10611703", "species_10618375" ], "products": [ "species_10618377" ], "modifiers": [], "additional_components": [ "Q75JI3", "DDB_G0276153", "Q54NP6", "DDB_G0285111", "Q54BK5", "DDB_G0293712", "Q54ZH1", "DDB_G0277565", "Q54SJ2", "DDB_G0282433", "Q54QH2", "DDB_G0283831", "Q54BK5", "DDB_G0293712", "Q54ZH1", "DDB_G0277565", "Q54SJ2", "DDB_G0282433", "Q54QH2", "DDB_G0283831", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153" ] }, "reaction_10617758": { "compartment": "compartment_20699", "id": "reaction_10617758", "reactome": "R-DDI-6811433", "name": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617754", "species_10617130" ], "products": [ "species_10617756" ], "modifiers": [], "additional_components": [ "Q553C3", "DDB_G0275765", "Q54CK6", "DDB_G0292974", "Q54R67", "DDB_G0283363", "Q54QH2", "DDB_G0283831", "Q551H5", "DDB_G0276575", "Q54PW2", "DDB_G0284185", "Q54I20", "DDB_G0289063", "Q54PQ5", "DDB_G0289063", "Q54ZH1", "DDB_G0277565", "Q54SJ2", "DDB_G0282433", "Q54GE3", "DDB_G0290213", "Q55FD0", "DDB_G0268452", "Q55GN5", "DDB_G0267590", "Q54LC8", "DDB_G0286705", "Q54C87", "DDB_G0293106", "Q54ZB3", "DDB_G0277691", "Q54UC2", "DDB_G0281163", "Q55BB8", "DDB_G0271388", "Q54HE0", "DDB_G0289535", "Q54CT0", "DDB_G0292784", "Q54TT4", "DDB_G0281511", "Q54LC8", "DDB_G0286705", "Q54C87", "DDB_G0293106", "Q54ZB3", "DDB_G0277691", "Q54UC2", "DDB_G0281163", "Q55BB8", "DDB_G0271388", "Q54HE0", "DDB_G0289535", "Q54CT0", "DDB_G0292784", "Q54TT4", "DDB_G0281511", "Q553C3", "DDB_G0275765", "Q54CK6", "DDB_G0292974", "Q54R67", "DDB_G0283363", "Q54QH2", "DDB_G0283831", "Q551H5", "DDB_G0276575", "Q54PW2", "DDB_G0284185", "Q54I20", "DDB_G0289063", "Q54PQ5", "DDB_G0289063", "Q54ZH1", "DDB_G0277565", "Q54SJ2", "DDB_G0282433", "Q54GE3", "DDB_G0290213", "Q55FD0", "DDB_G0268452", "Q55GN5", "DDB_G0267590" ] }, "reaction_10618382": { "compartment": "compartment_20699", "id": "reaction_10618382", "reactome": "R-DDI-8847638", "name": "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618377", "species_113592" ], "products": [ "species_10611694", "species_10617256", "species_29370", "species_10617258", "species_10611703", "species_10617143", "species_10617254" ], "modifiers": [ [ "species_10618377", "catalyst" ] ], "additional_components": [ "Q54BK5", "DDB_G0293712", "Q54ZH1", "DDB_G0277565", "Q54SJ2", "DDB_G0282433", "Q54QH2", "DDB_G0283831", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153", "Q75JI3", "DDB_G0276153", "DDB_G0282433", "DDB_G0277565", "Q54NP6", "DDB_G0285111", "DDB_G0293712", "DDB_G0283831", "Q54BK5", "DDB_G0293712", "Q54ZH1", "DDB_G0277565", "Q54SJ2", "DDB_G0282433", "Q54QH2", "DDB_G0283831", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153" ] }, "reaction_10606649": { "compartment": "compartment_70101", "id": "reaction_10606649", "reactome": "R-DDI-5665854", "name": "ADRM1:26S proteaseome binds UCHL5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606638", "species_10606645" ], "products": [ "species_10606647" ], "modifiers": [], "additional_components": [ "DDB_G0285527", "Q556N5", "DDB_G0272624", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408", "Q556N5", "DDB_G0272624", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408", "Q54N38", "DDB_G0285527" ] }, "reaction_10611049": { "compartment": "compartment_70101", "id": "reaction_10611049", "reactome": "R-DDI-5690319", "name": "UCHL1, UCHL3 cleave ubiquitin adducts", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10611044" ], "products": [ "species_1131871", "species_10611046" ], "modifiers": [ [ "species_10611044", "catalyst" ] ], "additional_components": [ "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14797", "DDB_G0276765", "Q54T48", "DDB_G0282007", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54T48", "DDB_G0282007", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P14797", "DDB_G0276765", "Q54T48", "DDB_G0282007" ] }, "reaction_10606686": { "compartment": "compartment_70101", "id": "reaction_10606686", "reactome": "R-DDI-5665871", "name": "ADRM1 binds 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577240", "species_10606643" ], "products": [ "species_10606645" ], "modifiers": [], "additional_components": [ "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408", "DDB_G0272624", "Q556N5", "DDB_G0272624", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10590556": { "compartment": "compartment_70101", "id": "reaction_10590556", "reactome": "R-DDI-391266", "name": "Association of CCT/TriC with sphingosine kinase 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590508", "species_10590552" ], "products": [ "species_10590554" ], "modifiers": [], "additional_components": [ "DDB_G0284545", "Q55BM4", "DDB_G0269190", "Q54TD3", "DDB_G0281849", "Q54ER7", "DDB_G0291225", "Q76NU3", "DDB_G0277493", "Q54ES9", "DDB_G0291358", "Q54CL2", "DDB_G0292872", "species_29370", "Q54TH8", "DDB_G0281741", "Q552J0", "DDB_G0276233", "Q55BM4", "DDB_G0269190", "Q54TD3", "DDB_G0281849", "Q54ER7", "DDB_G0291225", "Q76NU3", "DDB_G0277493", "Q54ES9", "DDB_G0291358", "Q54CL2", "DDB_G0292872", "species_29370", "Q54TH8", "DDB_G0281741", "Q552J0", "DDB_G0276233", "Q6B516", "DDB_G0284545" ] }, "reaction_10617873": { "compartment": "compartment_70101", "id": "reaction_10617873", "reactome": "R-DDI-6814119", "name": "TRiC/CCT binds unfolded G-protein beta subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590552", "species_10589812" ], "products": [ "species_10617871" ], "modifiers": [], "additional_components": [ "Q55BM4", "DDB_G0269190", "Q54TD3", "DDB_G0281849", "Q54ER7", "DDB_G0291225", "Q76NU3", "DDB_G0277493", "Q54ES9", "DDB_G0291358", "Q54CL2", "DDB_G0292872", "species_29370", "Q54TH8", "DDB_G0281741", "Q552J0", "DDB_G0276233", "DDB_G0277143", "P36408", "DDB_G0277143", "Q55BM4", "DDB_G0269190", "Q54TD3", "DDB_G0281849", "Q54ER7", "DDB_G0291225", "Q76NU3", "DDB_G0277493", "Q54ES9", "DDB_G0291358", "Q54CL2", "DDB_G0292872", "species_29370", "Q54TH8", "DDB_G0281741", "Q552J0", "DDB_G0276233" ] }, "reaction_10617879": { "compartment": "compartment_70101", "id": "reaction_10617879", "reactome": "R-DDI-6814120", "name": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617877" ], "products": [ "species_10617871", "species_29372" ], "modifiers": [], "additional_components": [ "Q55BM4", "DDB_G0269190", "Q54TD3", "DDB_G0281849", "Q54ER7", "DDB_G0291225", "Q76NU3", "DDB_G0277493", "Q54ES9", "DDB_G0291358", "species_113592", "Q54CL2", "DDB_G0292872", "Q54TH8", "DDB_G0281741", "Q552J0", "DDB_G0276233", "P36408", "DDB_G0277143", "P36408", "DDB_G0277143", "Q55BM4", "DDB_G0269190", "Q54TD3", "DDB_G0281849", "Q54ER7", "DDB_G0291225", "Q76NU3", "DDB_G0277493", "Q54ES9", "DDB_G0291358", "Q54CL2", "DDB_G0292872", "species_29370", "Q54TH8", "DDB_G0281741", "Q552J0", "DDB_G0276233" ] }, "reaction_10617881": { "compartment": "compartment_70101", "id": "reaction_10617881", "reactome": "R-DDI-6814124", "name": "ATP binds G-protein beta associated TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617871", "species_113592" ], "products": [ "species_29370", "species_10617877" ], "modifiers": [], "additional_components": [ "P36408", "DDB_G0277143", "Q55BM4", "DDB_G0269190", "Q54TD3", "DDB_G0281849", "Q54ER7", "DDB_G0291225", "Q76NU3", "DDB_G0277493", "Q54ES9", "DDB_G0291358", "Q54CL2", "DDB_G0292872", "species_29370", "Q54TH8", "DDB_G0281741", "Q552J0", "DDB_G0276233", "Q55BM4", "DDB_G0269190", "Q54TD3", "DDB_G0281849", "Q54ER7", "DDB_G0291225", "Q76NU3", "DDB_G0277493", "Q54ES9", "DDB_G0291358", "species_113592", "Q54CL2", "DDB_G0292872", "Q54TH8", "DDB_G0281741", "Q552J0", "DDB_G0276233", "P36408", "DDB_G0277143" ] }, "reaction_10611316": { "compartment": "compartment_984", "id": "reaction_10611316", "reactome": "R-DDI-5693346", "name": "CECRI deaminates Ade-Rib to Ino", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_83908" ], "products": [ "species_2022135", "species_83921" ], "modifiers": [ [ "species_10611313", "catalyst" ] ], "additional_components": [ "species_29426", "Q553U5", "DDB_G0275179" ] }, "reaction_10608345": { "compartment": "compartment_3828046", "id": "reaction_10608345", "reactome": "R-DDI-5684864", "name": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5685882", "species_10608214" ], "products": [ "species_10608286", "species_10608238", "species_10608262" ], "modifiers": [ [ "species_10608342", "catalyst" ] ], "additional_components": [ "B0G0Z4", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q55EI1", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q54SX7", "DDB_G0292508", "Q54WE0", "DDB_G0279713", "Q54WE4", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q54SX7", "DDB_G0292508", "Q54WE0", "DDB_G0279713", "Q54WE4", "DDB_G0292508", "B0G0Z4", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q55EI1", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q54SX7", "DDB_G0292508", "Q54WE0", "DDB_G0279713", "Q54WE4", "DDB_G0292508", "B0G0Z4", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q55EI1", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "B0G0Z4", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q55EI1", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q54SX7", "DDB_G0292508", "Q54WE0", "DDB_G0279713", "Q54WE4", "DDB_G0292508", "P04989", "DDB_G0279799", "Q23894", "DDB_G0283867", "Q54RQ2", "DDB_G0282991", "Q54TR1", "DDB_G0281605", "Q54UH2", "DDB_G0282991", "Q54UH3", "DDB_G0282991", "Q86KD4", "DDB_G0282991", "O76856", "DDB_G0279411" ] }, "reaction_10612937": { "compartment": "compartment_3828046", "id": "reaction_10612937", "reactome": "R-DDI-6791016", "name": "SFTPB binds itself", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608238" ], "products": [ "species_10608347" ], "modifiers": [], "additional_components": [ "Q54LG3", "DDB_G0292508", "Q54SX7", "DDB_G0292508", "Q54WE0", "DDB_G0279713", "Q54WE4", "DDB_G0292508", "B0G0Z4", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q55EI1", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q54SX7", "DDB_G0292508", "Q54WE0", "DDB_G0279713", "Q54WE4", "DDB_G0292508", "B0G0Z4", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q55EI1", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508" ] }, "reaction_10626233": { "compartment": "compartment_12045", "id": "reaction_10626233", "reactome": "R-DDI-9624789", "name": "pro-SFTPB translocates from ER membrane to multivesicle body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626231" ], "products": [ "species_10608214" ], "modifiers": [], "additional_components": [ "Q54C60", "DDB_G0293010", "Q55EI1", "DDB_G0292508", "B0G0Z4", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54SX7", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q54WE4", "DDB_G0292508", "Q54WE0", "DDB_G0279713", "B0G0Z4", "DDB_G0292508", "Q55C30", "DDB_G0292508", "Q54C60", "DDB_G0293010", "Q55EI1", "DDB_G0292508", "Q54D30", "DDB_G0292508", "Q86KA8", "DDB_G0292508", "Q54F52", "DDB_G0292508", "Q54LG3", "DDB_G0292508", "Q54SX7", "DDB_G0292508", "Q54WE0", "DDB_G0279713", "Q54WE4", "DDB_G0292508" ] }, "reaction_10608074": { "compartment": "compartment_2133233", "id": "reaction_10608074", "reactome": "R-DDI-5683714", "name": "ABCA3 transports PC, PG from ER membrane to lamellar body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5684863" ], "products": [ "species_29372", "species_29370", "species_5684869" ], "modifiers": [ [ "species_10608071", "catalyst" ] ], "additional_components": [ "species_426925", "species_1483256", "species_426925", "species_1483256", "Q8T6J1", "DDB_G0291245", "Q8T6J2", "DDB_G0274119", "Q8T6J5", "DDB_G0267438", "Q54BT5", "DDB_G0293436", "Q555Z5", "DDB_G0274121", "Q55BC0", "DDB_G0271138", "Q8T5Z7", "DDB_G0291994" ] }, "reaction_10592403": { "compartment": "compartment_1462052", "id": "reaction_10592403", "reactome": "R-DDI-437085", "name": "ZnT5 transports zinc into secretory granules in pancreatic beta cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216785" ], "modifiers": [ [ "species_10592400", "catalyst" ] ], "additional_components": [ "Q54F34", "DDB_G0291141", "Q55E98", "DDB_G0291141" ] }, "reaction_10592411": { "compartment": "compartment_20699", "id": "reaction_10592411", "reactome": "R-DDI-437136", "name": "SLC30A8 transports Zn2+ from cytosol to secretory granule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216785" ], "modifiers": [ [ "species_10592408", "catalyst" ] ], "additional_components": [ "DDB_G0283629" ] }, "reaction_10589007": { "compartment": "compartment_876", "id": "reaction_10589007", "reactome": "R-DDI-265177", "name": "Exocyst complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10588988", "species_10588973", "species_10589003", "species_10588968", "species_10588998", "species_10588983", "species_10588978", "species_10588993" ], "products": [ "species_10589005" ], "modifiers": [], "additional_components": [ "DDB_G0279991", "DDB_G0280081", "DDB_G0272991", "DDB_G0284833", "DDB_G0293520", "DDB_G0293936", "DDB_G0287881", "DDB_G0285067", "Q54NV1", "DDB_G0285067", "B0G163", "DDB_G0287881", "Q54B27", "DDB_G0293936", "Q54BP6", "DDB_G0293520", "Q54P76", "DDB_G0284833", "Q558Z9", "DDB_G0272991", "Q54VX5", "DDB_G0280081", "Q54VZ8", "DDB_G0279991" ] }, "reaction_10599268": { "compartment": "compartment_70101", "id": "reaction_10599268", "reactome": "R-DDI-1799332", "name": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599262", "species_10599264" ], "products": [ "species_10599266" ], "modifiers": [], "additional_components": [ "Q556L1", "DDB_G0272590", "Q54EP7", "DDB_G0291412", "Q55GL2", "DDB_G0267622", "Q554G7", "DDB_G0275211", "Q75K18", "DDB_G0275455", "Q1ZXE8", "DDB_G0285821", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q556L1", "DDB_G0272590", "Q54EP7", "DDB_G0291412", "Q55GL2", "DDB_G0267622", "Q554G7", "DDB_G0275211", "Q75K18", "DDB_G0275455", "Q1ZXE8", "DDB_G0285821" ] }, "reaction_10583761": { "compartment": "compartment_70101", "id": "reaction_10583761", "reactome": "R-DDI-156913", "name": "Regeneration of eEF1A:GTP by eEF1B activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10583756", "species_10583752" ], "products": [ "species_10583758", "species_10583738" ], "modifiers": [ [ "species_10583752", "catalyst" ] ], "additional_components": [ "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "species_29420", "Q9GRF8", "DDB_G0284035", "B0G141", "DDB_G0282979", "Q9GRF8", "DDB_G0284035", "B0G141", "DDB_G0282979", "species_29420", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "species_29438", "Q9GRF8", "DDB_G0284035", "B0G141", "DDB_G0282979" ] }, "reaction_10583771": { "compartment": "compartment_70101", "id": "reaction_10583771", "reactome": "R-DDI-156930", "name": "GTP-binding activates eEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10583767" ], "products": [ "species_10583769" ], "modifiers": [], "additional_components": [ "DDB_G0288373", "P15112", "DDB_G0288373", "species_29438" ] }, "reaction_10583754": { "compartment": "compartment_70101", "id": "reaction_10583754", "reactome": "R-DDI-156910", "name": "Formation of eEF1B complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583743", "species_10583750", "species_10583745" ], "products": [ "species_10583752" ], "modifiers": [], "additional_components": [ "DDB_G0284035", "DDB_G0282979", "DDB_G0284035", "Q9GRF8", "DDB_G0284035", "B0G141", "DDB_G0282979" ] }, "reaction_10583720": { "compartment": "compartment_70101", "id": "reaction_10583720", "reactome": "R-DDI-156823", "name": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583711", "species_10583716" ], "products": [ "species_10583718" ], "modifiers": [], "additional_components": [ "Q75K16", "DDB_G0275459", "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "Q54BM2", "DDB_G0293558", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "DDB_G0275881", "Q553M7", "DDB_G0275881", "Q75K16", "DDB_G0275459", "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "Q54BM2", "DDB_G0293558", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395" ] }, "reaction_10583724": { "compartment": "compartment_70101", "id": "reaction_10583724", "reactome": "R-DDI-156826", "name": "Dissociation of L13a from the 60s ribosomal subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580367" ], "products": [ "species_10583722", "species_10580149" ], "modifiers": [], "additional_components": [ "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "DDB_G0275881" ] }, "reaction_10580065": { "compartment": "compartment_70101", "id": "reaction_10580065", "reactome": "R-DDI-72631", "name": "Formation of the cap-binding eIF4F complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580029", "species_10580024", "species_10580019" ], "products": [ "species_10580031" ], "modifiers": [], "additional_components": [ "DDB_G0275395", "DDB_G0268574", "P90529", "DDB_G0269146", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395" ] }, "reaction_10583713": { "compartment": "compartment_70101", "id": "reaction_10583713", "reactome": "R-DDI-156808", "name": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583709", "species_10583704", "species_10580008", "species_10579985" ], "products": [ "species_10583711", "species_10579985" ], "modifiers": [], "additional_components": [ "DDB_G0293558", "Q75K16", "DDB_G0275459", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "DDB_G0278205", "Q75K16", "DDB_G0275459", "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "Q54BM2", "DDB_G0293558", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "DDB_G0278205" ] }, "reaction_10583773": { "compartment": "compartment_70101", "id": "reaction_10583773", "reactome": "R-DDI-157849", "name": "Formation of translation initiation complexes containing mRNA that does not circularize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580008", "species_10580071", "species_10579985" ], "products": [ "species_10580040", "species_10579985" ], "modifiers": [], "additional_components": [ "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "Q75K16", "DDB_G0275459", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "DDB_G0278205", "Q75K16", "DDB_G0275459", "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "DDB_G0278205" ] }, "reaction_10580074": { "compartment": "compartment_70101", "id": "reaction_10580074", "reactome": "R-DDI-72647", "name": "Cap-bound mRNA is activated by helicases ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10580038", "species_10580036", "species_10580069", "species_10580019" ], "products": [ "species_29372", "species_29370", "species_10580071", "species_10580019", "species_72595" ], "modifiers": [ [ "species_10580019", "catalyst" ] ], "additional_components": [ "DDB_G0275459", "DDB_G0275459", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "P90529", "DDB_G0269146", "Q75K16", "DDB_G0275459", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "P90529", "DDB_G0269146", "P90529", "DDB_G0269146" ] }, "reaction_10580063": { "compartment": "compartment_70101", "id": "reaction_10580063", "reactome": "R-DDI-72622", "name": "Release of eIF4E from the inactive eIF4E:4E-BP complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580061" ], "products": [ "species_10580059", "species_10580024" ], "modifiers": [], "additional_components": [ "Q55FE0", "DDB_G0268574", "Q54DU8", "DDB_G0291990", "DDB_G0291990", "DDB_G0268574" ] }, "reaction_10580054": { "compartment": "compartment_70101", "id": "reaction_10580054", "reactome": "R-DDI-72621", "name": "Ribosomal scanning ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10580040" ], "products": [ "species_29372", "species_29370", "species_10580040" ], "modifiers": [ [ "species_72617", "catalyst" ], [ "species_113592", "catalyst" ] ], "additional_components": [ "Q75K16", "DDB_G0275459", "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "Q75K16", "DDB_G0275459", "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395" ] }, "reaction_10580396": { "compartment": "compartment_70101", "id": "reaction_10580396", "reactome": "R-DDI-72697", "name": "Start codon recognition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580045", "species_10580040", "species_72617", "species_10580002", "species_10579985" ], "products": [ "species_10580045", "species_10580040", "species_72617", "species_10580002", "species_10579985" ], "modifiers": [ [ "species_72617", "catalyst" ] ], "additional_components": [ "DDB_G0286753", "Q75K16", "DDB_G0275459", "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "DDB_G0278205", "DDB_G0286753", "Q75K16", "DDB_G0275459", "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "DDB_G0278205" ] }, "reaction_10580394": { "compartment": "compartment_70101", "id": "reaction_10580394", "reactome": "R-DDI-72691", "name": "Formation of the 43S pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580390", "species_10580006" ], "products": [ "species_10580008" ], "modifiers": [], "additional_components": [ "Q54YJ6", "DDB_G0278205", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254" ] }, "reaction_10580076": { "compartment": "compartment_70101", "id": "reaction_10580076", "reactome": "R-DDI-72663", "name": "De novo formation of eIF2:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10580002" ], "products": [ "species_10580004" ], "modifiers": [], "additional_components": [ "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438" ] }, "reaction_10580078": { "compartment": "compartment_70101", "id": "reaction_10580078", "reactome": "R-DDI-72669", "name": "Met-tRNAi binds to eIF2:GTP to form the ternary complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_72393", "species_10580004" ], "products": [ "species_10580006" ], "modifiers": [ [ "species_29438", "catalyst" ] ], "additional_components": [ "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438" ] }, "reaction_10580384": { "compartment": "compartment_70101", "id": "reaction_10580384", "reactome": "R-DDI-72671", "name": "eIF5B:GTP is hydrolyzed and released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580378" ], "products": [ "species_10580382", "species_10580380", "species_29372" ], "modifiers": [], "additional_components": [ "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54XP6", "DDB_G0278815", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54XP6", "DDB_G0278815", "species_29420" ] }, "reaction_10580051": { "compartment": "compartment_70101", "id": "reaction_10580051", "reactome": "R-DDI-72619", "name": "eIF2:GTP is hydrolyzed, eIFs are released ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580045", "species_10580040", "species_72617" ], "products": [ "species_10580047", "species_10579980", "species_10580029", "species_10580045", "species_29372", "species_10580024", "species_10580038", "species_10580036", "species_10580019", "species_10579985", "species_10580049" ], "modifiers": [ [ "species_10580045", "catalyst" ] ], "additional_components": [ "DDB_G0286753", "Q75K16", "DDB_G0275459", "Q54YJ6", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "P90529", "DDB_G0269146", "Q55FE0", "DDB_G0268574", "Q553R3", "DDB_G0275395", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "DDB_G0275395", "DDB_G0286753", "DDB_G0268574", "DDB_G0275459", "DDB_G0275459", "P90529", "DDB_G0269146", "DDB_G0278205", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "species_29420", "DDB_G0286753" ] }, "reaction_10580386": { "compartment": "compartment_70101", "id": "reaction_10580386", "reactome": "R-DDI-72672", "name": "The 60S subunit joins the translation initiation complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580047", "species_10580367", "species_10580376" ], "products": [ "species_10580378" ], "modifiers": [], "additional_components": [ "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54XP6", "DDB_G0278815", "species_29438", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54XP6", "DDB_G0278815", "species_29438" ] }, "reaction_10580388": { "compartment": "compartment_70101", "id": "reaction_10580388", "reactome": "R-DDI-72673", "name": "Release of 40S and 60S subunits from the 80S ribosome ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10579985", "species_10580369" ], "products": [ "species_10580367", "species_10579913", "species_10579985" ], "modifiers": [], "additional_components": [ "DDB_G0278205", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "DDB_G0278205" ] }, "reaction_10580392": { "compartment": "compartment_70101", "id": "reaction_10580392", "reactome": "R-DDI-72676", "name": "eIF3 and eIF1A bind to the 40S subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10579980", "species_10579913", "species_10579985" ], "products": [ "species_10580390" ], "modifiers": [], "additional_components": [ "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "DDB_G0278205", "Q54YJ6", "DDB_G0278205", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54EQ1", "DDB_G0291404", "Q54QW1", "DDB_G0283597", "Q86LA2", "DDB_G0272076", "Q54UD0", "DDB_G0281153", "Q54KZ8", "DDB_G0287005", "Q86B20", "DDB_G0272078", "Q54KI0", "DDB_G0287333", "Q554U9", "DDB_G0274627", "Q54MT0", "DDB_G0285683", "Q54X97", "DDB_G0279109", "Q54WM4", "DDB_G0279549", "Q54CC5", "DDB_G0293052", "Q54C49", "DDB_G0293254" ] }, "reaction_10593013": { "compartment": "compartment_5460", "id": "reaction_10593013", "reactome": "R-DDI-449937", "name": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159450", "species_113521" ], "products": [ "species_113548" ], "modifiers": [ [ "species_10593010", "catalyst" ], [ "species_109496", "catalyst" ] ], "additional_components": [ "Q54PV8", "DDB_G0284265" ] }, "reaction_10578737": { "compartment": "compartment_70101", "id": "reaction_10578737", "reactome": "R-DDI-71732", "name": "pyrophosphate + H2O => 2 orthophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111294", "species_29356" ], "products": [ "species_29372" ], "modifiers": [ [ "species_10578734", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54PV8", "DDB_G0284265" ] }, "reaction_10601713": { "compartment": "compartment_7660", "id": "reaction_10601713", "reactome": "R-DDI-2993763", "name": "SENP1,2,5 proteolytically process SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601709" ], "products": [ "species_10601711" ], "modifiers": [ [ "species_10601673", "catalyst" ] ], "additional_components": [ "DDB_G0282161", "DDB_G0282161", "Q54DG4", "DDB_G0292290" ] }, "reaction_10601685": { "compartment": "compartment_7660", "id": "reaction_10601685", "reactome": "R-DDI-2990842", "name": "SENP1,2,5 proteolytically process SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601681" ], "products": [ "species_10601683" ], "modifiers": [ [ "species_10601673", "catalyst" ] ], "additional_components": [ "DDB_G0282161", "DDB_G0282161", "Q54DG4", "DDB_G0292290" ] }, "reaction_10601676": { "compartment": "compartment_7660", "id": "reaction_10601676", "reactome": "R-DDI-2990840", "name": "SENP1,2,5 proteolytically process SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601662" ], "products": [ "species_10594213" ], "modifiers": [ [ "species_10601673", "catalyst" ] ], "additional_components": [ "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q54DG4", "DDB_G0292290" ] }, "reaction_10601746": { "compartment": "compartment_7660", "id": "reaction_10601746", "reactome": "R-DDI-2993780", "name": "Transfer of SUMO1 from E1 to UBE2I (UBC9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601725", "species_10601653" ], "products": [ "species_10601743", "species_10601638" ], "modifiers": [ [ "species_10601638", "catalyst" ] ], "additional_components": [ "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54L40", "DDB_G0286919", "Q54WI4", "DDB_G0279641", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54L40", "DDB_G0286919", "Q54WI4", "DDB_G0279641", "Q54L40", "DDB_G0286919", "Q54WI4", "DDB_G0279641" ] }, "reaction_10601656": { "compartment": "compartment_7660", "id": "reaction_10601656", "reactome": "R-DDI-2990833", "name": "Conjugation of SUMO1 to UBA2:SAE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10601638", "species_10594213" ], "products": [ "species_164121", "species_10601653", "species_113541" ], "modifiers": [ [ "species_10601638", "catalyst" ] ], "additional_components": [ "Q54L40", "DDB_G0286919", "Q54WI4", "DDB_G0279641", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54L40", "DDB_G0286919", "Q54WI4", "DDB_G0279641", "Q54L40", "DDB_G0286919", "Q54WI4", "DDB_G0279641" ] }, "reaction_10603971": { "compartment": "compartment_7660", "id": "reaction_10603971", "reactome": "R-DDI-4570496", "name": "SUMOylation of Histone H4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10581418" ], "products": [ "species_10601725", "species_10603969" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0276863", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q76NW2", "DDB_G0276863", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10604098": { "compartment": "compartment_7660", "id": "reaction_10604098", "reactome": "R-DDI-4616015", "name": "SUMOylation of HDAC2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10603140" ], "products": [ "species_10601725", "species_10604096" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0268024", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q55FN5", "DDB_G0268024", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10604058": { "compartment": "compartment_7660", "id": "reaction_10604058", "reactome": "R-DDI-4615889", "name": "SUMOylation of HDAC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10597270" ], "products": [ "species_10601725", "species_10604056" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0268024", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q55FN5", "DDB_G0268024", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10603949": { "compartment": "compartment_7660", "id": "reaction_10603949", "reactome": "R-DDI-4570485", "name": "SUMOylation of Histone H4 with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581418", "species_10601799" ], "products": [ "species_10601725", "species_10603947" ], "modifiers": [ [ "species_10601799", "catalyst" ] ], "additional_components": [ "DDB_G0276863", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "DDB_G0276863", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161" ] }, "reaction_10603395": { "compartment": "compartment_7660", "id": "reaction_10603395", "reactome": "R-DDI-3900194", "name": "PIAS1 SUMOylates DDX5 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601786", "species_10579094" ], "products": [ "species_10601725", "species_10603392" ], "modifiers": [ [ "species_10594201", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q54SX2", "DDB_G0282161", "DDB_G0293168", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "DDB_G0293168", "Q54V57", "DDB_G0280603", "Q555X5", "DDB_G0274743" ] }, "reaction_10603490": { "compartment": "compartment_7660", "id": "reaction_10603490", "reactome": "R-DDI-4085992", "name": "SUMOylation of DAXX with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10602165" ], "products": [ "species_10601725", "species_10603488" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0279509", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54WP8", "DDB_G0279509", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10603511": { "compartment": "compartment_7660", "id": "reaction_10603511", "reactome": "R-DDI-4085994", "name": "TOPORS SUMOylates SIN3A with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10590689" ], "products": [ "species_10603503", "species_10601725" ], "modifiers": [ [ "species_10603508", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0281045", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54UJ3", "DDB_G0281045", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "DDB_G0281183" ] }, "reaction_10603528": { "compartment": "compartment_7660", "id": "reaction_10603528", "reactome": "R-DDI-4086083", "name": "SUMOylation of ING2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10603513" ], "products": [ "species_10601725", "species_10603526" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0284411", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54PN9", "DDB_G0284411", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10603563": { "compartment": "compartment_7660", "id": "reaction_10603563", "reactome": "R-DDI-4090284", "name": "SUMOylation of HIPK2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10603548" ], "products": [ "species_10601725", "species_10603561" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0283605", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q54QV3", "DDB_G0283605", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10603389": { "compartment": "compartment_7660", "id": "reaction_10603389", "reactome": "R-DDI-3900177", "name": "SUMOylation of DDX5 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10579094" ], "products": [ "species_10601725", "species_10603387" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0293168", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54CE0", "DDB_G0293168", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10603374": { "compartment": "compartment_7660", "id": "reaction_10603374", "reactome": "R-DDI-3900047", "name": "SUMOylation of DDX17 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10603354" ], "products": [ "species_10603372", "species_10601725" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54CB8", "DDB_G0293064", "Q54CE0", "DDB_G0293168", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q54CB8", "DDB_G0293064", "Q54CE0", "DDB_G0293168", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10604146": { "compartment": "compartment_7660", "id": "reaction_10604146", "reactome": "R-DDI-4641345", "name": "SUMOylation of TOP2B with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10604127" ], "products": [ "species_10601725", "species_10604144" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "P90520", "DDB_G0279737", "Q55BP5", "DDB_G0270418", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "P90520", "DDB_G0279737", "Q55BP5", "DDB_G0270418", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10604151": { "compartment": "compartment_7660", "id": "reaction_10604151", "reactome": "R-DDI-4641350", "name": "PIAS4 SUMOylates TOP2A with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601801", "species_10604103" ], "products": [ "species_10601725", "species_10604149" ], "modifiers": [ [ "species_10601810", "catalyst" ] ], "additional_components": [ "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161", "DDB_G0270418", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "DDB_G0270418", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10604118": { "compartment": "compartment_7660", "id": "reaction_10604118", "reactome": "R-DDI-4641342", "name": "SUMOylation of TOP2A with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10604103" ], "products": [ "species_10601725", "species_10604116" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0270418", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q55BP5", "DDB_G0270418", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10604075": { "compartment": "compartment_7660", "id": "reaction_10604075", "reactome": "R-DDI-4615910", "name": "SUMOylation of PCNA with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10577429" ], "products": [ "species_10601725", "species_10604073" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0287607", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q54K47", "DDB_G0287607", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10604171": { "compartment": "compartment_7660", "id": "reaction_10604171", "reactome": "R-DDI-4641362", "name": "SUMOylation of TOP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10604156" ], "products": [ "species_10601725", "species_10604169" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0283205", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54RC3", "DDB_G0283205", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10604001": { "compartment": "compartment_7660", "id": "reaction_10604001", "reactome": "R-DDI-4570553", "name": "SUMOylation of MDC1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603996", "species_10601801" ], "products": [ "species_10603999", "species_10601725" ], "modifiers": [ [ "species_10601801", "catalyst" ] ], "additional_components": [ "DDB_G0272690", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161", "DDB_G0272690", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161" ] }, "reaction_10603872": { "compartment": "compartment_7660", "id": "reaction_10603872", "reactome": "R-DDI-4568848", "name": "PIAS1,2-1 SUMOylates XRCC4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10603852" ], "products": [ "species_10601725", "species_10603865" ], "modifiers": [ [ "species_10603869", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0278203", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54YJ7", "DDB_G0278203", "Q54V57", "DDB_G0280603", "Q555X5", "DDB_G0274743" ] }, "reaction_10603847": { "compartment": "compartment_7660", "id": "reaction_10603847", "reactome": "R-DDI-4551768", "name": "PIAS4 SUMOylates PARP1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600664", "species_10601801" ], "products": [ "species_10601725", "species_10603845" ], "modifiers": [ [ "species_10601810", "catalyst" ] ], "additional_components": [ "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54HY5", "DDB_G0289141", "Q8I7C6", "DDB_G0292820", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10601830": { "compartment": "compartment_7660", "id": "reaction_10601830", "reactome": "R-DDI-2997709", "name": "PIAS1,4 SUMOylates BRCA1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10601773" ], "products": [ "species_10601725", "species_10601828" ], "modifiers": [ [ "species_10601812", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0293300", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q54C05", "DDB_G0293300", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10603718": { "compartment": "compartment_7660", "id": "reaction_10603718", "reactome": "R-DDI-4551604", "name": "PIAS4 SUMOylates PARP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10600664" ], "products": [ "species_10601725", "species_10603716" ], "modifiers": [ [ "species_10601810", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54HY5", "DDB_G0289141", "Q8I7C6", "DDB_G0292820", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10601901": { "compartment": "compartment_7660", "id": "reaction_10601901", "reactome": "R-DDI-3000383", "name": "UBE2I, HDAC7 SUMOylate PML with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10601869" ], "products": [ "species_10601884", "species_10601725" ], "modifiers": [ [ "species_10601898", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0285989", "Q54MF7", "DDB_G0285989", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54VQ7", "DDB_G0280195", "Q54X15", "DDB_G0279267", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153" ] }, "reaction_10602028": { "compartment": "compartment_7660", "id": "reaction_10602028", "reactome": "R-DDI-3108212", "name": "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10601093" ], "products": [ "species_10601725", "species_10601992" ], "modifiers": [ [ "species_10602025", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54QR0", "DDB_G0283681", "Q54E85", "DDB_G0291752", "Q552D9", "DDB_G0276101", "Q550H7", "DDB_G0276977", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54QR0", "DDB_G0283681", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q550H7", "DDB_G0276977", "Q54E85", "DDB_G0291752", "Q552D9", "DDB_G0276101", "Q54HN3", "DDB_G0289341", "Q54T56", "DDB_G0281991", "Q54FE3", "DDB_G0290919", "Q54PA3", "DDB_G0284679", "Q54X37", "DDB_G0279231", "Q54I56", "DDB_G0288993" ] }, "reaction_10603823": { "compartment": "compartment_7660", "id": "reaction_10603823", "reactome": "R-DDI-4551724", "name": "PIAS4 SUMOylates HERC2 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10603779" ], "products": [ "species_10601725", "species_10603821" ], "modifiers": [ [ "species_10601810", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54Q89", "DDB_G0284033", "Q8MP76", "DDB_G0284033", "Q54R64", "DDB_G0284033", "Q54S74", "DDB_G0284033", "Q54SA3", "DDB_G0284033", "Q54WU2", "DDB_G0284033", "Q55CR5", "DDB_G0284033", "Q55DD2", "DDB_G0284033", "B0G136", "DDB_G0284033", "Q55GN7", "DDB_G0284033", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54Q89", "DDB_G0284033", "Q55CR5", "DDB_G0284033", "Q55DD2", "DDB_G0284033", "Q54R64", "DDB_G0284033", "Q54S74", "DDB_G0284033", "Q55GN7", "DDB_G0284033", "Q8MP76", "DDB_G0284033", "Q54SA3", "DDB_G0284033", "Q54WU2", "DDB_G0284033", "B0G136", "DDB_G0284033", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10603889": { "compartment": "compartment_7660", "id": "reaction_10603889", "reactome": "R-DDI-4568863", "name": "SUMOylation of RAD52 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10581772" ], "products": [ "species_10603887", "species_10601725" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0269406", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q55E38", "DDB_G0269406", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10604016": { "compartment": "compartment_7660", "id": "reaction_10604016", "reactome": "R-DDI-4570554", "name": "SUMOylation of MDC1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10603996" ], "products": [ "species_10604014", "species_10601725" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0272690", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q86IG6", "DDB_G0272690", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10601815": { "compartment": "compartment_7660", "id": "reaction_10601815", "reactome": "R-DDI-2997616", "name": "PIAS1,4 SUMOylates BRCA1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601773", "species_10601801" ], "products": [ "species_10601804", "species_10601725" ], "modifiers": [ [ "species_10601812", "catalyst" ] ], "additional_components": [ "DDB_G0293300", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161", "DDB_G0293300", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10603991": { "compartment": "compartment_7660", "id": "reaction_10603991", "reactome": "R-DDI-4570528", "name": "SUMOylation of XPC with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10603976" ], "products": [ "species_10601725", "species_10603989" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0292296", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "Q1ZXA6", "DDB_G0292296", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10601914": { "compartment": "compartment_7660", "id": "reaction_10601914", "reactome": "R-DDI-3000433", "name": "SUMOylation of PML with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601869", "species_10601799" ], "products": [ "species_10601725", "species_10601911" ], "modifiers": [ [ "species_10601799", "catalyst" ] ], "additional_components": [ "DDB_G0285989", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "DDB_G0285989", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161" ] }, "reaction_10603903": { "compartment": "compartment_7660", "id": "reaction_10603903", "reactome": "R-DDI-4568914", "name": "SUMOylation of BLM with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601801", "species_10603894" ], "products": [ "species_10603900", "species_10601725" ], "modifiers": [ [ "species_10601801", "catalyst" ] ], "additional_components": [ "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161", "DDB_G0292130", "DDB_G0292130", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161" ] }, "reaction_10602897": { "compartment": "compartment_7660", "id": "reaction_10602897", "reactome": "R-DDI-3465545", "name": "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602878", "species_10601801" ], "products": [ "species_10601725", "species_10602886" ], "modifiers": [ [ "species_10602894", "catalyst" ] ], "additional_components": [ "Q1ZXA2", "DDB_G0293468", "Q54MS4", "DDB_G0285693", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54SX2", "DDB_G0282161", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q1ZXA2", "DDB_G0293468", "Q54MS4", "DDB_G0285693", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10601851": { "compartment": "compartment_7660", "id": "reaction_10601851", "reactome": "R-DDI-2997723", "name": "PIAS4 SUMOylates TP53BP1 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10601835" ], "products": [ "species_10601725", "species_10601848" ], "modifiers": [ [ "species_10601810", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0286539", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54LN0", "DDB_G0286539", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603" ] }, "reaction_10603474": { "compartment": "compartment_7660", "id": "reaction_10603474", "reactome": "R-DDI-4085350", "name": "SUMOylation of UBE2I with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10601725" ], "products": [ "species_10601725", "species_10603472" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10603446": { "compartment": "compartment_7660", "id": "reaction_10603446", "reactome": "R-DDI-3968362", "name": "SUMOylation of PIAS4 with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10601810" ], "products": [ "species_10601725", "species_10603444" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q555X5", "DDB_G0274743", "Q54V57", "DDB_G0280603", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10603757": { "compartment": "compartment_7660", "id": "reaction_10603757", "reactome": "R-DDI-4551683", "name": "SUMOylation of TOPORS with SUMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601743", "species_10603508" ], "products": [ "species_10601725", "species_10603755" ], "modifiers": [ [ "species_10601743", "catalyst" ] ], "additional_components": [ "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "DDB_G0281183", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54UA7", "DDB_G0281183", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189", "Q54KR7", "DDB_G0287153", "Q9NGP4", "DDB_G0287693", "Q55FZ7", "DDB_G0267886", "Q8N0B4", "DDB_G0286189" ] }, "reaction_10620075": { "compartment": "compartment_70101", "id": "reaction_10620075", "reactome": "R-DDI-8867370", "name": "TTLL3, TTLL8, TTLL10 polyglycylate tubulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589898", "species_113592", "species_29424" ], "products": [ "species_10620063", "species_29372", "species_29370" ], "modifiers": [ [ "species_10620072", "catalyst" ] ], "additional_components": [ "species_29438", "species_29420", "species_29438", "species_29420", "Q54TU1", "DDB_G0281541" ] }, "reaction_10623090": { "compartment": "compartment_70101", "id": "reaction_10623090", "reactome": "R-DDI-8938815", "name": "RNF152 polyubiquitinates RRAGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623077", "species_10623079" ], "products": [ "species_10623087", "species_10623070", "species_10587616" ], "modifiers": [ [ "species_10623079", "catalyst" ] ], "additional_components": [ "Q86K32", "DDB_G0277267", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54IK1", "DDB_G0288701", "species_29420", "Q86K32", "DDB_G0277267", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54L05", "DDB_G0286991", "species_29420", "Q54IK1", "DDB_G0288701", "DDB_G0286991", "DDB_G0277267", "Q54IK1", "DDB_G0288701", "species_29420", "Q86K32", "DDB_G0277267", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54L05", "DDB_G0286991" ] }, "reaction_10623282": { "compartment": "compartment_7660", "id": "reaction_10623282", "reactome": "R-DDI-8943007", "name": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623255", "species_10623270", "species_10623264", "species_10612435" ], "products": [ "species_10623272" ], "modifiers": [], "additional_components": [ "DDB_G0287171", "Q86K32", "DDB_G0277267", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54D06", "DDB_G0292596", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54KQ4", "DDB_G0287171" ] }, "reaction_10623906": { "compartment": "compartment_17947", "id": "reaction_10623906", "reactome": "R-DDI-8953917", "name": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623900", "species_10623902" ], "products": [ "species_10623904" ], "modifiers": [], "additional_components": [ "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54MD1", "DDB_G0286033", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54MD1", "DDB_G0286033" ] }, "reaction_10623280": { "compartment": "compartment_7660", "id": "reaction_10623280", "reactome": "R-DDI-8943003", "name": "SHPRH polyubiquitinates monoubiquitinated PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623272", "species_10623270" ], "products": [ "species_10623277", "species_10623255", "species_10623264", "species_10608545" ], "modifiers": [ [ "species_10623272", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54KQ4", "DDB_G0287171", "Q86K32", "DDB_G0277267", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54D06", "DDB_G0292596", "Q54K47", "DDB_G0287607", "DDB_G0287171", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54KQ4", "DDB_G0287171" ] }, "reaction_10623062": { "compartment": "compartment_70101", "id": "reaction_10623062", "reactome": "R-DDI-8938770", "name": "RNF144A binds PRKDC and Ubiquitin:UBE2L3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623047", "species_10623056", "species_10623058" ], "products": [ "species_10623060" ], "modifiers": [], "additional_components": [ "DDB_G0281167", "Q54ZG5", "DDB_G0277577", "Q54QC7", "DDB_G0283939", "Q54TE1", "DDB_G0281833", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54TE1", "DDB_G0281833", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54ZG5", "DDB_G0277577", "Q54QC7", "DDB_G0283939", "Q54UC0", "DDB_G0281167" ] }, "reaction_10623092": { "compartment": "compartment_70101", "id": "reaction_10623092", "reactome": "R-DDI-8938829", "name": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623070", "species_10623077", "species_10623072" ], "products": [ "species_10623079" ], "modifiers": [], "additional_components": [ "DDB_G0286991", "Q86K32", "DDB_G0277267", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54IK1", "DDB_G0288701", "species_29420", "Q54IK1", "DDB_G0288701", "species_29420", "Q86K32", "DDB_G0277267", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54L05", "DDB_G0286991" ] }, "reaction_10623306": { "compartment": "compartment_7660", "id": "reaction_10623306", "reactome": "R-DDI-8943041", "name": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623270", "species_10623264", "species_10612435", "species_10623299" ], "products": [ "species_10623301" ], "modifiers": [], "additional_components": [ "Q86K32", "DDB_G0277267", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54D06", "DDB_G0292596", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "Q54T24", "DDB_G0281949", "B0G105", "DDB_G0282115", "Q54SZ4", "DDB_G0282115", "Q54T24", "DDB_G0281949", "B0G105", "DDB_G0282115", "Q54SZ4", "DDB_G0282115", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596" ] }, "reaction_10623304": { "compartment": "compartment_7660", "id": "reaction_10623304", "reactome": "R-DDI-8943040", "name": "HLTF polyubiquitinates monoubiquitinated PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623301", "species_10623270" ], "products": [ "species_10623277", "species_10623264", "species_10623299", "species_10608545" ], "modifiers": [ [ "species_10623301", "catalyst" ] ], "additional_components": [ "Q54T24", "DDB_G0281949", "B0G105", "DDB_G0282115", "Q54SZ4", "DDB_G0282115", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q86K32", "DDB_G0277267", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54D06", "DDB_G0292596", "Q54K47", "DDB_G0287607", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q54T24", "DDB_G0281949", "B0G105", "DDB_G0282115", "Q54SZ4", "DDB_G0282115", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596", "Q54T24", "DDB_G0281949", "B0G105", "DDB_G0282115", "Q54SZ4", "DDB_G0282115", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "Q54XR0", "DDB_G0278935", "Q553F3", "DDB_G0275787", "Q86K32", "DDB_G0277267", "Q54D06", "DDB_G0292596" ] }, "reaction_10623068": { "compartment": "compartment_70101", "id": "reaction_10623068", "reactome": "R-DDI-8938773", "name": "RNF144A polyubiquitinates PRKDC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623060", "species_10623058" ], "products": [ "species_10596492", "species_10623065", "species_10623056" ], "modifiers": [ [ "species_10623060", "catalyst" ] ], "additional_components": [ "Q54TE1", "DDB_G0281833", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54ZG5", "DDB_G0277577", "Q54QC7", "DDB_G0283939", "Q54UC0", "DDB_G0281167", "Q54TE1", "DDB_G0281833", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0281833", "DDB_G0281167", "Q54ZG5", "DDB_G0277577", "Q54QC7", "DDB_G0283939", "Q54TE1", "DDB_G0281833", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54ZG5", "DDB_G0277577", "Q54QC7", "DDB_G0283939", "Q54UC0", "DDB_G0281167" ] }, "reaction_10623916": { "compartment": "compartment_17947", "id": "reaction_10623916", "reactome": "R-DDI-8953946", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623904" ], "products": [ "species_10623913", "species_10577361" ], "modifiers": [ [ "species_10623904", "catalyst" ] ], "additional_components": [ "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54MD1", "DDB_G0286033", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54MD1", "DDB_G0286033", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54MD1", "DDB_G0286033" ] }, "reaction_10619202": { "compartment": "compartment_70101", "id": "reaction_10619202", "reactome": "R-DDI-8853503", "name": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576913" ], "products": [ "species_10579845", "species_10576913" ], "modifiers": [ [ "species_10619199", "catalyst" ] ], "additional_components": [ "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "Q54T48", "DDB_G0282007", "Q869U4", "DDB_G0276443", "Q553T4", "DDB_G0275415" ] }, "reaction_10619233": { "compartment": "compartment_70101", "id": "reaction_10619233", "reactome": "R-DDI-8853515", "name": "OTULIN,USP5 cleaves UBC yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619230" ], "products": [ "species_10577007", "species_10577021", "species_10577035", "species_10576923", "species_10576937", "species_10576951", "species_10576965", "species_10576979", "species_10576993" ], "modifiers": [ [ "species_10610786", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG81", "DDB_G0279721", "P0CG80", "DDB_G0291928", "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "DDB_G0291239" ] }, "reaction_10619237": { "compartment": "compartment_70101", "id": "reaction_10619237", "reactome": "R-DDI-8853529", "name": "OTULIN,USP5 cleaves UBB yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619235" ], "products": [ "species_10576919", "species_10576917", "species_10576915" ], "modifiers": [ [ "species_10610786", "catalyst" ] ], "additional_components": [ "DDB_G0276765", "DDB_G0276765", "DDB_G0276765", "DDB_G0276765", "DDB_G0291239" ] }, "reaction_10619151": { "compartment": "compartment_7660", "id": "reaction_10619151", "reactome": "R-DDI-8852130", "name": "UBA1 conjugates ubiquitin to nuclear E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619115", "species_10619098" ], "products": [ "species_10619149", "species_10619064" ], "modifiers": [], "additional_components": [ "Q54TE1", "DDB_G0281833", "Q54XS6", "DDB_G0278775", "Q54I43", "DDB_G0289021", "Q54F00", "DDB_G0291199", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q55EY8", "DDB_G0268938", "Q553F3", "DDB_G0275787", "Q54VG3", "DDB_G0280347", "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG81", "DDB_G0279721", "P0CG80", "DDB_G0291928", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54I43", "DDB_G0289021", "Q553F3", "DDB_G0275787", "Q54TE1", "DDB_G0281833", "Q54F00", "DDB_G0291199", "Q54J12", "DDB_G0288697", "Q54IK3", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q55EY8", "DDB_G0268938", "Q54VG3", "DDB_G0280347", "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG81", "DDB_G0279721", "P0CG80", "DDB_G0291928", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272" ] }, "reaction_10618924": { "compartment": "compartment_70101", "id": "reaction_10618924", "reactome": "R-DDI-8852127", "name": "UBA6 conjugates ubiquitin to cytosolic E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618888", "species_10618890" ], "products": [ "species_10618892", "species_10618922" ], "modifiers": [], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG81", "DDB_G0279721", "P14797", "DDB_G0276765", "Q550P6", "DDB_G0277047", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q555G0", "DDB_G0274897", "Q54TE1", "DDB_G0281833", "Q54VG3", "DDB_G0280347", "Q54I43", "DDB_G0289021", "P0CG76", "DDB_G0282295", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG81", "DDB_G0279721", "P14797", "DDB_G0276765", "Q550P6", "DDB_G0277047", "Q54I43", "DDB_G0289021", "Q54TE1", "DDB_G0281833", "Q555G0", "DDB_G0274897", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "Q54VG3", "DDB_G0280347", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765" ] }, "reaction_10619216": { "compartment": "compartment_70101", "id": "reaction_10619216", "reactome": "R-DDI-8853514", "name": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619214" ], "products": [ "species_10580280", "species_10576913" ], "modifiers": [ [ "species_10619199", "catalyst" ] ], "additional_components": [ "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG81", "DDB_G0279721", "P0CG80", "DDB_G0291928", "P0CG88", "DDB_G0269458", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "Q54T48", "DDB_G0282007", "Q869U4", "DDB_G0276443", "Q553T4", "DDB_G0275415" ] }, "reaction_10619153": { "compartment": "compartment_7660", "id": "reaction_10619153", "reactome": "R-DDI-8852131", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10619096", "species_10576865" ], "products": [ "species_10619098", "species_113541" ], "modifiers": [], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG81", "DDB_G0279721", "P0CG80", "DDB_G0291928", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272" ] }, "reaction_10619094": { "compartment": "compartment_70101", "id": "reaction_10619094", "reactome": "R-DDI-8852129", "name": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619068", "species_10619072" ], "products": [ "species_10619092", "species_10619074" ], "modifiers": [], "additional_components": [ "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54XS6", "DDB_G0278775", "Q54VW9", "DDB_G0280091", "Q54VG3", "DDB_G0280347", "Q75JE1", "DDB_G0271726", "Q54TE1", "DDB_G0281833", "Q54I43", "DDB_G0289021", "P0CG76", "DDB_G0282295", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG81", "DDB_G0279721", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272", "Q54I43", "DDB_G0289021", "Q54TE1", "DDB_G0281833", "Q54VG3", "DDB_G0280347", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "Q75JE1", "DDB_G0271726", "Q54XS6", "DDB_G0278775", "Q54VW9", "DDB_G0280091", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG81", "DDB_G0279721", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272" ] }, "reaction_10619159": { "compartment": "compartment_70101", "id": "reaction_10619159", "reactome": "R-DDI-8852133", "name": "UBA1 conjugates ubiquitin to UBA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619074" ], "products": [ "species_10619070", "species_76577" ], "modifiers": [ [ "species_10619074", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG81", "DDB_G0279721", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272", "Q55C16", "DDB_G0270272", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG81", "DDB_G0279721", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272" ] }, "reaction_10619156": { "compartment": "compartment_70101", "id": "reaction_10619156", "reactome": "R-DDI-8852132", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619070", "species_10577037", "species_113592" ], "products": [ "species_111294", "species_10619072" ], "modifiers": [ [ "species_10619070", "catalyst" ] ], "additional_components": [ "Q55C16", "DDB_G0270272", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG81", "DDB_G0279721", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272", "Q55C16", "DDB_G0270272", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765" ] }, "reaction_10619162": { "compartment": "compartment_70101", "id": "reaction_10619162", "reactome": "R-DDI-8852134", "name": "UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_113592", "species_10596583" ], "products": [ "species_111294", "species_10619074" ], "modifiers": [ [ "species_10596583", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0270272", "P0CG76", "DDB_G0282295", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG80", "DDB_G0291928", "P0CG79", "DDB_G0282369", "P0CG81", "DDB_G0279721", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272", "DDB_G0270272" ] }, "reaction_10619066": { "compartment": "compartment_7660", "id": "reaction_10619066", "reactome": "R-DDI-8852128", "name": "UBA1 adenylates ubiquitin in the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10618926", "species_10576865" ], "products": [ "species_10619064", "species_113541" ], "modifiers": [], "additional_components": [ "DDB_G0270272", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG81", "DDB_G0279721", "P0CG80", "DDB_G0291928", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272" ] }, "reaction_10619164": { "compartment": "compartment_7660", "id": "reaction_10619164", "reactome": "R-DDI-8852136", "name": "UBA1 conjugates ubiquitin to UBA1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619064" ], "products": [ "species_164121", "species_10619096" ], "modifiers": [], "additional_components": [ "P0CG88", "DDB_G0269458", "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P0CG78", "DDB_G0289449", "P0CG81", "DDB_G0279721", "P0CG80", "DDB_G0291928", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55C16", "DDB_G0270272" ] }, "reaction_10594387": { "compartment": "compartment_17963", "id": "reaction_10594387", "reactome": "R-DDI-914005", "name": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10594356" ], "products": [ "species_205687", "species_10594385" ], "modifiers": [], "additional_components": [ "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357", "Q54ZU4", "DDB_G0277357", "Q54KS2", "DDB_G0287193" ] }, "reaction_10594407": { "compartment": "compartment_17963", "id": "reaction_10594407", "reactome": "R-DDI-914008", "name": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10594356" ], "products": [ "species_205687", "species_10594405" ], "modifiers": [], "additional_components": [ "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357", "Q54ZU4", "DDB_G0277357", "Q54KS2", "DDB_G0287193" ] }, "reaction_10594441": { "compartment": "compartment_17963", "id": "reaction_10594441", "reactome": "R-DDI-914017", "name": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10594356" ], "products": [ "species_10594439", "species_205687" ], "modifiers": [], "additional_components": [ "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357", "Q54ZU4", "DDB_G0277357", "Q54KS2", "DDB_G0287193" ] }, "reaction_10594397": { "compartment": "compartment_17963", "id": "reaction_10594397", "reactome": "R-DDI-914006", "name": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10594356" ], "products": [ "species_10594395", "species_205687" ], "modifiers": [], "additional_components": [ "Q54KS2", "DDB_G0287193", "Q54ZU4", "DDB_G0277357", "Q54ZU4", "DDB_G0277357", "Q54KS2", "DDB_G0287193" ] }, "reaction_10603666": { "compartment": "compartment_12045", "id": "reaction_10603666", "reactome": "R-DDI-4419978", "name": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362", "species_4419987" ], "products": [ "species_4419982" ], "modifiers": [ [ "species_10603663", "catalyst" ] ], "additional_components": [ "Q54EN3", "DDB_G0291436", "Q55AK1", "DDB_G0271830" ] }, "reaction_10603674": { "compartment": "compartment_12045", "id": "reaction_10603674", "reactome": "R-DDI-4419979", "name": "SRD5A3 reduces pPNOL to DCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_4419981", "species_29364" ], "products": [ "species_29366", "species_449221" ], "modifiers": [ [ "species_10603671", "catalyst" ] ], "additional_components": [ "DDB_G0284423" ] }, "reaction_10592733": { "compartment": "compartment_12045", "id": "reaction_10592733", "reactome": "R-DDI-446195", "name": "DOLK phosphorylates DCHOL to DOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_449221" ], "products": [ "species_110094", "species_449299" ], "modifiers": [ [ "species_10592730", "catalyst" ] ], "additional_components": [ "DDB_G0285689" ] }, "reaction_10592749": { "compartment": "compartment_12045", "id": "reaction_10592749", "reactome": "R-DDI-446200", "name": "DOLPP1 dephosphorylates DOLDP to DOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_449744" ], "products": [ "species_29372", "species_449299" ], "modifiers": [ [ "species_10592746", "catalyst" ] ], "additional_components": [ "DDB_G0274591" ] }, "reaction_10592768": { "compartment": "compartment_70101", "id": "reaction_10592768", "reactome": "R-DDI-446201", "name": "PMM1,2 isomerise Man6P to Man1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_532562" ], "products": [ "species_532531" ], "modifiers": [ [ "species_10592765", "catalyst" ] ], "additional_components": [ "Q54X03", "DDB_G0279289", "Q86B09", "DDB_G0272781" ] }, "reaction_10593934": { "compartment": "compartment_70101", "id": "reaction_10593934", "reactome": "R-DDI-532549", "name": "MPI isomerises Fru6P to Man6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512" ], "products": [ "species_532562" ], "modifiers": [ [ "species_10593931", "catalyst" ] ], "additional_components": [ "DDB_G0284685" ] }, "reaction_10592802": { "compartment": "compartment_12045", "id": "reaction_10592802", "reactome": "R-DDI-446214", "name": "Synthesis of dolichyl-phosphate-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449299", "species_29410" ], "products": [ "species_532214", "species_110096" ], "modifiers": [ [ "species_10592799", "catalyst" ] ], "additional_components": [ "DDB_G0288321" ] }, "reaction_10591655": { "compartment": "compartment_17938", "id": "reaction_10591655", "reactome": "R-DDI-428585", "name": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428040", "species_428639" ], "products": [ "species_428633", "species_70106" ], "modifiers": [ [ "species_10591652", "catalyst" ] ], "additional_components": [ "DDB_G0280761" ] }, "reaction_10612709": { "compartment": "compartment_70101", "id": "reaction_10612709", "reactome": "R-DDI-6787540", "name": "FUK phosphorylates beta-Fuc to Fuc1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6787678" ], "products": [ "species_29370", "species_6787542" ], "modifiers": [ [ "species_10612706", "catalyst" ] ], "additional_components": [ "DDB_G0269678" ] }, "reaction_10612727": { "compartment": "compartment_70101", "id": "reaction_10612727", "reactome": "R-DDI-6787632", "name": "GMDS dehydrates GDP-Man to GDP-DHDMan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860" ], "products": [ "species_29356", "species_6787618" ], "modifiers": [ [ "species_10612724", "catalyst" ] ], "additional_components": [ "DDB_G0284553" ] }, "reaction_10594121": { "compartment": "compartment_20699", "id": "reaction_10594121", "reactome": "R-DDI-742345", "name": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742368" ], "products": [ "species_205683" ], "modifiers": [ [ "species_10594118", "catalyst" ] ], "additional_components": [ "DDB_G0277007" ] }, "reaction_10612730": { "compartment": "compartment_70101", "id": "reaction_10612730", "reactome": "R-DDI-6787642", "name": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_6787646", "species_29364" ], "products": [ "species_742368", "species_29366" ], "modifiers": [ [ "species_10612716", "catalyst" ] ], "additional_components": [ "Q55C77", "DDB_G0270184" ] }, "reaction_10612701": { "compartment": "compartment_70101", "id": "reaction_10612701", "reactome": "R-DDI-6787533", "name": "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_6787542" ], "products": [ "species_111294", "species_742368" ], "modifiers": [ [ "species_10612698", "catalyst" ] ], "additional_components": [ "DDB_G0285257" ] }, "reaction_10612719": { "compartment": "compartment_70101", "id": "reaction_10612719", "reactome": "R-DDI-6787623", "name": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787618" ], "products": [ "species_6787646" ], "modifiers": [ [ "species_10612716", "catalyst" ] ], "additional_components": [ "Q55C77", "DDB_G0270184" ] }, "reaction_10592786": { "compartment": "compartment_70101", "id": "reaction_10592786", "reactome": "R-DDI-446204", "name": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29494", "species_532204" ], "products": [ "species_111294", "species_162756" ], "modifiers": [ [ "species_10592783", "catalyst" ] ], "additional_components": [ "Q54GN5", "DDB_G0290055" ] }, "reaction_10593001": { "compartment": "compartment_70101", "id": "reaction_10593001", "reactome": "R-DDI-449734", "name": "Acetylation of glucosamine 6-phosphate to GlcNAc6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183", "species_449701" ], "products": [ "species_76194", "species_449703" ], "modifiers": [ [ "species_10592998", "catalyst" ] ], "additional_components": [ "Q54WR8", "DDB_G0279475" ] }, "reaction_10592991": { "compartment": "compartment_70101", "id": "reaction_10592991", "reactome": "R-DDI-449715", "name": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512", "species_29472" ], "products": [ "species_29404", "species_449701" ], "modifiers": [ [ "species_10592988", "catalyst" ] ], "additional_components": [ "Q54LK1", "DDB_G0286603" ] }, "reaction_10592725": { "compartment": "compartment_12045", "id": "reaction_10592725", "reactome": "R-DDI-446191", "name": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162756", "species_449299" ], "products": [ "species_109402", "species_449222" ], "modifiers": [ [ "species_10592722", "catalyst" ] ], "additional_components": [ "DDB_G0290751" ] }, "reaction_10592741": { "compartment": "compartment_17957", "id": "reaction_10592741", "reactome": "R-DDI-446198", "name": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449312" ], "products": [ "species_449311", "species_449365" ], "modifiers": [ [ "species_10592738", "catalyst" ], [ "species_10592706", "catalyst" ] ], "additional_components": [ "DDB_G0267884", "DDB_G0295677" ] }, "reaction_10592820": { "compartment": "compartment_12045", "id": "reaction_10592820", "reactome": "R-DDI-446218", "name": "Addition of the first mannose to the N-glycan precursor by ALG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449293" ], "products": [ "species_29420", "species_449283" ], "modifiers": [ [ "species_10592817", "catalyst" ] ], "additional_components": [ "DDB_G0286011" ] }, "reaction_10592708": { "compartment": "compartment_17957", "id": "reaction_10592708", "reactome": "R-DDI-446188", "name": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449298" ], "products": [ "species_449311", "species_449315" ], "modifiers": [ [ "species_10592700", "catalyst" ], [ "species_10592706", "catalyst" ] ], "additional_components": [ "DDB_G0268238", "DDB_G0295677" ] }, "reaction_10592776": { "compartment": "compartment_17957", "id": "reaction_10592776", "reactome": "R-DDI-446202", "name": "Addition of the first glucose to the N-glycan precursor by ALG6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449371", "species_532542" ], "products": [ "species_449311", "species_449649" ], "modifiers": [ [ "species_10592773", "catalyst" ] ], "additional_components": [ "DDB_G0283841" ] }, "reaction_10592794": { "compartment": "compartment_12045", "id": "reaction_10592794", "reactome": "R-DDI-446208", "name": "Addition of a second mannose to the N-glycan precursor by ALG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449283" ], "products": [ "species_449737", "species_29420" ], "modifiers": [ [ "species_10592791", "catalyst" ] ], "additional_components": [ "DDB_G0272730" ] }, "reaction_10592810": { "compartment": "compartment_17957", "id": "reaction_10592810", "reactome": "R-DDI-446215", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449315" ], "products": [ "species_449311", "species_449312" ], "modifiers": [ [ "species_10592807", "catalyst" ], [ "species_10592706", "catalyst" ] ], "additional_components": [ "DDB_G0279349", "DDB_G0295677" ] }, "reaction_10592717": { "compartment": "compartment_17957", "id": "reaction_10592717", "reactome": "R-DDI-446189", "name": "Addition of a second glucose to the N-glycan precursor by ALG8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449649", "species_532542" ], "products": [ "species_449311", "species_449638" ], "modifiers": [ [ "species_10592714", "catalyst" ] ], "additional_components": [ "DDB_G0275261" ] }, "reaction_10592812": { "compartment": "compartment_17957", "id": "reaction_10592812", "reactome": "R-DDI-446216", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449365" ], "products": [ "species_449371", "species_449311" ], "modifiers": [ [ "species_10592807", "catalyst" ], [ "species_10592706", "catalyst" ] ], "additional_components": [ "DDB_G0279349", "DDB_G0295677" ] }, "reaction_10619185": { "compartment": "compartment_70101", "id": "reaction_10619185", "reactome": "R-DDI-8853379", "name": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10596971" ], "products": [ "species_8853371", "species_8853381" ], "modifiers": [ [ "species_10619182", "catalyst" ] ], "additional_components": [ "CHEBI:60627", "CHEBI:60628", "species_915149", "CHEBI:60629", "species_964740", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "species_8853396", "species_6799540", "CHEBI:91283", "CHEBI:91282", "CHEBI:91281", "DDB_G0268520" ] }, "reaction_10596973": { "compartment": "compartment_70101", "id": "reaction_10596973", "reactome": "R-DDI-1022127", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596969" ], "products": [ "species_10596971" ], "modifiers": [], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "CHEBI:60627", "CHEBI:60628", "species_915149", "CHEBI:60629", "species_964740", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765" ] }, "reaction_10594300": { "compartment": "compartment_17957", "id": "reaction_10594300", "reactome": "R-DDI-901047", "name": "Binding of ERp57", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594296", "species_10594000" ], "products": [ "species_10594298" ], "modifiers": [], "additional_components": [ "CHEBI:59080", "Q55BA8", "DDB_G0271144", "Q23858", "DDB_G0283539", "DDB_G0291434", "Q54EN4", "DDB_G0291434", "CHEBI:59080", "Q55BA8", "DDB_G0271144", "Q23858", "DDB_G0283539" ] }, "reaction_10595778": { "compartment": "compartment_20699", "id": "reaction_10595778", "reactome": "R-DDI-975814", "name": "Trimming of mannoses on the alpha1,6 arm by MAN2A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964837" ], "products": [ "species_964752", "species_975819" ], "modifiers": [ [ "species_10595775", "catalyst" ] ], "additional_components": [ "Q54KN4", "DDB_G0287231", "species_29426" ] }, "reaction_10596981": { "compartment": "compartment_20699", "id": "reaction_10596981", "reactome": "R-DDI-1028788", "name": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975910", "species_205683" ], "products": [ "species_205689", "species_1028779" ], "modifiers": [ [ "species_10596978", "catalyst" ] ], "additional_components": [ "DDB_G0278473" ] }, "reaction_10611509": { "compartment": "compartment_17963", "id": "reaction_10611509", "reactome": "R-DDI-5693925", "name": "FUT3 transfers L-fucose to Gal1,3GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693930", "species_205683" ], "products": [ "species_5693933", "species_205689" ], "modifiers": [ [ "species_10611506", "catalyst" ] ], "additional_components": [ "Q54PK0", "DDB_G0284775", "Q86J24", "DDB_G0284775", "Q54P60", "DDB_G0284775", "Q54PH9", "DDB_G0284467", "Q54PK3", "DDB_G0284551", "Q54RA6", "DDB_G0284775", "Q54PJ9", "DDB_G0284775" ] }, "reaction_10611469": { "compartment": "compartment_161320", "id": "reaction_10611469", "reactome": "R-DDI-5693807", "name": "FUCA1 hydrolyses NGP:1,6-GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_6784247" ], "products": [ "species_6784248", "species_6784249" ], "modifiers": [ [ "species_10611466", "catalyst" ] ], "additional_components": [ "P10901", "DDB_G0274391", "Q551C1", "DDB_G0276661" ] }, "reaction_10595786": { "compartment": "compartment_17963", "id": "reaction_10595786", "reactome": "R-DDI-975926", "name": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_975910" ], "products": [ "species_981613" ], "modifiers": [ [ "species_10595783", "catalyst" ] ], "additional_components": [ "DDB_G0272422" ] }, "reaction_10620710": { "compartment": "compartment_70101", "id": "reaction_10620710", "reactome": "R-DDI-8870457", "name": "FarC-PTP4A2 binds RABGGTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620704", "species_10620706" ], "products": [ "species_10620708" ], "modifiers": [], "additional_components": [ "Q54DU9", "DDB_G0292024", "Q86IL4", "DDB_G0292024", "DDB_G0290671", "B0G172", "DDB_G0290671", "Q54DU9", "DDB_G0292024", "Q86IL4", "DDB_G0292024" ] }, "reaction_10620725": { "compartment": "compartment_70101", "id": "reaction_10620725", "reactome": "R-DDI-8870465", "name": "RGGT binds the RAB-binding subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1131164", "species_10620714", "species_10620721" ], "products": [ "species_10620723" ], "modifiers": [], "additional_components": [ "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "Q54VT9", "DDB_G0280143", "Q54VT9", "DDB_G0280143", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "species_1131164" ] }, "reaction_10621957": { "compartment": "compartment_70101", "id": "reaction_10621957", "reactome": "R-DDI-8870469", "name": "RGGT geranylgeranylates RAB proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1131164", "species_10621130" ], "products": [ "species_1132084", "species_10621952", "species_10621954" ], "modifiers": [ [ "species_10621130", "catalyst" ] ], "additional_components": [ "Q54VT9", "DDB_G0280143", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "species_1131164", "Q86JP3", "DDB_G0271984", "Q54RY4", "DDB_G0282899", "P20790", "DDB_G0280043", "Q1ZXE7", "DDB_G0286169", "P20791", "DDB_G0276399", "P36409", "DDB_G0292268", "Q8MXQ2", "DDB_G0275675", "Q1ZXC0", "DDB_G0290827", "Q54QR3", "DDB_G0283603", "P36412", "DDB_G0269238", "P34139", "DDB_G0283757", "Q86JP0", "DDB_G0294583", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "species_29420", "Q54VT9", "DDB_G0280143", "species_29420", "Q8MXQ2", "DDB_G0275675", "Q1ZXC0", "DDB_G0290827", "Q54QR3", "DDB_G0283603", "P34139", "DDB_G0283757", "P36412", "DDB_G0269238", "P34143", "DDB_G0271736", "Q558I0", "DDB_G0272905", "Q54EW9", "DDB_G0291293", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "Q54NU2", "DDB_G0284985", "P34141", "DDB_G0291233", "Q552K3", "DDB_G0275969", "P36409", "DDB_G0292268", "Q86JP0", "DDB_G0294583", "Q1ZXE7", "DDB_G0286169", "P20791", "DDB_G0276399", "Q54RY4", "DDB_G0282899", "P20790", "DDB_G0280043", "Q86JP3", "DDB_G0271984", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "species_1131164", "Q54VT9", "DDB_G0280143", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "species_1131164", "Q86JP3", "DDB_G0271984", "Q54RY4", "DDB_G0282899", "P20790", "DDB_G0280043", "Q1ZXE7", "DDB_G0286169", "P20791", "DDB_G0276399", "P36409", "DDB_G0292268", "Q8MXQ2", "DDB_G0275675", "Q1ZXC0", "DDB_G0290827", "Q54QR3", "DDB_G0283603", "P36412", "DDB_G0269238", "P34139", "DDB_G0283757", "Q86JP0", "DDB_G0294583", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "species_29420" ] }, "reaction_10620716": { "compartment": "compartment_70101", "id": "reaction_10620716", "reactome": "R-DDI-8870461", "name": "RABGGTA and RABGGTB bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620712", "species_10620706" ], "products": [ "species_10620714" ], "modifiers": [ [ "species_10620708", "inhibitor" ] ], "additional_components": [ "DDB_G0269570", "DDB_G0290671", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "B0G172", "DDB_G0290671", "Q54DU9", "DDB_G0292024", "Q86IL4", "DDB_G0292024" ] }, "reaction_10621132": { "compartment": "compartment_70101", "id": "reaction_10621132", "reactome": "R-DDI-8870466", "name": "RGGT:CHM binds RABs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10621128", "species_10620723" ], "products": [ "species_10621130" ], "modifiers": [], "additional_components": [ "Q86JP3", "DDB_G0271984", "Q54RY4", "DDB_G0282899", "P20790", "DDB_G0280043", "Q1ZXE7", "DDB_G0286169", "P20791", "DDB_G0276399", "P36409", "DDB_G0292268", "Q8MXQ2", "DDB_G0275675", "Q1ZXC0", "DDB_G0290827", "Q54QR3", "DDB_G0283603", "P36412", "DDB_G0269238", "P34139", "DDB_G0283757", "Q86JP0", "DDB_G0294583", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "species_29420", "Q54VT9", "DDB_G0280143", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "species_1131164", "Q54VT9", "DDB_G0280143", "B0G172", "DDB_G0290671", "Q55DQ4", "DDB_G0269570", "species_1131164", "Q86JP3", "DDB_G0271984", "Q54RY4", "DDB_G0282899", "P20790", "DDB_G0280043", "Q1ZXE7", "DDB_G0286169", "P20791", "DDB_G0276399", "P36409", "DDB_G0292268", "Q8MXQ2", "DDB_G0275675", "Q1ZXC0", "DDB_G0290827", "Q54QR3", "DDB_G0283603", "P36412", "DDB_G0269238", "P34139", "DDB_G0283757", "Q86JP0", "DDB_G0294583", "P34141", "DDB_G0291233", "P34143", "DDB_G0271736", "Q54EW9", "DDB_G0291293", "Q54NU2", "DDB_G0284985", "Q552K3", "DDB_G0275969", "Q558I0", "DDB_G0272905", "Q7KWT0", "DDB_G0276295", "P34140", "DDB_G0277867", "species_29420" ] }, "reaction_10583985": { "compartment": "compartment_70101", "id": "reaction_10583985", "reactome": "R-DDI-162857", "name": "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855657", "species_29356" ], "products": [ "species_8855661", "species_29416" ], "modifiers": [ [ "species_10583982", "catalyst" ] ], "additional_components": [ "DDB_G0293136" ] }, "reaction_10583923": { "compartment": "compartment_70101", "id": "reaction_10583923", "reactome": "R-DDI-162730", "name": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426639", "species_162756" ], "products": [ "species_8855657", "species_110096" ], "modifiers": [ [ "species_10583920", "catalyst" ] ], "additional_components": [ "Q86K35", "DDB_G0277289", "Q86JM6", "DDB_G0272006", "Q556K9", "DDB_G0272588", "Q54QB2", "DDB_G0283965", "Q54M40", "DDB_G0286221", "Q54WP5", "DDB_G0279515" ] }, "reaction_10583954": { "compartment": "compartment_12045", "id": "reaction_10583954", "reactome": "R-DDI-162798", "name": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855659", "species_1500581" ], "products": [ "species_8855663", "species_1500596" ], "modifiers": [ [ "species_10583951", "catalyst" ] ], "additional_components": [ "DDB_G0279313" ] }, "reaction_10583938": { "compartment": "compartment_12045", "id": "reaction_10583938", "reactome": "R-DDI-162742", "name": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855660" ], "products": [ "species_8855660" ], "modifiers": [ [ "species_10583935", "catalyst" ] ], "additional_components": [ "Q54PB0", "DDB_G0284667", "Q551Y7", "DDB_G0276251" ] }, "reaction_10583977": { "compartment": "compartment_12045", "id": "reaction_10583977", "reactome": "R-DDI-162830", "name": "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_8855665" ], "products": [ "species_8855659", "species_162872" ], "modifiers": [ [ "species_10583974", "catalyst" ] ], "additional_components": [ "Q54QP2", "DDB_G0283717", "Q54IA4", "DDB_G0288899" ] }, "reaction_10583993": { "compartment": "compartment_12045", "id": "reaction_10583993", "reactome": "R-DDI-162873", "name": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_8855663" ], "products": [ "species_162872", "species_8855667" ], "modifiers": [ [ "species_10583990", "catalyst" ] ], "additional_components": [ "DDB_G0280891" ] }, "reaction_10583962": { "compartment": "compartment_12045", "id": "reaction_10583962", "reactome": "R-DDI-162821", "name": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_8855667" ], "products": [ "species_8855656", "species_162872" ], "modifiers": [ [ "species_10583959", "catalyst" ] ], "additional_components": [ "DDB_G0284435" ] }, "reaction_10583946": { "compartment": "compartment_12045", "id": "reaction_10583946", "reactome": "R-DDI-162797", "name": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855656", "species_449229" ], "products": [ "species_8855664" ], "modifiers": [ [ "species_10583943", "catalyst" ] ], "additional_components": [ "DDB_G0291660" ] }, "reaction_10583871": { "compartment": "compartment_17957", "id": "reaction_10583871", "reactome": "R-DDI-162683", "name": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_8855661" ], "products": [ "species_8855666", "species_76194" ], "modifiers": [ [ "species_10583868", "catalyst" ] ], "additional_components": [ "DDB_G0286111" ] }, "reaction_10623183": { "compartment": "compartment_984", "id": "reaction_10623183", "reactome": "R-DDI-8940388", "name": "GPLD1 hydrolyses GPI-anchors from proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10623153" ], "products": [ "species_10623175", "species_2197633" ], "modifiers": [ [ "species_10623180", "catalyst" ] ], "additional_components": [ "Q55E77", "DDB_G0270488", "Q54WG1", "DDB_G0279675", "Q54I77", "DDB_G0288963", "Q54G06", "DDB_G0290501", "Q54WG1", "DDB_G0279675", "Q55E77", "DDB_G0270488", "Q54I77", "DDB_G0288963", "Q54G06", "DDB_G0290501", "DDB_G0276919" ] }, "reaction_10605201": { "compartment": "compartment_70101", "id": "reaction_10605201", "reactome": "R-DDI-5358475", "name": "DPH6 ligates ammonium to diphthine-EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10605193", "species_31633" ], "products": [ "species_111294", "species_10583767", "species_76577" ], "modifiers": [ [ "species_10605198", "catalyst" ] ], "additional_components": [ "DDB_G0288373", "DDB_G0288373", "DDB_G0278373" ] }, "reaction_10605237": { "compartment": "compartment_70101", "id": "reaction_10605237", "reactome": "R-DDI-5358494", "name": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10605217" ], "products": [ "species_353106", "species_10605204" ], "modifiers": [ [ "species_10605234", "catalyst" ] ], "additional_components": [ "DDB_G0288373", "DDB_G0288373", "Q7KWL8", "DDB_G0277061", "Q54PW5", "DDB_G0284257", "B0G132", "DDB_G0295687" ] }, "reaction_10605215": { "compartment": "compartment_70101", "id": "reaction_10605215", "reactome": "R-DDI-5358484", "name": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10605204" ], "products": [ "species_10605207", "species_71285" ], "modifiers": [ [ "species_10605212", "catalyst" ] ], "additional_components": [ "DDB_G0288373", "DDB_G0288373", "DDB_G0276115" ] }, "reaction_10612822": { "compartment": "compartment_12045", "id": "reaction_10612822", "reactome": "R-DDI-6788650", "name": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788753", "species_71284" ], "products": [ "species_71285", "species_6788758" ], "modifiers": [ [ "species_10612819", "catalyst" ] ], "additional_components": [ "Q558K8", "DDB_G0272799", "species_29426" ] }, "reaction_10588135": { "compartment": "compartment_70101", "id": "reaction_10588135", "reactome": "R-DDI-204662", "name": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_10588102", "species_73473" ], "products": [ "species_29356", "species_10588123", "species_29360" ], "modifiers": [ [ "species_10588132", "catalyst" ] ], "additional_components": [ "DDB_G0284861", "DDB_G0284861", "Q556G4", "DDB_G0272634", "species_71067" ] }, "reaction_10588118": { "compartment": "compartment_70101", "id": "reaction_10588118", "reactome": "R-DDI-204617", "name": "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_204628", "species_10588102", "species_73473" ], "products": [ "species_10588106", "species_204635", "species_29360" ], "modifiers": [ [ "species_10588115", "catalyst" ] ], "additional_components": [ "DDB_G0284861", "DDB_G0284861", "Q54MQ7", "DDB_G0285725" ] }, "reaction_10621975": { "compartment": "compartment_70101", "id": "reaction_10621975", "reactome": "R-DDI-8873946", "name": "OTUD3 deubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10621972" ], "products": [ "species_10587224" ], "modifiers": [ [ "species_10616721", "catalyst" ] ], "additional_components": [ "DDB_G0286557", "DDB_G0286557", "DDB_G0267906" ] }, "reaction_10612360": { "compartment": "compartment_70101", "id": "reaction_10612360", "reactome": "R-DDI-6781953", "name": "YOD1 binds VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605038", "species_10612356" ], "products": [ "species_10612358" ], "modifiers": [], "additional_components": [ "DDB_G0288065", "DDB_G0271346", "Q55BI3", "DDB_G0271346", "P90532", "DDB_G0288065" ] }, "reaction_10611237": { "compartment": "compartment_7660", "id": "reaction_10611237", "reactome": "R-DDI-5691381", "name": "MYSM1 deubiquitinates Histone H2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10611232" ], "products": [ "species_10611234", "species_10576865" ], "modifiers": [ [ "species_10611232", "catalyst" ] ], "additional_components": [ "Q54R05", "DDB_G0283459", "Q54J55", "DDB_G0288285", "Q550R6", "DDB_G0277033", "Q54R05", "DDB_G0283459", "Q54J55", "DDB_G0288285", "Q550R6", "DDB_G0277033", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R05", "DDB_G0283459", "Q54J55", "DDB_G0288285", "Q550R6", "DDB_G0277033" ] }, "reaction_10611958": { "compartment": "compartment_70101", "id": "reaction_10611958", "reactome": "R-DDI-5696547", "name": "STAMBPL1 is a deubiquitinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584754" ], "products": [ "species_10584752" ], "modifiers": [ [ "species_10611955", "catalyst" ] ], "additional_components": [ "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "DDB_G0284037" ] }, "reaction_10611240": { "compartment": "compartment_70101", "id": "reaction_10611240", "reactome": "R-DDI-5691431", "name": "PSMD14 cleaves K63-linked ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584754" ], "products": [ "species_10584752" ], "modifiers": [ [ "species_10577042", "catalyst" ] ], "additional_components": [ "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "DDB_G0272566" ] }, "reaction_10612001": { "compartment": "compartment_70101", "id": "reaction_10612001", "reactome": "R-DDI-5696600", "name": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10611992" ], "products": [ "species_10611998", "species_10609754" ], "modifiers": [ [ "species_10611992", "catalyst" ] ], "additional_components": [ "Q54QM6", "DDB_G0283617", "Q86L44", "DDB_G0294407", "Q86J16", "DDB_G0274827", "Q86J16", "DDB_G0274827", "Q86L44", "DDB_G0294407", "Q54QM6", "DDB_G0283617", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54QM6", "DDB_G0283617", "Q86L44", "DDB_G0294407", "Q86J16", "DDB_G0274827" ] }, "reaction_10610823": { "compartment": "compartment_7660", "id": "reaction_10610823", "reactome": "R-DDI-5690157", "name": "USP16,USP21 deubiquitinate Histone H2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10610818" ], "products": [ "species_10610820", "species_10576865" ], "modifiers": [ [ "species_10610818", "catalyst" ] ], "additional_components": [ "Q55EJ1", "DDB_G0268872", "Q86KB3", "DDB_G0274207", "Q55EJ1", "DDB_G0268872", "Q86KB3", "DDB_G0274207", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55EJ1", "DDB_G0268872", "Q86KB3", "DDB_G0274207" ] }, "reaction_10609766": { "compartment": "compartment_70101", "id": "reaction_10609766", "reactome": "R-DDI-5689539", "name": "ADRM1:26S proteaseome binds USP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606645", "species_10609762" ], "products": [ "species_10609764" ], "modifiers": [], "additional_components": [ "Q556N5", "DDB_G0272624", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408", "DDB_G0271264", "Q55BC4", "DDB_G0271264", "Q556N5", "DDB_G0272624", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10610793": { "compartment": "compartment_70101", "id": "reaction_10610793", "reactome": "R-DDI-5690152", "name": "USP5 cleaves polyubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10610788" ], "products": [ "species_10577037", "species_10610790" ], "modifiers": [ [ "species_10610788", "catalyst" ] ], "additional_components": [ "P54201", "DDB_G0291239", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P54201", "DDB_G0291239", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P54201", "DDB_G0291239", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295" ] }, "reaction_10612299": { "compartment": "compartment_70101", "id": "reaction_10612299", "reactome": "R-DDI-6781814", "name": "USP19 deubiquitinates RNF123", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10612294" ], "products": [ "species_10612296", "species_10584754" ], "modifiers": [ [ "species_10612294", "catalyst" ] ], "additional_components": [ "B0G199", "DDB_G0293770", "Q54PQ7", "DDB_G0293770", "Q54N05", "DDB_G0285581", "B0G199", "DDB_G0293770", "Q54PQ7", "DDB_G0293770", "Q54N05", "DDB_G0285581", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "B0G199", "DDB_G0293770", "Q54PQ7", "DDB_G0293770", "Q54N05", "DDB_G0285581" ] }, "reaction_10611978": { "compartment": "compartment_70101", "id": "reaction_10611978", "reactome": "R-DDI-5696564", "name": "USP25 deubiquitinates DDX58", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611966", "species_29356" ], "products": [ "species_10609754", "species_10611968" ], "modifiers": [ [ "species_10611966", "catalyst" ] ], "additional_components": [ "Q54DT4", "DDB_G0292046", "Q553T4", "DDB_G0275415", "Q86L44", "DDB_G0294407", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q86L44", "DDB_G0294407", "Q54DT4", "DDB_G0292046", "Q553T4", "DDB_G0275415", "Q54DT4", "DDB_G0292046", "Q553T4", "DDB_G0275415", "Q86L44", "DDB_G0294407" ] }, "reaction_10612202": { "compartment": "compartment_7660", "id": "reaction_10612202", "reactome": "R-DDI-5696958", "name": "USP44 deubiquitinates CDC20", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10612197" ], "products": [ "species_10610745", "species_10612199" ], "modifiers": [ [ "species_10612197", "catalyst" ] ], "additional_components": [ "Q54MZ3", "DDB_G0285601", "Q55EJ1", "DDB_G0268872", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55EJ1", "DDB_G0268872", "Q54MZ3", "DDB_G0285601", "Q54MZ3", "DDB_G0285601", "Q55EJ1", "DDB_G0268872" ] }, "reaction_10612234": { "compartment": "compartment_7660", "id": "reaction_10612234", "reactome": "R-DDI-5696960", "name": "USP49 deubiquitinates H2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10612229" ], "products": [ "species_10612231", "species_10576865" ], "modifiers": [ [ "species_10612229", "catalyst" ] ], "additional_components": [ "Q55EJ1", "DDB_G0268872", "Q55EJ1", "DDB_G0268872", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55EJ1", "DDB_G0268872" ] }, "reaction_10620654": { "compartment": "compartment_70101", "id": "reaction_10620654", "reactome": "R-DDI-8869456", "name": "USP4 deubiquitinate TRAF2,TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10620649" ], "products": [ "species_10609754", "species_10620651" ], "modifiers": [ [ "species_10611973", "catalyst" ] ], "additional_components": [ "B0G199", "DDB_G0293770", "Q54FB9", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54YP8", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "DDB_G0293770" ] }, "reaction_10612268": { "compartment": "compartment_7660", "id": "reaction_10612268", "reactome": "R-DDI-5697009", "name": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10612261" ], "products": [ "species_10610745", "species_10612265" ], "modifiers": [ [ "species_10612261", "catalyst" ] ], "additional_components": [ "Q54C28", "DDB_G0293226", "P34124", "DDB_G0292382", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54C28", "DDB_G0293226", "P34124", "DDB_G0292382", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "Q54C28", "DDB_G0293226", "P34124", "DDB_G0292382", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493" ] }, "reaction_10612468": { "compartment": "compartment_7660", "id": "reaction_10612468", "reactome": "R-DDI-6782820", "name": "USP17 deubiquitinates SUDS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10612463" ], "products": [ "species_10610329", "species_10612465" ], "modifiers": [ [ "species_10612463", "catalyst" ] ], "additional_components": [ "Q86J16", "DDB_G0274827", "Q54PU3", "DDB_G0284289", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54PU3", "DDB_G0284289", "Q86J16", "DDB_G0274827", "Q86J16", "DDB_G0274827", "Q54PU3", "DDB_G0284289" ] }, "reaction_10612280": { "compartment": "compartment_70101", "id": "reaction_10612280", "reactome": "R-DDI-6781779", "name": "USP13 deubiquitinates BECN1,USP10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10612275" ], "products": [ "species_10612277", "species_10584754" ], "modifiers": [ [ "species_10612275", "catalyst" ] ], "additional_components": [ "Q54JI9", "DDB_G0288021", "P54201", "DDB_G0291239", "Q54JI9", "DDB_G0288021", "P54201", "DDB_G0291239", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54JI9", "DDB_G0288021", "P54201", "DDB_G0291239" ] }, "reaction_10612155": { "compartment": "compartment_70101", "id": "reaction_10612155", "reactome": "R-DDI-5696627", "name": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10612104" ], "products": [ "species_10612152", "species_10584754" ], "modifiers": [ [ "species_10612104", "catalyst" ] ], "additional_components": [ "Q54XX5", "DDB_G0278535", "Q54FC5", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "P11467", "DDB_G0290961", "Q1ZXR0", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54ZW5", "DDB_G0277345", "Q86AY4", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q557K2", "DDB_G0293202", "P11467", "DDB_G0290961", "Q54FG0", "DDB_G0293202", "Q1ZXR0", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "Q54FC5", "DDB_G0293202", "Q54XX5", "DDB_G0278535", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54XX5", "DDB_G0278535", "Q54FC5", "DDB_G0293202", "Q55GA0", "DDB_G0293202", "Q55GA8", "DDB_G0293202", "Q54FD5", "DDB_G0293202", "Q54FG0", "DDB_G0293202", "Q86AY4", "DDB_G0293202", "Q86K46", "DDB_G0293202", "Q54IP3", "DDB_G0293202", "Q54NN4", "DDB_G0293202", "Q86KX6", "DDB_G0293202", "Q86L54", "DDB_G0293202", "Q54WD3", "DDB_G0293202", "Q54YP8", "DDB_G0293202", "P11467", "DDB_G0290961", "Q1ZXR0", "DDB_G0293202", "Q557K0", "DDB_G0293202", "Q557K2", "DDB_G0293202", "Q54C11", "DDB_G0293202", "Q54F79", "DDB_G0293202", "Q559R2", "DDB_G0293202", "Q55A66", "DDB_G0293202", "Q54FB9", "DDB_G0293202", "Q54ZW5", "DDB_G0277345" ] }, "reaction_10610842": { "compartment": "compartment_70101", "id": "reaction_10610842", "reactome": "R-DDI-5690159", "name": "USP21 deubiquitinates RIPK1,DDX58", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10610835" ], "products": [ "species_10609754", "species_10610839" ], "modifiers": [ [ "species_10610835", "catalyst" ] ], "additional_components": [ "Q54XX5", "DDB_G0278535", "Q86L44", "DDB_G0294407", "Q55EJ1", "DDB_G0268872", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54XX5", "DDB_G0278535", "Q86L44", "DDB_G0294407", "Q55EJ1", "DDB_G0268872", "Q54XX5", "DDB_G0278535", "Q86L44", "DDB_G0294407", "Q55EJ1", "DDB_G0268872" ] }, "reaction_10612029": { "compartment": "compartment_7660", "id": "reaction_10612029", "reactome": "R-DDI-5696605", "name": "USP12, USP26 deubiquitinate AR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10612022" ], "products": [ "species_10612026", "species_10610745" ], "modifiers": [ [ "species_10612022", "catalyst" ] ], "additional_components": [ "Q54ZP5", "DDB_G0277533", "Q54G37", "DDB_G0290453", "Q54UB2", "DDB_G0281319", "Q54ZP5", "DDB_G0277533", "Q54G37", "DDB_G0290453", "Q54UB2", "DDB_G0281319", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54ZP5", "DDB_G0277533", "Q54G37", "DDB_G0290453", "Q54UB2", "DDB_G0281319" ] }, "reaction_10610748": { "compartment": "compartment_7660", "id": "reaction_10610748", "reactome": "R-DDI-5689950", "name": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10609773" ], "products": [ "species_10610745", "species_10609777" ], "modifiers": [ [ "species_10609773", "catalyst" ] ], "additional_components": [ "Q8T9S7", "DDB_G0286557", "Q869U4", "DDB_G0276443", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q869U4", "DDB_G0276443", "Q8T9S7", "DDB_G0286557", "Q8T9S7", "DDB_G0286557", "Q869U4", "DDB_G0276443" ] }, "reaction_10595007": { "compartment": "compartment_70101", "id": "reaction_10595007", "reactome": "R-DDI-936390", "name": "CYLD mediated deubiquitination of DDX58 (RIG-I)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10595000" ], "products": [ "species_10577037", "species_10595002" ], "modifiers": [ [ "species_10595004", "catalyst" ] ], "additional_components": [ "DDB_G0294407", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0294407", "DDB_G0277345" ] }, "reaction_10609757": { "compartment": "compartment_70101", "id": "reaction_10609757", "reactome": "R-DDI-5689111", "name": "PARK2 autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10609754", "species_10596322" ], "products": [ "species_10608777" ], "modifiers": [ [ "species_10596322", "catalyst" ] ], "additional_components": [ "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54I29", "DDB_G0289043", "Q54I29", "DDB_G0289043", "Q8T2Q2", "DDB_G0289043", "Q54IL3", "DDB_G0289043", "Q54XG4", "DDB_G0289043" ] }, "reaction_10608751": { "compartment": "compartment_70101", "id": "reaction_10608751", "reactome": "R-DDI-5688797", "name": "ATXN3 family cleave Ub chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10584754" ], "products": [ "species_10584754", "species_10584752" ], "modifiers": [ [ "species_10608748", "catalyst" ] ], "additional_components": [ "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "Q55DI9", "DDB_G0269646" ] }, "reaction_10590032": { "compartment": "compartment_12045", "id": "reaction_10590032", "reactome": "R-DDI-381109", "name": "IRE1 binds IRE1 forming dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590020" ], "products": [ "species_10590022" ], "modifiers": [], "additional_components": [ "DDB_G0267650", "Q55GJ2", "DDB_G0267650" ] }, "reaction_10590030": { "compartment": "compartment_12045", "id": "reaction_10590030", "reactome": "R-DDI-381091", "name": "IRE1 dimer autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10590022" ], "products": [ "species_10590027", "species_29370" ], "modifiers": [ [ "species_10590022", "catalyst" ] ], "additional_components": [ "Q55GJ2", "DDB_G0267650", "Q55GJ2", "DDB_G0267650", "Q55GJ2", "DDB_G0267650" ] }, "reaction_10590082": { "compartment": "compartment_12045", "id": "reaction_10590082", "reactome": "R-DDI-381186", "name": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590078" ], "products": [ "species_10590052" ], "modifiers": [], "additional_components": [ "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023" ] }, "reaction_10590886": { "compartment": "compartment_20699", "id": "reaction_10590886", "reactome": "R-DDI-420818", "name": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590058" ], "products": [ "species_10590878", "species_10589991" ], "modifiers": [ [ "species_10590883", "catalyst" ] ], "additional_components": [ "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "DDB_G0275939" ] }, "reaction_10590072": { "compartment": "compartment_20699", "id": "reaction_10590072", "reactome": "R-DDI-381135", "name": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590052" ], "products": [ "species_10590058", "species_10590064" ], "modifiers": [ [ "species_10590069", "catalyst" ] ], "additional_components": [ "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023", "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "DDB_G0282397" ] }, "reaction_10589999": { "compartment": "compartment_70101", "id": "reaction_10589999", "reactome": "R-DDI-381026", "name": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589991" ], "products": [ "species_10589997" ], "modifiers": [], "additional_components": [ "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439", "Q54Q90", "DDB_G0284023", "Q54WU0", "DDB_G0279439" ] }, "reaction_10590040": { "compartment": "compartment_70101", "id": "reaction_10590040", "reactome": "R-DDI-381111", "name": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10580002" ], "products": [ "species_29370", "species_10590037" ], "modifiers": [ [ "species_10590013", "catalyst" ] ], "additional_components": [ "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "Q54R98", "DDB_G0283301" ] }, "reaction_10590015": { "compartment": "compartment_12045", "id": "reaction_10590015", "reactome": "R-DDI-381087", "name": "Dimerization of PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590004" ], "products": [ "species_10590013" ], "modifiers": [], "additional_components": [ "DDB_G0283301", "Q54R98", "DDB_G0283301" ] }, "reaction_10577620": { "compartment": "compartment_7660", "id": "reaction_10577620", "reactome": "R-DDI-69608", "name": "Phosphorylation of Cdc25A at Ser-123 by Chk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10577539" ], "products": [ "species_10577598", "species_113582" ], "modifiers": [ [ "species_10577617", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "DDB_G0280321" ] }, "reaction_10577608": { "compartment": "compartment_7660", "id": "reaction_10577608", "reactome": "R-DDI-69604", "name": "Phosphorylation of Cdc25A at Ser-123 by Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10577539" ], "products": [ "species_10577598", "species_113582" ], "modifiers": [ [ "species_10577605", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "DDB_G0279719" ] }, "reaction_10577596": { "compartment": "compartment_70101", "id": "reaction_10577596", "reactome": "R-DDI-69600", "name": "Proteolytic degradation of ubiquitinated-Cdc25A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577594" ], "products": [ "species_10577037" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q54QM6", "DDB_G0283617", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10626291": { "compartment": "compartment_161320", "id": "reaction_10626291", "reactome": "R-DDI-9638076", "name": "HEXB cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162223", "species_1605715" ], "products": [ "species_1678743", "species_2162224" ], "modifiers": [ [ "species_10598378", "catalyst" ] ], "additional_components": [ "P13723", "DDB_G0287033" ] }, "reaction_10600527": { "compartment": "compartment_161320", "id": "reaction_10600527", "reactome": "R-DDI-2162225", "name": "HEXA cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162223", "species_1605715" ], "products": [ "species_1678743", "species_2162224" ], "modifiers": [ [ "species_10598376", "catalyst" ] ], "additional_components": [ "Q54K55", "DDB_G0287597", "Q54SC9", "DDB_G0282539", "Q54K56", "DDB_G0287659", "Q54MU9", "DDB_G0285647", "P13723", "DDB_G0287033" ] }, "reaction_10612384": { "compartment": "compartment_7660", "id": "reaction_10612384", "reactome": "R-DDI-6782069", "name": "UVSSA:USP7 deubiquitinates ERCC6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10612375" ], "products": [ "species_10612381", "species_10576865" ], "modifiers": [ [ "species_10612375", "catalyst" ] ], "additional_components": [ "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54TY2", "DDB_G0281441", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54TY2", "DDB_G0281441", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54TY2", "DDB_G0281441", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10612308": { "compartment": "compartment_7660", "id": "reaction_10612308", "reactome": "R-DDI-6781824", "name": "Active RNA Pol II complex transcribes lesion-containing DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612301", "species_6781829" ], "products": [ "species_113541", "species_10612305" ], "modifiers": [ [ "species_10612301", "catalyst" ] ], "additional_components": [ "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729" ] }, "reaction_10612328": { "compartment": "compartment_7660", "id": "reaction_10612328", "reactome": "R-DDI-6781833", "name": "ERCC8 (CSA) binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612315", "species_10612324" ], "products": [ "species_10611193", "species_10612326" ], "modifiers": [], "additional_components": [ "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54TY2", "DDB_G0281441", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54PF3", "DDB_G0284597", "Q54QX3", "DDB_G0283587", "Q54HL6", "DDB_G0289361", "Q55BD5", "DDB_G0271282", "Q54E53", "DDB_G0291848", "Q54C92", "DDB_G0293180", "Q75K24", "DDB_G0275471", "Q54B82", "DDB_G0293844", "Q54PF3", "DDB_G0284597", "Q54QX3", "DDB_G0283587", "Q54HL6", "DDB_G0289361", "Q55BD5", "DDB_G0271282", "Q54E53", "DDB_G0291848", "Q54C92", "DDB_G0293180", "Q75K24", "DDB_G0275471", "Q54B82", "DDB_G0293844", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54TY2", "DDB_G0281441" ] }, "reaction_10612330": { "compartment": "compartment_7660", "id": "reaction_10612330", "reactome": "R-DDI-6781840", "name": "ERCC6 binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612313", "species_10612305" ], "products": [ "species_10612315" ], "modifiers": [], "additional_components": [ "DDB_G0281441", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54TY2", "DDB_G0281441" ] }, "reaction_10612349": { "compartment": "compartment_7660", "id": "reaction_10612349", "reactome": "R-DDI-6781867", "name": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612326", "species_10576865" ], "products": [ "species_10612346" ], "modifiers": [ [ "species_10612326", "catalyst" ] ], "additional_components": [ "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54TY2", "DDB_G0281441", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54TY2", "DDB_G0281441", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54TY2", "DDB_G0281441" ] }, "reaction_10612303": { "compartment": "compartment_7660", "id": "reaction_10612303", "reactome": "R-DDI-6781818", "name": "RNA Pol II initiates transcription from damaged DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580699", "species_10578887", "species_5688114" ], "products": [ "species_10612301" ], "modifiers": [], "additional_components": [ "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729" ] }, "reaction_10590490": { "compartment": "compartment_70101", "id": "reaction_10590490", "reactome": "R-DDI-390329", "name": "Dephosphorylation of AKT by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10586959", "species_29356" ], "products": [ "species_29372", "species_10590487" ], "modifiers": [ [ "species_10590274", "catalyst" ] ], "additional_components": [ "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795" ] }, "reaction_10624161": { "compartment": "compartment_984", "id": "reaction_10624161", "reactome": "R-DDI-8979996", "name": "LIPs hydrolyze TG to DAG and LCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10624158", "catalyst" ] ], "additional_components": [] }, "reaction_10591551": { "compartment": "compartment_876", "id": "reaction_10591551", "reactome": "R-DDI-427998", "name": "Proton-coupled di- and tri-peptide cotransport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_428037" ], "products": [ "species_428026", "species_70106" ], "modifiers": [ [ "species_10591548", "catalyst" ] ], "additional_components": [ "CHEBI:90799", "CHEBI:47923", "CHEBI:47923", "CHEBI:90799", "DDB_G0267874" ] }, "reaction_10581636": { "compartment": "compartment_7660", "id": "reaction_10581636", "reactome": "R-DDI-75861", "name": "NTP Binds Active Site of RNA Polymerase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581630", "species_30595" ], "products": [ "species_10581634" ], "modifiers": [], "additional_components": [ "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "species_110614", "species_113592", "species_29494", "species_29438", "species_110614", "species_113592", "species_29494", "species_29438", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617" ] }, "reaction_10581644": { "compartment": "compartment_7660", "id": "reaction_10581644", "reactome": "R-DDI-75864", "name": "Newly Formed Phosphodiester Bond Stabilized and PPi Released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581642" ], "products": [ "species_10580924", "species_113541" ], "modifiers": [], "additional_components": [ "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617" ] }, "reaction_10581646": { "compartment": "compartment_7660", "id": "reaction_10581646", "reactome": "R-DDI-75866", "name": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581634" ], "products": [ "species_10581642" ], "modifiers": [], "additional_components": [ "species_110614", "species_113592", "species_29494", "species_29438", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617" ] }, "reaction_10581767": { "compartment": "compartment_7660", "id": "reaction_10581767", "reactome": "R-DDI-75949", "name": "RNA Polymerase II Promoter Opening: First Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10581638" ], "products": [ "species_113550", "species_113582", "species_10581630" ], "modifiers": [ [ "species_10580699", "catalyst" ] ], "additional_components": [ "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54FD6", "DDB_G0290929", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729" ] }, "reaction_10581650": { "compartment": "compartment_7660", "id": "reaction_10581650", "reactome": "R-DDI-75869", "name": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581608", "species_30595" ], "products": [ "species_10580844", "species_113541", "species_10581648" ], "modifiers": [ [ "species_10578889", "catalyst" ] ], "additional_components": [ "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "species_110614", "species_113592", "species_29494", "species_29438", "DDB_G0290929", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10626119": { "compartment": "compartment_7660", "id": "reaction_10626119", "reactome": "R-DDI-9613494", "name": "Unwinding of DNA for the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10581608" ], "products": [ "species_164121", "species_10581608", "species_113541" ], "modifiers": [ [ "species_10580699", "catalyst" ] ], "additional_components": [ "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729" ] }, "reaction_10581611": { "compartment": "compartment_7660", "id": "reaction_10581611", "reactome": "R-DDI-75850", "name": "Addition of the third nucleotide on the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580924", "species_30595" ], "products": [ "species_10581608", "species_113541" ], "modifiers": [ [ "species_10578889", "catalyst" ] ], "additional_components": [ "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "species_110614", "species_113592", "species_29494", "species_29438", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10626121": { "compartment": "compartment_7660", "id": "reaction_10626121", "reactome": "R-DDI-9613497", "name": "Unwinding DNA for the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580924", "species_30595" ], "products": [ "species_10580924", "species_113541" ], "modifiers": [ [ "species_10580699", "catalyst" ] ], "additional_components": [ "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "species_110614", "species_113592", "species_29494", "species_29438", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729" ] }, "reaction_10582826": { "compartment": "compartment_7660", "id": "reaction_10582826", "reactome": "R-DDI-111264", "name": "Addition of nucleotides between position +11 and +30", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582331", "species_30595" ], "products": [ "species_113541", "species_10582368" ], "modifiers": [ [ "species_10578889", "catalyst" ] ], "additional_components": [ "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "species_110614", "species_113592", "species_29494", "species_29438", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10582333": { "compartment": "compartment_7660", "id": "reaction_10582333", "reactome": "R-DDI-76576", "name": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581677", "species_30595" ], "products": [ "species_10582331", "species_113541" ], "modifiers": [ [ "species_10578889", "catalyst" ] ], "additional_components": [ "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "species_110614", "species_113592", "species_29494", "species_29438", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10581679": { "compartment": "compartment_7660", "id": "reaction_10581679", "reactome": "R-DDI-75873", "name": "Addition of Nucleotides 5 through 9 on the growing Transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10581648" ], "products": [ "species_10580910", "species_10581677", "species_10580922", "species_10580839", "species_113541" ], "modifiers": [ [ "species_10578889", "catalyst" ] ], "additional_components": [ "species_110614", "species_113592", "species_29494", "species_29438", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10590450": { "compartment": "compartment_17951", "id": "reaction_10590450", "reactome": "R-DDI-389986", "name": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_389894" ], "products": [ "species_389982" ], "modifiers": [ [ "species_10586623", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10590437": { "compartment": "compartment_17951", "id": "reaction_10590437", "reactome": "R-DDI-389889", "name": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389893" ], "products": [ "species_113575", "species_389894" ], "modifiers": [ [ "species_10590434", "catalyst" ] ], "additional_components": [ "species_113596", "Q54LF1", "DDB_G0286669", "Q54GQ6", "DDB_G0289993" ] }, "reaction_10590452": { "compartment": "compartment_17951", "id": "reaction_10590452", "reactome": "R-DDI-389995", "name": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389982", "species_192307" ], "products": [ "species_193465", "species_389996", "species_192305" ], "modifiers": [ [ "species_10586623", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10590447": { "compartment": "compartment_17951", "id": "reaction_10590447", "reactome": "R-DDI-389891", "name": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389893" ], "products": [ "species_113575", "species_389894" ], "modifiers": [ [ "species_10590444", "catalyst" ] ], "additional_components": [ "species_113596", "Q8MMS1", "DDB_G0277477" ] }, "reaction_10619972": { "compartment": "compartment_7660", "id": "reaction_10619972", "reactome": "R-DDI-8866601", "name": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_8866574" ], "products": [ "species_8866608", "species_8866567" ], "modifiers": [ [ "species_10619969", "catalyst" ], [ "species_29892", "catalyst" ] ], "additional_components": [ "B0G107", "DDB_G0272484", "species_29426" ] }, "reaction_10601235": { "compartment": "compartment_70101", "id": "reaction_10601235", "reactome": "R-DDI-2509827", "name": "ITPA hydrolyses ITP to IMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2509836" ], "products": [ "species_111294", "species_29602" ], "modifiers": [ [ "species_10601232", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54LQ6", "DDB_G0286495" ] }, "reaction_10581202": { "compartment": "compartment_70101", "id": "reaction_10581202", "reactome": "R-DDI-74247", "name": "Hypoxanthine + H2O + O2 => Xanthine + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113599", "species_29356", "species_29368" ], "products": [ "species_29408", "species_30064" ], "modifiers": [ [ "species_10581199", "catalyst" ] ], "additional_components": [ "CHEBI:44074", "species_113596", "Q54FB7", "DDB_G0291047" ] }, "reaction_10581222": { "compartment": "compartment_70101", "id": "reaction_10581222", "reactome": "R-DDI-74255", "name": "Guanine + H2O => Xanthine + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_83956" ], "products": [ "species_31633", "species_30064" ], "modifiers": [ [ "species_10581219", "catalyst" ] ], "additional_components": [ "Q86AW9", "DDB_G0277743", "species_29426" ] }, "reaction_10601238": { "compartment": "compartment_70101", "id": "reaction_10601238", "reactome": "R-DDI-2509831", "name": "ITPA hydrolyses XTP to XMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509848", "species_29356" ], "products": [ "species_111294", "species_111584" ], "modifiers": [ [ "species_10601232", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54LQ6", "DDB_G0286495" ] }, "reaction_10601241": { "compartment": "compartment_70101", "id": "reaction_10601241", "reactome": "R-DDI-2509838", "name": "ITPA hydrolyses dITP to dIMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509835", "species_29356" ], "products": [ "species_111294", "species_109330" ], "modifiers": [ [ "species_10601232", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54LQ6", "DDB_G0286495" ] }, "reaction_10581224": { "compartment": "compartment_70101", "id": "reaction_10581224", "reactome": "R-DDI-74258", "name": "Xanthine + H2O + O2 => Urate + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29368", "species_30064" ], "products": [ "species_30034", "species_29408" ], "modifiers": [ [ "species_10581199", "catalyst" ] ], "additional_components": [ "CHEBI:44074", "species_113596", "Q54FB7", "DDB_G0291047" ] }, "reaction_10581212": { "compartment": "compartment_70101", "id": "reaction_10581212", "reactome": "R-DDI-74248", "name": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500120", "species_29356" ], "products": [ "species_29372", "species_500118" ], "modifiers": [ [ "species_10581209", "catalyst" ] ], "additional_components": [ "species_29602", "species_109330", "species_113578", "CHEBI:16192", "CHEBI:17172", "CHEBI:28997", "species_83921", "CHEBI:16750", "Q54XC1", "DDB_G0279053", "species_29926" ] }, "reaction_10612835": { "compartment": "compartment_7660", "id": "reaction_10612835", "reactome": "R-DDI-6788810", "name": "AK6 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_6788813" ], "products": [ "species_113582", "species_6788807" ], "modifiers": [ [ "species_10612832", "catalyst" ] ], "additional_components": [ "CHEBI:15918", "species_109395", "species_76577", "species_109386", "species_110094", "CHEBI:16174", "CHEBI:28846", "species_29370", "DDB_G0278493" ] }, "reaction_10582661": { "compartment": "compartment_70101", "id": "reaction_10582661", "reactome": "R-DDI-110137", "name": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_6788782" ], "products": [ "species_6788778", "species_113592" ], "modifiers": [ [ "species_10582658", "catalyst" ] ], "additional_components": [ "species_29370", "CHEBI:28846", "CHEBI:16174", "species_110094", "species_76577", "species_109395", "CHEBI:15918", "species_109386", "Q54CT8", "DDB_G0292730", "Q54QJ9", "DDB_G0283805" ] }, "reaction_10582663": { "compartment": "compartment_70101", "id": "reaction_10582663", "reactome": "R-DDI-110138", "name": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788778", "species_113592" ], "products": [ "species_29370", "species_6788782" ], "modifiers": [ [ "species_10582658", "catalyst" ] ], "additional_components": [ "species_76577", "species_109395", "CHEBI:15918", "species_109386", "species_29370", "CHEBI:28846", "CHEBI:16174", "species_110094", "Q54CT8", "DDB_G0292730", "Q54QJ9", "DDB_G0283805" ] }, "reaction_10580715": { "compartment": "compartment_70101", "id": "reaction_10580715", "reactome": "R-DDI-73788", "name": "(d)GMP + ATP <=> (d)GDP + ADP (GUK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500071" ], "products": [ "species_29370", "species_500077" ], "modifiers": [ [ "species_10580712", "catalyst" ] ], "additional_components": [ "species_113578", "CHEBI:16192", "species_29420", "CHEBI:28862", "DDB_G0279001" ] }, "reaction_10580555": { "compartment": "compartment_70101", "id": "reaction_10580555", "reactome": "R-DDI-73635", "name": "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_499997", "species_113592" ], "products": [ "species_29370", "species_499999" ], "modifiers": [ [ "species_10580552", "catalyst" ] ], "additional_components": [ "species_500742", "species_109366", "CHEBI:28850", "CHEBI:18075", "Q54GN2", "DDB_G0290033" ] }, "reaction_10593837": { "compartment": "compartment_5460", "id": "reaction_10593837", "reactome": "R-DDI-482804", "name": "(d)NDP + ATP <=> (d)NTP + ADP (NME4)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_482803" ], "products": [ "species_113581", "species_482807" ], "modifiers": [ [ "species_10593834", "catalyst" ] ], "additional_components": [ "CHEBI:18075", "species_29420", "CHEBI:28850", "CHEBI:28862", "species_110096", "CHEBI:16174", "CHEBI:28846", "species_110094", "species_110614", "species_29438", "species_500739", "species_29892", "species_29494", "species_29604", "species_30185", "species_30187", "P34093", "DDB_G0279911" ] }, "reaction_10582668": { "compartment": "compartment_70101", "id": "reaction_10582668", "reactome": "R-DDI-110144", "name": "ADP + ADP <=> AMP + ATP [AK2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370" ], "products": [ "species_113592", "species_76577" ], "modifiers": [ [ "species_10582665", "catalyst" ] ], "additional_components": [ "DDB_G0283805" ] }, "reaction_10616659": { "compartment": "compartment_70101", "id": "reaction_10616659", "reactome": "R-DDI-6806877", "name": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6806885" ], "products": [ "species_29370", "species_6806881" ], "modifiers": [ [ "species_10616656", "catalyst" ] ], "additional_components": [ "P34093", "DDB_G0279911" ] }, "reaction_10580565": { "compartment": "compartment_70101", "id": "reaction_10580565", "reactome": "R-DDI-73647", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_29494", "species_29472" ], "products": [ "species_29372", "species_29404", "species_29370", "species_110614" ], "modifiers": [ [ "species_10580562", "catalyst" ] ], "additional_components": [ "Q54V77", "DDB_G0280567" ] }, "reaction_10580407": { "compartment": "compartment_70101", "id": "reaction_10580407", "reactome": "R-DDI-73548", "name": "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500009", "species_113592" ], "products": [ "species_29370", "species_500006" ], "modifiers": [ [ "species_10580404", "catalyst" ] ], "additional_components": [ "species_109395", "CHEBI:15918", "species_109402", "species_110096", "CHEBI:28846", "species_110094", "DDB_G0287495" ] }, "reaction_10593654": { "compartment": "compartment_70101", "id": "reaction_10593654", "reactome": "R-DDI-482619", "name": "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_482627" ], "products": [ "species_29370", "species_482625" ], "modifiers": [ [ "species_10593651", "catalyst" ] ], "additional_components": [ "species_110096", "CHEBI:28846", "CHEBI:16174", "species_29420", "CHEBI:28850", "CHEBI:28862", "CHEBI:18075", "species_110094", "species_29892", "species_29604", "species_30185", "species_29494", "species_30187", "species_110614", "species_500739", "species_29438", "P34093", "DDB_G0279911" ] }, "reaction_10612827": { "compartment": "compartment_5460", "id": "reaction_10612827", "reactome": "R-DDI-6788798", "name": "AK4 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_6788802" ], "products": [ "species_113581", "species_6788801" ], "modifiers": [ [ "species_10612824", "catalyst" ] ], "additional_components": [ "species_109395", "species_109386", "species_76577", "CHEBI:15918", "species_29370", "CHEBI:16174", "CHEBI:28846", "species_110094", "DDB_G0292730" ] }, "reaction_10593851": { "compartment": "compartment_70101", "id": "reaction_10593851", "reactome": "R-DDI-504054", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_29494", "species_29472" ], "products": [ "species_29372", "species_29404", "species_29370", "species_110614" ], "modifiers": [ [ "species_10593848", "catalyst" ] ], "additional_components": [ "Q54V77", "DDB_G0280567" ] }, "reaction_10580575": { "compartment": "compartment_7660", "id": "reaction_10580575", "reactome": "R-DDI-73666", "name": "dUTP + H2O => dUMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_500739" ], "products": [ "species_113541", "species_500742" ], "modifiers": [ [ "species_10580572", "catalyst" ] ], "additional_components": [ "Q54BW5", "DDB_G0293374" ] }, "reaction_10580545": { "compartment": "compartment_70101", "id": "reaction_10580545", "reactome": "R-DDI-73632", "name": "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_83928" ], "products": [ "species_29370", "species_109366" ], "modifiers": [ [ "species_10580542", "catalyst" ] ], "additional_components": [ "Q27564", "DDB_G0289179" ] }, "reaction_10580529": { "compartment": "compartment_70101", "id": "reaction_10580529", "reactome": "R-DDI-73608", "name": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500829" ], "products": [ "species_500430", "species_31633" ], "modifiers": [ [ "species_10580526", "catalyst" ] ], "additional_components": [ "CHEBI:15698", "CHEBI:17562", "CHEBI:16450", "CHEBI:16704", "species_29426", "Q54I82", "DDB_G0288933" ] }, "reaction_10623936": { "compartment": "compartment_70101", "id": "reaction_10623936", "reactome": "R-DDI-8954327", "name": "UCKL1 phosphorylates urindine, cytidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500759" ], "products": [ "species_500761", "species_29370" ], "modifiers": [ [ "species_10623933", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:17562", "species_109395", "species_109402", "DDB_G0274559" ] }, "reaction_10582628": { "compartment": "compartment_70101", "id": "reaction_10582628", "reactome": "R-DDI-109903", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500759" ], "products": [ "species_500761", "species_29370" ], "modifiers": [ [ "species_10582625", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:17562", "species_109395", "species_109402", "Q55EL3", "DDB_G0269034", "Q8T154", "DDB_G0274559" ] }, "reaction_10580519": { "compartment": "compartment_70101", "id": "reaction_10580519", "reactome": "R-DDI-73599", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500759" ], "products": [ "species_500761", "species_29370" ], "modifiers": [ [ "species_10580516", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:17562", "species_109395", "species_109402", "Q8T154", "DDB_G0274559", "Q55EL3", "DDB_G0269034" ] }, "reaction_10581238": { "compartment": "compartment_70101", "id": "reaction_10581238", "reactome": "R-DDI-74372", "name": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83962", "species_500244" ], "products": [ "species_29372", "species_500430" ], "modifiers": [ [ "species_10581235", "catalyst" ] ], "additional_components": [ "CHEBI:28542", "species_112016", "CHEBI:16450", "CHEBI:16704", "Q54PM8", "DDB_G0284431" ] }, "reaction_10580502": { "compartment": "compartment_70101", "id": "reaction_10580502", "reactome": "R-DDI-73598", "name": "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500829", "species_113592" ], "products": [ "species_500828", "species_29370" ], "modifiers": [ [ "species_10580499", "catalyst" ] ], "additional_components": [ "CHEBI:15698", "CHEBI:17562", "species_109395", "CHEBI:15918", "Q54YL2", "DDB_G0278191", "species_29926" ] }, "reaction_10582606": { "compartment": "compartment_5460", "id": "reaction_10582606", "reactome": "R-DDI-109759", "name": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_500822" ], "products": [ "species_113581", "species_500823" ], "modifiers": [ [ "species_10582603", "catalyst" ] ], "additional_components": [ "species_83928", "CHEBI:16450", "CHEBI:15698", "species_109366", "species_500742", "CHEBI:15918", "DDB_G0278191" ] }, "reaction_10582353": { "compartment": "compartment_70101", "id": "reaction_10582353", "reactome": "R-DDI-76590", "name": "AMP + H2O => IMP + NH4+ (AMPD)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_76577" ], "products": [ "species_29602", "species_31633" ], "modifiers": [ [ "species_10582350", "catalyst" ] ], "additional_components": [ "Q54DD0", "DDB_G0292266" ] }, "reaction_10581184": { "compartment": "compartment_5460", "id": "reaction_10581184", "reactome": "R-DDI-74207", "name": "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_500224" ], "products": [ "species_113581", "species_500222" ], "modifiers": [ [ "species_10581181", "catalyst" ] ], "additional_components": [ "CHEBI:17172", "CHEBI:17256", "CHEBI:28997", "CHEBI:16192", "species_109386", "species_109330", "Q54YL2", "DDB_G0278191" ] }, "reaction_10582544": { "compartment": "compartment_70101", "id": "reaction_10582544", "reactome": "R-DDI-109624", "name": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500173", "species_113592" ], "products": [ "species_500088", "species_29370" ], "modifiers": [ [ "species_10582541", "catalyst" ] ], "additional_components": [ "species_83909", "CHEBI:17256", "species_76577", "species_109386", "species_29926", "Q54MB5", "DDB_G0286057" ] }, "reaction_10581192": { "compartment": "compartment_70101", "id": "reaction_10581192", "reactome": "R-DDI-74241", "name": "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH4+ (ADA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500173" ], "products": [ "species_500172", "species_31633" ], "modifiers": [ [ "species_10581189", "catalyst" ] ], "additional_components": [ "species_83909", "CHEBI:17256", "CHEBI:28997", "species_83921", "DDB_G0287371" ] }, "reaction_10582554": { "compartment": "compartment_70101", "id": "reaction_10582554", "reactome": "R-DDI-109671", "name": "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500201", "species_113592" ], "products": [ "species_29370", "species_500199" ], "modifiers": [ [ "species_10580499", "catalyst" ] ], "additional_components": [ "CHEBI:17172", "CHEBI:17256", "species_109386", "CHEBI:16192", "Q54YL2", "DDB_G0278191", "species_29926" ] }, "reaction_10580768": { "compartment": "compartment_70101", "id": "reaction_10580768", "reactome": "R-DDI-73813", "name": "GAR + 10-Formyl-THF => FGAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111338", "species_419151" ], "products": [ "species_111354", "species_111355" ], "modifiers": [ [ "species_10580754", "catalyst" ] ], "additional_components": [ "DDB_G0290121" ] }, "reaction_10580771": { "compartment": "compartment_70101", "id": "reaction_10580771", "reactome": "R-DDI-73814", "name": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111292", "species_113592", "species_29424" ], "products": [ "species_29372", "species_111338", "species_29370" ], "modifiers": [ [ "species_10580754", "catalyst" ] ], "additional_components": [ "DDB_G0290121" ] }, "reaction_10580723": { "compartment": "compartment_70101", "id": "reaction_10580723", "reactome": "R-DDI-73792", "name": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_111584", "species_29472" ], "products": [ "species_111294", "species_29404", "species_113578", "species_76577" ], "modifiers": [ [ "species_10580720", "catalyst" ] ], "additional_components": [ "DDB_G0281551" ] }, "reaction_10580757": { "compartment": "compartment_70101", "id": "reaction_10580757", "reactome": "R-DDI-73810", "name": "FGAM + ATP => AIR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111369" ], "products": [ "species_29372", "species_111370", "species_29370" ], "modifiers": [ [ "species_10580754", "catalyst" ] ], "additional_components": [ "DDB_G0290121" ] }, "reaction_10582854": { "compartment": "compartment_70101", "id": "reaction_10582854", "reactome": "R-DDI-111524", "name": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29448", "species_29602" ], "products": [ "species_29372", "species_29420", "species_35141" ], "modifiers": [ [ "species_10582851", "catalyst" ], [ "species_113578", "inhibitor" ], [ "species_29420", "inhibitor" ], [ "species_30014", "inhibitor" ], [ "species_35141", "inhibitor" ] ], "additional_components": [ "species_29926", "P21900", "DDB_G0285429" ] }, "reaction_10627338": { "compartment": "compartment_70101", "id": "reaction_10627338", "reactome": "R-DDI-9678749", "name": "IMPDH tetramers binds IMPDH inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9678719", "species_10580730" ], "products": [ "species_10580733" ], "modifiers": [], "additional_components": [ "Q54QQ0", "DDB_G0283701", "Q54QQ0", "DDB_G0283701" ] }, "reaction_10580746": { "compartment": "compartment_70101", "id": "reaction_10580746", "reactome": "R-DDI-73797", "name": "FAICAR => IMP + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111427" ], "products": [ "species_29356", "species_29602" ], "modifiers": [ [ "species_10580743", "catalyst" ] ], "additional_components": [ "Q86L14", "DDB_G0277087" ] }, "reaction_10580765": { "compartment": "compartment_70101", "id": "reaction_10580765", "reactome": "R-DDI-73812", "name": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111354", "species_113592", "species_29472" ], "products": [ "species_29372", "species_29404", "species_29370", "species_111369" ], "modifiers": [ [ "species_10580762", "catalyst" ] ], "additional_components": [ "DDB_G0288145" ] }, "reaction_10580749": { "compartment": "compartment_70101", "id": "reaction_10580749", "reactome": "R-DDI-73798", "name": "AICAR + 10-Formyl-THF => FAICAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_419151", "species_111409" ], "products": [ "species_111355", "species_111427" ], "modifiers": [ [ "species_10580743", "catalyst" ] ], "additional_components": [ "Q86L14", "DDB_G0277087" ] }, "reaction_10580735": { "compartment": "compartment_70101", "id": "reaction_10580735", "reactome": "R-DDI-73794", "name": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29602", "species_29360" ], "products": [ "species_70106", "species_111584", "species_73473" ], "modifiers": [ [ "species_10580730", "catalyst" ], [ "species_111584", "inhibitor" ], [ "species_10580733", "inhibitor" ] ], "additional_components": [ "Q54QQ0", "DDB_G0283701", "Q54QQ0", "DDB_G0283701" ] }, "reaction_10580433": { "compartment": "compartment_70101", "id": "reaction_10580433", "reactome": "R-DDI-73573", "name": "CAD hexamer transforms CAP to N-carb-L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111647", "species_29448" ], "products": [ "species_111628", "species_29372" ], "modifiers": [ [ "species_10580427", "catalyst" ] ], "additional_components": [ "P20054", "DDB_G0276335" ] }, "reaction_10580417": { "compartment": "compartment_70101", "id": "reaction_10580417", "reactome": "R-DDI-73564", "name": "UMPS dimer decarboxylates OMP to UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111629" ], "products": [ "species_109402", "species_113528" ], "modifiers": [ [ "species_10580414", "catalyst" ] ], "additional_components": [ "P09556", "DDB_G0280041" ] }, "reaction_10580436": { "compartment": "compartment_70101", "id": "reaction_10580436", "reactome": "R-DDI-73577", "name": "CAD hexamer transforms L-Gln to CAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111627", "species_113592", "species_29472" ], "products": [ "species_111647", "species_29372", "species_29404", "species_29370" ], "modifiers": [ [ "species_10580427", "catalyst" ] ], "additional_components": [ "P20054", "DDB_G0276335" ] }, "reaction_10580420": { "compartment": "compartment_70101", "id": "reaction_10580420", "reactome": "R-DDI-73567", "name": "UMPS dimer transfers phoshoribosyl group to ORO to form OMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_76632" ], "products": [ "species_111294", "species_111629" ], "modifiers": [ [ "species_10580414", "catalyst" ] ], "additional_components": [ "P09556", "DDB_G0280041" ] }, "reaction_10580430": { "compartment": "compartment_70101", "id": "reaction_10580430", "reactome": "R-DDI-73571", "name": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111628", "species_70106" ], "products": [ "species_29356", "species_76630" ], "modifiers": [ [ "species_10580427", "catalyst" ] ], "additional_components": [ "P20054", "DDB_G0276335" ] }, "reaction_10611880": { "compartment": "compartment_12045", "id": "reaction_10611880", "reactome": "R-DDI-5696021", "name": "ADPGK:Mg2+ phosphorylates Glc to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_70113" ], "products": [ "species_30537", "species_76577" ], "modifiers": [ [ "species_10611877", "catalyst" ] ], "additional_components": [ "species_29926", "Q54K22", "DDB_G0287631" ] }, "reaction_10578788": { "compartment": "compartment_70101", "id": "reaction_10578788", "reactome": "R-DDI-71802", "name": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29512" ], "products": [ "species_29370", "species_30533" ], "modifiers": [ [ "species_10578785", "catalyst" ], [ "species_30533", "catalyst" ] ], "additional_components": [ "Q54SI2", "DDB_G0282759", "Q551Y6", "DDB_G0282759" ] }, "reaction_10577647": { "compartment": "compartment_70101", "id": "reaction_10577647", "reactome": "R-DDI-70262", "name": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30533" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10577644", "catalyst" ] ], "additional_components": [ "Q54SI2", "DDB_G0282759", "Q551Y6", "DDB_G0282759" ] }, "reaction_10578671": { "compartment": "compartment_70101", "id": "reaction_10578671", "reactome": "R-DDI-71670", "name": "phosphoenolpyruvate + ADP => pyruvate + ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29370", "species_29492" ], "products": [ "species_113592", "species_29398" ], "modifiers": [ [ "species_10578668", "catalyst" ], [ "species_30014", "catalyst" ], [ "species_76183", "inhibitor" ], [ "species_29358", "inhibitor" ], [ "species_30389", "inhibitor" ] ], "additional_components": [ "Q54RF5", "DDB_G0283247", "species_29926", "species_74126" ] }, "reaction_10613720": { "compartment": "compartment_70101", "id": "reaction_10613720", "reactome": "R-DDI-6798335", "name": "BPGM dimer isomerises 1,3BPG to 2,3BPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29800" ], "products": [ "species_6798337" ], "modifiers": [ [ "species_10613717", "catalyst" ] ], "additional_components": [ "Q54NE6", "DDB_G0285311" ] }, "reaction_10616029": { "compartment": "compartment_70101", "id": "reaction_10616029", "reactome": "R-DDI-6799604", "name": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_449701" ], "products": [ "species_29512", "species_31633" ], "modifiers": [ [ "species_10616026", "catalyst" ] ], "additional_components": [ "Q54XK9", "DDB_G0278873" ] }, "reaction_10623996": { "compartment": "compartment_70101", "id": "reaction_10623996", "reactome": "R-DDI-8955760", "name": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30537", "species_29800" ], "products": [ "species_70106", "species_8955759", "species_29728" ], "modifiers": [ [ "species_10577658", "catalyst" ] ], "additional_components": [ "species_29926", "Q54UQ2", "DDB_G0280897" ] }, "reaction_10606595": { "compartment": "compartment_70101", "id": "reaction_10606595", "reactome": "R-DDI-5661256", "name": "AKR1A1 reduces D-glucuronate to L-gulonate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_5661264", "species_29364" ], "products": [ "species_29366", "species_5661268" ], "modifiers": [ [ "species_10606592", "catalyst" ] ], "additional_components": [ "DDB_G0293850" ] }, "reaction_10626289": { "compartment": "compartment_161320", "id": "reaction_10626289", "reactome": "R-DDI-9638075", "name": "HEXB cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065269" ], "products": [ "species_1605658", "species_2105025" ], "modifiers": [ [ "species_10598378", "catalyst" ] ], "additional_components": [ "P13723", "DDB_G0287033" ] }, "reaction_10600151": { "compartment": "compartment_161320", "id": "reaction_10600151", "reactome": "R-DDI-2105001", "name": "HEXA cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065269" ], "products": [ "species_1605658", "species_2105025" ], "modifiers": [ [ "species_10598376", "catalyst" ] ], "additional_components": [ "Q54K55", "DDB_G0287597", "Q54SC9", "DDB_G0282539", "Q54K56", "DDB_G0287659", "Q54MU9", "DDB_G0285647", "P13723", "DDB_G0287033" ] }, "reaction_10599228": { "compartment": "compartment_161320", "id": "reaction_10599228", "reactome": "R-DDI-1793186", "name": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2105025" ], "products": [ "species_2104993", "species_1678617" ], "modifiers": [ [ "species_10599145", "catalyst" ] ], "additional_components": [ "DDB_G0288289" ] }, "reaction_10594113": { "compartment": "compartment_20699", "id": "reaction_10594113", "reactome": "R-DDI-741449", "name": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471" ], "products": [ "species_741440" ], "modifiers": [ [ "species_10594110", "catalyst" ] ], "additional_components": [ "DDB_G0269602" ] }, "reaction_10591509": { "compartment": "compartment_876", "id": "reaction_10591509", "reactome": "R-DDI-427555", "name": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_427648" ], "products": [ "species_70106", "species_174375" ], "modifiers": [ [ "species_10591506", "catalyst" ] ], "additional_components": [ "B0G157", "DDB_G0286611", "Q55FK8", "DDB_G0286611" ] }, "reaction_10598500": { "compartment": "compartment_161320", "id": "reaction_10598500", "reactome": "R-DDI-1630306", "name": "GLB1 hydrolyses a glycosaminoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2104997" ], "products": [ "species_1605637", "species_2104995" ], "modifiers": [ [ "species_10598338", "catalyst" ] ], "additional_components": [ "DDB_G0290217" ] }, "reaction_10598503": { "compartment": "compartment_161320", "id": "reaction_10598503", "reactome": "R-DDI-1638053", "name": "HEXA cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2105012" ], "products": [ "species_2105010", "species_1605658" ], "modifiers": [ [ "species_10598376", "catalyst" ] ], "additional_components": [ "Q54K55", "DDB_G0287597", "Q54SC9", "DDB_G0282539", "Q54K56", "DDB_G0287659", "Q54MU9", "DDB_G0285647", "P13723", "DDB_G0287033" ] }, "reaction_10626293": { "compartment": "compartment_161320", "id": "reaction_10626293", "reactome": "R-DDI-9638078", "name": "HEXB cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2105012" ], "products": [ "species_2105010", "species_1605658" ], "modifiers": [ [ "species_10598378", "catalyst" ] ], "additional_components": [ "P13723", "DDB_G0287033" ] }, "reaction_10626002": { "compartment": "compartment_17963", "id": "reaction_10626002", "reactome": "R-DDI-9603984", "name": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9033790", "species_205683" ], "products": [ "species_9605593", "species_205689" ], "modifiers": [ [ "species_10625999", "catalyst" ] ], "additional_components": [ "Q54PK0", "DDB_G0284775", "Q54PJ9", "DDB_G0284775", "Q54RA6", "DDB_G0284775", "Q54PK3", "DDB_G0284551", "Q86J24", "DDB_G0284775", "Q54PH9", "DDB_G0284467", "Q54P60", "DDB_G0284775" ] }, "reaction_10626007": { "compartment": "compartment_17963", "id": "reaction_10626007", "reactome": "R-DDI-9605609", "name": "FUT3 transfers Fuc to Type 1 MSGG to form sLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605595", "species_205683" ], "products": [ "species_9605615", "species_205689" ], "modifiers": [ [ "species_10611506", "catalyst" ] ], "additional_components": [ "Q54PK0", "DDB_G0284775", "Q86J24", "DDB_G0284775", "Q54P60", "DDB_G0284775", "Q54PH9", "DDB_G0284467", "Q54PK3", "DDB_G0284551", "Q54RA6", "DDB_G0284775", "Q54PJ9", "DDB_G0284775" ] }, "reaction_10626004": { "compartment": "compartment_17963", "id": "reaction_10626004", "reactome": "R-DDI-9603986", "name": "FUT3 transfers Fuc to Type 1 chains to form LeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9036984", "species_205683" ], "products": [ "species_205689", "species_9605607" ], "modifiers": [ [ "species_10611506", "catalyst" ] ], "additional_components": [ "Q54PK0", "DDB_G0284775", "Q86J24", "DDB_G0284775", "Q54P60", "DDB_G0284775", "Q54PH9", "DDB_G0284467", "Q54PK3", "DDB_G0284551", "Q54RA6", "DDB_G0284775", "Q54PJ9", "DDB_G0284775" ] }, "reaction_10626009": { "compartment": "compartment_17963", "id": "reaction_10626009", "reactome": "R-DDI-9605644", "name": "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605649", "species_205683" ], "products": [ "species_205689", "species_9605651" ], "modifiers": [ [ "species_10611506", "catalyst" ] ], "additional_components": [ "Q54PK0", "DDB_G0284775", "Q86J24", "DDB_G0284775", "Q54P60", "DDB_G0284775", "Q54PH9", "DDB_G0284467", "Q54PK3", "DDB_G0284551", "Q54RA6", "DDB_G0284775", "Q54PJ9", "DDB_G0284775" ] }, "reaction_10626030": { "compartment": "compartment_17963", "id": "reaction_10626030", "reactome": "R-DDI-9605682", "name": "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9605685", "species_205683" ], "products": [ "species_9605661", "species_205689" ], "modifiers": [ [ "species_10626027", "catalyst" ] ], "additional_components": [ "Q54PK0", "DDB_G0284775", "Q86J24", "DDB_G0284775", "Q54P60", "DDB_G0284775", "Q54PH9", "DDB_G0284467", "Q54PK3", "DDB_G0284551", "Q54RA6", "DDB_G0284775", "Q54PJ9", "DDB_G0284775" ] }, "reaction_10606317": { "compartment": "compartment_17963", "id": "reaction_10606317", "reactome": "R-DDI-5653873", "name": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_964746" ], "modifiers": [ [ "species_10606314", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10577719": { "compartment": "compartment_70101", "id": "reaction_10577719", "reactome": "R-DDI-70427", "name": "PGM:Mg2+ isomerise G1P to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29548" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10577660", "catalyst" ] ], "additional_components": [ "Q54UQ2", "DDB_G0280897", "species_29926" ] }, "reaction_10615984": { "compartment": "compartment_70101", "id": "reaction_10615984", "reactome": "R-DDI-6799545", "name": "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6799540" ], "products": [ "species_429579", "species_6799543" ], "modifiers": [ [ "species_10615981", "catalyst" ] ], "additional_components": [ "species_29426", "Q54K67", "DDB_G0287577" ] }, "reaction_10619249": { "compartment": "compartment_161320", "id": "reaction_10619249", "reactome": "R-DDI-8853710", "name": "MANBA hydrolyses GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8853719" ], "products": [ "species_1678743", "species_6799594" ], "modifiers": [ [ "species_10619246", "catalyst" ] ], "additional_components": [ "DDB_G0275917" ] }, "reaction_10616013": { "compartment": "compartment_161320", "id": "reaction_10616013", "reactome": "R-DDI-6799581", "name": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6799577", "species_1605715" ], "products": [ "species_6799594", "species_8853719" ], "modifiers": [ [ "species_10616010", "catalyst" ] ], "additional_components": [ "Q54YF7", "DDB_G0278259", "P34098", "DDB_G0292206", "Q1ZXI8", "DDB_G0278651", "Q55ER0", "DDB_G0268994", "Q54YC4", "DDB_G0278653", "species_29426" ] }, "reaction_10619244": { "compartment": "compartment_161320", "id": "reaction_10619244", "reactome": "R-DDI-8853686", "name": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_8853396" ], "products": [ "species_6799577", "species_6799594" ], "modifiers": [ [ "species_10619241", "catalyst" ] ], "additional_components": [ "P34098", "DDB_G0292206", "species_29426" ] }, "reaction_10593362": { "compartment": "compartment_70101", "id": "reaction_10593362", "reactome": "R-DDI-453339", "name": "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_10578646" ], "products": [ "species_29548", "species_10593360" ], "modifiers": [ [ "species_10578628", "catalyst" ] ], "additional_components": [ "Q54L24", "DDB_G0286945", "species_266099", "species_266099", "Q54L24", "DDB_G0286945", "Q00766", "DDB_G0281383" ] }, "reaction_10593364": { "compartment": "compartment_70101", "id": "reaction_10593364", "reactome": "R-DDI-453342", "name": "PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10578574", "species_76577" ], "products": [ "species_10593354" ], "modifiers": [ [ "species_113592", "inhibitor" ], [ "species_30537", "inhibitor" ] ], "additional_components": [ "P34114", "DDB_G0291123", "Q00766", "DDB_G0281383", "species_76577", "P34114", "DDB_G0291123", "Q00766", "DDB_G0281383" ] }, "reaction_10625828": { "compartment": "compartment_161320", "id": "reaction_10625828", "reactome": "R-DDI-9036727", "name": "GAA hydrolyzes lysosomal glycogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_10625815" ], "products": [ "species_1605745", "species_10625819" ], "modifiers": [ [ "species_10625825", "catalyst" ] ], "additional_components": [ "species_266099", "Q54L24", "DDB_G0286945", "species_266099", "Q54L24", "DDB_G0286945", "Q55D50", "DDB_G0269790" ] }, "reaction_10578619": { "compartment": "compartment_70101", "id": "reaction_10578619", "reactome": "R-DDI-71552", "name": "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10578599" ], "products": [ "species_10578611" ], "modifiers": [ [ "species_10578616", "catalyst" ] ], "additional_components": [ "species_266099", "Q54L24", "DDB_G0286945", "species_266099", "Q54L24", "DDB_G0286945", "DDB_G0287569" ] }, "reaction_10578651": { "compartment": "compartment_70101", "id": "reaction_10578651", "reactome": "R-DDI-71593", "name": "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10578611" ], "products": [ "species_10578648", "species_70113" ], "modifiers": [ [ "species_10578616", "catalyst" ] ], "additional_components": [ "species_266099", "Q54L24", "DDB_G0286945", "species_266099", "Q54L24", "DDB_G0286945", "DDB_G0287569" ] }, "reaction_10578636": { "compartment": "compartment_70101", "id": "reaction_10578636", "reactome": "R-DDI-71590", "name": "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_10578633" ], "products": [ "species_29548", "species_10578597" ], "modifiers": [ [ "species_10578628", "catalyst" ] ], "additional_components": [ "Q54L24", "DDB_G0286945", "species_266099", "Q54L24", "DDB_G0286945", "species_266099", "Q00766", "DDB_G0281383" ] }, "reaction_10602624": { "compartment": "compartment_70101", "id": "reaction_10602624", "reactome": "R-DDI-3322041", "name": "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602568", "species_29410" ], "products": [ "species_10602621", "species_110096" ], "modifiers": [ [ "species_10602568", "catalyst" ], [ "species_30537", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945" ] }, "reaction_10602596": { "compartment": "compartment_70101", "id": "reaction_10602596", "reactome": "R-DDI-3322009", "name": "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602591", "species_29410" ], "products": [ "species_110096", "species_10602593" ], "modifiers": [ [ "species_10602591", "catalyst" ] ], "additional_components": [ "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945" ] }, "reaction_10602628": { "compartment": "compartment_70101", "id": "reaction_10602628", "reactome": "R-DDI-3322057", "name": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602621" ], "products": [ "species_10602626" ], "modifiers": [ [ "species_10602581", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945", "DDB_G0274105" ] }, "reaction_10577673": { "compartment": "compartment_70101", "id": "reaction_10577673", "reactome": "R-DDI-70286", "name": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29548", "species_29494" ], "products": [ "species_111294", "species_29410" ], "modifiers": [ [ "species_10577670", "catalyst" ] ], "additional_components": [ "Q54YZ0", "DDB_G0277879" ] }, "reaction_10602601": { "compartment": "compartment_70101", "id": "reaction_10602601", "reactome": "R-DDI-3322014", "name": "Autoglucosylation of GYG2 complexed with GYS2-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602598", "species_29410" ], "products": [ "species_10602591", "species_110096" ], "modifiers": [ [ "species_10602598", "catalyst" ] ], "additional_components": [ "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945" ] }, "reaction_10602571": { "compartment": "compartment_70101", "id": "reaction_10602571", "reactome": "R-DDI-3322003", "name": "Autoglucosylation of GYG1 complexed with GYS1-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602566", "species_29410" ], "products": [ "species_10602568", "species_110096" ], "modifiers": [ [ "species_10602566", "catalyst" ] ], "additional_components": [ "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "species_29926", "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945", "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "species_29926" ] }, "reaction_10602605": { "compartment": "compartment_70101", "id": "reaction_10602605", "reactome": "R-DDI-3322016", "name": "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602593" ], "products": [ "species_10602603" ], "modifiers": [ [ "species_10602581", "catalyst" ] ], "additional_components": [ "Q54L24", "DDB_G0286945", "species_29926", "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "DDB_G0274105" ] }, "reaction_10602614": { "compartment": "compartment_70101", "id": "reaction_10602614", "reactome": "R-DDI-3322019", "name": "Autoglucosylation of GYG2 complexed with GYS2-b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29410", "species_10602609" ], "products": [ "species_10602611", "species_110096" ], "modifiers": [ [ "species_10602609", "catalyst" ] ], "additional_components": [ "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945", "species_29926", "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "species_29926", "Q55GH4", "DDB_G0267674", "Q54L24", "DDB_G0286945" ] }, "reaction_10602584": { "compartment": "compartment_70101", "id": "reaction_10602584", "reactome": "R-DDI-3322005", "name": "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602556" ], "products": [ "species_10602576" ], "modifiers": [ [ "species_10602581", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945", "DDB_G0274105" ] }, "reaction_10602619": { "compartment": "compartment_70101", "id": "reaction_10602619", "reactome": "R-DDI-3322025", "name": "Autoglucosylation of GYG1 complexed with GYS1-a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602616", "species_29410" ], "products": [ "species_10602554", "species_110096" ], "modifiers": [ [ "species_10602616", "catalyst" ] ], "additional_components": [ "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "species_29926", "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945", "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "species_29926" ] }, "reaction_10626302": { "compartment": "compartment_70101", "id": "reaction_10626302", "reactome": "R-DDI-9638127", "name": "PGM1:Mg2+ isomerises G6P to G1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30537" ], "products": [ "species_29548" ], "modifiers": [ [ "species_10626297", "catalyst" ] ], "additional_components": [ "Q23919", "DDB_G0288483", "species_29926" ] }, "reaction_10602559": { "compartment": "compartment_70101", "id": "reaction_10602559", "reactome": "R-DDI-3322001", "name": "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602554", "species_29410" ], "products": [ "species_10602556", "species_110096" ], "modifiers": [ [ "species_10602554", "catalyst" ] ], "additional_components": [ "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945", "Q55GH4", "DDB_G0267674", "species_29926", "Q54L24", "DDB_G0286945" ] }, "reaction_10624322": { "compartment": "compartment_70101", "id": "reaction_10624322", "reactome": "R-DDI-8982667", "name": "PGM2:Mg2+ isomerises dR1P to dR5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787326" ], "products": [ "species_6787328" ], "modifiers": [ [ "species_10577654", "catalyst" ] ], "additional_components": [ "Q54UQ2", "DDB_G0280897", "species_29926" ] }, "reaction_10578464": { "compartment": "compartment_70101", "id": "reaction_10578464", "reactome": "R-DDI-71299", "name": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29996", "species_29366" ], "products": [ "species_70106", "species_113528", "species_29364", "species_29732" ], "modifiers": [ [ "species_10578461", "catalyst" ] ], "additional_components": [ "Q8TA03", "DDB_G0277885" ] }, "reaction_10624007": { "compartment": "compartment_70101", "id": "reaction_10624007", "reactome": "R-DDI-8955844", "name": "RBKS phosphorylates ribose to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8955853" ], "products": [ "species_73578", "species_29370" ], "modifiers": [ [ "species_10624004", "catalyst" ] ], "additional_components": [ "DDB_G0280893" ] }, "reaction_10578502": { "compartment": "compartment_70101", "id": "reaction_10578502", "reactome": "R-DDI-71334", "name": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29578", "species_29882" ], "products": [ "species_29512", "species_29878" ], "modifiers": [ [ "species_10578499", "catalyst" ] ], "additional_components": [ "Q54UP4", "DDB_G0280909" ] }, "reaction_10587241": { "compartment": "compartment_70101", "id": "reaction_10587241", "reactome": "R-DDI-199803", "name": "xylulose 5-phosphate <=> D-ribulose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29790" ], "products": [ "species_29732" ], "modifiers": [ [ "species_10578481", "catalyst" ] ], "additional_components": [ "Q54YE7", "DDB_G0278275", "species_71067" ] }, "reaction_10582811": { "compartment": "compartment_70101", "id": "reaction_10582811", "reactome": "R-DDI-111215", "name": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73578", "species_110644" ], "products": [ "species_73566", "species_109386" ], "modifiers": [ [ "species_10580455", "catalyst" ], [ "species_29926", "catalyst" ], [ "species_29372", "catalyst" ] ], "additional_components": [ "Q75JN8", "DDB_G0272246", "Q54PA9", "DDB_G0284669", "Q54QU9", "DDB_G0283627" ] }, "reaction_10580462": { "compartment": "compartment_70101", "id": "reaction_10580462", "reactome": "R-DDI-73580", "name": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73578", "species_113592" ], "products": [ "species_73566", "species_76577" ], "modifiers": [ [ "species_10580459", "catalyst" ] ], "additional_components": [ "Q75JN8", "DDB_G0272246", "Q54PA9", "DDB_G0284669", "Q54QU9", "DDB_G0283627" ] }, "reaction_10585872": { "compartment": "compartment_70101", "id": "reaction_10585872", "reactome": "R-DDI-177784", "name": "ribose 5-phosphate <=> D-ribulose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73578" ], "products": [ "species_29732" ], "modifiers": [ [ "species_10578489", "catalyst" ] ], "additional_components": [ "DDB_G0276711" ] }, "reaction_10612693": { "compartment": "compartment_70101", "id": "reaction_10612693", "reactome": "R-DDI-6787329", "name": "PGM2:Mg2+ isomerises R1P to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_112016" ], "products": [ "species_73578" ], "modifiers": [ [ "species_10577654", "catalyst" ] ], "additional_components": [ "Q54UQ2", "DDB_G0280897", "species_29926" ] }, "reaction_10578484": { "compartment": "compartment_70101", "id": "reaction_10578484", "reactome": "R-DDI-71303", "name": "RPE dimers isomerise RU5P to XY5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29732" ], "products": [ "species_29790" ], "modifiers": [ [ "species_10578481", "catalyst" ] ], "additional_components": [ "Q54YE7", "DDB_G0278275", "species_71067" ] }, "reaction_10578454": { "compartment": "compartment_70101", "id": "reaction_10578454", "reactome": "R-DDI-71296", "name": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_31467" ], "products": [ "species_29996" ], "modifiers": [ [ "species_10578451", "catalyst" ] ], "additional_components": [ "DDB_G0292898" ] }, "reaction_10587707": { "compartment": "compartment_70101", "id": "reaction_10587707", "reactome": "R-DDI-203553", "name": "eNOS binds NOSIP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587546", "species_10587703" ], "products": [ "species_10587705" ], "modifiers": [], "additional_components": [ "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "DDB_G0270882", "Q55DU4", "DDB_G0270882", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596" ] }, "reaction_10587771": { "compartment": "compartment_876", "id": "reaction_10587771", "reactome": "R-DDI-203680", "name": "eNOS:NOSIP translocation from caveolae to intracellular compartments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587705" ], "products": [ "species_10587769" ], "modifiers": [], "additional_components": [ "Q55DU4", "DDB_G0270882", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_917877", "species_29426", "species_76629", "Q55CT1", "DDB_G0269912", "species_113596", "species_29870", "Q55DU4", "DDB_G0270882" ] }, "reaction_10578208": { "compartment": "compartment_5460", "id": "reaction_10578208", "reactome": "R-DDI-70982", "name": "Fumarate + H2O <=> (S)-Malate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113588", "species_113521" ], "products": [ "species_113544" ], "modifiers": [ [ "species_10578205", "catalyst" ] ], "additional_components": [ "Q54VA2", "DDB_G0280495" ] }, "reaction_10578755": { "compartment": "compartment_5460", "id": "reaction_10578755", "reactome": "R-DDI-71775", "name": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70958", "species_113548", "species_113525" ], "products": [ "species_29374", "species_113573", "species_113536" ], "modifiers": [ [ "species_10578752", "catalyst" ] ], "additional_components": [ "P36967", "DDB_G0289325", "Q869S7", "DDB_G0274449" ] }, "reaction_10578180": { "compartment": "compartment_5460", "id": "reaction_10578180", "reactome": "R-DDI-70967", "name": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_29938" ], "products": [ "species_113594", "species_113529", "species_29362", "species_29376" ], "modifiers": [ [ "species_10578177", "catalyst" ], [ "species_113581", "catalyst" ] ], "additional_components": [ "species_266099", "Q55BI2", "DDB_G0271344", "Q54B68", "DDB_G0293872" ] }, "reaction_10593319": { "compartment": "compartment_5462", "id": "reaction_10593319", "reactome": "R-DDI-450971", "name": "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_113526", "species_113600" ], "products": [ "species_113563", "species_113529", "species_29362" ], "modifiers": [ [ "species_10593316", "catalyst" ] ], "additional_components": [ "Q55F30", "DDB_G0269046" ] }, "reaction_10624580": { "compartment": "compartment_5460", "id": "reaction_10624580", "reactome": "R-DDI-9012016", "name": "FAHD1:Zn2+ dimer hydrolyses OA to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113587" ], "products": [ "species_113557", "species_29376" ], "modifiers": [ [ "species_10624577", "catalyst" ] ], "additional_components": [ "species_29926", "Q86I22", "DDB_G0275071" ] }, "reaction_10593321": { "compartment": "compartment_5460", "id": "reaction_10593321", "reactome": "R-DDI-450975", "name": "isocitrate <=> citrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29938" ], "products": [ "species_29654" ], "modifiers": [ [ "species_10578185", "catalyst" ] ], "additional_components": [ "DDB_G0278779" ] }, "reaction_10578537": { "compartment": "compartment_5460", "id": "reaction_10578537", "reactome": "R-DDI-71401", "name": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113594", "species_113526" ], "products": [ "species_70958", "species_29362", "species_29376" ], "modifiers": [ [ "species_10578297", "catalyst" ] ], "additional_components": [ "CHEBI:17460", "Q869Y7", "DDB_G0275029", "Q54JE4", "DDB_G0288127", "species_8878387", "Q54EW8", "DDB_G0291648", "species_113596" ] }, "reaction_10578252": { "compartment": "compartment_5460", "id": "reaction_10578252", "reactome": "R-DDI-70997", "name": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70958", "species_113548", "species_113581" ], "products": [ "species_29374", "species_113593", "species_113536" ], "modifiers": [ [ "species_10578249", "catalyst" ] ], "additional_components": [ "P36967", "DDB_G0289325", "Q55AI5", "DDB_G0271842" ] }, "reaction_10578198": { "compartment": "compartment_5460", "id": "reaction_10578198", "reactome": "R-DDI-70975", "name": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559", "species_113587", "species_113521" ], "products": [ "species_29374", "species_29654" ], "modifiers": [ [ "species_10578195", "catalyst" ] ], "additional_components": [ "Q553V1", "DDB_G0275311" ] }, "reaction_10624629": { "compartment": "compartment_5460", "id": "reaction_10624629", "reactome": "R-DDI-9012349", "name": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_113544" ], "products": [ "species_113529", "species_113557", "species_113600", "species_29376" ], "modifiers": [ [ "species_10624626", "catalyst" ] ], "additional_components": [ "species_29926", "Q6TU48", "DDB_G0272524" ] }, "reaction_10578237": { "compartment": "compartment_5460", "id": "reaction_10578237", "reactome": "R-DDI-70994", "name": "Succinate <=> Fumarate (with FAD redox reaction on enzyme)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113536" ], "products": [ "species_113588" ], "modifiers": [ [ "species_10578234", "catalyst" ] ], "additional_components": [ "Q8T2T5", "DDB_G0275115", "Q9U3X4", "DDB_G0280535", "species_113596", "Q54YN1", "DDB_G0278157", "Q55CC2", "DDB_G0270120" ] }, "reaction_10624605": { "compartment": "compartment_5460", "id": "reaction_10624605", "reactome": "R-DDI-9012268", "name": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113544", "species_113526" ], "products": [ "species_113529", "species_113557", "species_29362", "species_29376" ], "modifiers": [ [ "species_10624602", "catalyst" ], [ "species_113588", "catalyst" ], [ "species_113593", "inhibitor" ] ], "additional_components": [ "Q6TU48", "DDB_G0272524", "species_29926" ] }, "reaction_10624594": { "compartment": "compartment_70101", "id": "reaction_10624594", "reactome": "R-DDI-9012036", "name": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_198498" ], "products": [ "species_70106", "species_113528", "species_29398", "species_29364" ], "modifiers": [ [ "species_10624591", "catalyst" ] ], "additional_components": [ "species_29926", "Q6TU48", "DDB_G0272524" ] }, "reaction_10612481": { "compartment": "compartment_70101", "id": "reaction_10612481", "reactome": "R-DDI-6783221", "name": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694130" ], "products": [ "species_29708", "species_29450" ], "modifiers": [ [ "species_10612478", "catalyst" ] ], "additional_components": [ "species_29426", "Q54MR1", "DDB_G0285717" ] }, "reaction_10578535": { "compartment": "compartment_5460", "id": "reaction_10578535", "reactome": "R-DDI-71397", "name": "lipo-PDH decarboxylates PYR to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_113557" ], "products": [ "species_113559", "species_29362", "species_29376" ], "modifiers": [ [ "species_10578532", "catalyst" ] ], "additional_components": [ "Q86AD5", "DDB_G0271564", "Q54C70", "DDB_G0292994", "Q86HX0", "DDB_G0276417", "species_8878387", "P36413", "DDB_G0277847", "Q54EW8", "DDB_G0291648", "species_113596" ] }, "reaction_10624632": { "compartment": "compartment_70101", "id": "reaction_10624632", "reactome": "R-DDI-9012374", "name": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398" ], "products": [ "species_9012375" ], "modifiers": [ [ "species_10604611", "catalyst" ] ], "additional_components": [ "DDB_G0271848" ] }, "reaction_10594272": { "compartment": "compartment_70616", "id": "reaction_10594272", "reactome": "R-DDI-880050", "name": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_880013" ], "products": [ "species_113594", "species_31649" ], "modifiers": [ [ "species_10594269", "catalyst" ] ], "additional_components": [ "DDB_G0267656" ] }, "reaction_10594262": { "compartment": "compartment_5460", "id": "reaction_10594262", "reactome": "R-DDI-880007", "name": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_879997" ], "products": [ "species_113594", "species_31649" ], "modifiers": [ [ "species_10594259", "catalyst" ], [ "species_880069", "catalyst" ], [ "species_880067", "catalyst" ], [ "species_113527", "catalyst" ] ], "additional_components": [ "DDB_G0270500" ] }, "reaction_10594264": { "compartment": "compartment_5460", "id": "reaction_10594264", "reactome": "R-DDI-880033", "name": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_880041" ], "products": [ "species_880046", "species_879997" ], "modifiers": [ [ "species_10594251", "catalyst" ] ], "additional_components": [ "DDB_G0290111" ] }, "reaction_10597540": { "compartment": "compartment_5460", "id": "reaction_10597540", "reactome": "R-DDI-1362416", "name": "Frataxin binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113531", "species_10597538" ], "products": [ "species_10597511" ], "modifiers": [], "additional_components": [ "Q54C45", "DDB_G0293246", "Q54X04", "DDB_G0279287", "Q54RP2", "DDB_G0283003", "Q54FN9", "DDB_G0290725", "Q54C45", "DDB_G0293246", "species_71067", "Q54X04", "DDB_G0279287", "Q54RP2", "DDB_G0283003", "Q54FN9", "DDB_G0290725" ] }, "reaction_10600913": { "compartment": "compartment_5460", "id": "reaction_10600913", "reactome": "R-DDI-2395512", "name": "FDXR transfers electrons to FDX1,2 (FDX1L)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597532", "species_10600909" ], "products": [ "species_10600911", "species_113529", "species_10597524" ], "modifiers": [], "additional_components": [ "CHEBI:33737", "Q55GW1", "DDB_G0267486", "species_31649", "Q54KG7", "DDB_G0287353", "Q54KG7", "DDB_G0287353", "species_113596", "Q55GW1", "DDB_G0267486", "CHEBI:33738" ] }, "reaction_10600915": { "compartment": "compartment_5460", "id": "reaction_10600915", "reactome": "R-DDI-2395517", "name": "NADPH transfers electrons to FDXR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600911", "species_113529", "species_113600" ], "products": [ "species_10600909", "species_113563" ], "modifiers": [], "additional_components": [ "Q54KG7", "DDB_G0287353", "species_113596", "species_31649", "Q54KG7", "DDB_G0287353" ] }, "reaction_10622794": { "compartment": "compartment_5460", "id": "reaction_10622794", "reactome": "R-DDI-8878815", "name": "Formation of 4Fe-4S cluster on ISCA1:ISCA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622773", "species_10622785" ], "products": [ "species_10622771", "species_10622787" ], "modifiers": [ [ "species_10622792", "catalyst" ] ], "additional_components": [ "Q555C8", "DDB_G0274657", "CHEBI:33739", "Q54VS1", "DDB_G0280173", "Q54P40", "DDB_G0284809", "DDB_G0274657", "Q54VS1", "DDB_G0280173", "Q54P40", "DDB_G0284809", "CHEBI:49883", "DDB_G0280889" ] }, "reaction_10597535": { "compartment": "compartment_5460", "id": "reaction_10597535", "reactome": "R-DDI-1362408", "name": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_379721", "species_10597511", "species_10597524" ], "products": [ "species_10597532", "species_10597526", "species_379697" ], "modifiers": [ [ "species_10597511", "catalyst" ], [ "species_10597524", "catalyst" ] ], "additional_components": [ "Q54C45", "DDB_G0293246", "species_71067", "Q54X04", "DDB_G0279287", "Q54RP2", "DDB_G0283003", "Q54FN9", "DDB_G0290725", "Q55GW1", "DDB_G0267486", "CHEBI:33738", "CHEBI:33737", "Q55GW1", "DDB_G0267486", "Q54C45", "DDB_G0293246", "Q54X04", "DDB_G0279287", "Q54RP2", "DDB_G0283003", "CHEBI:33739", "Q54FN9", "DDB_G0290725", "Q54C45", "DDB_G0293246", "species_71067", "Q54X04", "DDB_G0279287", "Q54RP2", "DDB_G0283003", "Q54FN9", "DDB_G0290725", "Q55GW1", "DDB_G0267486", "CHEBI:33738" ] }, "reaction_10584066": { "compartment": "compartment_7660", "id": "reaction_10584066", "reactome": "R-DDI-163664", "name": "AMP binds to gamma subunit of AMP kinase heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584060", "species_164121" ], "products": [ "species_10584064" ], "modifiers": [], "additional_components": [ "Q54YF2", "DDB_G0277905", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "species_76577" ] }, "reaction_10593844": { "compartment": "compartment_876", "id": "reaction_10593844", "reactome": "R-DDI-499981", "name": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10593841", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10590676": { "compartment": "compartment_876", "id": "reaction_10590676", "reactome": "R-DDI-399998", "name": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10590673", "catalyst" ] ], "additional_components": [ "species_29438" ] }, "reaction_10592344": { "compartment": "compartment_876", "id": "reaction_10592344", "reactome": "R-DDI-434381", "name": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_400452" ], "products": [ "species_3632881" ], "modifiers": [ [ "species_10592341", "catalyst" ] ], "additional_components": [ "Q9XYS8", "DDB_G0267406", "Q55FQ9", "DDB_G0267440", "Q9BKJ9", "DDB_G0287035" ] }, "reaction_10613507": { "compartment": "compartment_5460", "id": "reaction_10613507", "reactome": "R-DDI-6792572", "name": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611515", "species_10613491" ], "products": [ "species_10611517", "species_10613499" ], "modifiers": [ [ "species_10613504", "catalyst" ] ], "additional_components": [ "DDB_G0287773", "Q54VG0", "DDB_G0280353", "P36413", "DDB_G0277847", "Q86AD5", "DDB_G0271564", "Q54C70", "DDB_G0292994", "Q86HX0", "DDB_G0276417", "species_8878387", "Q54EW8", "DDB_G0291648", "species_113596", "CHEBI:17460", "Q869Y7", "DDB_G0275029", "Q54JE4", "DDB_G0288127", "Q55FN7", "DDB_G0268020", "Q54M22", "DDB_G0286335", "Q54TR7", "DDB_G0281797", "DDB_G0287773", "Q86AD5", "DDB_G0271564", "Q54C70", "DDB_G0292994", "Q86HX0", "DDB_G0276417", "species_8878387", "P36413", "DDB_G0277847", "Q54EW8", "DDB_G0291648", "species_113596", "Q54TR7", "DDB_G0281797", "Q55FN7", "DDB_G0268020", "Q54M22", "DDB_G0286335", "CHEBI:17460", "Q869Y7", "DDB_G0275029", "Q54JE4", "DDB_G0288127", "Q54VG0", "DDB_G0280353", "DDB_G0287107" ] }, "reaction_10590402": { "compartment": "compartment_17951", "id": "reaction_10590402", "reactome": "R-DDI-389821", "name": "glycine + O2 => glyoxylate + H2O2 + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_193446" ], "products": [ "species_389678", "species_389843", "species_113575" ], "modifiers": [ [ "species_10590399", "catalyst" ] ], "additional_components": [ "species_113596", "Q556W1", "DDB_G0273291" ] }, "reaction_10613525": { "compartment": "compartment_5460", "id": "reaction_10613525", "reactome": "R-DDI-6793590", "name": "LIPT2 transfers octanoyl group to GCSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611517", "species_10613514" ], "products": [ "species_10613517", "species_10613512" ], "modifiers": [ [ "species_10613522", "catalyst" ] ], "additional_components": [ "DDB_G0287773", "CHEBI:25650", "Q54E22", "DDB_G0291866", "DDB_G0287773", "DDB_G0291866", "DDB_G0275417" ] }, "reaction_10590342": { "compartment": "compartment_17951", "id": "reaction_10590342", "reactome": "R-DDI-389684", "name": "glyoxylate + alanine => glycine + pyruvate [peroxisome]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389678", "species_389664" ], "products": [ "species_389680", "species_193446" ], "modifiers": [ [ "species_10590339", "catalyst" ] ], "additional_components": [ "Q54GT6", "DDB_G0289923" ] }, "reaction_10590422": { "compartment": "compartment_17951", "id": "reaction_10590422", "reactome": "R-DDI-389842", "name": "HAO1 tetramer oxidizes glycolate to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389822" ], "products": [ "species_389678", "species_113575" ], "modifiers": [ [ "species_10590419", "catalyst" ] ], "additional_components": [ "species_76629", "Q54E41", "DDB_G0291814" ] }, "reaction_10590425": { "compartment": "compartment_17951", "id": "reaction_10590425", "reactome": "R-DDI-389862", "name": "Conversion of glyoxylate to oxalate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_389678" ], "products": [ "species_389819", "species_113575" ], "modifiers": [ [ "species_10590419", "catalyst" ] ], "additional_components": [ "species_76629", "Q54E41", "DDB_G0291814" ] }, "reaction_10612523": { "compartment": "compartment_5460", "id": "reaction_10612523", "reactome": "R-DDI-6784224", "name": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784215" ], "products": [ "species_6784241" ], "modifiers": [ [ "species_10612520", "catalyst" ] ], "additional_components": [ "Q86H28", "DDB_G0275669", "species_113596" ] }, "reaction_10590410": { "compartment": "compartment_17951", "id": "reaction_10590410", "reactome": "R-DDI-389826", "name": "glyoxylate + NADPH + H+ => glycolate + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193465", "species_389678", "species_113602" ], "products": [ "species_389822", "species_389556" ], "modifiers": [ [ "species_10590407", "catalyst" ] ], "additional_components": [ "DDB_G0292104" ] }, "reaction_10617423": { "compartment": "compartment_17951", "id": "reaction_10617423", "reactome": "R-DDI-6810076", "name": "DDO oxidizes D-Asp to OA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_6810061" ], "products": [ "species_113575", "species_389843", "species_6810070" ], "modifiers": [ [ "species_10617420", "catalyst" ] ], "additional_components": [ "species_113596", "Q556W1", "DDB_G0273291" ] }, "reaction_10612526": { "compartment": "compartment_5460", "id": "reaction_10612526", "reactome": "R-DDI-6784393", "name": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784236", "species_113587" ], "products": [ "species_6784229", "species_113553" ], "modifiers": [ [ "species_10577869", "catalyst" ] ], "additional_components": [ "Q55F21", "DDB_G0268664" ] }, "reaction_10600929": { "compartment": "compartment_70101", "id": "reaction_10600929", "reactome": "R-DDI-2408551", "name": "SeMet is converted to AdoSeMet by MAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5357707", "species_113592" ], "products": [ "species_111294", "species_29372", "species_5357652" ], "modifiers": [ [ "species_10585496", "catalyst" ] ], "additional_components": [ "Q54F07", "DDB_G0291179", "species_29926", "species_74126" ] }, "reaction_10624111": { "compartment": "compartment_70101", "id": "reaction_10624111", "reactome": "R-DDI-8959510", "name": "SEPHS2 phosphorylates H2Se to form SELP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5357660", "species_29356", "species_113592" ], "products": [ "species_29372", "species_70106", "species_8959518", "species_76577" ], "modifiers": [ [ "species_10624108", "catalyst" ] ], "additional_components": [ "DDB_G0282367" ] }, "reaction_10595831": { "compartment": "compartment_70101", "id": "reaction_10595831", "reactome": "R-DDI-977333", "name": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_977329", "species_29404" ], "products": [ "species_29406", "species_936706" ], "modifiers": [ [ "species_10595828", "catalyst" ] ], "additional_components": [ "Q55CQ6", "DDB_G0269950" ] }, "reaction_10625019": { "compartment": "compartment_70101", "id": "reaction_10625019", "reactome": "R-DDI-9014741", "name": "PXLP-K56-SRR dimer deaminates D-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_376186" ], "products": [ "species_29356", "species_29382", "species_29398" ], "modifiers": [ [ "species_10625016", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54HH2", "DDB_G0289463" ] }, "reaction_10625800": { "compartment": "compartment_70101", "id": "reaction_10625800", "reactome": "R-DDI-9034539", "name": "PXLP-K56-SRR dimer deaminates L-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_29356", "species_29382", "species_29398" ], "modifiers": [ [ "species_10625016", "catalyst" ] ], "additional_components": [ "Q54HH2", "DDB_G0289463" ] }, "reaction_10625022": { "compartment": "compartment_70101", "id": "reaction_10625022", "reactome": "R-DDI-9014766", "name": "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_376186" ], "modifiers": [ [ "species_10625016", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q54HH2", "DDB_G0289463" ] }, "reaction_10595820": { "compartment": "compartment_70101", "id": "reaction_10595820", "reactome": "R-DDI-977324", "name": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_936706" ], "products": [ "species_29372", "species_200736" ], "modifiers": [ [ "species_10595817", "catalyst" ] ], "additional_components": [ "Q54ES3", "DDB_G0291368", "species_29926" ] }, "reaction_10622893": { "compartment": "compartment_70101", "id": "reaction_10622893", "reactome": "R-DDI-8932980", "name": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_8932979" ], "modifiers": [ [ "species_10622882", "catalyst" ] ], "additional_components": [ "DDB_G0281099" ] }, "reaction_10585521": { "compartment": "compartment_70101", "id": "reaction_10585521", "reactome": "R-DDI-174401", "name": "AHCY:NAD+ tetramer hydrolyses AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_71285" ], "products": [ "species_83909", "species_174369" ], "modifiers": [ [ "species_10585518", "catalyst" ] ], "additional_components": [ "species_29360", "P10819", "DDB_G0267418" ] }, "reaction_10598480": { "compartment": "compartment_70101", "id": "reaction_10598480", "reactome": "R-DDI-1614583", "name": "PXLP-K212-CTH cleaves L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614518", "species_29356" ], "products": [ "species_111707", "species_29382", "species_936714" ], "modifiers": [ [ "species_10598474", "catalyst" ] ], "additional_components": [ "Q55DV9", "DDB_G0269122" ] }, "reaction_10598454": { "compartment": "compartment_70101", "id": "reaction_10598454", "reactome": "R-DDI-1614524", "name": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736", "species_174369" ], "products": [ "species_1614518", "species_29356" ], "modifiers": [ [ "species_10598451", "catalyst" ] ], "additional_components": [ "species_917877", "P46794", "DDB_G0267386" ] }, "reaction_10585499": { "compartment": "compartment_70101", "id": "reaction_10585499", "reactome": "R-DDI-174391", "name": "MAT1A multimers transfer Ado from ATP to L-Met", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_174390" ], "products": [ "species_111294", "species_29372", "species_71284" ], "modifiers": [ [ "species_10585496", "catalyst" ] ], "additional_components": [ "Q54F07", "DDB_G0291179", "species_29926", "species_74126" ] }, "reaction_10585483": { "compartment": "compartment_70101", "id": "reaction_10585483", "reactome": "R-DDI-174374", "name": "MTR transfers CH3 from MeCbl to HCYS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585476", "species_174369" ], "products": [ "species_10585480", "species_174390" ], "modifiers": [ [ "species_10585476", "catalyst" ] ], "additional_components": [ "Q54P92", "DDB_G0284699", "species_29426", "CHEBI:28115", "species_76629", "Q55G48", "DDB_G0267824", "species_113596", "Q54P92", "DDB_G0284699", "species_29426", "species_3159260", "species_76629", "Q55G48", "DDB_G0267824", "species_113596", "Q54P92", "DDB_G0284699", "species_29426", "CHEBI:28115", "species_76629", "Q55G48", "DDB_G0267824", "species_113596" ] }, "reaction_10597296": { "compartment": "compartment_70101", "id": "reaction_10597296", "reactome": "R-DDI-1237096", "name": "Methylthio-ribose-P = Methylthio-ribulose-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1237165" ], "products": [ "species_1237107" ], "modifiers": [ [ "species_10597293", "catalyst" ] ], "additional_components": [ "DDB_G0283309" ] }, "reaction_10597316": { "compartment": "compartment_70101", "id": "reaction_10597316", "reactome": "R-DDI-1237129", "name": "Acireductone is created", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1237176" ], "products": [ "species_29372", "species_70106", "species_1237155" ], "modifiers": [ [ "species_10597313", "catalyst" ] ], "additional_components": [ "species_29926", "Q55FM6", "DDB_G0268036" ] }, "reaction_10597306": { "compartment": "compartment_70101", "id": "reaction_10597306", "reactome": "R-DDI-1237119", "name": "Acireductone is oxidized to MOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_1237155" ], "products": [ "species_29460", "species_1237122" ], "modifiers": [ [ "species_10597303", "catalyst" ] ], "additional_components": [ "Q54ER6", "DDB_G0291376", "species_71067" ] }, "reaction_10577831": { "compartment": "compartment_70101", "id": "reaction_10577831", "reactome": "R-DDI-70523", "name": "PXLP-K314-GPT transaminates L-Ala to form PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29432" ], "products": [ "species_29404", "species_29398" ], "modifiers": [ [ "species_10577828", "catalyst" ] ], "additional_components": [ "Q54MJ7", "DDB_G0285899" ] }, "reaction_10593878": { "compartment": "compartment_5460", "id": "reaction_10593878", "reactome": "R-DDI-507749", "name": "PXLP-K341-GPT2 transaminates PYR to form L-Ala", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113557", "species_113552" ], "products": [ "species_113594", "species_379697" ], "modifiers": [ [ "species_10593875", "catalyst" ] ], "additional_components": [ "Q54MJ7", "DDB_G0285899" ] }, "reaction_10588674": { "compartment": "compartment_70101", "id": "reaction_10588674", "reactome": "R-DDI-209823", "name": "Tyrosine is hydroxylated to dopa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_29368", "species_29506" ], "products": [ "species_209849", "species_71112" ], "modifiers": [ [ "species_10588671", "catalyst" ] ], "additional_components": [ "species_71067", "Q54XS1", "DDB_G0278781" ] }, "reaction_10611411": { "compartment": "compartment_876", "id": "reaction_10611411", "reactome": "R-DDI-5693681", "name": "DUOX1,2 reduce O2 to H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_351627", "species_352327" ], "products": [ "species_351628", "species_351629" ], "modifiers": [ [ "species_10611408", "catalyst" ] ], "additional_components": [ "Q54F44", "DDB_G0291117", "Q86GL4", "DDB_G0287101", "Q9XYS3", "DDB_G0289653" ] }, "reaction_10589347": { "compartment": "compartment_984", "id": "reaction_10589347", "reactome": "R-DDI-350901", "name": "Iodide is organified", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_351627", "species_209818", "species_351629" ], "products": [ "species_109276", "species_351630", "species_351628" ], "modifiers": [ [ "species_10588619", "catalyst" ] ], "additional_components": [ "DDB_G0277275" ] }, "reaction_10588692": { "compartment": "compartment_984", "id": "reaction_10588692", "reactome": "R-DDI-209925", "name": "DIT and MIT combine to form triiodothyronine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352329", "species_351639" ], "products": [ "species_352331", "species_352036" ], "modifiers": [ [ "species_10588619", "catalyst" ] ], "additional_components": [ "DDB_G0277275" ] }, "reaction_10588694": { "compartment": "compartment_984", "id": "reaction_10588694", "reactome": "R-DDI-209973", "name": "Tyrosine is diiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_351627", "species_352030", "species_209818", "species_351629" ], "products": [ "species_109276", "species_352329", "species_351628" ], "modifiers": [ [ "species_10588619", "catalyst" ] ], "additional_components": [ "DDB_G0277275" ] }, "reaction_10589345": { "compartment": "compartment_70101", "id": "reaction_10589345", "reactome": "R-DDI-350869", "name": "Thyroxine is deiodinated to reverse triiodothyronine (RT3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_209937" ], "products": [ "species_209785", "species_176667", "species_29366" ], "modifiers": [ [ "species_10589342", "catalyst" ] ], "additional_components": [ "DDB_G0275741" ] }, "reaction_10588614": { "compartment": "compartment_70101", "id": "reaction_10588614", "reactome": "R-DDI-209772", "name": "Thyroxine is deiodinated to triiodothyronine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_209937" ], "products": [ "species_209785", "species_176667", "species_29366" ], "modifiers": [ [ "species_10588611", "catalyst" ] ], "additional_components": [ "Q552Y2", "DDB_G0275741" ] }, "reaction_10588685": { "compartment": "compartment_984", "id": "reaction_10588685", "reactome": "R-DDI-209840", "name": "Two DITs combine to form thyroxine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352329" ], "products": [ "species_352326", "species_352036" ], "modifiers": [ [ "species_10588619", "catalyst" ] ], "additional_components": [ "DDB_G0277275" ] }, "reaction_10588622": { "compartment": "compartment_984", "id": "reaction_10588622", "reactome": "R-DDI-209815", "name": "Tyrosine is monoiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351630", "species_352030" ], "products": [ "species_622410", "species_351639" ], "modifiers": [ [ "species_10588619", "catalyst" ] ], "additional_components": [ "DDB_G0277275" ] }, "reaction_10612514": { "compartment": "compartment_70101", "id": "reaction_10612514", "reactome": "R-DDI-6783955", "name": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_35305", "species_29364" ], "products": [ "species_29366", "species_113538" ], "modifiers": [ [ "species_10612511", "catalyst" ] ], "additional_components": [ "Q54IL7", "DDB_G0288671" ] }, "reaction_10577861": { "compartment": "compartment_5460", "id": "reaction_10577861", "reactome": "R-DDI-70589", "name": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_517496", "species_113594", "species_113529", "species_113561" ], "products": [ "species_113552", "species_113521", "species_517495" ], "modifiers": [ [ "species_10577858", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_29364", "species_192305", "species_29360", "species_29366", "Q54KB7", "DDB_G0287469" ] }, "reaction_10594292": { "compartment": "compartment_70101", "id": "reaction_10594292", "reactome": "R-DDI-893616", "name": "glutamine + pyruvate => 2-oxoglutaramate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398", "species_29472" ], "products": [ "species_29432", "species_893598" ], "modifiers": [ [ "species_10594283", "catalyst" ] ], "additional_components": [ "Q54KM6", "DDB_G0287269" ] }, "reaction_10577927": { "compartment": "compartment_5460", "id": "reaction_10577927", "reactome": "R-DDI-70664", "name": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113590", "species_29362" ], "products": [ "species_113526", "species_379717" ], "modifiers": [ [ "species_10577924", "catalyst" ] ], "additional_components": [ "Q54IL7", "DDB_G0288671" ] }, "reaction_10577929": { "compartment": "compartment_5460", "id": "reaction_10577929", "reactome": "R-DDI-70666", "name": "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31339", "species_113552" ], "products": [ "species_113594", "species_113585" ], "modifiers": [ [ "species_10577914", "catalyst" ] ], "additional_components": [ "Q54JP5", "DDB_G0287913" ] }, "reaction_10612507": { "compartment": "compartment_5460", "id": "reaction_10612507", "reactome": "R-DDI-6783939", "name": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113590", "species_29362" ], "products": [ "species_113526", "species_379717" ], "modifiers": [ [ "species_10612504", "catalyst" ] ], "additional_components": [ "Q54IL7", "DDB_G0288671" ] }, "reaction_10577884": { "compartment": "compartment_5460", "id": "reaction_10577884", "reactome": "R-DDI-70600", "name": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113552", "species_113521", "species_517495" ], "products": [ "species_517496", "species_113594", "species_113529", "species_113561" ], "modifiers": [ [ "species_10577858", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_29360", "species_29366", "species_29364", "species_192305", "Q54KB7", "DDB_G0287469" ] }, "reaction_10578387": { "compartment": "compartment_70101", "id": "reaction_10578387", "reactome": "R-DDI-71164", "name": "homogentisate + O2 => maleylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_30337" ], "products": [ "species_31135" ], "modifiers": [ [ "species_10578384", "catalyst" ] ], "additional_components": [ "species_71067", "Q54QI4", "DDB_G0283765" ] }, "reaction_10578407": { "compartment": "compartment_70101", "id": "reaction_10578407", "reactome": "R-DDI-71181", "name": "fumarylacetoacetate => fumarate + acetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_31175" ], "products": [ "species_29666", "species_29586" ], "modifiers": [ [ "species_10578404", "catalyst" ] ], "additional_components": [ "Q1ZXQ1", "DDB_G0271094" ] }, "reaction_10578358": { "compartment": "compartment_70101", "id": "reaction_10578358", "reactome": "R-DDI-71155", "name": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29506" ], "products": [ "species_29404", "species_31365" ], "modifiers": [ [ "species_10578355", "catalyst" ] ], "additional_components": [ "Q54K95", "DDB_G0287515" ] }, "reaction_10578377": { "compartment": "compartment_70101", "id": "reaction_10578377", "reactome": "R-DDI-71163", "name": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_31365" ], "products": [ "species_113528", "species_30337" ], "modifiers": [ [ "species_10578374", "catalyst" ] ], "additional_components": [ "Q76NV5", "DDB_G0277511", "Q557J8", "DDB_G0273429", "species_198816", "species_71067" ] }, "reaction_10578397": { "compartment": "compartment_70101", "id": "reaction_10578397", "reactome": "R-DDI-71173", "name": "maleylacetoacetate => fumarylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31135" ], "products": [ "species_31175" ], "modifiers": [ [ "species_10578394", "catalyst" ] ], "additional_components": [ "Q54YN2", "DDB_G0278155", "species_29450" ] }, "reaction_10600401": { "compartment": "compartment_984", "id": "reaction_10600401", "reactome": "R-DDI-2160492", "name": "IL4I1:FAD oxidises L-Phe to kPPV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_351993", "species_352327" ], "products": [ "species_2022135", "species_351629", "species_2160466" ], "modifiers": [ [ "species_10600398", "catalyst" ] ], "additional_components": [ "species_113596", "Q54EW2", "DDB_G0293662", "Q55B17", "DDB_G0293662", "Q54BE7", "DDB_G0293662", "Q55B19", "DDB_G0293662" ] }, "reaction_10578320": { "compartment": "compartment_70101", "id": "reaction_10578320", "reactome": "R-DDI-71118", "name": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_29502", "species_29368" ], "products": [ "species_71112", "species_29506" ], "modifiers": [ [ "species_10578317", "catalyst" ] ], "additional_components": [ "Q54XS1", "DDB_G0278781", "species_71067" ] }, "reaction_10578347": { "compartment": "compartment_70101", "id": "reaction_10578347", "reactome": "R-DDI-71146", "name": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71112" ], "products": [ "species_29356", "species_71129" ], "modifiers": [ [ "species_10578344", "catalyst" ] ], "additional_components": [ "Q54XF6", "DDB_G0278993", "Q54RY8", "DDB_G0282831" ] }, "reaction_10578330": { "compartment": "compartment_70101", "id": "reaction_10578330", "reactome": "R-DDI-71130", "name": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_71129", "species_73473" ], "products": [ "species_29870", "species_29360" ], "modifiers": [ [ "species_10578327", "catalyst" ] ], "additional_components": [ "Q86A17", "DDB_G0272684" ] }, "reaction_10594286": { "compartment": "compartment_70101", "id": "reaction_10594286", "reactome": "R-DDI-893593", "name": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29502", "species_29398" ], "products": [ "species_29432", "species_893599" ], "modifiers": [ [ "species_10594283", "catalyst" ] ], "additional_components": [ "Q54KM6", "DDB_G0287269" ] }, "reaction_10577841": { "compartment": "compartment_5460", "id": "reaction_10577841", "reactome": "R-DDI-70542", "name": "glutamate + acetyl CoA => N-acetyl glutamate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559", "species_113552" ], "products": [ "species_29374", "species_30471" ], "modifiers": [ [ "species_10577838", "catalyst" ], [ "species_374064", "catalyst" ] ], "additional_components": [ "DDB_G0286257" ] }, "reaction_10577906": { "compartment": "compartment_70101", "id": "reaction_10577906", "reactome": "R-DDI-70634", "name": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113567", "species_29498" ], "products": [ "species_113585", "species_29968" ], "modifiers": [ [ "species_10577903", "catalyst" ] ], "additional_components": [ "Q54FE6", "DDB_G0290913", "Q55E85", "DDB_G0269352", "Q86HN8", "DDB_G0274501" ] }, "reaction_10593352": { "compartment": "compartment_5460", "id": "reaction_10593352", "reactome": "R-DDI-452036", "name": "arginine + H2O => ornithine + urea [ARG2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_374064", "species_113521" ], "products": [ "species_374061", "species_113585" ], "modifiers": [ [ "species_10593349", "catalyst" ] ], "additional_components": [ "Q54HV8", "DDB_G0289195", "species_266099" ] }, "reaction_10577851": { "compartment": "compartment_70101", "id": "reaction_10577851", "reactome": "R-DDI-70569", "name": "arginine + H2O => ornithine + urea [ARG1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29468" ], "products": [ "species_29514", "species_29498" ], "modifiers": [ [ "species_10577848", "catalyst" ] ], "additional_components": [ "Q54HV8", "DDB_G0289195", "species_266099" ] }, "reaction_10577872": { "compartment": "compartment_5460", "id": "reaction_10577872", "reactome": "R-DDI-70596", "name": "GOT2 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113553" ], "products": [ "species_113587", "species_113552" ], "modifiers": [ [ "species_10577869", "catalyst" ] ], "additional_components": [ "Q55F21", "DDB_G0268664" ] }, "reaction_10613589": { "compartment": "compartment_70101", "id": "reaction_10613589", "reactome": "R-DDI-6797627", "name": "ASPG hydrolyses L-Asn to L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29642" ], "products": [ "species_29448", "species_29382" ], "modifiers": [ [ "species_10613586", "catalyst" ] ], "additional_components": [ "DDB_G0271924" ] }, "reaction_10577882": { "compartment": "compartment_70101", "id": "reaction_10577882", "reactome": "R-DDI-70599", "name": "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_29448", "species_29472" ], "products": [ "species_111294", "species_29404", "species_29642", "species_76577" ], "modifiers": [ [ "species_10577879", "catalyst" ] ], "additional_components": [ "Q54MB4", "DDB_G0286059" ] }, "reaction_10623961": { "compartment": "compartment_5460", "id": "reaction_10623961", "reactome": "R-DDI-8954468", "name": "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559", "species_113553" ], "products": [ "species_29374", "species_8954466", "species_113529" ], "modifiers": [ [ "species_10623958", "catalyst" ] ], "additional_components": [ "Q54IG0", "DDB_G0293514", "Q54BP5", "DDB_G0293514" ] }, "reaction_10578417": { "compartment": "compartment_70101", "id": "reaction_10578417", "reactome": "R-DDI-71188", "name": "TDO tetramer dioxygenates L-Trp to NFK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29500", "species_29368" ], "products": [ "species_33179" ], "modifiers": [ [ "species_10578414", "catalyst" ] ], "additional_components": [ "species_917877", "Q55DB4", "DDB_G0269714" ] }, "reaction_10594289": { "compartment": "compartment_70101", "id": "reaction_10594289", "reactome": "R-DDI-893596", "name": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398", "species_29970" ], "products": [ "species_29432", "species_893615" ], "modifiers": [ [ "species_10594283", "catalyst" ], [ "species_29502", "inhibitor" ], [ "species_8939576", "inhibitor" ] ], "additional_components": [ "Q54KM6", "DDB_G0287269", "CHEBI:55528", "CHEBI:43580" ] }, "reaction_10594275": { "compartment": "compartment_5460", "id": "reaction_10594275", "reactome": "R-DDI-893583", "name": "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_893607" ], "products": [ "species_893617", "species_113552" ], "modifiers": [ [ "species_10578160", "catalyst" ] ], "additional_components": [ "Q54K00", "DDB_G0287711" ] }, "reaction_10578436": { "compartment": "compartment_70101", "id": "reaction_10578436", "reactome": "R-DDI-71217", "name": "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_34351", "species_29356" ], "products": [ "species_29432", "species_30487" ], "modifiers": [ [ "species_10578433", "catalyst" ] ], "additional_components": [ "Q54Q04", "DDB_G0284203" ] }, "reaction_10578425": { "compartment": "compartment_70101", "id": "reaction_10578425", "reactome": "R-DDI-71200", "name": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_29970" ], "products": [ "species_34351", "species_29356", "species_29366" ], "modifiers": [ [ "species_10578422", "catalyst" ] ], "additional_components": [ "DDB_G0283173" ] }, "reaction_10620687": { "compartment": "compartment_876", "id": "reaction_10620687", "reactome": "R-DDI-8870352", "name": "SLC36A4 transports L-Trp from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352006" ], "products": [ "species_29500" ], "modifiers": [ [ "species_10620684", "catalyst" ] ], "additional_components": [ "DDB_G0293074" ] }, "reaction_10578446": { "compartment": "compartment_70101", "id": "reaction_10578446", "reactome": "R-DDI-71218", "name": "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_30487" ], "products": [ "species_36027" ], "modifiers": [ [ "species_10578443", "catalyst" ] ], "additional_components": [ "Q54S02", "DDB_G0282743", "species_71067" ] }, "reaction_10606628": { "compartment": "compartment_5668575", "id": "reaction_10606628", "reactome": "R-DDI-5662662", "name": "Tyrosinase oxidises tyrosine to dopaquinone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5668573", "species_5668567" ], "products": [ "species_5668577", "species_5662695" ], "modifiers": [ [ "species_10606620", "catalyst" ], [ "species_10606626", "catalyst" ] ], "additional_components": [ "Q54QT0", "DDB_G0283653", "Q54QT1", "DDB_G0283653", "species_437295", "DDB_G0276801" ] }, "reaction_10606612": { "compartment": "compartment_5668572", "id": "reaction_10606612", "reactome": "R-DDI-5662660", "name": "Dopachrome is transformed to DHICA by DCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5662665" ], "products": [ "species_5662670" ], "modifiers": [ [ "species_10606609", "catalyst" ] ], "additional_components": [ "species_29426", "Q54QT0", "DDB_G0283653", "Q54QT1", "DDB_G0283653" ] }, "reaction_10606631": { "compartment": "compartment_5668572", "id": "reaction_10606631", "reactome": "R-DDI-5662692", "name": "Dopa is oxidized to dopaquinone by TYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5668568", "species_5668566" ], "products": [ "species_5668574", "species_5662695" ], "modifiers": [ [ "species_10606620", "catalyst" ] ], "additional_components": [ "Q54QT0", "DDB_G0283653", "Q54QT1", "DDB_G0283653", "species_437295" ] }, "reaction_10606633": { "compartment": "compartment_5668572", "id": "reaction_10606633", "reactome": "R-DDI-5663050", "name": "DHI and DHICA polymerise forming eumelanin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5662708", "species_5662695" ], "products": [ "species_5668568", "species_5662678" ], "modifiers": [ [ "species_10606620", "catalyst" ] ], "additional_components": [ "species_5662670", "CHEBI:27404", "species_5662670", "CHEBI:27404", "Q54QT0", "DDB_G0283653", "Q54QT1", "DDB_G0283653", "species_437295" ] }, "reaction_10622761": { "compartment": "compartment_5668575", "id": "reaction_10622761", "reactome": "R-DDI-8878581", "name": "TYRP1 oxidises DHICA to IQCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5662670", "species_5668566" ], "products": [ "species_8878586", "species_5668574" ], "modifiers": [ [ "species_10622758", "catalyst" ] ], "additional_components": [ "Q54QT0", "DDB_G0283653", "Q54QT1", "DDB_G0283653" ] }, "reaction_10578017": { "compartment": "compartment_5460", "id": "reaction_10578017", "reactome": "R-DDI-70785", "name": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70772", "species_113521" ], "products": [ "species_70784" ], "modifiers": [ [ "species_10578014", "catalyst" ] ], "additional_components": [ "Q54HG7", "DDB_G0289471" ] }, "reaction_10593920": { "compartment": "compartment_5460", "id": "reaction_10593920", "reactome": "R-DDI-508369", "name": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_70836", "species_29362" ], "products": [ "species_70829", "species_113526" ], "modifiers": [ [ "species_10578034", "catalyst" ] ], "additional_components": [ "Q86JE3", "DDB_G0272128" ] }, "reaction_10593922": { "compartment": "compartment_5460", "id": "reaction_10593922", "reactome": "R-DDI-508473", "name": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_30004", "species_29362" ], "products": [ "species_113526", "species_573404" ], "modifiers": [ [ "species_10578082", "catalyst" ] ], "additional_components": [ "Q54CX6", "DDB_G0292566" ] }, "reaction_10577989": { "compartment": "compartment_70101", "id": "reaction_10577989", "reactome": "R-DDI-70723", "name": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_508182" ], "products": [ "species_29404", "species_508187" ], "modifiers": [ [ "species_10577986", "catalyst" ] ], "additional_components": [ "species_29588", "CHEBI:58045", "CHEBI:57762", "CHEBI:28654", "CHEBI:17865", "CHEBI:16530", "Q54N47", "DDB_G0285509" ] }, "reaction_10578057": { "compartment": "compartment_5460", "id": "reaction_10578057", "reactome": "R-DDI-70859", "name": "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70851" ], "products": [ "species_70858", "species_31649" ], "modifiers": [ [ "species_10578054", "catalyst" ] ], "additional_components": [ "Q54IM8", "DDB_G0288647", "species_113596" ] }, "reaction_10578027": { "compartment": "compartment_5460", "id": "reaction_10578027", "reactome": "R-DDI-70800", "name": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70718", "species_113596" ], "products": [ "species_70799", "species_31649" ], "modifiers": [ [ "species_10578024", "catalyst" ] ], "additional_components": [ "Q54RR5", "DDB_G0282967", "species_113596" ] }, "reaction_10577997": { "compartment": "compartment_5460", "id": "reaction_10577997", "reactome": "R-DDI-70724", "name": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_508190" ], "products": [ "species_508181", "species_113552" ], "modifiers": [ [ "species_10577994", "catalyst" ] ], "additional_components": [ "CHEBI:58045", "CHEBI:57762", "species_29588", "CHEBI:16530", "CHEBI:28654", "CHEBI:17865", "Q54N47", "DDB_G0285509" ] }, "reaction_10578093": { "compartment": "compartment_5460", "id": "reaction_10578093", "reactome": "R-DDI-70893", "name": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_30004" ], "products": [ "species_70843", "species_113529", "species_29362", "species_29376" ], "modifiers": [ [ "species_10578090", "catalyst" ] ], "additional_components": [ "DDB_G0289085" ] }, "reaction_10578067": { "compartment": "compartment_5460", "id": "reaction_10578067", "reactome": "R-DDI-70870", "name": "ECHS1 hydrates methacrylyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70858", "species_113521" ], "products": [ "species_71847" ], "modifiers": [ [ "species_10578064", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10578007": { "compartment": "compartment_5460", "id": "reaction_10578007", "reactome": "R-DDI-70745", "name": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70715" ], "products": [ "species_70744", "species_31649" ], "modifiers": [ [ "species_10578004", "catalyst" ] ], "additional_components": [ "Q54W88", "DDB_G0279827", "species_113596" ] }, "reaction_10578075": { "compartment": "compartment_5460", "id": "reaction_10578075", "reactome": "R-DDI-70881", "name": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71847", "species_113521" ], "products": [ "species_29374", "species_573404" ], "modifiers": [ [ "species_10578072", "catalyst" ] ], "additional_components": [ "DDB_G0267536" ] }, "reaction_10577978": { "compartment": "compartment_5460", "id": "reaction_10577978", "reactome": "R-DDI-70713", "name": "BCKDH transfers CoA group from CoA-SH to BCAAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_508181" ], "products": [ "species_29362", "species_508261", "species_29376" ], "modifiers": [ [ "species_10577975", "catalyst" ] ], "additional_components": [ "CHEBI:16530", "CHEBI:28654", "CHEBI:17865", "species_70851", "species_70715", "species_70718", "Q54TR7", "DDB_G0281797", "Q55FN7", "DDB_G0268020", "species_8878387", "Q54M22", "DDB_G0286335", "Q54EW8", "DDB_G0291648", "species_113596" ] }, "reaction_10578047": { "compartment": "compartment_5460", "id": "reaction_10578047", "reactome": "R-DDI-70844", "name": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_70836" ], "products": [ "species_70843", "species_113559" ], "modifiers": [ [ "species_10578044", "catalyst" ] ], "additional_components": [ "Q86AD9", "DDB_G0271544" ] }, "reaction_10589365": { "compartment": "compartment_70101", "id": "reaction_10589365", "reactome": "R-DDI-351215", "name": "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353113", "species_29610" ], "products": [ "species_204635", "species_353106" ], "modifiers": [ [ "species_10589362", "catalyst" ] ], "additional_components": [ "DDB_G0268630" ] }, "reaction_10589355": { "compartment": "compartment_70101", "id": "reaction_10589355", "reactome": "R-DDI-351207", "name": "Spermine => N-acetylated spermine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353560", "species_76183" ], "products": [ "species_76194", "species_353575" ], "modifiers": [ [ "species_10589352", "catalyst" ] ], "additional_components": [ "DDB_G0279851" ] }, "reaction_10589357": { "compartment": "compartment_70101", "id": "reaction_10589357", "reactome": "R-DDI-351208", "name": "Spermidine => N-acetylated spermidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_204635", "species_76183" ], "products": [ "species_353555", "species_76194" ], "modifiers": [ [ "species_10589352", "catalyst" ] ], "additional_components": [ "DDB_G0279851" ] }, "reaction_10577946": { "compartment": "compartment_70101", "id": "reaction_10577946", "reactome": "R-DDI-70692", "name": "ornithine => putrescine + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29498" ], "products": [ "species_29610", "species_113528" ], "modifiers": [ [ "species_10577943", "catalyst" ] ], "additional_components": [ "DDB_G0281109" ] }, "reaction_10589373": { "compartment": "compartment_70101", "id": "reaction_10589373", "reactome": "R-DDI-351222", "name": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284" ], "products": [ "species_353113", "species_113528" ], "modifiers": [ [ "species_10589370", "catalyst" ] ], "additional_components": [ "DDB_G0275567" ] }, "reaction_10578163": { "compartment": "compartment_5460", "id": "reaction_10578163", "reactome": "R-DDI-70952", "name": "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_508531" ], "products": [ "species_70951", "species_113552" ], "modifiers": [ [ "species_10578160", "catalyst" ] ], "additional_components": [ "Q54K00", "DDB_G0287711" ] }, "reaction_10612802": { "compartment": "compartment_5460", "id": "reaction_10612802", "reactome": "R-DDI-6788611", "name": "HYKK phosphorylates 5HLYS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788606", "species_113573" ], "products": [ "species_5696409", "species_113525" ], "modifiers": [ [ "species_10612799", "catalyst" ] ], "additional_components": [ "DDB_G0295739" ] }, "reaction_10612500": { "compartment": "compartment_17951", "id": "reaction_10612500", "reactome": "R-DDI-6783880", "name": "PIPOX oxidises PPCA to P6C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_5693325" ], "products": [ "species_113575", "species_6783877" ], "modifiers": [ [ "species_10612497", "catalyst" ] ], "additional_components": [ "DDB_G0280851" ] }, "reaction_10589556": { "compartment": "compartment_5460", "id": "reaction_10589556", "reactome": "R-DDI-372480", "name": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113577" ], "products": [ "species_29406", "species_70951" ], "modifiers": [ [ "species_10589553", "catalyst" ] ], "additional_components": [ "DDB_G0267704" ] }, "reaction_10578310": { "compartment": "compartment_5460", "id": "reaction_10578310", "reactome": "R-DDI-71046", "name": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70955" ], "products": [ "species_71045", "species_31649", "species_29376" ], "modifiers": [ [ "species_10578307", "catalyst" ] ], "additional_components": [ "Q54R47", "DDB_G0283411", "species_113596" ] }, "reaction_10578152": { "compartment": "compartment_5460", "id": "reaction_10578152", "reactome": "R-DDI-70941", "name": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_113556", "species_113521" ], "products": [ "species_113529", "species_508531", "species_29362" ], "modifiers": [ [ "species_10578149", "catalyst" ] ], "additional_components": [ "P83401", "DDB_G0276821" ] }, "reaction_10578139": { "compartment": "compartment_5460", "id": "reaction_10578139", "reactome": "R-DDI-70938", "name": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113529", "species_29444", "species_113600" ], "products": [ "species_113563", "species_113521", "species_30176" ], "modifiers": [ [ "species_10578136", "catalyst" ] ], "additional_components": [ "Q54NG9", "DDB_G0285267" ] }, "reaction_10611324": { "compartment": "compartment_17951", "id": "reaction_10611324", "reactome": "R-DDI-5693347", "name": "CRYM reduces P2C to PPCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193465", "species_5693311", "species_113602" ], "products": [ "species_5693325", "species_389556" ], "modifiers": [ [ "species_10611321", "catalyst" ] ], "additional_components": [ "DDB_G0292894" ] }, "reaction_10578300": { "compartment": "compartment_5460", "id": "reaction_10578300", "reactome": "R-DDI-71037", "name": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_70951" ], "products": [ "species_70955", "species_29362", "species_29376" ], "modifiers": [ [ "species_10578297", "catalyst" ] ], "additional_components": [ "CHEBI:17460", "Q869Y7", "DDB_G0275029", "Q54JE4", "DDB_G0288127", "species_8878387", "Q54EW8", "DDB_G0291648", "species_113596" ] }, "reaction_10578142": { "compartment": "compartment_5460", "id": "reaction_10578142", "reactome": "R-DDI-70940", "name": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_113521", "species_30176" ], "products": [ "species_113529", "species_113556", "species_29362", "species_113552" ], "modifiers": [ [ "species_10578136", "catalyst" ] ], "additional_components": [ "Q54NG9", "DDB_G0285267" ] }, "reaction_10578129": { "compartment": "compartment_70101", "id": "reaction_10578129", "reactome": "R-DDI-70920", "name": "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30158", "species_111355" ], "products": [ "species_29404", "species_70919" ], "modifiers": [ [ "species_10578126", "catalyst" ] ], "additional_components": [ "Q54JL3", "DDB_G0287977" ] }, "reaction_10578101": { "compartment": "compartment_70101", "id": "reaction_10578101", "reactome": "R-DDI-70899", "name": "histidine => urocanate + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29612" ], "products": [ "species_31633", "species_30721" ], "modifiers": [ [ "species_10578098", "catalyst" ] ], "additional_components": [ "DDB_G0288025" ] }, "reaction_10578119": { "compartment": "compartment_70101", "id": "reaction_10578119", "reactome": "R-DDI-70906", "name": "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_34979" ], "products": [ "species_30158", "species_70106" ], "modifiers": [ [ "species_10578116", "catalyst" ] ], "additional_components": [ "DDB_G0269854" ] }, "reaction_10622372": { "compartment": "compartment_70101", "id": "reaction_10622372", "reactome": "R-DDI-8876789", "name": "CARNMT1 methylates CARN to Anserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6786250", "species_71284" ], "products": [ "species_71285", "species_8876775" ], "modifiers": [ [ "species_10622369", "catalyst" ] ], "additional_components": [ "DDB_G0282239" ] }, "reaction_10578111": { "compartment": "compartment_70101", "id": "reaction_10578111", "reactome": "R-DDI-70903", "name": "urocanate + H2O => 4-imidazolone-5-propionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30721" ], "products": [ "species_34979" ], "modifiers": [ [ "species_10578108", "catalyst" ] ], "additional_components": [ "species_29360", "Q86AX3", "DDB_G0277727" ] }, "reaction_10613621": { "compartment": "compartment_70101", "id": "reaction_10613621", "reactome": "R-DDI-6797956", "name": "SLC44A1 transports Cho from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264618" ], "products": [ "species_6798162" ], "modifiers": [ [ "species_10613618", "catalyst" ] ], "additional_components": [ "Q54IJ2", "DDB_G0288717", "Q54I48", "DDB_G0289013" ] }, "reaction_10613629": { "compartment": "compartment_5460", "id": "reaction_10613629", "reactome": "R-DDI-6797961", "name": "CHDH oxidises Cho to BETALD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_6798162" ], "products": [ "species_6798194", "species_31649" ], "modifiers": [ [ "species_10613626", "catalyst" ] ], "additional_components": [ "DDB_G0287229" ] }, "reaction_10613612": { "compartment": "compartment_5460", "id": "reaction_10613612", "reactome": "R-DDI-6797955", "name": "ALDH7A1 oxidises BETALD to BET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_6798194", "species_113521" ], "products": [ "species_6798202", "species_29362" ], "modifiers": [ [ "species_10578147", "catalyst" ] ], "additional_components": [ "DDB_G0276821" ] }, "reaction_10580773": { "compartment": "compartment_5460", "id": "reaction_10580773", "reactome": "R-DDI-73916", "name": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559" ], "products": [ "species_29374", "species_73871" ], "modifiers": [ [ "species_10578044", "catalyst" ] ], "additional_components": [ "Q86AD9", "DDB_G0271544" ] }, "reaction_10621991": { "compartment": "compartment_5460", "id": "reaction_10621991", "reactome": "R-DDI-8875071", "name": "ACSS3 ligates CoA to CH3COO-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_113539" ], "products": [ "species_159448", "species_159450", "species_113559" ], "modifiers": [ [ "species_10621988", "catalyst" ] ], "additional_components": [ "DDB_G0274939" ] }, "reaction_10580788": { "compartment": "compartment_5460", "id": "reaction_10580788", "reactome": "R-DDI-73918", "name": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73871", "species_113559" ], "products": [ "species_29374", "species_73917" ], "modifiers": [ [ "species_10580785", "catalyst" ] ], "additional_components": [ "P54872", "DDB_G0288461", "Q86HL5", "DDB_G0274871" ] }, "reaction_10581175": { "compartment": "compartment_5460", "id": "reaction_10581175", "reactome": "R-DDI-74180", "name": "HMG CoA => acetoacetic acid + acetyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73917" ], "products": [ "species_113559", "species_73909" ], "modifiers": [ [ "species_10581172", "catalyst" ] ], "additional_components": [ "Q54QI7", "DDB_G0283813" ] }, "reaction_10612794": { "compartment": "compartment_70101", "id": "reaction_10612794", "reactome": "R-DDI-6788597", "name": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191374" ], "products": [ "species_76183", "species_29666" ], "modifiers": [ [ "species_10612791", "catalyst" ] ], "additional_components": [ "Q54QI7", "DDB_G0283813", "species_29926" ] }, "reaction_10581165": { "compartment": "compartment_5460", "id": "reaction_10581165", "reactome": "R-DDI-74177", "name": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70958", "species_73909" ], "products": [ "species_73871", "species_113536" ], "modifiers": [ [ "species_10581162", "catalyst" ] ], "additional_components": [ "Q54JD9", "DDB_G0288105" ] }, "reaction_10600081": { "compartment": "compartment_17957", "id": "reaction_10600081", "reactome": "R-DDI-2046088", "name": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046052", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2046051", "species_162743", "species_159751" ], "modifiers": [ [ "species_10593966", "catalyst" ] ], "additional_components": [ "Q55BY4", "DDB_G0271066", "C7FZW5", "DDB_G0271066" ] }, "reaction_10600112": { "compartment": "compartment_17951", "id": "reaction_10600112", "reactome": "R-DDI-2066778", "name": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_2066767" ], "products": [ "species_2066766" ], "modifiers": [ [ "species_10586623", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10600083": { "compartment": "compartment_17957", "id": "reaction_10600083", "reactome": "R-DDI-2046090", "name": "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046057", "species_113601" ], "products": [ "species_113519", "species_2046065", "species_113564", "species_162743", "species_159751" ], "modifiers": [ [ "species_10593964", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10600114": { "compartment": "compartment_17951", "id": "reaction_10600114", "reactome": "R-DDI-2066780", "name": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2066766" ], "products": [ "species_2066762" ], "modifiers": [ [ "species_10586623", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10600116": { "compartment": "compartment_17951", "id": "reaction_10600116", "reactome": "R-DDI-2066787", "name": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_2046047" ], "products": [ "species_113575", "species_2066767" ], "modifiers": [ [ "species_10590470", "catalyst" ] ], "additional_components": [ "Q54GQ6", "DDB_G0289993", "species_113596" ] }, "reaction_10600119": { "compartment": "compartment_17951", "id": "reaction_10600119", "reactome": "R-DDI-2066788", "name": "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193514", "species_2066762" ], "products": [ "species_353123", "species_2066765" ], "modifiers": [ [ "species_10590457", "catalyst" ] ], "additional_components": [ "DDB_G0274339" ] }, "reaction_10600093": { "compartment": "compartment_12045", "id": "reaction_10600093", "reactome": "R-DDI-2046100", "name": "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046059", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2046057", "species_162743", "species_159751" ], "modifiers": [ [ "species_10593964", "catalyst" ] ], "additional_components": [ "C7FZW5", "DDB_G0271066", "Q55BY4", "DDB_G0271066" ] }, "reaction_10600076": { "compartment": "compartment_12045", "id": "reaction_10600076", "reactome": "R-DDI-2046085", "name": "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_211579", "species_2046056", "species_162743" ], "products": [ "species_2046064", "species_2046049", "species_2046062" ], "modifiers": [ [ "species_10600073", "catalyst" ] ], "additional_components": [ "species_29926", "Q54JK0", "DDB_G0288001", "Q55DR6", "DDB_G0269242", "Q1ZXQ4", "DDB_G0269474" ] }, "reaction_10600079": { "compartment": "compartment_17957", "id": "reaction_10600079", "reactome": "R-DDI-2046087", "name": "Translocation of tetracosahexaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046054", "species_211579" ], "products": [ "species_426639", "species_211606", "species_2046047" ], "modifiers": [ [ "species_10590195", "catalyst" ] ], "additional_components": [ "DDB_G0293194" ] }, "reaction_10578260": { "compartment": "compartment_5460", "id": "reaction_10578260", "reactome": "R-DDI-71020", "name": "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71019" ], "products": [ "species_71009" ], "modifiers": [ [ "species_10578257", "catalyst" ] ], "additional_components": [ "DDB_G0275181" ] }, "reaction_10578278": { "compartment": "compartment_5460", "id": "reaction_10578278", "reactome": "R-DDI-71031", "name": "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70843", "species_113593", "species_29376" ], "products": [ "species_113548", "species_113581", "species_71019" ], "modifiers": [ [ "species_10578275", "catalyst" ] ], "additional_components": [ "Q553S7", "DDB_G0275355", "Q8T131", "DDB_G0276341" ] }, "reaction_10582422": { "compartment": "compartment_5460", "id": "reaction_10582422", "reactome": "R-DDI-77256", "name": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77255", "species_113521" ], "products": [ "species_77252" ], "modifiers": [ [ "species_10578064", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10582424": { "compartment": "compartment_5460", "id": "reaction_10582424", "reactome": "R-DDI-77314", "name": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77313", "species_113521" ], "products": [ "species_77251" ], "modifiers": [ [ "species_10578064", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10582428": { "compartment": "compartment_5460", "id": "reaction_10582428", "reactome": "R-DDI-77333", "name": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77332", "species_113521" ], "products": [ "species_77330" ], "modifiers": [ [ "species_10578064", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10582426": { "compartment": "compartment_5460", "id": "reaction_10582426", "reactome": "R-DDI-77325", "name": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77324", "species_113521" ], "products": [ "species_77322" ], "modifiers": [ [ "species_10578064", "catalyst" ] ], "additional_components": [ "Q1ZXF1", "DDB_G0285071" ] }, "reaction_10611862": { "compartment": "compartment_5460", "id": "reaction_10611862", "reactome": "R-DDI-5696004", "name": "ACSF2 ligates CoA-SH to MCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_5690531" ], "products": [ "species_159448", "species_159450", "species_5690542" ], "modifiers": [ [ "species_10611859", "catalyst" ] ], "additional_components": [ "DDB_G0284963" ] }, "reaction_10618485": { "compartment": "compartment_70101", "id": "reaction_10618485", "reactome": "R-DDI-8848250", "name": "ACBD6 binds LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164991", "species_10618481" ], "products": [ "species_10618483" ], "modifiers": [], "additional_components": [ "DDB_G0290237", "Q54GC8", "DDB_G0290237", "species_164991" ] }, "reaction_10622907": { "compartment": "compartment_70616", "id": "reaction_10622907", "reactome": "R-DDI-8933547", "name": "MCAT transfers Mal from Mal-CoA to NDUFAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_977314", "species_10622896" ], "products": [ "species_29374", "species_10622899" ], "modifiers": [ [ "species_10622904", "catalyst" ] ], "additional_components": [ "DDB_G0291866", "DDB_G0291866", "DDB_G0270558" ] }, "reaction_10610781": { "compartment": "compartment_5460", "id": "reaction_10610781", "reactome": "R-DDI-5690066", "name": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690540", "species_113521" ], "products": [ "species_29374", "species_5690519" ], "modifiers": [ [ "species_10610778", "catalyst" ] ], "additional_components": [ "species_164991", "species_5690542", "species_174602", "species_5690531", "Q54LP9", "DDB_G0286507", "Q556W3", "DDB_G0273293" ] }, "reaction_10610767": { "compartment": "compartment_70101", "id": "reaction_10610767", "reactome": "R-DDI-5690043", "name": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5690044" ], "products": [ "species_5690064", "species_76194" ], "modifiers": [ [ "species_10610764", "catalyst" ] ], "additional_components": [ "species_5690542", "species_164991", "species_5690531", "species_174602", "C7G041", "DDB_G0295733" ] }, "reaction_10618476": { "compartment": "compartment_17957", "id": "reaction_10618476", "reactome": "R-DDI-8848246", "name": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848288", "species_10618470" ], "products": [ "species_10618474" ], "modifiers": [], "additional_components": [ "species_164991", "species_5690542", "DDB_G0270658", "Q5FXM5", "DDB_G0270658", "species_164991", "species_5690542" ] }, "reaction_10587345": { "compartment": "compartment_70101", "id": "reaction_10587345", "reactome": "R-DDI-200423", "name": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10587333" ], "products": [ "species_10587340", "species_29370" ], "modifiers": [ [ "species_10587342", "catalyst" ] ], "additional_components": [ "Q54J08", "DDB_G0288387", "species_266099", "Q54J08", "DDB_G0288387", "species_266099", "Q54YF2", "DDB_G0277905", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542" ] }, "reaction_10581624": { "compartment": "compartment_70101", "id": "reaction_10581624", "reactome": "R-DDI-75851", "name": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_113592", "species_76183" ], "products": [ "species_29372", "species_29370", "species_29508" ], "modifiers": [ [ "species_10581621", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "Q54J08", "DDB_G0288387", "species_266099" ] }, "reaction_10622445": { "compartment": "compartment_70101", "id": "reaction_10622445", "reactome": "R-DDI-8876889", "name": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_113592", "species_76183" ], "products": [ "species_29372", "species_29370", "species_29508" ], "modifiers": [ [ "species_10587333", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "Q54J08", "DDB_G0288387", "species_266099" ] }, "reaction_10612737": { "compartment": "compartment_17951", "id": "reaction_10612737", "reactome": "R-DDI-6787811", "name": "HAO2 tetramer oxidises 2OH-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_6787810" ], "products": [ "species_113575", "species_6787814" ], "modifiers": [ [ "species_10612734", "catalyst" ] ], "additional_components": [ "Q54E41", "DDB_G0291814" ] }, "reaction_10590464": { "compartment": "compartment_17951", "id": "reaction_10590464", "reactome": "R-DDI-390252", "name": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_390249" ], "products": [ "species_390248" ], "modifiers": [ [ "species_10586623", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10595810": { "compartment": "compartment_17951", "id": "reaction_10595810", "reactome": "R-DDI-977317", "name": "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_977323" ], "products": [ "species_353123", "species_389536" ], "modifiers": [ [ "species_10595807", "catalyst" ] ], "additional_components": [ "DDB_G0290089" ] }, "reaction_10590473": { "compartment": "compartment_17951", "id": "reaction_10590473", "reactome": "R-DDI-390256", "name": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_390260" ], "products": [ "species_390249", "species_113575" ], "modifiers": [ [ "species_10590470", "catalyst" ] ], "additional_components": [ "Q54GQ6", "DDB_G0289993", "species_113596" ] }, "reaction_10617416": { "compartment": "compartment_17951", "id": "reaction_10617416", "reactome": "R-DDI-6809808", "name": "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6809801" ], "products": [ "species_6809800" ], "modifiers": [ [ "species_10617413", "catalyst" ] ], "additional_components": [ "Q5FXM5", "DDB_G0270658" ] }, "reaction_10590493": { "compartment": "compartment_17947", "id": "reaction_10590493", "reactome": "R-DDI-390393", "name": "Peroxisomal uptake of very long-chain fatty acyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390394" ], "products": [ "species_390260" ], "modifiers": [ [ "species_10590197", "catalyst" ] ], "additional_components": [ "Q8T8P3", "DDB_G0293194" ] }, "reaction_10590460": { "compartment": "compartment_17951", "id": "reaction_10590460", "reactome": "R-DDI-390250", "name": "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193514", "species_390241" ], "products": [ "species_353123", "species_390246" ], "modifiers": [ [ "species_10590457", "catalyst" ] ], "additional_components": [ "DDB_G0274339" ] }, "reaction_10590462": { "compartment": "compartment_17951", "id": "reaction_10590462", "reactome": "R-DDI-390251", "name": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390248", "species_192307" ], "products": [ "species_193465", "species_390241", "species_192305" ], "modifiers": [ [ "species_10586623", "catalyst" ] ], "additional_components": [ "Q54XZ0", "DDB_G0277911" ] }, "reaction_10617487": { "compartment": "compartment_17951", "id": "reaction_10617487", "reactome": "R-DDI-6810474", "name": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_6810523" ], "products": [ "species_6809360", "species_6810530" ], "modifiers": [ [ "species_10617484", "catalyst" ] ], "additional_components": [ "DDB_G0290277" ] }, "reaction_10590323": { "compartment": "compartment_17951", "id": "reaction_10590323", "reactome": "R-DDI-389639", "name": "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389615", "species_389537" ], "products": [ "species_389594", "species_389583", "species_389536" ], "modifiers": [ [ "species_10590320", "catalyst" ] ], "additional_components": [ "species_71067", "Q54SF6", "DDB_G0282495" ] }, "reaction_10590313": { "compartment": "compartment_17951", "id": "reaction_10590313", "reactome": "R-DDI-389611", "name": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389594" ], "products": [ "species_389578", "species_389636" ], "modifiers": [ [ "species_10590310", "catalyst" ] ], "additional_components": [ "species_8878387", "species_29926", "Q54DA9", "DDB_G0292402" ] }, "reaction_10590331": { "compartment": "compartment_17947", "id": "reaction_10590331", "reactome": "R-DDI-389652", "name": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_389620" ], "products": [ "species_389573", "species_76577" ], "modifiers": [ [ "species_10590328", "catalyst" ] ], "additional_components": [ "DDB_G0272346" ] }, "reaction_10590301": { "compartment": "compartment_17951", "id": "reaction_10590301", "reactome": "R-DDI-389609", "name": "ALDH3A2-2 oxidizes pristanal to pristanate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389636", "species_192307" ], "products": [ "species_193465", "species_6811612", "species_192305" ], "modifiers": [ [ "species_10590298", "catalyst" ] ], "additional_components": [ "Q54DG1", "DDB_G0292270" ] }, "reaction_10589036": { "compartment": "compartment_70101", "id": "reaction_10589036", "reactome": "R-DDI-265296", "name": "Arachidonic acid is oxidised to 5S-HpETE by ALOX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29768" ], "products": [ "species_266010" ], "modifiers": [ [ "species_10589033", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "species_74112", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10600427": { "compartment": "compartment_70101", "id": "reaction_10600427", "reactome": "R-DDI-2161794", "name": "Arachidonic acid is converted to HXA3/B3 by ALOX12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29768" ], "products": [ "species_2162031" ], "modifiers": [ [ "species_10600421", "catalyst" ] ], "additional_components": [ "species_8942209", "CHEBI:34784", "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10600435": { "compartment": "compartment_12045", "id": "reaction_10600435", "reactome": "R-DDI-2161890", "name": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29768", "species_29364" ], "products": [ "species_29356", "species_29366", "species_2142739" ], "modifiers": [ [ "species_10582322", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10600471": { "compartment": "compartment_70101", "id": "reaction_10600471", "reactome": "R-DDI-2161961", "name": "EET(1) is hydrolysed to DHET(1) by EPHX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2161818" ], "products": [ "species_2161883" ], "modifiers": [ [ "species_10600468", "catalyst" ] ], "additional_components": [ "species_2142739", "CHEBI:34130", "CHEBI:34490", "CHEBI:34157", "CHEBI:63974", "CHEBI:63969", "CHEBI:63970", "CHEBI:63966", "Q54T91", "DDB_G0281917", "species_29926" ] }, "reaction_10600440": { "compartment": "compartment_12045", "id": "reaction_10600440", "reactome": "R-DDI-2161899", "name": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29768", "species_29364" ], "products": [ "species_29356", "species_2161753", "species_29366" ], "modifiers": [ [ "species_10600437", "catalyst" ] ], "additional_components": [ "CHEBI:34130", "CHEBI:34490", "CHEBI:34157", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10600432": { "compartment": "compartment_12045", "id": "reaction_10600432", "reactome": "R-DDI-2161814", "name": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2142836" ], "modifiers": [ [ "species_10600429", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10600447": { "compartment": "compartment_12045", "id": "reaction_10600447", "reactome": "R-DDI-2161940", "name": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2142780" ], "modifiers": [ [ "species_10588851", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10589155": { "compartment": "compartment_70101", "id": "reaction_10589155", "reactome": "R-DDI-266072", "name": "LTA4 is hydolysed to LTB4 by LTA4H", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_265281" ], "products": [ "species_266056" ], "modifiers": [ [ "species_10589152", "catalyst" ] ], "additional_components": [ "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10600500": { "compartment": "compartment_70101", "id": "reaction_10600500", "reactome": "R-DDI-2162019", "name": "LTA4 is converted to EXA4 by ALOX15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265281" ], "products": [ "species_2142772" ], "modifiers": [ [ "species_10600479", "catalyst" ] ], "additional_components": [ "species_71067", "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577" ] }, "reaction_10589113": { "compartment": "compartment_70101", "id": "reaction_10589113", "reactome": "R-DDI-266050", "name": "LTA4 is converted to LTC4 by LTC4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_265281" ], "products": [ "species_266066" ], "modifiers": [ [ "species_10589033", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "species_74112", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10589145": { "compartment": "compartment_876", "id": "reaction_10589145", "reactome": "R-DDI-266070", "name": "LTC4 is exported from the cytosol by ABCC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266066" ], "products": [ "species_266013" ], "modifiers": [ [ "species_10589142", "catalyst" ] ], "additional_components": [ "Q54JR2", "DDB_G0287691", "Q54LE6", "DDB_G0286559", "Q8ST87", "DDB_G0280977", "Q54P13", "DDB_G0284867", "Q54U44", "DDB_G0280973" ] }, "reaction_10589115": { "compartment": "compartment_70101", "id": "reaction_10589115", "reactome": "R-DDI-266051", "name": "5S-HpETE is dehydrated to LTA4 by ALOX5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266010" ], "products": [ "species_29356", "species_265281" ], "modifiers": [ [ "species_10589033", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "species_74112", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10600410": { "compartment": "compartment_70101", "id": "reaction_10600410", "reactome": "R-DDI-2161768", "name": "EXA4 is converted to EXC4 by LTC4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_2142772" ], "products": [ "species_2142726" ], "modifiers": [ [ "species_10589033", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "species_74112", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10600497": { "compartment": "compartment_70101", "id": "reaction_10600497", "reactome": "R-DDI-2162002", "name": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29768" ], "products": [ "species_2142718" ], "modifiers": [ [ "species_10600494", "catalyst" ] ], "additional_components": [ "species_71067", "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577" ] }, "reaction_10623250": { "compartment": "compartment_70101", "id": "reaction_10623250", "reactome": "R-DDI-8942208", "name": "ALOXE3 isomerises 12R-HpETE to HXA3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142790" ], "products": [ "species_8942209" ], "modifiers": [ [ "species_10623247", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577" ] }, "reaction_10600450": { "compartment": "compartment_70101", "id": "reaction_10600450", "reactome": "R-DDI-2161948", "name": "Arachidonic acid is converted to 12-oxoETE by ALOX12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29768" ], "products": [ "species_2142745" ], "modifiers": [ [ "species_10600421", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10600484": { "compartment": "compartment_70101", "id": "reaction_10600484", "reactome": "R-DDI-2161964", "name": "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29768" ], "products": [ "species_2142811" ], "modifiers": [ [ "species_10600481", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10600461": { "compartment": "compartment_70101", "id": "reaction_10600461", "reactome": "R-DDI-2161950", "name": "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29768" ], "products": [ "species_2142790" ], "modifiers": [ [ "species_10600458", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577", "species_71067" ] }, "reaction_10594017": { "compartment": "compartment_70101", "id": "reaction_10594017", "reactome": "R-DDI-549192", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_76103" ], "products": [ "species_549167", "species_76194" ], "modifiers": [ [ "species_10594014", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10611920": { "compartment": "compartment_12045", "id": "reaction_10611920", "reactome": "R-DDI-5696119", "name": "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_5696122", "species_29368" ], "products": [ "species_29356", "species_1497857", "species_76116", "species_5696116" ], "modifiers": [ [ "species_10611917", "catalyst" ] ], "additional_components": [ "DDB_G0277137" ] }, "reaction_10581764": { "compartment": "compartment_70101", "id": "reaction_10581764", "reactome": "R-DDI-75900", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_76103" ], "products": [ "species_549167", "species_76194" ], "modifiers": [ [ "species_10581761", "catalyst" ] ], "additional_components": [ "Q55BH9", "DDB_G0271342" ] }, "reaction_10581736": { "compartment": "compartment_70101", "id": "reaction_10581736", "reactome": "R-DDI-75887", "name": "Conversion of Glycerol to Glycerol-3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76116" ], "products": [ "species_29370", "species_76114" ], "modifiers": [ [ "species_10581731", "catalyst" ] ], "additional_components": [ "DDB_G0280371" ] }, "reaction_10616072": { "compartment": "compartment_12045", "id": "reaction_10616072", "reactome": "R-DDI-6800334", "name": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6800352", "species_1500578" ], "products": [ "species_76103", "species_76194" ], "modifiers": [ [ "species_10616065", "catalyst" ] ], "additional_components": [ "DDB_G0290279" ] }, "reaction_10581754": { "compartment": "compartment_70101", "id": "reaction_10581754", "reactome": "R-DDI-75899", "name": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76108", "species_29356" ], "products": [ "species_29372", "species_76103" ], "modifiers": [ [ "species_10581751", "catalyst" ] ], "additional_components": [ "Q75JA1", "DDB_G0271730" ] }, "reaction_10625442": { "compartment": "compartment_70101", "id": "reaction_10625442", "reactome": "R-DDI-9018862", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9022655" ], "products": [ "species_9022660" ], "modifiers": [ [ "species_10589152", "catalyst" ] ], "additional_components": [ "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10625439": { "compartment": "compartment_70101", "id": "reaction_10625439", "reactome": "R-DDI-9018859", "name": "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9020602" ], "products": [ "species_9022655" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625485": { "compartment": "compartment_70101", "id": "reaction_10625485", "reactome": "R-DDI-9020610", "name": "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9020474" ], "products": [ "species_9022679" ], "modifiers": [ [ "species_10600477", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577" ] }, "reaction_10625437": { "compartment": "compartment_70101", "id": "reaction_10625437", "reactome": "R-DDI-9018858", "name": "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9020474" ], "products": [ "species_9020602" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625446": { "compartment": "compartment_70101", "id": "reaction_10625446", "reactome": "R-DDI-9018877", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9023708" ], "products": [ "species_9023712" ], "modifiers": [ [ "species_10589152", "catalyst" ] ], "additional_components": [ "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10625444": { "compartment": "compartment_70101", "id": "reaction_10625444", "reactome": "R-DDI-9018863", "name": "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023651", "species_29368" ], "products": [ "species_9023702" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625451": { "compartment": "compartment_70101", "id": "reaction_10625451", "reactome": "R-DDI-9018907", "name": "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023651", "species_29368" ], "products": [ "species_9023644" ], "modifiers": [ [ "species_10600477", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577" ] }, "reaction_10625448": { "compartment": "compartment_70101", "id": "reaction_10625448", "reactome": "R-DDI-9018894", "name": "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023702", "species_29368" ], "products": [ "species_9023708" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625505": { "compartment": "compartment_70101", "id": "reaction_10625505", "reactome": "R-DDI-9025957", "name": "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9025155", "species_29368" ], "products": [ "species_9025960" ], "modifiers": [ [ "species_10600421", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10625503": { "compartment": "compartment_70101", "id": "reaction_10625503", "reactome": "R-DDI-9025152", "name": "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9025155", "species_29368" ], "products": [ "species_9025151" ], "modifiers": [ [ "species_10600477", "catalyst" ] ], "additional_components": [ "CHEBI:138674", "CHEBI:138673", "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577" ] }, "reaction_10625507": { "compartment": "compartment_70101", "id": "reaction_10625507", "reactome": "R-DDI-9025995", "name": "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9026034", "species_29366" ], "products": [ "species_9026050", "species_29364" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625511": { "compartment": "compartment_70101", "id": "reaction_10625511", "reactome": "R-DDI-9025999", "name": "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9026047" ], "products": [ "species_9026046", "species_29364" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625509": { "compartment": "compartment_70101", "id": "reaction_10625509", "reactome": "R-DDI-9025996", "name": "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9026047" ], "products": [ "species_9026034" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625513": { "compartment": "compartment_70101", "id": "reaction_10625513", "reactome": "R-DDI-9026003", "name": "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9608444", "species_29368" ], "products": [ "species_9026047" ], "modifiers": [ [ "species_10600477", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577" ] }, "reaction_10625521": { "compartment": "compartment_70101", "id": "reaction_10625521", "reactome": "R-DDI-9026405", "name": "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9026400", "species_29368" ], "products": [ "species_9026394" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "CHEBI:137020", "CHEBI:137011", "CHEBI:137018", "CHEBI:137019", "DDB_G0279909" ] }, "reaction_10625547": { "compartment": "compartment_70101", "id": "reaction_10625547", "reactome": "R-DDI-9027628", "name": "ALOX5 oxidises EPA to 5-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2026977", "species_29368" ], "products": [ "species_9028283" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625545": { "compartment": "compartment_70101", "id": "reaction_10625545", "reactome": "R-DDI-9027624", "name": "ALOX5 oxidises DHA to 7-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024011" ], "products": [ "species_9028274" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625549": { "compartment": "compartment_70101", "id": "reaction_10625549", "reactome": "R-DDI-9027633", "name": "ALOX5 oxidises DPAn-3 to 7-HDPAn-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9608444", "species_29368" ], "products": [ "species_9028240" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10600424": { "compartment": "compartment_70101", "id": "reaction_10600424", "reactome": "R-DDI-2161775", "name": "ALOX12 oxidises LTA4 to LXA4/B4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9032038", "species_29368" ], "products": [ "species_2161856" ], "modifiers": [ [ "species_10600421", "catalyst" ] ], "additional_components": [ "CHEBI:6499", "CHEBI:6498", "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10600443": { "compartment": "compartment_70101", "id": "reaction_10600443", "reactome": "R-DDI-2161907", "name": "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_2142738" ], "products": [ "species_2161609" ], "modifiers": [ [ "species_10589033", "catalyst" ] ], "additional_components": [ "CHEBI:63991", "CHEBI:63990", "Q54W35", "DDB_G0279909", "species_74112", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10600445": { "compartment": "compartment_70101", "id": "reaction_10600445", "reactome": "R-DDI-2161917", "name": "ALOX5 oxidises 15S-HpETE to LXA4/B4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142718", "species_29368" ], "products": [ "species_2161856" ], "modifiers": [ [ "species_10589033", "catalyst" ] ], "additional_components": [ "CHEBI:6499", "CHEBI:6498", "Q54W35", "DDB_G0279909", "species_74112", "species_71067", "Q54GA9", "DDB_G0290291" ] }, "reaction_10625475": { "compartment": "compartment_70101", "id": "reaction_10625475", "reactome": "R-DDI-9020274", "name": "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024011" ], "products": [ "species_9025012" ], "modifiers": [ [ "species_10600421", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10625473": { "compartment": "compartment_70101", "id": "reaction_10625473", "reactome": "R-DDI-9020270", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024577" ], "products": [ "species_9024570" ], "modifiers": [ [ "species_10589152", "catalyst" ] ], "additional_components": [ "CHEBI:138615", "CHEBI:138616", "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10625461": { "compartment": "compartment_70101", "id": "reaction_10625461", "reactome": "R-DDI-9020256", "name": "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024479" ], "products": [ "species_29364", "species_9024602" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625467": { "compartment": "compartment_70101", "id": "reaction_10625467", "reactome": "R-DDI-9020259", "name": "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024463" ], "products": [ "species_9024576" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625481": { "compartment": "compartment_70101", "id": "reaction_10625481", "reactome": "R-DDI-9020278", "name": "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024576", "species_29366" ], "products": [ "species_9024577", "species_29364" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625455": { "compartment": "compartment_70101", "id": "reaction_10625455", "reactome": "R-DDI-9020252", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024602" ], "products": [ "species_9024574" ], "modifiers": [ [ "species_10589152", "catalyst" ] ], "additional_components": [ "CHEBI:138179", "CHEBI:138614", "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10625453": { "compartment": "compartment_70101", "id": "reaction_10625453", "reactome": "R-DDI-9020251", "name": "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024463" ], "products": [ "species_9024479" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625477": { "compartment": "compartment_70101", "id": "reaction_10625477", "reactome": "R-DDI-9020275", "name": "ALOX15 oxidises DHA to 17(S)-Hp-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024011" ], "products": [ "species_9024012" ], "modifiers": [ [ "species_10600477", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577" ] }, "reaction_10625493": { "compartment": "compartment_70101", "id": "reaction_10625493", "reactome": "R-DDI-9024881", "name": "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024012" ], "products": [ "species_29364", "species_9024873" ], "modifiers": [ [ "species_10600477", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577" ] }, "reaction_10625459": { "compartment": "compartment_70101", "id": "reaction_10625459", "reactome": "R-DDI-9020255", "name": "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024765" ], "products": [ "species_9024768", "species_29364" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625457": { "compartment": "compartment_70101", "id": "reaction_10625457", "reactome": "R-DDI-9020253", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024781" ], "products": [ "species_9024809" ], "modifiers": [ [ "species_10589152", "catalyst" ] ], "additional_components": [ "CHEBI:138649", "CHEBI:138648", "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10625479": { "compartment": "compartment_70101", "id": "reaction_10625479", "reactome": "R-DDI-9020277", "name": "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024797" ], "products": [ "species_29364", "species_9024781" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625483": { "compartment": "compartment_70101", "id": "reaction_10625483", "reactome": "R-DDI-9020282", "name": "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024815" ], "products": [ "species_9024765" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625465": { "compartment": "compartment_70101", "id": "reaction_10625465", "reactome": "R-DDI-9020258", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024768" ], "products": [ "species_9024759" ], "modifiers": [ [ "species_10589152", "catalyst" ] ], "additional_components": [ "CHEBI:81565", "CHEBI:81564", "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10625471": { "compartment": "compartment_70101", "id": "reaction_10625471", "reactome": "R-DDI-9020264", "name": "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024815" ], "products": [ "species_9024797" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625497": { "compartment": "compartment_70101", "id": "reaction_10625497", "reactome": "R-DDI-9024983", "name": "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9025012", "species_29366" ], "products": [ "species_29364", "species_9025001" ], "modifiers": [ [ "species_10600421", "catalyst" ] ], "additional_components": [ "Q86H96", "DDB_G0275577", "Q54W35", "DDB_G0279909", "species_71067" ] }, "reaction_10625538": { "compartment": "compartment_70101", "id": "reaction_10625538", "reactome": "R-DDI-9027043", "name": "CYPs hydroxylate DHA to 14(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_9024011" ], "products": [ "species_29356", "species_29366", "species_9027049" ], "modifiers": [ [ "species_10625535", "catalyst" ] ], "additional_components": [ "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778" ] }, "reaction_10625543": { "compartment": "compartment_70101", "id": "reaction_10625543", "reactome": "R-DDI-9027321", "name": "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_9027049" ], "products": [ "species_29356", "species_29366", "species_9027324" ], "modifiers": [ [ "species_10582018", "catalyst" ] ], "additional_components": [ "CHEBI:137368", "CHEBI:137361", "Q1ZXF5", "DDB_G0284535", "Q86A22", "DDB_G0272704", "Q54SK0", "DDB_G0282419", "Q54LA8", "DDB_G0286743", "Q54SV9", "DDB_G0282283", "Q1ZXG3", "DDB_G0282769", "Q54LT7", "DDB_G0286419", "Q1ZXL2", "DDB_G0275197", "Q54ZM4", "DDB_G0277545", "Q54NY3", "DDB_G0284923", "Q556M4", "DDB_G0272604", "Q1ZXL7", "DDB_G0273047", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54CS3", "DDB_G0292792", "Q1ZXA4", "DDB_G0292790", "Q556M5", "DDB_G0273045", "Q54QD0", "DDB_G0283933", "Q55AJ4", "DDB_G0271778", "Q54DT2", "DDB_G0292168", "Q54QD2", "DDB_G0283929", "Q1ZXF3", "DDB_G0284647", "Q54EM5", "DDB_G0291448" ] }, "reaction_10625541": { "compartment": "compartment_70101", "id": "reaction_10625541", "reactome": "R-DDI-9027302", "name": "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9027029", "species_70106", "species_29368", "species_29364" ], "products": [ "species_29356", "species_9027326", "species_29366" ], "modifiers": [ [ "species_10582018", "catalyst" ] ], "additional_components": [ "CHEBI:137360", "CHEBI:137354", "Q1ZXF5", "DDB_G0284535", "Q86A22", "DDB_G0272704", "Q54SK0", "DDB_G0282419", "Q54LA8", "DDB_G0286743", "Q54SV9", "DDB_G0282283", "Q1ZXG3", "DDB_G0282769", "Q54LT7", "DDB_G0286419", "Q1ZXL2", "DDB_G0275197", "Q54ZM4", "DDB_G0277545", "Q54NY3", "DDB_G0284923", "Q556M4", "DDB_G0272604", "Q1ZXL7", "DDB_G0273047", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54CS3", "DDB_G0292792", "Q1ZXA4", "DDB_G0292790", "Q556M5", "DDB_G0273045", "Q54QD0", "DDB_G0283933", "Q55AJ4", "DDB_G0271778", "Q54DT2", "DDB_G0292168", "Q54QD2", "DDB_G0283929", "Q1ZXF3", "DDB_G0284647", "Q54EM5", "DDB_G0291448" ] }, "reaction_10625499": { "compartment": "compartment_70101", "id": "reaction_10625499", "reactome": "R-DDI-9024993", "name": "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_9025001" ], "products": [ "species_9025011" ], "modifiers": [ [ "species_10600468", "catalyst" ] ], "additional_components": [ "Q54T91", "DDB_G0281917", "species_29926" ] }, "reaction_10625501": { "compartment": "compartment_70101", "id": "reaction_10625501", "reactome": "R-DDI-9024997", "name": "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9025012", "species_29368" ], "products": [ "species_9024989" ], "modifiers": [ [ "species_10591746", "catalyst" ] ], "additional_components": [ "DDB_G0279909" ] }, "reaction_10625533": { "compartment": "compartment_70101", "id": "reaction_10625533", "reactome": "R-DDI-9026911", "name": "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9024768" ], "products": [ "species_9026915" ], "modifiers": [ [ "species_10625528", "catalyst" ] ], "additional_components": [ "Q54GA9", "DDB_G0290291" ] }, "reaction_10625524": { "compartment": "compartment_70101", "id": "reaction_10625524", "reactome": "R-DDI-9026777", "name": "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9025001" ], "products": [ "species_9026761" ], "modifiers": [ [ "species_10585637", "catalyst" ] ], "additional_components": [ "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q54VI4", "DDB_G0280317", "Q556G3", "DDB_G0272632", "Q556P3", "DDB_G0273153", "Q55FF3", "DDB_G0268138" ] }, "reaction_10625531": { "compartment": "compartment_70101", "id": "reaction_10625531", "reactome": "R-DDI-9026780", "name": "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9025001" ], "products": [ "species_9026761" ], "modifiers": [ [ "species_10625528", "catalyst" ] ], "additional_components": [ "Q54GA9", "DDB_G0290291" ] }, "reaction_10625491": { "compartment": "compartment_70101", "id": "reaction_10625491", "reactome": "R-DDI-9024872", "name": "ALOX15 oxidises 17(S)-Hp-DHA to PDX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_9024012" ], "products": [ "species_9024883" ], "modifiers": [ [ "species_10600477", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577" ] }, "reaction_10625495": { "compartment": "compartment_70101", "id": "reaction_10625495", "reactome": "R-DDI-9024890", "name": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024873" ], "products": [ "species_9024886" ], "modifiers": [ [ "species_10589152", "catalyst" ] ], "additional_components": [ "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10625463": { "compartment": "compartment_70101", "id": "reaction_10625463", "reactome": "R-DDI-9020257", "name": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024893" ], "products": [ "species_9024879" ], "modifiers": [ [ "species_10589152", "catalyst" ] ], "additional_components": [ "species_29426", "P52922", "DDB_G0269148" ] }, "reaction_10625469": { "compartment": "compartment_70101", "id": "reaction_10625469", "reactome": "R-DDI-9020262", "name": "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_9024522" ], "products": [ "species_29364", "species_9024893" ], "modifiers": [ [ "species_10600477", "catalyst" ] ], "additional_components": [ "Q54W35", "DDB_G0279909", "Q86H96", "DDB_G0275577" ] }, "reaction_10591619": { "compartment": "compartment_70101", "id": "reaction_10591619", "reactome": "R-DDI-428214", "name": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428163" ], "products": [ "species_29370", "species_428275" ], "modifiers": [ [ "species_10591616", "catalyst" ] ], "additional_components": [ "Q6B516", "DDB_G0284545", "Q54HN2", "DDB_G0289343", "Q86KF9", "DDB_G0272522" ] }, "reaction_10591683": { "compartment": "compartment_70101", "id": "reaction_10591683", "reactome": "R-DDI-428676", "name": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203" ], "products": [ "species_428671", "species_428686" ], "modifiers": [ [ "species_10591680", "catalyst" ] ], "additional_components": [ "DDB_G0282819" ] }, "reaction_10611267": { "compartment": "compartment_12045", "id": "reaction_10611267", "reactome": "R-DDI-5692261", "name": "ALDH3A2-1 oxidises HD2NAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428671", "species_29360" ], "products": [ "species_70106", "species_3632881", "species_73473" ], "modifiers": [ [ "species_10611264", "catalyst" ] ], "additional_components": [ "Q54DG1", "DDB_G0292270" ] }, "reaction_10591685": { "compartment": "compartment_70101", "id": "reaction_10591685", "reactome": "R-DDI-428681", "name": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428275" ], "products": [ "species_428686", "species_428663" ], "modifiers": [ [ "species_10591680", "catalyst" ] ], "additional_components": [ "DDB_G0282819" ] }, "reaction_10624103": { "compartment": "compartment_12045", "id": "reaction_10624103", "reactome": "R-DDI-8959462", "name": "SAMD8 transforms PE and CERA to CPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8959490", "species_8959486" ], "products": [ "species_8959463" ], "modifiers": [ [ "species_10624100", "catalyst" ] ], "additional_components": [ "DDB_G0293880" ] }, "reaction_10591627": { "compartment": "compartment_70101", "id": "reaction_10591627", "reactome": "R-DDI-428259", "name": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_428206", "species_428126", "species_29368" ], "products": [ "species_428218", "species_29356", "species_428256" ], "modifiers": [ [ "species_10591624", "catalyst" ] ], "additional_components": [ "species_192305", "species_29364", "species_29360", "species_29366", "DDB_G0269738" ] }, "reaction_10591819": { "compartment": "compartment_876", "id": "reaction_10591819", "reactome": "R-DDI-429786", "name": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429802", "species_429807" ], "products": [ "species_429776", "species_112275" ], "modifiers": [ [ "species_10591816", "catalyst" ] ], "additional_components": [ "DDB_G0293880" ] }, "reaction_10611887": { "compartment": "compartment_876", "id": "reaction_10611887", "reactome": "R-DDI-5696080", "name": "ALDH3B1 oxidises HXAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428663", "species_29360" ], "products": [ "species_70106", "species_3632881", "species_73473" ], "modifiers": [ [ "species_10611884", "catalyst" ] ], "additional_components": [ "DDB_G0292270" ] }, "reaction_10591630": { "compartment": "compartment_70101", "id": "reaction_10591630", "reactome": "R-DDI-428260", "name": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_428126", "species_29368", "species_29364" ], "products": [ "species_29356", "species_29366", "species_9025544" ], "modifiers": [ [ "species_10591624", "catalyst" ] ], "additional_components": [ "DDB_G0269738" ] }, "reaction_10591726": { "compartment": "compartment_70101", "id": "reaction_10591726", "reactome": "R-DDI-428696", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203", "species_29356" ], "products": [ "species_428682", "species_29372" ], "modifiers": [ [ "species_10591723", "catalyst" ] ], "additional_components": [ "Q54PR7", "DDB_G0284367", "Q86AF0", "DDB_G0284367", "Q8MXL9", "DDB_G0284367" ] }, "reaction_10591729": { "compartment": "compartment_70101", "id": "reaction_10591729", "reactome": "R-DDI-428701", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203", "species_29356" ], "products": [ "species_428682", "species_29372" ], "modifiers": [ [ "species_10591669", "catalyst" ] ], "additional_components": [ "DDB_G0272260" ] }, "reaction_10591824": { "compartment": "compartment_20699", "id": "reaction_10591824", "reactome": "R-DDI-429798", "name": "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429785", "species_428270" ], "products": [ "species_429773", "species_429789" ], "modifiers": [ [ "species_10591821", "catalyst" ] ], "additional_components": [ "DDB_G0293880" ] }, "reaction_10591600": { "compartment": "compartment_70101", "id": "reaction_10591600", "reactome": "R-DDI-428185", "name": "sphinganine + stearyl-CoA => dihydroceramide + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428139", "species_428163" ], "products": [ "species_428126", "species_76194" ], "modifiers": [ [ "species_10591587", "catalyst" ] ], "additional_components": [ "DDB_G0282607" ] }, "reaction_10616950": { "compartment": "compartment_13977", "id": "reaction_10616950", "reactome": "R-DDI-6808464", "name": "ALDH3B2 oxidises HXAL to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6808468", "species_29360" ], "products": [ "species_2453691", "species_70106", "species_73473" ], "modifiers": [ [ "species_10616947", "catalyst" ] ], "additional_components": [ "DDB_G0292270" ] }, "reaction_10591638": { "compartment": "compartment_70101", "id": "reaction_10591638", "reactome": "R-DDI-428262", "name": "phytoceramide + H2O => stearate + phytosphingosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9025544" ], "products": [ "species_428237", "species_3632878" ], "modifiers": [ [ "species_10591635", "catalyst" ] ], "additional_components": [ "DDB_G0288359" ] }, "reaction_10591641": { "compartment": "compartment_70101", "id": "reaction_10591641", "reactome": "R-DDI-428273", "name": "SPHK1 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428193" ], "products": [ "species_428203", "species_29370" ], "modifiers": [ [ "species_10590508", "catalyst" ] ], "additional_components": [ "DDB_G0284545" ] }, "reaction_10591705": { "compartment": "compartment_984", "id": "reaction_10591705", "reactome": "R-DDI-428690", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_419305", "species_109276" ], "products": [ "species_109277", "species_428662" ], "modifiers": [ [ "species_10591702", "catalyst" ] ], "additional_components": [ "Q8MXL9", "DDB_G0284367", "Q54PR7", "DDB_G0284367", "Q86AF0", "DDB_G0284367" ] }, "reaction_10591674": { "compartment": "compartment_70101", "id": "reaction_10591674", "reactome": "R-DDI-428664", "name": "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428275" ], "products": [ "species_29372", "species_428694" ], "modifiers": [ [ "species_10591669", "catalyst" ] ], "additional_components": [ "DDB_G0272260" ] }, "reaction_10611452": { "compartment": "compartment_12045", "id": "reaction_10611452", "reactome": "R-DDI-5693761", "name": "FA2H hydroxylates CERA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_428256" ], "products": [ "species_5693768", "species_29356" ], "modifiers": [ [ "species_10611449", "catalyst" ] ], "additional_components": [ "DDB_G0269908" ] }, "reaction_10627391": { "compartment": "compartment_70101", "id": "reaction_10627391", "reactome": "R-DDI-9695949", "name": "SPHK2 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428193" ], "products": [ "species_428203", "species_29370" ], "modifiers": [ [ "species_10591614", "catalyst" ], [ "species_10627389", "inhibitor" ] ], "additional_components": [ "Q54HN2", "DDB_G0289343", "Q6B516", "DDB_G0284545", "Q86KF9", "DDB_G0272522", "Q54HN2", "DDB_G0289343", "Q6B516", "DDB_G0284545", "Q86KF9", "DDB_G0272522" ] }, "reaction_10591582": { "compartment": "compartment_70101", "id": "reaction_10591582", "reactome": "R-DDI-428123", "name": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_428182" ], "products": [ "species_29366", "species_428163" ], "modifiers": [ [ "species_10591579", "catalyst" ] ], "additional_components": [ "DDB_G0289061" ] }, "reaction_10586816": { "compartment": "compartment_70101", "id": "reaction_10586816", "reactome": "R-DDI-196761", "name": "2xTPK1:Mg2+ phosphorylates THMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196934" ], "products": [ "species_29480", "species_76577" ], "modifiers": [ [ "species_10586813", "catalyst" ] ], "additional_components": [ "species_29926", "Q55GR8", "DDB_G0267546" ] }, "reaction_10587239": { "compartment": "compartment_876", "id": "reaction_10587239", "reactome": "R-DDI-199626", "name": "SLC19A2/3 transport extracellular THMN to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199622" ], "products": [ "species_196934" ], "modifiers": [ [ "species_10587236", "catalyst" ] ], "additional_components": [ "Q559K0", "DDB_G0272544" ] }, "reaction_10622123": { "compartment": "compartment_17927", "id": "reaction_10622123", "reactome": "R-DDI-8875838", "name": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29480" ], "products": [ "species_8878387" ], "modifiers": [ [ "species_10622120", "catalyst" ] ], "additional_components": [ "DDB_G0280161" ] }, "reaction_10587154": { "compartment": "compartment_876", "id": "reaction_10587154", "reactome": "R-DDI-198818", "name": "SLC2A1,3 transports DeHA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198852" ], "products": [ "species_198827" ], "modifiers": [ [ "species_10587151", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10587173": { "compartment": "compartment_70101", "id": "reaction_10587173", "reactome": "R-DDI-198845", "name": "CYB5A:heme reduces Asc.- to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1497805", "species_10587170" ], "products": [ "species_198816", "species_10587168" ], "modifiers": [ [ "species_10587170", "catalyst" ] ], "additional_components": [ "species_917877", "Q54XT7", "DDB_G0278753", "Q86L22", "DDB_G0277079", "CHEBI:36144", "Q54XT7", "DDB_G0278753", "Q86L22", "DDB_G0277079", "species_917877", "Q54XT7", "DDB_G0278753", "Q86L22", "DDB_G0277079" ] }, "reaction_10587189": { "compartment": "compartment_70101", "id": "reaction_10587189", "reactome": "R-DDI-199202", "name": "Phosphopantetheine conjugation of the ACP domain of FAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587181", "species_76194" ], "products": [ "species_10581670", "species_158466" ], "modifiers": [ [ "species_10587186", "catalyst" ] ], "additional_components": [ "Q55E72", "DDB_G0269364", "Q869W9", "DDB_G0275069", "Q869X2", "DDB_G0275077", "Q869X2", "DDB_G0275077", "Q55E72", "DDB_G0269364", "Q869W9", "DDB_G0275069", "DDB_G0285927" ] }, "reaction_10623045": { "compartment": "compartment_70101", "id": "reaction_10623045", "reactome": "R-DDI-8938300", "name": "Vanin hydrolyses pantetheine to PanK, 2AET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8938313" ], "products": [ "species_196820", "species_6814151" ], "modifiers": [ [ "species_10623042", "catalyst" ] ], "additional_components": [ "Q54WG1", "DDB_G0279675" ] }, "reaction_10586819": { "compartment": "compartment_70101", "id": "reaction_10586819", "reactome": "R-DDI-196773", "name": "COASY phosphorylates DP-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196778" ], "products": [ "species_29370", "species_76194" ], "modifiers": [ [ "species_10586803", "catalyst" ] ], "additional_components": [ "DDB_G0288465" ] }, "reaction_10586806": { "compartment": "compartment_70101", "id": "reaction_10586806", "reactome": "R-DDI-196754", "name": "COASY transfers an adenylyl group from ATP to PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196767", "species_113592" ], "products": [ "species_111294", "species_196778" ], "modifiers": [ [ "species_10586803", "catalyst" ] ], "additional_components": [ "DDB_G0288465" ] }, "reaction_10586829": { "compartment": "compartment_70101", "id": "reaction_10586829", "reactome": "R-DDI-196840", "name": "3xPPCDC:3FMN decarboxylates PPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196834" ], "products": [ "species_196767", "species_113528" ], "modifiers": [ [ "species_10586826", "catalyst" ] ], "additional_components": [ "species_76629", "Q54Y51", "DDB_G0278413" ] }, "reaction_10587197": { "compartment": "compartment_70616", "id": "reaction_10587197", "reactome": "R-DDI-199216", "name": "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76194" ], "products": [ "species_29374" ], "modifiers": [ [ "species_10587194", "catalyst" ] ], "additional_components": [ "DDB_G0292034" ] }, "reaction_10586798": { "compartment": "compartment_70101", "id": "reaction_10586798", "reactome": "R-DDI-196753", "name": "2xPPCS ligates PPanK with Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_113592", "species_196786" ], "products": [ "species_111294", "species_196834", "species_76577" ], "modifiers": [ [ "species_10586795", "catalyst" ] ], "additional_components": [ "Q54S85", "DDB_G0282611" ] }, "reaction_10595303": { "compartment": "compartment_70101", "id": "reaction_10595303", "reactome": "R-DDI-947499", "name": "Exchange of oxygen with sulfur in MoCo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_947539", "species_111707" ], "products": [ "species_947575", "species_29432" ], "modifiers": [ [ "species_10595300", "catalyst" ] ], "additional_components": [ "DDB_G0272935" ] }, "reaction_10595350": { "compartment": "compartment_70101", "id": "reaction_10595350", "reactome": "R-DDI-947535", "name": "Cyclisation of GTP to precursor Z", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29356", "species_71284" ], "products": [ "species_111294", "species_947537", "species_947703", "species_174390" ], "modifiers": [ [ "species_10595347", "catalyst" ] ], "additional_components": [ "Q54NM6", "DDB_G0285137", "CHEBI:33722" ] }, "reaction_10595338": { "compartment": "compartment_70101", "id": "reaction_10595338", "reactome": "R-DDI-947531", "name": "Molybdenum ion transfer onto molybdopterin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_947561", "species_947496" ], "products": [ "species_111294", "species_947539", "species_76577" ], "modifiers": [ [ "species_10595335", "catalyst" ] ], "additional_components": [ "Q54KM0", "DDB_G0287261", "species_29926" ] }, "reaction_10595326": { "compartment": "compartment_70101", "id": "reaction_10595326", "reactome": "R-DDI-947514", "name": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10595310", "species_111707" ], "products": [ "species_29432", "species_10595315" ], "modifiers": [ [ "species_10595323", "catalyst" ] ], "additional_components": [ "species_29426", "Q55FS0", "DDB_G0267980", "Q55FS0", "DDB_G0267980", "species_29426", "Q54X04", "DDB_G0279287" ] }, "reaction_10595424": { "compartment": "compartment_70101", "id": "reaction_10595424", "reactome": "R-DDI-964970", "name": "2xPDXK:2xZn2+ phosphorylates PXL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_965131" ], "products": [ "species_29390", "species_29370" ], "modifiers": [ [ "species_10595417", "catalyst" ] ], "additional_components": [ "species_29426", "Q55EK9", "DDB_G0268628" ] }, "reaction_10602082": { "compartment": "compartment_70101", "id": "reaction_10602082", "reactome": "R-DDI-3204311", "name": "AOX1 oxidises PXL to PDXate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29368", "species_965131" ], "products": [ "species_3204324", "species_29408" ], "modifiers": [ [ "species_10602079", "catalyst" ] ], "additional_components": [ "CHEBI:33722", "CHEBI:44074", "species_113596", "Q54FB7", "DDB_G0291047" ] }, "reaction_10595434": { "compartment": "compartment_70101", "id": "reaction_10595434", "reactome": "R-DDI-965019", "name": "2xPNPO:2xFMN oxidizes PDXP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_964952" ], "products": [ "species_29390", "species_29408" ], "modifiers": [ [ "species_10595431", "catalyst" ] ], "additional_components": [ "Q54YS6", "DDB_G0278107", "species_76629" ] }, "reaction_10595420": { "compartment": "compartment_70101", "id": "reaction_10595420", "reactome": "R-DDI-964958", "name": "2xPDXK:2xZn2+ phosphorylates PXA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964945", "species_113592" ], "products": [ "species_29370", "species_965146" ], "modifiers": [ [ "species_10595417", "catalyst" ] ], "additional_components": [ "species_29426", "Q55EK9", "DDB_G0268628" ] }, "reaction_10595436": { "compartment": "compartment_70101", "id": "reaction_10595436", "reactome": "R-DDI-965079", "name": "2xPNPO:2xFMN oxidizes PXAP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29368", "species_965146" ], "products": [ "species_29390", "species_31633", "species_29408" ], "modifiers": [ [ "species_10595431", "catalyst" ] ], "additional_components": [ "Q54YS6", "DDB_G0278107", "species_76629" ] }, "reaction_10595422": { "compartment": "compartment_70101", "id": "reaction_10595422", "reactome": "R-DDI-964962", "name": "2xPDKX:2xZn2+ phosphorylates PDX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_965053" ], "products": [ "species_29370", "species_964952" ], "modifiers": [ [ "species_10595417", "catalyst" ] ], "additional_components": [ "species_29426", "Q55EK9", "DDB_G0268628" ] }, "reaction_10603568": { "compartment": "compartment_5460", "id": "reaction_10603568", "reactome": "R-DDI-4167509", "name": "Mitochondrial BTD hydrolyses BCTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3065953" ], "products": [ "species_29582", "species_29444" ], "modifiers": [ [ "species_10603565", "catalyst" ] ], "additional_components": [ "DDB_G0279675" ] }, "reaction_10603574": { "compartment": "compartment_70101", "id": "reaction_10603574", "reactome": "R-DDI-4167511", "name": "HLCS biotinylates ACACB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10603572", "species_199207" ], "products": [ "species_111294", "species_10587331", "species_76577" ], "modifiers": [ [ "species_10601704", "catalyst" ] ], "additional_components": [ "Q54J08", "DDB_G0288387", "species_266099", "Q54J08", "DDB_G0288387", "species_266099", "DDB_G0288791" ] }, "reaction_10601752": { "compartment": "compartment_70101", "id": "reaction_10601752", "reactome": "R-DDI-2993814", "name": "HLCS biotinylates ACACA:Mn2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10601750", "species_199207" ], "products": [ "species_111294", "species_10581619", "species_76577" ], "modifiers": [ [ "species_10601704", "catalyst" ] ], "additional_components": [ "Q54J08", "DDB_G0288387", "species_266099", "Q54J08", "DDB_G0288387", "species_266099", "DDB_G0288791" ] }, "reaction_10601707": { "compartment": "compartment_70101", "id": "reaction_10601707", "reactome": "R-DDI-2993447", "name": "HLCS biotinylates 6x(PCCA:PCCB)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601693", "species_113592", "species_199207" ], "products": [ "species_111294", "species_10601699", "species_76577" ], "modifiers": [ [ "species_10601704", "catalyst" ] ], "additional_components": [ "Q8T131", "DDB_G0276341", "Q553S7", "DDB_G0275355", "Q8T131", "DDB_G0276341", "Q553S7", "DDB_G0275355", "DDB_G0288791" ] }, "reaction_10602666": { "compartment": "compartment_70101", "id": "reaction_10602666", "reactome": "R-DDI-3323111", "name": "Cytoslic carboxylases translocate to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601699" ], "products": [ "species_10578275" ], "modifiers": [], "additional_components": [ "Q8T131", "DDB_G0276341", "Q553S7", "DDB_G0275355", "Q553S7", "DDB_G0275355", "Q8T131", "DDB_G0276341" ] }, "reaction_10601951": { "compartment": "compartment_984", "id": "reaction_10601951", "reactome": "R-DDI-3076905", "name": "Extracellular BTD hydrolyses BCTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3076887" ], "products": [ "species_199238", "species_351991" ], "modifiers": [ [ "species_10601948", "catalyst" ] ], "additional_components": [ "DDB_G0279675" ] }, "reaction_10586913": { "compartment": "compartment_70101", "id": "reaction_10586913", "reactome": "R-DDI-197972", "name": "DHF is reduced to tetrahydrofolate (THF)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73604", "species_29364" ], "products": [ "species_111355", "species_29366" ], "modifiers": [ [ "species_10586908", "catalyst" ] ], "additional_components": [ "DDB_G0286755" ] }, "reaction_10616513": { "compartment": "compartment_5460", "id": "reaction_10616513", "reactome": "R-DDI-6801456", "name": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113581", "species_5389850" ], "products": [ "species_200671", "species_6801451", "species_113593" ], "modifiers": [ [ "species_10612187", "catalyst" ] ], "additional_components": [ "Q54RI8", "DDB_G0283121", "Q54VK0", "DDB_G0283121" ] }, "reaction_10616966": { "compartment": "compartment_5460", "id": "reaction_10616966", "reactome": "R-DDI-6808487", "name": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_6808499", "species_113521" ], "products": [ "species_113529", "species_200679", "species_113600", "species_29376" ], "modifiers": [ [ "species_10616963", "catalyst" ] ], "additional_components": [ "Q54FY1", "DDB_G0290537", "Q54FY3", "DDB_G0290479", "Q54FY2", "DDB_G0290537" ] }, "reaction_10616516": { "compartment": "compartment_5460", "id": "reaction_10616516", "reactome": "R-DDI-6801462", "name": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6801458", "species_113521" ], "products": [ "species_5389850" ], "modifiers": [ [ "species_10616508", "catalyst" ] ], "additional_components": [ "Q54RI8", "DDB_G0283121", "Q54VK0", "DDB_G0283121" ] }, "reaction_10587398": { "compartment": "compartment_70616", "id": "reaction_10587398", "reactome": "R-DDI-200680", "name": "SLC25A32 transports THF from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111355" ], "products": [ "species_200671" ], "modifiers": [ [ "species_10587395", "catalyst" ] ], "additional_components": [ "DDB_G0271922" ] }, "reaction_10587400": { "compartment": "compartment_70101", "id": "reaction_10587400", "reactome": "R-DDI-200681", "name": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_200665", "species_113592" ], "products": [ "species_29372", "species_29370", "species_174404" ], "modifiers": [ [ "species_10586900", "catalyst" ] ], "additional_components": [ "DDB_G0292632" ] }, "reaction_10587405": { "compartment": "compartment_5460", "id": "reaction_10587405", "reactome": "R-DDI-200682", "name": "Mitochondrial FPGS-1 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200671", "species_113593", "species_113552" ], "products": [ "species_113548", "species_113581", "species_200679" ], "modifiers": [ [ "species_10587402", "catalyst" ] ], "additional_components": [ "DDB_G0292632" ] }, "reaction_10587372": { "compartment": "compartment_70101", "id": "reaction_10587372", "reactome": "R-DDI-200644", "name": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_200739" ], "products": [ "species_70106", "species_29364", "species_200640" ], "modifiers": [ [ "species_10587369", "catalyst" ] ], "additional_components": [ "Q54RI8", "DDB_G0283121" ] }, "reaction_10587377": { "compartment": "compartment_876", "id": "reaction_10587377", "reactome": "R-DDI-200652", "name": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200709" ], "products": [ "species_200665" ], "modifiers": [ [ "species_10587374", "catalyst" ] ], "additional_components": [ "DDB_G0272544" ] }, "reaction_10587408": { "compartment": "compartment_70101", "id": "reaction_10587408", "reactome": "R-DDI-200711", "name": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29460", "species_197969" ], "products": [ "species_29372", "species_29370", "species_111353" ], "modifiers": [ [ "species_10587369", "catalyst" ] ], "additional_components": [ "Q54RI8", "DDB_G0283121" ] }, "reaction_10587410": { "compartment": "compartment_70101", "id": "reaction_10587410", "reactome": "R-DDI-200718", "name": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200640" ], "products": [ "species_29366", "species_200739" ], "modifiers": [ [ "species_10587369", "catalyst" ] ], "additional_components": [ "Q54RI8", "DDB_G0283121" ] }, "reaction_10616982": { "compartment": "compartment_70101", "id": "reaction_10616982", "reactome": "R-DDI-6808496", "name": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111353", "species_29366" ], "products": [ "species_70106", "species_113528", "species_29364", "species_197969" ], "modifiers": [ [ "species_10616979", "catalyst" ] ], "additional_components": [ "Q54FY1", "DDB_G0290537", "Q54FY3", "DDB_G0290479", "Q54FY2", "DDB_G0290537" ] }, "reaction_10587380": { "compartment": "compartment_70101", "id": "reaction_10587380", "reactome": "R-DDI-200661", "name": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111353" ], "products": [ "species_29356", "species_200640" ], "modifiers": [ [ "species_10587369", "catalyst" ] ], "additional_components": [ "Q54RI8", "DDB_G0283121" ] }, "reaction_10586903": { "compartment": "compartment_70101", "id": "reaction_10586903", "reactome": "R-DDI-197958", "name": "FPGS-2 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_111355", "species_113592" ], "products": [ "species_29372", "species_29370", "species_197969" ], "modifiers": [ [ "species_10586900", "catalyst" ] ], "additional_components": [ "DDB_G0292632" ] }, "reaction_10587414": { "compartment": "compartment_70101", "id": "reaction_10587414", "reactome": "R-DDI-200740", "name": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_200640" ], "products": [ "species_111353" ], "modifiers": [ [ "species_10587369", "catalyst" ] ], "additional_components": [ "Q54RI8", "DDB_G0283121" ] }, "reaction_10627480": { "compartment": "compartment_70101", "id": "reaction_10627480", "reactome": "R-DDI-9709098", "name": "DHFR dimer reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197965", "species_70106", "species_29364" ], "products": [ "species_29366", "species_73604" ], "modifiers": [ [ "species_10627477", "catalyst" ] ], "additional_components": [ "Q54LA0", "DDB_G0286755" ] }, "reaction_10586911": { "compartment": "compartment_70101", "id": "reaction_10586911", "reactome": "R-DDI-197963", "name": "DHFR2 reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197965", "species_70106", "species_29364" ], "products": [ "species_29366", "species_73604" ], "modifiers": [ [ "species_10586908", "catalyst" ] ], "additional_components": [ "DDB_G0286755" ] }, "reaction_10616511": { "compartment": "compartment_5460", "id": "reaction_10616511", "reactome": "R-DDI-6801328", "name": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_5693984" ], "products": [ "species_6801458", "species_29362" ], "modifiers": [ [ "species_10616508", "catalyst" ] ], "additional_components": [ "Q54RI8", "DDB_G0283121", "Q54VK0", "DDB_G0283121" ] }, "reaction_10612190": { "compartment": "compartment_5460", "id": "reaction_10612190", "reactome": "R-DDI-5696839", "name": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6801451", "species_200671", "species_113593" ], "products": [ "species_113548", "species_113581", "species_5389850" ], "modifiers": [ [ "species_10612187", "catalyst" ] ], "additional_components": [ "Q54RI8", "DDB_G0283121", "Q54VK0", "DDB_G0283121" ] }, "reaction_10587390": { "compartment": "compartment_70101", "id": "reaction_10587390", "reactome": "R-DDI-200676", "name": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200739" ], "products": [ "species_29366", "species_174404" ], "modifiers": [ [ "species_10587387", "catalyst" ] ], "additional_components": [ "Q54X84", "DDB_G0279137" ] }, "reaction_10601859": { "compartment": "compartment_70101", "id": "reaction_10601859", "reactome": "R-DDI-3000238", "name": "LMBRD1 transports lysosomal Cbl to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3000239" ], "products": [ "species_3000241" ], "modifiers": [ [ "species_10601856", "catalyst" ] ], "additional_components": [ "DDB_G0287405" ] }, "reaction_10602051": { "compartment": "compartment_70101", "id": "reaction_10602051", "reactome": "R-DDI-3149518", "name": "MTRR reduces cob(II)alamin to meCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_71284", "species_29364", "species_10602048" ], "products": [ "species_29366", "species_10585476", "species_71285" ], "modifiers": [ [ "species_10602048", "catalyst" ] ], "additional_components": [ "species_3149479", "species_76629", "Q55G48", "DDB_G0267824", "species_113596", "Q54P92", "DDB_G0284699", "species_29426", "Q54P92", "DDB_G0284699", "species_29426", "CHEBI:28115", "species_76629", "Q55G48", "DDB_G0267824", "species_113596", "species_3149479", "species_76629", "Q55G48", "DDB_G0267824", "species_113596", "Q54P92", "DDB_G0284699", "species_29426" ] }, "reaction_10602067": { "compartment": "compartment_5460", "id": "reaction_10602067", "reactome": "R-DDI-3159253", "name": "MMAB transfers adenosyl group from ATP to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3159260", "species_113593" ], "products": [ "species_3159274", "species_3159297" ], "modifiers": [ [ "species_10602064", "catalyst" ] ], "additional_components": [ "Q54W51", "DDB_G0279905" ] }, "reaction_10602084": { "compartment": "compartment_70101", "id": "reaction_10602084", "reactome": "R-DDI-3204318", "name": "cob(II)alamin binds to MTRR:MTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602046", "species_3149479" ], "products": [ "species_10602048" ], "modifiers": [], "additional_components": [ "species_76629", "Q55G48", "DDB_G0267824", "species_113596", "Q54P92", "DDB_G0284699", "species_29426", "species_3149479", "species_76629", "Q55G48", "DDB_G0267824", "species_113596", "Q54P92", "DDB_G0284699", "species_29426" ] }, "reaction_10602054": { "compartment": "compartment_70101", "id": "reaction_10602054", "reactome": "R-DDI-3149519", "name": "MMACHC decyanates CNCbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_10601956", "species_29364", "species_3149505" ], "products": [ "species_10601958", "species_29366", "species_1130611" ], "modifiers": [ [ "species_10601956", "catalyst" ] ], "additional_components": [ "DDB_G0274205", "Q86KB5", "DDB_G0274205", "species_3149479", "DDB_G0274205" ] }, "reaction_10601961": { "compartment": "compartment_70101", "id": "reaction_10601961", "reactome": "R-DDI-3095889", "name": "MMACHC reduces Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3000241", "species_70106", "species_10601956", "species_29364" ], "products": [ "species_10601958", "species_29366" ], "modifiers": [ [ "species_10601956", "catalyst" ] ], "additional_components": [ "DDB_G0274205", "Q86KB5", "DDB_G0274205", "species_3149479", "DDB_G0274205" ] }, "reaction_10602057": { "compartment": "compartment_70101", "id": "reaction_10602057", "reactome": "R-DDI-3149539", "name": "MTR transfers CH3 group from MTHF to cob(I)alamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200665", "species_10585480" ], "products": [ "species_111355", "species_10585476" ], "modifiers": [ [ "species_10585480", "catalyst" ] ], "additional_components": [ "Q54P92", "DDB_G0284699", "species_29426", "species_3159260", "species_76629", "Q55G48", "DDB_G0267824", "species_113596", "Q54P92", "DDB_G0284699", "species_29426", "CHEBI:28115", "species_76629", "Q55G48", "DDB_G0267824", "species_113596", "Q54P92", "DDB_G0284699", "species_29426", "species_3159260", "species_76629", "Q55G48", "DDB_G0267824", "species_113596" ] }, "reaction_10604780": { "compartment": "compartment_70101", "id": "reaction_10604780", "reactome": "R-DDI-5223313", "name": "ABCD4 may transport Cbl from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_3000239" ], "products": [ "species_29372", "species_3000241", "species_29370" ], "modifiers": [ [ "species_10604777", "catalyst" ] ], "additional_components": [ "DDB_G0279919" ] }, "reaction_10601964": { "compartment": "compartment_70101", "id": "reaction_10601964", "reactome": "R-DDI-3095901", "name": "ABCC1 transports cytosolic Cbl to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_3000241", "species_113592" ], "products": [ "species_29372", "species_29370", "species_3000125" ], "modifiers": [ [ "species_10589142", "catalyst" ] ], "additional_components": [ "Q54JR2", "DDB_G0287691", "Q54LE6", "DDB_G0286559", "Q8ST87", "DDB_G0280977", "Q54P13", "DDB_G0284867", "Q54U44", "DDB_G0280973" ] }, "reaction_10620675": { "compartment": "compartment_70101", "id": "reaction_10620675", "reactome": "R-DDI-8869627", "name": "NMRK2 phosphorylates NR to yield NMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869377" ], "products": [ "species_8869353", "species_70106", "species_29370" ], "modifiers": [ [ "species_10620669", "catalyst" ] ], "additional_components": [ "Q8T154", "DDB_G0274559", "Q55EL3", "DDB_G0269034" ] }, "reaction_10620672": { "compartment": "compartment_70101", "id": "reaction_10620672", "reactome": "R-DDI-8869607", "name": "NMRK2 phosphorylates NAR to yield NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869365" ], "products": [ "species_70106", "species_29370", "species_197220" ], "modifiers": [ [ "species_10620669", "catalyst" ] ], "additional_components": [ "Q8T154", "DDB_G0274559", "Q55EL3", "DDB_G0269034" ] }, "reaction_10586867": { "compartment": "compartment_70101", "id": "reaction_10586867", "reactome": "R-DDI-197198", "name": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29360" ], "products": [ "species_29370", "species_29366" ], "modifiers": [ [ "species_10586864", "catalyst" ] ], "additional_components": [ "species_29426", "Q54D76", "DDB_G0292442" ] }, "reaction_10586885": { "compartment": "compartment_70101", "id": "reaction_10586885", "reactome": "R-DDI-197268", "name": "QPRT transfers PRIB to QUIN to form NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_70106", "species_197238" ], "products": [ "species_111294", "species_113528", "species_197220" ], "modifiers": [ [ "species_10586882", "catalyst" ] ], "additional_components": [ "DDB_G0272462" ] }, "reaction_10620678": { "compartment": "compartment_70101", "id": "reaction_10620678", "reactome": "R-DDI-8869633", "name": "NMRK1 phosphorylates NR to yield NMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869377" ], "products": [ "species_8869353", "species_70106", "species_29370" ], "modifiers": [ [ "species_10620660", "catalyst" ] ], "additional_components": [ "Q8T154", "DDB_G0274559", "Q55EL3", "DDB_G0269034" ] }, "reaction_10616677": { "compartment": "compartment_5460", "id": "reaction_10616677", "reactome": "R-DDI-6806967", "name": "CARKD dehydrates S-NAD(P)HX to NADPH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_6807477" ], "products": [ "species_113548", "species_113581", "species_113529", "species_113600" ], "modifiers": [ [ "species_10616674", "catalyst" ] ], "additional_components": [ "DDB_G0290799" ] }, "reaction_10586857": { "compartment": "compartment_70101", "id": "reaction_10586857", "reactome": "R-DDI-197186", "name": "NAPRT1 dimer transfers PRIB to NCA to form NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_197230", "species_70106" ], "products": [ "species_111294", "species_197220" ], "modifiers": [ [ "species_10586854", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q55G10", "DDB_G0268472" ] }, "reaction_10617321": { "compartment": "compartment_17951", "id": "reaction_10617321", "reactome": "R-DDI-6809287", "name": "NUDT12 hydrolyses NADH to NMNH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_192305", "species_389620" ], "products": [ "species_6809289", "species_193465" ], "modifiers": [ [ "species_10617318", "catalyst" ] ], "additional_components": [ "DDB_G0272048" ] }, "reaction_10623038": { "compartment": "compartment_70101", "id": "reaction_10623038", "reactome": "R-DDI-8938073", "name": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8938276", "species_29360" ], "products": [ "species_197277", "species_8938282" ], "modifiers": [ [ "species_10623035", "catalyst" ] ], "additional_components": [ "Q54JP6", "DDB_G0287911" ] }, "reaction_10616669": { "compartment": "compartment_5460", "id": "reaction_10616669", "reactome": "R-DDI-6806966", "name": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6807473" ], "products": [ "species_6807477" ], "modifiers": [ [ "species_10616666", "catalyst" ] ], "additional_components": [ "Q55CV0", "DDB_G0269890" ] }, "reaction_10620663": { "compartment": "compartment_70101", "id": "reaction_10620663", "reactome": "R-DDI-8869606", "name": "NMRK1 phosphorylates NAR to yield NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869365" ], "products": [ "species_70106", "species_29370", "species_197220" ], "modifiers": [ [ "species_10620660", "catalyst" ] ], "additional_components": [ "Q8T154", "DDB_G0274559", "Q55EL3", "DDB_G0269034" ] }, "reaction_10587352": { "compartment": "compartment_5460", "id": "reaction_10587352", "reactome": "R-DDI-200474", "name": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8938083", "species_113593" ], "products": [ "species_8938078", "species_8938090" ], "modifiers": [ [ "species_10587349", "catalyst" ] ], "additional_components": [ "Q54IH4", "DDB_G0288757", "species_29926" ] }, "reaction_10623128": { "compartment": "compartment_70101", "id": "reaction_10623128", "reactome": "R-DDI-8939959", "name": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8869353", "species_113592" ], "products": [ "species_1132084", "species_29360" ], "modifiers": [ [ "species_10586874", "catalyst" ] ], "additional_components": [ "species_29926", "Q54IH4", "DDB_G0288757" ] }, "reaction_10586877": { "compartment": "compartment_70101", "id": "reaction_10586877", "reactome": "R-DDI-197235", "name": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_197220" ], "products": [ "species_197256", "species_1132084" ], "modifiers": [ [ "species_10586874", "catalyst" ] ], "additional_components": [ "species_29926", "Q54IH4", "DDB_G0288757" ] }, "reaction_10586895": { "compartment": "compartment_70101", "id": "reaction_10586895", "reactome": "R-DDI-197271", "name": "NADSYN1 hexamer amidates NAAD to NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_197256", "species_113592", "species_29472" ], "products": [ "species_111294", "species_29404", "species_76577", "species_29360" ], "modifiers": [ [ "species_10586892", "catalyst" ] ], "additional_components": [ "Q54ML1", "DDB_G0285877" ] }, "reaction_10587359": { "compartment": "compartment_7660", "id": "reaction_10587359", "reactome": "R-DDI-200512", "name": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200492", "species_29358" ], "products": [ "species_8878981", "species_200499" ], "modifiers": [ [ "species_10587356", "catalyst" ] ], "additional_components": [ "Q54IH4", "DDB_G0288757", "species_29426" ] }, "reaction_10597890": { "compartment": "compartment_70101", "id": "reaction_10597890", "reactome": "R-DDI-1474184", "name": "DHNTP is dephosphorylated by PTPS to PTHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1474124" ], "products": [ "species_1475054", "species_1474179" ], "modifiers": [ [ "species_10597887", "catalyst" ] ], "additional_components": [ "species_29426", "Q1ZXI0", "DDB_G0279095" ] }, "reaction_10598274": { "compartment": "compartment_70101", "id": "reaction_10598274", "reactome": "R-DDI-1497853", "name": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10598272" ], "products": [ "species_10597898", "species_29370" ], "modifiers": [ [ "species_10597913", "catalyst" ] ], "additional_components": [ "Q54GP3", "DDB_G0290009", "Q54GP3", "DDB_G0290009", "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029" ] }, "reaction_10597879": { "compartment": "compartment_70101", "id": "reaction_10597879", "reactome": "R-DDI-1474146", "name": "GCH1 reduces GTP to dihydroneopterin triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29356" ], "products": [ "species_1474124", "species_29460" ], "modifiers": [ [ "species_10597876", "catalyst" ], [ "species_29502", "catalyst" ], [ "species_29870", "inhibitor" ] ], "additional_components": [ "Q94465", "DDB_G0288481" ] }, "reaction_10597901": { "compartment": "compartment_70101", "id": "reaction_10597901", "reactome": "R-DDI-1475414", "name": "PTHP is reduced to BH4 by sepiapterin reductase (SPR)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1474179", "species_29364" ], "products": [ "species_29870", "species_29366" ], "modifiers": [ [ "species_10597898", "catalyst" ] ], "additional_components": [ "Q54GP3", "DDB_G0290009" ] }, "reaction_10597916": { "compartment": "compartment_70101", "id": "reaction_10597916", "reactome": "R-DDI-1475422", "name": "PTPS is phosphorylated by cGMP-dependant protein kinase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10597905" ], "products": [ "species_10597887", "species_29370" ], "modifiers": [ [ "species_10597913", "catalyst" ] ], "additional_components": [ "Q1ZXI0", "DDB_G0279095", "species_29426", "Q1ZXI0", "DDB_G0279095", "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029" ] }, "reaction_10600514": { "compartment": "compartment_5460", "id": "reaction_10600514", "reactome": "R-DDI-2162186", "name": "DeMQ10H2 is methylated to Q10H2 by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162265", "species_2162212" ], "products": [ "species_2162252", "species_113529", "species_2162198" ], "modifiers": [ [ "species_10600511", "catalyst" ] ], "additional_components": [ "DDB_G0279037" ] }, "reaction_10600522": { "compartment": "compartment_70616", "id": "reaction_10600522", "reactome": "R-DDI-2162192", "name": "PHB and all-E-10PrP2 are combined into DHB by COQ2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162214", "species_2162213" ], "products": [ "species_2162207", "species_159450" ], "modifiers": [ [ "species_10600519", "catalyst" ] ], "additional_components": [ "DDB_G0281241" ] }, "reaction_10600541": { "compartment": "compartment_5460", "id": "reaction_10600541", "reactome": "R-DDI-2162253", "name": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162257", "species_2162256" ], "products": [ "species_159450", "species_2162214" ], "modifiers": [ [ "species_10600538", "catalyst" ] ], "additional_components": [ "Q54VJ9", "DDB_G0280293", "species_29926" ] }, "reaction_10600525": { "compartment": "compartment_5460", "id": "reaction_10600525", "reactome": "R-DDI-2162193", "name": "DHDB is methylated to MHDB by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162265", "species_2162209" ], "products": [ "species_2162252", "species_113529", "species_2162215" ], "modifiers": [ [ "species_10600511", "catalyst" ] ], "additional_components": [ "DDB_G0279037" ] }, "reaction_10616648": { "compartment": "compartment_17957", "id": "reaction_10616648", "reactome": "R-DDI-6806674", "name": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6806891", "species_6806657" ], "products": [ "species_6806362", "species_6806656" ], "modifiers": [ [ "species_10616645", "catalyst" ] ], "additional_components": [ "DDB_G0287509" ] }, "reaction_10600503": { "compartment": "compartment_70101", "id": "reaction_10600503", "reactome": "R-DDI-2162066", "name": "carbovir + IMP => carbovir monophosphate + inosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161514", "species_29602" ], "products": [ "species_2161176", "species_83927" ], "modifiers": [ [ "species_10581209", "catalyst" ] ], "additional_components": [ "Q54XC1", "DDB_G0279053", "species_29926" ] }, "reaction_10600506": { "compartment": "compartment_70101", "id": "reaction_10600506", "reactome": "R-DDI-2162078", "name": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161185", "species_29360" ], "products": [ "species_70106", "species_2162081", "species_73473" ], "modifiers": [ [ "species_10578698", "catalyst" ] ], "additional_components": [ "species_29426", "Q54TC2", "DDB_G0281865" ] }, "reaction_10599457": { "compartment": "compartment_70101", "id": "reaction_10599457", "reactome": "R-DDI-1855205", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994170" ], "products": [ "species_29372", "species_114520" ], "modifiers": [ [ "species_10599454", "catalyst" ] ], "additional_components": [ "species_29926", "Q8T9S7", "DDB_G0286557" ] }, "reaction_10599491": { "compartment": "compartment_876", "id": "reaction_10599491", "reactome": "R-DDI-1855213", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994170" ], "products": [ "species_29372", "species_994123" ], "modifiers": [ [ "species_10599488", "catalyst" ] ], "additional_components": [ "Q54PV1", "DDB_G0284187", "Q54W40", "DDB_G0279927", "Q8I7P3", "DDB_G0267462" ] }, "reaction_10599381": { "compartment": "compartment_70101", "id": "reaction_10599381", "reactome": "R-DDI-1855169", "name": "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629741" ], "products": [ "species_994146", "species_29370" ], "modifiers": [ [ "species_10599364", "catalyst" ] ], "additional_components": [ "species_29926", "Q55D87", "DDB_G0269746" ] }, "reaction_10599367": { "compartment": "compartment_70101", "id": "reaction_10599367", "reactome": "R-DDI-1855159", "name": "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994146", "species_29356" ], "products": [ "species_29372", "species_1629741" ], "modifiers": [ [ "species_10599364", "catalyst" ] ], "additional_components": [ "species_29926", "Q55D87", "DDB_G0269746" ] }, "reaction_10599417": { "compartment": "compartment_70101", "id": "reaction_10599417", "reactome": "R-DDI-1855177", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10599414", "catalyst" ] ], "additional_components": [ "Q02158", "DDB_G0292736", "species_74112" ] }, "reaction_10599449": { "compartment": "compartment_70101", "id": "reaction_10599449", "reactome": "R-DDI-1855197", "name": "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994123" ], "products": [ "species_994146", "species_29370" ], "modifiers": [ [ "species_10599364", "catalyst" ] ], "additional_components": [ "species_29926", "Q55D87", "DDB_G0269746" ] }, "reaction_10599288": { "compartment": "compartment_70101", "id": "reaction_10599288", "reactome": "R-DDI-1855153", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_114520" ], "products": [ "species_29370", "species_994170" ], "modifiers": [ [ "species_10599285", "catalyst" ] ], "additional_components": [ "Q54TI0", "DDB_G0281737", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917" ] }, "reaction_10599384": { "compartment": "compartment_70101", "id": "reaction_10599384", "reactome": "R-DDI-1855171", "name": "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994146", "species_29356" ], "products": [ "species_29372", "species_994123" ], "modifiers": [ [ "species_10599364", "catalyst" ] ], "additional_components": [ "species_29926", "Q55D87", "DDB_G0269746" ] }, "reaction_10599547": { "compartment": "compartment_876", "id": "reaction_10599547", "reactome": "R-DDI-1855221", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10599544", "catalyst" ] ], "additional_components": [ "Q02158", "DDB_G0292736", "species_74112" ] }, "reaction_10599387": { "compartment": "compartment_70101", "id": "reaction_10599387", "reactome": "R-DDI-1855172", "name": "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994123" ], "products": [ "species_29370", "species_994170" ], "modifiers": [ [ "species_10599364", "catalyst" ] ], "additional_components": [ "species_29926", "Q55D87", "DDB_G0269746" ] }, "reaction_10599514": { "compartment": "compartment_12045", "id": "reaction_10599514", "reactome": "R-DDI-1855214", "name": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023856", "species_29356" ], "products": [ "species_114520", "species_1500596" ], "modifiers": [ [ "species_10599511", "catalyst" ] ], "additional_components": [ "Q54SA1", "DDB_G0282579", "Q54K50", "DDB_G0287649", "species_74112", "Q02158", "DDB_G0292736" ] }, "reaction_10599519": { "compartment": "compartment_70101", "id": "reaction_10599519", "reactome": "R-DDI-1855218", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994170" ], "products": [ "species_29372", "species_994123" ], "modifiers": [ [ "species_10599516", "catalyst" ] ], "additional_components": [ "species_29926", "Q55D87", "DDB_G0269746", "Q8I7P3", "DDB_G0267462", "Q54PV1", "DDB_G0284187", "Q54W40", "DDB_G0279927", "Q54D97", "DDB_G0292392" ] }, "reaction_10599345": { "compartment": "compartment_7660", "id": "reaction_10599345", "reactome": "R-DDI-1855157", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023932" ], "products": [ "species_113582", "species_2023931" ], "modifiers": [ [ "species_10599342", "catalyst" ] ], "additional_components": [ "Q54B75", "DDB_G0293860", "Q55AP4", "DDB_G0293860", "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0293860" ] }, "reaction_10599440": { "compartment": "compartment_7660", "id": "reaction_10599440", "reactome": "R-DDI-1855185", "name": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023935" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10599437", "catalyst" ] ], "additional_components": [ "DDB_G0281737" ] }, "reaction_10599568": { "compartment": "compartment_7660", "id": "reaction_10599568", "reactome": "R-DDI-1855230", "name": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023922" ], "products": [ "species_113582", "species_2023948" ], "modifiers": [ [ "species_10599342", "catalyst" ] ], "additional_components": [ "Q54B75", "DDB_G0293860", "Q55AP4", "DDB_G0293860", "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0293860" ] }, "reaction_10599460": { "compartment": "compartment_7660", "id": "reaction_10599460", "reactome": "R-DDI-1855206", "name": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023891" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10599437", "catalyst" ] ], "additional_components": [ "DDB_G0281737" ] }, "reaction_10599556": { "compartment": "compartment_7660", "id": "reaction_10599556", "reactome": "R-DDI-1855224", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023940" ], "products": [ "species_113582", "species_2023941" ], "modifiers": [ [ "species_10599342", "catalyst" ] ], "additional_components": [ "Q54B75", "DDB_G0293860", "Q55AP4", "DDB_G0293860", "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0293860" ] }, "reaction_10599463": { "compartment": "compartment_7660", "id": "reaction_10599463", "reactome": "R-DDI-1855207", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023929" ], "products": [ "species_113582", "species_2023940" ], "modifiers": [ [ "species_10599342", "catalyst" ] ], "additional_components": [ "Q54B75", "DDB_G0293860", "Q55AP4", "DDB_G0293860", "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0293860" ] }, "reaction_10599574": { "compartment": "compartment_7660", "id": "reaction_10599574", "reactome": "R-DDI-1855233", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023907" ], "products": [ "species_113582", "species_2023891" ], "modifiers": [ [ "species_10599437", "catalyst" ] ], "additional_components": [ "DDB_G0281737" ] }, "reaction_10599400": { "compartment": "compartment_7660", "id": "reaction_10599400", "reactome": "R-DDI-1855176", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023901" ], "products": [ "species_113582", "species_2023929" ], "modifiers": [ [ "species_10599397", "catalyst" ] ], "additional_components": [ "DDB_G0288351" ] }, "reaction_10599435": { "compartment": "compartment_7660", "id": "reaction_10599435", "reactome": "R-DDI-1855181", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023901" ], "products": [ "species_113582", "species_2023922" ], "modifiers": [ [ "species_10599342", "catalyst" ] ], "additional_components": [ "Q54B75", "DDB_G0293860", "Q55AP4", "DDB_G0293860", "Q54QM1", "DDB_G0293860", "Q54XR3", "DDB_G0293860" ] }, "reaction_10599565": { "compartment": "compartment_7660", "id": "reaction_10599565", "reactome": "R-DDI-1855228", "name": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023892" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10599437", "catalyst" ] ], "additional_components": [ "DDB_G0281737" ] }, "reaction_10599473": { "compartment": "compartment_70101", "id": "reaction_10599473", "reactome": "R-DDI-1855210", "name": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629731" ], "products": [ "species_29372", "species_426910" ], "modifiers": [ [ "species_10599305", "catalyst" ] ], "additional_components": [ "species_29926", "Q54U72", "DDB_G0281239" ] }, "reaction_10607633": { "compartment": "compartment_70101", "id": "reaction_10607633", "reactome": "R-DDI-5678327", "name": "MIOX oxidises Ins to GlcA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_426910" ], "products": [ "species_29356", "species_70106", "species_2162232" ], "modifiers": [ [ "species_10607630", "catalyst" ] ], "additional_components": [ "species_71067", "Q54GH4", "DDB_G0290161" ] }, "reaction_10599392": { "compartment": "compartment_70101", "id": "reaction_10599392", "reactome": "R-DDI-1855174", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_114520" ], "products": [ "species_29372", "species_1629739" ], "modifiers": [ [ "species_10599389", "catalyst" ] ], "additional_components": [ "Q8I7P3", "DDB_G0267462", "Q54PV1", "DDB_G0284187", "Q54W40", "DDB_G0279927", "Q54D97", "DDB_G0292392" ] }, "reaction_10599571": { "compartment": "compartment_70101", "id": "reaction_10599571", "reactome": "R-DDI-1855232", "name": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994123" ], "products": [ "species_29372", "species_1629746" ], "modifiers": [ [ "species_10599467", "catalyst" ] ], "additional_components": [ "species_29926", "Q869K3", "DDB_G0275663" ] }, "reaction_10599427": { "compartment": "compartment_70101", "id": "reaction_10599427", "reactome": "R-DDI-1855178", "name": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629756" ], "products": [ "species_1629731" ], "modifiers": [ [ "species_10599424", "catalyst" ] ], "additional_components": [ "species_29360", "Q54N49", "DDB_G0285505" ] }, "reaction_10599476": { "compartment": "compartment_70101", "id": "reaction_10599476", "reactome": "R-DDI-1855211", "name": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629753" ], "products": [ "species_29372", "species_426910" ], "modifiers": [ [ "species_10599305", "catalyst" ] ], "additional_components": [ "species_29926", "Q54U72", "DDB_G0281239" ] }, "reaction_10599308": { "compartment": "compartment_70101", "id": "reaction_10599308", "reactome": "R-DDI-1855154", "name": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_870330" ], "products": [ "species_29372", "species_426910" ], "modifiers": [ [ "species_10599305", "catalyst" ] ], "additional_components": [ "species_29926", "Q54U72", "DDB_G0281239" ] }, "reaction_10599550": { "compartment": "compartment_876", "id": "reaction_10599550", "reactome": "R-DDI-1855222", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_114520" ], "products": [ "species_29372", "species_1629739" ], "modifiers": [ [ "species_10599484", "catalyst" ] ], "additional_components": [ "Q54PV1", "DDB_G0284187", "Q54W40", "DDB_G0279927", "Q8I7P3", "DDB_G0267462" ] }, "reaction_10599470": { "compartment": "compartment_70101", "id": "reaction_10599470", "reactome": "R-DDI-1855208", "name": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629739" ], "products": [ "species_29372", "species_1629753" ], "modifiers": [ [ "species_10599467", "catalyst" ] ], "additional_components": [ "species_29926", "Q869K3", "DDB_G0275663" ] }, "reaction_10599378": { "compartment": "compartment_17957", "id": "reaction_10599378", "reactome": "R-DDI-1855163", "name": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_2024008" ], "products": [ "species_113551", "species_2024012" ], "modifiers": [ [ "species_10599375", "catalyst" ] ], "additional_components": [ "DDB_G0286993" ] }, "reaction_10599559": { "compartment": "compartment_17957", "id": "reaction_10599559", "reactome": "R-DDI-1855225", "name": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_2024018" ], "products": [ "species_113551", "species_2564836" ], "modifiers": [ [ "species_10599375", "catalyst" ] ], "additional_components": [ "DDB_G0286993" ] }, "reaction_10599452": { "compartment": "compartment_17957", "id": "reaction_10599452", "reactome": "R-DDI-1855200", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_2024002" ], "products": [ "species_113551", "species_2024016" ], "modifiers": [ [ "species_10599375", "catalyst" ] ], "additional_components": [ "DDB_G0286993" ] }, "reaction_10583665": { "compartment": "compartment_70101", "id": "reaction_10583665", "reactome": "R-DDI-156526", "name": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_5423605", "species_29364" ], "products": [ "species_29356", "species_159211", "species_29366" ], "modifiers": [ [ "species_10582258", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10605385": { "compartment": "compartment_70101", "id": "reaction_10605385", "reactome": "R-DDI-5433074", "name": "ACY1:Zn2+ dimer hydrolyses mercapturic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5490236", "species_29356" ], "products": [ "species_2022890", "species_5490231" ], "modifiers": [ [ "species_10605382", "catalyst" ] ], "additional_components": [ "CHEBI:78580", "CHEBI:78585", "CHEBI:78583", "CHEBI:78578", "species_29426", "Q55DP8", "DDB_G0270562" ] }, "reaction_10605373": { "compartment": "compartment_70101", "id": "reaction_10605373", "reactome": "R-DDI-5423647", "name": "CYP2A13 oxidises AFM1 to AFM1E", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5423629", "species_70106", "species_29368", "species_29364" ], "products": [ "species_29356", "species_5423657", "species_29366" ], "modifiers": [ [ "species_10582258", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10605375": { "compartment": "compartment_70101", "id": "reaction_10605375", "reactome": "R-DDI-5423653", "name": "MGST trimers transfer GS from GSH to AFXBO and AFNBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_5423723" ], "products": [ "species_5423730" ], "modifiers": [ [ "species_10585705", "catalyst" ] ], "additional_components": [ "species_159211", "CHEBI:78586", "CHEBI:78581", "CHEBI:78587", "Q54GA9", "DDB_G0290291" ] }, "reaction_10623024": { "compartment": "compartment_70101", "id": "reaction_10623024", "reactome": "R-DDI-8937442", "name": "CES3 hydrolyses CHEST to CHOL and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_163579" ], "products": [ "species_8876730", "species_216762" ], "modifiers": [ [ "species_10623021", "catalyst" ] ], "additional_components": [ "P21837", "DDB_G0285419", "P18142", "DDB_G0283085", "Q54N21", "DDB_G0291344", "Q54ET7", "DDB_G0291344", "Q86L18", "DDB_G0291344", "Q54WD8", "DDB_G0291344" ] }, "reaction_10583621": { "compartment": "compartment_70101", "id": "reaction_10583621", "reactome": "R-DDI-141200", "name": "MAOB:FAD oxidatively deaminates of PEA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500605", "species_29368" ], "products": [ "species_500607", "species_29382", "species_29408" ], "modifiers": [ [ "species_10583618", "catalyst" ] ], "additional_components": [ "Q54IT3", "DDB_G0288541", "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10583623": { "compartment": "compartment_70101", "id": "reaction_10583623", "reactome": "R-DDI-141202", "name": "MAOB:FAD oxidatively deaminates TYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500606", "species_29368" ], "products": [ "species_500608", "species_29382", "species_29408" ], "modifiers": [ [ "species_10583618", "catalyst" ] ], "additional_components": [ "Q54IT3", "DDB_G0288541", "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10611904": { "compartment": "compartment_5460", "id": "reaction_10611904", "reactome": "R-DDI-5696091", "name": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113532", "species_113526", "species_113521" ], "products": [ "species_113529", "species_29362", "species_113539" ], "modifiers": [ [ "species_10611901", "catalyst" ] ], "additional_components": [ "Q54FY3", "DDB_G0290479", "Q54FY1", "DDB_G0290537", "Q54FY2", "DDB_G0290537" ] }, "reaction_10578691": { "compartment": "compartment_70101", "id": "reaction_10578691", "reactome": "R-DDI-71691", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29510", "species_29360" ], "products": [ "species_70106", "species_29416", "species_73473" ], "modifiers": [ [ "species_10578688", "catalyst" ] ], "additional_components": [ "Q54IU0", "DDB_G0288521" ] }, "reaction_10578727": { "compartment": "compartment_5460", "id": "reaction_10578727", "reactome": "R-DDI-71723", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113532", "species_113526", "species_113521" ], "products": [ "species_113529", "species_29362", "species_113539" ], "modifiers": [ [ "species_10578724", "catalyst" ] ], "additional_components": [ "Q54FY3", "DDB_G0290479" ] }, "reaction_10578745": { "compartment": "compartment_70101", "id": "reaction_10578745", "reactome": "R-DDI-71735", "name": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29416", "species_76194" ], "products": [ "species_111294", "species_76183", "species_76577" ], "modifiers": [ [ "species_10578742", "catalyst" ] ], "additional_components": [ "DDB_G0277815" ] }, "reaction_10578717": { "compartment": "compartment_70101", "id": "reaction_10578717", "reactome": "R-DDI-71707", "name": "ethanol + NAD+ => acetaldehyde + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30203", "species_29360" ], "products": [ "species_70106", "species_29510", "species_73473" ], "modifiers": [ [ "species_10578714", "catalyst" ] ], "additional_components": [ "species_29426", "Q54TC2", "DDB_G0281865" ] }, "reaction_10611260": { "compartment": "compartment_70101", "id": "reaction_10611260", "reactome": "R-DDI-5692237", "name": "ADH5 oxidises S-HMGSH to S-FGSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5692221", "species_29360" ], "products": [ "species_5692249", "species_70106", "species_73473" ], "modifiers": [ [ "species_10611257", "catalyst" ] ], "additional_components": [ "species_29426", "Q54TC2", "DDB_G0281865" ] }, "reaction_10593006": { "compartment": "compartment_5460", "id": "reaction_10593006", "reactome": "R-DDI-449911", "name": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_113539" ], "products": [ "species_159448", "species_159450", "species_113559" ], "modifiers": [ [ "species_10593003", "catalyst" ] ], "additional_components": [ "DDB_G0277815" ] }, "reaction_10588946": { "compartment": "compartment_17960", "id": "reaction_10588946", "reactome": "R-DDI-217258", "name": "FMO2:FAD:Mg2+ S-oxidises MTZ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_217315" ], "products": [ "species_113519", "species_113564", "species_217320" ], "modifiers": [ [ "species_10588943", "catalyst" ] ], "additional_components": [ "species_29926", "species_113596", "Q54GT1", "DDB_G0289931", "Q54GT2", "DDB_G0289931", "Q54GT4", "DDB_G0289931", "Q54H02", "DDB_G0289931", "Q54H99", "DDB_G0289931", "Q55AS8", "DDB_G0289931", "Q54GT0", "DDB_G0289931" ] }, "reaction_10588925": { "compartment": "compartment_17960", "id": "reaction_10588925", "reactome": "R-DDI-217255", "name": "FMO1:FAD N-oxidises TAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_159154" ], "products": [ "species_113519", "species_113564", "species_217269" ], "modifiers": [ [ "species_10588922", "catalyst" ] ], "additional_components": [ "species_113596", "Q54GT4", "DDB_G0289931", "Q54H02", "DDB_G0289931", "Q54H99", "DDB_G0289931", "Q55AS8", "DDB_G0289931", "Q54GT0", "DDB_G0289931", "Q54GT1", "DDB_G0289931", "Q54GT2", "DDB_G0289931" ] }, "reaction_10583597": { "compartment": "compartment_17957", "id": "reaction_10583597", "reactome": "R-DDI-139970", "name": "FMO3:FAD N-oxidises TMA to TMAO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_30373", "species_113601" ], "products": [ "species_113519", "species_113564", "species_140963" ], "modifiers": [ [ "species_10583594", "catalyst" ] ], "additional_components": [ "species_113596", "Q54H99", "DDB_G0289931", "Q54GT2", "DDB_G0289931", "Q54GT4", "DDB_G0289931", "Q55AS8", "DDB_G0289931", "Q54GT0", "DDB_G0289931", "Q54GT1", "DDB_G0289931", "Q54H02", "DDB_G0289931" ] }, "reaction_10611272": { "compartment": "compartment_70101", "id": "reaction_10611272", "reactome": "R-DDI-5692283", "name": "ALD3A1 oxidises 4HPCP to CXPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5692409", "species_29356", "species_29366" ], "products": [ "species_70106", "species_5692433", "species_29364" ], "modifiers": [ [ "species_10611269", "catalyst" ] ], "additional_components": [ "DDB_G0292270" ] }, "reaction_10608763": { "compartment": "compartment_12045", "id": "reaction_10608763", "reactome": "R-DDI-5689000", "name": "AADAC deacetylates PHEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5689006" ], "products": [ "species_5689001", "species_5688995" ], "modifiers": [ [ "species_10608760", "catalyst" ] ], "additional_components": [ "DDB_G0283819" ] }, "reaction_10611434": { "compartment": "compartment_17957", "id": "reaction_10611434", "reactome": "R-DDI-5693691", "name": "CES1 trimer.CES2 hydrolyse COCN to BEG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_5693702" ], "products": [ "species_156540", "species_5693711", "species_5693712" ], "modifiers": [ [ "species_10611431", "catalyst" ] ], "additional_components": [ "Q54WD8", "DDB_G0291344", "Q86L18", "DDB_G0291344", "P18142", "DDB_G0283085", "P21837", "DDB_G0285419", "Q54ET7", "DDB_G0291344", "Q54N21", "DDB_G0291344" ] }, "reaction_10588801": { "compartment": "compartment_12045", "id": "reaction_10588801", "reactome": "R-DDI-211910", "name": "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_211906", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211894" ], "modifiers": [ [ "species_10588798", "catalyst" ] ], "additional_components": [ "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778" ] }, "reaction_10588881": { "compartment": "compartment_12045", "id": "reaction_10588881", "reactome": "R-DDI-212005", "name": "CYP2F1 dehydrogenates 3-methylindole", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_213162", "species_113601" ], "products": [ "species_113519", "species_113564", "species_213163" ], "modifiers": [ [ "species_10588871", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10588803": { "compartment": "compartment_12045", "id": "reaction_10588803", "reactome": "R-DDI-211929", "name": "CYP2C19 5-hydroxylates omeprazole", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_211892", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211944" ], "modifiers": [ [ "species_10588798", "catalyst" ] ], "additional_components": [ "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778" ] }, "reaction_10582274": { "compartment": "compartment_12045", "id": "reaction_10582274", "reactome": "R-DDI-76453", "name": "Coumarin is 7-hydroxylated by CYP2A6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_76328", "species_113601" ], "products": [ "species_113519", "species_113564", "species_76452" ], "modifiers": [ [ "species_10582271", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10588869": { "compartment": "compartment_12045", "id": "reaction_10588869", "reactome": "R-DDI-211988", "name": "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_211855", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211937" ], "modifiers": [ [ "species_10588798", "catalyst" ] ], "additional_components": [ "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778" ] }, "reaction_10582327": { "compartment": "compartment_12045", "id": "reaction_10582327", "reactome": "R-DDI-76456", "name": "O-atom dealkylation of dextromethorphan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_39703", "species_113601" ], "products": [ "species_143501", "species_113519", "species_113564", "species_76455" ], "modifiers": [ [ "species_10582324", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10588857": { "compartment": "compartment_12045", "id": "reaction_10588857", "reactome": "R-DDI-211966", "name": "CYP2D6 4-hydroxylates debrisoquine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_211993", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211952" ], "modifiers": [ [ "species_10582324", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10582263": { "compartment": "compartment_17960", "id": "reaction_10582263", "reactome": "R-DDI-76354", "name": "Vinyl chloride is oxidized to 2-Chloroethylene oxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_39417", "species_113601" ], "products": [ "species_156524", "species_113519", "species_113564" ], "modifiers": [ [ "species_10582260", "catalyst" ] ], "additional_components": [ "Q1ZXF5", "DDB_G0284535", "Q86A22", "DDB_G0272704", "Q54SK0", "DDB_G0282419", "Q54LA8", "DDB_G0286743", "Q54SV9", "DDB_G0282283", "Q1ZXG3", "DDB_G0282769", "Q54LT7", "DDB_G0286419", "Q1ZXL2", "DDB_G0275197", "Q54ZM4", "DDB_G0277545", "Q54NY3", "DDB_G0284923", "Q556M4", "DDB_G0272604", "Q1ZXL7", "DDB_G0273047", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54CS3", "DDB_G0292792", "Q1ZXA4", "DDB_G0292790", "Q556M5", "DDB_G0273045", "Q54QD0", "DDB_G0283933", "Q55AJ4", "DDB_G0271778", "Q54DT2", "DDB_G0292168", "Q54QD2", "DDB_G0283929", "Q1ZXF3", "DDB_G0284647", "Q54EM5", "DDB_G0291448" ] }, "reaction_10582265": { "compartment": "compartment_17957", "id": "reaction_10582265", "reactome": "R-DDI-76397", "name": "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_113564", "species_39427", "species_113555" ], "products": [ "species_113519", "species_76396", "species_113601" ], "modifiers": [ [ "species_10582260", "catalyst" ] ], "additional_components": [ "Q1ZXF5", "DDB_G0284535", "Q86A22", "DDB_G0272704", "Q54SK0", "DDB_G0282419", "Q54LA8", "DDB_G0286743", "Q54SV9", "DDB_G0282283", "Q1ZXG3", "DDB_G0282769", "Q54LT7", "DDB_G0286419", "Q1ZXL2", "DDB_G0275197", "Q54ZM4", "DDB_G0277545", "Q54NY3", "DDB_G0284923", "Q556M4", "DDB_G0272604", "Q1ZXL7", "DDB_G0273047", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54CS3", "DDB_G0292792", "Q1ZXA4", "DDB_G0292790", "Q556M5", "DDB_G0273045", "Q54QD0", "DDB_G0283933", "Q55AJ4", "DDB_G0271778", "Q54DT2", "DDB_G0292168", "Q54QD2", "DDB_G0283929", "Q1ZXF3", "DDB_G0284647", "Q54EM5", "DDB_G0291448" ] }, "reaction_10582329": { "compartment": "compartment_17960", "id": "reaction_10582329", "reactome": "R-DDI-76475", "name": "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_40795", "species_113601" ], "products": [ "species_113519", "species_113564", "species_76474", "species_76473" ], "modifiers": [ [ "species_10582260", "catalyst" ] ], "additional_components": [ "Q1ZXF5", "DDB_G0284535", "Q86A22", "DDB_G0272704", "Q54SK0", "DDB_G0282419", "Q54LA8", "DDB_G0286743", "Q54SV9", "DDB_G0282283", "Q1ZXG3", "DDB_G0282769", "Q54LT7", "DDB_G0286419", "Q1ZXL2", "DDB_G0275197", "Q54ZM4", "DDB_G0277545", "Q54NY3", "DDB_G0284923", "Q556M4", "DDB_G0272604", "Q1ZXL7", "DDB_G0273047", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54CS3", "DDB_G0292792", "Q1ZXA4", "DDB_G0292790", "Q556M5", "DDB_G0273045", "Q54QD0", "DDB_G0283933", "Q55AJ4", "DDB_G0271778", "Q54DT2", "DDB_G0292168", "Q54QD2", "DDB_G0283929", "Q1ZXF3", "DDB_G0284647", "Q54EM5", "DDB_G0291448" ] }, "reaction_10582267": { "compartment": "compartment_17960", "id": "reaction_10582267", "reactome": "R-DDI-76416", "name": "Benzene is hydroxylated to phenol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_31711", "species_156540", "species_113601" ], "products": [ "species_113519", "species_29630", "species_113564" ], "modifiers": [ [ "species_10582260", "catalyst" ] ], "additional_components": [ "Q1ZXF5", "DDB_G0284535", "Q86A22", "DDB_G0272704", "Q54SK0", "DDB_G0282419", "Q54LA8", "DDB_G0286743", "Q54SV9", "DDB_G0282283", "Q1ZXG3", "DDB_G0282769", "Q54LT7", "DDB_G0286419", "Q1ZXL2", "DDB_G0275197", "Q54ZM4", "DDB_G0277545", "Q54NY3", "DDB_G0284923", "Q556M4", "DDB_G0272604", "Q1ZXL7", "DDB_G0273047", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54CS3", "DDB_G0292792", "Q1ZXA4", "DDB_G0292790", "Q556M5", "DDB_G0273045", "Q54QD0", "DDB_G0283933", "Q55AJ4", "DDB_G0271778", "Q54DT2", "DDB_G0292168", "Q54QD2", "DDB_G0283929", "Q1ZXF3", "DDB_G0284647", "Q54EM5", "DDB_G0291448" ] }, "reaction_10582269": { "compartment": "compartment_17960", "id": "reaction_10582269", "reactome": "R-DDI-76434", "name": "Dehalogenation of carbon tetrachloride to form a free radical", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_40887" ], "products": [ "species_29572", "species_76433" ], "modifiers": [ [ "species_10582260", "catalyst" ] ], "additional_components": [ "Q1ZXF5", "DDB_G0284535", "Q86A22", "DDB_G0272704", "Q54SK0", "DDB_G0282419", "Q54LA8", "DDB_G0286743", "Q54SV9", "DDB_G0282283", "Q1ZXG3", "DDB_G0282769", "Q54LT7", "DDB_G0286419", "Q1ZXL2", "DDB_G0275197", "Q54ZM4", "DDB_G0277545", "Q54NY3", "DDB_G0284923", "Q556M4", "DDB_G0272604", "Q1ZXL7", "DDB_G0273047", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54CS3", "DDB_G0292792", "Q1ZXA4", "DDB_G0292790", "Q556M5", "DDB_G0273045", "Q54QD0", "DDB_G0283933", "Q55AJ4", "DDB_G0271778", "Q54DT2", "DDB_G0292168", "Q54QD2", "DDB_G0283929", "Q1ZXF3", "DDB_G0284647", "Q54EM5", "DDB_G0291448" ] }, "reaction_10583662": { "compartment": "compartment_17957", "id": "reaction_10583662", "reactome": "R-DDI-143468", "name": "MEOS oxidizes ethanol to acetaldehyde", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113748", "species_113601" ], "products": [ "species_113519", "species_113564", "species_113745" ], "modifiers": [ [ "species_10582260", "catalyst" ] ], "additional_components": [ "Q1ZXF5", "DDB_G0284535", "Q86A22", "DDB_G0272704", "Q54SK0", "DDB_G0282419", "Q54LA8", "DDB_G0286743", "Q54SV9", "DDB_G0282283", "Q1ZXG3", "DDB_G0282769", "Q54LT7", "DDB_G0286419", "Q1ZXL2", "DDB_G0275197", "Q54ZM4", "DDB_G0277545", "Q54NY3", "DDB_G0284923", "Q556M4", "DDB_G0272604", "Q1ZXL7", "DDB_G0273047", "Q54Q53", "DDB_G0284089", "Q1ZXA1", "DDB_G0293738", "Q54CS3", "DDB_G0292792", "Q1ZXA4", "DDB_G0292790", "Q556M5", "DDB_G0273045", "Q54QD0", "DDB_G0283933", "Q55AJ4", "DDB_G0271778", "Q54DT2", "DDB_G0292168", "Q54QD2", "DDB_G0283929", "Q1ZXF3", "DDB_G0284647", "Q54EM5", "DDB_G0291448" ] }, "reaction_10588874": { "compartment": "compartment_12045", "id": "reaction_10588874", "reactome": "R-DDI-211991", "name": "Cyclophosphamide is 4-hydroxylated by CYP2B6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_211977", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211967" ], "modifiers": [ [ "species_10588871", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10588796": { "compartment": "compartment_12045", "id": "reaction_10588796", "reactome": "R-DDI-211881", "name": "Coumarin is 7-hydroxylated by CYP2A13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_76328", "species_113601" ], "products": [ "species_113519", "species_113564", "species_76452" ], "modifiers": [ [ "species_10588793", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10588879": { "compartment": "compartment_12045", "id": "reaction_10588879", "reactome": "R-DDI-212004", "name": "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_211939" ], "products": [ "species_113519", "species_113564", "species_211927" ], "modifiers": [ [ "species_10588876", "catalyst" ] ], "additional_components": [ "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778" ] }, "reaction_10588791": { "compartment": "compartment_17960", "id": "reaction_10588791", "reactome": "R-DDI-211874", "name": "CYP2S1 4-hydroxylates atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_215573", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215584" ], "modifiers": [ [ "species_10582210", "catalyst" ] ], "additional_components": [ "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778" ] }, "reaction_10588854": { "compartment": "compartment_17960", "id": "reaction_10588854", "reactome": "R-DDI-211960", "name": "CYP2U1 19-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_216620", "species_113519", "species_113564" ], "modifiers": [ [ "species_10588851", "catalyst" ] ], "additional_components": [ "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10588862": { "compartment": "compartment_17960", "id": "reaction_10588862", "reactome": "R-DDI-211968", "name": "CYP2W1 oxidises INDOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_216547" ], "products": [ "species_113519", "species_113564", "species_216598" ], "modifiers": [ [ "species_10588859", "catalyst" ] ], "additional_components": [ "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778" ] }, "reaction_10588867": { "compartment": "compartment_17960", "id": "reaction_10588867", "reactome": "R-DDI-211983", "name": "CYP2J2 oxidises ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215062" ], "modifiers": [ [ "species_10588864", "catalyst" ] ], "additional_components": [ "CHEBI:34130", "CHEBI:34157", "species_2142739", "CHEBI:34490", "Q54QD0", "DDB_G0283933", "Q54QD2", "DDB_G0283929", "Q1ZXA1", "DDB_G0293738", "Q54SK0", "DDB_G0282419", "Q1ZXA4", "DDB_G0292790", "Q54SV9", "DDB_G0282283", "Q1ZXF3", "DDB_G0284647", "Q54ZM4", "DDB_G0277545", "Q1ZXF5", "DDB_G0284535", "Q556M4", "DDB_G0272604", "Q1ZXG3", "DDB_G0282769", "Q556M5", "DDB_G0273045", "Q1ZXL2", "DDB_G0275197", "Q55AJ4", "DDB_G0271778", "Q1ZXL7", "DDB_G0273047", "Q86A22", "DDB_G0272704", "Q54CS3", "DDB_G0292792", "Q54DT2", "DDB_G0292168", "Q54EM5", "DDB_G0291448", "Q54LA8", "DDB_G0286743", "Q54LT7", "DDB_G0286419", "Q54NY3", "DDB_G0284923", "Q54Q53", "DDB_G0284089" ] }, "reaction_10585571": { "compartment": "compartment_17957", "id": "reaction_10585571", "reactome": "R-DDI-174931", "name": "UGTs transfer GlcA from UDP-GlcA to O-centre substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174911", "species_174384" ], "products": [ "species_158602", "species_174914" ], "modifiers": [ [ "species_10585568", "catalyst" ] ], "additional_components": [ "species_39427", "CHEBI:16580", "species_211993", "species_29630", "CHEBI:32649", "CHEBI:65137", "CHEBI:64681", "CHEBI:32636", "Q54IL5", "DDB_G0288655", "Q55FB2", "DDB_G0268544", "Q55FX8", "DDB_G0268544", "Q55FY0", "DDB_G0268544" ] }, "reaction_10626273": { "compartment": "compartment_17957", "id": "reaction_10626273", "reactome": "R-DDI-9632039", "name": "UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159151", "species_174384" ], "products": [ "species_159160", "species_158602" ], "modifiers": [ [ "species_10585556", "catalyst" ] ], "additional_components": [ "DDB_G0288655" ] }, "reaction_10585554": { "compartment": "compartment_17957", "id": "reaction_10585554", "reactome": "R-DDI-174916", "name": "Formation of N-glucuronides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174932", "species_174384" ], "products": [ "species_158602", "species_174918" ], "modifiers": [ [ "species_10585551", "catalyst" ] ], "additional_components": [ "species_159154", "CHEBI:17688", "CHEBI:63860", "CHEBI:32663", "Q55FY0", "DDB_G0268544", "Q54IL5", "DDB_G0288655", "Q55FB2", "DDB_G0268544", "Q55FX8", "DDB_G0268544" ] }, "reaction_10623226": { "compartment": "compartment_12045", "id": "reaction_10623226", "reactome": "R-DDI-8941701", "name": "UGT1A10 transfers GlcA from UDP-GlcA to GCTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8941723", "species_174384" ], "products": [ "species_158602", "species_8941725" ], "modifiers": [ [ "species_10585549", "catalyst" ] ], "additional_components": [ "Q54IL5", "DDB_G0288655", "Q55FB2", "DDB_G0268544", "Q55FX8", "DDB_G0268544", "Q55FY0", "DDB_G0268544" ] }, "reaction_10583800": { "compartment": "compartment_17957", "id": "reaction_10583800", "reactome": "R-DDI-159179", "name": "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159160", "species_174384" ], "products": [ "species_159149", "species_158602" ], "modifiers": [ [ "species_10583797", "catalyst" ] ], "additional_components": [ "Q55FY0", "DDB_G0268544", "Q54IL5", "DDB_G0288655", "Q55FB2", "DDB_G0268544", "Q55FX8", "DDB_G0268544" ] }, "reaction_10583802": { "compartment": "compartment_17957", "id": "reaction_10583802", "reactome": "R-DDI-159194", "name": "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159151", "species_174384" ], "products": [ "species_159160", "species_158602" ], "modifiers": [ [ "species_10583797", "catalyst" ] ], "additional_components": [ "Q55FY0", "DDB_G0268544", "Q54IL5", "DDB_G0288655", "Q55FB2", "DDB_G0268544", "Q55FX8", "DDB_G0268544" ] }, "reaction_10626270": { "compartment": "compartment_17957", "id": "reaction_10626270", "reactome": "R-DDI-9632038", "name": "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159160", "species_174384" ], "products": [ "species_159149", "species_158602" ], "modifiers": [ [ "species_10626267", "catalyst" ] ], "additional_components": [ "Q54IL5", "DDB_G0288655" ] }, "reaction_10611928": { "compartment": "compartment_70101", "id": "reaction_10611928", "reactome": "R-DDI-5696213", "name": "AS3MT transfers CH3 from AdoMet to methylarsonite", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696224", "species_71284" ], "products": [ "species_5696211", "species_71285" ], "modifiers": [ [ "species_10611925", "catalyst" ] ], "additional_components": [ "DDB_G0285905" ] }, "reaction_10605451": { "compartment": "compartment_70101", "id": "reaction_10605451", "reactome": "R-DDI-5603114", "name": "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_174390" ], "products": [ "species_111294", "species_29372", "species_71284" ], "modifiers": [ [ "species_10605448", "catalyst" ] ], "additional_components": [ "Q54F07", "DDB_G0291179", "species_29926", "species_74126", "Q54VU3", "DDB_G0280135" ] }, "reaction_10611930": { "compartment": "compartment_70101", "id": "reaction_10611930", "reactome": "R-DDI-5696220", "name": "AS3MT transfers CH3 from AdoMet to arsenite(3-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696216", "species_71284" ], "products": [ "species_71285", "species_5696214" ], "modifiers": [ [ "species_10611925", "catalyst" ] ], "additional_components": [ "DDB_G0285905" ] }, "reaction_10616063": { "compartment": "compartment_70101", "id": "reaction_10616063", "reactome": "R-DDI-6800149", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6806829", "species_71284" ], "products": [ "species_6800127", "species_71285" ], "modifiers": [ [ "species_10616057", "catalyst" ] ], "additional_components": [ "Q54DT3", "DDB_G0292048", "Q54N57", "DDB_G0285489" ] }, "reaction_10623867": { "compartment": "compartment_17963", "id": "reaction_10623867", "reactome": "R-DDI-8953499", "name": "IMPAD1 hydrolyses PAP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742343", "species_2022884" ], "products": [ "species_8851226", "species_8953493" ], "modifiers": [ [ "species_10623864", "catalyst" ], [ "species_8953505", "inhibitor" ] ], "additional_components": [ "species_29926", "Q869K3", "DDB_G0275663" ] }, "reaction_10585754": { "compartment": "compartment_70101", "id": "reaction_10585754", "reactome": "R-DDI-176606", "name": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_158466" ], "products": [ "species_29372", "species_76577" ], "modifiers": [ [ "species_10585751", "catalyst" ] ], "additional_components": [ "DDB_G0275663" ] }, "reaction_10597330": { "compartment": "compartment_70101", "id": "reaction_10597330", "reactome": "R-DDI-1247910", "name": "CNDP2:2Mn2+ dimer hydrolyses CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1247904" ], "products": [ "species_111707", "species_29424" ], "modifiers": [ [ "species_10597327", "catalyst" ] ], "additional_components": [ "species_266099", "Q54X02", "DDB_G0279291" ] }, "reaction_10585509": { "compartment": "compartment_70101", "id": "reaction_10585509", "reactome": "R-DDI-174394", "name": "GSS:Mg2+ dimer synthesizes GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174393", "species_113592", "species_29424" ], "products": [ "species_29372", "species_29370", "species_29450" ], "modifiers": [ [ "species_10585506", "catalyst" ], [ "species_29450", "inhibitor" ] ], "additional_components": [ "Q54E83", "DDB_G0291756", "species_29926" ] }, "reaction_10612601": { "compartment": "compartment_70101", "id": "reaction_10612601", "reactome": "R-DDI-6785928", "name": "CHAC1,2 cleaves GSH to OPRO and CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450" ], "products": [ "species_1247942", "species_1247904" ], "modifiers": [ [ "species_10612598", "catalyst" ] ], "additional_components": [ "Q54LB6", "DDB_G0286727" ] }, "reaction_10597340": { "compartment": "compartment_70101", "id": "reaction_10597340", "reactome": "R-DDI-1247935", "name": "OPLAH hydrolyses OPRO to L-Glu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_1247942" ], "products": [ "species_29372", "species_29404", "species_29370" ], "modifiers": [ [ "species_10597337", "catalyst" ] ], "additional_components": [ "Q54NW6", "DDB_G0284953" ] }, "reaction_10611251": { "compartment": "compartment_70101", "id": "reaction_10611251", "reactome": "R-DDI-5692232", "name": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_5692212" ], "products": [ "species_5692216", "species_29364" ], "modifiers": [ [ "species_10606592", "catalyst" ] ], "additional_components": [ "DDB_G0293850" ] }, "reaction_10585698": { "compartment": "compartment_70101", "id": "reaction_10585698", "reactome": "R-DDI-176054", "name": "GST dimers conjugate GSH with cytosolic substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_176070" ], "products": [ "species_176049" ], "modifiers": [ [ "species_10585695", "catalyst" ] ], "additional_components": [ "species_76396", "CHEBI:34718", "CHEBI:30614", "CHEBI:8927", "CHEBI:32639", "CHEBI:34479", "Q54C73", "DDB_G0293122", "Q86AU1", "DDB_G0274263", "Q556G3", "DDB_G0272632", "Q556P3", "DDB_G0273153", "Q54QV7", "DDB_G0283575", "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "Q54JU2", "DDB_G0287793", "Q54YN2", "DDB_G0278155" ] }, "reaction_10611444": { "compartment": "compartment_17957", "id": "reaction_10611444", "reactome": "R-DDI-5693724", "name": "ESD dimer hydrolyses S-FGSH to GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_5693723" ], "products": [ "species_158543", "species_194712" ], "modifiers": [ [ "species_10611441", "catalyst" ] ], "additional_components": [ "Q54RL8", "DDB_G0283037" ] }, "reaction_10585708": { "compartment": "compartment_17957", "id": "reaction_10585708", "reactome": "R-DDI-176059", "name": "GST trimers transfer GS from GSH to luminal substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158543", "species_176065" ], "products": [ "species_176048" ], "modifiers": [ [ "species_10585705", "catalyst" ] ], "additional_components": [ "species_159211", "CHEBI:27561", "species_76396", "CHEBI:32639", "CHEBI:2505", "CHEBI:35896", "Q54GA9", "DDB_G0290291" ] }, "reaction_10601760": { "compartment": "compartment_5460", "id": "reaction_10601760", "reactome": "R-DDI-2995330", "name": "COX10 transforms heme to heme O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189444", "species_2162257", "species_113521" ], "products": [ "species_2995328", "species_159450" ], "modifiers": [ [ "species_10601757", "catalyst" ] ], "additional_components": [ "DDB_G0288169" ] }, "reaction_10586066": { "compartment": "compartment_70101", "id": "reaction_10586066", "reactome": "R-DDI-189439", "name": "ALAD condenses 2 dALAs to form PBG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189489" ], "products": [ "species_29356", "species_70106", "species_189464" ], "modifiers": [ [ "species_10586063", "catalyst" ] ], "additional_components": [ "species_29426", "Q55E06", "DDB_G0269444" ] }, "reaction_10586084": { "compartment": "compartment_5460", "id": "reaction_10586084", "reactome": "R-DDI-189442", "name": "ALAS condenses SUCC-CoA and Gly to form dALA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_70958", "species_113529" ], "products": [ "species_29374", "species_189466", "species_29376" ], "modifiers": [ [ "species_10586081", "catalyst" ], [ "species_189444", "inhibitor" ] ], "additional_components": [ "Q54UX3", "DDB_G0280763" ] }, "reaction_10586036": { "compartment": "compartment_17927", "id": "reaction_10586036", "reactome": "R-DDI-189421", "name": "CPO transforms COPRO3 to PPGEN9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189461", "species_189411" ], "products": [ "species_189481", "species_189480", "species_189478" ], "modifiers": [ [ "species_10586033", "catalyst" ] ], "additional_components": [ "Q54IA7", "DDB_G0288893" ] }, "reaction_10586102": { "compartment": "compartment_70101", "id": "reaction_10586102", "reactome": "R-DDI-189488", "name": "UROS transforms HMB to URO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189449" ], "products": [ "species_189407", "species_29356" ], "modifiers": [ [ "species_10586099", "catalyst" ] ], "additional_components": [ "DDB_G0285009" ] }, "reaction_10586056": { "compartment": "compartment_70101", "id": "reaction_10586056", "reactome": "R-DDI-189425", "name": "UROD decarboxylates URO3 to COPRO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189407" ], "products": [ "species_189455", "species_113528" ], "modifiers": [ [ "species_10586053", "catalyst" ] ], "additional_components": [ "Q54DF9", "DDB_G0292294" ] }, "reaction_10601768": { "compartment": "compartment_5460", "id": "reaction_10601768", "reactome": "R-DDI-2995334", "name": "COX15 transforms heme O to heme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2995328" ], "products": [ "species_2995348" ], "modifiers": [ [ "species_10601765", "catalyst" ] ], "additional_components": [ "DDB_G0281549" ] }, "reaction_10586106": { "compartment": "compartment_70101", "id": "reaction_10586106", "reactome": "R-DDI-190141", "name": "ALAD binds to Pb2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_190173", "species_10586063" ], "products": [ "species_10586104", "species_29426" ], "modifiers": [], "additional_components": [ "species_29426", "Q55E06", "DDB_G0269444", "species_29426", "Q55E06", "DDB_G0269444", "species_391232" ] }, "reaction_10586108": { "compartment": "compartment_70101", "id": "reaction_10586108", "reactome": "R-DDI-190182", "name": "UROD decarboxylates URO1 to COPRO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_190157" ], "products": [ "species_113528", "species_190128" ], "modifiers": [ [ "species_10586053", "catalyst" ] ], "additional_components": [ "Q54DF9", "DDB_G0292294" ] }, "reaction_10594876": { "compartment": "compartment_876", "id": "reaction_10594876", "reactome": "R-DDI-917979", "name": "ABCG2 tetramer transports heme from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_71185" ], "products": [ "species_29372", "species_917877", "species_29370" ], "modifiers": [ [ "species_10594873", "catalyst" ] ], "additional_components": [ "Q54T02", "DDB_G0282103", "Q8T686", "DDB_G0289655", "Q8T689", "DDB_G0289657", "Q55DA0", "DDB_G0270826", "Q55DW4", "DDB_G0269214", "Q86HQ2", "DDB_G0274117", "Q8T685", "DDB_G0274115" ] }, "reaction_10586046": { "compartment": "compartment_17927", "id": "reaction_10586046", "reactome": "R-DDI-189423", "name": "PPO oxidises PPGEN9 to PRIN9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189461", "species_189478" ], "products": [ "species_189481", "species_189463" ], "modifiers": [ [ "species_10586043", "catalyst" ] ], "additional_components": [ "Q54DT8", "DDB_G0292040", "species_113596" ] }, "reaction_10586094": { "compartment": "compartment_5460", "id": "reaction_10586094", "reactome": "R-DDI-189465", "name": "FECH binds Fe2+ to PRIN9 to form heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189487", "species_113531" ], "products": [ "species_113529", "species_189444" ], "modifiers": [ [ "species_10586091", "catalyst" ], [ "species_391232", "inhibitor" ] ], "additional_components": [ "Q54IA8", "DDB_G0288891" ] }, "reaction_10607713": { "compartment": "compartment_70101", "id": "reaction_10607713", "reactome": "R-DDI-5679041", "name": "ABCC2 transports BMG,BDG from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5679042" ], "products": [ "species_29372", "species_5679034", "species_29370" ], "modifiers": [ [ "species_10597695", "catalyst" ] ], "additional_components": [ "species_159149", "species_159160", "species_159160", "species_159149", "Q54JR2", "DDB_G0287691", "Q54LE6", "DDB_G0286559", "Q54P13", "DDB_G0284867", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977" ] }, "reaction_10627155": { "compartment": "compartment_70101", "id": "reaction_10627155", "reactome": "R-DDI-9663492", "name": "BIL dissociates from GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627153" ], "products": [ "species_189386", "species_10585603" ], "modifiers": [], "additional_components": [ "Q86AU1", "DDB_G0274263", "Q556G3", "DDB_G0272632", "Q556P3", "DDB_G0273153", "Q54QV7", "DDB_G0283575", "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "species_159151", "Q86AU1", "DDB_G0274263", "Q556G3", "DDB_G0272632", "Q556P3", "DDB_G0273153", "Q54QV7", "DDB_G0283575", "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138" ] }, "reaction_10627157": { "compartment": "compartment_70101", "id": "reaction_10627157", "reactome": "R-DDI-9663511", "name": "BIL binds GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189386", "species_10585603" ], "products": [ "species_10627153" ], "modifiers": [], "additional_components": [ "Q86AU1", "DDB_G0274263", "Q556G3", "DDB_G0272632", "Q556P3", "DDB_G0273153", "Q54QV7", "DDB_G0283575", "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "Q86AU1", "DDB_G0274263", "Q556G3", "DDB_G0272632", "Q556P3", "DDB_G0273153", "Q54QV7", "DDB_G0283575", "Q54VI4", "DDB_G0280317", "Q55FF3", "DDB_G0268138", "species_159151" ] }, "reaction_10627151": { "compartment": "compartment_70101", "id": "reaction_10627151", "reactome": "R-DDI-9661417", "name": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5679042" ], "products": [ "species_29372", "species_5679034", "species_29370" ], "modifiers": [ [ "species_10594873", "catalyst" ] ], "additional_components": [ "species_159149", "species_159160", "species_159160", "species_159149", "Q54T02", "DDB_G0282103", "Q8T686", "DDB_G0289655", "Q8T689", "DDB_G0289657", "Q55DA0", "DDB_G0270826", "Q55DW4", "DDB_G0269214", "Q86HQ2", "DDB_G0274117", "Q8T685", "DDB_G0274115" ] }, "reaction_10627148": { "compartment": "compartment_70101", "id": "reaction_10627148", "reactome": "R-DDI-9661405", "name": "ABCC1 transports BIL from cytosol to extracellular region (blood)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189386" ], "products": [ "species_9661418" ], "modifiers": [ [ "species_10589142", "catalyst" ] ], "additional_components": [ "Q54JR2", "DDB_G0287691", "Q54LE6", "DDB_G0286559", "Q8ST87", "DDB_G0280977", "Q54P13", "DDB_G0284867", "Q54U44", "DDB_G0280973" ] }, "reaction_10602853": { "compartment": "compartment_7660", "id": "reaction_10602853", "reactome": "R-DDI-3371582", "name": "HSBP1 binds HSF1 trimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602818", "species_10602849" ], "products": [ "species_10602851" ], "modifiers": [], "additional_components": [ "Q54UC1", "DDB_G0281165", "Q556J3", "DDB_G0272620", "Q556J3", "DDB_G0272620", "Q54UC1", "DDB_G0281165" ] }, "reaction_10605031": { "compartment": "compartment_7660", "id": "reaction_10605031", "reactome": "R-DDI-5324617", "name": "HSP90:FKBP4:PTGES3 binds HSF1 trimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602818", "species_10605027" ], "products": [ "species_10605029" ], "modifiers": [], "additional_components": [ "Q54UC1", "DDB_G0281165", "Q54QI6", "DDB_G0283815", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "Q54QI6", "DDB_G0283815", "Q54UC1", "DDB_G0281165", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042" ] }, "reaction_10592388": { "compartment": "compartment_876", "id": "reaction_10592388", "reactome": "R-DDI-435366", "name": "ZnT1 mediates the efflux of zinc from the cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_158417" ], "modifiers": [ [ "species_10592385", "catalyst" ] ], "additional_components": [ "DDB_G0282067" ] }, "reaction_10592414": { "compartment": "compartment_70101", "id": "reaction_10592414", "reactome": "R-DDI-437162", "name": "PI3K alpha, beta, gamma convert PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10590600", "catalyst" ] ], "additional_components": [ "Q54DK0", "DDB_G0292252", "P54675", "DDB_G0275011", "P54673", "DDB_G0278727", "Q54S78", "DDB_G0282625", "Q55FX5", "DDB_G0282625", "P54674", "DDB_G0283081" ] }, "reaction_10581592": { "compartment": "compartment_13231", "id": "reaction_10581592", "reactome": "R-DDI-75823", "name": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581584" ], "products": [ "species_10581590" ], "modifiers": [], "additional_components": [ "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439" ] }, "reaction_10581596": { "compartment": "compartment_70101", "id": "reaction_10581596", "reactome": "R-DDI-75825", "name": "Proteasome mediated degradation of Cyclin D1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581594" ], "products": [ "species_10577037" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10622096": { "compartment": "compartment_171062", "id": "reaction_10622096", "reactome": "R-DDI-8875320", "name": "RAB5 GEFs exchange GTP for GDP on RAB5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10622017" ], "products": [ "species_10621999", "species_29420", "species_10622025" ], "modifiers": [ [ "species_10622093", "catalyst" ] ], "additional_components": [ "Q86JP3", "DDB_G0271984", "species_29420", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q86JP3", "DDB_G0271984", "species_29438", "Q54NU1", "DDB_G0291115", "Q54W41", "DDB_G0291115", "Q54VS5", "DDB_G0291115", "Q55AI4", "DDB_G0291115", "Q55AA6", "DDB_G0291115", "Q54F48", "DDB_G0291115", "Q54HF9", "DDB_G0291115" ] }, "reaction_10622352": { "compartment": "compartment_70101", "id": "reaction_10622352", "reactome": "R-DDI-8876616", "name": "DENND6A,B exchange GTP for GDP on RAB14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10622336" ], "products": [ "species_10621999", "species_29420", "species_10622340" ], "modifiers": [ [ "species_10622349", "catalyst" ] ], "additional_components": [ "species_29420", "P36410", "DDB_G0281337", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "P36410", "DDB_G0281337", "species_29438", "Q54VA9", "DDB_G0280481" ] }, "reaction_10622528": { "compartment": "compartment_171062", "id": "reaction_10622528", "reactome": "R-DDI-8877311", "name": "RAB31 GEFs exchange GTP for GDP on RAB31", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10622519" ], "products": [ "species_10621999", "species_29420", "species_10622523" ], "modifiers": [ [ "species_10622525", "catalyst" ] ], "additional_components": [ "species_29420", "Q8MYF2", "DDB_G0277441", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q8MYF2", "DDB_G0277441", "species_29438", "Q54W41", "DDB_G0291115", "Q54VS5", "DDB_G0291115", "Q55AI4", "DDB_G0291115", "Q55AA6", "DDB_G0291115", "Q54F48", "DDB_G0291115", "Q54NU1", "DDB_G0291115", "Q54HF9", "DDB_G0291115" ] }, "reaction_10622752": { "compartment": "compartment_12045", "id": "reaction_10622752", "reactome": "R-DDI-8877998", "name": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10622739" ], "products": [ "species_10621999", "species_29420", "species_10622743" ], "modifiers": [ [ "species_10622749", "catalyst" ] ], "additional_components": [ "Q54GY8", "DDB_G0289827", "species_29420", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54GY8", "DDB_G0289827", "species_29438", "Q54UJ4", "DDB_G0281043", "Q54DM6", "DDB_G0292124" ] }, "reaction_10622646": { "compartment": "compartment_13946", "id": "reaction_10622646", "reactome": "R-DDI-8877475", "name": "TRAPPC complexes exchange GTP for GDP on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10622591" ], "products": [ "species_10621999", "species_29420", "species_10622619" ], "modifiers": [ [ "species_10622643", "catalyst" ] ], "additional_components": [ "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "P34139", "DDB_G0283757", "species_29420", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "P34139", "DDB_G0283757", "species_29438", "Q54TK7", "DDB_G0281693", "Q54KR2", "DDB_G0287157", "Q54RV6", "DDB_G0282887", "Q54CU7", "DDB_G0292690", "Q54U24", "DDB_G0281351", "Q55EX6", "DDB_G0269062", "Q86K94", "DDB_G0277135", "Q54CV2", "DDB_G0292682", "Q54UU1", "DDB_G0280827", "Q54YG5", "DDB_G0278643", "Q557G3", "DDB_G0273467", "Q555X3", "DDB_G0274803", "Q556Z3", "DDB_G0273209" ] }, "reaction_10622583": { "compartment": "compartment_17938", "id": "reaction_10622583", "reactome": "R-DDI-8877451", "name": "MON1:CCZ1 exchanges GTP for GDP on RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10622534" ], "products": [ "species_10621999", "species_29420", "species_10622564" ], "modifiers": [ [ "species_10622580", "catalyst" ] ], "additional_components": [ "P36411", "DDB_G0269236", "species_29420", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "P36411", "DDB_G0269236", "species_29438", "Q54TG0", "DDB_G0281773", "Q54IQ5", "DDB_G0288589" ] }, "reaction_10622247": { "compartment": "compartment_263163", "id": "reaction_10622247", "reactome": "R-DDI-8876191", "name": "RAB9 GEFs exchange GTP for GDP on RAB9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10622164" ], "products": [ "species_10621999", "species_29420", "species_10622216" ], "modifiers": [ [ "species_10622244", "catalyst" ] ], "additional_components": [ "Q1ZXB9", "DDB_G0290831", "Q54FK7", "DDB_G0290779", "P36411", "DDB_G0269236", "Q54FK2", "DDB_G0290793", "Q54FK8", "DDB_G0290829", "Q1ZXB7", "DDB_G0290791", "Q54FK4", "DDB_G0290833", "Q54K69", "DDB_G0287553", "Q1ZXB8", "DDB_G0294571", "Q54FK5", "DDB_G0290789", "Q552H0", "DDB_G0294571", "species_29420", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54FK5", "DDB_G0290789", "Q54FK4", "DDB_G0290833", "P36411", "DDB_G0269236", "Q54FK8", "DDB_G0290829", "Q54FK7", "DDB_G0290779", "Q1ZXB8", "DDB_G0294571", "Q552H0", "DDB_G0294571", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "Q54FK2", "DDB_G0290793", "Q1ZXB9", "DDB_G0290831", "species_29438", "Q55DD7", "DDB_G0270918" ] }, "reaction_10622260": { "compartment": "compartment_263163", "id": "reaction_10622260", "reactome": "R-DDI-8876193", "name": "RIC1-RGP1 exchanges GTP for GDP on RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10622251" ], "products": [ "species_10621999", "species_29420", "species_10622257" ], "modifiers": [ [ "species_10618445", "catalyst" ] ], "additional_components": [ "species_29420", "Q55FK2", "DDB_G0268068", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "species_29438", "Q55FK2", "DDB_G0268068", "Q54WR7", "DDB_G0279477", "Q76NU4", "DDB_G0277397" ] }, "reaction_10622709": { "compartment": "compartment_5668575", "id": "reaction_10622709", "reactome": "R-DDI-8877760", "name": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10622680" ], "products": [ "species_10621999", "species_29420", "species_10622694" ], "modifiers": [ [ "species_10622706", "catalyst" ] ], "additional_components": [ "Q54QR3", "DDB_G0283603", "Q8MXQ2", "DDB_G0275675", "Q1ZXC0", "DDB_G0290827", "species_29420", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q8MXQ2", "DDB_G0275675", "Q54QR3", "DDB_G0283603", "Q1ZXC0", "DDB_G0290827", "species_29438", "Q55FG6", "DDB_G0268126", "Q54M79", "DDB_G0286137" ] }, "reaction_10622442": { "compartment": "compartment_171062", "id": "reaction_10622442", "reactome": "R-DDI-8876837", "name": "RAB21 GEFs exchange GTP for GDP on RAB21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10622376" ], "products": [ "species_10622380", "species_10621999", "species_29420" ], "modifiers": [ [ "species_10622439", "catalyst" ] ], "additional_components": [ "P34142", "DDB_G0286553", "species_29420", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "P34142", "DDB_G0286553", "species_29438", "Q54VT9", "DDB_G0280143", "Q55FM7", "DDB_G0268034", "Q54PZ6", "DDB_G0284213", "Q54PL3", "DDB_G0293258", "Q55EE1", "DDB_G0293258", "Q54GQ1", "DDB_G0293258", "Q55E58", "DDB_G0269250", "Q54TD5", "DDB_G0293258", "Q54PT8", "DDB_G0293258", "Q55AZ2", "DDB_G0293258", "Q54YC2", "DDB_G0293258", "Q54C52", "DDB_G0293258", "Q55E04", "DDB_G0293258", "Q1ZXD2", "DDB_G0293258", "Q55BL7", "DDB_G0293258" ] }, "reaction_10624461": { "compartment": "compartment_5460", "id": "reaction_10624461", "reactome": "R-DDI-8986181", "name": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624453" ], "products": [], "modifiers": [ [ "species_10624458", "catalyst" ] ], "additional_components": [ "Q54QH7", "DDB_G0283889", "DDB_G0271506" ] }, "reaction_10577280": { "compartment": "compartment_7660", "id": "reaction_10577280", "reactome": "R-DDI-69006", "name": "Phosphorylated Cdc6 is exported from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577255" ], "products": [ "species_10577278" ], "modifiers": [], "additional_components": [ "DDB_G0275983", "DDB_G0275983" ] }, "reaction_10577387": { "compartment": "compartment_70101", "id": "reaction_10577387", "reactome": "R-DDI-69015", "name": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577278", "species_10577037", "species_113592" ], "products": [ "species_10577284" ], "modifiers": [ [ "species_10577384", "catalyst" ] ], "additional_components": [ "DDB_G0275983", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q552L8", "DDB_G0275983", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54XS6", "DDB_G0278775", "Q54VV5", "DDB_G0280113", "Q1ZXE6", "DDB_G0286233", "Q54NC6", "DDB_G0285349", "Q54YA9", "DDB_G0278327", "Q55ER5", "DDB_G0268992", "Q86B11", "DDB_G0272775", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q551S9", "DDB_G0276377", "Q54C30", "DDB_G0293230", "Q54L48", "DDB_G0286909", "Q54J83", "DDB_G0288223", "Q54TE1", "DDB_G0281833", "Q54NI1", "DDB_G0285223", "Q54I43", "DDB_G0289021", "Q54KM3", "DDB_G0287259" ] }, "reaction_10577389": { "compartment": "compartment_70101", "id": "reaction_10577389", "reactome": "R-DDI-69016", "name": "Ubiquitinated Cdc6 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577284" ], "products": [ "species_10577037" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q552L8", "DDB_G0275983", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10577276": { "compartment": "compartment_7660", "id": "reaction_10577276", "reactome": "R-DDI-69005", "name": "Cdc6 protein is phosphorylated by CDK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10576515" ], "products": [ "species_113582", "species_10577255" ], "modifiers": [ [ "species_10577273", "catalyst" ] ], "additional_components": [ "DDB_G0275983", "DDB_G0275983", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493" ] }, "reaction_10577393": { "compartment": "compartment_7660", "id": "reaction_10577393", "reactome": "R-DDI-69019", "name": "Mcm4,6,7 trimer forms and associates with the replication fork", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576576" ], "products": [ "species_10576574", "species_10577391", "species_10576559", "species_10576549" ], "modifiers": [], "additional_components": [ "Q54VI9", "DDB_G0280309", "Q86B14", "DDB_G0272760", "Q54RU0", "DDB_G0282933", "Q86IF1", "DDB_G0275623", "Q54CP4", "DDB_G0292958", "Q54LI2", "DDB_G0286623", "DDB_G0286623", "Q86B14", "DDB_G0272760", "Q54RU0", "DDB_G0282933", "Q86IF1", "DDB_G0275623", "DDB_G0292958", "DDB_G0280309" ] }, "reaction_10576897": { "compartment": "compartment_7660", "id": "reaction_10576897", "reactome": "R-DDI-68946", "name": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576678", "species_10576865" ], "products": [ "species_10576868" ], "modifiers": [ [ "species_10576894", "catalyst" ] ], "additional_components": [ "DDB_G0283073", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0283073", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54K33", "DDB_G0287629" ] }, "reaction_10576901": { "compartment": "compartment_7660", "id": "reaction_10576901", "reactome": "R-DDI-68947", "name": "Ubiquitinated Orc1 enters the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576868" ], "products": [ "species_10576899" ], "modifiers": [], "additional_components": [ "DDB_G0283073", "DDB_G0283073" ] }, "reaction_10576708": { "compartment": "compartment_7660", "id": "reaction_10576708", "reactome": "R-DDI-68944", "name": "Orc1 is phosphorylated by cyclin A/CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10576578" ], "products": [ "species_113582", "species_10576680", "species_10576678" ], "modifiers": [ [ "species_10576705", "catalyst" ] ], "additional_components": [ "Q552L8", "DDB_G0275983", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q54RN8", "DDB_G0283009", "Q86AD6", "DDB_G0271562", "Q54P62", "DDB_G0284771", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "Q54VI9", "DDB_G0280309", "Q86B14", "DDB_G0272760", "Q54RU0", "DDB_G0282933", "Q86IF1", "DDB_G0275623", "Q54CP4", "DDB_G0292958", "Q54LI2", "DDB_G0286623", "Q54VI9", "DDB_G0280309", "Q86B14", "DDB_G0272760", "Q54RU0", "DDB_G0282933", "Q86IF1", "DDB_G0275623", "Q54CP4", "DDB_G0292958", "Q54LI2", "DDB_G0286623", "Q552L8", "DDB_G0275983", "Q55CU7", "DDB_G0269894", "Q54RN8", "DDB_G0283009", "Q86AD6", "DDB_G0271562", "Q54P62", "DDB_G0284771", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "DDB_G0283073", "P34112", "DDB_G0272813" ] }, "reaction_10577243": { "compartment": "compartment_70101", "id": "reaction_10577243", "reactome": "R-DDI-68948", "name": "Ubiquitinated Orc1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576899" ], "products": [ "species_10577037" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "DDB_G0283073", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10585789": { "compartment": "compartment_7660", "id": "reaction_10585789", "reactome": "R-DDI-176956", "name": "Formation of GINS complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585775", "species_10585770", "species_10585785", "species_10585780" ], "products": [ "species_10585787" ], "modifiers": [], "additional_components": [ "DDB_G0293564", "DDB_G0289271", "DDB_G0269324", "DDB_G0291506", "Q54EH6", "DDB_G0291506", "Q55EA2", "DDB_G0269324", "Q54HR6", "DDB_G0289271", "Q54BL9", "DDB_G0293564" ] }, "reaction_10577248": { "compartment": "compartment_7660", "id": "reaction_10577248", "reactome": "R-DDI-68950", "name": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30187", "species_10576632", "species_30185", "species_29892", "species_29604" ], "products": [ "species_10577245" ], "modifiers": [ [ "species_10576604", "catalyst" ] ], "additional_components": [ "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731" ] }, "reaction_10576635": { "compartment": "compartment_7660", "id": "reaction_10576635", "reactome": "R-DDI-68913", "name": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576630", "species_30595" ], "products": [ "species_10576632", "species_10576626" ], "modifiers": [ [ "species_10576630", "catalyst" ] ], "additional_components": [ "Q54RD4", "DDB_G0283189", "Q7KWN0", "DDB_G0272740", "Q54Y85", "DDB_G0278367", "Q75JQ9", "DDB_G0272222", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "species_110614", "species_113592", "species_29494", "species_29438", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54RD4", "DDB_G0283189", "Q7KWN0", "DDB_G0272740", "Q54Y85", "DDB_G0278367", "Q75JQ9", "DDB_G0272222", "Q54RD4", "DDB_G0283189", "Q7KWN0", "DDB_G0272740", "Q54Y85", "DDB_G0278367", "Q75JQ9", "DDB_G0272222", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731" ] }, "reaction_10576580": { "compartment": "compartment_7660", "id": "reaction_10576580", "reactome": "R-DDI-68849", "name": "Mcm2-7 associates with the Cdt1:CDC6:ORC:origin complex, forming the pre-replicative complex (preRC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576576", "species_10576544" ], "products": [ "species_10576578" ], "modifiers": [], "additional_components": [ "Q54VI9", "DDB_G0280309", "Q86B14", "DDB_G0272760", "Q54RU0", "DDB_G0282933", "Q86IF1", "DDB_G0275623", "Q54CP4", "DDB_G0292958", "Q54LI2", "DDB_G0286623", "Q552L8", "DDB_G0275983", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q54RN8", "DDB_G0283009", "Q86AD6", "DDB_G0271562", "Q54P62", "DDB_G0284771", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "Q552L8", "DDB_G0275983", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q54RN8", "DDB_G0283009", "Q86AD6", "DDB_G0271562", "Q54P62", "DDB_G0284771", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "Q54VI9", "DDB_G0280309", "Q86B14", "DDB_G0272760", "Q54RU0", "DDB_G0282933", "Q86IF1", "DDB_G0275623", "Q54CP4", "DDB_G0292958", "Q54LI2", "DDB_G0286623" ] }, "reaction_10585791": { "compartment": "compartment_7660", "id": "reaction_10585791", "reactome": "R-DDI-176973", "name": "Association of MCM8 with ORC:origin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576508", "species_10576532" ], "products": [ "species_10576536" ], "modifiers": [], "additional_components": [ "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q86AD6", "DDB_G0271562", "Q54P62", "DDB_G0284771", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "DDB_G0283009", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q54RN8", "DDB_G0283009", "Q86AD6", "DDB_G0271562", "Q54P62", "DDB_G0284771", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214" ] }, "reaction_10576540": { "compartment": "compartment_7660", "id": "reaction_10576540", "reactome": "R-DDI-68688", "name": "CDC6 association with ORC:origin complexes mediated by MCM8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576536", "species_10576515" ], "products": [ "species_10576538" ], "modifiers": [], "additional_components": [ "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q54RN8", "DDB_G0283009", "Q86AD6", "DDB_G0271562", "Q54P62", "DDB_G0284771", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "DDB_G0275983", "Q552L8", "DDB_G0275983", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q54RN8", "DDB_G0283009", "Q86AD6", "DDB_G0271562", "Q54P62", "DDB_G0284771", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214" ] }, "reaction_10576526": { "compartment": "compartment_7660", "id": "reaction_10576526", "reactome": "R-DDI-68637", "name": "CDC6 protein is synthesized under the control of E2F transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10576515" ], "modifiers": [ [ "species_10576524", "catalyst" ] ], "additional_components": [ "DDB_G0275983", "Q54Q23", "DDB_G0284129" ] }, "reaction_10576672": { "compartment": "compartment_7660", "id": "reaction_10576672", "reactome": "R-DDI-68917", "name": "Cdc45 associates with the pre-replicative complex at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576668", "species_10576642" ], "products": [ "species_10576670" ], "modifiers": [], "additional_components": [ "Q54DK3", "DDB_G0292152", "P34112", "DDB_G0272813", "Q54VI9", "DDB_G0280309", "Q86B14", "DDB_G0272760", "Q54RU0", "DDB_G0282933", "Q86IF1", "DDB_G0275623", "Q54CP4", "DDB_G0292958", "Q54LI2", "DDB_G0286623", "Q552L8", "DDB_G0275983", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q54RN8", "DDB_G0283009", "Q86AD6", "DDB_G0271562", "Q54P62", "DDB_G0284771", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214", "DDB_G0267748", "Q55GA4", "DDB_G0267748", "Q54DK3", "DDB_G0292152", "P34112", "DDB_G0272813", "Q54VI9", "DDB_G0280309", "Q86B14", "DDB_G0272760", "Q54RU0", "DDB_G0282933", "Q86IF1", "DDB_G0275623", "Q54CP4", "DDB_G0292958", "Q54LI2", "DDB_G0286623", "Q552L8", "DDB_G0275983", "Q54RM2", "DDB_G0283073", "Q55CU7", "DDB_G0269894", "Q54RN8", "DDB_G0283009", "Q86AD6", "DDB_G0271562", "Q54P62", "DDB_G0284771", "Q55BR6", "DDB_G0271078", "Q54C22", "DDB_G0293214" ] }, "reaction_10577252": { "compartment": "compartment_7660", "id": "reaction_10577252", "reactome": "R-DDI-68960", "name": "DNA polymerase epsilon binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576626", "species_68419" ], "products": [ "species_10576628" ], "modifiers": [], "additional_components": [ "Q54RD4", "DDB_G0283189", "Q7KWN0", "DDB_G0272740", "Q54Y85", "DDB_G0278367", "Q75JQ9", "DDB_G0272222", "Q54RD4", "DDB_G0283189", "Q7KWN0", "DDB_G0272740", "Q54Y85", "DDB_G0278367", "Q75JQ9", "DDB_G0272222" ] }, "reaction_10576637": { "compartment": "compartment_7660", "id": "reaction_10576637", "reactome": "R-DDI-68914", "name": "DNA polymerase alpha:primase binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576604", "species_10576628" ], "products": [ "species_10576630" ], "modifiers": [], "additional_components": [ "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54RD4", "DDB_G0283189", "Q7KWN0", "DDB_G0272740", "Q54Y85", "DDB_G0278367", "Q75JQ9", "DDB_G0272222", "Q54RD4", "DDB_G0283189", "Q7KWN0", "DDB_G0272740", "Q54Y85", "DDB_G0278367", "Q75JQ9", "DDB_G0272222", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731" ] }, "reaction_10589187": { "compartment": "compartment_7660", "id": "reaction_10589187", "reactome": "R-DDI-266204", "name": "Association of HMGB1/HMGB2 with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589181", "species_29428" ], "products": [ "species_10589185" ], "modifiers": [], "additional_components": [ "DDB_G0270260", "Q55C24", "DDB_G0270260" ] }, "reaction_10589444": { "compartment": "compartment_70101", "id": "reaction_10589444", "reactome": "R-DDI-351948", "name": "Mitochondrial recruitment of Drp1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589436" ], "products": [ "species_10589442" ], "modifiers": [ [ "species_10589400", "catalyst" ] ], "additional_components": [ "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "DDB_G0287543" ] }, "reaction_10589430": { "compartment": "compartment_13231", "id": "reaction_10589430", "reactome": "R-DDI-351947", "name": "Nuclear translocation of catalytic domain of Mst3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589416" ], "products": [ "species_10589428" ], "modifiers": [], "additional_components": [ "O61122", "DDB_G0286359", "Q54DC8", "DDB_G0292350", "O61122", "DDB_G0286359", "Q54DC8", "DDB_G0292350" ] }, "reaction_10601347": { "compartment": "compartment_70101", "id": "reaction_10601347", "reactome": "R-DDI-2529020", "name": "CK2 phosphorylates condensin I subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10601313" ], "products": [ "species_29370", "species_10601303" ], "modifiers": [ [ "species_10601344", "catalyst" ] ], "additional_components": [ "Q54PK4", "DDB_G0284499", "Q54B17", "DDB_G0293984", "Q54DR4", "DDB_G0292066", "Q54WY1", "DDB_G0279329", "Q54LV0", "DDB_G0286403", "Q54DR4", "DDB_G0292066", "Q54LV0", "DDB_G0286403", "Q54PK4", "DDB_G0284499", "Q54B17", "DDB_G0293984", "Q54WY1", "DDB_G0279329", "Q54PF1", "DDB_G0284601", "Q02720", "DDB_G0276885", "Q54LR6", "DDB_G0286481" ] }, "reaction_10601315": { "compartment": "compartment_70101", "id": "reaction_10601315", "reactome": "R-DDI-2529015", "name": "Dephosphorylation of CK2-modified condensin I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10601303" ], "products": [ "species_29372", "species_10601313" ], "modifiers": [ [ "species_2529006", "catalyst" ] ], "additional_components": [ "Q54DR4", "DDB_G0292066", "Q54LV0", "DDB_G0286403", "Q54PK4", "DDB_G0284499", "Q54B17", "DDB_G0293984", "Q54WY1", "DDB_G0279329", "Q54PK4", "DDB_G0284499", "Q54B17", "DDB_G0293984", "Q54DR4", "DDB_G0292066", "Q54WY1", "DDB_G0279329", "Q54LV0", "DDB_G0286403" ] }, "reaction_10605458": { "compartment": "compartment_876", "id": "reaction_10605458", "reactome": "R-DDI-5610727", "name": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_111294", "species_30389" ], "modifiers": [ [ "species_10605455", "catalyst" ] ], "additional_components": [ "species_29926" ] }, "reaction_10605510": { "compartment": "compartment_5263228", "id": "reaction_10605510", "reactome": "R-DDI-5610733", "name": "KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605506", "species_10605504" ], "products": [ "species_10605508" ], "modifiers": [], "additional_components": [ "DDB_G0284471", "species_29420", "species_29438", "species_29420", "species_29438", "Q6S003", "DDB_G0284471" ] }, "reaction_10605534": { "compartment": "compartment_5263232", "id": "reaction_10605534", "reactome": "R-DDI-5610749", "name": "cAMP dissociates PKA, promoting GLI processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605530", "species_30389" ], "products": [ "species_10605518", "species_10605532" ], "modifiers": [], "additional_components": [ "P05987", "DDB_G0279413", "Q8MM62", "DDB_G0276027", "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029", "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029", "species_30389", "P05987", "DDB_G0279413", "Q8MM62", "DDB_G0276027" ] }, "reaction_10580620": { "compartment": "compartment_7660", "id": "reaction_10580620", "reactome": "R-DDI-73757", "name": "Binding of RRN3 to RNA Polymerase I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580616", "species_10580611" ], "products": [ "species_10580618" ], "modifiers": [], "additional_components": [ "DDB_G0289587", "Q54YF5", "DDB_G0278263", "Q54R66", "DDB_G0283365", "Q54EH2", "DDB_G0291636", "Q54BM1", "DDB_G0293560", "Q54SN4", "DDB_G0282339", "Q54FA8", "DDB_G0291037", "Q55AB6", "DDB_G0272036", "Q86H36", "DDB_G0275759", "Q54FE8", "DDB_G0290909", "Q54YW8", "DDB_G0278039", "Q55FA4", "DDB_G0268198", "Q54YF5", "DDB_G0278263", "Q54R66", "DDB_G0283365", "Q54EH2", "DDB_G0291636", "Q54BM1", "DDB_G0293560", "Q54SN4", "DDB_G0282339", "Q54FA8", "DDB_G0291037", "Q55AB6", "DDB_G0272036", "Q86H36", "DDB_G0275759", "Q54FE8", "DDB_G0290909", "Q54YW8", "DDB_G0278039", "Q55FA4", "DDB_G0268198", "Q54HB0", "DDB_G0289587" ] }, "reaction_10581489": { "compartment": "compartment_350", "id": "reaction_10581489", "reactome": "R-DDI-74986", "name": "Elongation of pre-rRNA transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74985", "species_30595" ], "products": [ "species_74985" ], "modifiers": [ [ "species_10580705", "catalyst" ], [ "species_10581487", "catalyst" ] ], "additional_components": [ "species_110614", "species_113592", "species_29494", "species_29438", "Q54YF5", "DDB_G0278263", "Q54R66", "DDB_G0283365", "Q54EH2", "DDB_G0291636", "Q54BM1", "DDB_G0293560", "Q54SN4", "DDB_G0282339", "Q54FA8", "DDB_G0291037", "Q55AB6", "DDB_G0272036", "Q86H36", "DDB_G0275759", "Q54FE8", "DDB_G0290909", "Q54YW8", "DDB_G0278039", "Q55FA4", "DDB_G0268198", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q554V6", "DDB_G0274953", "P26355", "DDB_G0275617", "Q55C69", "DDB_G0270198", "Q54RN0", "DDB_G0283023", "Q54RQ4", "DDB_G0283023", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863" ] }, "reaction_10580707": { "compartment": "compartment_7660", "id": "reaction_10580707", "reactome": "R-DDI-73769", "name": "Loss of Rrn3 from RNA Polymerase I promoter escape complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580701" ], "products": [ "species_10580616", "species_10580705" ], "modifiers": [], "additional_components": [ "Q554V6", "DDB_G0274953", "P26355", "DDB_G0275617", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54YF5", "DDB_G0278263", "Q54R66", "DDB_G0283365", "Q54EH2", "DDB_G0291636", "Q54BM1", "DDB_G0293560", "Q54SN4", "DDB_G0282339", "Q54FA8", "DDB_G0291037", "Q55AB6", "DDB_G0272036", "Q86H36", "DDB_G0275759", "Q54FE8", "DDB_G0290909", "Q54YW8", "DDB_G0278039", "Q55FA4", "DDB_G0268198", "Q54HB0", "DDB_G0289587", "DDB_G0289587", "Q54YF5", "DDB_G0278263", "Q54R66", "DDB_G0283365", "Q54EH2", "DDB_G0291636", "Q54BM1", "DDB_G0293560", "Q54SN4", "DDB_G0282339", "Q54FA8", "DDB_G0291037", "Q55AB6", "DDB_G0272036", "Q86H36", "DDB_G0275759", "Q54FE8", "DDB_G0290909", "Q54YW8", "DDB_G0278039", "Q55FA4", "DDB_G0268198", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q554V6", "DDB_G0274953", "P26355", "DDB_G0275617" ] }, "reaction_10590390": { "compartment": "compartment_70101", "id": "reaction_10590390", "reactome": "R-DDI-389788", "name": "Activation of PAKs by RAC1 and CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583374", "species_10590384" ], "products": [ "species_10590388", "species_10590386" ], "modifiers": [], "additional_components": [ "P34144", "DDB_G0277869", "species_29438", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459", "P34144", "DDB_G0277869", "species_29438", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459" ] }, "reaction_10592081": { "compartment": "compartment_70101", "id": "reaction_10592081", "reactome": "R-DDI-432232", "name": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10592069" ], "products": [ "species_10592079", "species_29370" ], "modifiers": [ [ "species_10582991", "catalyst" ] ], "additional_components": [ "Q9U8P7", "DDB_G0267378", "Q54FQ9", "DDB_G0290691", "Q54V53", "DDB_G0280537", "Q54FQ9", "DDB_G0290691", "Q54V53", "DDB_G0280537", "Q9U8P7", "DDB_G0267378", "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029" ] }, "reaction_10592022": { "compartment": "compartment_876", "id": "reaction_10592022", "reactome": "R-DDI-432010", "name": "Aquaporin-1 passively transports water into cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10592019", "catalyst" ] ], "additional_components": [ "Q9U8P7", "DDB_G0267378" ] }, "reaction_10592024": { "compartment": "compartment_876", "id": "reaction_10592024", "reactome": "R-DDI-432054", "name": "Aquaporin-1 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10592019", "catalyst" ] ], "additional_components": [ "Q9U8P7", "DDB_G0267378" ] }, "reaction_10592059": { "compartment": "compartment_876", "id": "reaction_10592059", "reactome": "R-DDI-432067", "name": "Aquaporin-4 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10592056", "catalyst" ] ], "additional_components": [ "Q54FQ9", "DDB_G0290691", "Q54V53", "DDB_G0280537", "Q9U8P7", "DDB_G0267378" ] }, "reaction_10592046": { "compartment": "compartment_876", "id": "reaction_10592046", "reactome": "R-DDI-432065", "name": "p-S256-Aquaporin-2 passively transports water into cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10592043", "catalyst" ] ], "additional_components": [ "Q54V53", "DDB_G0280537", "Q9U8P7", "DDB_G0267378", "Q54FQ9", "DDB_G0290691" ] }, "reaction_10625623": { "compartment": "compartment_70101", "id": "reaction_10625623", "reactome": "R-DDI-9029987", "name": "p-S216-CDC25C translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581495" ], "products": [ "species_10581499" ], "modifiers": [], "additional_components": [ "DDB_G0283617", "DDB_G0283617" ] }, "reaction_10581576": { "compartment": "compartment_7660", "id": "reaction_10581576", "reactome": "R-DDI-75809", "name": "Phosphorylation of Cdc25C at Ser216 by CHEK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10581492" ], "products": [ "species_113582", "species_10581495" ], "modifiers": [ [ "species_10577617", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "DDB_G0280321" ] }, "reaction_10608080": { "compartment": "compartment_7660", "id": "reaction_10608080", "reactome": "R-DDI-5683774", "name": "p-T68-CHEK2 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608076" ], "products": [ "species_10608078" ], "modifiers": [], "additional_components": [ "DDB_G0280321", "Q54VI1", "DDB_G0280321" ] }, "reaction_10608083": { "compartment": "compartment_7660", "id": "reaction_10608083", "reactome": "R-DDI-5683792", "name": "p-T68-CHEK2 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608078", "species_29358" ], "products": [ "species_113582", "species_10577617" ], "modifiers": [ [ "species_10608078", "catalyst" ] ], "additional_components": [ "Q54VI1", "DDB_G0280321", "DDB_G0280321", "Q54VI1", "DDB_G0280321" ] }, "reaction_10581497": { "compartment": "compartment_7660", "id": "reaction_10581497", "reactome": "R-DDI-75010", "name": "Phosphorylation of Cdc25C at Ser 216 by Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10581492" ], "products": [ "species_113582", "species_10581495" ], "modifiers": [ [ "species_10577605", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "DDB_G0279719" ] }, "reaction_10601585": { "compartment": "compartment_70101", "id": "reaction_10601585", "reactome": "R-DDI-2730872", "name": "Activation of Calcineurin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10599837", "species_10583042", "species_74016" ], "products": [ "species_10601542" ], "modifiers": [], "additional_components": [ "Q55G87", "DDB_G0267446", "species_29426", "Q7YSW8", "DDB_G0276883", "CHEBI:29034", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "species_74112", "Q55G87", "DDB_G0267446", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "species_29426", "Q7YSW8", "DDB_G0276883", "CHEBI:29034" ] }, "reaction_10601566": { "compartment": "compartment_70101", "id": "reaction_10601566", "reactome": "R-DDI-2730867", "name": "Translocation of CaN:CaM:NFAT to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601546" ], "products": [ "species_10601564" ], "modifiers": [], "additional_components": [ "species_74112", "Q55G87", "DDB_G0267446", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "species_29426", "Q7YSW8", "DDB_G0276883", "CHEBI:29034", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "species_74112", "Q7YSW8", "DDB_G0276883", "CHEBI:29034", "species_29426", "Q55G87", "DDB_G0267446" ] }, "reaction_10605809": { "compartment": "compartment_876", "id": "reaction_10605809", "reactome": "R-DDI-5624494", "name": "RAF1 binds p21 RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590651", "species_10585144" ], "products": [ "species_10605804" ], "modifiers": [], "additional_components": [ "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54TM7", "DDB_G0281557" ] }, "reaction_10605807": { "compartment": "compartment_876", "id": "reaction_10605807", "reactome": "R-DDI-5624492", "name": "PAK phosphorylates p21 RAF1 on S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605804", "species_113592" ], "products": [ "species_29370", "species_10605796" ], "modifiers": [ [ "species_10590386", "catalyst" ] ], "additional_components": [ "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54TM7", "DDB_G0281557", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q869N2", "DDB_G0276459" ] }, "reaction_10605769": { "compartment": "compartment_70101", "id": "reaction_10605769", "reactome": "R-DDI-5618331", "name": "HDAC6 deacetylates microtubules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10605766", "species_76194" ], "products": [ "species_10589898", "species_76183" ], "modifiers": [ [ "species_10605033", "catalyst" ] ], "additional_components": [ "species_29438", "species_29420", "species_29438", "species_29420", "DDB_G0279267" ] }, "reaction_10608705": { "compartment": "compartment_5460", "id": "reaction_10608705", "reactome": "R-DDI-5688289", "name": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_10608691" ], "products": [ "species_5688337", "species_10608695", "species_5688274" ], "modifiers": [ [ "species_10608702", "catalyst" ] ], "additional_components": [ "Q55BJ9", "DDB_G0271106", "Q54Z60", "DDB_G0277815", "Q54KB7", "DDB_G0287469", "Q54KB7", "DDB_G0287469", "Q54Z60", "DDB_G0277815", "Q55BJ9", "DDB_G0271106", "Q54LF0", "DDB_G0286671", "species_29426" ] }, "reaction_10608718": { "compartment": "compartment_17927", "id": "reaction_10608718", "reactome": "R-DDI-5688294", "name": "SIRT5 deacetylates Cytochrome C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5688282", "species_10608708" ], "products": [ "species_5688281", "species_10583365", "species_5688340" ], "modifiers": [ [ "species_10608715", "catalyst" ] ], "additional_components": [ "DDB_G0275537", "DDB_G0275537", "species_29426", "Q55DB0", "DDB_G0270928" ] }, "reaction_10624307": { "compartment": "compartment_876", "id": "reaction_10624307", "reactome": "R-DDI-8982019", "name": "Active G alpha (i)i1/i2/i3 binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584927", "species_10624289" ], "products": [ "species_10624305" ], "modifiers": [], "additional_components": [ "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438" ] }, "reaction_10585810": { "compartment": "compartment_70101", "id": "reaction_10585810", "reactome": "R-DDI-177284", "name": "PKA phosphorylates PDE4B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10585799" ], "products": [ "species_10585807", "species_29370" ], "modifiers": [ [ "species_10582991", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121", "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121", "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029" ] }, "reaction_10626513": { "compartment": "compartment_70101", "id": "reaction_10626513", "reactome": "R-DDI-9644869", "name": "p-S54-PDE4B hydrolyses cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10585807", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121" ] }, "reaction_10583101": { "compartment": "compartment_70101", "id": "reaction_10583101", "reactome": "R-DDI-111962", "name": "PDE4A,C,D hydrolyse cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10583098", "catalyst" ] ], "additional_components": [ "Q86H13", "DDB_G0289121", "Q23917", "DDB_G0284331" ] }, "reaction_10584502": { "compartment": "compartment_947587", "id": "reaction_10584502", "reactome": "R-DDI-167415", "name": "G-protein alpha subunit is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29420", "species_10582953" ], "products": [ "species_29438", "species_10583103" ], "modifiers": [ [ "species_10582951", "catalyst" ] ], "additional_components": [ "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29438", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "species_29420", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351" ] }, "reaction_10584945": { "compartment": "compartment_876", "id": "reaction_10584945", "reactome": "R-DDI-170672", "name": "Galpha-olf:GTP binds to adenylate cyclase and activates it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583022", "species_10584867" ], "products": [ "species_10584942" ], "modifiers": [ [ "species_10583022", "catalyst" ] ], "additional_components": [ "species_29926", "Q03100", "DDB_G0281545", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545", "species_29926", "Q03100", "DDB_G0281545" ] }, "reaction_10584961": { "compartment": "compartment_876", "id": "reaction_10584961", "reactome": "R-DDI-170685", "name": "Adenylaye cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584942" ], "products": [ "species_10584956", "species_29372" ], "modifiers": [ [ "species_10584942", "catalyst" ] ], "additional_components": [ "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29420", "species_29926", "Q03100", "DDB_G0281545", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545" ] }, "reaction_10584954": { "compartment": "compartment_876", "id": "reaction_10584954", "reactome": "R-DDI-170676", "name": "Adenylate cyclase converts ATP into cyclic AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_111294", "species_30389" ], "modifiers": [ [ "species_10584942", "catalyst" ] ], "additional_components": [ "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545" ] }, "reaction_10584958": { "compartment": "compartment_876", "id": "reaction_10584958", "reactome": "R-DDI-170677", "name": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584956" ], "products": [ "species_10583022", "species_10584933" ], "modifiers": [], "additional_components": [ "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29420", "species_29926", "Q03100", "DDB_G0281545", "species_29926", "Q03100", "DDB_G0281545", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29420" ] }, "reaction_10589829": { "compartment": "compartment_947587", "id": "reaction_10589829", "reactome": "R-DDI-380073", "name": "Liganded Gi-activating GPCR acts as a GEF for Gi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589822", "species_29438" ], "products": [ "species_29420", "species_10589826" ], "modifiers": [ [ "species_10589822", "catalyst" ] ], "additional_components": [ "species_916850", "Q54F54", "DDB_G0291095", "Q54K09", "DDB_G0287905", "Q54ET0", "DDB_G0291356", "species_29420", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P36408", "DDB_G0277143", "P36408", "DDB_G0277143", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_916850", "Q54F54", "DDB_G0291095", "Q54K09", "DDB_G0287905", "Q54ET0", "DDB_G0291356", "species_916850", "Q54F54", "DDB_G0291095", "Q54K09", "DDB_G0287905", "Q54ET0", "DDB_G0291356", "species_29420", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P36408", "DDB_G0277143" ] }, "reaction_10624310": { "compartment": "compartment_876", "id": "reaction_10624310", "reactome": "R-DDI-8982020", "name": "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624305" ], "products": [ "species_29372", "species_10624291" ], "modifiers": [ [ "species_10624305", "catalyst" ] ], "additional_components": [ "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29420", "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438" ] }, "reaction_10624293": { "compartment": "compartment_876", "id": "reaction_10624293", "reactome": "R-DDI-8982012", "name": "G alpha (i):RGS dissociates to inactive G alpha (i)i1/i2/i3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624291" ], "products": [ "species_10624289", "species_10584947" ], "modifiers": [], "additional_components": [ "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29420", "Q54LD1", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q55E55", "DDB_G0286817", "species_29420", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343" ] }, "reaction_10601449": { "compartment": "compartment_876", "id": "reaction_10601449", "reactome": "R-DDI-2534365", "name": "Slo3 Potassium Transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10601446", "catalyst" ] ], "additional_components": [ "Q55CU6", "DDB_G0269896", "Q54SN1", "DDB_G0282291" ] }, "reaction_10583314": { "compartment": "compartment_7660", "id": "reaction_10583314", "reactome": "R-DDI-113407", "name": "DSIF complex binds to RNA Pol II (hypophosphorylated)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583215", "species_10583165" ], "products": [ "species_10583217" ], "modifiers": [], "additional_components": [ "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q75JA4", "DDB_G0271690", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q75JA4", "DDB_G0271690", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10583222": { "compartment": "compartment_7660", "id": "reaction_10583222", "reactome": "R-DDI-112383", "name": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580699", "species_10583170", "species_10578883" ], "products": [ "species_10583215", "species_10580699" ], "modifiers": [ [ "species_10583170", "catalyst" ] ], "additional_components": [ "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "DDB_G0271690", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q75JA4", "DDB_G0271690", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "DDB_G0271690" ] }, "reaction_10583320": { "compartment": "compartment_7660", "id": "reaction_10583320", "reactome": "R-DDI-113412", "name": "Pol II elongation complex moves on the template as transcript elongates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583290", "species_30595" ], "products": [ "species_10583302", "species_30595" ], "modifiers": [], "additional_components": [ "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "species_110614", "species_113592", "species_29494", "species_29438", "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "species_110614", "species_113592", "species_29494", "species_29438" ] }, "reaction_10583306": { "compartment": "compartment_7660", "id": "reaction_10583306", "reactome": "R-DDI-112396", "name": "Separation of elongating transcript from template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583302" ], "products": [ "species_10583304" ], "modifiers": [], "additional_components": [ "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10583292": { "compartment": "compartment_7660", "id": "reaction_10583292", "reactome": "R-DDI-112385", "name": "Addition of nucleotides leads to transcript elongation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583288", "species_30595" ], "products": [ "species_10583290", "species_10580699" ], "modifiers": [], "additional_components": [ "Q86A81", "DDB_G0274327", "Q55F33", "DDB_G0268922", "Q75JA4", "DDB_G0271690", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q55A48", "DDB_G0272354", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "species_110614", "species_113592", "species_29494", "species_29438", "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729" ] }, "reaction_10583692": { "compartment": "compartment_7660", "id": "reaction_10583692", "reactome": "R-DDI-156682", "name": "PLK1 phosphorylates NUDC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10583686" ], "products": [ "species_10583690", "species_29370" ], "modifiers": [ [ "species_10583678", "catalyst" ] ], "additional_components": [ "DDB_G0286159", "DDB_G0286159", "DDB_G0274503" ] }, "reaction_10601043": { "compartment": "compartment_1598585", "id": "reaction_10601043", "reactome": "R-DDI-2466068", "name": "Phosphorylation of cohesin by PLK1 at chromosomal arms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10601028" ], "products": [ "species_29370", "species_10601040" ], "modifiers": [ [ "species_10585345", "catalyst" ] ], "additional_components": [ "Q550H7", "DDB_G0276977", "Q552D9", "DDB_G0276101", "Q54QR0", "DDB_G0283681", "Q54E85", "DDB_G0291752", "Q552Q7", "DDB_G0275929", "Q552Q7", "DDB_G0275929", "Q552D9", "DDB_G0276101", "Q54QR0", "DDB_G0283681", "Q550H7", "DDB_G0276977", "Q54E85", "DDB_G0291752", "DDB_G0274503" ] }, "reaction_10589619": { "compartment": "compartment_876", "id": "reaction_10589619", "reactome": "R-DDI-375405", "name": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_375409" ], "products": [ "species_70106", "species_375414" ], "modifiers": [ [ "species_10589616", "catalyst" ] ], "additional_components": [ "species_379717", "species_159549", "species_159549", "species_379717", "DDB_G0293074" ] }, "reaction_10589624": { "compartment": "compartment_876", "id": "reaction_10589624", "reactome": "R-DDI-375417", "name": "SLC36A1-mediated uptake of glycine, proline, and alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_375400" ], "products": [ "species_70106", "species_375411" ], "modifiers": [ [ "species_10589621", "catalyst" ] ], "additional_components": [ "species_389664", "species_379717", "species_159549", "species_159549", "species_379717", "species_389664", "DDB_G0293074" ] }, "reaction_10581901": { "compartment": "compartment_7660", "id": "reaction_10581901", "reactome": "R-DDI-76056", "name": "Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581835", "species_10581897" ], "products": [ "species_10581899" ], "modifiers": [], "additional_components": [ "Q8T1F9", "DDB_G0275127", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54YB5", "DDB_G0278321", "Q54FU1", "DDB_G0290591", "Q54U85", "DDB_G0281215", "Q54R53", "DDB_G0283405", "P26355", "DDB_G0275617", "Q557J3", "DDB_G0273425", "Q54LP2", "DDB_G0286521", "Q54R66", "DDB_G0283365", "Q54IM0", "DDB_G0288665", "Q55FJ5", "DDB_G0268080", "Q86JM3", "DDB_G0272022", "Q54EH2", "DDB_G0291636", "Q54K02", "DDB_G0287707", "Q54SN4", "DDB_G0282339", "Q54FA8", "DDB_G0291037", "Q8T1V7", "DDB_G0277671", "Q86JI9", "DDB_G0271514", "Q55AB6", "DDB_G0272036", "Q86AQ5", "DDB_G0277199", "Q54IZ9", "DDB_G0288449", "Q54YW8", "DDB_G0278039", "Q557J3", "DDB_G0273425", "Q54LP2", "DDB_G0286521", "Q54R66", "DDB_G0283365", "Q54IM0", "DDB_G0288665", "Q55FJ5", "DDB_G0268080", "Q86JM3", "DDB_G0272022", "Q54EH2", "DDB_G0291636", "Q54K02", "DDB_G0287707", "Q54SN4", "DDB_G0282339", "Q54FA8", "DDB_G0291037", "Q8T1V7", "DDB_G0277671", "Q86JI9", "DDB_G0271514", "Q55AB6", "DDB_G0272036", "Q86AQ5", "DDB_G0277199", "Q54IZ9", "DDB_G0288449", "Q54YW8", "DDB_G0278039", "Q8T1F9", "DDB_G0275127", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54YB5", "DDB_G0278321", "Q54FU1", "DDB_G0290591", "Q54U85", "DDB_G0281215", "Q54R53", "DDB_G0283405", "P26355", "DDB_G0275617" ] }, "reaction_10627075": { "compartment": "compartment_876", "id": "reaction_10627075", "reactome": "R-DDI-9657599", "name": "Dual mechanism MAP2K inhibitors bind MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657567", "species_10607239" ], "products": [ "species_10607241" ], "modifiers": [], "additional_components": [ "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54HS0", "DDB_G0289277", "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54HS0", "DDB_G0289277" ] }, "reaction_10607298": { "compartment": "compartment_74700", "id": "reaction_10607298", "reactome": "R-DDI-5674130", "name": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607294", "species_113592" ], "products": [ "species_29370", "species_10607296" ], "modifiers": [], "additional_components": [ "Q54H44", "DDB_G0289711", "Q54F59", "DDB_G0291091", "Q86J23", "DDB_G0274833", "Q54TM7", "DDB_G0281557", "Q54HS0", "DDB_G0289277", "Q54H44", "DDB_G0289711", "Q54F59", "DDB_G0291091", "Q86J23", "DDB_G0274833", "Q54TM7", "DDB_G0281557", "Q54HS0", "DDB_G0289277" ] }, "reaction_10607253": { "compartment": "compartment_876", "id": "reaction_10607253", "reactome": "R-DDI-5672978", "name": "RAF phosphorylates MAP2K dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607239" ], "products": [ "species_10607230", "species_29370" ], "modifiers": [ [ "species_10607239", "catalyst" ], [ "species_10607241", "inhibitor" ], [ "species_10607251", "inhibitor" ] ], "additional_components": [ "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54HS0", "DDB_G0289277", "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54HS0", "DDB_G0289277", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54HS0", "DDB_G0289277", "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54HS0", "DDB_G0289277", "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438" ] }, "reaction_10627079": { "compartment": "compartment_876", "id": "reaction_10627079", "reactome": "R-DDI-9657606", "name": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607230", "species_9657574" ], "products": [ "species_10607237" ], "modifiers": [], "additional_components": [ "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54HS0", "DDB_G0289277", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54HS0", "DDB_G0289277", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438" ] }, "reaction_10627077": { "compartment": "compartment_876", "id": "reaction_10627077", "reactome": "R-DDI-9657603", "name": "Dual mechanism MAPK inhibitors bind MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607230", "species_9657570" ], "products": [ "species_10607243" ], "modifiers": [], "additional_components": [ "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54HS0", "DDB_G0289277", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54HS0", "DDB_G0289277", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438" ] }, "reaction_10627083": { "compartment": "compartment_876", "id": "reaction_10627083", "reactome": "R-DDI-9657608", "name": "Single mechanism MAPK inhibitors bind phosphorylated MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657577", "species_10607234" ], "products": [ "species_10627081" ], "modifiers": [], "additional_components": [ "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54HS0", "DDB_G0289277", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54HS0", "DDB_G0289277", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438" ] }, "reaction_10607245": { "compartment": "compartment_876", "id": "reaction_10607245", "reactome": "R-DDI-5672973", "name": "MAP2Ks phosphorylate MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607230", "species_113592" ], "products": [ "species_29370", "species_10607234" ], "modifiers": [ [ "species_10607230", "catalyst" ], [ "species_10607237", "inhibitor" ], [ "species_10607241", "inhibitor" ], [ "species_10607243", "inhibitor" ] ], "additional_components": [ "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54HS0", "DDB_G0289277", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602093", "species_113560" ], "products": [ "species_2485002", "species_10602506" ], "modifiers": [ [ "species_10602530", "catalyst" ] ], "additional_components": [ "Q54QM3", "DDB_G0283859", "Q54NG3", "DDB_G0285275", "B0G130", "DDB_G0279699", "Q869X5", "DDB_G0279699", "Q54PN9", "DDB_G0284411" ] }, "reaction_10602468": { "compartment": "compartment_7660", "id": "reaction_10602468", "reactome": "R-DDI-3318413", "name": "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600607", "species_113560" ], "products": [ "species_2485002", "species_10602427" ], "modifiers": [ [ "species_10602465", "catalyst" ] ], "additional_components": [ "DDB_G0291185", "DDB_G0291185", "B0G130", "DDB_G0279699", "Q869X5", "DDB_G0279699", "Q54NG3", "DDB_G0285275", "Q54PN9", "DDB_G0284411" ] }, "reaction_10602922": { "compartment": "compartment_7660", "id": "reaction_10602922", "reactome": "R-DDI-3662318", "name": "Type B histone acetlytransferase complex acetylates histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581418", "species_113560" ], "products": [ "species_2485002", "species_10602900" ], "modifiers": [ [ "species_10602919", "catalyst" ] ], "additional_components": [ "DDB_G0276863", "DDB_G0276863", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q86J12", "DDB_G0274269" ] }, "reaction_10606579": { "compartment": "compartment_7660", "id": "reaction_10606579", "reactome": "R-DDI-5661121", "name": "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606223", "species_113671", "species_113685" ], "products": [ "species_10604220", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10604227", "catalyst" ] ], "additional_components": [ "DDB_G0269194" ] }, "reaction_10604197": { "compartment": "compartment_7660", "id": "reaction_10604197", "reactome": "R-DDI-4754176", "name": "JMJD6 demethylates MeR3-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602206", "species_113671", "species_113685" ], "products": [ "species_10602093", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10604194", "catalyst" ] ], "additional_components": [ "DDB_G0279409" ] }, "reaction_10606581": { "compartment": "compartment_7660", "id": "reaction_10606581", "reactome": "R-DDI-5661122", "name": "JMJD6 demethylates Me2R3-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604669", "species_113671", "species_113685" ], "products": [ "species_10602206", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10604194", "catalyst" ] ], "additional_components": [ "DDB_G0279409" ] }, "reaction_10604215": { "compartment": "compartment_7660", "id": "reaction_10604215", "reactome": "R-DDI-4754181", "name": "KDM5A-D demethylate Me2K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113671", "species_10604199", "species_113685" ], "products": [ "species_10602091", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10604212", "catalyst" ] ], "additional_components": [ "Q55ER4", "DDB_G0268778" ] }, "reaction_10606583": { "compartment": "compartment_7660", "id": "reaction_10606583", "reactome": "R-DDI-5661124", "name": "JMJD6 demethylates MeR4-HIST1H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604614", "species_113671", "species_113685" ], "products": [ "species_10581418", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10604194", "catalyst" ] ], "additional_components": [ "DDB_G0276863", "DDB_G0276863", "DDB_G0279409" ] }, "reaction_10606585": { "compartment": "compartment_7660", "id": "reaction_10606585", "reactome": "R-DDI-5661125", "name": "JMJD6 demethylates Me2sR4-HIST1H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604678", "species_113671", "species_113685" ], "products": [ "species_10604614", "species_29478", "species_159942", "species_159939" ], "modifiers": [ [ "species_10604194", "catalyst" ] ], "additional_components": [ "DDB_G0276863", "DDB_G0276863", "DDB_G0279409" ] }, "reaction_10604232": { "compartment": "compartment_7660", "id": "reaction_10604232", "reactome": "R-DDI-4754187", "name": "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604220", "species_113671", "species_113685" ], "products": [ "species_29478", "species_159942", "species_159939", "species_10604225" ], "modifiers": [ [ "species_10604227", "catalyst" ] ], "additional_components": [ "DDB_G0269194" ] }, "reaction_10606572": { "compartment": "compartment_7660", "id": "reaction_10606572", "reactome": "R-DDI-5661116", "name": "KDM5A-D demethylate Me3K5-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604902", "species_113671", "species_113685" ], "products": [ "species_29478", "species_10604199", "species_159942", "species_159939" ], "modifiers": [ [ "species_10604212", "catalyst" ] ], "additional_components": [ "Q55ER4", "DDB_G0268778" ] }, "reaction_10627346": { "compartment": "compartment_7660", "id": "reaction_10627346", "reactome": "R-DDI-9679787", "name": "HDAC1:2-containing complex binds HDAC2 Inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603176", "species_9679795" ], "products": [ "species_10603179" ], "modifiers": [], "additional_components": [ "Q54PU3", "DDB_G0284289", "Q54LI3", "DDB_G0286805", "Q54QG3", "DDB_G0283845", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q55FN5", "DDB_G0268024", "Q54NX4", "DDB_G0285057", "Q54PU3", "DDB_G0284289", "Q54LI3", "DDB_G0286805", "Q54QG3", "DDB_G0283845", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q55FN5", "DDB_G0268024", "Q54NX4", "DDB_G0285057" ] }, "reaction_10603206": { "compartment": "compartment_7660", "id": "reaction_10603206", "reactome": "R-DDI-3782655", "name": "HDAC10 deacetylates histone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10603132" ], "products": [ "species_10603138", "species_5566518" ], "modifiers": [ [ "species_10603203", "catalyst" ] ], "additional_components": [ "Q76NW2", "DDB_G0276863", "Q54X15", "DDB_G0279267", "Q54VQ7", "DDB_G0280195" ] }, "reaction_10603181": { "compartment": "compartment_7660", "id": "reaction_10603181", "reactome": "R-DDI-3769447", "name": "HDAC1:2-containing complex deacetylate histones", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10603132" ], "products": [ "species_10603138", "species_5566518" ], "modifiers": [ [ "species_10603176", "catalyst" ], [ "species_10603179", "inhibitor" ] ], "additional_components": [ "Q76NW2", "DDB_G0276863", "Q54PU3", "DDB_G0284289", "Q54LI3", "DDB_G0286805", "Q54QG3", "DDB_G0283845", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q55FN5", "DDB_G0268024", "Q54NX4", "DDB_G0285057", "Q54PU3", "DDB_G0284289", "Q54LI3", "DDB_G0286805", "Q54QG3", "DDB_G0283845", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q55FN5", "DDB_G0268024", "Q54NX4", "DDB_G0285057" ] }, "reaction_10604673": { "compartment": "compartment_7660", "id": "reaction_10604673", "reactome": "R-DDI-5205824", "name": "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10604664" ], "products": [ "species_77502", "species_10604671" ], "modifiers": [ [ "species_10604619", "catalyst" ] ], "additional_components": [ "DDB_G0289445" ] }, "reaction_10604624": { "compartment": "compartment_7660", "id": "reaction_10604624", "reactome": "R-DDI-5205798", "name": "PRMT1,PRMT6 methylate arginine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10581418" ], "products": [ "species_77502", "species_10604614" ], "modifiers": [ [ "species_10604621", "catalyst" ] ], "additional_components": [ "DDB_G0276863", "DDB_G0276863", "Q54EF2", "DDB_G0291556", "Q54HI0", "DDB_G0289445" ] }, "reaction_10604709": { "compartment": "compartment_7660", "id": "reaction_10604709", "reactome": "R-DDI-5205867", "name": "PRMT1 methylates arginine-12 of histone H2A (H2AR11)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10604693" ], "products": [ "species_77502", "species_10604706" ], "modifiers": [ [ "species_10602098", "catalyst" ] ], "additional_components": [ "DDB_G0291556" ] }, "reaction_10604900": { "compartment": "compartment_7660", "id": "reaction_10604900", "reactome": "R-DDI-5229203", "name": "PRMT6 methylates histone H2A arginine-30 (H2AR29)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10604885" ], "products": [ "species_77502", "species_10604898" ], "modifiers": [ [ "species_10604619", "catalyst" ] ], "additional_components": [ "DDB_G0289445" ] }, "reaction_10604791": { "compartment": "compartment_7660", "id": "reaction_10604791", "reactome": "R-DDI-5225602", "name": "WDR5 binds Me2sR3-replicative histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604420", "species_10604769" ], "products": [ "species_10604789" ], "modifiers": [], "additional_components": [ "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127" ] }, "reaction_10604795": { "compartment": "compartment_7660", "id": "reaction_10604795", "reactome": "R-DDI-5225649", "name": "RBBP7 binds histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602093", "species_10602917" ], "products": [ "species_10604793" ], "modifiers": [ [ "species_10604769", "inhibitor" ] ], "additional_components": [ "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565", "Q54SD4", "DDB_G0282529", "Q54QW6", "DDB_G0283565" ] }, "reaction_10604653": { "compartment": "compartment_7660", "id": "reaction_10604653", "reactome": "R-DDI-5205820", "name": "PRMT6 methylates arginine-4 of histone H2A (H2AR3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10604637" ], "products": [ "species_77502", "species_10604650" ], "modifiers": [ [ "species_10604619", "catalyst" ] ], "additional_components": [ "DDB_G0289445" ] }, "reaction_10606590": { "compartment": "compartment_7660", "id": "reaction_10606590", "reactome": "R-DDI-5661126", "name": "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10604614" ], "products": [ "species_77502", "species_10606588" ], "modifiers": [ [ "species_10604621", "catalyst" ] ], "additional_components": [ "DDB_G0276863", "DDB_G0276863", "Q54EF2", "DDB_G0291556", "Q54HI0", "DDB_G0289445" ] }, "reaction_10606145": { "compartment": "compartment_7660", "id": "reaction_10606145", "reactome": "R-DDI-5637686", "name": "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10602091" ], "products": [ "species_77502", "species_10604199" ], "modifiers": [ [ "species_10606142", "catalyst" ] ], "additional_components": [ "Q54HS3", "DDB_G0289257", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q54MH6", "DDB_G0285847", "Q55AQ4", "DDB_G0271754", "Q54IV4", "DDB_G0288495", "Q55D68", "DDB_G0269768" ] }, "reaction_10604245": { "compartment": "compartment_7660", "id": "reaction_10604245", "reactome": "R-DDI-4827382", "name": "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10604187" ], "products": [ "species_77502", "species_10604237" ], "modifiers": [ [ "species_10604242", "catalyst" ] ], "additional_components": [ "DDB_G0289257" ] }, "reaction_10606212": { "compartment": "compartment_7660", "id": "reaction_10606212", "reactome": "R-DDI-5649764", "name": "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10606199" ], "products": [ "species_77502", "species_10606204" ], "modifiers": [ [ "species_10606209", "catalyst" ] ], "additional_components": [ "DDB_G0271626" ] }, "reaction_10604439": { "compartment": "compartment_7660", "id": "reaction_10604439", "reactome": "R-DDI-5159245", "name": "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10602093" ], "products": [ "species_77502", "species_10602091" ], "modifiers": [ [ "species_10604436", "catalyst" ] ], "additional_components": [ "Q54J80", "DDB_G0288227", "Q54HS3", "DDB_G0289257", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q54MH6", "DDB_G0285847", "Q55AQ4", "DDB_G0271754", "Q55D68", "DDB_G0269768" ] }, "reaction_10606166": { "compartment": "compartment_7660", "id": "reaction_10606166", "reactome": "R-DDI-5638157", "name": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10604185" ], "products": [ "species_77502", "species_10606159" ], "modifiers": [ [ "species_10604312", "catalyst" ] ], "additional_components": [ "Q54ZX8", "DDB_G0294629", "Q54D67", "DDB_G0294629", "Q557F6", "DDB_G0294629", "Q54DL6", "DDB_G0294629", "Q557F7", "DDB_G0294629", "Q54GG3", "DDB_G0294629", "Q55DC8", "DDB_G0270830", "Q54IV4", "DDB_G0288495", "Q55FX4", "DDB_G0294629", "Q54R14", "DDB_G0294629", "B0G196", "DDB_G0294629", "Q54XN6", "DDB_G0294629", "C7G064", "DDB_G0294629" ] }, "reaction_10604315": { "compartment": "compartment_7660", "id": "reaction_10604315", "reactome": "R-DDI-4827383", "name": "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10602093" ], "products": [ "species_77502", "species_10604185" ], "modifiers": [ [ "species_10604312", "catalyst" ] ], "additional_components": [ "Q54ZX8", "DDB_G0294629", "Q54D67", "DDB_G0294629", "Q557F6", "DDB_G0294629", "Q54DL6", "DDB_G0294629", "Q557F7", "DDB_G0294629", "Q54GG3", "DDB_G0294629", "Q55DC8", "DDB_G0270830", "Q54IV4", "DDB_G0288495", "Q55FX4", "DDB_G0294629", "Q54R14", "DDB_G0294629", "B0G196", "DDB_G0294629", "Q54XN6", "DDB_G0294629", "C7G064", "DDB_G0294629" ] }, "reaction_10606219": { "compartment": "compartment_7660", "id": "reaction_10606219", "reactome": "R-DDI-5649799", "name": "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10606204" ], "products": [ "species_77502", "species_10606217" ], "modifiers": [ [ "species_10606209", "catalyst" ] ], "additional_components": [ "DDB_G0271626" ] }, "reaction_10604909": { "compartment": "compartment_7660", "id": "reaction_10604909", "reactome": "R-DDI-5244692", "name": "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10604199" ], "products": [ "species_77502", "species_10604902" ], "modifiers": [ [ "species_10604906", "catalyst" ], [ "species_10604671", "inhibitor" ] ], "additional_components": [ "Q54HS3", "DDB_G0289257", "Q54KL5", "DDB_G0287273", "Q55DC7", "DDB_G0290127", "Q54GJ0", "DDB_G0290127", "Q54M93", "DDB_G0290127", "Q54VP0", "DDB_G0290127", "Q54K75", "DDB_G0290127", "Q54MH6", "DDB_G0285847", "Q55AQ4", "DDB_G0271754", "Q54IV4", "DDB_G0288495" ] }, "reaction_10606221": { "compartment": "compartment_7660", "id": "reaction_10606221", "reactome": "R-DDI-5649801", "name": "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10602093" ], "products": [ "species_77502", "species_10606199" ], "modifiers": [ [ "species_10606209", "catalyst" ] ], "additional_components": [ "DDB_G0271626" ] }, "reaction_10589176": { "compartment": "compartment_876", "id": "reaction_10589176", "reactome": "R-DDI-266082", "name": "ABCG1-mediated transport of intracellular cholesterol to the cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_216762", "species_113592" ], "products": [ "species_29372", "species_29370", "species_171095" ], "modifiers": [ [ "species_10589173", "catalyst" ] ], "additional_components": [ "Q8T689", "DDB_G0289657", "Q54T02", "DDB_G0282103", "Q55DA0", "DDB_G0270826", "Q55DW4", "DDB_G0269214", "Q86HQ2", "DDB_G0274117", "Q8T685", "DDB_G0274115", "Q8T686", "DDB_G0289655" ] }, "reaction_10604343": { "compartment": "compartment_7660", "id": "reaction_10604343", "reactome": "R-DDI-5082356", "name": "HSF1-mediated gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604325" ], "products": [ "species_10604331" ], "modifiers": [ [ "species_10604336", "catalyst" ], [ "species_10604341", "catalyst" ] ], "additional_components": [ "Q54UC1", "DDB_G0281165", "P54651", "DDB_G0267400", "P36415", "DDB_G0269144", "Q556J3", "DDB_G0272620", "Q54UC1", "DDB_G0281165", "Q54UC1", "DDB_G0281165" ] }, "reaction_10604364": { "compartment": "compartment_7660", "id": "reaction_10604364", "reactome": "R-DDI-5082405", "name": "Phosphorylation of HSF1 at Ser326 induces transactivation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10602818" ], "products": [ "species_113582", "species_10604341" ], "modifiers": [ [ "species_10604361", "catalyst" ] ], "additional_components": [ "Q54UC1", "DDB_G0281165", "Q54UC1", "DDB_G0281165", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54D08", "DDB_G0292592" ] }, "reaction_10590646": { "compartment": "compartment_70101", "id": "reaction_10590646", "reactome": "R-DDI-392834", "name": "Activation of EPACs by cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10590642" ], "products": [ "species_10590644" ], "modifiers": [], "additional_components": [ "Q54TK8", "DDB_G0281573", "Q8IS12", "DDB_G0275703", "Q54TK8", "DDB_G0281573", "Q8IS12", "DDB_G0275703", "species_30389" ] }, "reaction_10594377": { "compartment": "compartment_70101", "id": "reaction_10594377", "reactome": "R-DDI-913996", "name": "PKA/PKG phosphorylate Rap1GAP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10590629" ], "products": [ "species_10594364", "species_29370" ], "modifiers": [ [ "species_10594374", "catalyst" ] ], "additional_components": [ "Q54Q75", "DDB_G0284065", "Q54SS8", "DDB_G0282247", "Q54Q75", "DDB_G0284065", "Q54SS8", "DDB_G0282247", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029", "P34099", "DDB_G0283907" ] }, "reaction_10590634": { "compartment": "compartment_70101", "id": "reaction_10590634", "reactome": "R-DDI-392513", "name": "Rap1 signal termination by Rap1GAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589457" ], "products": [ "species_111294", "species_10589459" ], "modifiers": [ [ "species_10590631", "catalyst" ] ], "additional_components": [ "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "species_29438", "species_29420", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "Q54Q75", "DDB_G0284065", "Q54SS8", "DDB_G0282247" ] }, "reaction_10590655": { "compartment": "compartment_70101", "id": "reaction_10590655", "reactome": "R-DDI-392835", "name": "Rap1 sequesters Raf1 to inhibit ERK cascade", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590651", "species_10589457" ], "products": [ "species_10590653" ], "modifiers": [], "additional_components": [ "DDB_G0281557", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "species_29438", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "species_29438", "Q54TM7", "DDB_G0281557" ] }, "reaction_10582742": { "compartment": "compartment_7660", "id": "reaction_10582742", "reactome": "R-DDI-110243", "name": "Excision of 8-oxoguanine by OGG1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582737" ], "products": [ "species_110242", "species_10582739" ], "modifiers": [ [ "species_10582737", "catalyst" ] ], "additional_components": [ "Q54CZ3", "DDB_G0292618", "Q54CZ3", "DDB_G0292618", "Q54CZ3", "DDB_G0292618" ] }, "reaction_10582763": { "compartment": "compartment_7660", "id": "reaction_10582763", "reactome": "R-DDI-110246", "name": "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582758" ], "products": [ "species_5635947", "species_10582760" ], "modifiers": [ [ "species_10582758", "catalyst" ] ], "additional_components": [ "Q1ZXP7", "DDB_G0270764", "Q1ZXP7", "DDB_G0270764", "Q1ZXP7", "DDB_G0270764" ] }, "reaction_10592618": { "compartment": "compartment_70101", "id": "reaction_10592618", "reactome": "R-DDI-445072", "name": "Interaction of PAK1 with Rac1-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590366", "species_10583374", "species_113592" ], "products": [ "species_10590364", "species_29370", "species_10592615" ], "modifiers": [ [ "species_10590364", "catalyst" ] ], "additional_components": [ "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "P34144", "DDB_G0277869", "species_29438", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459", "Q869N2", "DDB_G0276459", "Q55D99", "DDB_G0269166", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "P34144", "DDB_G0277869", "species_29438", "Q55DD4", "DDB_G0269696", "Q55GV3", "DDB_G0267450", "Q55D99", "DDB_G0269166", "Q869N2", "DDB_G0276459" ] }, "reaction_10612893": { "compartment": "compartment_984", "id": "reaction_10612893", "reactome": "R-DDI-6789310", "name": "LIPs hydrolyse TG to DAG and RCOOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174675", "species_6789319" ], "modifiers": [ [ "species_10612890", "catalyst" ] ], "additional_components": [ "Q55EU1", "DDB_G0268966", "Q55EU8", "DDB_G0268966", "Q55EU9", "DDB_G0268966" ] }, "reaction_10594235": { "compartment": "compartment_876", "id": "reaction_10594235", "reactome": "R-DDI-879411", "name": "Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594231", "species_10594227" ], "products": [ "species_10594233" ], "modifiers": [], "additional_components": [ "Q55C24", "DDB_G0270260", "species_1236719", "CHEBI:60125", "CHEBI:53014", "DDB_G0287833", "Q54JR7", "DDB_G0287833", "Q55C24", "DDB_G0270260", "species_1236719", "CHEBI:60125", "CHEBI:53014" ] }, "reaction_10617470": { "compartment": "compartment_7660", "id": "reaction_10617470", "reactome": "R-DDI-6810233", "name": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10617458" ], "products": [ "species_113582", "species_10617467" ], "modifiers": [ [ "species_10617458", "catalyst" ] ], "additional_components": [ "Q54B89", "DDB_G0293830", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54XM9", "DDB_G0278843", "Q54CN8", "DDB_G0292838", "Q54IW7", "DDB_G0288471", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "P54685", "DDB_G0285417", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "P26355", "DDB_G0275617", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54FD6", "DDB_G0290929", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54XM9", "DDB_G0278843", "Q54CN8", "DDB_G0292838", "Q54IW7", "DDB_G0288471", "Q54B89", "DDB_G0293830", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "P54685", "DDB_G0285417", "P26355", "DDB_G0275617", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54FD6", "DDB_G0290929", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "P35084", "DDB_G0279193", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54B89", "DDB_G0293830", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54XM9", "DDB_G0278843", "Q54CN8", "DDB_G0292838", "Q54IW7", "DDB_G0288471", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "P54685", "DDB_G0285417", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "P26355", "DDB_G0275617", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54FD6", "DDB_G0290929" ] }, "reaction_10627486": { "compartment": "compartment_70101", "id": "reaction_10627486", "reactome": "R-DDI-9712274", "name": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622861", "species_9714134" ], "products": [ "species_10627484" ], "modifiers": [], "additional_components": [ "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903", "Q55BF8", "DDB_G0271372", "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903", "Q55BF8", "DDB_G0271372" ] }, "reaction_10591159": { "compartment": "compartment_20699", "id": "reaction_10591159", "reactome": "R-DDI-421831", "name": "trans-Golgi Network Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10591135", "species_10591129", "species_10591141", "species_10591123" ], "products": [ "species_10589294", "species_29372", "species_10591157" ], "modifiers": [], "additional_components": [ "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "O00909", "DDB_G0289173", "Q54Y34", "DDB_G0292332", "Q1ZXA5", "DDB_G0292332", "Q54YV7", "DDB_G0278057", "Q54HK2", "DDB_G0289435", "Q55AR1", "DDB_G0271792", "Q54JJ3", "DDB_G0288015", "Q54SH9", "DDB_G0282457", "Q54V41", "DDB_G0280633", "Q54V47", "DDB_G0280621", "Q54VB0", "DDB_G0280479", "species_29438", "Q54HS9", "DDB_G0289247", "Q54WW3", "DDB_G0279359", "B0G185", "DDB_G0295711", "Q8I8U2", "DDB_G0281957", "Q54X82", "DDB_G0279141", "species_29420", "Q54V41", "DDB_G0280633", "Q54Y34", "DDB_G0292332", "Q54HK2", "DDB_G0289435", "Q54YV7", "DDB_G0278057", "Q54JJ3", "DDB_G0288015", "Q54V47", "DDB_G0280621", "O00909", "DDB_G0289173", "Q54VB0", "DDB_G0280479", "Q55AR1", "DDB_G0271792", "Q1ZXA5", "DDB_G0292332", "Q54SH9", "DDB_G0282457", "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q54HS9", "DDB_G0289247", "Q54WW3", "DDB_G0279359", "B0G185", "DDB_G0295711", "Q8I8U2", "DDB_G0281957", "Q54X82", "DDB_G0279141" ] }, "reaction_10591320": { "compartment": "compartment_70101", "id": "reaction_10591320", "reactome": "R-DDI-421835", "name": "trans-Golgi Network Vesicle Scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10591157" ], "products": [ "species_10591135", "species_29372", "species_29420", "species_10591141", "species_10591317" ], "modifiers": [ [ "species_10591157", "catalyst" ] ], "additional_components": [ "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q54HS9", "DDB_G0289247", "Q54WW3", "DDB_G0279359", "B0G185", "DDB_G0295711", "Q8I8U2", "DDB_G0281957", "Q54X82", "DDB_G0279141", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q8I8U2", "DDB_G0281957", "Q54HS9", "DDB_G0289247", "B0G185", "DDB_G0295711", "Q54WW3", "DDB_G0279359", "Q54X82", "DDB_G0279141", "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q54HS9", "DDB_G0289247", "Q54WW3", "DDB_G0279359", "B0G185", "DDB_G0295711", "Q8I8U2", "DDB_G0281957", "Q54X82", "DDB_G0279141" ] }, "reaction_10589780": { "compartment": "compartment_70101", "id": "reaction_10589780", "reactome": "R-DDI-379382", "name": "MAOA:FAD deaminates DA to DOPAC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29368", "species_159362" ], "products": [ "species_9677997", "species_29382", "species_29408" ], "modifiers": [ [ "species_10583604", "catalyst" ] ], "additional_components": [ "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10589782": { "compartment": "compartment_70101", "id": "reaction_10589782", "reactome": "R-DDI-379395", "name": "MAOA:FAD deaminates 3MT to HVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8954997", "species_29356", "species_29368" ], "products": [ "species_9677992", "species_29382", "species_29408" ], "modifiers": [ [ "species_10583604", "catalyst" ] ], "additional_components": [ "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10604787": { "compartment": "compartment_70101", "id": "reaction_10604787", "reactome": "R-DDI-5223317", "name": "ABCB9 transports peptides from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5223341" ], "products": [ "species_5223344", "species_29372", "species_29370" ], "modifiers": [ [ "species_10604784", "catalyst" ] ], "additional_components": [ "Q54BU4", "DDB_G0293416" ] }, "reaction_10597683": { "compartment": "compartment_17906", "id": "reaction_10597683", "reactome": "R-DDI-1369065", "name": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1369066", "species_29356", "species_113592" ], "products": [ "species_29372", "species_29370", "species_1369027" ], "modifiers": [ [ "species_10597680", "catalyst" ] ], "additional_components": [ "Q8T9W2", "DDB_G0292554" ] }, "reaction_10590190": { "compartment": "compartment_70616", "id": "reaction_10590190", "reactome": "R-DDI-382560", "name": "ABC7, mABC1 and mABC2 mediate heme transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_189444", "species_113521" ], "products": [ "species_113548", "species_113581", "species_71185" ], "modifiers": [ [ "species_10590187", "catalyst" ] ], "additional_components": [ "Q8T9W2", "DDB_G0292554" ] }, "reaction_10619974": { "compartment": "compartment_876", "id": "reaction_10619974", "reactome": "R-DDI-8866851", "name": "CFTR transits to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619958" ], "products": [ "species_10590243" ], "modifiers": [], "additional_components": [ "Q54U44", "DDB_G0280973", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q54LE6", "DDB_G0286559", "Q54P13", "DDB_G0284867", "Q54U44", "DDB_G0280973" ] }, "reaction_10618468": { "compartment": "compartment_70101", "id": "reaction_10618468", "reactome": "R-DDI-8848053", "name": "ABCA5 transports CHOL from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_8848047" ], "products": [ "species_29372", "species_176478", "species_29370" ], "modifiers": [ [ "species_10618465", "catalyst" ] ], "additional_components": [ "Q54BT5", "DDB_G0293436", "Q55BC0", "DDB_G0271138", "Q555Z5", "DDB_G0274121", "Q8T6J1", "DDB_G0291245", "Q8T5Z7", "DDB_G0291994", "Q8T6J5", "DDB_G0267438", "Q8T6J2", "DDB_G0274119" ] }, "reaction_10590231": { "compartment": "compartment_17947", "id": "reaction_10590231", "reactome": "R-DDI-382613", "name": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590229", "species_10590211" ], "products": [ "species_10590203", "species_10590227", "species_10590211" ], "modifiers": [], "additional_components": [ "Q555I0", "DDB_G0274873", "Q8T8P3", "DDB_G0293194", "DDB_G0281213", "Q8T8P3", "DDB_G0293194", "DDB_G0274873", "DDB_G0281213" ] }, "reaction_10589110": { "compartment": "compartment_876", "id": "reaction_10589110", "reactome": "R-DDI-265783", "name": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_265784", "species_113592" ], "products": [ "species_29372", "species_29370", "species_265781" ], "modifiers": [ [ "species_10589107", "catalyst" ] ], "additional_components": [ "CHEBI:26125", "species_216762", "CHEBI:26125", "species_216762", "Q54T02", "DDB_G0282103", "Q86HQ2", "DDB_G0274117", "Q8T685", "DDB_G0274115", "Q55DA0", "DDB_G0270826", "Q55DW4", "DDB_G0269214", "Q8T686", "DDB_G0289655", "Q8T689", "DDB_G0289657" ] }, "reaction_10597819": { "compartment": "compartment_70101", "id": "reaction_10597819", "reactome": "R-DDI-1454928", "name": "ABCG4 may mediate cholesterol efflux", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176478", "species_29356", "species_113592" ], "products": [ "species_171149", "species_29372", "species_29370" ], "modifiers": [ [ "species_10597816", "catalyst" ] ], "additional_components": [ "Q8T685", "DDB_G0274115", "Q8T686", "DDB_G0289655", "Q8T689", "DDB_G0289657", "Q54T02", "DDB_G0282103", "Q55DA0", "DDB_G0270826", "Q55DW4", "DDB_G0269214", "Q86HQ2", "DDB_G0274117" ] }, "reaction_10597674": { "compartment": "compartment_876", "id": "reaction_10597674", "reactome": "R-DDI-1369028", "name": "ABCAs mediate lipid efflux", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_176478", "species_113592" ], "products": [ "species_171149", "species_29372", "species_29370" ], "modifiers": [ [ "species_10597671", "catalyst" ] ], "additional_components": [] }, "reaction_10597676": { "compartment": "compartment_876", "id": "reaction_10597676", "reactome": "R-DDI-1369052", "name": "ABCAs mediate lipid influx", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_171149", "species_29356", "species_113592" ], "products": [ "species_29372", "species_176478", "species_29370" ], "modifiers": [ [ "species_10597671", "catalyst" ] ], "additional_components": [] }, "reaction_10607964": { "compartment": "compartment_70101", "id": "reaction_10607964", "reactome": "R-DDI-5682285", "name": "ABCA12 transports lipids from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5682283", "species_29356", "species_113592" ], "products": [ "species_29372", "species_29370", "species_5229279" ], "modifiers": [ [ "species_10607961", "catalyst" ] ], "additional_components": [ "Q8T5Z7", "DDB_G0291994", "Q8T6J1", "DDB_G0291245", "Q8T6J2", "DDB_G0274119", "Q8T6J5", "DDB_G0267438", "Q54BT5", "DDB_G0293436", "Q555Z5", "DDB_G0274121", "Q55BC0", "DDB_G0271138" ] }, "reaction_10590206": { "compartment": "compartment_17947", "id": "reaction_10590206", "reactome": "R-DDI-382575", "name": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_382577" ], "products": [ "species_382571", "species_29372", "species_29370" ], "modifiers": [ [ "species_10590203", "catalyst" ] ], "additional_components": [ "Q8T8P3", "DDB_G0293194" ] }, "reaction_10590246": { "compartment": "compartment_876", "id": "reaction_10590246", "reactome": "R-DDI-383190", "name": "HCO3- transport through ion channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111627", "species_113592" ], "products": [ "species_29372", "species_29370", "species_425425" ], "modifiers": [ [ "species_10590243", "catalyst" ] ], "additional_components": [ "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q54LE6", "DDB_G0286559", "Q54P13", "DDB_G0284867", "Q54U44", "DDB_G0280973" ] }, "reaction_10597798": { "compartment": "compartment_70101", "id": "reaction_10597798", "reactome": "R-DDI-1454916", "name": "The ABCC family mediates organic anion transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_1454930" ], "products": [ "species_29372", "species_29370", "species_1454919" ], "modifiers": [ [ "species_10597795", "catalyst" ] ], "additional_components": [ "Q54EK2", "DDB_G0291243", "Q54K24", "DDB_G0287589", "Q54NL1", "DDB_G0285165", "Q54V86", "DDB_G0280539", "Q54VC1", "DDB_G0280459", "Q54VJ0", "DDB_G0280055", "Q8T6H3", "DDB_G0287593", "Q8T6H8", "DDB_G0280541", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q54LE6", "DDB_G0286559", "Q54P13", "DDB_G0284867", "Q54U44", "DDB_G0280973" ] }, "reaction_10619962": { "compartment": "compartment_70101", "id": "reaction_10619962", "reactome": "R-DDI-8866553", "name": "misfolded CFTR is degraded by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619960" ], "products": [ "species_10577037" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q54U44", "DDB_G0280973", "Q54P13", "DDB_G0284867", "Q8ST87", "DDB_G0280977", "Q54LE6", "DDB_G0286559", "Q54JR2", "DDB_G0287691", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10597848": { "compartment": "compartment_876", "id": "reaction_10597848", "reactome": "R-DDI-1467457", "name": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_1131652" ], "products": [ "species_29372", "species_29370", "species_1467459" ], "modifiers": [ [ "species_10597845", "catalyst" ] ], "additional_components": [ "Q8T9W4", "DDB_G0291714", "Q54BT3", "DDB_G0293438", "Q55BC0", "DDB_G0271138", "Q8T5Z7", "DDB_G0291994", "Q8T6J1", "DDB_G0291245", "Q8T6J2", "DDB_G0274119", "Q8T6J5", "DDB_G0267438", "Q54BT5", "DDB_G0293436", "Q555Z5", "DDB_G0274121" ] }, "reaction_10607707": { "compartment": "compartment_984", "id": "reaction_10607707", "reactome": "R-DDI-5678706", "name": "ABCB4 transports PC from plasma membrane to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429802", "species_113592" ], "products": [ "species_382539", "species_29372", "species_29370" ], "modifiers": [ [ "species_10607704", "catalyst" ] ], "additional_components": [ "Q54BT3", "DDB_G0293438", "Q8T9W4", "DDB_G0291714" ] }, "reaction_10597867": { "compartment": "compartment_74000", "id": "reaction_10597867", "reactome": "R-DDI-1467466", "name": "ABCA4 mediates atRAL transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_2466098" ], "products": [ "species_29372", "species_29370", "species_975622" ], "modifiers": [ [ "species_10597864", "catalyst" ] ], "additional_components": [ "Q8T5Z7", "DDB_G0291994", "Q8T6J1", "DDB_G0291245", "Q8T6J2", "DDB_G0274119", "Q8T6J5", "DDB_G0267438", "Q54BT5", "DDB_G0293436", "Q555Z5", "DDB_G0274121", "Q55BC0", "DDB_G0271138" ] }, "reaction_10604826": { "compartment": "compartment_70101", "id": "reaction_10604826", "reactome": "R-DDI-5227009", "name": "ABCF1 binds EIF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604822", "species_10580002" ], "products": [ "species_10604824" ], "modifiers": [], "additional_components": [ "DDB_G0267436", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "Q54XD8", "DDB_G0278967", "Q869N9", "DDB_G0271862", "Q54T27", "DDB_G0282035", "Q8T6B4", "DDB_G0267436" ] }, "reaction_10607710": { "compartment": "compartment_70101", "id": "reaction_10607710", "reactome": "R-DDI-5678863", "name": "CFTR transports Cl- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_352022" ], "products": [ "species_188972", "species_29372", "species_29370" ], "modifiers": [ [ "species_10590243", "catalyst" ] ], "additional_components": [ "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q54LE6", "DDB_G0286559", "Q54P13", "DDB_G0284867", "Q54U44", "DDB_G0280973" ] }, "reaction_10584149": { "compartment": "compartment_70101", "id": "reaction_10584149", "reactome": "R-DDI-165162", "name": "Phosphorylation of TSC2 by PKB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584141", "species_113592" ], "products": [ "species_29370", "species_10584146" ], "modifiers": [ [ "species_10582598", "catalyst" ] ], "additional_components": [ "DDB_G0280527", "DDB_G0280527", "Q54IF2", "DDB_G0288795", "P54644", "DDB_G0268620", "species_179838" ] }, "reaction_10624166": { "compartment": "compartment_876", "id": "reaction_10624166", "reactome": "R-DDI-8981353", "name": "RASA1 stimulates RAS GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624163" ], "products": [ "species_10585895", "species_10585874" ], "modifiers": [ [ "species_10624163", "catalyst" ] ], "additional_components": [ "Q54Q13", "DDB_G0284177", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "DDB_G0284177", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29420", "Q54Q13", "DDB_G0284177", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438" ] }, "reaction_10624168": { "compartment": "compartment_876", "id": "reaction_10624168", "reactome": "R-DDI-8981355", "name": "RASA1 binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585144", "species_10585895" ], "products": [ "species_10624163" ], "modifiers": [], "additional_components": [ "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "DDB_G0284177", "Q54Q13", "DDB_G0284177", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438" ] }, "reaction_10617858": { "compartment": "compartment_263163", "id": "reaction_10617858", "reactome": "R-DDI-6814088", "name": "SYS1 binds AcM-ARFRP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617856", "species_10617826" ], "products": [ "species_10617836" ], "modifiers": [], "additional_components": [ "Q54QU7", "DDB_G0283631", "species_29438", "DDB_G0269368", "Q55E69", "DDB_G0269368", "Q54QU7", "DDB_G0283631", "species_29438" ] }, "reaction_10617680": { "compartment": "compartment_263163", "id": "reaction_10617680", "reactome": "R-DDI-6811428", "name": "RIC1:RGP1 recruits RAB6:GDP to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617658", "species_10617670" ], "products": [ "species_10617678" ], "modifiers": [], "additional_components": [ "Q55FK2", "DDB_G0268068", "species_29420", "Q54WR7", "DDB_G0279477", "Q76NU4", "DDB_G0277397", "Q54WR7", "DDB_G0279477", "Q76NU4", "DDB_G0277397", "Q55FK2", "DDB_G0268068", "species_29420" ] }, "reaction_10618272": { "compartment": "compartment_263163", "id": "reaction_10618272", "reactome": "R-DDI-6814678", "name": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618267", "species_113592" ], "products": [ "species_10611694", "species_10618041", "species_10617977", "species_29370", "species_10611703", "species_10617975", "species_10617985" ], "modifiers": [ [ "species_10618267", "catalyst" ] ], "additional_components": [ "Q54CK6", "DDB_G0292974", "Q553C3", "DDB_G0275765", "Q54R67", "DDB_G0283363", "Q54I20", "DDB_G0289063", "Q551H5", "DDB_G0276575", "Q54GB3", "DDB_G0290363", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153", "Q75JI3", "DDB_G0276153", "DDB_G0290363", "DDB_G0276575", "Q54NP6", "DDB_G0285111", "DDB_G0289063", "Q54CK6", "DDB_G0292974", "Q553C3", "DDB_G0275765", "Q54R67", "DDB_G0283363", "Q54CK6", "DDB_G0292974", "Q553C3", "DDB_G0275765", "Q54R67", "DDB_G0283363", "Q54I20", "DDB_G0289063", "Q551H5", "DDB_G0276575", "Q54GB3", "DDB_G0290363", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153" ] }, "reaction_10617687": { "compartment": "compartment_263163", "id": "reaction_10617687", "reactome": "R-DDI-6811429", "name": "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10617678" ], "products": [ "species_29420", "species_10617684" ], "modifiers": [ [ "species_10617678", "catalyst" ] ], "additional_components": [ "Q54WR7", "DDB_G0279477", "Q76NU4", "DDB_G0277397", "Q55FK2", "DDB_G0268068", "species_29420", "Q55FK2", "DDB_G0268068", "species_29438", "Q54WR7", "DDB_G0279477", "Q76NU4", "DDB_G0277397", "Q54WR7", "DDB_G0279477", "Q76NU4", "DDB_G0277397", "Q55FK2", "DDB_G0268068", "species_29420" ] }, "reaction_10618359": { "compartment": "compartment_263163", "id": "reaction_10618359", "reactome": "R-DDI-8847537", "name": "RAB43:GTP binds USP8NL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618357", "species_10618342" ], "products": [ "species_10618344" ], "modifiers": [], "additional_components": [ "Q54Z16", "DDB_G0289735", "Q54H32", "DDB_G0289735", "Q54SD0", "DDB_G0282537", "species_29438", "Q54SD0", "DDB_G0282537", "species_29438", "Q54H32", "DDB_G0289735", "Q54Z16", "DDB_G0289735" ] }, "reaction_10618312": { "compartment": "compartment_263163", "id": "reaction_10618312", "reactome": "R-DDI-6814684", "name": "cis-SNARE binds SNAPs and NSF hexamer at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611694", "species_10611703", "species_10618308" ], "products": [ "species_10618310" ], "modifiers": [], "additional_components": [ "Q75JI3", "DDB_G0276153", "Q54NP6", "DDB_G0285111", "Q54I20", "DDB_G0289063", "Q54PW2", "DDB_G0284185", "Q54PQ5", "DDB_G0289063", "Q54CK6", "DDB_G0292974", "Q553C3", "DDB_G0275765", "Q54R67", "DDB_G0283363", "Q551H5", "DDB_G0276575", "Q54I20", "DDB_G0289063", "Q54PW2", "DDB_G0284185", "Q54PQ5", "DDB_G0289063", "Q54CK6", "DDB_G0292974", "Q553C3", "DDB_G0275765", "Q54R67", "DDB_G0283363", "Q551H5", "DDB_G0276575", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153" ] }, "reaction_10618351": { "compartment": "compartment_263163", "id": "reaction_10618351", "reactome": "R-DDI-8847534", "name": "RAB43 hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618344" ], "products": [ "species_10618348" ], "modifiers": [ [ "species_10618344", "catalyst" ] ], "additional_components": [ "Q54SD0", "DDB_G0282537", "species_29438", "Q54H32", "DDB_G0289735", "Q54Z16", "DDB_G0289735", "Q54SD0", "DDB_G0282537", "species_29420", "Q54H32", "DDB_G0289735", "Q54Z16", "DDB_G0289735", "Q54SD0", "DDB_G0282537", "species_29438", "Q54H32", "DDB_G0289735", "Q54Z16", "DDB_G0289735" ] }, "reaction_10617852": { "compartment": "compartment_263163", "id": "reaction_10617852", "reactome": "R-DDI-6814086", "name": "ARFRP1 recruits ARL1 to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617836", "species_10617844" ], "products": [ "species_10617850" ], "modifiers": [], "additional_components": [ "Q55E69", "DDB_G0269368", "Q54QU7", "DDB_G0283631", "species_29438", "Q54JB7", "DDB_G0288163", "species_29438", "Q54JB7", "DDB_G0288163", "species_29438", "Q55E69", "DDB_G0269368", "Q54QU7", "DDB_G0283631" ] }, "reaction_10617869": { "compartment": "compartment_263163", "id": "reaction_10617869", "reactome": "R-DDI-6814091", "name": "ARL1 recruits TGN Golgin homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10617865", "species_10617850" ], "products": [ "species_10617867" ], "modifiers": [], "additional_components": [ "Q556B3", "DDB_G0274785", "Q54JB7", "DDB_G0288163", "species_29438", "Q55E69", "DDB_G0269368", "Q54QU7", "DDB_G0283631", "Q54JB7", "DDB_G0288163", "species_29438", "Q55E69", "DDB_G0269368", "Q54QU7", "DDB_G0283631", "Q556B3", "DDB_G0274785" ] }, "reaction_10618269": { "compartment": "compartment_263163", "id": "reaction_10618269", "reactome": "R-DDI-6814676", "name": "SNAPs and NSF hexamer bind cis-SNARE at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611694", "species_10611703", "species_10618103" ], "products": [ "species_10618267" ], "modifiers": [], "additional_components": [ "Q75JI3", "DDB_G0276153", "Q54NP6", "DDB_G0285111", "Q54CK6", "DDB_G0292974", "Q553C3", "DDB_G0275765", "Q54R67", "DDB_G0283363", "Q54I20", "DDB_G0289063", "Q551H5", "DDB_G0276575", "Q54GB3", "DDB_G0290363", "Q54CK6", "DDB_G0292974", "Q553C3", "DDB_G0275765", "Q54R67", "DDB_G0283363", "Q54I20", "DDB_G0289063", "Q551H5", "DDB_G0276575", "Q54GB3", "DDB_G0290363", "Q54NP6", "DDB_G0285111", "Q75JI3", "DDB_G0276153" ] }, "reaction_10623407": { "compartment": "compartment_70616", "id": "reaction_10623407", "reactome": "R-DDI-8949178", "name": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8949232" ], "products": [ "species_8949220" ], "modifiers": [ [ "species_10623404", "catalyst" ] ], "additional_components": [ "Q54JS1", "DDB_G0287825", "Q54LT0", "DDB_G0286429" ] }, "reaction_10592489": { "compartment": "compartment_876", "id": "reaction_10592489", "reactome": "R-DDI-442422", "name": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10592486", "catalyst" ] ], "additional_components": [ "Q55EA1", "DDB_G0269326", "Q54MB9", "DDB_G0286049" ] }, "reaction_10583681": { "compartment": "compartment_7660", "id": "reaction_10583681", "reactome": "R-DDI-156678", "name": "Activation of Cdc25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10583669" ], "products": [ "species_29370", "species_10583672" ], "modifiers": [ [ "species_10583678", "catalyst" ] ], "additional_components": [ "DDB_G0283617", "DDB_G0283617", "DDB_G0274503" ] }, "reaction_10583700": { "compartment": "compartment_7660", "id": "reaction_10583700", "reactome": "R-DDI-156699", "name": "Inactivation of Wee1 kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10577525" ], "products": [ "species_113582", "species_10583695" ], "modifiers": [ [ "species_10583697", "catalyst" ] ], "additional_components": [ "DDB_G0277539", "DDB_G0277539", "DDB_G0274503" ] }, "reaction_10583863": { "compartment": "compartment_7660", "id": "reaction_10583863", "reactome": "R-DDI-162657", "name": "Inactivation of Myt1 kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10583858" ], "products": [ "species_113582", "species_10583861" ], "modifiers": [ [ "species_10583697", "catalyst" ] ], "additional_components": [ "DDB_G0291133", "DDB_G0291133", "DDB_G0274503" ] }, "reaction_10600890": { "compartment": "compartment_984", "id": "reaction_10600890", "reactome": "R-DDI-2328033", "name": "Fibrillin-1 binds latent TGF-beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600886", "species_10600215" ], "products": [ "species_10600888" ], "modifiers": [], "additional_components": [ "Q559U0", "DDB_G0278613", "Q54YP0", "DDB_G0278613", "Q54IA3", "DDB_G0295485", "B0G154", "DDB_G0295485", "Q54IA3", "DDB_G0295485", "B0G154", "DDB_G0295485", "Q559U0", "DDB_G0278613", "Q54YP0", "DDB_G0278613" ] }, "reaction_10600223": { "compartment": "compartment_984", "id": "reaction_10600223", "reactome": "R-DDI-2129362", "name": "Fibrillin microfibril assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600193" ], "products": [ "species_10600221" ], "modifiers": [], "additional_components": [ "Q54IA3", "DDB_G0295485", "B0G154", "DDB_G0295485", "Q54IA3", "DDB_G0295485", "B0G154", "DDB_G0295485" ] }, "reaction_10601589": { "compartment": "compartment_70101", "id": "reaction_10601589", "reactome": "R-DDI-2730896", "name": "Phosphorylation of MEK4 by MEKK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10593048" ], "products": [ "species_29370", "species_10593058" ], "modifiers": [ [ "species_10601580", "catalyst" ] ], "additional_components": [ "DDB_G0289277", "DDB_G0289277", "Q54PX0", "DDB_G0284251", "Q55CA6", "DDB_G0284251", "Q8T2I8", "DDB_G0276465" ] }, "reaction_10601583": { "compartment": "compartment_70101", "id": "reaction_10601583", "reactome": "R-DDI-2730868", "name": "Phosphorylation of MEK7 by MEKK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10593046" ], "products": [ "species_10593054", "species_29370" ], "modifiers": [ [ "species_10601580", "catalyst" ] ], "additional_components": [ "DDB_G0289277", "DDB_G0289277", "Q54PX0", "DDB_G0284251", "Q55CA6", "DDB_G0284251", "Q8T2I8", "DDB_G0276465" ] }, "reaction_10626182": { "compartment": "compartment_70101", "id": "reaction_10626182", "reactome": "R-DDI-9619355", "name": "CaMKK autophosphorylates in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626175", "species_113592" ], "products": [ "species_29370", "species_10626179" ], "modifiers": [ [ "species_10626175", "catalyst" ] ], "additional_components": [ "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "Q55CW1", "DDB_G0270680", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "Q55CW1", "DDB_G0270680", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "Q55CW1", "DDB_G0270680" ] }, "reaction_10626191": { "compartment": "compartment_70101", "id": "reaction_10626191", "reactome": "R-DDI-9619376", "name": "CAMK1 binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626187", "species_10583042" ], "products": [ "species_10626189" ], "modifiers": [], "additional_components": [ "DDB_G0279925", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "P25323", "DDB_G0279925" ] }, "reaction_10585189": { "compartment": "compartment_70101", "id": "reaction_10585189", "reactome": "R-DDI-174054", "name": "Formation of Cyclin A:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577493", "species_10584819" ], "products": [ "species_10585187" ], "modifiers": [], "additional_components": [ "DDB_G0272813", "P34112", "DDB_G0272813" ] }, "reaction_10585460": { "compartment": "compartment_13231", "id": "reaction_10585460", "reactome": "R-DDI-174273", "name": "Translocation of Cyclin A:Cdk2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585187" ], "products": [ "species_10585380" ], "modifiers": [], "additional_components": [ "P34112", "DDB_G0272813", "P34112", "DDB_G0272813" ] }, "reaction_10585924": { "compartment": "compartment_7660", "id": "reaction_10585924", "reactome": "R-DDI-187948", "name": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10585920" ], "products": [ "species_113582", "species_10585922" ], "modifiers": [ [ "species_10576705", "catalyst" ] ], "additional_components": [ "Q54FX2", "DDB_G0290551", "Q54KM3", "DDB_G0287259", "Q54FX2", "DDB_G0290551", "Q54KM3", "DDB_G0287259", "P34112", "DDB_G0272813" ] }, "reaction_10585927": { "compartment": "compartment_7660", "id": "reaction_10585927", "reactome": "R-DDI-187949", "name": "CAK-mediated phosphorylation of Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10585380" ], "products": [ "species_113582", "species_10576705" ], "modifiers": [ [ "species_10580662", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "P34112", "DDB_G0272813", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668" ] }, "reaction_10585382": { "compartment": "compartment_7660", "id": "reaction_10585382", "reactome": "R-DDI-174110", "name": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10585378" ], "products": [ "species_113550", "species_10585380" ], "modifiers": [ [ "species_10577539", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "P34112", "DDB_G0272813", "DDB_G0283617" ] }, "reaction_10585914": { "compartment": "compartment_7660", "id": "reaction_10585914", "reactome": "R-DDI-187574", "name": "Degradation of ubiquitinated p27/p21 by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585912" ], "products": [ "species_10577273", "species_10585908", "species_10576865" ], "modifiers": [ [ "species_10585327", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "B0G102", "DDB_G0271642", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "B0G102", "DDB_G0271642", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q27563", "DDB_G0267408", "P02889", "DDB_G0272564", "P34119", "DDB_G0280969", "Q552Y8", "DDB_G0275753", "Q55G04", "DDB_G0268538", "Q967U1", "DDB_G0285099", "Q54XM7", "DDB_G0278847", "P34120", "DDB_G0272831", "Q86A21", "DDB_G0272969", "Q54S82", "DDB_G0282617", "Q54QR2", "DDB_G0283679", "Q55DY7", "DDB_G0269472", "Q55D66", "DDB_G0269772", "Q556Q0", "DDB_G0273163", "Q54BC8", "DDB_G0293784", "Q55GJ6", "DDB_G0267390", "Q55BV5", "DDB_G0270784", "Q86JA1", "DDB_G0276917", "Q54PN7", "DDB_G0284415", "P34123", "DDB_G0289003", "P34124", "DDB_G0292382", "Q54PJ1", "DDB_G0284517", "Q54JM5", "DDB_G0287953", "Q54HW1", "DDB_G0289189", "Q54UB5", "DDB_G0281315", "Q54UJ0", "DDB_G0281051", "Q54NQ0", "DDB_G0285105", "Q54BC6", "DDB_G0293752", "Q1ZXD3", "DDB_G0288621", "Q553E0", "DDB_G0275775", "Q86IJ1", "DDB_G0272566", "Q559F4", "DDB_G0272951", "Q27562", "DDB_G0282363", "Q55C75", "DDB_G0270188", "Q54DM7", "DDB_G0292122", "Q54WI8", "DDB_G0279633" ] }, "reaction_10585439": { "compartment": "compartment_7660", "id": "reaction_10585439", "reactome": "R-DDI-174164", "name": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10585380" ], "products": [ "species_113582", "species_10585378" ], "modifiers": [ [ "species_10577525", "catalyst" ], [ "species_10577531", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "P34112", "DDB_G0272813", "DDB_G0277539", "DDB_G0302543" ] }, "reaction_10601123": { "compartment": "compartment_7660", "id": "reaction_10601123", "reactome": "R-DDI-2468039", "name": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601103", "species_113560" ], "products": [ "species_2485002", "species_10601111" ], "modifiers": [ [ "species_10601120", "catalyst" ] ], "additional_components": [ "Q54QR0", "DDB_G0283681", "Q54E85", "DDB_G0291752", "Q552D9", "DDB_G0276101", "Q550H7", "DDB_G0276977", "Q552Q7", "DDB_G0275929", "Q54QR0", "DDB_G0283681", "Q552D9", "DDB_G0276101", "Q54E85", "DDB_G0291752", "Q550H7", "DDB_G0276977", "Q552Q7", "DDB_G0275929", "Q54W25", "DDB_G0279959" ] }, "reaction_10601155": { "compartment": "compartment_7660", "id": "reaction_10601155", "reactome": "R-DDI-2473152", "name": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601151", "species_113560" ], "products": [ "species_2485002", "species_10601153" ], "modifiers": [ [ "species_10601120", "catalyst" ] ], "additional_components": [ "Q54QR0", "DDB_G0283681", "Q54E85", "DDB_G0291752", "Q552D9", "DDB_G0276101", "Q550H7", "DDB_G0276977", "Q552Q7", "DDB_G0275929", "Q54QR0", "DDB_G0283681", "Q552D9", "DDB_G0276101", "Q54E85", "DDB_G0291752", "Q550H7", "DDB_G0276977", "Q552Q7", "DDB_G0275929", "Q54W25", "DDB_G0279959" ] }, "reaction_10585939": { "compartment": "compartment_7660", "id": "reaction_10585939", "reactome": "R-DDI-187959", "name": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10585916" ], "products": [ "species_113582", "species_10585936" ], "modifiers": [ [ "species_10585916", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q54Q23", "DDB_G0284129", "P34112", "DDB_G0272813", "Q54Q23", "DDB_G0284129", "P34112", "DDB_G0272813", "Q54Q23", "DDB_G0284129" ] }, "reaction_10585918": { "compartment": "compartment_7660", "id": "reaction_10585918", "reactome": "R-DDI-187937", "name": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10576524", "species_10576705" ], "products": [ "species_10585916" ], "modifiers": [], "additional_components": [ "Q54Q23", "DDB_G0284129", "P34112", "DDB_G0272813", "P34112", "DDB_G0272813", "Q54Q23", "DDB_G0284129" ] }, "reaction_10619259": { "compartment": "compartment_70101", "id": "reaction_10619259", "reactome": "R-DDI-8854041", "name": "SCF-FBXL7 ubiquitinates AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10619191" ], "products": [ "species_10619256" ], "modifiers": [ [ "species_10619191", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54WX4", "DDB_G0279343", "Q54WX4", "DDB_G0279343", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54WX4", "DDB_G0279343" ] }, "reaction_10619193": { "compartment": "compartment_70101", "id": "reaction_10619193", "reactome": "R-DDI-8853496", "name": "SCF:FBXL7 binds AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585350", "species_10619189" ], "products": [ "species_10619191" ], "modifiers": [], "additional_components": [ "DDB_G0279343", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54WX4", "DDB_G0279343" ] }, "reaction_10619261": { "compartment": "compartment_70101", "id": "reaction_10619261", "reactome": "R-DDI-8854044", "name": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619256" ], "products": [ "species_10577037", "species_10619189" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q54WX4", "DDB_G0279343", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K33", "DDB_G0287629", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10584837": { "compartment": "compartment_13231", "id": "reaction_10584837", "reactome": "R-DDI-170159", "name": "Translocation of Cdc25 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584833" ], "products": [ "species_10584835" ], "modifiers": [], "additional_components": [ "Q54QM6", "DDB_G0283617", "Q54QM6", "DDB_G0283617" ] }, "reaction_10619653": { "compartment": "compartment_7660", "id": "reaction_10619653", "reactome": "R-DDI-8856951", "name": "PP2A demethylation by PPME1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10619637" ], "products": [ "species_10597550", "species_8857797" ], "modifiers": [ [ "species_10619650", "catalyst" ] ], "additional_components": [ "DDB_G0281651" ] }, "reaction_10584825": { "compartment": "compartment_13231", "id": "reaction_10584825", "reactome": "R-DDI-170120", "name": "Translocation of Cdc25B to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584821" ], "products": [ "species_10584823" ], "modifiers": [], "additional_components": [ "DDB_G0283617", "DDB_G0283617" ] }, "reaction_10584829": { "compartment": "compartment_13231", "id": "reaction_10584829", "reactome": "R-DDI-170149", "name": "Translocation of active Cdc25C to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583672" ], "products": [ "species_10584827" ], "modifiers": [], "additional_components": [ "DDB_G0283617", "DDB_G0283617" ] }, "reaction_10619645": { "compartment": "compartment_7660", "id": "reaction_10619645", "reactome": "R-DDI-8856945", "name": "PP2A methylation by LCMT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597550", "species_77087" ], "products": [ "species_77502", "species_10619637" ], "modifiers": [ [ "species_10619642", "catalyst" ] ], "additional_components": [ "DDB_G0288271" ] }, "reaction_10601941": { "compartment": "compartment_70101", "id": "reaction_10601941", "reactome": "R-DDI-3002798", "name": "Cytosolic PLK1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583678" ], "products": [ "species_10583697" ], "modifiers": [], "additional_components": [ "DDB_G0274503", "DDB_G0274503" ] }, "reaction_10601061": { "compartment": "compartment_70101", "id": "reaction_10601061", "reactome": "R-DDI-2467775", "name": "Autocleavage of ESPL1 (Separase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601050" ], "products": [ "species_10601058" ], "modifiers": [ [ "species_10601050", "catalyst" ] ], "additional_components": [ "DDB_G0290325", "Q54G81", "DDB_G0290325", "DDB_G0290325" ] }, "reaction_10600560": { "compartment": "compartment_7660", "id": "reaction_10600560", "reactome": "R-DDI-2168079", "name": "MASTL (GWL) phosphorylates ARPP19", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10600546" ], "products": [ "species_113582", "species_10600549" ], "modifiers": [ [ "species_10600557", "catalyst" ] ], "additional_components": [ "DDB_G0283571", "DDB_G0283571", "DDB_G0272282" ] }, "reaction_10600987": { "compartment": "compartment_7660", "id": "reaction_10600987", "reactome": "R-DDI-2430535", "name": "MASTL phosphorylates ENSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10600982" ], "products": [ "species_113582", "species_10600985" ], "modifiers": [ [ "species_10600557", "catalyst" ] ], "additional_components": [ "DDB_G0283571", "DDB_G0283571", "DDB_G0272282" ] }, "reaction_10600815": { "compartment": "compartment_20699", "id": "reaction_10600815", "reactome": "R-DDI-2214351", "name": "PLK1 phosphorylates GORASP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10600807" ], "products": [ "species_10600812", "species_29370" ], "modifiers": [ [ "species_10600807", "catalyst" ] ], "additional_components": [ "P34139", "DDB_G0283757", "species_29438", "Q54C46", "DDB_G0293248", "Q86HN7", "DDB_G0274503", "P34139", "DDB_G0283757", "species_29438", "Q54C46", "DDB_G0293248", "Q86HN7", "DDB_G0274503", "P34139", "DDB_G0283757", "species_29438", "Q54C46", "DDB_G0293248", "Q86HN7", "DDB_G0274503" ] }, "reaction_10585968": { "compartment": "compartment_7660", "id": "reaction_10585968", "reactome": "R-DDI-188390", "name": "Cyclin E:CDK2-mediated phosphorylation of RB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10585963" ], "products": [ "species_113582", "species_10577271", "species_10583328" ], "modifiers": [ [ "species_10585963", "catalyst" ] ], "additional_components": [ "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "P34112", "DDB_G0272813", "Q54FX2", "DDB_G0290551", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "P34112", "DDB_G0272813", "DDB_G0290551", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "P34112", "DDB_G0272813", "Q54FX2", "DDB_G0290551" ] }, "reaction_10577511": { "compartment": "compartment_70101", "id": "reaction_10577511", "reactome": "R-DDI-69191", "name": "Formation of Cyclin E:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577493", "species_10577507" ], "products": [ "species_10577509" ], "modifiers": [], "additional_components": [ "DDB_G0272813", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "P34112", "DDB_G0272813" ] }, "reaction_10585959": { "compartment": "compartment_7660", "id": "reaction_10585959", "reactome": "R-DDI-188350", "name": "CAK-mediated phosphorylation of Cyclin E:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10577515" ], "products": [ "species_113582", "species_10577271" ], "modifiers": [ [ "species_10580662", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "P34112", "DDB_G0272813", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668" ] }, "reaction_10577542": { "compartment": "compartment_7660", "id": "reaction_10577542", "reactome": "R-DDI-69199", "name": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10577520" ], "products": [ "species_113550", "species_10577515" ], "modifiers": [ [ "species_10577539", "catalyst" ] ], "additional_components": [ "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "P34112", "DDB_G0272813", "P34112", "DDB_G0272813", "DDB_G0283617" ] }, "reaction_10577533": { "compartment": "compartment_7660", "id": "reaction_10577533", "reactome": "R-DDI-69195", "name": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10577515" ], "products": [ "species_113582", "species_10577520" ], "modifiers": [ [ "species_10577525", "catalyst" ], [ "species_10577531", "catalyst" ] ], "additional_components": [ "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "P34112", "DDB_G0272813", "DDB_G0277539", "DDB_G0302543" ] }, "reaction_10585965": { "compartment": "compartment_7660", "id": "reaction_10585965", "reactome": "R-DDI-188386", "name": "Association of Rb with Cyclin E:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577550", "species_10577271" ], "products": [ "species_10585963" ], "modifiers": [], "additional_components": [ "DDB_G0290551", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "P34112", "DDB_G0272813", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "P34112", "DDB_G0272813", "Q54FX2", "DDB_G0290551" ] }, "reaction_10583775": { "compartment": "compartment_13231", "id": "reaction_10583775", "reactome": "R-DDI-157906", "name": "Translocation of Cyclin E:Cdk2 complex to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577509" ], "products": [ "species_10577515" ], "modifiers": [], "additional_components": [ "P42524", "DDB_G0275493", "Q8T2F2", "DDB_G0277439", "P34112", "DDB_G0272813", "P34112", "DDB_G0272813" ] }, "reaction_10583356": { "compartment": "compartment_7660", "id": "reaction_10583356", "reactome": "R-DDI-113503", "name": "PP2A mediated localization of RB1 protein in chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_113656", "species_10583328" ], "products": [ "species_113550", "species_10583330" ], "modifiers": [ [ "species_10583353", "catalyst" ] ], "additional_components": [ "DDB_G0290551", "Q54FX2", "DDB_G0290551", "Q54W95", "DDB_G0279813" ] }, "reaction_10583358": { "compartment": "compartment_7660", "id": "reaction_10583358", "reactome": "R-DDI-113504", "name": "Detection of damage during initiation of DNA synthesis in S-phase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577245" ], "products": [ "species_10576604", "species_113656" ], "modifiers": [], "additional_components": [ "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731", "Q54SV8", "DDB_G0282191", "Q54MM7", "DDB_G0285853", "Q55BM5", "DDB_G0270442", "Q54S08", "DDB_G0282731" ] }, "reaction_10627090": { "compartment": "compartment_70101", "id": "reaction_10627090", "reactome": "R-DDI-9659820", "name": "RB1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627088" ], "products": [ "species_10577547" ], "modifiers": [], "additional_components": [ "DDB_G0290551", "DDB_G0290551" ] }, "reaction_10625026": { "compartment": "compartment_7660", "id": "reaction_10625026", "reactome": "R-DDI-9018017", "name": "RB1 binds and inhibits E2F1/2/3:DP1/2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577547", "species_10602086" ], "products": [ "species_10625024" ], "modifiers": [ [ "species_10577271", "inhibitor" ] ], "additional_components": [ "DDB_G0290551", "Q54Q23", "DDB_G0284129", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "Q7KWP1", "DDB_G0276799", "Q54FX2", "DDB_G0290551", "Q8T2F2", "DDB_G0277439", "P42524", "DDB_G0275493", "P34112", "DDB_G0272813" ] }, "reaction_10597553": { "compartment": "compartment_7660", "id": "reaction_10597553", "reactome": "R-DDI-1363274", "name": "Dephosphorylation of p107 (RBL1) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10597263" ], "products": [ "species_113550", "species_10597255" ], "modifiers": [ [ "species_10597550", "catalyst" ] ], "additional_components": [ "DDB_G0290551", "DDB_G0290551" ] }, "reaction_10597584": { "compartment": "compartment_7660", "id": "reaction_10597584", "reactome": "R-DDI-1363331", "name": "Ubiquitination of p130 (RBL2) by SCF (Skp2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597577", "species_10576865" ], "products": [ "species_10597581", "species_10585908" ], "modifiers": [ [ "species_10597577", "catalyst" ] ], "additional_components": [ "Q54FX2", "DDB_G0290551", "B0G102", "DDB_G0271642", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54FX2", "DDB_G0290551", "B0G102", "DDB_G0271642", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54FX2", "DDB_G0290551", "B0G102", "DDB_G0271642", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972" ] }, "reaction_10597555": { "compartment": "compartment_7660", "id": "reaction_10597555", "reactome": "R-DDI-1363276", "name": "Dephosphorylation of p130 (RBL2) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10597251" ], "products": [ "species_113550", "species_10597229" ], "modifiers": [ [ "species_10597550", "catalyst" ] ], "additional_components": [ "DDB_G0290551", "DDB_G0290551" ] }, "reaction_10597579": { "compartment": "compartment_7660", "id": "reaction_10597579", "reactome": "R-DDI-1363328", "name": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585908", "species_10597251" ], "products": [ "species_10597577" ], "modifiers": [], "additional_components": [ "B0G102", "DDB_G0271642", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "DDB_G0290551", "Q54FX2", "DDB_G0290551", "B0G102", "DDB_G0271642", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972" ] }, "reaction_10600926": { "compartment": "compartment_984", "id": "reaction_10600926", "reactome": "R-DDI-2396337", "name": "HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10600922", "species_10598295" ], "products": [ "species_10600924" ], "modifiers": [], "additional_components": [ "Q54LD6", "DDB_G0286691", "DDB_G0270488", "Q55E77", "DDB_G0270488", "Q54LD6", "DDB_G0286691" ] }, "reaction_10603454": { "compartment": "compartment_984", "id": "reaction_10603454", "reactome": "R-DDI-4084505", "name": "Laminins bind HSPG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603450", "species_10598295" ], "products": [ "species_10603452" ], "modifiers": [], "additional_components": [ "Q55E77", "DDB_G0270488", "DDB_G0270488", "Q55E77", "DDB_G0270488" ] }, "reaction_10626256": { "compartment": "compartment_876", "id": "reaction_10626256", "reactome": "R-DDI-9625814", "name": "SPHK1 phosphorylates sphingosine in response to E2 stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1606609" ], "products": [ "species_5218688" ], "modifiers": [ [ "species_10590508", "catalyst" ] ], "additional_components": [ "DDB_G0284545" ] }, "reaction_10582777": { "compartment": "compartment_7660", "id": "reaction_10582777", "reactome": "R-DDI-110322", "name": "Formation of Pol zeta complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582773", "species_10582768" ], "products": [ "species_10582775" ], "modifiers": [], "additional_components": [ "DDB_G0282747", "DDB_G0271608", "Q55AZ3", "DDB_G0271608", "Q54S00", "DDB_G0282747" ] }, "reaction_10594097": { "compartment": "compartment_70101", "id": "reaction_10594097", "reactome": "R-DDI-727767", "name": "SLC29A3 transports nucleosides from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727746" ], "products": [ "species_727782" ], "modifiers": [ [ "species_10594084", "catalyst" ] ], "additional_components": [ "species_83909", "species_83921", "CHEBI:16750", "CHEBI:16704", "species_83928", "CHEBI:17562", "species_5635947", "species_83909", "species_83921", "CHEBI:16704", "CHEBI:16750", "CHEBI:17562", "species_83928", "species_5635947", "Q54TT2", "DDB_G0283439", "Q54TT3", "DDB_G0283439", "Q54R17", "DDB_G0283439" ] }, "reaction_10594099": { "compartment": "compartment_70101", "id": "reaction_10594099", "reactome": "R-DDI-727768", "name": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727737" ], "products": [ "species_727774" ], "modifiers": [ [ "species_10594073", "catalyst" ] ], "additional_components": [ "species_159362", "CHEBI:28918", "species_83909", "species_209914", "species_209789", "species_209789", "species_83909", "species_209914", "species_159362", "CHEBI:28918", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0283439", "Q54TT3", "DDB_G0283439" ] }, "reaction_10582532": { "compartment": "compartment_70101", "id": "reaction_10582532", "reactome": "R-DDI-109534", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179743" ], "products": [ "species_179737" ], "modifiers": [ [ "species_10582529", "catalyst" ] ], "additional_components": [ "species_83909", "species_83921", "CHEBI:16750", "CHEBI:16704", "species_83928", "CHEBI:17562", "species_83921", "CHEBI:16750", "CHEBI:16704", "species_83928", "species_83909", "CHEBI:17562", "Q54R17", "DDB_G0283439" ] }, "reaction_10582534": { "compartment": "compartment_70101", "id": "reaction_10582534", "reactome": "R-DDI-109536", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179737" ], "products": [ "species_179743" ], "modifiers": [ [ "species_10582529", "catalyst" ] ], "additional_components": [ "species_83921", "CHEBI:16750", "CHEBI:16704", "species_83928", "species_83909", "CHEBI:17562", "species_83909", "species_83921", "CHEBI:16750", "CHEBI:16704", "species_83928", "CHEBI:17562", "Q54R17", "DDB_G0283439" ] }, "reaction_10584043": { "compartment": "compartment_70616", "id": "reaction_10584043", "reactome": "R-DDI-163215", "name": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_113593" ], "products": [ "species_113581", "species_113592" ], "modifiers": [ [ "species_10584040", "catalyst" ] ], "additional_components": [ "O97470", "DDB_G0267454" ] }, "reaction_10582525": { "compartment": "compartment_70101", "id": "reaction_10582525", "reactome": "R-DDI-109527", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179747" ], "products": [ "species_179742" ], "modifiers": [ [ "species_10582522", "catalyst" ] ], "additional_components": [ "species_83921", "CHEBI:16750", "species_83956", "CHEBI:16704", "species_83928", "species_113599", "species_83909", "species_83960", "species_29554", "species_5635947", "CHEBI:17562", "CHEBI:16040", "species_83909", "CHEBI:16040", "species_83956", "species_83921", "CHEBI:16750", "CHEBI:16704", "species_83928", "species_83960", "species_29554", "CHEBI:17562", "species_5635947", "species_113599", "Q54TT3", "DDB_G0283439", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0283439" ] }, "reaction_10594076": { "compartment": "compartment_70101", "id": "reaction_10594076", "reactome": "R-DDI-727740", "name": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727774" ], "products": [ "species_727737" ], "modifiers": [ [ "species_10594073", "catalyst" ] ], "additional_components": [ "species_209789", "species_83909", "species_209914", "species_159362", "CHEBI:28918", "species_159362", "CHEBI:28918", "species_83909", "species_209914", "species_209789", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0283439", "Q54TT3", "DDB_G0283439" ] }, "reaction_10582527": { "compartment": "compartment_70101", "id": "reaction_10582527", "reactome": "R-DDI-109529", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179742" ], "products": [ "species_179747" ], "modifiers": [ [ "species_10582522", "catalyst" ] ], "additional_components": [ "species_83909", "CHEBI:16040", "species_83956", "species_83921", "CHEBI:16750", "CHEBI:16704", "species_83928", "species_83960", "species_29554", "CHEBI:17562", "species_5635947", "species_113599", "species_83921", "CHEBI:16750", "species_83956", "CHEBI:16704", "species_83928", "species_113599", "species_83909", "species_83960", "species_29554", "species_5635947", "CHEBI:17562", "CHEBI:16040", "Q54TT3", "DDB_G0283439", "Q54R17", "DDB_G0283439", "Q54TT2", "DDB_G0283439" ] }, "reaction_10594129": { "compartment": "compartment_20699", "id": "reaction_10594129", "reactome": "R-DDI-742354", "name": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162756" ], "products": [ "species_914003" ], "modifiers": [ [ "species_10594126", "catalyst" ] ], "additional_components": [ "DDB_G0275061" ] }, "reaction_10594132": { "compartment": "compartment_20699", "id": "reaction_10594132", "reactome": "R-DDI-742373", "name": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742353" ], "products": [ "species_742361" ], "modifiers": [ [ "species_10594126", "catalyst" ] ], "additional_components": [ "DDB_G0275061" ] }, "reaction_10594095": { "compartment": "compartment_20699", "id": "reaction_10594095", "reactome": "R-DDI-727759", "name": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183" ], "products": [ "species_727753" ], "modifiers": [ [ "species_10594092", "catalyst" ] ], "additional_components": [ "DDB_G0278059" ] }, "reaction_10620690": { "compartment": "compartment_876", "id": "reaction_10620690", "reactome": "R-DDI-8870354", "name": "SLC36A4 transports extracellular L-Pro to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352033" ], "products": [ "species_113538" ], "modifiers": [ [ "species_10620684", "catalyst" ] ], "additional_components": [ "DDB_G0293074" ] }, "reaction_10589664": { "compartment": "compartment_876", "id": "reaction_10589664", "reactome": "R-DDI-375768", "name": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10589661", "catalyst" ] ], "additional_components": [ "species_29444", "species_29468", "species_29468", "species_29444", "Q54KK4", "DDB_G0346922", "Q54F04", "DDB_G0346922", "Q54KK2", "DDB_G0346922", "Q54KK5", "DDB_G0346922", "Q54W03", "DDB_G0346922", "Q54EJ9", "DDB_G0291227", "Q54KK3", "DDB_G0346922" ] }, "reaction_10589683": { "compartment": "compartment_876", "id": "reaction_10589683", "reactome": "R-DDI-375770", "name": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10589680", "catalyst" ] ], "additional_components": [ "species_29444", "species_29468", "species_29468", "species_29444", "Q54EJ9", "DDB_G0291227", "Q54F04", "DDB_G0346922", "Q54KK2", "DDB_G0346922", "Q54KK3", "DDB_G0346922", "Q54KK4", "DDB_G0346922", "Q54KK5", "DDB_G0346922", "Q54W03", "DDB_G0346922" ] }, "reaction_10589702": { "compartment": "compartment_876", "id": "reaction_10589702", "reactome": "R-DDI-375776", "name": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10589699", "catalyst" ] ], "additional_components": [ "species_29444", "species_29468", "species_29468", "species_29444", "Q54W03", "DDB_G0346922", "Q54EJ9", "DDB_G0291227", "Q54F04", "DDB_G0346922", "Q54KK2", "DDB_G0346922", "Q54KK3", "DDB_G0346922", "Q54KK4", "DDB_G0346922", "Q54KK5", "DDB_G0346922" ] }, "reaction_10589704": { "compartment": "compartment_876", "id": "reaction_10589704", "reactome": "R-DDI-375790", "name": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10589661", "catalyst" ] ], "additional_components": [ "species_29444", "species_29468", "species_29468", "species_29444", "Q54KK4", "DDB_G0346922", "Q54F04", "DDB_G0346922", "Q54KK2", "DDB_G0346922", "Q54KK5", "DDB_G0346922", "Q54W03", "DDB_G0346922", "Q54EJ9", "DDB_G0291227", "Q54KK3", "DDB_G0346922" ] }, "reaction_10624530": { "compartment": "compartment_7660", "id": "reaction_10624530", "reactome": "R-DDI-9007539", "name": "CHEK1 phosphorylates E2F6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10623848" ], "products": [ "species_113582", "species_10624528" ], "modifiers": [ [ "species_10577605", "catalyst" ] ], "additional_components": [ "DDB_G0284129", "DDB_G0284129", "DDB_G0279719" ] }, "reaction_10623920": { "compartment": "compartment_7660", "id": "reaction_10623920", "reactome": "R-DDI-8954056", "name": "E2F6 binds TFDP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10597242", "species_10623848" ], "products": [ "species_10623918" ], "modifiers": [], "additional_components": [ "DDB_G0276799", "DDB_G0284129", "Q54Q23", "DDB_G0284129", "Q7KWP1", "DDB_G0276799" ] }, "reaction_10623931": { "compartment": "compartment_7660", "id": "reaction_10623931", "reactome": "R-DDI-8954117", "name": "E2F6:TFDP1 binds EPC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623850", "species_10623927" ], "products": [ "species_10623929" ], "modifiers": [], "additional_components": [ "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129", "DDB_G0287727", "Q54JZ0", "DDB_G0287727", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129" ] }, "reaction_10623852": { "compartment": "compartment_7660", "id": "reaction_10623852", "reactome": "R-DDI-8953111", "name": "E2F6 binds TFDP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623848", "species_10597240" ], "products": [ "species_10623850" ], "modifiers": [], "additional_components": [ "DDB_G0284129", "DDB_G0276799", "Q7KWP1", "DDB_G0276799", "Q54Q23", "DDB_G0284129" ] }, "reaction_10595753": { "compartment": "compartment_7660", "id": "reaction_10595753", "reactome": "R-DDI-975040", "name": "KRAB-ZNF / KAP Interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10595749", "species_10595441" ], "products": [ "species_10595751" ], "modifiers": [], "additional_components": [ "Q54UG9", "DDB_G0281085", "DDB_G0285989", "Q54MF7", "DDB_G0285989", "Q54UG9", "DDB_G0281085" ] }, "reaction_10612161": { "compartment": "compartment_7660", "id": "reaction_10612161", "reactome": "R-DDI-5696655", "name": "PARP1 or PARP2 PARylates DDB2 and autoPARylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612159", "species_427523" ], "products": [ "species_427497", "species_10611122" ], "modifiers": [], "additional_components": [ "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296", "Q54CS2", "DDB_G0292794", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820" ] }, "reaction_10612163": { "compartment": "compartment_7660", "id": "reaction_10612163", "reactome": "R-DDI-5696664", "name": "PARP1 or PARP2 binds DDB2 at GG-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612157", "species_10606233" ], "products": [ "species_10612159" ], "modifiers": [], "additional_components": [ "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296" ] }, "reaction_10611143": { "compartment": "compartment_7660", "id": "reaction_10611143", "reactome": "R-DDI-5691004", "name": "XPC binds RAD23 and CETN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603915", "species_10603976", "species_10611111" ], "products": [ "species_10611141" ], "modifiers": [], "additional_components": [ "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "DDB_G0292296", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q1ZXA6", "DDB_G0292296", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151" ] }, "reaction_10612471": { "compartment": "compartment_7660", "id": "reaction_10612471", "reactome": "R-DDI-6782943", "name": "UV-DDB ubiquitinates XPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611197", "species_10576865" ], "products": [ "species_10612157" ], "modifiers": [ [ "species_10611197", "catalyst" ] ], "additional_components": [ "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q1ZXA6", "DDB_G0292296", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q1ZXA6", "DDB_G0292296", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629" ] }, "reaction_10611199": { "compartment": "compartment_7660", "id": "reaction_10611199", "reactome": "R-DDI-5691006", "name": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611195", "species_10611141", "species_5688114" ], "products": [ "species_10611197", "species_10611193" ], "modifiers": [], "additional_components": [ "Q54PF3", "DDB_G0284597", "Q54QX3", "DDB_G0283587", "Q54HL6", "DDB_G0289361", "Q55BD5", "DDB_G0271282", "Q54E53", "DDB_G0291848", "Q54C92", "DDB_G0293180", "Q75K24", "DDB_G0275471", "Q54B82", "DDB_G0293844", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q1ZXA6", "DDB_G0292296", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q1ZXA6", "DDB_G0292296", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "Q54CS2", "DDB_G0292794", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54PF3", "DDB_G0284597", "Q54QX3", "DDB_G0283587", "Q54HL6", "DDB_G0289361", "Q55BD5", "DDB_G0271282", "Q54E53", "DDB_G0291848", "Q54C92", "DDB_G0293180", "Q75K24", "DDB_G0275471", "Q54B82", "DDB_G0293844" ] }, "reaction_10611139": { "compartment": "compartment_7660", "id": "reaction_10611139", "reactome": "R-DDI-5691000", "name": "TFIIH binds GG-NER site to form a verification complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580699", "species_10611122" ], "products": [ "species_10611137" ], "modifiers": [], "additional_components": [ "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54CS2", "DDB_G0292794", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729" ] }, "reaction_10582642": { "compartment": "compartment_7660", "id": "reaction_10582642", "reactome": "R-DDI-109955", "name": "Formation of ERCC1:XPF heterodimeric complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582638", "species_10582633" ], "products": [ "species_10582640" ], "modifiers": [], "additional_components": [ "DDB_G0284419", "DDB_G0267682", "Q55GG6", "DDB_G0267682", "Q54PN5", "DDB_G0284419" ] }, "reaction_10612919": { "compartment": "compartment_7660", "id": "reaction_10612919", "reactome": "R-DDI-6790454", "name": "SUMOylation of XPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611132", "species_10612903" ], "products": [ "species_10601725", "species_10612914" ], "modifiers": [ [ "species_10612916", "catalyst" ] ], "additional_components": [ "O00835", "DDB_G0278729", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "Q55CT8", "DDB_G0269906", "Q55G81", "DDB_G0267414", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296", "Q9NGP4", "DDB_G0287693", "Q54KR7", "DDB_G0287153", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296", "Q54SX2", "DDB_G0282161", "Q8N0B4", "DDB_G0286189", "Q55FZ7", "DDB_G0267886", "O00835", "DDB_G0278729", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "Q55CT8", "DDB_G0269906", "Q55G81", "DDB_G0267414", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q54CS2", "DDB_G0292794", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820" ] }, "reaction_10611135": { "compartment": "compartment_7660", "id": "reaction_10611135", "reactome": "R-DDI-5690996", "name": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611128" ], "products": [ "species_113550", "species_113582", "species_10611132" ], "modifiers": [ [ "species_10611128", "catalyst" ] ], "additional_components": [ "O00835", "DDB_G0278729", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "Q55CT8", "DDB_G0269906", "Q55G81", "DDB_G0267414", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q54CS2", "DDB_G0292794", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820", "O00835", "DDB_G0278729", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "Q55CT8", "DDB_G0269906", "Q55G81", "DDB_G0267414", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820", "Q54CS2", "DDB_G0292794", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296", "O00835", "DDB_G0278729", "Q86IB5", "DDB_G0275517", "Q55FP1", "DDB_G0268014", "Q55CT8", "DDB_G0269906", "Q55G81", "DDB_G0267414", "Q86KZ2", "DDB_G0272362", "Q54C29", "DDB_G0293228", "Q54CS2", "DDB_G0292794", "Q54K33", "DDB_G0287629", "B0M0P5", "DDB_G0286013", "Q54LV1", "DDB_G0286357", "Q54WU9", "DDB_G0279421", "Q869L7", "DDB_G0279421", "Q54IY3", "DDB_G0288427", "Q54X77", "DDB_G0279151", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q1ZXA6", "DDB_G0292296", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820" ] }, "reaction_10611950": { "compartment": "compartment_7660", "id": "reaction_10611950", "reactome": "R-DDI-5696465", "name": "USP45 deubiquitinates ERCC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10611945" ], "products": [ "species_10582633", "species_10576865" ], "modifiers": [ [ "species_10611947", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55GG6", "DDB_G0267682", "DDB_G0267682", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0274207" ] }, "reaction_10612448": { "compartment": "compartment_7660", "id": "reaction_10612448", "reactome": "R-DDI-6782208", "name": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10612443" ], "products": [ "species_10612445", "species_113541" ], "modifiers": [ [ "species_10612443", "catalyst" ] ], "additional_components": [ "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54TY2", "DDB_G0281441", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "Q54KS3", "DDB_G0287149", "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MD4", "DDB_G0286027", "Q54MH9", "DDB_G0285961", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54TY2", "DDB_G0281441", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "Q54KS3", "DDB_G0287149", "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MD4", "DDB_G0286027", "Q54MH9", "DDB_G0285961", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54TY2", "DDB_G0281441", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "Q54KS3", "DDB_G0287149", "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MD4", "DDB_G0286027", "Q54MH9", "DDB_G0285961", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677" ] }, "reaction_10612419": { "compartment": "compartment_7660", "id": "reaction_10612419", "reactome": "R-DDI-6782141", "name": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612415", "species_10582640" ], "products": [ "species_10612417" ], "modifiers": [], "additional_components": [ "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54TY2", "DDB_G0281441", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q55GG6", "DDB_G0267682", "Q54PN5", "DDB_G0284419", "Q55GG6", "DDB_G0267682", "Q54PN5", "DDB_G0284419", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54TY2", "DDB_G0281441", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10627351": { "compartment": "compartment_7660", "id": "reaction_10627351", "reactome": "R-DDI-9684118", "name": "ERCC3-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10612392" ], "products": [ "species_113550", "species_113582", "species_10612403" ], "modifiers": [ [ "species_10612392", "catalyst" ] ], "additional_components": [ "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54TY2", "DDB_G0281441", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54TY2", "DDB_G0281441", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54TY2", "DDB_G0281441", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10612424": { "compartment": "compartment_7660", "id": "reaction_10612424", "reactome": "R-DDI-6782204", "name": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612417" ], "products": [ "species_10612421" ], "modifiers": [ [ "species_10612417", "catalyst" ] ], "additional_components": [ "Q55GG6", "DDB_G0267682", "Q54PN5", "DDB_G0284419", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54TY2", "DDB_G0281441", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q869U4", "DDB_G0276443", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q55GG6", "DDB_G0267682", "Q54PN5", "DDB_G0284419", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54TY2", "DDB_G0281441", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q55GG6", "DDB_G0267682", "Q54PN5", "DDB_G0284419", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54TY2", "DDB_G0281441", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10612456": { "compartment": "compartment_7660", "id": "reaction_10612456", "reactome": "R-DDI-6782211", "name": "DNA polymerases delta, epsilon or kappa bind the TC-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577420", "species_10612452", "species_10612421", "species_10612450" ], "products": [ "species_10612454" ], "modifiers": [], "additional_components": [ "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MD4", "DDB_G0286027", "Q54MH9", "DDB_G0285961", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K47", "DDB_G0287607", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q869U4", "DDB_G0276443", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q55GG6", "DDB_G0267682", "Q54PN5", "DDB_G0284419", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54TY2", "DDB_G0281441", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54KS3", "DDB_G0287149", "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q869U4", "DDB_G0276443", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q55GG6", "DDB_G0267682", "Q54PN5", "DDB_G0284419", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54K47", "DDB_G0287607", "Q54KS3", "DDB_G0287149", "Q54N97", "DDB_G0285381", "Q54TN8", "DDB_G0281641", "B0G131", "DDB_G0294609", "Q54BN3", "DDB_G0293702", "Q54E21", "DDB_G0291868", "Q54ST4", "DDB_G0282235", "Q54MD4", "DDB_G0286027", "Q54MH9", "DDB_G0285961", "Q54TY2", "DDB_G0281441", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10612395": { "compartment": "compartment_7660", "id": "reaction_10612395", "reactome": "R-DDI-6782131", "name": "ERCC2-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10612381" ], "products": [ "species_113550", "species_113582", "species_10612392" ], "modifiers": [ [ "species_10612381", "catalyst" ] ], "additional_components": [ "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54TY2", "DDB_G0281441", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54TY2", "DDB_G0281441", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q54X62", "DDB_G0279177", "Q7KWK5", "DDB_G0276803", "Q555Z2", "DDB_G0274797", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q54N41", "DDB_G0285521", "Q54Z08", "DDB_G0277977", "Q54CS2", "DDB_G0292794", "Q551N8", "DDB_G0276481", "B0M0P5", "DDB_G0286013", "Q54K33", "DDB_G0287629", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "P35084", "DDB_G0279193", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54TY2", "DDB_G0281441", "Q869U4", "DDB_G0276443", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10581574": { "compartment": "compartment_7660", "id": "reaction_10581574", "reactome": "R-DDI-75172", "name": "Formation of RAD50:MRE11 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581565", "species_10581570" ], "products": [ "species_10581572" ], "modifiers": [], "additional_components": [ "DDB_G0292786", "DDB_G0293546", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786" ] }, "reaction_10611351": { "compartment": "compartment_7660", "id": "reaction_10611351", "reactome": "R-DDI-5693536", "name": "ATM phosphorylates MDC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611348" ], "products": [ "species_113582", "species_10608053" ], "modifiers": [ [ "species_10611348", "catalyst" ] ], "additional_components": [ "Q86IG6", "DDB_G0272690", "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54Z32", "DDB_G0278587", "Q54F38", "DDB_G0291185", "Q54HV7", "DDB_G0289197", "Q76NW2", "DDB_G0276863", "Q86IG6", "DDB_G0272690", "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54Z32", "DDB_G0278587", "Q54F38", "DDB_G0291185", "Q54HV7", "DDB_G0289197", "Q76NW2", "DDB_G0276863", "Q86IG6", "DDB_G0272690", "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54Z32", "DDB_G0278587", "Q54F38", "DDB_G0291185", "Q54HV7", "DDB_G0289197", "Q76NW2", "DDB_G0276863" ] }, "reaction_10611386": { "compartment": "compartment_7660", "id": "reaction_10611386", "reactome": "R-DDI-5693583", "name": "MDC1 associates with gamma-H2AFX at nuclear foci", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10608042", "species_10611346" ], "products": [ "species_10611348" ], "modifiers": [], "additional_components": [ "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54Z32", "DDB_G0278587", "Q54F38", "DDB_G0291185", "Q54HV7", "DDB_G0289197", "Q76NW2", "DDB_G0276863", "Q86IG6", "DDB_G0272690", "Q86IG6", "DDB_G0272690", "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54Z32", "DDB_G0278587", "Q54F38", "DDB_G0291185", "Q54HV7", "DDB_G0289197", "Q76NW2", "DDB_G0276863" ] }, "reaction_10611356": { "compartment": "compartment_7660", "id": "reaction_10611356", "reactome": "R-DDI-5693549", "name": "ATM phosphorylates histone H2AFX on S139 at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10611353" ], "products": [ "species_113582", "species_10608103" ], "modifiers": [ [ "species_10611353", "catalyst" ] ], "additional_components": [ "Q54Z32", "DDB_G0278587", "Q54F38", "DDB_G0291185", "Q76NW2", "DDB_G0276863", "Q54HV7", "DDB_G0289197", "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786", "Q54Z32", "DDB_G0278587", "Q54F38", "DDB_G0291185", "Q54HV7", "DDB_G0289197", "Q76NW2", "DDB_G0276863", "Q54Z32", "DDB_G0278587", "Q54F38", "DDB_G0291185", "Q76NW2", "DDB_G0276863", "Q54HV7", "DDB_G0289197", "B0G130", "DDB_G0279699", "Q54BN2", "DDB_G0293546", "Q54CS9", "DDB_G0292786" ] }, "reaction_10627073": { "compartment": "compartment_70101", "id": "reaction_10627073", "reactome": "R-DDI-9656947", "name": "OGG1beta translocates to mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627069" ], "products": [ "species_10627071" ], "modifiers": [], "additional_components": [ "DDB_G0292618", "DDB_G0292618" ] }, "reaction_10580816": { "compartment": "compartment_7660", "id": "reaction_10580816", "reactome": "R-DDI-73931", "name": "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580809" ], "products": [ "species_10580813" ], "modifiers": [ [ "species_10580809", "catalyst" ] ], "additional_components": [ "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713" ] }, "reaction_10582803": { "compartment": "compartment_7660", "id": "reaction_10582803", "reactome": "R-DDI-110360", "name": "Recruitment of POLB to the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582796", "species_10580793" ], "products": [ "species_10582801" ], "modifiers": [], "additional_components": [ "P51173", "DDB_G0277701", "DDB_G0284713", "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701" ] }, "reaction_10582806": { "compartment": "compartment_7660", "id": "reaction_10582806", "reactome": "R-DDI-110375", "name": "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582801" ], "products": [ "species_10582782", "species_10580820", "species_30977" ], "modifiers": [ [ "species_10582801", "catalyst" ] ], "additional_components": [ "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701", "DDB_G0277701", "Q1ZXF2", "DDB_G0284713", "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701" ] }, "reaction_10580825": { "compartment": "compartment_7660", "id": "reaction_10580825", "reactome": "R-DDI-73932", "name": "Resynthesis of excised residue by POLB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10580822" ], "products": [ "species_10580809", "species_113541" ], "modifiers": [ [ "species_10580822", "catalyst" ] ], "additional_components": [ "Q1ZXF2", "DDB_G0284713", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713", "Q1ZXF2", "DDB_G0284713", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857" ] }, "reaction_10582808": { "compartment": "compartment_7660", "id": "reaction_10582808", "reactome": "R-DDI-110376", "name": "Recruitment of LIG3:XRCC1 complex to the site of repair by POLB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580807", "species_10580820" ], "products": [ "species_10580822" ], "modifiers": [], "additional_components": [ "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713", "Q1ZXF2", "DDB_G0284713", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857" ] }, "reaction_10582786": { "compartment": "compartment_7660", "id": "reaction_10582786", "reactome": "R-DDI-110349", "name": "Displacement of UNG glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582782", "species_10582688" ], "products": [ "species_10582682", "species_10582784" ], "modifiers": [], "additional_components": [ "DDB_G0277701", "P53766", "DDB_G0277877", "DDB_G0277877", "P51173", "DDB_G0277701" ] }, "reaction_10582788": { "compartment": "compartment_7660", "id": "reaction_10582788", "reactome": "R-DDI-110352", "name": "Displacement of NTHL1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582782", "species_10582704" ], "products": [ "species_10582675", "species_10582784" ], "modifiers": [], "additional_components": [ "DDB_G0277701", "Q86K43", "DDB_G0277247", "DDB_G0277247", "P51173", "DDB_G0277701" ] }, "reaction_10582790": { "compartment": "compartment_7660", "id": "reaction_10582790", "reactome": "R-DDI-110354", "name": "Displacement of OGG1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582782", "species_10582739" ], "products": [ "species_10582733", "species_10582784" ], "modifiers": [], "additional_components": [ "DDB_G0277701", "Q54CZ3", "DDB_G0292618", "DDB_G0292618", "P51173", "DDB_G0277701" ] }, "reaction_10582792": { "compartment": "compartment_7660", "id": "reaction_10582792", "reactome": "R-DDI-110355", "name": "Displacement of MUTYH glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582782", "species_10582760" ], "products": [ "species_10582754", "species_10582784" ], "modifiers": [], "additional_components": [ "DDB_G0277701", "Q1ZXP7", "DDB_G0270764", "DDB_G0270764", "P51173", "DDB_G0277701" ] }, "reaction_10606194": { "compartment": "compartment_7660", "id": "reaction_10606194", "reactome": "R-DDI-5649734", "name": "LIG3 ligates NEIL1,NEIL2-generated single strand break", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606186" ], "products": [ "species_10606191" ], "modifiers": [ [ "species_10606186", "catalyst" ] ], "additional_components": [ "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713" ] }, "reaction_10606184": { "compartment": "compartment_7660", "id": "reaction_10606184", "reactome": "R-DDI-5649705", "name": "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10606179" ], "products": [ "species_113550", "species_10606181" ], "modifiers": [ [ "species_10606179", "catalyst" ] ], "additional_components": [ "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713" ] }, "reaction_10606189": { "compartment": "compartment_7660", "id": "reaction_10606189", "reactome": "R-DDI-5649723", "name": "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10606181" ], "products": [ "species_10606186", "species_113541" ], "modifiers": [ [ "species_10606181", "catalyst" ] ], "additional_components": [ "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713", "Q54U78", "DDB_G0281229", "Q86H44", "DDB_G0275653", "Q54QM4", "DDB_G0283857", "Q1ZXF2", "DDB_G0284713" ] }, "reaction_10606225": { "compartment": "compartment_7660", "id": "reaction_10606225", "reactome": "R-DDI-5649854", "name": "Recruitment of POLB to oxidatively damaged AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582815", "species_10580793" ], "products": [ "species_10582817" ], "modifiers": [], "additional_components": [ "P51173", "DDB_G0277701", "DDB_G0284713", "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701" ] }, "reaction_10606227": { "compartment": "compartment_7660", "id": "reaction_10606227", "reactome": "R-DDI-5649856", "name": "Oxidative damage to the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582796" ], "products": [ "species_10582815" ], "modifiers": [], "additional_components": [ "P51173", "DDB_G0277701", "P51173", "DDB_G0277701" ] }, "reaction_10606288": { "compartment": "compartment_7660", "id": "reaction_10606288", "reactome": "R-DDI-5651739", "name": "PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606281" ], "products": [ "species_10606286", "species_10606279" ], "modifiers": [], "additional_components": [ "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820", "Q1ZXF2", "DDB_G0284713", "Q54NU0", "DDB_G0284987", "Q1ZXF2", "DDB_G0284713", "Q54NU0", "DDB_G0284987", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820" ] }, "reaction_10606304": { "compartment": "compartment_7660", "id": "reaction_10606304", "reactome": "R-DDI-5651828", "name": "PARG dePARylates PARP1,PARP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10606279" ], "products": [ "species_5651834", "species_10606233" ], "modifiers": [ [ "species_10606240", "catalyst" ] ], "additional_components": [ "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "DDB_G0277943" ] }, "reaction_10606242": { "compartment": "compartment_7660", "id": "reaction_10606242", "reactome": "R-DDI-5649873", "name": "PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577480", "species_10606233", "species_10582821" ], "products": [ "species_10582782", "species_10606235" ], "modifiers": [ [ "species_10606240", "catalyst" ] ], "additional_components": [ "DDB_G0284987", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701", "DDB_G0277701", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q1ZXF2", "DDB_G0284713", "Q54NU0", "DDB_G0284987", "DDB_G0277943" ] }, "reaction_10606296": { "compartment": "compartment_7660", "id": "reaction_10606296", "reactome": "R-DDI-5651773", "name": "LIG1 binds POLB at long-patch BER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606292", "species_10577488" ], "products": [ "species_10606294" ], "modifiers": [], "additional_components": [ "Q1ZXF2", "DDB_G0284713", "DDB_G0274493", "Q869E1", "DDB_G0274493", "Q1ZXF2", "DDB_G0284713" ] }, "reaction_10606250": { "compartment": "compartment_7660", "id": "reaction_10606250", "reactome": "R-DDI-5649883", "name": "POLB-mediated DNA strand displacement synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10606235" ], "products": [ "species_10606247", "species_113541" ], "modifiers": [ [ "species_10606235", "catalyst" ] ], "additional_components": [ "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q1ZXF2", "DDB_G0284713", "Q54NU0", "DDB_G0284987", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q1ZXF2", "DDB_G0284713", "Q54NU0", "DDB_G0284987", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q1ZXF2", "DDB_G0284713", "Q54NU0", "DDB_G0284987" ] }, "reaction_10606301": { "compartment": "compartment_7660", "id": "reaction_10606301", "reactome": "R-DDI-5651789", "name": "LIG1 bound to POLB ligates SSB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606294" ], "products": [ "species_10606298" ], "modifiers": [ [ "species_10606294", "catalyst" ] ], "additional_components": [ "Q869E1", "DDB_G0274493", "Q1ZXF2", "DDB_G0284713", "Q869E1", "DDB_G0274493", "Q1ZXF2", "DDB_G0284713", "Q869E1", "DDB_G0274493", "Q1ZXF2", "DDB_G0284713" ] }, "reaction_10606284": { "compartment": "compartment_7660", "id": "reaction_10606284", "reactome": "R-DDI-5651723", "name": "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606247", "species_427523" ], "products": [ "species_427497", "species_10606281" ], "modifiers": [ [ "species_10606247", "catalyst" ] ], "additional_components": [ "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q1ZXF2", "DDB_G0284713", "Q54NU0", "DDB_G0284987", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q54XI2", "DDB_G0278741", "Q55GU8", "DDB_G0267468", "Q8I7C6", "DDB_G0292820", "Q1ZXF2", "DDB_G0284713", "Q54NU0", "DDB_G0284987", "Q55GU8", "DDB_G0267468", "Q54HY5", "DDB_G0289141", "Q54X55", "DDB_G0279195", "Q8I7C6", "DDB_G0292820", "Q54XI2", "DDB_G0278741", "Q1ZXF2", "DDB_G0284713", "Q54NU0", "DDB_G0284987" ] }, "reaction_10582824": { "compartment": "compartment_7660", "id": "reaction_10582824", "reactome": "R-DDI-111253", "name": "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10582817" ], "products": [ "species_10582821", "species_113541" ], "modifiers": [ [ "species_10582817", "catalyst" ] ], "additional_components": [ "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701", "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701", "Q1ZXF2", "DDB_G0284713", "P51173", "DDB_G0277701" ] }, "reaction_10582799": { "compartment": "compartment_7660", "id": "reaction_10582799", "reactome": "R-DDI-110359", "name": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582784" ], "products": [ "species_10582796" ], "modifiers": [ [ "species_10582784", "catalyst" ] ], "additional_components": [ "P51173", "DDB_G0277701", "P51173", "DDB_G0277701", "P51173", "DDB_G0277701" ] }, "reaction_10626280": { "compartment": "compartment_876", "id": "reaction_10626280", "reactome": "R-DDI-9634834", "name": "ACHEIs bind ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9634838", "species_10589588" ], "products": [ "species_10589591" ], "modifiers": [], "additional_components": [ "Q54ET7", "DDB_G0291344", "Q86L18", "DDB_G0291344", "P18142", "DDB_G0283085", "Q54N21", "DDB_G0291344", "Q54WD8", "DDB_G0291344", "P21837", "DDB_G0285419", "Q54ET7", "DDB_G0291344", "Q86L18", "DDB_G0291344", "P18142", "DDB_G0283085", "Q54N21", "DDB_G0291344", "Q54WD8", "DDB_G0291344", "P21837", "DDB_G0285419" ] }, "reaction_10588771": { "compartment": "compartment_70101", "id": "reaction_10588771", "reactome": "R-DDI-210444", "name": "L-Glutamate loading of synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_10588768" ], "products": [ "species_10588746" ], "modifiers": [ [ "species_10588768", "catalyst" ] ], "additional_components": [ "Q54W37", "DDB_G0280761", "Q54UX4", "DDB_G0280761", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q1ZXE7", "DDB_G0286169", "P20790", "DDB_G0280043", "Q54RY4", "DDB_G0282899", "P20791", "DDB_G0276399", "Q54W37", "DDB_G0280761", "Q54UX4", "DDB_G0280761", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q1ZXE7", "DDB_G0286169", "P20790", "DDB_G0280043", "Q54RY4", "DDB_G0282899", "P20791", "DDB_G0276399", "species_113552", "Q54W37", "DDB_G0280761", "Q54UX4", "DDB_G0280761", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q1ZXE7", "DDB_G0286169", "P20790", "DDB_G0280043", "Q54RY4", "DDB_G0282899", "P20791", "DDB_G0276399" ] }, "reaction_10594460": { "compartment": "compartment_5460", "id": "reaction_10594460", "reactome": "R-DDI-916855", "name": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_916850", "species_113594" ], "products": [ "species_880046", "species_113552" ], "modifiers": [ [ "species_10594457", "catalyst" ] ], "additional_components": [ "Q55FI1", "DDB_G0268104", "CHEBI:33739" ] }, "reaction_10589611": { "compartment": "compartment_70101", "id": "reaction_10589611", "reactome": "R-DDI-374909", "name": "Metabolism of Noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209789", "species_29356", "species_29368" ], "products": [ "species_5279533", "species_29382", "species_29408" ], "modifiers": [ [ "species_10583604", "catalyst" ] ], "additional_components": [ "Q54RP5", "DDB_G0282999", "species_113596" ] }, "reaction_10625621": { "compartment": "compartment_7660", "id": "reaction_10625621", "reactome": "R-DDI-9029434", "name": "p-S363,S380,T573 RS6K translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625593" ], "products": [ "species_10625619" ], "modifiers": [], "additional_components": [ "P34102", "DDB_G0286125", "Q8MYF1", "DDB_G0277449", "Q8MYF1", "DDB_G0277449", "P34102", "DDB_G0286125" ] }, "reaction_10613600": { "compartment": "compartment_876", "id": "reaction_10613600", "reactome": "R-DDI-6797630", "name": "LRPP4(LRPP1-3,5) hydrolyse LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_417891" ], "products": [ "species_109277", "species_6797635" ], "modifiers": [ [ "species_10613597", "catalyst" ] ], "additional_components": [ "Q54PR7", "DDB_G0284367", "Q86AF0", "DDB_G0284367", "Q8MXL9", "DDB_G0284367" ] }, "reaction_10590801": { "compartment": "compartment_70101", "id": "reaction_10590801", "reactome": "R-DDI-418553", "name": "cAMP degradation by Phosphodiesterases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10590798", "catalyst" ] ], "additional_components": [ "B0G0Y8", "DDB_G0268634", "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121" ] }, "reaction_10627473": { "compartment": "compartment_70101", "id": "reaction_10627473", "reactome": "R-DDI-9708261", "name": "PDE4A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10583084", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121" ] }, "reaction_10626265": { "compartment": "compartment_70101", "id": "reaction_10626265", "reactome": "R-DDI-9629675", "name": "PDE3A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10626262", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121" ] }, "reaction_10627406": { "compartment": "compartment_70101", "id": "reaction_10627406", "reactome": "R-DDI-9705507", "name": "PDE3B hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10627403", "catalyst" ] ], "additional_components": [ "Q23917", "DDB_G0284331", "Q86H13", "DDB_G0289121" ] }, "reaction_10590562": { "compartment": "compartment_876", "id": "reaction_10590562", "reactome": "R-DDI-392064", "name": "G alpha (z) inhibits adenylate cyclase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590558", "species_10583022" ], "products": [ "species_10590560" ], "modifiers": [], "additional_components": [ "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "species_29926", "Q03100", "DDB_G0281545" ] }, "reaction_10624233": { "compartment": "compartment_876", "id": "reaction_10624233", "reactome": "R-DDI-8981892", "name": "Active G alpha (z) binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590558", "species_10624229" ], "products": [ "species_10624231" ], "modifiers": [], "additional_components": [ "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "Q55E55", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q54M81", "DDB_G0286817", "Q55E55", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q54M81", "DDB_G0286817", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438" ] }, "reaction_10624313": { "compartment": "compartment_876", "id": "reaction_10624313", "reactome": "R-DDI-8982021", "name": "G alpha (z) in G alpha (z):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624231" ], "products": [ "species_10624301", "species_29372" ], "modifiers": [ [ "species_10624231", "catalyst" ] ], "additional_components": [ "Q55E55", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q54M81", "DDB_G0286817", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "Q55E55", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q54M81", "DDB_G0286817", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29420", "Q55E55", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q54M81", "DDB_G0286817", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438" ] }, "reaction_10624303": { "compartment": "compartment_876", "id": "reaction_10624303", "reactome": "R-DDI-8982018", "name": "G alpha (z):RGS complex dissociates to give inactive G alpha (z)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10624301" ], "products": [ "species_10624229", "species_10594134" ], "modifiers": [], "additional_components": [ "Q55E55", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q54M81", "DDB_G0286817", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29420", "Q55E55", "DDB_G0286817", "Q54LD1", "DDB_G0286817", "Q556I3", "DDB_G0286817", "Q54M81", "DDB_G0286817", "species_29420", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343" ] }, "reaction_10590810": { "compartment": "compartment_876", "id": "reaction_10590810", "reactome": "R-DDI-418574", "name": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10590657" ], "products": [ "species_10590807" ], "modifiers": [ [ "species_10590657", "catalyst" ] ], "additional_components": [ "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29420", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "species_29438" ] }, "reaction_10625832": { "compartment": "compartment_70101", "id": "reaction_10625832", "reactome": "R-DDI-9603279", "name": "PIP3 recruits PDK1 and AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10587607", "species_10590487" ], "products": [ "species_10625830" ], "modifiers": [], "additional_components": [ "DDB_G0281471", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "Q54TW2", "DDB_G0281471", "species_179838", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795" ] }, "reaction_10590605": { "compartment": "compartment_70101", "id": "reaction_10590605", "reactome": "R-DDI-392300", "name": "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10590602", "catalyst" ] ], "additional_components": [ "Q54DK0", "DDB_G0292252", "P54675", "DDB_G0275011", "P54673", "DDB_G0278727", "Q54S78", "DDB_G0282625", "Q55FX5", "DDB_G0282625", "P54674", "DDB_G0283081", "P36408", "DDB_G0277143" ] }, "reaction_10602042": { "compartment": "compartment_70101", "id": "reaction_10602042", "reactome": "R-DDI-3134962", "name": "DHX36 binds DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602038", "species_3134861" ], "products": [ "species_10602040" ], "modifiers": [], "additional_components": [ "DDB_G0275313", "Q869Z1", "DDB_G0275313" ] }, "reaction_10602073": { "compartment": "compartment_70101", "id": "reaction_10602073", "reactome": "R-DDI-3204303", "name": "MRE11 binds cytosolic DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_874088", "species_10602069" ], "products": [ "species_10602071" ], "modifiers": [], "additional_components": [ "DDB_G0293546", "Q54BN2", "DDB_G0293546", "species_874088" ] }, "reaction_10624938": { "compartment": "compartment_70101", "id": "reaction_10624938", "reactome": "R-DDI-9013869", "name": "DDX41 binds bacterial c-di-AMP, c-di-GMP ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8982080", "species_10602033" ], "products": [ "species_10624936" ], "modifiers": [], "additional_components": [ "CHEBI:49537", "CHEBI:47037", "DDB_G0287361", "Q54KG1", "DDB_G0287361", "CHEBI:49537", "CHEBI:47037" ] }, "reaction_10605089": { "compartment": "compartment_263163", "id": "reaction_10605089", "reactome": "R-DDI-5333658", "name": "CLAT:AP1:CLVS bind PI(3,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5334668", "species_10605085" ], "products": [ "species_10605087" ], "modifiers": [], "additional_components": [ "P25870", "DDB_G0277221", "Q54X82", "DDB_G0279141", "Q8I8U2", "DDB_G0281957", "Q54HS9", "DDB_G0289247", "Q54WW3", "DDB_G0279359", "B0G185", "DDB_G0295711", "P25870", "DDB_G0277221", "Q54X82", "DDB_G0279141", "Q8I8U2", "DDB_G0281957", "Q54HS9", "DDB_G0289247", "Q54WW3", "DDB_G0279359", "B0G185", "DDB_G0295711", "species_1806205" ] }, "reaction_10604872": { "compartment": "compartment_171907", "id": "reaction_10604872", "reactome": "R-DDI-5229111", "name": "AP4 transports APP from trans-Golgi network to endosome lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604855" ], "products": [ "species_10604869" ], "modifiers": [ [ "species_10604855", "catalyst" ] ], "additional_components": [ "Q54VE0", "DDB_G0280427", "Q9GPF0", "DDB_G0276945", "Q54NZ4", "DDB_G0284905", "Q54R84", "DDB_G0283319", "Q9GPF0", "DDB_G0276945", "Q54NZ4", "DDB_G0284905", "Q54R84", "DDB_G0283319", "Q54VE0", "DDB_G0280427", "Q54VE0", "DDB_G0280427", "Q9GPF0", "DDB_G0276945", "Q54NZ4", "DDB_G0284905", "Q54R84", "DDB_G0283319" ] }, "reaction_10592299": { "compartment": "compartment_70101", "id": "reaction_10592299", "reactome": "R-DDI-432706", "name": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10591135", "species_10591129", "species_10591141", "species_10592293" ], "products": [ "species_10589294", "species_29372", "species_10592297" ], "modifiers": [], "additional_components": [ "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "O00909", "DDB_G0289173", "Q54Y34", "DDB_G0292332", "Q1ZXA5", "DDB_G0292332", "Q54YV7", "DDB_G0278057", "Q54HK2", "DDB_G0289435", "Q55AR1", "DDB_G0271792", "Q54JJ3", "DDB_G0288015", "Q54SH9", "DDB_G0282457", "Q54V41", "DDB_G0280633", "Q54V47", "DDB_G0280621", "Q54VB0", "DDB_G0280479", "species_29438", "Q54HS9", "DDB_G0289247", "Q54WW3", "DDB_G0279359", "B0G185", "DDB_G0295711", "Q8I8U2", "DDB_G0281957", "Q54X82", "DDB_G0279141", "species_29420", "Q54V41", "DDB_G0280633", "Q54Y34", "DDB_G0292332", "Q54HK2", "DDB_G0289435", "Q54YV7", "DDB_G0278057", "Q54JJ3", "DDB_G0288015", "Q54V47", "DDB_G0280621", "O00909", "DDB_G0289173", "Q54VB0", "DDB_G0280479", "Q55AR1", "DDB_G0271792", "Q1ZXA5", "DDB_G0292332", "Q54SH9", "DDB_G0282457", "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "Q54HS9", "DDB_G0289247", "Q54WW3", "DDB_G0279359", "B0G185", "DDB_G0295711", "Q8I8U2", "DDB_G0281957", "Q54X82", "DDB_G0279141", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131" ] }, "reaction_10592302": { "compartment": "compartment_70101", "id": "reaction_10592302", "reactome": "R-DDI-432707", "name": "trans-Golgi Network Lysosomal Vesicle Scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10592297" ], "products": [ "species_10591135", "species_29372", "species_29420", "species_10591141", "species_10592225" ], "modifiers": [ [ "species_10592297", "catalyst" ] ], "additional_components": [ "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "Q54HS9", "DDB_G0289247", "Q54WW3", "DDB_G0279359", "B0G185", "DDB_G0295711", "Q8I8U2", "DDB_G0281957", "Q54X82", "DDB_G0279141", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "Q54X82", "DDB_G0279141", "Q8I8U2", "DDB_G0281957", "Q54HS9", "DDB_G0289247", "B0G185", "DDB_G0295711", "Q54WW3", "DDB_G0279359", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "Q54HS9", "DDB_G0289247", "Q54WW3", "DDB_G0279359", "B0G185", "DDB_G0295711", "Q8I8U2", "DDB_G0281957", "Q54X82", "DDB_G0279141", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131" ] }, "reaction_10589739": { "compartment": "compartment_70101", "id": "reaction_10589739", "reactome": "R-DDI-376357", "name": "Vamp7 associated Lysosome to Plasma membrane transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589710", "species_10589716", "species_10589728" ], "products": [ "species_10589710", "species_10589734", "species_10589716" ], "modifiers": [ [ "species_10589736", "catalyst" ] ], "additional_components": [ "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556", "Q54NW7", "DDB_G0284951", "Q86AQ7", "DDB_G0277173", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54NW7", "DDB_G0284951", "Q86AQ7", "DDB_G0277173", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556", "Q54NW7", "DDB_G0284951", "Q86AQ7", "DDB_G0277173", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590" ] }, "reaction_10589773": { "compartment": "compartment_876", "id": "reaction_10589773", "reactome": "R-DDI-376369", "name": "Vamp2 associated secretory vesicle to plasma membrane transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589710", "species_10589716", "species_10589762" ], "products": [ "species_10589710", "species_10589768", "species_10589716" ], "modifiers": [ [ "species_10589770", "catalyst" ] ], "additional_components": [ "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590" ] }, "reaction_10589340": { "compartment": "compartment_70101", "id": "reaction_10589340", "reactome": "R-DDI-350769", "name": "trans-Golgi Network Coat Activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589294", "species_29438" ], "products": [ "species_29420", "species_10589320" ], "modifiers": [ [ "species_10589337", "catalyst" ] ], "additional_components": [ "species_29420", "Q54V41", "DDB_G0280633", "Q54Y34", "DDB_G0292332", "Q54HK2", "DDB_G0289435", "Q54YV7", "DDB_G0278057", "Q54JJ3", "DDB_G0288015", "Q54V47", "DDB_G0280621", "O00909", "DDB_G0289173", "Q54VB0", "DDB_G0280479", "Q55AR1", "DDB_G0271792", "Q1ZXA5", "DDB_G0292332", "Q54SH9", "DDB_G0282457", "O00909", "DDB_G0289173", "Q54Y34", "DDB_G0292332", "Q1ZXA5", "DDB_G0292332", "Q54YV7", "DDB_G0278057", "Q54HK2", "DDB_G0289435", "Q55AR1", "DDB_G0271792", "Q54JJ3", "DDB_G0288015", "Q54SH9", "DDB_G0282457", "Q54V41", "DDB_G0280633", "Q54V47", "DDB_G0280621", "Q54VB0", "DDB_G0280479", "species_29438", "Q54X30", "DDB_G0290771", "Q86KG9", "DDB_G0290771", "Q54FL9", "DDB_G0290771" ] }, "reaction_10589756": { "compartment": "compartment_70101", "id": "reaction_10589756", "reactome": "R-DDI-376364", "name": "Vamp8 associated secretory vesicle to plasma membrane transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589710", "species_10589716", "species_10589745" ], "products": [ "species_10589710", "species_10589751", "species_10589716" ], "modifiers": [ [ "species_10589753", "catalyst" ] ], "additional_components": [ "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54HM5", "DDB_G0289379", "Q55DR2", "DDB_G0270556", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590" ] }, "reaction_10586000": { "compartment": "compartment_984", "id": "reaction_10586000", "reactome": "R-DDI-189102", "name": "maltose + H2O => 2 D-glucose (maltase-glucoamylase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_188986" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10585997", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10586372": { "compartment": "compartment_984", "id": "reaction_10586372", "reactome": "R-DDI-191101", "name": "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_191103" ], "products": [ "species_188986", "species_70115" ], "modifiers": [ [ "species_10585987", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10585990": { "compartment": "compartment_984", "id": "reaction_10585990", "reactome": "R-DDI-189053", "name": "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_189108" ], "products": [ "species_191103", "species_188986", "species_70115" ], "modifiers": [ [ "species_10585987", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10586374": { "compartment": "compartment_984", "id": "reaction_10586374", "reactome": "R-DDI-191108", "name": "maltose + H2O => 2 D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_188986" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10585987", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10585993": { "compartment": "compartment_984", "id": "reaction_10585993", "reactome": "R-DDI-189069", "name": "sucrose + H2O => glucose + fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_188980" ], "products": [ "species_189049", "species_70115" ], "modifiers": [ [ "species_10585987", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10586376": { "compartment": "compartment_984", "id": "reaction_10586376", "reactome": "R-DDI-191116", "name": "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_191103" ], "products": [ "species_188986", "species_70115" ], "modifiers": [ [ "species_10585997", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10606570": { "compartment": "compartment_984", "id": "reaction_10606570", "reactome": "R-DDI-5659861", "name": "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_5659875" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10585987", "catalyst" ] ], "additional_components": [ "Q55D50", "DDB_G0269790" ] }, "reaction_10623860": { "compartment": "compartment_7660", "id": "reaction_10623860", "reactome": "R-DDI-8953398", "name": "PIR oxygenates quercetin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8953397", "species_113685" ], "products": [ "species_8953399", "species_8953383" ], "modifiers": [ [ "species_10623857", "catalyst" ] ], "additional_components": [ "DDB_G0273413" ] }, "reaction_10600033": { "compartment": "compartment_876", "id": "reaction_10600033", "reactome": "R-DDI-2029471", "name": "Hydrolysis of PC to PA by PLD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429802", "species_29356" ], "products": [ "species_264618", "species_1602448" ], "modifiers": [ [ "species_10600030", "catalyst" ] ], "additional_components": [ "Q54Z25", "DDB_G0277949" ] }, "reaction_10600008": { "compartment": "compartment_876", "id": "reaction_10600008", "reactome": "R-DDI-2029468", "name": "Conversion of PA into DAG by PAP-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1602448" ], "products": [ "species_29372", "species_112275" ], "modifiers": [ [ "species_10600005", "catalyst" ] ], "additional_components": [ "Q54PR7", "DDB_G0284367", "Q86AF0", "DDB_G0284367", "Q8MXL9", "DDB_G0284367" ] }, "reaction_10620323": { "compartment": "compartment_876", "id": "reaction_10620323", "reactome": "R-DDI-8868648", "name": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10620318" ], "products": [ "species_29372", "species_10620320" ], "modifiers": [ [ "species_10620318", "catalyst" ] ], "additional_components": [ "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "species_179856", "Q54U74", "DDB_G0281235", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q555L8", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q75JD4", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "B0G198", "DDB_G0295683", "Q1ZXE9", "DDB_G0285703", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29438", "Q54U74", "DDB_G0281235", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q54KI4", "DDB_G0287325", "species_1806180", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "species_113592", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q1ZXE9", "DDB_G0285703", "B0G198", "DDB_G0295683", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q55AN3", "DDB_G0274805", "Q555L8", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "C7FZZ0", "DDB_G0274805", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29438", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "species_179856", "Q54U74", "DDB_G0281235", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q555L8", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q75JD4", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "B0G198", "DDB_G0295683", "Q1ZXE9", "DDB_G0285703", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29438" ] }, "reaction_10619620": { "compartment": "compartment_876", "id": "reaction_10619620", "reactome": "R-DDI-8856808", "name": "Recruitment of AP-2 complex and clathrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10591129", "species_10619610", "species_10619527", "species_10619616", "species_10619539" ], "products": [ "species_10619618" ], "modifiers": [], "additional_components": [ "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q54KI4", "DDB_G0287325", "species_179856", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54U74", "DDB_G0281235", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q54U74", "DDB_G0281235", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q54KI4", "DDB_G0287325", "species_179856" ] }, "reaction_10620325": { "compartment": "compartment_876", "id": "reaction_10620325", "reactome": "R-DDI-8868651", "name": "Endophilins recruit synaptojanins to the clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620314", "species_10598818" ], "products": [ "species_10620318" ], "modifiers": [], "additional_components": [ "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "species_179856", "Q54U74", "DDB_G0281235", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q555L8", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q75JD4", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "B0G198", "DDB_G0295683", "Q1ZXE9", "DDB_G0285703", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29438", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "species_179856", "Q54U74", "DDB_G0281235", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q555L8", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q75JD4", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "B0G198", "DDB_G0295683", "Q1ZXE9", "DDB_G0285703", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29438" ] }, "reaction_10620267": { "compartment": "compartment_876", "id": "reaction_10620267", "reactome": "R-DDI-8868066", "name": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10598590", "catalyst" ] ], "additional_components": [ "Q54DL4", "DDB_G0292190", "Q54M96", "DDB_G0292190", "Q54VR4", "DDB_G0292190", "Q556H0", "DDB_G0292190", "Q55GN6", "DDB_G0292190", "Q86A02", "DDB_G0275635", "Q86D86", "DDB_G0283615" ] }, "reaction_10619662": { "compartment": "compartment_876", "id": "reaction_10619662", "reactome": "R-DDI-8862280", "name": "FCHo proteins bind nascent clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619596", "species_10619608", "species_10588585", "species_10619588", "species_10619590", "species_10619586" ], "products": [ "species_10619610" ], "modifiers": [], "additional_components": [ "species_179856", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q555L8", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q75JD4", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "DDB_G0287325", "DDB_G0287325", "DDB_G0287325", "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q54KI4", "DDB_G0287325", "species_179856", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403" ] }, "reaction_10619630": { "compartment": "compartment_876", "id": "reaction_10619630", "reactome": "R-DDI-8856813", "name": "AAK1 phosphorylates AP-2 mu subunit at T156", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10619618" ], "products": [ "species_29370", "species_10619627" ], "modifiers": [ [ "species_10619618", "catalyst" ] ], "additional_components": [ "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q54U74", "DDB_G0281235", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q54KI4", "DDB_G0287325", "species_179856", "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q54U74", "DDB_G0281235", "species_179856", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q54U74", "DDB_G0281235", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q54KI4", "DDB_G0287325", "species_179856" ] }, "reaction_10621967": { "compartment": "compartment_24339", "id": "reaction_10621967", "reactome": "R-DDI-8871194", "name": "RAB5 and GAPVD1 bind AP-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10621961", "species_10620427" ], "products": [ "species_10621963" ], "modifiers": [], "additional_components": [ "Q86JP3", "DDB_G0271984", "species_29420", "Q54HF9", "DDB_G0291115", "Q54W41", "DDB_G0291115", "Q55AA6", "DDB_G0291115", "Q54NU1", "DDB_G0291115", "Q55AI4", "DDB_G0291115", "Q54VS5", "DDB_G0291115", "Q54F48", "DDB_G0291115", "Q54U74", "DDB_G0281235", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q54KI4", "DDB_G0287325", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29420", "Q54UC8", "DDB_G0281155", "Q55FQ9", "DDB_G0267440", "Q54P67", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54JR2", "DDB_G0287691", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54Y50", "DDB_G0278685", "species_1806180", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q8T867", "DDB_G0276447", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "species_113592", "Q1ZXE9", "DDB_G0285703", "B0G198", "DDB_G0295683", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q55AN3", "DDB_G0274805", "Q555L8", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "C7FZZ0", "DDB_G0274805", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q54U74", "DDB_G0281235", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q54KI4", "DDB_G0287325", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29420", "Q54UC8", "DDB_G0281155", "Q55FQ9", "DDB_G0267440", "Q54P67", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54JR2", "DDB_G0287691", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54Y50", "DDB_G0278685", "species_1806180", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q8T867", "DDB_G0276447", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "species_113592", "Q1ZXE9", "DDB_G0285703", "B0G198", "DDB_G0295683", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q55AN3", "DDB_G0274805", "Q555L8", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "C7FZZ0", "DDB_G0274805", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q86JP3", "DDB_G0271984", "Q54HF9", "DDB_G0291115", "Q54W41", "DDB_G0291115", "Q55AA6", "DDB_G0291115", "Q54NU1", "DDB_G0291115", "Q55AI4", "DDB_G0291115", "Q54VS5", "DDB_G0291115", "Q54F48", "DDB_G0291115" ] }, "reaction_10619890": { "compartment": "compartment_70101", "id": "reaction_10619890", "reactome": "R-DDI-8866275", "name": "UBQLNs bind UIM-containing adaptor proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619886", "species_10619878" ], "products": [ "species_10619888" ], "modifiers": [], "additional_components": [ "Q54KI4", "DDB_G0287325", "Q54EH1", "DDB_G0291512", "DDB_G0267452", "Q9NIF3", "DDB_G0267452", "Q54KI4", "DDB_G0287325", "Q54EH1", "DDB_G0291512" ] }, "reaction_10619715": { "compartment": "compartment_70101", "id": "reaction_10619715", "reactome": "R-DDI-8863723", "name": "COP9 and TOR1 deneddylate STON2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619706" ], "products": [ "species_10619710", "species_10619704", "species_10611062", "species_10619684" ], "modifiers": [ [ "species_10619706", "catalyst" ] ], "additional_components": [ "Q55FE2", "DDB_G0268156", "Q75K24", "DDB_G0275471", "Q54C92", "DDB_G0293180", "Q54QX3", "DDB_G0283587", "Q55BD5", "DDB_G0271282", "Q54E53", "DDB_G0291848", "Q54HL6", "DDB_G0289361", "Q54PF3", "DDB_G0284597", "Q54B82", "DDB_G0293844", "P54672", "DDB_G0277139", "DDB_G0277139", "Q75K24", "DDB_G0275471", "Q54C92", "DDB_G0293180", "Q54QX3", "DDB_G0283587", "Q55BD5", "DDB_G0271282", "Q54E53", "DDB_G0291848", "Q54HL6", "DDB_G0289361", "Q54PF3", "DDB_G0284597", "Q54B82", "DDB_G0293844", "DDB_G0278711", "Q55FE2", "DDB_G0268156", "Q55FE2", "DDB_G0268156", "Q75K24", "DDB_G0275471", "Q54C92", "DDB_G0293180", "Q54QX3", "DDB_G0283587", "Q55BD5", "DDB_G0271282", "Q54E53", "DDB_G0291848", "Q54HL6", "DDB_G0289361", "Q54PF3", "DDB_G0284597", "Q54B82", "DDB_G0293844", "P54672", "DDB_G0277139" ] }, "reaction_10627348": { "compartment": "compartment_70101", "id": "reaction_10627348", "reactome": "R-DDI-9681616", "name": "AP2 binds chlorpromazine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9648300", "species_10619527" ], "products": [ "species_10619943" ], "modifiers": [], "additional_components": [ "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439" ] }, "reaction_10619717": { "compartment": "compartment_70101", "id": "reaction_10619717", "reactome": "R-DDI-8863727", "name": "STON2 is neddylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619710", "species_10611062" ], "products": [ "species_10619672" ], "modifiers": [], "additional_components": [ "DDB_G0277139", "DDB_G0278711", "DDB_G0277139" ] }, "reaction_10619945": { "compartment": "compartment_876", "id": "reaction_10619945", "reactome": "R-DDI-8866277", "name": "AP-2 directly binds some endocytic cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619527", "species_10619939" ], "products": [ "species_10619941" ], "modifiers": [ [ "species_10619943", "inhibitor" ] ], "additional_components": [ "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439" ] }, "reaction_10620089": { "compartment": "compartment_876", "id": "reaction_10620089", "reactome": "R-DDI-8867613", "name": "PICALM binds R-SNAREs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620079", "species_10620085" ], "products": [ "species_10620087" ], "modifiers": [], "additional_components": [ "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54Y50", "DDB_G0278685", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061" ] }, "reaction_10619708": { "compartment": "compartment_70101", "id": "reaction_10619708", "reactome": "R-DDI-8863721", "name": "NEDD8-STON binds TOR1 hexamer and COP9 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619704", "species_10619672", "species_10619684" ], "products": [ "species_10619706" ], "modifiers": [], "additional_components": [ "Q75K24", "DDB_G0275471", "Q54C92", "DDB_G0293180", "Q54QX3", "DDB_G0283587", "Q55BD5", "DDB_G0271282", "Q54E53", "DDB_G0291848", "Q54HL6", "DDB_G0289361", "Q54PF3", "DDB_G0284597", "Q54B82", "DDB_G0293844", "DDB_G0277139", "Q55FE2", "DDB_G0268156", "Q55FE2", "DDB_G0268156", "Q75K24", "DDB_G0275471", "Q54C92", "DDB_G0293180", "Q54QX3", "DDB_G0283587", "Q55BD5", "DDB_G0271282", "Q54E53", "DDB_G0291848", "Q54HL6", "DDB_G0289361", "Q54PF3", "DDB_G0284597", "Q54B82", "DDB_G0293844", "P54672", "DDB_G0277139" ] }, "reaction_10620237": { "compartment": "compartment_876", "id": "reaction_10620237", "reactome": "R-DDI-8867756", "name": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620157", "species_10619627" ], "products": [ "species_10620159" ], "modifiers": [], "additional_components": [ "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q54U74", "DDB_G0281235", "species_179856", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q54U74", "DDB_G0281235", "species_179856", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691" ] }, "reaction_10620269": { "compartment": "compartment_876", "id": "reaction_10620269", "reactome": "R-DDI-8868071", "name": "Clathrin recruits PIK3C2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620159", "species_10598852" ], "products": [ "species_10620161" ], "modifiers": [], "additional_components": [ "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q54U74", "DDB_G0281235", "species_179856", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q54S78", "DDB_G0282625", "Q55FX5", "DDB_G0282625", "P54673", "DDB_G0278727", "P54674", "DDB_G0283081", "P54675", "DDB_G0275011", "Q54S78", "DDB_G0282625", "Q55FX5", "DDB_G0282625", "P54673", "DDB_G0278727", "P54674", "DDB_G0283081", "P54675", "DDB_G0275011", "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q54U74", "DDB_G0281235", "species_179856", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691" ] }, "reaction_10621965": { "compartment": "compartment_24339", "id": "reaction_10621965", "reactome": "R-DDI-8871193", "name": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10621963" ], "products": [ "species_10620531", "species_10619539" ], "modifiers": [], "additional_components": [ "Q54U74", "DDB_G0281235", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q54KI4", "DDB_G0287325", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29420", "Q54UC8", "DDB_G0281155", "Q55FQ9", "DDB_G0267440", "Q54P67", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54JR2", "DDB_G0287691", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54Y50", "DDB_G0278685", "species_1806180", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q8T867", "DDB_G0276447", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "species_113592", "Q1ZXE9", "DDB_G0285703", "B0G198", "DDB_G0295683", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q55AN3", "DDB_G0274805", "Q555L8", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "C7FZZ0", "DDB_G0274805", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q86JP3", "DDB_G0271984", "Q54HF9", "DDB_G0291115", "Q54W41", "DDB_G0291115", "Q55AA6", "DDB_G0291115", "Q54NU1", "DDB_G0291115", "Q55AI4", "DDB_G0291115", "Q54VS5", "DDB_G0291115", "Q54F48", "DDB_G0291115", "Q54U74", "DDB_G0281235", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q54KI4", "DDB_G0287325", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29420", "Q54UC8", "DDB_G0281155", "Q55FQ9", "DDB_G0267440", "Q54P67", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54JR2", "DDB_G0287691", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54Y50", "DDB_G0278685", "species_1806180", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q8T867", "DDB_G0276447", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "species_113592", "Q1ZXE9", "DDB_G0285703", "B0G198", "DDB_G0295683", "Q55AN3", "DDB_G0274805", "Q555L8", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "C7FZZ0", "DDB_G0274805", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q86JP3", "DDB_G0271984", "species_29438", "Q54HF9", "DDB_G0291115", "Q54W41", "DDB_G0291115", "Q55AA6", "DDB_G0291115", "Q54NU1", "DDB_G0291115", "Q55AI4", "DDB_G0291115", "Q54VS5", "DDB_G0291115", "Q54F48", "DDB_G0291115", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111" ] }, "reaction_10620272": { "compartment": "compartment_876", "id": "reaction_10620272", "reactome": "R-DDI-8868072", "name": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10620161", "catalyst" ] ], "additional_components": [ "Q54S78", "DDB_G0282625", "Q55FX5", "DDB_G0282625", "P54673", "DDB_G0278727", "P54674", "DDB_G0283081", "P54675", "DDB_G0275011", "Q555L8", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "Q54U74", "DDB_G0281235", "species_179856", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691" ] }, "reaction_10620432": { "compartment": "compartment_24339", "id": "reaction_10620432", "reactome": "R-DDI-8868658", "name": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10620425" ], "products": [ "species_10620429", "species_29372", "species_10620427" ], "modifiers": [ [ "species_10620425", "catalyst" ] ], "additional_components": [ "Q54U74", "DDB_G0281235", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29420", "Q54KI4", "DDB_G0287325", "Q8T867", "DDB_G0276447", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "species_113592", "P36415", "DDB_G0269144", "Q55AN3", "DDB_G0274805", "Q555L8", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "C7FZZ0", "DDB_G0274805", "Q54UC8", "DDB_G0281155", "Q55FQ9", "DDB_G0267440", "Q54P67", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q54D31", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10591129", "species_10619527", "species_179856" ], "products": [ "species_10619596" ], "modifiers": [], "additional_components": [ "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "species_179856", "P54672", "DDB_G0277139", "Q54X82", "DDB_G0279141", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403" ] }, "reaction_10620438": { "compartment": "compartment_24339", "id": "reaction_10620438", "reactome": "R-DDI-8868659", "name": "Clathrin recruits auxilins to the clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"reaction_10620440": { "compartment": "compartment_24339", "id": "reaction_10620440", "reactome": "R-DDI-8868660", "name": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602861", "species_10620436" ], "products": [ "species_10620425" ], "modifiers": [], "additional_components": [ "species_113592", "P36415", "DDB_G0269144", "Q54U74", "DDB_G0281235", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29420", "Q54KI4", "DDB_G0287325", "Q8T867", "DDB_G0276447", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q55AN3", "DDB_G0274805", "Q555L8", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "C7FZZ0", "DDB_G0274805", "Q54UC8", "DDB_G0281155", "Q55FQ9", "DDB_G0267440", "Q54P67", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54JR2", "DDB_G0287691", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54Y50", "DDB_G0278685", "species_1806180", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "species_113592", "Q1ZXE9", "DDB_G0285703", "B0G198", "DDB_G0295683", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54U74", "DDB_G0281235", "Q8I7P3", "DDB_G0267462", "Q54D97", "DDB_G0292392", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29420", "Q54KI4", "DDB_G0287325", "Q8T867", "DDB_G0276447", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "species_113592", "P36415", "DDB_G0269144", "Q55AN3", "DDB_G0274805", "Q555L8", "DDB_G0274805", "Q75JD4", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "C7FZZ0", "DDB_G0274805", "Q54UC8", "DDB_G0281155", "Q55FQ9", "DDB_G0267440", "Q54P67", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54JR2", "DDB_G0287691", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q8ST87", "DDB_G0280977", "Q54U44", "DDB_G0280973", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54Y50", "DDB_G0278685", "species_1806180", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "Q1ZXE9", "DDB_G0285703", "B0G198", "DDB_G0295683", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403" ] }, "reaction_10620316": { "compartment": "compartment_876", "id": "reaction_10620316", "reactome": "R-DDI-8868236", "name": "BAR domain proteins recruit dynamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10620312", "species_10620310" ], "products": [ "species_10620314" ], "modifiers": [], "additional_components": [ "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29438", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "species_179856", "Q54U74", "DDB_G0281235", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q555L8", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q75JD4", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "B0G198", "DDB_G0295683", "Q1ZXE9", "DDB_G0285703", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "Q86HW6", "DDB_G0280111", "Q54VV7", "DDB_G0280111", "species_179856", "Q54U74", "DDB_G0281235", "Q54KI4", "DDB_G0287325", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q555L8", "DDB_G0274805", "Q54GD0", "DDB_G0290233", "Q75JD4", "DDB_G0274805", "Q55AN3", "DDB_G0274805", "C7FZZ0", "DDB_G0274805", "Q54X82", "DDB_G0279141", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54Y50", "DDB_G0278685", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q55FQ9", "DDB_G0267440", "Q54UC8", "DDB_G0281155", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54P13", "DDB_G0284867", "Q54LE6", "DDB_G0286559", "Q54U44", "DDB_G0280973", "Q8ST87", "DDB_G0280977", "Q54JR2", "DDB_G0287691", "Q54DN5", "DDB_G0291984", "Q54F41", "DDB_G0291131", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "B0G198", "DDB_G0295683", "Q1ZXE9", "DDB_G0285703", "O96626", "DDB_G0288319", "O96623", "DDB_G0282813", "O96624", "DDB_G0292804", "P42528", "DDB_G0283755", "species_113592", "O96622", "DDB_G0277825", "O96625", "DDB_G0269102", "O96621", "DDB_G0272106", "Q55EU6", "DDB_G0268744", "Q54PQ2", "DDB_G0287981", "Q54HE9", "DDB_G0289533", "Q553U6", "DDB_G0275023", "Q54HF0", "DDB_G0289507", "P07828", "DDB_G0289489", "Q554S6", "DDB_G0274131", "Q54HF1", "DDB_G0289505", "Q55CU2", "DDB_G0269902", "P07829", "DDB_G0289487", "Q54JL1", "DDB_G0287981", "P07830", "DDB_G0269234", "Q55DS6", "DDB_G0287981", "Q54JV5", "DDB_G0287779", "Q55DY5", "DDB_G0287981", "Q54GX7", "DDB_G0289811", "Q54L54", "DDB_G0286893", "Q54HE7", "DDB_G0289511", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "species_29438" ] }, "reaction_10601617": { "compartment": "compartment_70101", "id": "reaction_10601617", "reactome": "R-DDI-2872497", "name": "SLC17A3-2 transports cytosolic urate to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30034" ], "products": [ "species_429056" ], "modifiers": [ [ "species_10601614", "catalyst" ] ], "additional_components": [ "Q54UX4", "DDB_G0280761", "Q54W37", "DDB_G0280761" ] }, "reaction_10601536": { "compartment": "compartment_70101", "id": "reaction_10601536", "reactome": "R-DDI-2730692", "name": "CLCN4/5/6 exchange Cl- for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_2731008" ], "products": [ "species_74722", "species_352022" ], "modifiers": [ [ "species_10601533", "catalyst" ] ], "additional_components": [ "DDB_G0278639" ] }, "reaction_10627397": { "compartment": "compartment_70101", "id": "reaction_10627397", "reactome": "R-DDI-9701055", "name": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10627394", "catalyst" ], [ "species_10602358", "catalyst" ] ], "additional_components": [ "Q54J43", "DDB_G0288307", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417" ] }, "reaction_10602360": { "compartment": "compartment_70101", "id": "reaction_10602360", "reactome": "R-DDI-3295579", "name": "TRPs transport extracellular Ca2+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10602335", "catalyst" ], [ "species_10602358", "catalyst" ] ], "additional_components": [ "Q54EY0", "DDB_G0291275", "Q54J43", "DDB_G0288307", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417" ] }, "reaction_10601528": { "compartment": "compartment_70101", "id": "reaction_10601528", "reactome": "R-DDI-2684901", "name": "ANOs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10601525", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q54BH1", "DDB_G0293626", "Q55GA1", "DDB_G0293626" ] }, "reaction_10601608": { "compartment": "compartment_70101", "id": "reaction_10601608", "reactome": "R-DDI-2744228", "name": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10601605", "catalyst" ] ], "additional_components": [ "Q54C67", "DDB_G0293130", "Q54LQ4", "DDB_G0286491" ] }, "reaction_10601626": { "compartment": "compartment_70101", "id": "reaction_10601626", "reactome": "R-DDI-2872498", "name": "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_83910" ], "products": [ "species_113551", "species_2892454" ], "modifiers": [ [ "species_10601623", "catalyst" ] ], "additional_components": [ "Q54UX4", "DDB_G0280761", "Q54W37", "DDB_G0280761" ] }, "reaction_10627086": { "compartment": "compartment_70101", "id": "reaction_10627086", "reactome": "R-DDI-9659568", "name": "ANO1 transports cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10601485", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q54BH1", "DDB_G0293626", "Q55GA1", "DDB_G0293626" ] }, "reaction_10592547": { "compartment": "compartment_876", "id": "reaction_10592547", "reactome": "R-DDI-444416", "name": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31633" ], "products": [ "species_140912" ], "modifiers": [ [ "species_10592544", "catalyst" ] ], "additional_components": [ "Q8I0L6", "DDB_G0280059", "Q9NIV0", "DDB_G0283389" ] }, "reaction_10592822": { "compartment": "compartment_876", "id": "reaction_10592822", "reactome": "R-DDI-446277", "name": "RhCG mediates ammonium efflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10592535", "catalyst" ] ], "additional_components": [ "Q8I0L6", "DDB_G0280059", "Q9NIV0", "DDB_G0283389" ] }, "reaction_10592552": { "compartment": "compartment_876", "id": "reaction_10592552", "reactome": "R-DDI-444419", "name": "RhBG mediates ammonium effflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10592549", "catalyst" ] ], "additional_components": [ "DDB_G0280059" ] }, "reaction_10592824": { "compartment": "compartment_876", "id": "reaction_10592824", "reactome": "R-DDI-446278", "name": "RhBG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10592549", "catalyst" ] ], "additional_components": [ "DDB_G0280059" ] }, "reaction_10592538": { "compartment": "compartment_876", "id": "reaction_10592538", "reactome": "R-DDI-444393", "name": "RhCG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10592535", "catalyst" ] ], "additional_components": [ "Q8I0L6", "DDB_G0280059", "Q9NIV0", "DDB_G0283389" ] }, "reaction_10592523": { "compartment": "compartment_876", "id": "reaction_10592523", "reactome": "R-DDI-444126", "name": "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_432019" ], "products": [ "species_29514" ], "modifiers": [ [ "species_10592520", "catalyst" ] ], "additional_components": [ "Q86AP4", "DDB_G0277263" ] }, "reaction_10591788": { "compartment": "compartment_876", "id": "reaction_10591788", "reactome": "R-DDI-429101", "name": "HMIT co-transports myo-inositol with a proton", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_429130" ], "products": [ "species_70106", "species_426910" ], "modifiers": [ [ "species_10591785", "catalyst" ] ], "additional_components": [ "DDB_G0278261" ] }, "reaction_10592375": { "compartment": "compartment_172574", "id": "reaction_10592375", "reactome": "R-DDI-435171", "name": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_445829" ], "products": [ "species_445832", "species_1470067" ], "modifiers": [ [ "species_10592372", "catalyst" ] ], "additional_components": [ "species_29426", "species_71067", "species_266099", "species_29426", "species_266099", "species_71067", "DDB_G0276973" ] }, "reaction_10592422": { "compartment": "compartment_876", "id": "reaction_10592422", "reactome": "R-DDI-437300", "name": "SLC31A1 transports Cu2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_437295" ], "products": [ "species_209799" ], "modifiers": [ [ "species_10592419", "catalyst" ] ], "additional_components": [ "DDB_G0285545" ] }, "reaction_10624126": { "compartment": "compartment_70101", "id": "reaction_10624126", "reactome": "R-DDI-8959798", "name": "SLC30A10 transports Mn2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29418" ], "products": [ "species_266099" ], "modifiers": [ [ "species_10624123", "catalyst" ] ], "additional_components": [ "DDB_G0282067" ] }, "reaction_10592380": { "compartment": "compartment_876", "id": "reaction_10592380", "reactome": "R-DDI-435349", "name": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_435347" ], "products": [ "species_70106", "species_71067" ], "modifiers": [ [ "species_10592377", "catalyst" ] ], "additional_components": [ "DDB_G0276973" ] }, "reaction_10592367": { "compartment": "compartment_876", "id": "reaction_10592367", "reactome": "R-DDI-434650", "name": "MATEs mediate extrusion of xenobiotics", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_446589" ], "products": [ "species_70106", "species_446597" ], "modifiers": [ [ "species_10592364", "catalyst" ] ], "additional_components": [ "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:641", "CHEBI:6801", "CHEBI:16737", "CHEBI:8428", "CHEBI:42820", "CHEBI:16737", "CHEBI:641", "CHEBI:46020", "CHEBI:6801", "Q54YM8", "DDB_G0292132", "Q54DM2", "DDB_G0292132" ] }, "reaction_10594911": { "compartment": "compartment_70101", "id": "reaction_10594911", "reactome": "R-DDI-927789", "name": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594907", "species_10594881" ], "products": [ "species_10594909" ], "modifiers": [], "additional_components": [ "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q9BMX0", "DDB_G0288613", "Q54KR9", "DDB_G0287197", "Q55D17", "DDB_G0269814", "Q54BM2", "DDB_G0293558", "Q553R3", "DDB_G0275395", "Q7YZN9", "DDB_G0277919", "species_29420", "DDB_G0288923", "Q54I89", "DDB_G0288923", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q9BMX0", "DDB_G0288613", "Q54KR9", "DDB_G0287197", "Q55D17", "DDB_G0269814", "Q54BM2", "DDB_G0293558", "Q553R3", "DDB_G0275395", "Q7YZN9", "DDB_G0277919", "species_29420" ] }, "reaction_10594987": { "compartment": "compartment_70101", "id": "reaction_10594987", "reactome": "R-DDI-927889", "name": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10594982" ], "products": [ "species_29370", "species_10594984" ], "modifiers": [ [ "species_10594982", "catalyst" ] ], "additional_components": [ "Q54I89", "DDB_G0288923", "Q54R12", "DDB_G0283447", "Q75JP6", "DDB_G0272470", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q9BMX0", "DDB_G0288613", "Q54DH9", "DDB_G0292240", "Q54ME8", "DDB_G0286007", "Q55E21", "DDB_G0270866", "Q55D61", "DDB_G0269192", "Q54TQ1", "DDB_G0281623", "Q55A46", "DDB_G0272108", "Q7YZN9", "DDB_G0277919", "species_29420", "Q54KR9", "DDB_G0287197", "Q55D17", "DDB_G0269814", "Q54BM2", "DDB_G0293558", "Q553R3", "DDB_G0275395", "Q54I89", "DDB_G0288923", "Q54R12", "DDB_G0283447", "Q75JP6", "DDB_G0272470", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q9BMX0", "DDB_G0288613", "Q54DH9", "DDB_G0292240", "Q54ME8", "DDB_G0286007", "Q55E21", "DDB_G0270866", "Q55D61", "DDB_G0269192", "Q54TQ1", "DDB_G0281623", "Q55A46", "DDB_G0272108", "Q7YZN9", "DDB_G0277919", "species_29420", "Q54KR9", "DDB_G0287197", "Q55D17", "DDB_G0269814", "Q54BM2", "DDB_G0293558", "Q553R3", "DDB_G0275395", "Q54I89", "DDB_G0288923", "Q54R12", "DDB_G0283447", "Q75JP6", "DDB_G0272470", "Q54Y41", "DDB_G0278429", "Q54MA6", "DDB_G0286075", "Q54BN4", "DDB_G0293700", "Q54UU3", "DDB_G0280823", "O77082", "DDB_G0286117", "Q54S90", "DDB_G0282601", "Q55A19", "DDB_G0272250", "Q54I41", "DDB_G0289025", "Q75K27", "DDB_G0275473", "Q54E24", "DDB_G0291864", "Q54PX9", "DDB_G0284237", "Q54PH8", "DDB_G0284533", "Q03409", "DDB_G0271148", "P14132", "DDB_G0289877", "Q54TL8", "DDB_G0281677", "Q55BY1", "DDB_G0270316", "Q54EG3", "DDB_G0291526", "Q54N17", "DDB_G0285561", "Q8T1V4", "DDB_G0277635", "Q54Q51", "DDB_G0284093", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P51405", "DDB_G0272825", "P42520", "DDB_G0290141", "Q54MZ5", "DDB_G0285597", "Q869U7", "DDB_G0276415", "Q76P36", "DDB_G0272308", "Q54X51", "DDB_G0279207", "P90526", "DDB_G0293000", "P46793", "DDB_G0276457", "P27685", "DDB_G0293742", "Q54ZW5", "DDB_G0277345", "Q54G86", "DDB_G0290315", "Q54XI5", "DDB_G0278959", "Q54X53", "DDB_G0279387", "P13023", "DDB_G0274113", "P14329", "DDB_G0281565", "Q54ZD1", "DDB_G0277629", "Q54MK8", "DDB_G0285881", "P11874", "DDB_G0276441", "Q54VZ4", "DDB_G0279997", "Q54D63", "DDB_G0292460", "Q54NG2", "DDB_G0285277", "P34113", "DDB_G0291862", "Q54TW3", "DDB_G0281469", "Q54QM8", "DDB_G0283741", "Q9GS21", "DDB_G0282379", "Q54GK6", "DDB_G0290091", "P48160", "DDB_G0292388", "Q55BE6", "DDB_G0271298", "Q54VN6", "DDB_G0280229", "Q54BQ3", "DDB_G0293502", "Q54J69", "DDB_G0288273", "P22683", "DDB_G0283393", "Q55AQ9", "DDB_G0271668", "Q55BN7", "DDB_G0270424", "P22684", "DDB_G0277907", "P22685", "DDB_G0286501", "Q54J23", "DDB_G0288349", "Q55AB5", "DDB_G0271976", "C7G051", "DDB_G0302511", "Q55CW5", "DDB_G0270984", "Q54XB5", "DDB_G0279061", "Q55BS9", "DDB_G0270380", "Q54XX3", "DDB_G0278539", "Q86K01", "DDB_G0272893", "Q54Z09", "DDB_G0277975", "Q553M7", "DDB_G0275881", "Q54E20", "DDB_G0291870", "Q54Z69", "DDB_G0277803", "Q54J50", "DDB_G0288295", "P16168", "DDB_G0279189", "Q55GJ7", "DDB_G0268302", "Q54MG6", "DDB_G0285971", "Q86L05", "DDB_G0276871", "Q9BMX0", "DDB_G0288613", "Q54DH9", "DDB_G0292240", "Q54ME8", "DDB_G0286007", "Q55E21", "DDB_G0270866", "Q55D61", "DDB_G0269192", "Q54TQ1", "DDB_G0281623", "Q55A46", "DDB_G0272108", "Q7YZN9", "DDB_G0277919", "species_29420", "Q54KR9", "DDB_G0287197", "Q55D17", "DDB_G0269814", "Q54BM2", "DDB_G0293558", "Q553R3", "DDB_G0275395" ] }, "reaction_10582497": { "compartment": "compartment_7660", "id": "reaction_10582497", "reactome": "R-DDI-83790", "name": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582491", "species_10581800" ], "products": [ "species_10582495" ], "modifiers": [], "additional_components": [ "Q8T1F9", "DDB_G0275127", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54YB5", "DDB_G0278321", "Q54FU1", "DDB_G0290591", "Q54U85", "DDB_G0281215", "Q54R53", "DDB_G0283405", "P26355", "DDB_G0275617", "Q54U85", "DDB_G0281215", "Q54R53", "DDB_G0283405", "P26355", "DDB_G0275617", "Q8T1F9", "DDB_G0275127", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54YB5", "DDB_G0278321", "Q54FU1", "DDB_G0290591" ] }, "reaction_10582501": { "compartment": "compartment_7660", "id": "reaction_10582501", "reactome": "R-DDI-83805", "name": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582495", "species_10581897" ], "products": [ "species_10582499" ], "modifiers": [], "additional_components": [ "Q54U85", "DDB_G0281215", "Q54R53", "DDB_G0283405", "P26355", "DDB_G0275617", "Q8T1F9", "DDB_G0275127", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54YB5", "DDB_G0278321", "Q54FU1", "DDB_G0290591", "Q557J3", "DDB_G0273425", "Q54LP2", "DDB_G0286521", "Q54R66", "DDB_G0283365", "Q54IM0", "DDB_G0288665", "Q55FJ5", "DDB_G0268080", "Q86JM3", "DDB_G0272022", "Q54EH2", "DDB_G0291636", "Q54K02", "DDB_G0287707", "Q54SN4", "DDB_G0282339", "Q54FA8", "DDB_G0291037", "Q8T1V7", "DDB_G0277671", "Q86JI9", "DDB_G0271514", "Q55AB6", "DDB_G0272036", "Q86AQ5", "DDB_G0277199", "Q54IZ9", "DDB_G0288449", "Q54YW8", "DDB_G0278039", "Q557J3", "DDB_G0273425", "Q54LP2", "DDB_G0286521", "Q54R66", "DDB_G0283365", "Q54IM0", "DDB_G0288665", "Q55FJ5", "DDB_G0268080", "Q86JM3", "DDB_G0272022", "Q54EH2", "DDB_G0291636", "Q54K02", "DDB_G0287707", "Q54SN4", "DDB_G0282339", "Q54FA8", "DDB_G0291037", "Q8T1V7", "DDB_G0277671", "Q86JI9", "DDB_G0271514", "Q55AB6", "DDB_G0272036", "Q86AQ5", "DDB_G0277199", "Q54IZ9", "DDB_G0288449", "Q54YW8", "DDB_G0278039", "Q54U85", "DDB_G0281215", "Q54R53", "DDB_G0283405", "P26355", "DDB_G0275617", "Q8T1F9", "DDB_G0275127", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54YB5", "DDB_G0278321", "Q54FU1", "DDB_G0290591" ] }, "reaction_10582493": { "compartment": "compartment_7660", "id": "reaction_10582493", "reactome": "R-DDI-83788", "name": "Binding of TFIIIC to Type 2 promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581829", "species_83747" ], "products": [ "species_10582491" ], "modifiers": [], "additional_components": [ "Q8T1F9", "DDB_G0275127", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54YB5", "DDB_G0278321", "Q54FU1", "DDB_G0290591", "Q8T1F9", "DDB_G0275127", "Q54GS8", "DDB_G0289935", "Q54WL4", "DDB_G0279565", "Q54YB5", "DDB_G0278321", "Q54FU1", "DDB_G0290591" ] }, "reaction_10588590": { "compartment": "compartment_70101", "id": "reaction_10588590", "reactome": "R-DDI-205039", "name": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10588141" ], "products": [ "species_10588143", "species_29420" ], "modifiers": [ [ "species_10588587", "catalyst" ] ], "additional_components": [ "species_29420", "P34144", "DDB_G0277869", "P34144", "DDB_G0277869", "species_29438", "Q54F88", "DDB_G0293396", "Q86HN1", "DDB_G0293396", "Q54G10", "DDB_G0293396", "Q86K95", "DDB_G0293396", "Q54GP2", "DDB_G0293396", "Q54J14", "DDB_G0288377", "Q54NG0", "DDB_G0293396", "Q54P24", "DDB_G0284845", "Q54P81", "DDB_G0293396", "Q54S15", "DDB_G0293396", "Q54SR5", "DDB_G0293396", "Q54VX2", "DDB_G0293396", "Q54XA7", "DDB_G0293396", "Q54XW8", "DDB_G0278703", "Q54BV5", "DDB_G0293396", "Q54YP1", "DDB_G0293396", "Q54BY9", "DDB_G0293396", "Q54YZ6", "DDB_G0277987", "Q54C56", "DDB_G0293396", "Q55DL8", "DDB_G0293396", "Q54DW7", "DDB_G0293396", "Q55G61", "DDB_G0268354", "Q54KI4", "DDB_G0287325", "Q8SSQ0", "DDB_G0274605", "Q54C94", "DDB_G0293006", "Q8IS11", "DDB_G0290267", "Q54FF3", "DDB_G0290901", "Q8SSW7", "DDB_G0271868", "Q8IS14", "DDB_G0277913", "Q8ST25", "DDB_G0272032", "Q54H95", "DDB_G0289613", "Q8IS15", "DDB_G0277915", "Q54PQ4", "DDB_G0284329", "Q8IS16", "DDB_G0276963", "Q54XL4", "DDB_G0289613", "Q8IS20", "DDB_G0282381", "Q55FD8", "DDB_G0268578", "B0M0P8", "DDB_G0276371", "Q8IS21", "DDB_G0269222", "Q55GH9", "DDB_G0267666", "Q54SG9", "DDB_G0282475", "Q550V3", "DDB_G0277017", "Q54MM3", "DDB_G0291085", "Q54B37", "DDB_G0293978", "Q54F64", "DDB_G0291085", "Q54PK2", "DDB_G0291085", "Q1ZXN6", "DDB_G0272372", "Q54J11", "DDB_G0288383", "Q54L90", "DDB_G0286773", "Q54WL2", "DDB_G0279569", "Q552M5", "DDB_G0276019", "Q86G47", "DDB_G0289665", "Q8IS18", "DDB_G0269252", "Q8IS19", "DDB_G0289667", "Q8SSQ3", "DDB_G0274607" ] }, "reaction_10626822": { "compartment": "compartment_70101", "id": "reaction_10626822", "reactome": "R-DDI-9647978", "name": "pro-RAS proteins are farnesylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626748", "species_2530486" ], "products": [ "species_111294", "species_10626810" ], "modifiers": [ [ "species_10626817", "catalyst" ], [ "species_10626820", "inhibitor" ] ], "additional_components": [ "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "Q54QY0", "DDB_G0283547", "Q55CB0", "DDB_G0270138", "Q55CA9", "DDB_G0270140", "Q55CB8", "DDB_G0270124", "Q55CB7", "DDB_G0270126", "Q55CC0", "DDB_G0270122", "Q55CB9", "DDB_G0270736", "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "P32252", "DDB_G0292998", "P15064", "DDB_G0293434", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "Q54QY0", "DDB_G0283547", "Q55CB0", "DDB_G0270138", "Q55CA9", "DDB_G0270140", "Q55CB8", "DDB_G0270124", "Q55CB7", "DDB_G0270126", "Q55CC0", "DDB_G0270122", "Q55CB9", "DDB_G0270736", "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "Q54RT9", "DDB_G0283053", "Q55D51", "DDB_G0270948", "Q54RT9", "DDB_G0283053", "Q55D51", "DDB_G0270948" ] }, "reaction_10626891": { "compartment": "compartment_876", "id": "reaction_10626891", "reactome": "R-DDI-9647980", "name": "mature RAS proteins translocate to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626887" ], "products": [ "species_10626889" ], "modifiers": [], "additional_components": [ "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "P32252", "DDB_G0292998", "P15064", "DDB_G0293434", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "Q54QY0", "DDB_G0283547", "Q55CB0", "DDB_G0270138", "Q55CA9", "DDB_G0270140", "Q55CB8", "DDB_G0270124", "Q55CB7", "DDB_G0270126", "Q55CC0", "DDB_G0270122", "Q55CB9", "DDB_G0270736", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140" ] }, "reaction_10626920": { "compartment": "compartment_876", "id": "reaction_10626920", "reactome": "R-DDI-9647991", "name": "Palmostatin B binds RAS depalmitoylases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9647934", "species_10626916" ], "products": [ "species_10626918" ], "modifiers": [], "additional_components": [ "Q54F01", "DDB_G0291205", "Q54T49", "DDB_G0282005", "Q54F01", "DDB_G0291205", "Q54T49", "DDB_G0282005" ] }, "reaction_10626990": { "compartment": "compartment_70101", "id": "reaction_10626990", "reactome": "R-DDI-9653503", "name": "KRAS4B is phosphorylated on serine 181", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10585140" ], "products": [ "species_29370", "species_10626983" ], "modifiers": [ [ "species_10626987", "catalyst" ] ], "additional_components": [ "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "Q55CC0", "DDB_G0270122", "P15064", "DDB_G0293434", "P32253", "DDB_G0281385", "P32252", "DDB_G0292998", "Q75J93", "DDB_G0277381", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q55CA9", "DDB_G0270140", "Q54VD5", "DDB_G0280437", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "P03967", "DDB_G0292996", "Q55CB9", "DDB_G0270736", "Q55CB8", "DDB_G0270124", "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029", "species_30991" ] }, "reaction_10626925": { "compartment": "compartment_876", "id": "reaction_10626925", "reactome": "R-DDI-9647994", "name": "RAS proteins are depalmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10626889" ], "products": [ "species_10626922", "species_8848337" ], "modifiers": [ [ "species_10626916", "catalyst" ], [ "species_10626918", "inhibitor" ] ], "additional_components": [ "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "Q54F01", "DDB_G0291205", "Q54T49", "DDB_G0282005", "Q54F01", "DDB_G0291205", "Q54T49", "DDB_G0282005" ] }, "reaction_10626930": { "compartment": "compartment_876", "id": "reaction_10626930", "reactome": "R-DDI-9649733", "name": "mature p21 RAS binds GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29420", "species_10585142" ], "products": [ "species_10585874" ], "modifiers": [], "additional_components": [ "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29420" ] }, "reaction_10626994": { "compartment": "compartment_876", "id": "reaction_10626994", "reactome": "R-DDI-9653585", "name": "S-Farn-Me KRAS4B binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585140", "species_10583042" ], "products": [ "species_10626992" ], "modifiers": [ [ "species_10626983", "inhibitor" ] ], "additional_components": [ "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "Q55CC0", "DDB_G0270122", "P15064", "DDB_G0293434", "P32253", "DDB_G0281385", "P32252", "DDB_G0292998", "Q75J93", "DDB_G0277381", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q55CA9", "DDB_G0270140", "Q54VD5", "DDB_G0280437", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "P03967", "DDB_G0292996", "Q55CB9", "DDB_G0270736", "Q55CB8", "DDB_G0270124" ] }, "reaction_10627027": { "compartment": "compartment_17906", "id": "reaction_10627027", "reactome": "R-DDI-9653592", "name": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626983" ], "products": [ "species_10627025" ], "modifiers": [], "additional_components": [ "Q55CC0", "DDB_G0270122", "P15064", "DDB_G0293434", "P32253", "DDB_G0281385", "P32252", "DDB_G0292998", "Q75J93", "DDB_G0277381", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q55CA9", "DDB_G0270140", "Q54VD5", "DDB_G0280437", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "P03967", "DDB_G0292996", "Q55CB9", "DDB_G0270736", "Q55CB8", "DDB_G0270124", "Q55CA9", "DDB_G0270140", "Q54VD5", "DDB_G0280437", "Q55CB7", "DDB_G0270126", "Q55CB0", "DDB_G0270138", "Q55CB9", "DDB_G0270736", "Q55CB8", "DDB_G0270124", "Q75J93", "DDB_G0277381", "Q55CC0", "DDB_G0270122", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P32253", "DDB_G0281385", "P32252", "DDB_G0292998", "Q54QY0", "DDB_G0283547", "P32254", "DDB_G0283537" ] }, "reaction_10626928": { "compartment": "compartment_12045", "id": "reaction_10626928", "reactome": "R-DDI-9649732", "name": "Mature S-Farn-Me KRAS4B translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626679" ], "products": [ "species_10585140" ], "modifiers": [], "additional_components": [ "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "Q54QY0", "DDB_G0283547", "Q55CB0", "DDB_G0270138", "Q55CA9", "DDB_G0270140", "Q55CB8", "DDB_G0270124", "Q55CB7", "DDB_G0270126", "Q55CC0", "DDB_G0270122", "Q55CB9", "DDB_G0270736", "Q75J93", "DDB_G0277381", "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "P03967", "DDB_G0292996", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385" ] }, "reaction_10626903": { "compartment": "compartment_20699", "id": "reaction_10626903", "reactome": "R-DDI-9647982", "name": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626681", "species_200993" ], "products": [ "species_10626887", "species_76194" ], "modifiers": [ [ "species_10626900", "catalyst" ] ], "additional_components": [ "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "Q54QY0", "DDB_G0283547", "Q55CB0", "DDB_G0270138", "Q55CA9", "DDB_G0270140", "Q55CB8", "DDB_G0270124", "Q55CB7", "DDB_G0270126", "Q55CC0", "DDB_G0270122", "Q55CB9", "DDB_G0270736", "Q75J93", "DDB_G0277381", "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "P03967", "DDB_G0292996", "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "P32252", "DDB_G0292998", "P15064", "DDB_G0293434", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "Q54QY0", "DDB_G0283547", "Q55CB0", "DDB_G0270138", "Q55CA9", "DDB_G0270140", "Q55CB8", "DDB_G0270124", "Q55CB7", "DDB_G0270126", "Q55CC0", "DDB_G0270122", "Q55CB9", "DDB_G0270736", "Q54RL6", "DDB_G0283039", "Q550I3", "DDB_G0277093" ] }, "reaction_10627061": { "compartment": "compartment_876", "id": "reaction_10627061", "reactome": "R-DDI-9654521", "name": "Calmodulin dissociates KRAS4B from the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626992" ], "products": [ "species_10627059" ], "modifiers": [], "additional_components": [ "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "species_74112", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "Q55CA9", "DDB_G0270140", "Q54VD5", "DDB_G0280437", "Q55CB7", "DDB_G0270126", "Q55CB0", "DDB_G0270138", "Q55CB9", "DDB_G0270736", "Q55CB8", "DDB_G0270124", "Q75J93", "DDB_G0277381", "Q55CC0", "DDB_G0270122", "P15064", "DDB_G0293434", "P03967", "DDB_G0292996", "P32253", "DDB_G0281385", "P32252", "DDB_G0292998", "Q54QY0", "DDB_G0283547", "P32254", "DDB_G0283537" ] }, "reaction_10626905": { "compartment": "compartment_70101", "id": "reaction_10626905", "reactome": "R-DDI-9647987", "name": "FNTB inhibitors bind FNTA:FNTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9653479", "species_10626817" ], "products": [ "species_10626820" ], "modifiers": [], "additional_components": [ "Q54RT9", "DDB_G0283053", "Q55D51", "DDB_G0270948", "Q54RT9", "DDB_G0283053", "Q55D51", "DDB_G0270948" ] }, "reaction_10626685": { "compartment": "compartment_12045", "id": "reaction_10626685", "reactome": "R-DDI-9647977", "name": "ICMT methylates S-Farn RAS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626649", "species_71284" ], "products": [ "species_10626681", "species_71285" ], "modifiers": [ [ "species_10612819", "catalyst" ], [ "species_10626683", "inhibitor" ] ], "additional_components": [ "P15064", "DDB_G0293434", "Q55CA9", "DDB_G0270140", "Q54VD5", "DDB_G0280437", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "P03967", "DDB_G0292996", "Q55CB9", "DDB_G0270736", "Q55CB8", "DDB_G0270124", "Q55CC0", "DDB_G0270122", "P32253", "DDB_G0281385", "P32252", "DDB_G0292998", "Q75J93", "DDB_G0277381", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "P32254", "DDB_G0283537", "P32253", "DDB_G0281385", "Q54VD5", "DDB_G0280437", "Q54QY0", "DDB_G0283547", "Q55CB0", "DDB_G0270138", "Q55CA9", "DDB_G0270140", "Q55CB8", "DDB_G0270124", "Q55CB7", "DDB_G0270126", "Q55CC0", "DDB_G0270122", "Q55CB9", "DDB_G0270736", "Q75J93", "DDB_G0277381", "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "P03967", "DDB_G0292996", "Q558K8", "DDB_G0272799", "species_29426", "Q558K8", "DDB_G0272799", "species_29426" ] }, "reaction_10607347": { "compartment": "compartment_876", "id": "reaction_10607347", "reactome": "R-DDI-5675417", "name": "PEBP1 binds activated RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607343", "species_10607338" ], "products": [ "species_10607345" ], "modifiers": [], "additional_components": [ "DDB_G0283803", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54QK0", "DDB_G0283803" ] }, "reaction_10607267": { "compartment": "compartment_876", "id": "reaction_10607267", "reactome": "R-DDI-5674018", "name": "BRAP binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607263", "species_10585144" ], "products": [ "species_10607265" ], "modifiers": [], "additional_components": [ "DDB_G0270200", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q55C68", "DDB_G0270200" ] }, "reaction_10607319": { "compartment": "compartment_20699", "id": "reaction_10607319", "reactome": "R-DDI-5674140", "name": "PAQR3 binds inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606974", "species_10607315" ], "products": [ "species_10607317" ], "modifiers": [], "additional_components": [ "DDB_G0281557", "Q54FT1", "DDB_G0293838", "Q54B86", "DDB_G0293838", "Q54CB4", "DDB_G0293838", "Q54FT1", "DDB_G0293838", "Q54B86", "DDB_G0293838", "Q54CB4", "DDB_G0293838", "Q54TM7", "DDB_G0281557" ] }, "reaction_10607367": { "compartment": "compartment_876", "id": "reaction_10607367", "reactome": "R-DDI-5675433", "name": "PP5 dephosphorylates RAF1 S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10607338" ], "products": [ "species_29372", "species_10607351" ], "modifiers": [ [ "species_10607364", "catalyst" ] ], "additional_components": [ "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "DDB_G0283157" ] }, "reaction_10607271": { "compartment": "compartment_70101", "id": "reaction_10607271", "reactome": "R-DDI-5674019", "name": "BRAP binds KSR1:MARK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606927", "species_10607263" ], "products": [ "species_10607269" ], "modifiers": [], "additional_components": [ "Q1ZXD6", "DDB_G0294533", "Q54WS5", "DDB_G0279417", "Q23915", "DDB_G0283391", "Q869X3", "DDB_G0282895", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54VC0", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "DDB_G0270200", "Q55C68", "DDB_G0270200", "Q1ZXD6", "DDB_G0294533", "Q54WS5", "DDB_G0279417", "Q23915", "DDB_G0283391", "Q869X3", "DDB_G0282895", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54VC0", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304" ] }, "reaction_10607279": { "compartment": "compartment_876", "id": "reaction_10607279", "reactome": "R-DDI-5674022", "name": "BRAP autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10607265" ], "products": [ "species_10607276" ], "modifiers": [ [ "species_10607265", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q55C68", "DDB_G0270200", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q55C68", "DDB_G0270200", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q55C68", "DDB_G0270200" ] }, "reaction_10607358": { "compartment": "compartment_876", "id": "reaction_10607358", "reactome": "R-DDI-5675431", "name": "PP2A dephosphorylates RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10607351" ], "products": [ "species_29372", "species_10607355" ], "modifiers": [ [ "species_10590274", "catalyst" ], [ "species_10607330", "catalyst" ] ], "additional_components": [ "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "DDB_G0281557" ] }, "reaction_10626932": { "compartment": "compartment_876", "id": "reaction_10626932", "reactome": "R-DDI-9649735", "name": "Intrinsic nucleotide exchange on RAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10585874" ], "products": [ "species_29420", "species_10585144" ], "modifiers": [], "additional_components": [ "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29420", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438" ] }, "reaction_10627146": { "compartment": "compartment_876", "id": "reaction_10627146", "reactome": "R-DDI-9660557", "name": "RAS:GTP binds RAL GDS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627140", "species_10627142" ], "products": [ "species_10627144" ], "modifiers": [], "additional_components": [ "Q8SSQ3", "DDB_G0274607", "Q54WL2", "DDB_G0279569", "Q54L90", "DDB_G0286773", "Q86G47", "DDB_G0289665", "Q552M5", "DDB_G0276019", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252", "P15064", "DDB_G0293434", "species_29438", "P15064", "DDB_G0293434", "species_29438", "Q8SSQ3", "DDB_G0274607", "Q54WL2", "DDB_G0279569", "Q54L90", "DDB_G0286773", "Q86G47", "DDB_G0289665", "Q552M5", "DDB_G0276019", "Q8IS19", "DDB_G0289667", "Q8IS18", "DDB_G0269252" ] }, "reaction_10626937": { "compartment": "compartment_876", "id": "reaction_10626937", "reactome": "R-DDI-9649736", "name": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585144" ], "products": [ "species_10585874" ], "modifiers": [ [ "species_10585144", "catalyst" ] ], "additional_components": [ "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29420", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438" ] }, "reaction_10607066": { "compartment": "compartment_876", "id": "reaction_10607066", "reactome": "R-DDI-5672965", "name": "RAS GEFs promote RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10585874" ], "products": [ "species_29420", "species_10585144" ], "modifiers": [ [ "species_10607063", "catalyst" ] ], "additional_components": [ "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29420", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q8IS14", "DDB_G0277913", "Q8IS15", "DDB_G0277915", "Q8IS16", "DDB_G0276963", "Q8IS20", "DDB_G0282381", "Q8IS21", "DDB_G0269222", "Q8SSQ0", "DDB_G0274605", "Q8SSW7", "DDB_G0271868", "B0M0P8", "DDB_G0276371", "Q8ST25", "DDB_G0272032", "Q54C94", "DDB_G0293006", "Q54FF3", "DDB_G0290901", "Q54H95", "DDB_G0289613", "Q54PQ4", "DDB_G0284329", "Q54XL4", "DDB_G0289613", "Q55FD8", "DDB_G0268578", "Q55GH9", "DDB_G0267666", "Q8IS11", "DDB_G0290267", "species_6797635", "Q54TK8", "DDB_G0281573", "Q8IS12", "DDB_G0275703", "Q54L90", "DDB_G0286773", "Q54WL2", "DDB_G0279569", "Q552M5", "DDB_G0276019", "Q86G47", "DDB_G0289665", "Q8IS18", "DDB_G0269252", "Q8IS19", "DDB_G0289667", "Q8SSQ3", "DDB_G0274607" ] }, "reaction_10626939": { "compartment": "compartment_876", "id": "reaction_10626939", "reactome": "R-DDI-9653108", "name": "Raf dimer inhibitors bind RAF heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607149", "species_9657579" ], "products": [ "species_10607251" ], "modifiers": [], "additional_components": [ "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54VC0", "DDB_G0282895", "Q54WS5", "DDB_G0279417", "Q1ZXD6", "DDB_G0294533", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q54TM7", "DDB_G0281557", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438" ] }, "reaction_10606970": { "compartment": "compartment_70101", "id": "reaction_10606970", "reactome": "R-DDI-5672948", "name": "MARK3 phosphorylates KSR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606927", "species_113592" ], "products": [ "species_29370", "species_10606967" ], "modifiers": [ [ "species_10606927", "catalyst" ] ], "additional_components": [ "Q1ZXD6", "DDB_G0294533", "Q54WS5", "DDB_G0279417", "Q23915", "DDB_G0283391", "Q869X3", "DDB_G0282895", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54VC0", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q1ZXD6", "DDB_G0294533", "Q54RZ7", "DDB_G0282895", "Q869X3", "DDB_G0282895", "Q23915", "DDB_G0283391", "Q54TH6", "DDB_G0282895", "Q54GY6", "DDB_G0289859", "Q54VC0", "DDB_G0282895", "Q54H05", "DDB_G0289661", "Q54WS5", "DDB_G0279417", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304", "Q1ZXD6", "DDB_G0294533", "Q54WS5", "DDB_G0279417", "Q23915", "DDB_G0283391", "Q869X3", "DDB_G0282895", "Q54RZ7", "DDB_G0282895", "Q54TH6", "DDB_G0282895", "Q54GY6", "DDB_G0289859", "Q54H05", "DDB_G0289661", "Q54VC0", "DDB_G0282895", "Q54TA3", "DDB_G0281895", "Q54VU4", "DDB_G0280133", "Q55FV4", "DDB_G0267934", "Q54DF2", "DDB_G0292304" ] }, "reaction_10606562": { "compartment": "compartment_70101", "id": "reaction_10606562", "reactome": "R-DDI-5658424", "name": "KBTBD7:CUL3:RBX1 ubiquitinates NF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10606525" ], "products": [ "species_10606557" ], "modifiers": [ [ "species_10606559", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q5TJ65", "DDB_G0289541", "Q54WD0", "DDB_G0282941", "Q54Y08", "DDB_G0278483", "Q55AR6", "DDB_G0271750", "Q86JJ7", "DDB_G0282941", "Q8SSU4", "DDB_G0282941", "Q54Q13", "DDB_G0284177", "Q54RT3", "DDB_G0282941", "Q5TJ65", "DDB_G0289541", "Q54Y08", "DDB_G0278483", "Q55AR6", "DDB_G0271750", "Q54Q13", "DDB_G0284177", "Q86JJ7", "DDB_G0282941", "Q8SSU4", "DDB_G0282941", "Q54RT3", "DDB_G0282941", "Q54WD0", "DDB_G0282941", "Q55BF8", "DDB_G0271372", "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903" ] }, "reaction_10606532": { "compartment": "compartment_876", "id": "reaction_10606532", "reactome": "R-DDI-5658231", "name": "RAS GAPs stimulate RAS GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606529" ], "products": [ "species_10606527", "species_10585874" ], "modifiers": [ [ "species_10606529", "catalyst" ] ], "additional_components": [ "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54Q13", "DDB_G0284177", "Q86JJ7", "DDB_G0282941", "Q54WD0", "DDB_G0282941", "Q54Y08", "DDB_G0278483", "Q8SSU4", "DDB_G0282941", "Q54RT3", "DDB_G0282941", "Q55AR6", "DDB_G0271750", "Q5TJ65", "DDB_G0289541", "Q54Q13", "DDB_G0284177", "Q86JJ7", "DDB_G0282941", "Q54WD0", "DDB_G0282941", "Q54Y08", "DDB_G0278483", "Q8SSU4", "DDB_G0282941", "Q54RT3", "DDB_G0282941", "Q55AR6", "DDB_G0271750", "Q5TJ65", "DDB_G0289541", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29420", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54Q13", "DDB_G0284177", "Q86JJ7", "DDB_G0282941", "Q54WD0", "DDB_G0282941", "Q54Y08", "DDB_G0278483", "Q8SSU4", "DDB_G0282941", "Q54RT3", "DDB_G0282941", "Q55AR6", "DDB_G0271750", "Q5TJ65", "DDB_G0289541" ] }, "reaction_10606564": { "compartment": "compartment_70101", "id": "reaction_10606564", "reactome": "R-DDI-5658430", "name": "NF1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606557" ], "products": [ "species_10606507" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q5TJ65", "DDB_G0289541", "Q54Y08", "DDB_G0278483", "Q55AR6", "DDB_G0271750", "Q54Q13", "DDB_G0284177", "Q86JJ7", "DDB_G0282941", "Q8SSU4", "DDB_G0282941", "Q54RT3", "DDB_G0282941", "Q54WD0", "DDB_G0282941", "Q5TJ65", "DDB_G0289541", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10606566": { "compartment": "compartment_876", "id": "reaction_10606566", "reactome": "R-DDI-5658435", "name": "RAS GAPs bind RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606527", "species_10585144" ], "products": [ "species_10606529" ], "modifiers": [], "additional_components": [ "Q54Q13", "DDB_G0284177", "Q86JJ7", "DDB_G0282941", "Q54WD0", "DDB_G0282941", "Q54Y08", "DDB_G0278483", "Q8SSU4", "DDB_G0282941", "Q54RT3", "DDB_G0282941", "Q55AR6", "DDB_G0271750", "Q5TJ65", "DDB_G0289541", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "species_29438", "Q54Q13", "DDB_G0284177", "Q86JJ7", "DDB_G0282941", "Q54WD0", "DDB_G0282941", "Q54Y08", "DDB_G0278483", "Q8SSU4", "DDB_G0282941", "Q54RT3", "DDB_G0282941", "Q55AR6", "DDB_G0271750", "Q5TJ65", "DDB_G0289541" ] }, "reaction_10606568": { "compartment": "compartment_876", "id": "reaction_10606568", "reactome": "R-DDI-5658438", "name": "SPRED dimer binds NF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606523", "species_10606507" ], "products": [ "species_10606525" ], "modifiers": [], "additional_components": [ "Q54WD0", "DDB_G0282941", "Q54Y08", "DDB_G0278483", "Q55AR6", "DDB_G0271750", "Q86JJ7", "DDB_G0282941", "Q8SSU4", "DDB_G0282941", "Q54Q13", "DDB_G0284177", "Q54RT3", "DDB_G0282941", "Q5TJ65", "DDB_G0289541", "Q5TJ65", "DDB_G0289541", "Q54WD0", "DDB_G0282941", "Q54Y08", "DDB_G0278483", "Q55AR6", "DDB_G0271750", "Q86JJ7", "DDB_G0282941", "Q8SSU4", "DDB_G0282941", "Q54Q13", "DDB_G0284177", "Q54RT3", "DDB_G0282941" ] }, "reaction_10583296": { "compartment": "compartment_7660", "id": "reaction_10583296", "reactome": "R-DDI-112392", "name": "Resumption of elongation after recovery from pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583294" ], "products": [ "species_10583290" ], "modifiers": [], "additional_components": [ "Q75JA4", "DDB_G0271690", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10583300": { "compartment": "compartment_7660", "id": "reaction_10583300", "reactome": "R-DDI-112395", "name": "Abortive termination of elongation after arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583290" ], "products": [ "species_10583298" ], "modifiers": [], "additional_components": [ "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q75JA4", "DDB_G0271690", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10581640": { "compartment": "compartment_7660", "id": "reaction_10581640", "reactome": "R-DDI-75862", "name": "Fall Back to Closed Pre-initiation Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581630" ], "products": [ "species_10581638" ], "modifiers": [], "additional_components": [ "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54FD6", "DDB_G0290929", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307" ] }, "reaction_10581740": { "compartment": "compartment_7660", "id": "reaction_10581740", "reactome": "R-DDI-75891", "name": "Abortive Initiation After Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581738" ], "products": [ "species_10580922", "species_10580699", "species_10578889", "species_75897" ], "modifiers": [], "additional_components": [ "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10583308": { "compartment": "compartment_7660", "id": "reaction_10583308", "reactome": "R-DDI-112429", "name": "Formation of FACT complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583209", "species_10583204" ], "products": [ "species_10583211" ], "modifiers": [], "additional_components": [ "DDB_G0282677", "DDB_G0290331", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677" ] }, "reaction_10583310": { "compartment": "compartment_7660", "id": "reaction_10583310", "reactome": "R-DDI-112430", "name": "Formation of P-TEFb complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583129", "species_10583140" ], "products": [ "species_10583142" ], "modifiers": [], "additional_components": [ "DDB_G0273207", "Q54LJ0", "DDB_G0286617", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207" ] }, "reaction_10583312": { "compartment": "compartment_7660", "id": "reaction_10583312", "reactome": "R-DDI-112434", "name": "Formation of DSIF complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582382", "species_10583163" ], "products": [ "species_10583165" ], "modifiers": [], "additional_components": [ "DDB_G0287661", "DDB_G0285293", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661" ] }, "reaction_10583316": { "compartment": "compartment_7660", "id": "reaction_10583316", "reactome": "R-DDI-113409", "name": "Abortive termination of early transcription elongation by DSIF:NELF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583219" ], "products": [ "species_10583219" ], "modifiers": [], "additional_components": [ "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q75JA4", "DDB_G0271690", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q75JA4", "DDB_G0271690", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195" ] }, "reaction_10583318": { "compartment": "compartment_7660", "id": "reaction_10583318", "reactome": "R-DDI-113411", "name": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583290" ], "products": [ "species_10583294" ], "modifiers": [], "additional_components": [ "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q75JA4", "DDB_G0271690", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10583322": { "compartment": "compartment_7660", "id": "reaction_10583322", "reactome": "R-DDI-113413", "name": "TFIIS-mediated recovery of elongation from arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583290" ], "products": [ "species_10583290" ], "modifiers": [], "additional_components": [ "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10581628": { "compartment": "compartment_7660", "id": "reaction_10581628", "reactome": "R-DDI-75856", "name": "Abortive Initiation Before Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581626" ], "products": [ "species_10580910", "species_10580844", "species_10580922", "species_10580699", "species_10578889", "species_10580839", "species_110068" ], "modifiers": [], "additional_components": [ "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "DDB_G0290929", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343" ] }, "reaction_10583324": { "compartment": "compartment_7660", "id": "reaction_10583324", "reactome": "R-DDI-113414", "name": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10583290" ], "products": [ "species_10583290" ], "modifiers": [], "additional_components": [ "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241", "Q75JA4", "DDB_G0271690", "species_110614", "species_113592", "species_29494", "species_29438", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "Q54G78", "DDB_G0290331", "Q54S43", "DDB_G0282677", "Q55F33", "DDB_G0268922", "Q55CM9", "DDB_G0269992", "Q54Q05", "DDB_G0284201", "Q555G9", "DDB_G0274885", "Q55E33", "DDB_G0269412", "Q54LP1", "DDB_G0286523", "Q54Y92", "DDB_G0277841", "Q54MB8", "DDB_G0286051", "Q54S59", "DDB_G0282793", "Q86A81", "DDB_G0274327", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55F13", "DDB_G0268678", "Q54Q08", "DDB_G0284195", "Q55A48", "DDB_G0272354", "Q54NF2", "DDB_G0285293", "Q54K42", "DDB_G0287661", "Q54XU3", "DDB_G0278963", "Q54YG9", "DDB_G0278241" ] }, "reaction_10580926": { "compartment": "compartment_7660", "id": "reaction_10580926", "reactome": "R-DDI-73946", "name": "Abortive initiation after formation of the first phosphodiester bond", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580924" ], "products": [ "species_10580910", "species_10580844", "species_10580922", "species_10580699", "species_10578889", "species_10580839", "species_109877" ], "modifiers": [], "additional_components": [ "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54FD6", "DDB_G0290929", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "Q54DH8", "DDB_G0292242", "Q555L9", "DDB_G0274697", "Q54XM9", "DDB_G0278843", "Q55BH6", "DDB_G0271338", "Q54IW7", "DDB_G0288471", "Q54KH7", "DDB_G0287337", "Q55A39", "DDB_G0272360", "Q54X70", "DDB_G0279179", "C7G081", "DDB_G0292724", "Q54CN8", "DDB_G0292838", "P26355", "DDB_G0275617", "DDB_G0290929", "Q557M8", "DDB_G0273525", "Q54KJ8", "DDB_G0287307", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "P35084", "DDB_G0279193", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54G80", "DDB_G0290327", "Q54ND1", "DDB_G0285343" ] }, "reaction_10626417": { "compartment": "compartment_17938", "id": "reaction_10626417", "reactome": "R-DDI-9639287", "name": "SESN1,2 binds L-leucine and dissociates from GATOR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626411", "species_29588" ], "products": [ "species_10626413", "species_10626415" ], "modifiers": [], "additional_components": [ "Q54WU6", "DDB_G0279427", "Q86K39", "DDB_G0277257", "Q54JS5", "DDB_G0287817", "Q54DS4", "DDB_G0292056", "Q54DS8", "DDB_G0292052", "Q551B5", "DDB_G0276673", "Q54XA2", "DDB_G0279099", "Q55BD9", "DDB_G0271288", "Q54UN5", "DDB_G0280947", "Q54NW3", "DDB_G0284957", "Q54Y15", "DDB_G0278475", "Q86IH5", "DDB_G0272696", "Q55DE8", "DDB_G0269680", "Q54XA2", "DDB_G0279099", "Q55BD9", "DDB_G0271288", "Q54UN5", "DDB_G0280947", "Q54NW3", "DDB_G0284957", "Q54Y15", "DDB_G0278475", "Q86IH5", "DDB_G0272696", "Q55DE8", "DDB_G0269680", "Q86K39", "DDB_G0277257", "Q54JS5", "DDB_G0287817", "Q54DS4", "DDB_G0292056", "Q54DS8", "DDB_G0292052", "Q551B5", "DDB_G0276673", "species_29588", "Q54WU6", "DDB_G0279427" ] }, "reaction_10626343": { "compartment": "compartment_17938", "id": "reaction_10626343", "reactome": "R-DDI-9639286", "name": "RRAGC,D exchanges GTP for GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584158", "species_10626430" ], "products": [ "species_10626432" ], "modifiers": [], "additional_components": [ "Q54DD9", "DDB_G0292318", "species_29438", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q55AH5", "DDB_G0271882", "Q86A77", "DDB_G0274331", "O00780", "DDB_G0275701", "Q54Z13", "DDB_G0277971", "Q76NU1", "DDB_G0277401", "P54648", "DDB_G0284473", "Q86AS7", "DDB_G0274141", "Q54E04", "DDB_G0291858", "P54642", "DDB_G0274381", "P54641", "DDB_G0273071", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q55AH5", "DDB_G0271882", "Q86A77", "DDB_G0274331", "O00780", "DDB_G0275701", "Q54Z13", "DDB_G0277971", "Q76NU1", "DDB_G0277401", "P54648", "DDB_G0284473", "Q86AS7", "DDB_G0274141", "Q54E04", "DDB_G0291858", "P54642", "DDB_G0274381", "P54641", "DDB_G0273071", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q54DD9", "DDB_G0292318" ] }, "reaction_10626428": { "compartment": "compartment_17938", "id": "reaction_10626428", "reactome": "R-DDI-9640167", "name": "RRAGA,B exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10626421" ], "products": [ "species_29420", "species_10626425" ], "modifiers": [ [ "species_10626421", "catalyst" ] ], "additional_components": [ "species_29468", "Q54IK1", "DDB_G0288701", "species_29420", "Q54PK6", "DDB_G0284495", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q55AH5", "DDB_G0271882", "Q86A77", "DDB_G0274331", "O00780", "DDB_G0275701", "Q54Z13", "DDB_G0277971", "Q76NU1", "DDB_G0277401", "P54648", "DDB_G0284473", "Q86AS7", "DDB_G0274141", "Q54E04", "DDB_G0291858", "P54642", "DDB_G0274381", "P54641", "DDB_G0273071", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "species_29468", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q55AH5", "DDB_G0271882", "Q86A77", "DDB_G0274331", "O00780", "DDB_G0275701", "Q54Z13", "DDB_G0277971", "Q76NU1", "DDB_G0277401", "P54648", "DDB_G0284473", "Q86AS7", "DDB_G0274141", "Q54E04", "DDB_G0291858", "P54642", "DDB_G0274381", "P54641", "DDB_G0273071", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "species_29468", "Q54IK1", "DDB_G0288701", "species_29420", "Q54PK6", "DDB_G0284495", "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q55AH5", "DDB_G0271882", "Q86A77", "DDB_G0274331", "O00780", "DDB_G0275701", "Q54Z13", "DDB_G0277971", "Q76NU1", "DDB_G0277401", "P54648", "DDB_G0284473", "Q86AS7", "DDB_G0274141", "Q54E04", "DDB_G0291858", "P54642", "DDB_G0274381", "P54641", "DDB_G0273071", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567" ] }, "reaction_10606133": { "compartment": "compartment_7660", "id": "reaction_10606133", "reactome": "R-DDI-5635854", "name": "GLI2,3 are degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606131" ], "products": [ "species_10576865", "species_10606129" ], "modifiers": [ [ "species_10585327", "catalyst" ] ], "additional_components": [ "Q54D90", "DDB_G0292428", "Q54WU7", "DDB_G0292428", "Q55E93", "DDB_G0269338", "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54D90", "DDB_G0292428", "Q54WU7", "DDB_G0292428", "Q55E93", "DDB_G0269338", "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903", "Q27563", "DDB_G0267408", "P02889", "DDB_G0272564", "P34119", "DDB_G0280969", "Q552Y8", "DDB_G0275753", "Q55G04", "DDB_G0268538", "Q967U1", "DDB_G0285099", "Q54XM7", "DDB_G0278847", "P34120", "DDB_G0272831", "Q86A21", "DDB_G0272969", "Q54S82", "DDB_G0282617", "Q54QR2", "DDB_G0283679", "Q55DY7", "DDB_G0269472", "Q55D66", "DDB_G0269772", "Q556Q0", "DDB_G0273163", "Q54BC8", "DDB_G0293784", "Q55GJ6", "DDB_G0267390", "Q55BV5", "DDB_G0270784", "Q86JA1", "DDB_G0276917", "Q54PN7", "DDB_G0284415", "P34123", "DDB_G0289003", "P34124", "DDB_G0292382", "Q54PJ1", "DDB_G0284517", "Q54JM5", "DDB_G0287953", "Q54HW1", "DDB_G0289189", "Q54UB5", "DDB_G0281315", "Q54UJ0", "DDB_G0281051", "Q54NQ0", "DDB_G0285105", "Q54BC6", "DDB_G0293752", "Q1ZXD3", "DDB_G0288621", "Q553E0", "DDB_G0275775", "Q86IJ1", "DDB_G0272566", "Q559F4", "DDB_G0272951", "Q27562", "DDB_G0282363", "Q55C75", "DDB_G0270188", "Q54DM7", "DDB_G0292122", "Q54WI8", "DDB_G0279633" ] }, "reaction_10606140": { "compartment": "compartment_7660", "id": "reaction_10606140", "reactome": "R-DDI-5635856", "name": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10606137", "species_10576865" ], "products": [ "species_10606131" ], "modifiers": [ [ "species_10606137", "catalyst" ] ], "additional_components": [ "Q54D90", "DDB_G0292428", "Q54WU7", "DDB_G0292428", "Q55E93", "DDB_G0269338", "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54D90", "DDB_G0292428", "Q54WU7", "DDB_G0292428", "Q55E93", "DDB_G0269338", "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903", "Q54D90", "DDB_G0292428", "Q54WU7", "DDB_G0292428", "Q55E93", "DDB_G0269338", "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903" ] }, "reaction_10595044": { "compartment": "compartment_70101", "id": "reaction_10595044", "reactome": "R-DDI-936563", "name": "ISGylation of DDX58", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10595002", "species_10595040" ], "products": [ "species_10595042" ], "modifiers": [], "additional_components": [ "DDB_G0294407", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q55C16", "DDB_G0270272", "Q54D12", "DDB_G0292586", "Q54NH2", "DDB_G0292586", "Q54Q67", "DDB_G0292586", "Q54CI1", "DDB_G0292984", "Q54TE1", "DDB_G0281833", "Q55C16", "DDB_G0270272", "Q86L44", "DDB_G0294407" ] }, "reaction_10605345": { "compartment": "compartment_12045", "id": "reaction_10605345", "reactome": "R-DDI-5362412", "name": "SYVN1 ubiquitinates Hh C-terminal fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10605338" ], "products": [ "species_10605342" ], "modifiers": [ [ "species_10605338", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q86H64", "DDB_G0275851", "Q54IC9", "DDB_G0288833", "P90532", "DDB_G0288065", "Q54JQ6", "DDB_G0287847", "Q55E19", "DDB_G0269430", "Q54IC9", "DDB_G0288833", "P90532", "DDB_G0288065", "Q54JQ6", "DDB_G0287847", "Q55E19", "DDB_G0269430", "Q86H64", "DDB_G0275851", "Q86H64", "DDB_G0275851", "Q54IC9", "DDB_G0288833", "P90532", "DDB_G0288065", "Q54JQ6", "DDB_G0287847", "Q55E19", "DDB_G0269430" ] }, "reaction_10593912": { "compartment": "compartment_876", "id": "reaction_10593912", "reactome": "R-DDI-507868", "name": "Aquaporins passively transport water into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10593909", "catalyst" ] ], "additional_components": [ "Q9U8P7", "DDB_G0267378", "Q54WT8", "DDB_G0279443", "Q54FQ9", "DDB_G0290691", "Q54V53", "DDB_G0280537" ] }, "reaction_10593914": { "compartment": "compartment_876", "id": "reaction_10593914", "reactome": "R-DDI-507870", "name": "Aquaporins passively transport water out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10593909", "catalyst" ] ], "additional_components": [ "Q9U8P7", "DDB_G0267378", "Q54WT8", "DDB_G0279443", "Q54FQ9", "DDB_G0290691", "Q54V53", "DDB_G0280537" ] }, "reaction_10587219": { "compartment": "compartment_876", "id": "reaction_10587219", "reactome": "R-DDI-199443", "name": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587026", "species_10587009" ], "products": [ "species_10587028" ], "modifiers": [], "additional_components": [ "DDB_G0273293", "species_179838", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_179838", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "Q556W3", "DDB_G0273293" ] }, "reaction_10619666": { "compartment": "compartment_984", "id": "reaction_10619666", "reactome": "R-DDI-8862300", "name": "LYZ binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6789198", "species_10614528" ], "products": [ "species_10619664" ], "modifiers": [], "additional_components": [ "Q54F36", "DDB_G0291137", "Q54XV8", "DDB_G0278563", "Q8MML4", "DDB_G0274551", "Q54F36", "DDB_G0291137", "Q54XV8", "DDB_G0278563", "Q8MML4", "DDB_G0274551", "species_6789198" ] }, "reaction_10619669": { "compartment": "compartment_984", "id": "reaction_10619669", "reactome": "R-DDI-8862320", "name": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10619664" ], "products": [ "species_6788991", "species_6788982" ], "modifiers": [ [ "species_10619664", "catalyst" ] ], "additional_components": [ "Q54F36", "DDB_G0291137", "Q54XV8", "DDB_G0278563", "Q8MML4", "DDB_G0274551", "species_6789198", "species_1236719", "CHEBI:21615", "Q54F36", "DDB_G0291137", "Q54XV8", "DDB_G0278563", "Q8MML4", "DDB_G0274551", "species_6789198" ] }, "reaction_10616763": { "compartment": "compartment_984", "id": "reaction_10616763", "reactome": "R-DDI-6807585", "name": "BPI binds LPS on the bacterial surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803081", "species_10584365" ], "products": [ "species_10616761" ], "modifiers": [], "additional_components": [ "DDB_G0271242", "Q55BA2", "DDB_G0271242", "species_166005" ] }, "reaction_10603621": { "compartment": "compartment_7660", "id": "reaction_10603621", "reactome": "R-DDI-4411373", "name": "NLK translocates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603605" ], "products": [ "species_10603619" ], "modifiers": [], "additional_components": [ "Q554L2", "DDB_G0280855", "Q54V35", "DDB_G0280855", "P42525", "DDB_G0286353", "Q54V83", "DDB_G0280855", "Q54US6", "DDB_G0280855", "P42525", "DDB_G0286353", "Q54US6", "DDB_G0280855", "Q54V35", "DDB_G0280855", "Q54V83", "DDB_G0280855", "Q554L2", "DDB_G0280855" ] }, "reaction_10603684": { "compartment": "compartment_70101", "id": "reaction_10603684", "reactome": "R-DDI-4551465", "name": "Translocation of NFATC1:CaN:CaM to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10603678" ], "products": [ "species_10603682" ], "modifiers": [], "additional_components": [ "species_74112", "Q55G87", "DDB_G0267446", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "species_29426", "Q7YSW8", "DDB_G0276883", "CHEBI:29034", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "species_74112", "Q7YSW8", "DDB_G0276883", "CHEBI:29034", "species_29426", "Q55G87", "DDB_G0267446" ] }, "reaction_10603543": { "compartment": "compartment_70101", "id": "reaction_10603543", "reactome": "R-DDI-4086392", "name": "PDE6 hydrolyses cGMP to GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30991", "species_29356" ], "products": [ "species_113578" ], "modifiers": [ [ "species_10603540", "catalyst" ] ], "additional_components": [ "B0G0Y8", "DDB_G0268634", "species_29438", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343" ] }, "reaction_10622131": { "compartment": "compartment_70101", "id": "reaction_10622131", "reactome": "R-DDI-8875871", "name": "SLC26A11 transports SO4(2-) from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648" ], "products": [ "species_174375" ], "modifiers": [ [ "species_10622128", "catalyst" ] ], "additional_components": [ "DDB_G0268074" ] }, "reaction_10591543": { "compartment": "compartment_876", "id": "reaction_10591543", "reactome": "R-DDI-427666", "name": "SLC26A3,6 exchange Cl- for HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_111627" ], "products": [ "species_425425", "species_352022" ], "modifiers": [ [ "species_10591540", "catalyst" ] ], "additional_components": [ "Q55FK8", "DDB_G0286611", "B0G157", "DDB_G0286611" ] }, "reaction_10591526": { "compartment": "compartment_876", "id": "reaction_10591526", "reactome": "R-DDI-427570", "name": "Group 3 - Selective Cl- transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10591523", "catalyst" ] ], "additional_components": [ "B0G157", "DDB_G0286611", "Q55FK8", "DDB_G0286611" ] }, "reaction_10605910": { "compartment": "compartment_70101", "id": "reaction_10605910", "reactome": "R-DDI-5627802", "name": "SLC26A4 transports I- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209785" ], "products": [ "species_209818" ], "modifiers": [ [ "species_10605907", "catalyst" ] ], "additional_components": [ "Q55FK8", "DDB_G0286611", "B0G157", "DDB_G0286611" ] }, "reaction_10605187": { "compartment": "compartment_70101", "id": "reaction_10605187", "reactome": "R-DDI-5340130", "name": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428040", "species_5673778" ], "products": [ "species_70106", "species_379444" ], "modifiers": [ [ "species_10605184", "catalyst" ] ], "additional_components": [ "DDB_G0279445" ] }, "reaction_10591393": { "compartment": "compartment_876", "id": "reaction_10591393", "reactome": "R-DDI-425994", "name": "Na+/H+ exchanger transport (at cell membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_74113" ], "products": [ "species_351626", "species_83910" ], "modifiers": [ [ "species_10591390", "catalyst" ] ], "additional_components": [ "Q54TB5", "DDB_G0281877", "Q552S0", "DDB_G0275711" ] }, "reaction_10591341": { "compartment": "compartment_172574", "id": "reaction_10591341", "reactome": "R-DDI-425965", "name": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425999", "species_83910" ], "products": [ "species_425977", "species_70106" ], "modifiers": [ [ "species_10591338", "catalyst" ] ], "additional_components": [ "Q54TB5", "DDB_G0281877", "Q552S0", "DDB_G0275711" ] }, "reaction_10591358": { "compartment": "compartment_171062", "id": "reaction_10591358", "reactome": "R-DDI-425983", "name": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425978", "species_83910" ], "products": [ "species_70106", "species_425971" ], "modifiers": [ [ "species_10591355", "catalyst" ] ], "additional_components": [ "Q552S0", "DDB_G0275711", "Q54TB5", "DDB_G0281877" ] }, "reaction_10591406": { "compartment": "compartment_20699", "id": "reaction_10591406", "reactome": "R-DDI-426015", "name": "Na+/H+ exchanger transport (at trans-golgi membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425969", "species_83910" ], "products": [ "species_70106", "species_425958" ], "modifiers": [ [ "species_10591403", "catalyst" ] ], "additional_components": [ "Q54TB5", "DDB_G0281877", "Q552S0", "DDB_G0275711" ] }, "reaction_10591664": { "compartment": "compartment_876", "id": "reaction_10591664", "reactome": "R-DDI-428609", "name": "Type I Na+-coupled phosphate co-transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109277", "species_74113" ], "products": [ "species_29372", "species_83910" ], "modifiers": [ [ "species_10591661", "catalyst" ] ], "additional_components": [ "Q54UX4", "DDB_G0280761", "Q54W37", "DDB_G0280761" ] }, "reaction_10622115": { "compartment": "compartment_70101", "id": "reaction_10622115", "reactome": "R-DDI-8875623", "name": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_70106" ], "products": [ "species_113529", "species_113552" ], "modifiers": [ [ "species_10622110", "catalyst" ] ], "additional_components": [ "DDB_G0283329" ] }, "reaction_10591574": { "compartment": "compartment_201753", "id": "reaction_10591574", "reactome": "R-DDI-428052", "name": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_428548" ], "products": [ "species_70106", "species_428614" ], "modifiers": [ [ "species_10591571", "catalyst" ] ], "additional_components": [ "Q54UX4", "DDB_G0280761", "Q54W37", "DDB_G0280761" ] }, "reaction_10593024": { "compartment": "compartment_70101", "id": "reaction_10593024", "reactome": "R-DDI-450095", "name": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10586023", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10624195": { "compartment": "compartment_70101", "id": "reaction_10624195", "reactome": "R-DDI-8981570", "name": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10624192", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10591744": { "compartment": "compartment_876", "id": "reaction_10591744", "reactome": "R-DDI-428779", "name": "GLUT7 and GLUT11 transport glucose and fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428819" ], "products": [ "species_428802" ], "modifiers": [ [ "species_10591741", "catalyst" ] ], "additional_components": [ "species_70113", "species_29532", "species_70113", "species_29532", "Q54Z55", "DDB_G0277773", "Q54CM5", "DDB_G0292814" ] }, "reaction_10591780": { "compartment": "compartment_876", "id": "reaction_10591780", "reactome": "R-DDI-429094", "name": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10591777", "catalyst" ] ], "additional_components": [ "Q54M69", "DDB_G0286151", "Q54UC8", "DDB_G0281155" ] }, "reaction_10624197": { "compartment": "compartment_70101", "id": "reaction_10624197", "reactome": "R-DDI-8981574", "name": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10586023", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10605166": { "compartment": "compartment_70101", "id": "reaction_10605166", "reactome": "R-DDI-5339524", "name": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10593015", "catalyst" ], [ "species_113592", "inhibitor" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10591761": { "compartment": "compartment_876", "id": "reaction_10591761", "reactome": "R-DDI-429036", "name": "SLC2A9 transports Fru, Glc, urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429078" ], "products": [ "species_429148" ], "modifiers": [ [ "species_10591758", "catalyst" ] ], "additional_components": [ "species_70113", "species_30034", "species_29532", "species_70113", "species_30034", "species_29532", "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10624179": { "compartment": "compartment_70101", "id": "reaction_10624179", "reactome": "R-DDI-8981553", "name": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10624176", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10593019": { "compartment": "compartment_70101", "id": "reaction_10593019", "reactome": "R-DDI-450088", "name": "GLUT1 tetramer binds 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10593015" ], "products": [ "species_10593017" ], "modifiers": [], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773", "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773", "species_113592" ] }, "reaction_10624184": { "compartment": "compartment_70101", "id": "reaction_10624184", "reactome": "R-DDI-8981564", "name": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10624181", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814" ] }, "reaction_10622136": { "compartment": "compartment_70101", "id": "reaction_10622136", "reactome": "R-DDI-8875902", "name": "SLC45A3 transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10622133", "catalyst" ] ], "additional_components": [ "DDB_G0276801" ] }, "reaction_10593021": { "compartment": "compartment_70101", "id": "reaction_10593021", "reactome": "R-DDI-450092", "name": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593017" ], "products": [ "species_113592", "species_10593015" ], "modifiers": [], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773", "species_113592", "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10622268": { "compartment": "compartment_70101", "id": "reaction_10622268", "reactome": "R-DDI-8876319", "name": "SLC50A1 transports Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10622265", "catalyst" ] ], "additional_components": [ "DDB_G0287763" ] }, "reaction_10623330": { "compartment": "compartment_13231", "id": "reaction_10623330", "reactome": "R-DDI-8944457", "name": "MAF1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623321" ], "products": [ "species_10623319" ], "modifiers": [ [ "species_10584242", "inhibitor" ] ], "additional_components": [ "DDB_G0278673", "DDB_G0278673", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318" ] }, "reaction_10623328": { "compartment": "compartment_70101", "id": "reaction_10623328", "reactome": "R-DDI-8944454", "name": "mTORC1 phosphorylates MAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623321", "species_113592" ], "products": [ "species_10623326", "species_29370" ], "modifiers": [ [ "species_10584242", "catalyst" ] ], "additional_components": [ "DDB_G0278673", "DDB_G0278673", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318" ] }, "reaction_10616691": { "compartment": "compartment_70101", "id": "reaction_10616691", "reactome": "R-DDI-6807105", "name": "Monoubiquitinated PTEN translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616685" ], "products": [ "species_10616689" ], "modifiers": [], "additional_components": [ "DDB_G0286557", "DDB_G0286557" ] }, "reaction_10616696": { "compartment": "compartment_7660", "id": "reaction_10616696", "reactome": "R-DDI-6807118", "name": "USP7 deubiquitinates monoubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10616689" ], "products": [ "species_10616693", "species_10576865" ], "modifiers": [ [ "species_10602170", "catalyst" ], [ "species_10601869", "inhibitor" ] ], "additional_components": [ "DDB_G0286557", "DDB_G0286557", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0276443", "DDB_G0285989" ] }, "reaction_10616699": { "compartment": "compartment_7660", "id": "reaction_10616699", "reactome": "R-DDI-6807126", "name": "Deubiquitinated PTEN translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616693" ], "products": [ "species_10587224" ], "modifiers": [], "additional_components": [ "DDB_G0286557", "DDB_G0286557" ] }, "reaction_10618691": { "compartment": "compartment_70101", "id": "reaction_10618691", "reactome": "R-DDI-8850992", "name": "Proteasome degrades polyubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618689" ], "products": [ "species_10577037" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q8T9S7", "DDB_G0286557", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10623382": { "compartment": "compartment_70101", "id": "reaction_10623382", "reactome": "R-DDI-8948800", "name": "TNKS and TNKS2 PARylate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587224", "species_29360" ], "products": [ "species_197277", "species_10623370" ], "modifiers": [ [ "species_10623379", "catalyst" ] ], "additional_components": [ "DDB_G0286557", "DDB_G0286557", "Q86J21", "DDB_G0274293" ] }, "reaction_10618679": { "compartment": "compartment_70101", "id": "reaction_10618679", "reactome": "R-DDI-8850945", "name": "Casein kinase II phosphorylates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10587224" ], "products": [ "species_29370", "species_10618677" ], "modifiers": [ [ "species_10601344", "catalyst" ] ], "additional_components": [ "DDB_G0286557", "DDB_G0286557", "Q54PF1", "DDB_G0284601", "Q02720", "DDB_G0276885", "Q54LR6", "DDB_G0286481" ] }, "reaction_10623365": { "compartment": "compartment_70101", "id": "reaction_10623365", "reactome": "R-DDI-8948757", "name": "AKT phosphorylates MKRN1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10596354" ], "products": [ "species_29370", "species_10623363" ], "modifiers": [ [ "species_10586959", "catalyst" ] ], "additional_components": [ "DDB_G0281657", "DDB_G0281657", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795" ] }, "reaction_10616726": { "compartment": "compartment_70101", "id": "reaction_10616726", "reactome": "R-DDI-6807206", "name": "USP13 and OTUD3 deubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616716", "species_29356" ], "products": [ "species_10577037", "species_10587224" ], "modifiers": [ [ "species_10616723", "catalyst" ] ], "additional_components": [ "DDB_G0286557", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0286557", "Q55FY4", "DDB_G0267906", "P54201", "DDB_G0291239" ] }, "reaction_10616713": { "compartment": "compartment_70101", "id": "reaction_10616713", "reactome": "R-DDI-6807134", "name": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10587224" ], "products": [ "species_10616702" ], "modifiers": [ [ "species_10616710", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0286557", "DDB_G0286557", "C7G034", "DDB_G0285063", "Q54QF1", "DDB_G0283983" ] }, "reaction_10623368": { "compartment": "compartment_70101", "id": "reaction_10623368", "reactome": "R-DDI-8948775", "name": "MKRN1 polyubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10577037", "species_10587224" ], "products": [ "species_10616716" ], "modifiers": [ [ "species_10623363", "catalyst" ] ], "additional_components": [ "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0286557", "DDB_G0286557", "DDB_G0281657" ] }, "reaction_10593296": { "compartment": "compartment_70101", "id": "reaction_10593296", "reactome": "R-DDI-450488", "name": "BRF1 Complex recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593226", "species_10591881", "species_10591977", "species_10593284", "species_10591874" ], "products": [ "species_10593294" ], "modifiers": [], "additional_components": [ "DDB_G0289921", "DDB_G0283315", "Q55BJ2", "DDB_G0271100", "Q54VM4", "DDB_G0280251", "Q54CU6", "DDB_G0292692", "Q55BB0", "DDB_G0271396", "Q54EU6", "DDB_G0291328", "Q54Q83", "DDB_G0284053", "Q54EV5", "DDB_G0291310", "Q54N99", "DDB_G0285377", "Q54BH9", "DDB_G0293614", "Q7KWX9", "DDB_G0276783", "Q54MG5", "DDB_G0285973", "DDB_G0287243", "Q54KM1", "DDB_G0287243", "Q54MG5", "DDB_G0285973", "Q55BJ2", "DDB_G0271100", "Q54VM4", "DDB_G0280251", "Q54CU6", "DDB_G0292692", "Q55BB0", "DDB_G0271396", "Q54EU6", "DDB_G0291328", "Q54Q83", "DDB_G0284053", "Q54EV5", "DDB_G0291310", "Q54N99", "DDB_G0285377", "Q54BH9", "DDB_G0293614", "Q7KWX9", "DDB_G0276783", "Q54R87", "DDB_G0283315", "Q54GU2", "DDB_G0289921" ] }, "reaction_10593303": { "compartment": "compartment_70101", "id": "reaction_10593303", "reactome": "R-DDI-450490", "name": "Protein Kinase B/Akt phosphorylates BRF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10593284" ], "products": [ "species_29370", "species_10593300" ], "modifiers": [ [ "species_10586949", "catalyst" ] ], "additional_components": [ "Q54MG5", "DDB_G0285973", "Q54MG5", "DDB_G0285973", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795" ] }, "reaction_10593305": { "compartment": "compartment_70101", "id": "reaction_10593305", "reactome": "R-DDI-450517", "name": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_450523", "species_10593282" ], "products": [ "species_10593284" ], "modifiers": [], "additional_components": [ "DDB_G0285973", "Q54MG5", "DDB_G0285973" ] }, "reaction_10586026": { "compartment": "compartment_876", "id": "reaction_10586026", "reactome": "R-DDI-189242", "name": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189246" ], "products": [ "species_189219" ], "modifiers": [ [ "species_10586023", "catalyst" ] ], "additional_components": [ "species_70113", "CHEBI:17118", "species_29532", "CHEBI:17118", "species_70113", "species_29532", "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10586015": { "compartment": "compartment_876", "id": "reaction_10586015", "reactome": "R-DDI-189222", "name": "SLC2A5 transports fructose from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189049" ], "products": [ "species_29532" ], "modifiers": [ [ "species_10586012", "catalyst" ] ], "additional_components": [ "Q54CM5", "DDB_G0292814", "Q54Z55", "DDB_G0277773" ] }, "reaction_10627366": { "compartment": "compartment_70101", "id": "reaction_10627366", "reactome": "R-DDI-9687625", "name": "ATP binds MLKL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10604755" ], "products": [ "species_10627364" ], "modifiers": [], "additional_components": [ "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54TM7", "DDB_G0281557", "species_113592", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417" ] }, "reaction_10627370": { "compartment": "compartment_70101", "id": "reaction_10627370", "reactome": "R-DDI-9687638", "name": "MLKL binds IP4, IP5 and IP6 ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994146", "species_10604761", "species_1629770", "species_994141" ], "products": [ "species_10627368" ], "modifiers": [], "additional_components": [ "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "species_994141", "species_1629770", "species_994146" ] }, "reaction_10611280": { "compartment": "compartment_70101", "id": "reaction_10611280", "reactome": "R-DDI-5692462", "name": "ATP13A1 transports Mn2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29418", "species_113592" ], "products": [ "species_29372", "species_29370", "species_1981162" ], "modifiers": [ [ "species_10611277", "catalyst" ] ], "additional_components": [ "DDB_G0293004" ] }, "reaction_10595064": { "compartment": "compartment_20699", "id": "reaction_10595064", "reactome": "R-DDI-936895", "name": "ATP7B transports cytosolic Cu2+ to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_209799" ], "products": [ "species_29372", "species_936901", "species_29370" ], "modifiers": [ [ "species_10595061", "catalyst" ] ], "additional_components": [ "Q55DN5", "DDB_G0284141", "Q54Q77", "DDB_G0284141", "Q557B5", "DDB_G0284141" ] }, "reaction_10595352": { "compartment": "compartment_70101", "id": "reaction_10595352", "reactome": "R-DDI-947591", "name": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_947588", "species_113592" ], "products": [ "species_29372", "species_29370", "species_947594" ], "modifiers": [ [ "species_10595291", "catalyst" ] ], "additional_components": [ "species_1500646", "species_1500581", "species_1500581", "species_1500646", "Q54U08", "DDB_G0281401", "Q86H52", "DDB_G0286891", "Q551T0", "DDB_G0286891", "Q553A4", "DDB_G0286891", "Q54L55", "DDB_G0286891", "Q55E61", "DDB_G0286891" ] }, "reaction_10611291": { "compartment": "compartment_70101", "id": "reaction_10611291", "reactome": "R-DDI-5692480", "name": "ATP13A2 transports cations from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5692450" ], "products": [ "species_29372", "species_29370", "species_5692484" ], "modifiers": [ [ "species_10611288", "catalyst" ] ], "additional_components": [ "Q54NW5", "DDB_G0284955", "Q54P22", "DDB_G0284955", "Q54X63", "DDB_G0284955" ] }, "reaction_10605018": { "compartment": "compartment_70101", "id": "reaction_10605018", "reactome": "R-DDI-5251989", "name": "ATP13A4,5 transport divalent ions from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5252122", "species_113592" ], "products": [ "species_29372", "species_29370", "species_5252016" ], "modifiers": [ [ "species_10605015", "catalyst" ] ], "additional_components": [ "Q54P22", "DDB_G0284955", "Q54X63", "DDB_G0284955", "Q54NW5", "DDB_G0284955" ] }, "reaction_10600371": { "compartment": "compartment_161320", "id": "reaction_10600371", "reactome": "R-DDI-2130706", "name": "MHC class II antigen processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2213225" ], "products": [ "species_2213226" ], "modifiers": [ [ "species_10600368", "catalyst" ] ], "additional_components": [ "O76856", "DDB_G0279411", "Q54UH2", "DDB_G0282991", "Q23894", "DDB_G0283867", "Q54RQ2", "DDB_G0282991", "Q54UH3", "DDB_G0282991", "Q86KD4", "DDB_G0282991", "P04989", "DDB_G0279799", "Q54TR1", "DDB_G0281605", "P04988", "DDB_G0290957" ] }, "reaction_10605435": { "compartment": "compartment_70101", "id": "reaction_10605435", "reactome": "R-DDI-5578910", "name": "KCNK dimers transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10605432", "catalyst" ] ], "additional_components": [ "Q86K40", "DDB_G0277255", "Q8T268", "DDB_G0277255" ] }, "reaction_10612564": { "compartment": "compartment_1660541", "id": "reaction_10612564", "reactome": "R-DDI-6784729", "name": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612534" ], "products": [ "species_10612562" ], "modifiers": [], "additional_components": [ "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54H39", "DDB_G0289721", "Q54X82", "DDB_G0279141", "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54X82", "DDB_G0279141", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403" ] }, "reaction_10622308": { "compartment": "compartment_161320", "id": "reaction_10622308", "reactome": "R-DDI-8876472", "name": "NPC2 binds CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848047", "species_10622304" ], "products": [ "species_10622306" ], "modifiers": [], "additional_components": [ "Q54SW1", "DDB_G0287185", "Q54MV4", "DDB_G0287185", "Q54SZ8", "DDB_G0287185", "Q54SW2", "DDB_G0287185", "Q54TL9", "DDB_G0287185", "Q54SZ9", "DDB_G0287185", "Q54KP7", "DDB_G0287185", "Q55BL4", "DDB_G0287185", "Q54YD2", "DDB_G0287185", "Q54SW1", "DDB_G0287185", "Q54MV4", "DDB_G0287185", "Q54SZ8", "DDB_G0287185", "Q54SW2", "DDB_G0287185", "Q54TL9", "DDB_G0287185", "Q54SZ9", "DDB_G0287185", "Q54KP7", "DDB_G0287185", "Q55BL4", "DDB_G0287185", "Q54YD2", "DDB_G0287185", "species_216762" ] }, "reaction_10612566": { "compartment": "compartment_1660541", "id": "reaction_10612566", "reactome": "R-DDI-6784738", "name": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612562" ], "products": [ "species_10612560" ], "modifiers": [], "additional_components": [ "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54X82", "DDB_G0279141", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54X82", "DDB_G0279141", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403" ] }, "reaction_10622314": { "compartment": "compartment_161320", "id": "reaction_10622314", "reactome": "R-DDI-8876484", "name": "NPC2 transfers CHOL to NPC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622310", "species_10622306" ], "products": [ "species_10622312", "species_10622304" ], "modifiers": [], "additional_components": [ "DDB_G0269158", "Q54SW1", "DDB_G0287185", "Q54MV4", "DDB_G0287185", "Q54SZ8", "DDB_G0287185", "Q54SW2", "DDB_G0287185", "Q54TL9", "DDB_G0287185", "Q54SZ9", "DDB_G0287185", "Q54KP7", "DDB_G0287185", "Q55BL4", "DDB_G0287185", "Q54YD2", "DDB_G0287185", "species_216762", "Q9TVK6", "DDB_G0269158", "species_216762", "Q54SW1", "DDB_G0287185", "Q54MV4", "DDB_G0287185", "Q54SZ8", "DDB_G0287185", "Q54SW2", "DDB_G0287185", "Q54TL9", "DDB_G0287185", "Q54SZ9", "DDB_G0287185", "Q54KP7", "DDB_G0287185", "Q55BL4", "DDB_G0287185", "Q54YD2", "DDB_G0287185" ] }, "reaction_10617819": { "compartment": "compartment_70101", "id": "reaction_10617819", "reactome": "R-DDI-6813720", "name": "NCEH1 hydrolyzes cholesterol esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_163579" ], "products": [ "species_8876730", "species_216762" ], "modifiers": [ [ "species_10617816", "catalyst" ] ], "additional_components": [ "DDB_G0283819" ] }, "reaction_10622316": { "compartment": "compartment_12045", "id": "reaction_10622316", "reactome": "R-DDI-8876485", "name": "CHOL translocates from lysosome membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10622312" ], "products": [ "species_193384", "species_10622310" ], "modifiers": [], "additional_components": [ "Q9TVK6", "DDB_G0269158", "species_216762", "DDB_G0269158" ] }, "reaction_10622364": { "compartment": "compartment_12045", "id": "reaction_10622364", "reactome": "R-DDI-8876696", "name": "SOAT1,2 transfer acyl group to CHOL forming CHEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193384", "species_1500578" ], "products": [ "species_8876704", "species_76194" ], "modifiers": [ [ "species_10622361", "catalyst" ] ], "additional_components": [ "Q551G5", "DDB_G0276523" ] }, "reaction_10619494": { "compartment": "compartment_876", "id": "reaction_10619494", "reactome": "R-DDI-8855130", "name": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619484" ], "products": [ "species_10619492" ], "modifiers": [], "additional_components": [ "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403", "Q54H39", "DDB_G0289721", "Q54X82", "DDB_G0279141", "Q86KI1", "DDB_G0273439", "P54672", "DDB_G0277139", "P54672", "DDB_G0277139", "Q54H39", "DDB_G0289721", "Q86KI1", "DDB_G0273439", "Q54X82", "DDB_G0279141", "P25870", "DDB_G0277221", "Q8MN58", "DDB_G0277403" ] }, "reaction_10607943": { "compartment": "compartment_70101", "id": "reaction_10607943", "reactome": "R-DDI-5682101", "name": "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10607908" ], "products": [ "species_29370", "species_10607940" ], "modifiers": [ [ "species_10582991", "catalyst" ] ], "additional_components": [ "Q8T6J5", "DDB_G0267438", "Q54BT5", "DDB_G0293436", "Q555Z5", "DDB_G0274121", "Q55BC0", "DDB_G0271138", "Q8T5Z7", "DDB_G0291994", "Q8T6J1", "DDB_G0291245", "Q8T6J2", "DDB_G0274119", "Q55BC0", "DDB_G0271138", "Q8T6J5", "DDB_G0267438", "Q8T5Z7", "DDB_G0291994", "Q54BT5", "DDB_G0293436", "Q8T6J1", "DDB_G0291245", "Q555Z5", "DDB_G0274121", "Q8T6J2", "DDB_G0274119", "P34099", "DDB_G0283907", "P34100", "DDB_G0277145", "P34103", "DDB_G0284029" ] }, "reaction_10607945": { "compartment": "compartment_12045", "id": "reaction_10607945", "reactome": "R-DDI-5682103", "name": "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10607890" ], "products": [ "species_10607908" ], "modifiers": [], "additional_components": [ "Q555Z5", "DDB_G0274121", "Q8T6J1", "DDB_G0291245", "Q55BC0", "DDB_G0271138", "Q8T6J2", "DDB_G0274119", "Q54BT5", "DDB_G0293436", "Q8T5Z7", "DDB_G0291994", "Q8T6J5", "DDB_G0267438", "Q8T6J5", "DDB_G0267438", "Q54BT5", "DDB_G0293436", "Q555Z5", "DDB_G0274121", "Q55BC0", "DDB_G0271138", "Q8T5Z7", "DDB_G0291994", "Q8T6J1", "DDB_G0291245", "Q8T6J2", "DDB_G0274119" ] }, "reaction_10620000": { "compartment": "compartment_70616", "id": "reaction_10620000", "reactome": "R-DDI-8867344", "name": "OMA1 hydrolyses OPA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619980", "species_113521" ], "products": [ "species_10619992", "species_10619986" ], "modifiers": [ [ "species_10619997", "catalyst" ] ], "additional_components": [ "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "Q9U1M9", "DDB_G0277851", "Q94464", "DDB_G0277849", "DDB_G0289335" ] }, "reaction_10604720": { "compartment": "compartment_70101", "id": "reaction_10604720", "reactome": "R-DDI-5213464", "name": "RIPK1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10604713" ], "products": [ "species_10604715", "species_29370" ], "modifiers": [ [ "species_10604713", "catalyst" ], [ "species_10604718", "inhibitor" ] ], "additional_components": [ "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417" ] }, "reaction_10604723": { "compartment": "compartment_70101", "id": "reaction_10604723", "reactome": "R-DDI-5213466", "name": "RIPK3 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604715", "species_113592" ], "products": [ "species_10602348", "species_29370" ], "modifiers": [ [ "species_10604713", "catalyst" ], [ "species_10604718", "inhibitor" ] ], "additional_components": [ "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417" ] }, "reaction_10604757": { "compartment": "compartment_70101", "id": "reaction_10604757", "reactome": "R-DDI-5218891", "name": "RIPK1:RIPK3 oligomer binds MLKL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602350", "species_10604753" ], "products": [ "species_10604755" ], "modifiers": [], "additional_components": [ "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "DDB_G0281557", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417" ] }, "reaction_10604759": { "compartment": "compartment_70101", "id": "reaction_10604759", "reactome": "R-DDI-5218905", "name": "RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602348" ], "products": [ "species_10602350" ], "modifiers": [], "additional_components": [ "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417" ] }, "reaction_10605782": { "compartment": "compartment_876", "id": "reaction_10605782", "reactome": "R-DDI-5620975", "name": "MLKL binds PIPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5620974", "species_10602358" ], "products": [ "species_10605771" ], "modifiers": [ [ "species_10605780", "inhibitor" ] ], "additional_components": [ "species_179838", "species_1806180", "species_179856", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "species_179838", "species_1806180", "species_179856", "Q8T7K0", "DDB_G0275451", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417" ] }, "reaction_10604764": { "compartment": "compartment_70101", "id": "reaction_10604764", "reactome": "R-DDI-5218906", "name": "RIPK3 phosphorylates MLKL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10604755" ], "products": [ "species_29370", "species_10604761" ], "modifiers": [ [ "species_10604755", "catalyst" ] ], "additional_components": [ "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417", "Q54TM7", "DDB_G0281557", "Q54XX5", "DDB_G0278535", "Q54WS5", "DDB_G0279417" ] }, "reaction_10600860": { "compartment": "compartment_70101", "id": "reaction_10600860", "reactome": "R-DDI-2317332", "name": "PIP3 recruits AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10590487" ], "products": [ "species_10587009" ], "modifiers": [], "additional_components": [ "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795", "species_179838", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795" ] }, "reaction_10625796": { "compartment": "compartment_17951", "id": "reaction_10625796", "reactome": "R-DDI-9033520", "name": "TYSND1 cleaves TYSND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_10625726" ], "products": [ "species_10625791", "species_10625793" ], "modifiers": [ [ "species_10625726", "catalyst" ] ], "additional_components": [ "DDB_G0279049", "DDB_G0279049", "DDB_G0279049", "DDB_G0279049" ] }, "reaction_10589960": { "compartment": "compartment_70101", "id": "reaction_10589960", "reactome": "R-DDI-380930", "name": "Phosphorylated AMPK binds AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587326", "species_76577" ], "products": [ "species_10589958" ], "modifiers": [], "additional_components": [ "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643" ] }, "reaction_10592925": { "compartment": "compartment_876", "id": "reaction_10592925", "reactome": "R-DDI-447074", "name": "AMPK phosphorylates Raptor in the mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10584242" ], "products": [ "species_29370", "species_10584309" ], "modifiers": [ [ "species_10589958", "catalyst" ] ], "additional_components": [ "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "species_76577", "Q54UG7", "DDB_G0281089", "Q8T277", "DDB_G0272542", "Q54YF2", "DDB_G0277905", "Q54MV2", "DDB_G0285643" ] }, "reaction_10606321": { "compartment": "compartment_70101", "id": "reaction_10606321", "reactome": "R-DDI-5653957", "name": "Rag dimer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584219", "species_10584232" ], "products": [ "species_10584234" ], "modifiers": [], "additional_components": [ "Q54IK1", "DDB_G0288701", "species_29438", "Q54PK6", "DDB_G0284495", "species_29420", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438" ] }, "reaction_10623826": { "compartment": "compartment_70101", "id": "reaction_10623826", "reactome": "R-DDI-8952726", "name": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428011" ], "products": [ "species_29468" ], "modifiers": [ [ "species_10584238", "catalyst" ] ], "additional_components": [ "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567" ] }, "reaction_10584160": { "compartment": "compartment_17938", "id": "reaction_10584160", "reactome": "R-DDI-165195", "name": "GTP loading by Rheb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10584156" ], "products": [ "species_10584158", "species_29420" ], "modifiers": [], "additional_components": [ "Q54DD9", "DDB_G0292318", "species_29420", "Q54DD9", "DDB_G0292318", "species_29438" ] }, "reaction_10606323": { "compartment": "compartment_17938", "id": "reaction_10606323", "reactome": "R-DDI-5653968", "name": "Ragulator:Rag dimers:SLC38A9 bind mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584238", "species_10584177" ], "products": [ "species_10584240" ], "modifiers": [], "additional_components": [ "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567" ] }, "reaction_10589778": { "compartment": "compartment_17938", "id": "reaction_10589778", "reactome": "R-DDI-377186", "name": "Activated Akt1 phosphorylates AKT1S1 (PRAS40)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10584263" ], "products": [ "species_10584255", "species_29370" ], "modifiers": [ [ "species_10587569", "catalyst" ] ], "additional_components": [ "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "P54644", "DDB_G0268620", "Q54IF2", "DDB_G0288795" ] }, "reaction_10606325": { "compartment": "compartment_70101", "id": "reaction_10606325", "reactome": "R-DDI-5653974", "name": "Ragulator binds Rag dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584206", "species_10584234" ], "products": [ "species_10584236" ], "modifiers": [], "additional_components": [ "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567" ] }, "reaction_10584244": { "compartment": "compartment_70101", "id": "reaction_10584244", "reactome": "R-DDI-165680", "name": "Formation of active mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584158", "species_10584240" ], "products": [ "species_10584242" ], "modifiers": [], "additional_components": [ "Q54DD9", "DDB_G0292318", "species_29438", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318" ] }, "reaction_10584272": { "compartment": "compartment_17938", "id": "reaction_10584272", "reactome": "R-DDI-165692", "name": "Phosphorylation of 4E-BP1 by activated mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580061", "species_113592" ], "products": [ "species_10584250", "species_29370" ], "modifiers": [ [ "species_10584242", "catalyst" ], [ "species_10584259", "catalyst" ], [ "species_10584263", "inhibitor" ], [ "species_10584270", "inhibitor" ] ], "additional_components": [ "Q55FE0", "DDB_G0268574", "Q54DU8", "DDB_G0291990", "Q55FE0", "DDB_G0268574", "Q54DU8", "DDB_G0291990", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54UR2", "DDB_G0280877" ] }, "reaction_10584339": { "compartment": "compartment_70101", "id": "reaction_10584339", "reactome": "R-DDI-165766", "name": "Phosphorylation and activation of eIF4G by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10580029", "species_113592" ], "products": [ "species_29370", "species_10584337" ], "modifiers": [ [ "species_10584299", "catalyst" ] ], "additional_components": [ "DDB_G0275395", "DDB_G0275395", "P34102", "DDB_G0286125", "Q8MYF1", "DDB_G0277449" ] }, "reaction_10627344": { "compartment": "compartment_70101", "id": "reaction_10627344", "reactome": "R-DDI-9679044", "name": "FKBP1A binds sirolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584268", "species_9678687" ], "products": [ "species_10584270" ], "modifiers": [], "additional_components": [ "DDB_G0280877", "Q54UR2", "DDB_G0280877" ] }, "reaction_10584322": { "compartment": "compartment_70101", "id": "reaction_10584322", "reactome": "R-DDI-165726", "name": "Phosphorylation of Ribosomal protein S6 by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10579877" ], "products": [ "species_10584319", "species_29370" ], "modifiers": [ [ "species_10584299", "catalyst" ] ], "additional_components": [ "DDB_G0280823", "DDB_G0280823", "P34102", "DDB_G0286125", "Q8MYF1", "DDB_G0277449" ] }, "reaction_10584277": { "compartment": "compartment_70101", "id": "reaction_10584277", "reactome": "R-DDI-165708", "name": "Dissociation of phosphorylated 4EBP1 from eIF4E", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584250" ], "products": [ "species_10584248", "species_10580024" ], "modifiers": [], "additional_components": [ "Q55FE0", "DDB_G0268574", "Q54DU8", "DDB_G0291990", "DDB_G0291990", "DDB_G0268574" ] }, "reaction_10584311": { "compartment": "compartment_17938", "id": "reaction_10584311", "reactome": "R-DDI-165718", "name": "mTORC1 phosphorylation of RPS6KB1 (S6K)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10584289" ], "products": [ "species_10584299", "species_29370" ], "modifiers": [ [ "species_10584242", "catalyst" ], [ "species_10584259", "catalyst" ], [ "species_10584309", "inhibitor" ], [ "species_10584270", "inhibitor" ] ], "additional_components": [ "P34102", "DDB_G0286125", "Q8MYF1", "DDB_G0277449", "P34102", "DDB_G0286125", "Q8MYF1", "DDB_G0277449", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54UR2", "DDB_G0280877" ] }, "reaction_10584344": { "compartment": "compartment_70101", "id": "reaction_10584344", "reactome": "R-DDI-165777", "name": "Phosphorylation and activation of eIF4B by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10580036" ], "products": [ "species_29370", "species_10584342" ], "modifiers": [ [ "species_10584299", "catalyst" ] ], "additional_components": [ "DDB_G0275459", "DDB_G0275459", "P34102", "DDB_G0286125", "Q8MYF1", "DDB_G0277449" ] }, "reaction_10584332": { "compartment": "compartment_70101", "id": "reaction_10584332", "reactome": "R-DDI-165758", "name": "Phosphorylation and inactivation of eEF2K by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10584327" ], "products": [ "species_10584330", "species_29370" ], "modifiers": [ [ "species_10584299", "catalyst" ] ], "additional_components": [ "DDB_G0282489", "DDB_G0282489", "P34102", "DDB_G0286125", "Q8MYF1", "DDB_G0277449" ] }, "reaction_10606859": { "compartment": "compartment_17938", "id": "reaction_10606859", "reactome": "R-DDI-5672828", "name": "mTORC1 phosphorylates AKT1S1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10584259" ], "products": [ "species_29370", "species_10606856" ], "modifiers": [ [ "species_10584259", "catalyst" ] ], "additional_components": [ "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318", "Q54D08", "DDB_G0292592", "Q86C65", "DDB_G0281569", "Q55BR7", "DDB_G0270398", "Q54PK6", "DDB_G0284495", "species_29420", "Q54IK1", "DDB_G0288701", "species_29438", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567", "Q54DD9", "DDB_G0292318" ] }, "reaction_10606319": { "compartment": "compartment_17938", "id": "reaction_10606319", "reactome": "R-DDI-5653936", "name": "Formation of Ragulator complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584204", "species_10584189", "species_10584184", "species_10584199", "species_10584194" ], "products": [ "species_10584206" ], "modifiers": [], "additional_components": [ "DDB_G0283567", "DDB_G0291091", "DDB_G0292160", "DDB_G0291948", "DDB_G0274833", "Q86J23", "DDB_G0274833", "Q54DY3", "DDB_G0291948", "Q1ZXA8", "DDB_G0292160", "Q54F59", "DDB_G0291091", "Q54QW5", "DDB_G0283567" ] }, "reaction_10605537": { "compartment": "compartment_70101", "id": "reaction_10605537", "reactome": "R-DDI-5615668", "name": "AKR1C3 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_975622", "species_29364" ], "products": [ "species_29366", "species_975599" ], "modifiers": [ [ "species_10586594", "catalyst" ] ], "additional_components": [ "Q6IMN8", "DDB_G0293850", "Q54NZ7", "DDB_G0285053", "Q55FL2", "DDB_G0268562", "Q55FL3", "DDB_G0268058" ] }, "reaction_10605363": { "compartment": "compartment_70101", "id": "reaction_10605363", "reactome": "R-DDI-5362564", "name": "ADH1A,1C,4 oxidise atROL to atRAL in vitro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975599", "species_29360" ], "products": [ "species_70106", "species_975622", "species_73473" ], "modifiers": [ [ "species_10605360", "catalyst" ] ], "additional_components": [ "species_29426", "Q54TC2", "DDB_G0281865" ] }, "reaction_10611912": { "compartment": "compartment_70101", "id": "reaction_10611912", "reactome": "R-DDI-5696101", "name": "ALDH8A1 oxidises 9cRAL to 9cRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5362565", "species_29360" ], "products": [ "species_70106", "species_5362520", "species_73473" ], "modifiers": [ [ "species_10611909", "catalyst" ] ], "additional_components": [ "DDB_G0283943" ] }, "reaction_10605371": { "compartment": "compartment_70101", "id": "reaction_10605371", "reactome": "R-DDI-5419165", "name": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_975622", "species_29364" ], "products": [ "species_29366", "species_975599" ], "modifiers": [ [ "species_10605368", "catalyst" ] ], "additional_components": [ "DDB_G0293604" ] }, "reaction_10605791": { "compartment": "compartment_70616", "id": "reaction_10605791", "reactome": "R-DDI-5623643", "name": "RDH13 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5623644", "species_5623648", "species_163953" ], "products": [ "species_5623650", "species_5623649" ], "modifiers": [ [ "species_10605788", "catalyst" ] ], "additional_components": [ "DDB_G0286575" ] }, "reaction_10605358": { "compartment": "compartment_70101", "id": "reaction_10605358", "reactome": "R-DDI-5362522", "name": "ALDHs oxidise atRAL to atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_975622", "species_29360" ], "products": [ "species_70106", "species_5334816", "species_73473" ], "modifiers": [ [ "species_10605355", "catalyst" ] ], "additional_components": [ "Q54IU0", "DDB_G0288521" ] }, "reaction_10624618": { "compartment": "compartment_7660", "id": "reaction_10624618", "reactome": "R-DDI-9012319", "name": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10624613" ], "products": [ "species_113582", "species_10624615" ], "modifiers": [ [ "species_10624613", "catalyst" ] ], "additional_components": [ "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "species_1254400", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "species_1254400", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "P35084", "DDB_G0279193", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54LJ0", "DDB_G0286617", "Q556Z2", "DDB_G0273207", "species_1254400", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54FA8", "DDB_G0291037", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54P04", "DDB_G0284891", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q86JJ5", "DDB_G0277677", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131" ] }, "reaction_10623125": { "compartment": "compartment_7660", "id": "reaction_10623125", "reactome": "R-DDI-8939204", "name": "ESTG binds ESR1:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623113", "species_1254400" ], "products": [ "species_10623115" ], "modifiers": [], "additional_components": [ "Q54WQ9", "DDB_G0279491", "P54651", "DDB_G0267400", "species_113592", "Q55FM3", "DDB_G0268042", "species_1254400", "Q54WQ9", "DDB_G0279491", "P54651", "DDB_G0267400", "species_113592", "Q55FM3", "DDB_G0268042" ] }, "reaction_10627482": { "compartment": "compartment_7660", "id": "reaction_10627482", "reactome": "R-DDI-9709547", "name": "ESTG binds ESR2:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623119", "species_1254400" ], "products": [ "species_10623121" ], "modifiers": [], "additional_components": [ "Q54WQ9", "DDB_G0279491", "P54651", "DDB_G0267400", "species_113592", "Q55FM3", "DDB_G0268042", "species_1254400", "Q54WQ9", "DDB_G0279491", "P54651", "DDB_G0267400", "species_113592", "Q55FM3", "DDB_G0268042" ] }, "reaction_10598291": { "compartment": "compartment_70101", "id": "reaction_10598291", "reactome": "R-DDI-1504190", "name": "DVL is ubiquitinated by CUL3:KLHL12:RBX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598284", "species_10577037" ], "products": [ "species_10598288" ], "modifiers": [ [ "species_10598284", "catalyst" ] ], "additional_components": [ "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903", "Q55BF8", "DDB_G0271372", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903", "Q55BF8", "DDB_G0271372", "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903", "Q55BF8", "DDB_G0271372" ] }, "reaction_10598293": { "compartment": "compartment_70101", "id": "reaction_10598293", "reactome": "R-DDI-1504193", "name": "Ubiquitinated DVL is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10598288" ], "products": [ "species_10577037", "species_10598280" ], "modifiers": [ [ "species_10577240", "catalyst" ] ], "additional_components": [ "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903", "Q55BF8", "DDB_G0271372", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54K33", "DDB_G0287629", "Q54NZ5", "DDB_G0284903", "Q55BF8", "DDB_G0271372", "Q55GJ6", "DDB_G0267390", "Q1ZXD3", "DDB_G0288621", "Q54BC8", "DDB_G0293784", "Q54DM7", "DDB_G0292122", "Q54BC6", "DDB_G0293752", "Q54QR2", "DDB_G0283679", "Q27562", "DDB_G0282363", "Q54NQ0", "DDB_G0285105", "P34120", "DDB_G0272831", "Q86IJ1", "DDB_G0272566", "Q54DB2", "DDB_G0292398", "Q54UJ0", "DDB_G0281051", "Q556Q0", "DDB_G0273163", "Q54S82", "DDB_G0282617", "Q54UB5", "DDB_G0281315", "Q55D66", "DDB_G0269772", "Q967U1", "DDB_G0285099", "Q54HW1", "DDB_G0289189", "Q55DY7", "DDB_G0269472", "Q54JM5", "DDB_G0287953", "Q54PJ1", "DDB_G0284517", "Q552Y8", "DDB_G0275753", "Q86A21", "DDB_G0272969", "P02889", "DDB_G0272564", "P34124", "DDB_G0292382", "P34123", "DDB_G0289003", "Q54WI8", "DDB_G0279633", "Q54XM7", "DDB_G0278847", "Q55C75", "DDB_G0270188", "Q54PN7", "DDB_G0284415", "Q55G04", "DDB_G0268538", "Q86JA1", "DDB_G0276917", "Q559F4", "DDB_G0272951", "P34119", "DDB_G0280969", "Q553E0", "DDB_G0275775", "Q55BV5", "DDB_G0270784", "Q27563", "DDB_G0267408" ] }, "reaction_10602277": { "compartment": "compartment_20699", "id": "reaction_10602277", "reactome": "R-DDI-3247836", "name": "Retromer recycles WLS to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602271" ], "products": [ "species_10602275" ], "modifiers": [], "additional_components": [ "Q54C24", "DDB_G0293218", "Q55CA0", "DDB_G0269168", "Q54IF7", "DDB_G0288787", "Q54UN7", "DDB_G0280921", "Q54C24", "DDB_G0293218", "Q55CA0", "DDB_G0269168", "Q54IF7", "DDB_G0288787", "Q54UN7", "DDB_G0280921" ] }, "reaction_10600819": { "compartment": "compartment_70101", "id": "reaction_10600819", "reactome": "R-DDI-2219524", "name": "PDPK1 binds PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587607", "species_179856" ], "products": [ "species_10600817" ], "modifiers": [], "additional_components": [ "DDB_G0281471", "species_179856", "Q54TW2", "DDB_G0281471" ] }, "reaction_10596961": { "compartment": "compartment_70101", "id": "reaction_10596961", "reactome": "R-DDI-1011598", "name": "DOCKs bind to RhoGEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596957", "species_10590248" ], "products": [ "species_10596959" ], "modifiers": [], "additional_components": [ "Q54CA8", "DDB_G0293084", "Q554I8", "DDB_G0293084", "Q55EI2", "DDB_G0293084", "Q86I66", "DDB_G0293084", "Q54PB7", "DDB_G0292004", "Q55BQ8", "DDB_G0292004", "Q54DS6", "DDB_G0291974", "Q54DW1", "DDB_G0292004", "DDB_G0277869", "P34144", "DDB_G0277869", "Q54CA8", "DDB_G0293084", "Q554I8", "DDB_G0293084", "Q55EI2", "DDB_G0293084", "Q86I66", "DDB_G0293084", "Q54PB7", "DDB_G0292004", "Q55BQ8", "DDB_G0292004", "Q54DS6", "DDB_G0291974", "Q54DW1", "DDB_G0292004" ] }, "reaction_10596720": { "compartment": "compartment_70101", "id": "reaction_10596720", "reactome": "R-DDI-984689", "name": "Kinesin-7 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596682" ], "products": [ "species_10596684" ], "modifiers": [], "additional_components": [ "DDB_G0285101", "Q54NP8", "DDB_G0285101" ] }, "reaction_10596718": { "compartment": "compartment_70101", "id": "reaction_10596718", "reactome": "R-DDI-984606", "name": "Kinesin-5 is a homotetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596668" ], "products": [ "species_10596670" ], "modifiers": [], "additional_components": [ "DDB_G0288361", "Q6RZZ9", "DDB_G0288361" ] }, "reaction_10596740": { "compartment": "compartment_7660", "id": "reaction_10596740", "reactome": "R-DDI-994106", "name": "HP1 alpha binds Histone H3K9(me)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10596728", "species_10596736" ], "products": [ "species_10596738" ], "modifiers": [], "additional_components": [ "Q54RN0", "DDB_G0283023", "Q54RQ4", "DDB_G0283023", "Q55C69", "DDB_G0270198", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q54RN0", "DDB_G0283023", "Q54RQ4", "DDB_G0283023", "Q55C69", "DDB_G0270198" ] }, "reaction_10596807": { "compartment": "compartment_70101", "id": "reaction_10596807", "reactome": "R-DDI-994148", "name": "LRRC16A binds F-actin capping protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594244", "species_10596803" ], "products": [ "species_10596805" ], "modifiers": [], "additional_components": [ "P13021", "DDB_G0267374", "P13022", "DDB_G0272104", "Q95VZ3", "DDB_G0292386", "Q54LE3", "DDB_G0293920", "Q54SR9", "DDB_G0293920", "Q54B43", "DDB_G0293920", "Q54YK2", "DDB_G0293920", "Q54B76", "DDB_G0293920", "Q54MF0", "DDB_G0293920", "Q54NS2", "DDB_G0293920", "Q7KWW4", "DDB_G0293920", "Q54G18", "DDB_G0290439", "Q95VZ3", "DDB_G0292386", "Q54LE3", "DDB_G0293920", "Q54SR9", "DDB_G0293920", "Q54B43", "DDB_G0293920", "Q54YK2", "DDB_G0293920", "Q54B76", "DDB_G0293920", "Q54MF0", "DDB_G0293920", "Q54NS2", "DDB_G0293920", "Q7KWW4", "DDB_G0293920", "Q54G18", "DDB_G0290439", "P13021", "DDB_G0267374", "P13022", "DDB_G0272104" ] }, "reaction_10600822": { "compartment": "compartment_70101", "id": "reaction_10600822", "reactome": "R-DDI-2267372", "name": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994123" ], "products": [ "species_994146", "species_29370" ], "modifiers": [ [ "species_10596745", "catalyst" ] ], "additional_components": [ "DDB_G0269746" ] }, "reaction_10594246": { "compartment": "compartment_70101", "id": "reaction_10594246", "reactome": "R-DDI-879459", "name": "F-actin capping protein is a heterodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594237", "species_10594242" ], "products": [ "species_10594244" ], "modifiers": [], "additional_components": [ "DDB_G0272104", "DDB_G0267374", "P13021", "DDB_G0267374", "P13022", "DDB_G0272104" ] }, "reaction_10619768": { "compartment": "compartment_70101", "id": "reaction_10619768", "reactome": "R-DDI-8865107", "name": "MICAL1 produces NADP+, H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29364" ], "products": [ "species_29366", "species_29408" ], "modifiers": [ [ "species_10619765", "catalyst" ] ], "additional_components": [ "Q54FV6", "DDB_G0293708", "Q54BL7", "DDB_G0293708", "species_113596" ] }, "reaction_10596826": { "compartment": "compartment_5460", "id": "reaction_10596826", "reactome": "R-DDI-1008248", "name": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159448", "species_113573" ], "products": [ "species_113581", "species_113525" ], "modifiers": [ [ "species_10596823", "catalyst" ] ], "additional_components": [ "DDB_G0292730" ] }, "reaction_10596748": { "compartment": "compartment_70101", "id": "reaction_10596748", "reactome": "R-DDI-994137", "name": "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_994149", "species_113592" ], "products": [ "species_29370", "species_994141" ], "modifiers": [ [ "species_10596745", "catalyst" ] ], "additional_components": [ "DDB_G0269746" ] }, "reaction_10596751": { "compartment": "compartment_70101", "id": "reaction_10596751", "reactome": "R-DDI-994140", "name": "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994123" ], "products": [ "species_29370", "species_994170" ], "modifiers": [ [ "species_10596745", "catalyst" ] ], "additional_components": [ "DDB_G0269746" ] }, "reaction_10587611": { "compartment": "compartment_70101", "id": "reaction_10587611", "reactome": "R-DDI-202164", "name": "Translocation of PDK1 to Plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10587607", "species_202277" ], "products": [ "species_10587609" ], "modifiers": [], "additional_components": [ "DDB_G0281471", "species_1806238", "species_179838", "species_1806238", "species_179838", "Q54TW2", "DDB_G0281471" ] }, "reaction_10626100": { "compartment": "compartment_70101", "id": "reaction_10626100", "reactome": "R-DDI-9609921", "name": "SGTA binds Tail-anchored protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626061", "species_10626096" ], "products": [ "species_10626098" ], "modifiers": [], "additional_components": [ "Q54VG4", "DDB_G0280345", "Q553P6", "DDB_G0275381", "Q86L22", "DDB_G0277079", "Q54XT7", "DDB_G0278753", "Q54ZH1", "DDB_G0277565", "Q54HM5", "DDB_G0289379", "Q54DG1", "DDB_G0292270", "Q54YR4", "DDB_G0278117", "Q54LP7", "DDB_G0286511", "Q54XS7", "DDB_G0278773", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54JV6", "DDB_G0287777", "Q553P6", "DDB_G0275381", "Q86L22", "DDB_G0277079", "Q54XT7", "DDB_G0278753", "Q54ZH1", "DDB_G0277565", "Q54HM5", "DDB_G0289379", "Q54DG1", "DDB_G0292270", "Q54YR4", "DDB_G0278117", "Q54LP7", "DDB_G0286511", "Q54XS7", "DDB_G0278773", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54JV6", "DDB_G0287777", "Q54VG4", "DDB_G0280345" ] }, "reaction_10626164": { "compartment": "compartment_70101", "id": "reaction_10626164", "reactome": "R-DDI-9617595", "name": "SGTA binds mislocalized membrane protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10626061", "species_10626092" ], "products": [ "species_10626162" ], "modifiers": [], "additional_components": [ "Q54VG4", "DDB_G0280345", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q54VG4", "DDB_G0280345" ] }, "reaction_10625730": { "compartment": "compartment_17947", "id": "reaction_10625730", "reactome": "R-DDI-9033235", "name": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625710" ], "products": [ "species_10623900", "species_10625728" ], "modifiers": [], "additional_components": [ "Q556W1", "DDB_G0273291", "Q54E41", "DDB_G0291814", "Q75JR2", "DDB_G0272210", "Q54XC3", "DDB_G0279049", "Q54US8", "DDB_G0280851", "Q54GT6", "DDB_G0289923", "Q54QI7", "DDB_G0283813", "Q54GK8", "DDB_G0290089", "Q54GQ6", "DDB_G0289993", "Q54XZ0", "DDB_G0277911", "Q7KWR0", "DDB_G0276281", "Q8MMS1", "DDB_G0277477", "Q54T91", "DDB_G0281917", "Q5FXM5", "DDB_G0270658", "Q54SS0", "DDB_G0282261", "Q54GC2", "DDB_G0290277", "Q54JQ2", "DDB_G0287851", "Q55CT1", "DDB_G0269912", "O77229", "DDB_G0274595", "Q54FR4", "DDB_G0290631", "Q54DA9", "DDB_G0292402", "Q54MD1", "DDB_G0286033", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54MD1", "DDB_G0286033", "Q54GT6", "DDB_G0289923", "Q5FXM5", "DDB_G0270658", "Q54GQ6", "DDB_G0289993", "Q54DA9", "DDB_G0292402", "Q8MMS1", "DDB_G0277477", "Q54E41", "DDB_G0291814", "Q54GC2", "DDB_G0290277", "Q75JR2", "DDB_G0272210", "Q54US8", "DDB_G0280851", "Q54T91", "DDB_G0281917", "Q54SS0", "DDB_G0282261", "O77229", "DDB_G0274595", "Q7KWR0", "DDB_G0276281", "Q54QI7", "DDB_G0283813", "Q55CT1", "DDB_G0269912", "Q556W1", "DDB_G0273291", "Q54JQ2", "DDB_G0287851", "Q54XZ0", "DDB_G0277911", "Q54XC3", "DDB_G0279049", "Q54GK8", "DDB_G0290089", "Q54FR4", "DDB_G0290631" ] }, "reaction_10625798": { "compartment": "compartment_17947", "id": "reaction_10625798", "reactome": "R-DDI-9033527", "name": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10623902", "species_10625736" ], "products": [ "species_10625738" ], "modifiers": [], "additional_components": [ "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54WA3", "DDB_G0279801", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54MD1", "DDB_G0286033", "Q54WA3", "DDB_G0279801", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54MD1", "DDB_G0286033", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765" ] }, "reaction_10625732": { "compartment": "compartment_17947", "id": "reaction_10625732", "reactome": "R-DDI-9033236", "name": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625708", "species_10625706" ], "products": [ "species_10625710" ], "modifiers": [], "additional_components": [ "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q556W1", "DDB_G0273291", "Q54E41", "DDB_G0291814", "Q75JR2", "DDB_G0272210", "Q54XC3", "DDB_G0279049", "Q54US8", "DDB_G0280851", "Q54GT6", "DDB_G0289923", "Q54QI7", "DDB_G0283813", "Q54GK8", "DDB_G0290089", "Q54GQ6", "DDB_G0289993", "Q54XZ0", "DDB_G0277911", "Q7KWR0", "DDB_G0276281", "Q8MMS1", "DDB_G0277477", "Q54T91", "DDB_G0281917", "Q5FXM5", "DDB_G0270658", "Q54SS0", "DDB_G0282261", "Q54GC2", "DDB_G0290277", "Q54JQ2", "DDB_G0287851", "Q55CT1", "DDB_G0269912", "O77229", "DDB_G0274595", "Q54FR4", "DDB_G0290631", "Q54DA9", "DDB_G0292402", "Q54MD1", "DDB_G0286033", "Q556W1", "DDB_G0273291", "Q54E41", "DDB_G0291814", "Q75JR2", "DDB_G0272210", "Q54XC3", "DDB_G0279049", "Q54US8", "DDB_G0280851", "Q54GT6", "DDB_G0289923", "Q54QI7", "DDB_G0283813", "Q54GK8", "DDB_G0290089", "Q54GQ6", "DDB_G0289993", "Q54XZ0", "DDB_G0277911", "Q7KWR0", "DDB_G0276281", "Q8MMS1", "DDB_G0277477", "Q54T91", "DDB_G0281917", "Q5FXM5", "DDB_G0270658", "Q54SS0", "DDB_G0282261", "Q54GC2", "DDB_G0290277", "Q54JQ2", "DDB_G0287851", "Q55CT1", "DDB_G0269912", "O77229", "DDB_G0274595", "Q54FR4", "DDB_G0290631", "Q54DA9", "DDB_G0292402", "Q54MD1", "DDB_G0286033", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523" ] }, "reaction_10625643": { "compartment": "compartment_70101", "id": "reaction_10625643", "reactome": "R-DDI-9033232", "name": "PEX7 binds cargo proteins containing PTS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625628", "species_10625639" ], "products": [ "species_10625641" ], "modifiers": [], "additional_components": [ "DDB_G0279801", "O96759", "DDB_G0286183", "Q54SF6", "DDB_G0282495", "Q86IY4", "DDB_G0274339", "O96759", "DDB_G0286183", "Q54SF6", "DDB_G0282495", "Q86IY4", "DDB_G0274339", "Q54WA3", "DDB_G0279801" ] }, "reaction_10625752": { "compartment": "compartment_70101", "id": "reaction_10625752", "reactome": "R-DDI-9033491", "name": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10625749" ], "products": [ "species_10619197", "species_10577037", "species_10625704" ], "modifiers": [ [ "species_10625749", "catalyst" ] ], "additional_components": [ "Q54MD1", "DDB_G0286033", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q553T4", "DDB_G0275415", "DDB_G0275415", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0286033", "Q54MD1", "DDB_G0286033", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q553T4", "DDB_G0275415" ] }, "reaction_10625743": { "compartment": "compartment_17947", "id": "reaction_10625743", "reactome": "R-DDI-9033485", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625738" ], "products": [ "species_10625740", "species_10577361" ], "modifiers": [ [ "species_10625738", "catalyst" ] ], "additional_components": [ "Q54WA3", "DDB_G0279801", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54MD1", "DDB_G0286033", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54WA3", "DDB_G0279801", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54MD1", "DDB_G0286033", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54IK3", "DDB_G0288697", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54WA3", "DDB_G0279801", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54MD1", "DDB_G0286033", "Q54J12", "DDB_G0288697", "Q94490", "DDB_G0284865", "Q54IK3", "DDB_G0288697", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765" ] }, "reaction_10625775": { "compartment": "compartment_70101", "id": "reaction_10625775", "reactome": "R-DDI-9033509", "name": "USP9X binds Ub:PEX5L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619197", "species_10625747" ], "products": [ "species_10625749" ], "modifiers": [], "additional_components": [ "DDB_G0275415", "Q54MD1", "DDB_G0286033", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q54MD1", "DDB_G0286033", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "Q553T4", "DDB_G0275415" ] }, "reaction_10625789": { "compartment": "compartment_17947", "id": "reaction_10625789", "reactome": "R-DDI-9033514", "name": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625779" ], "products": [ "species_10625736", "species_10625787" ], "modifiers": [], "additional_components": [ "Q54MD1", "DDB_G0286033", "O96759", "DDB_G0286183", "Q54SF6", "DDB_G0282495", "Q86IY4", "DDB_G0274339", "Q54WA3", "DDB_G0279801", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54WA3", "DDB_G0279801", "Q54CL3", "DDB_G0292870", "Q54C55", "DDB_G0293264", "Q54S31", "DDB_G0282693", "Q54N40", "DDB_G0285523", "Q54MD1", "DDB_G0286033", "O96759", "DDB_G0286183", "Q86IY4", "DDB_G0274339", "Q54SF6", "DDB_G0282495" ] }, "reaction_10625927": { "compartment": "compartment_17947", "id": "reaction_10625927", "reactome": "R-DDI-9603775", "name": "PEX3:PEX19:class I PMP dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625899" ], "products": [ "species_10625925", "species_10590211", "species_10590227" ], "modifiers": [], "additional_components": [ "Q54U86", "DDB_G0281213", "Q555I0", "DDB_G0274873", "Q54ZX5", "DDB_G0290631", "Q54FR4", "DDB_G0290631", "Q54GD8", "DDB_G0290631", "Q54XX9", "DDB_G0290631", "Q8T8P3", "DDB_G0293194", "Q54N40", "DDB_G0285523", "Q55FL0", "DDB_G0268564", "Q54VX0", "DDB_G0280367", "Q86AC7", "DDB_G0276913", "Q54H86", "DDB_G0289623", "Q54DG1", "DDB_G0292270", "Q54C55", "DDB_G0293264", "Q54CL3", "DDB_G0292870", "Q76P23", "DDB_G0272346", "Q1ZXK7", "DDB_G0276169", "Q550G0", "DDB_G0277113", "Q86AC7", "DDB_G0276913", "Q54H86", "DDB_G0289623", "Q8T8P3", "DDB_G0293194", "Q54CL3", "DDB_G0292870", "Q550G0", "DDB_G0277113", "Q54N40", "DDB_G0285523", "Q54C55", "DDB_G0293264", "Q54DG1", "DDB_G0292270", "Q54FR4", "DDB_G0290631", "Q54XX9", "DDB_G0290631", "Q54GD8", "DDB_G0290631", "Q54ZX5", "DDB_G0290631", "Q76P23", "DDB_G0272346", "Q54VX0", "DDB_G0280367", "Q1ZXK7", "DDB_G0276169", "Q55FL0", "DDB_G0268564", "DDB_G0281213", "DDB_G0274873" ] }, "reaction_10625931": { "compartment": "compartment_70101", "id": "reaction_10625931", "reactome": "R-DDI-9603804", "name": "PEX19 binds class I peroxisomal membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625895", "species_10590227" ], "products": [ "species_10625897" ], "modifiers": [], "additional_components": [ "Q54ZX5", "DDB_G0290631", "Q54FR4", "DDB_G0290631", "Q54GD8", "DDB_G0290631", "Q54XX9", "DDB_G0290631", "Q8T8P3", "DDB_G0293194", "Q54N40", "DDB_G0285523", "Q55FL0", "DDB_G0268564", "Q54VX0", "DDB_G0280367", "Q86AC7", "DDB_G0276913", "Q54H86", "DDB_G0289623", "Q54DG1", "DDB_G0292270", "Q54C55", "DDB_G0293264", "Q54CL3", "DDB_G0292870", "Q76P23", "DDB_G0272346", "Q1ZXK7", "DDB_G0276169", "Q550G0", "DDB_G0277113", "DDB_G0274873", "Q555I0", "DDB_G0274873", "Q54ZX5", "DDB_G0290631", "Q54FR4", "DDB_G0290631", "Q54GD8", "DDB_G0290631", "Q54XX9", "DDB_G0290631", "Q8T8P3", "DDB_G0293194", "Q54N40", "DDB_G0285523", "Q55FL0", "DDB_G0268564", "Q54VX0", "DDB_G0280367", "Q86AC7", "DDB_G0276913", "Q54H86", "DDB_G0289623", "Q54DG1", "DDB_G0292270", "Q54C55", "DDB_G0293264", "Q54CL3", "DDB_G0292870", "Q76P23", "DDB_G0272346", "Q1ZXK7", "DDB_G0276169", "Q550G0", "DDB_G0277113" ] }, "reaction_10625929": { "compartment": "compartment_17947", "id": "reaction_10625929", "reactome": "R-DDI-9603784", "name": "PEX19:class I PMP binds PEX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10625897", "species_10590211" ], "products": [ "species_10625899" ], "modifiers": [], "additional_components": [ "Q555I0", "DDB_G0274873", "Q54ZX5", "DDB_G0290631", "Q54FR4", "DDB_G0290631", "Q54GD8", "DDB_G0290631", "Q54XX9", "DDB_G0290631", "Q8T8P3", "DDB_G0293194", "Q54N40", "DDB_G0285523", "Q55FL0", "DDB_G0268564", "Q54VX0", "DDB_G0280367", "Q86AC7", "DDB_G0276913", "Q54H86", "DDB_G0289623", "Q54DG1", "DDB_G0292270", "Q54C55", "DDB_G0293264", "Q54CL3", "DDB_G0292870", "Q76P23", "DDB_G0272346", "Q1ZXK7", "DDB_G0276169", "Q550G0", "DDB_G0277113", "DDB_G0281213", "Q54U86", "DDB_G0281213", "Q555I0", "DDB_G0274873", "Q54ZX5", "DDB_G0290631", "Q54FR4", "DDB_G0290631", "Q54GD8", "DDB_G0290631", "Q54XX9", "DDB_G0290631", "Q8T8P3", "DDB_G0293194", "Q54N40", "DDB_G0285523", "Q55FL0", "DDB_G0268564", "Q54VX0", "DDB_G0280367", "Q86AC7", "DDB_G0276913", "Q54H86", "DDB_G0289623", "Q54DG1", "DDB_G0292270", "Q54C55", "DDB_G0293264", "Q54CL3", "DDB_G0292870", "Q76P23", "DDB_G0272346", "Q1ZXK7", "DDB_G0276169", "Q550G0", "DDB_G0277113" ] }, "reaction_10604817": { "compartment": "compartment_70101", "id": "reaction_10604817", "reactome": "R-DDI-5226999", "name": "ADD1:ADD3 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604813", "species_10604805" ], "products": [ "species_10604815" ], "modifiers": [], "additional_components": [ "Q54T47", "DDB_G0282009", "DDB_G0279449", "Q54WT5", "DDB_G0279449", "Q54T47", "DDB_G0282009" ] }, "reaction_10605174": { "compartment": "compartment_70101", "id": "reaction_10605174", "reactome": "R-DDI-5339528", "name": "TUSC3 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10605171", "catalyst" ] ], "additional_components": [ "DDB_G0285537" ] }, "reaction_10604809": { "compartment": "compartment_70101", "id": "reaction_10604809", "reactome": "R-DDI-5226979", "name": "ADD1:ADD2 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604805", "species_10604800" ], "products": [ "species_10604807" ], "modifiers": [], "additional_components": [ "DDB_G0279449", "Q54T47", "DDB_G0282009", "Q54T47", "DDB_G0282009", "Q54WT5", "DDB_G0279449" ] }, "reaction_10605163": { "compartment": "compartment_70101", "id": "reaction_10605163", "reactome": "R-DDI-5336466", "name": "MRS2 transports Mg2+ from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29926" ], "products": [ "species_109496" ], "modifiers": [ [ "species_10605160", "catalyst" ] ], "additional_components": [ "DDB_G0275813" ] }, "reaction_10605179": { "compartment": "compartment_70101", "id": "reaction_10605179", "reactome": "R-DDI-5339538", "name": "MAGT1 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10605176", "catalyst" ] ], "additional_components": [ "DDB_G0285537" ] }, "reaction_10582416": { "compartment": "compartment_7660", "id": "reaction_10582416", "reactome": "R-DDI-77090", "name": "Methylation of GMP-cap by RNA Methyltransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10582409" ], "products": [ "species_10582382", "species_77502", "species_10582413", "species_10580699", "species_10578881" ], "modifiers": [ [ "species_10582409", "catalyst" ] ], "additional_components": [ "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661", "DDB_G0287661", "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661" ] }, "reaction_10582402": { "compartment": "compartment_7660", "id": "reaction_10582402", "reactome": "R-DDI-77081", "name": "Formation of the CE:GMP intermediate complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582392", "species_113571" ], "products": [ "species_10582399", "species_111349" ], "modifiers": [ [ "species_10582392", "catalyst" ] ], "additional_components": [ "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661", "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661", "species_113578", "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661" ] }, "reaction_10582418": { "compartment": "compartment_7660", "id": "reaction_10582418", "reactome": "R-DDI-77094", "name": "Formation of cap binding complex (CBC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10578795", "species_10578800" ], "products": [ "species_10578802" ], "modifiers": [], "additional_components": [ "DDB_G0287197", "DDB_G0269814", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197" ] }, "reaction_10582420": { "compartment": "compartment_7660", "id": "reaction_10582420", "reactome": "R-DDI-77095", "name": "Recognition and binding of the mRNA cap by the cap-binding complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10578802", "species_10578881" ], "products": [ "species_10578883" ], "modifiers": [], "additional_components": [ "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197" ] }, "reaction_10582407": { "compartment": "compartment_7660", "id": "reaction_10582407", "reactome": "R-DDI-77083", "name": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582399" ], "products": [ "species_10582404" ], "modifiers": [ [ "species_10582399", "catalyst" ] ], "additional_components": [ "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661", "species_113578", "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661", "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661", "species_113578" ] }, "reaction_10582390": { "compartment": "compartment_7660", "id": "reaction_10582390", "reactome": "R-DDI-77077", "name": "Capping complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_72084", "species_29428", "species_10582384" ], "products": [ "species_10582388" ], "modifiers": [], "additional_components": [ "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661", "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661" ] }, "reaction_10582395": { "compartment": "compartment_7660", "id": "reaction_10582395", "reactome": "R-DDI-77078", "name": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582388" ], "products": [ "species_113550", "species_10582392" ], "modifiers": [ [ "species_10582388", "catalyst" ] ], "additional_components": [ "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661", "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661", "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661" ] }, "reaction_10582411": { "compartment": "compartment_7660", "id": "reaction_10582411", "reactome": "R-DDI-77085", "name": "Dissociation of transcript with 5'-GMP from GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582404" ], "products": [ "species_10582409" ], "modifiers": [], "additional_components": [ "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661", "Q54HV6", "DDB_G0289199", "Q54Y13", "DDB_G0278479", "Q54C29", "DDB_G0293228", "Q86KZ2", "DDB_G0272362", "Q55G81", "DDB_G0267414", "Q55CT8", "DDB_G0269906", "Q54I13", "DDB_G0289079", "P54685", "DDB_G0285417", "Q55F19", "DDB_G0268668", "Q55FP1", "DDB_G0268014", "Q86IB5", "DDB_G0275517", "O00835", "DDB_G0278729", "Q54P04", "DDB_G0284891", "Q54R66", "DDB_G0283365", "Q55GG8", "DDB_G0268306", "Q54EH2", "DDB_G0291636", "Q54J75", "DDB_G0288257", "Q54DH7", "DDB_G0292244", "P35084", "DDB_G0279193", "Q54YW8", "DDB_G0278039", "Q54FA8", "DDB_G0291037", "Q86JJ5", "DDB_G0277677", "Q54S04", "DDB_G0282739", "Q55AB6", "DDB_G0272036", "Q54WV4", "DDB_G0279377", "Q54KT7", "DDB_G0287131", "Q54K42", "DDB_G0287661" ] }, "reaction_10624148": { "compartment": "compartment_7660", "id": "reaction_10624148", "reactome": "R-DDI-8979071", "name": "KDM6B binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602196", "species_111793" ], "products": [ "species_10602198" ], "modifiers": [], "additional_components": [ "DDB_G0269194", "species_71067", "O77033", "DDB_G0269194" ] }, "reaction_10602201": { "compartment": "compartment_7660", "id": "reaction_10602201", "reactome": "R-DDI-3222593", "name": "KDM6B demethylates H3K27me3 on p16INK4A promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602189", "species_113671" ], "products": [ "species_10602191", "species_159939" ], "modifiers": [ [ "species_10602198", "catalyst" ] ], "additional_components": [ "Q54F38", "DDB_G0291185", "O15819", "DDB_G0267402", "Q76NW2", "DDB_G0276863", "O15819", "DDB_G0267402", "Q54F38", "DDB_G0291185", "Q76NW2", "DDB_G0276863", "species_71067", "O77033", "DDB_G0269194" ] }, "reaction_10594065": { "compartment": "compartment_70101", "id": "reaction_10594065", "reactome": "R-DDI-708349", "name": "Activated NOD2 oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584517" ], "products": [ "species_10584519" ], "modifiers": [], "additional_components": [ "Q86KC0", "DDB_G0274183", "species_708341", "Q86KC0", "DDB_G0274183", "species_708341" ] }, "reaction_10594037": { "compartment": "compartment_70101", "id": "reaction_10594037", "reactome": "R-DDI-622310", "name": "Activated NOD1 oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584509" ], "products": [ "species_10584513" ], "modifiers": [], "additional_components": [ "species_622271", "Q86KC0", "DDB_G0274183", "species_622271", "Q86KC0", "DDB_G0274183" ] }, "reaction_10627336": { "compartment": "compartment_70101", "id": "reaction_10627336", "reactome": "R-DDI-9676160", "name": "AAMP binds NOD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10627244", "species_10584515" ], "products": [ "species_10627334" ], "modifiers": [], "additional_components": [ "DDB_G0269344", "DDB_G0274183", "Q86KC0", "DDB_G0274183", "Q55E90", "DDB_G0269344" ] }, "reaction_10584557": { "compartment": "compartment_70101", "id": "reaction_10584557", "reactome": "R-DDI-168405", "name": "Activated NOD oligomer recruites RIP2 (RICK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584553", "species_10584521" ], "products": [ "species_10584555" ], "modifiers": [], "additional_components": [ "Q54IP4", "DDB_G0288617", "Q54Y55", "DDB_G0278409", "Q86HG9", "DDB_G0271682", "Q54RB7", "DDB_G0283267", "Q54U31", "DDB_G0281343", "Q54G43", "DDB_G0290451", "species_622271", "Q86KC0", "DDB_G0274183", "species_708341", "Q54IP4", "DDB_G0288617", "Q54Y55", "DDB_G0278409", "Q86HG9", "DDB_G0271682", "Q54RB7", "DDB_G0283267", "Q54U31", "DDB_G0281343", "Q54G43", "DDB_G0290451", "species_622271", "Q86KC0", "DDB_G0274183", "species_708341" ] }, "reaction_10584511": { "compartment": "compartment_70101", "id": "reaction_10584511", "reactome": "R-DDI-168400", "name": "iE-DAP elicits a NOD1 response", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10584507", "species_622271" ], "products": [ "species_10584509" ], "modifiers": [], "additional_components": [ "DDB_G0274183", "species_622271", "Q86KC0", "DDB_G0274183" ] }, "reaction_10584559": { "compartment": "compartment_70101", "id": "reaction_10584559", "reactome": "R-DDI-168412", "name": "MDP elicits a NOD2 response", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_708341", "species_10584515" ], "products": [ "species_10584517" ], "modifiers": [], "additional_components": [ "DDB_G0274183", "Q86KC0", "DDB_G0274183", "species_708341" ] }, "reaction_10615701": { "compartment": "compartment_1470028", "id": "reaction_10615701", "reactome": "R-DDI-6798751", "name": "Exocytosis of azurophil granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615569" ], "products": [ "species_10615699" ], "modifiers": [], "additional_components": [ "P13723", "DDB_G0287033", "Q559Q3", "DDB_G0272298", "Q54SZ9", "DDB_G0287185", "Q55BL4", "DDB_G0287185", "Q54SW1", "DDB_G0287185", "Q54SW2", "DDB_G0287185", "Q54TL9", "DDB_G0287185", "Q54KP7", "DDB_G0287185", "Q54YD2", "DDB_G0287185", "Q54MV4", "DDB_G0287185", "Q54SZ8", "DDB_G0287185", "Q54VE2", "DDB_G0280423", "Q54P50", "DDB_G0287731", "B0G108", "DDB_G0287731", "Q554H6", "DDB_G0287731", "Q54JY8", "DDB_G0287731", "Q86HR5", "DDB_G0274461", "P34036", "DDB_G0276355", "P34114", "DDB_G0291123", "Q00766", "DDB_G0281383", "Q54QQ0", "DDB_G0283701", "Q8MML4", "DDB_G0274551", "Q54F36", "DDB_G0291137", "Q54XV8", "DDB_G0278563", "Q54HT4", "DDB_G0289231", "Q54H23", "DDB_G0289749", "Q54SE2", "DDB_G0282517", "Q55F06", "DDB_G0279583", "Q54WK5", "DDB_G0279583", "Q54JM5", "DDB_G0287953", "Q54I39", "DDB_G0289029", "Q55FM7", "DDB_G0268034", "O96621", "DDB_G0272106", "C7FZY2", "DDB_G0295845", "Q553U5", "DDB_G0275179", "Q54ES9", "DDB_G0291358", "P54654", "DDB_G0288769", "Q552J0", "DDB_G0276233", "C7G009", "DDB_G0295811", "Q557G3", "DDB_G0273467", "Q54WW0", "DDB_G0290421", "Q54G40", "DDB_G0290421", "Q54EG4", "DDB_G0291524", "Q55B10", "DDB_G0271490", "P32256", "DDB_G0269196", "P34098", "DDB_G0292206", "Q6TMK4", "DDB_G0277275", "Q54LD6", "DDB_G0286691", "P10901", "DDB_G0274391", "Q551C1", "DDB_G0276661", "P90532", "DDB_G0288065", "Q55G10", "DDB_G0268472", "Q54HL4", "DDB_G0289365", "Q54JY2", "DDB_G0287739", "Q1ZXG4", "DDB_G0282361", "P24639", "DDB_G0269160", "Q54PW0", "DDB_G0284261", "Q54HV8", "DDB_G0289195", "Q54YA2", "DDB_G0278341", "Q55BA2", "DDB_G0271242", "Q54GE1", "DDB_G0290217", "P34114", "DDB_G0291123", "Q00766", "DDB_G0281383", "Q54I39", "DDB_G0289029", "P10901", "DDB_G0274391", "Q551C1", "DDB_G0276661", "P90532", "DDB_G0288065", "Q54G40", "DDB_G0290421", "Q54WW0", "DDB_G0290421", "Q552J0", "DDB_G0276233", "P34098", "DDB_G0292206", "Q55FM7", "DDB_G0268034", "Q553U5", "DDB_G0275179", "Q55BA2", "DDB_G0271242", "Q6TMK4", "DDB_G0277275", "Q54QQ0", "DDB_G0283701", "P24639", "DDB_G0269160", "Q54PW0", "DDB_G0284261", "Q55G10", "DDB_G0268472", "Q54YA2", "DDB_G0278341", "Q1ZXG4", "DDB_G0282361", "Q54GE1", "DDB_G0290217", "P13723", "DDB_G0287033", "Q559Q3", "DDB_G0272298", "Q86HR5", "DDB_G0274461", "B0G108", "DDB_G0287731", "Q54JY8", "DDB_G0287731", "Q54P50", "DDB_G0287731", "Q554H6", "DDB_G0287731", "P34036", "DDB_G0276355", "Q54F36", "DDB_G0291137", "Q54XV8", "DDB_G0278563", "Q8MML4", "DDB_G0274551", "Q55F06", "DDB_G0279583", "Q54WK5", "DDB_G0279583", "Q54H23", "DDB_G0289749", "Q54HT4", "DDB_G0289231", "C7FZY2", "DDB_G0295845", "Q54ES9", "DDB_G0291358", "C7G009", "DDB_G0295811", "Q557G3", "DDB_G0273467", "P32256", "DDB_G0269196", "Q54HL4", "DDB_G0289365", "Q54JY2", "DDB_G0287739", "Q54SE2", "DDB_G0282517", "Q54JM5", "DDB_G0287953", "O96621", "DDB_G0272106", "P54654", "DDB_G0288769", "Q54SZ9", "DDB_G0287185", "Q54TL9", "DDB_G0287185", "Q54YD2", "DDB_G0287185", "Q54KP7", "DDB_G0287185", "Q55BL4", "DDB_G0287185", "Q54MV4", "DDB_G0287185", "Q54SW1", "DDB_G0287185", "Q54SW2", "DDB_G0287185", "Q54SZ8", "DDB_G0287185", "Q54LD6", "DDB_G0286691", "Q54VE2", "DDB_G0280423", "Q54HV8", "DDB_G0289195", "Q54EG4", "DDB_G0291524", "Q55B10", "DDB_G0271490" ] }, "reaction_10616165": { "compartment": "compartment_6800424", "id": "reaction_10616165", "reactome": "R-DDI-6800426", "name": "Exocytosis of ficolin-rich granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616149" ], "products": [ "species_10616163" ], "modifiers": [], "additional_components": [ "Q1ZXA8", "DDB_G0292160", "Q54QG5", "DDB_G0283893", "P54642", "DDB_G0274381", "Q54MJ8", "DDB_G0285897", "Q54H23", "DDB_G0289749", "Q557H3", "DDB_G0273473", "Q54R04", "DDB_G0283525", "Q86JN1", "DDB_G0272062", "Q55D50", "DDB_G0269790", "Q869Q3", "DDB_G0274519", "Q86KI1", "DDB_G0273439", "Q54E04", "DDB_G0291858", "Q869V1", "DDB_G0276973", "P34144", "DDB_G0277869", "Q86A88", "DDB_G0274815", "Q54Z16", "DDB_G0289735", "Q54H32", "DDB_G0289735", "Q54U63", "DDB_G0280971", "Q55AV3", "DDB_G0271502", "Q55DM1", "DDB_G0269150", "Q86JF2", "DDB_G0271504", "Q54RQ8", "DDB_G0282925", "Q54CM5", "DDB_G0292814", "Q23924", "DDB_G0284735", "Q54YP0", "DDB_G0278613", "Q559U0", "DDB_G0278613", "Q54U95", "DDB_G0281325", "Q54CI8", "DDB_G0292904", "Q54RQ8", "DDB_G0282925", "Q54U63", "DDB_G0280971", "Q55AV3", "DDB_G0271502", "Q55DM1", "DDB_G0269150", "Q86JF2", "DDB_G0271504", "Q86JN1", "DDB_G0272062", "Q54QG5", "DDB_G0283893", "Q23924", "DDB_G0284735", "Q54E04", "DDB_G0291858", "Q54YP0", "DDB_G0278613", "Q559U0", "DDB_G0278613", "Q54CI8", "DDB_G0292904", "Q86KI1", "DDB_G0273439", "Q55D50", "DDB_G0269790", "Q869Q3", "DDB_G0274519", "Q54CM5", "DDB_G0292814", "P34144", "DDB_G0277869", "Q86A88", "DDB_G0274815", "Q54H23", "DDB_G0289749", "Q869V1", "DDB_G0276973", "Q54U95", "DDB_G0281325", "P54642", "DDB_G0274381", "Q54H32", "DDB_G0289735", "Q54Z16", "DDB_G0289735", "Q54R04", "DDB_G0283525", "Q54MJ8", "DDB_G0285897", "Q557H3", "DDB_G0273473", "Q1ZXA8", "DDB_G0292160" ] }, "reaction_10614836": { "compartment": "compartment_6799713", "id": "reaction_10614836", "reactome": "R-DDI-6798747", "name": "Exocytosis of tertiary granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614736" ], "products": [ "species_10614834" ], "modifiers": [], "additional_components": [ "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q55GA1", "DDB_G0293626", "Q54BH1", "DDB_G0293626", "P54642", "DDB_G0274381", "Q55D50", "DDB_G0269790", "Q55CV4", "DDB_G0270682", "Q55CV5", "DDB_G0269110", "Q55CV7", "DDB_G0270986", "Q55CW7", "DDB_G0269872", "Q54YP0", "DDB_G0278613", "Q559U0", "DDB_G0278613", "Q54QG5", "DDB_G0283893", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "P18613", "DDB_G0291237", "Q86JN1", "DDB_G0272062", "P32253", "DDB_G0281385", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "Q54LX9", "DDB_G0286315", "Q869V1", "DDB_G0276973", "Q54F59", "DDB_G0291091", "Q86J23", "DDB_G0274833", "Q54F95", "DDB_G0290995", "Q54K65", "DDB_G0290995", "Q86GL4", "DDB_G0287101", "Q9XYS3", "DDB_G0289653", "Q54F44", "DDB_G0291117", "Q867X6", "DDB_G0267460", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q86A88", "DDB_G0274815", "Q54Q49", "DDB_G0284155", "Q54UK0", "DDB_G0281031", "Q54WR4", "DDB_G0279483", "Q54Z25", "DDB_G0277949", "Q23924", "DDB_G0284735", "Q54U95", "DDB_G0281325", "Q54U08", "DDB_G0281401", "Q54RQ8", "DDB_G0282925", "Q54U63", "DDB_G0280971", "Q86JF2", "DDB_G0271504", "Q55AV3", "DDB_G0271502", "Q55DM1", "DDB_G0269150", "Q54CM5", "DDB_G0292814", "P36410", "DDB_G0281337", "Q54L55", "DDB_G0286891", "Q551T0", "DDB_G0286891", "Q553A4", "DDB_G0286891", "Q55E61", "DDB_G0286891", "Q86H52", "DDB_G0286891", "Q867X6", "DDB_G0267460", "Q86JN1", "DDB_G0272062", "Q54QG5", "DDB_G0283893", "Q23924", "DDB_G0284735", "Q54BH1", "DDB_G0293626", "Q55GA1", "DDB_G0293626", "Q54F95", "DDB_G0290995", "Q54K65", "DDB_G0290995", "Q55CV4", "DDB_G0270682", "Q55CV5", "DDB_G0269110", "Q55CV7", "DDB_G0270986", "Q55CW7", "DDB_G0269872", "Q86A88", "DDB_G0274815", "Q869V1", "DDB_G0276973", "Q54U08", "DDB_G0281401", "P32254", "DDB_G0283537", "Q54QY0", "DDB_G0283547", "Q54VD5", "DDB_G0280437", "Q55CA9", "DDB_G0270140", "Q55CB0", "DDB_G0270138", "Q55CB7", "DDB_G0270126", "Q55CB8", "DDB_G0270124", "Q55CB9", "DDB_G0270736", "Q55CC0", "DDB_G0270122", "Q75J93", "DDB_G0277381", "P03967", "DDB_G0292996", "P15064", "DDB_G0293434", "P32252", "DDB_G0292998", "P32253", "DDB_G0281385", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54RQ8", "DDB_G0282925", "Q54U63", "DDB_G0280971", "Q55AV3", "DDB_G0271502", "Q55DM1", "DDB_G0269150", "Q86JF2", "DDB_G0271504", "P36410", "DDB_G0281337", "Q54YP0", "DDB_G0278613", "Q559U0", "DDB_G0278613", "Q55D50", "DDB_G0269790", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "Q54CM5", "DDB_G0292814", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54U95", "DDB_G0281325", "Q54F59", "DDB_G0291091", "Q54WR4", "DDB_G0279483", "Q54Z25", "DDB_G0277949", "Q54Q49", "DDB_G0284155", "Q54UK0", "DDB_G0281031", "P54642", "DDB_G0274381", "Q55E61", "DDB_G0286891", "Q86H52", "DDB_G0286891", "Q54L55", "DDB_G0286891", "Q551T0", "DDB_G0286891", "Q553A4", "DDB_G0286891", "Q86J23", "DDB_G0274833", "Q54LX9", "DDB_G0286315", "Q54F44", "DDB_G0291117", "Q86GL4", "DDB_G0287101", "Q9XYS3", "DDB_G0289653" ] }, "reaction_10616436": { "compartment": "compartment_984", "id": "reaction_10616436", "reactome": "R-DDI-6800434", "name": "Exocytosis of ficolin-rich granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10616414" ], "products": [ "species_10616434" ], "modifiers": [], "additional_components": [ "Q54UJ0", "DDB_G0281051", "P04989", "DDB_G0279799", "Q23894", "DDB_G0283867", "Q54RQ2", "DDB_G0282991", "Q54TR1", "DDB_G0281605", "Q54UH2", "DDB_G0282991", "Q54UH3", "DDB_G0282991", "Q86KD4", "DDB_G0282991", "Q54UB5", "DDB_G0281315", "Q86JA1", "DDB_G0276917", "Q54PN7", "DDB_G0284415", "Q556L1", "DDB_G0272590", "P90532", "DDB_G0288065", "P15112", "DDB_G0288373", "Q55GA9", "DDB_G0267742", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "O96626", "DDB_G0288319", "Q54I79", "DDB_G0288937", "Q54JY2", "DDB_G0287739", "C7G034", "DDB_G0285063", "O96621", "DDB_G0272106", "Q54PG1", "DDB_G0284589", "Q54YA2", "DDB_G0278341", "B0G198", "DDB_G0295683", "Q54GE1", "DDB_G0290217", "Q55E06", "DDB_G0269444", "Q54QQ0", "DDB_G0283701", "Q54RF5", "DDB_G0283247", "Q552J0", "DDB_G0276233", "Q54I82", "DDB_G0288933", "Q75JR2", "DDB_G0272210", "Q5R1U3", "DDB_G0277001", "Q556T3", "DDB_G0273107", "Q54QS2", "DDB_G0283663", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54B14", "DDB_G0293986", "Q55FR5", "DDB_G0267990", "Q54K94", "DDB_G0287569", "Q556U5", "DDB_G0273095", "Q54QV7", "DDB_G0283575", "Q54VI4", "DDB_G0280317", "Q556G3", "DDB_G0272632", "Q556P3", "DDB_G0273153", "Q55FF3", "DDB_G0268138", "Q86AU1", "DDB_G0274263", "Q54PF1", "DDB_G0284601", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "C7G028", "DDB_G0284307", "Q8MUF9", "DDB_G0269200", "Q5V9E9", "DDB_G0283673", "Q54UQ2", "DDB_G0280897", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "Q23919", "DDB_G0288483", "Q54S93", "DDB_G0282595", "O96923", "DDB_G0291125", "P10733", "DDB_G0289327", "Q551I6", "DDB_G0276571", "Q86CR9", "DDB_G0271096", "Q54QS3", "DDB_G0283661", "Q54MA9", "DDB_G0286069", "Q54W35", "DDB_G0279909", "Q86A67", "DDB_G0274375", "Q54DD0", "DDB_G0292266", "Q54NQ0", "DDB_G0285105", "Q86IJ1", "DDB_G0272566", "Q54BC6", "DDB_G0293752", "Q54QK4", "DDB_G0283795", "Q1ZXD3", "DDB_G0288621", "Q86KD1", "DDB_G0274167", "Q55C75", "DDB_G0270188", "Q54WI8", "DDB_G0279633", "O77229", "DDB_G0274595", "Q00766", "DDB_G0281383", "Q54IS1", "DDB_G0288563", "Q54L24", "DDB_G0286945", "O76856", "DDB_G0279411", "P36415", "DDB_G0269144", "P54651", "DDB_G0267400", "Q55C24", "DDB_G0270260", "P52922", "DDB_G0269148", "Q54QR2", "DDB_G0283679", "P34118", "DDB_G0269156", "Q54DM7", "DDB_G0292122", "Q55G04", "DDB_G0268538", "Q86A21", "DDB_G0272969", "P34093", "DDB_G0279911", "Q555L5", "DDB_G0274859", "Q54NE6", "DDB_G0285311", "Q54J84", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54VR1", "DDB_G0288221", "C7G034", "DDB_G0285063", "Q8MUF9", "DDB_G0269200", "Q54PG1", "DDB_G0284589", "Q55GA9", "DDB_G0267742", "Q55E06", "DDB_G0269444", "Q556U5", "DDB_G0273095", "P34093", "DDB_G0279911", "Q86JA1", "DDB_G0276917", "Q86A21", "DDB_G0272969", "Q54UB5", "DDB_G0281315", "Q55G04", "DDB_G0268538", "Q54UJ0", "DDB_G0281051", "Q54DM7", "DDB_G0292122", "Q54NQ0", "DDB_G0285105", "P34118", "DDB_G0269156", "Q86IJ1", "DDB_G0272566", "O96621", "DDB_G0272106", "Q54QR2", "DDB_G0283679", "Q54BC6", "DDB_G0293752", "Q1ZXD3", "DDB_G0288621", "P54651", "DDB_G0267400", "Q55C75", "DDB_G0270188", "Q54JY2", "DDB_G0287739", "P36415", "DDB_G0269144", "Q54WI8", "DDB_G0279633", "Q54L24", "DDB_G0286945", "Q54K94", "DDB_G0287569", "Q00766", "DDB_G0281383", "Q23919", "DDB_G0288483", "P52922", "DDB_G0269148", "Q556G3", "DDB_G0272632", "Q556P3", "DDB_G0273153", "Q55FF3", "DDB_G0268138", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q54VI4", "DDB_G0280317", "Q86CR9", "DDB_G0271096", "Q54QS3", "DDB_G0283661", "Q54MA9", "DDB_G0286069", "Q54W35", "DDB_G0279909", "Q55C24", "DDB_G0270260", "Q54GE1", "DDB_G0290217", "Q54DD0", "DDB_G0292266", "Q54YA2", "DDB_G0278341", "O96626", "DDB_G0288319", "Q86A67", "DDB_G0274375", "Q54I79", "DDB_G0288937", "Q54QQ0", "DDB_G0283701", "Q552J0", "DDB_G0276233", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54VR1", "DDB_G0288221", "Q54J84", "DDB_G0288221", "P90532", "DDB_G0288065", "Q54NE6", "DDB_G0285311", "Q556L1", "DDB_G0272590", "Q555L5", "DDB_G0274859", "Q54PN7", "DDB_G0284415", "Q54UH2", "DDB_G0282991", "Q54UH3", "DDB_G0282991", "Q86KD4", "DDB_G0282991", "P04989", "DDB_G0279799", "Q23894", "DDB_G0283867", "Q54RQ2", "DDB_G0282991", "Q54TR1", "DDB_G0281605", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "O00897", "DDB_G0269104", "P02599", "DDB_G0279407", "Q7Z2B8", "DDB_G0277917", "P15112", "DDB_G0288373", "Q54IS1", "DDB_G0288563", "Q54QK4", "DDB_G0283795", "P10733", "DDB_G0289327", "Q551I6", "DDB_G0276571", "O96923", "DDB_G0291125", "Q54S93", "DDB_G0282595", "B0G198", "DDB_G0295683", "Q54UQ2", "DDB_G0280897", "Q5V9E9", "DDB_G0283673", "Q54NT2", "DDB_G0284997", "Q54IA6", "DDB_G0288895", "Q75JR2", "DDB_G0272210", "C7G028", "DDB_G0284307", "Q54B14", "DDB_G0293986", "Q54PF1", "DDB_G0284601", "Q55FR5", "DDB_G0267990", "O77229", "DDB_G0274595", "Q86KD1", "DDB_G0274167", "Q54I82", "DDB_G0288933", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q5R1U3", "DDB_G0277001", "O76856", "DDB_G0279411", "Q556T3", "DDB_G0273107", "Q54RF5", "DDB_G0283247" ] }, "reaction_10615963": { "compartment": "compartment_6799351", "id": "reaction_10615963", "reactome": "R-DDI-6799350", "name": "Exocytosis of specific granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615937" ], "products": [ "species_10615961" ], "modifiers": [], "additional_components": [ "Q54I48", "DDB_G0289013", "Q54IJ2", "DDB_G0288717", "Q867X6", "DDB_G0267460", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q86A77", "DDB_G0274331", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "Q54U08", "DDB_G0281401", "Q02465", "DDB_G0289075", "Q54F44", "DDB_G0291117", "Q86GL4", "DDB_G0287101", "Q9XYS3", "DDB_G0289653", "Q54CM5", "DDB_G0292814", "Q54LX9", "DDB_G0286315", "Q54F59", "DDB_G0291091", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "P34138", "DDB_G0277865", "P54637", "DDB_G0282145", "Q86J23", "DDB_G0274833", "Q55BH9", "DDB_G0271342", "Q54EU4", "DDB_G0291332", "Q54HS9", "DDB_G0289247", "Q54DG1", "DDB_G0292270", "Q54F95", "DDB_G0290995", "Q54K65", "DDB_G0290995", "Q55FQ9", "DDB_G0267440", "Q9BKJ9", "DDB_G0287035", "Q9XYS8", "DDB_G0267406", "Q54BH1", "DDB_G0293626", "Q55GA1", "DDB_G0293626", "Q54Z55", "DDB_G0277773", "Q869T7", "DDB_G0274409", "Q54S39", "DDB_G0282683", "O76173", "DDB_G0269174", "Q54L55", "DDB_G0286891", "Q551T0", "DDB_G0286891", "Q553A4", "DDB_G0286891", "Q55E61", "DDB_G0286891", "Q86H52", "DDB_G0286891", "Q54S63", "DDB_G0282651", "Q55EF0", "DDB_G0269262", "Q55EG6", "DDB_G0268910", "Q86JC8", "DDB_G0275955", "Q86JP5", "DDB_G0271980", "Q8T193", "DDB_G0294577", "Q1ZXG2", "DDB_G0294577", "Q1ZXN9", "DDB_G0294577", "Q54E92", "DDB_G0291738", "Q54FL2", "DDB_G0290783", "Q54G48", "DDB_G0290407", "Q54P07", "DDB_G0285051", "Q54S62", "DDB_G0294577", "Q551J1", "DDB_G0276567", "Q55D94", "DDB_G0269738", "Q559U0", "DDB_G0278613", "Q54YP0", "DDB_G0278613", "Q1ZXA8", "DDB_G0292160", "Q54QG5", "DDB_G0283893", "Q54Q49", "DDB_G0284155", "Q54UK0", "DDB_G0281031", "Q54WR4", "DDB_G0279483", "Q54Z25", "DDB_G0277949", "Q55CV4", "DDB_G0270682", "Q55CV5", "DDB_G0269110", "Q55CV7", "DDB_G0270986", "Q55CW7", "DDB_G0269872", "Q867X6", "DDB_G0267460", "O76173", "DDB_G0269174", "Q54QG5", "DDB_G0283893", "Q54BH1", "DDB_G0293626", "Q55GA1", "DDB_G0293626", "Q54F95", "DDB_G0290995", "Q54K65", "DDB_G0290995", "Q54DG1", "DDB_G0292270", "Q55CV4", "DDB_G0270682", "Q55CV5", "DDB_G0269110", "Q55CV7", "DDB_G0270986", "Q55CW7", "DDB_G0269872", "Q54U08", "DDB_G0281401", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54I48", "DDB_G0289013", "Q54IJ2", "DDB_G0288717", "Q54EU4", "DDB_G0291332", "Q54HS9", "DDB_G0289247", "Q55D94", "DDB_G0269738", "Q55BH9", "DDB_G0271342", "Q54YP0", "DDB_G0278613", "Q559U0", "DDB_G0278613", "P18613", "DDB_G0291237", "Q55BW0", "DDB_G0270340", "Q86L51", "DDB_G0272857", "Q54CM5", "DDB_G0292814", "Q54S63", "DDB_G0282651", "Q55EF0", "DDB_G0269262", "Q55EG6", "DDB_G0268910", "Q86JC8", "DDB_G0275955", "Q86JP5", "DDB_G0271980", "Q8T193", "DDB_G0294577", "Q1ZXG2", "DDB_G0294577", "Q1ZXN9", "DDB_G0294577", "Q54E92", "DDB_G0291738", "Q54FL2", "DDB_G0290783", "Q54G48", "DDB_G0290407", "Q54P07", "DDB_G0285051", "Q54S62", "DDB_G0294577", "P34138", "DDB_G0277865", "P54637", "DDB_G0282145", "Q54YE6", "DDB_G0284903", "Q55GN5", "DDB_G0267590", "Q54S39", "DDB_G0282683", "Q869T7", "DDB_G0274409", "Q86A77", "DDB_G0274331", "Q9XYS8", "DDB_G0267406", "Q55FQ9", "DDB_G0267440", "Q9BKJ9", "DDB_G0287035", "Q55E61", "DDB_G0286891", "Q86H52", "DDB_G0286891", "Q54L55", "DDB_G0286891", "Q551T0", "DDB_G0286891", "Q553A4", "DDB_G0286891", "Q54WR4", "DDB_G0279483", "Q54Z25", "DDB_G0277949", "Q54Q49", "DDB_G0284155", "Q54UK0", "DDB_G0281031", "Q54F59", "DDB_G0291091", "Q02465", "DDB_G0289075", "Q551J1", "DDB_G0276567", "Q54LX9", "DDB_G0286315", "Q86J23", "DDB_G0274833", "Q54Z55", "DDB_G0277773", "Q54F44", "DDB_G0291117", "Q86GL4", "DDB_G0287101", "Q9XYS3", "DDB_G0289653", "Q1ZXA8", "DDB_G0292160" ] }, "reaction_10614058": { "compartment": "compartment_6798757", "id": "reaction_10614058", "reactome": "R-DDI-6798739", "name": "Exocytosis of azurophil granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10613932" ], "products": [ "species_10614056" ], "modifiers": [], "additional_components": [ "Q54F95", "DDB_G0290995", "Q54K65", "DDB_G0290995", "Q54U08", "DDB_G0281401", "Q54X10", "DDB_G0279277", "Q54R04", "DDB_G0283525", "Q54DE8", "DDB_G0292310", "Q54ET2", "DDB_G0291352", "P18613", "DDB_G0291237", "Q552S3", "DDB_G0275917", "Q54FL2", "DDB_G0290783", "Q54G48", "DDB_G0290407", "Q54P07", "DDB_G0285051", "Q54S62", "DDB_G0294577", "Q54S63", "DDB_G0282651", "Q55EF0", "DDB_G0269262", "Q55EG6", "DDB_G0268910", "Q86JC8", "DDB_G0275955", "Q86JP5", "DDB_G0271980", "Q8T193", "DDB_G0294577", "Q1ZXG2", "DDB_G0294577", "Q1ZXN9", "DDB_G0294577", "Q54E92", "DDB_G0291738", "Q86JP3", "DDB_G0271984", "Q54FY7", "DDB_G0290529", "Q54P51", "DDB_G0284791", "Q55GG1", "DDB_G0267688", "Q7YXU4", "DDB_G0293008", "Q86K21", "DDB_G0272875", "Q1ZXB3", "DDB_G0291498", "Q54H23", "DDB_G0289749", "Q556J9", "DDB_G0272889", "Q54WE0", "DDB_G0279713", "Q55GN5", "DDB_G0267590", "P54642", "DDB_G0274381", "Q54XS7", "DDB_G0278773", "Q54LZ3", "DDB_G0286293", "Q54E62", "DDB_G0291780", "Q551J1", "DDB_G0276567", "O76173", "DDB_G0269174", "Q1ZXA8", "DDB_G0292160", "Q54P71", "DDB_G0284755", "Q54P72", "DDB_G0284755", "Q54PR9", "DDB_G0284363", "Q6TMJ9", "DDB_G0280061", "Q54GB3", "DDB_G0290363", "Q8T6J2", "DDB_G0274119", "Q8T6J5", "DDB_G0267438", "Q54BT5", "DDB_G0293436", "Q555Z5", "DDB_G0274121", "Q55BC0", "DDB_G0271138", "Q8T5Z7", "DDB_G0291994", "Q8T6J1", "DDB_G0291245", "Q55D50", "DDB_G0269790", "Q54N33", "DDB_G0285537", "P20790", "DDB_G0280043", "P20791", "DDB_G0276399", "Q1ZXE7", "DDB_G0286169", "Q54RY4", "DDB_G0282899", "Q54JT7", "DDB_G0287801", "Q54WG1", "DDB_G0279675", "O76173", "DDB_G0269174", "Q54DE8", "DDB_G0292310", "Q54ET2", "DDB_G0291352", "Q54WG1", "DDB_G0279675", "Q54F95", "DDB_G0290995", "Q54K65", "DDB_G0290995", "Q54X10", "DDB_G0279277", "Q54U08", "DDB_G0281401", "Q552S3", "DDB_G0275917", "P20790", "DDB_G0280043", "P20791", "DDB_G0276399", "Q1ZXE7", "DDB_G0286169", "Q54RY4", "DDB_G0282899", "Q54E62", "DDB_G0291780", "Q54LZ3", "DDB_G0286293", "Q54GB3", "DDB_G0290363", "Q6TMJ9", "DDB_G0280061", "Q54N33", "DDB_G0285537", "Q54P51", "DDB_G0284791", "Q55GG1", "DDB_G0267688", "Q1ZXB3", "DDB_G0291498", "Q54FY7", "DDB_G0290529", "Q7YXU4", "DDB_G0293008", "Q86K21", "DDB_G0272875", "Q8T6J2", "DDB_G0274119", "Q8T6J5", "DDB_G0267438", "Q54BT5", "DDB_G0293436", "Q555Z5", "DDB_G0274121", "Q55BC0", "DDB_G0271138", "Q8T5Z7", "DDB_G0291994", "Q8T6J1", "DDB_G0291245", "P18613", "DDB_G0291237", "Q54JT7", "DDB_G0287801", "Q54S63", "DDB_G0282651", "Q55EF0", "DDB_G0269262", "Q55EG6", "DDB_G0268910", "Q86JC8", "DDB_G0275955", "Q86JP5", "DDB_G0271980", "Q8T193", "DDB_G0294577", "Q1ZXG2", "DDB_G0294577", "Q1ZXN9", "DDB_G0294577", "Q54E92", "DDB_G0291738", "Q54FL2", "DDB_G0290783", "Q54G48", "DDB_G0290407", "Q54P07", "DDB_G0285051", "Q54S62", "DDB_G0294577", "Q54P71", "DDB_G0284755", "Q54P72", "DDB_G0284755", "Q54PR9", "DDB_G0284363", "Q86JP3", "DDB_G0271984", "Q54H23", "DDB_G0289749", "Q556J9", "DDB_G0272889", "Q54WE0", "DDB_G0279713", "Q55GN5", "DDB_G0267590", "P54642", "DDB_G0274381", "Q551J1", "DDB_G0276567", "Q54XS7", "DDB_G0278773", "Q54R04", "DDB_G0283525", "Q55D50", "DDB_G0269790", "Q1ZXA8", "DDB_G0292160" ] }, "reaction_10615338": { "compartment": "compartment_6799371", "id": "reaction_10615338", "reactome": "R-DDI-6798749", "name": "Exocytosis of specific granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615290" ], "products": [ "species_10615336" ], "modifiers": [], "additional_components": [ "Q54B14", "DDB_G0293986", "Q55BA2", "DDB_G0271242", "Q54HV8", "DDB_G0289195", "Q54F36", "DDB_G0291137", "Q54XV8", "DDB_G0278563", "Q8MML4", "DDB_G0274551", "O76856", "DDB_G0279411", "P05095", "DDB_G0268632", "Q54V78", "DDB_G0280565", "Q55D97", "DDB_G0270626", "Q54RX2", "DDB_G0282859", "Q54PB7", "DDB_G0292004", "Q54HL4", "DDB_G0289365", "Q54J84", "DDB_G0288221", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54VR1", "DDB_G0288221", "Q54JM9", "DDB_G0287939", "Q1ZXG2", "DDB_G0294577", "Q1ZXN9", "DDB_G0294577", "Q54E92", "DDB_G0291738", "Q54FL2", "DDB_G0290783", "Q54G48", "DDB_G0290407", "Q54P07", "DDB_G0285051", "Q54S62", "DDB_G0294577", "Q54S63", "DDB_G0282651", "Q55EF0", "DDB_G0269262", "Q55EG6", "DDB_G0268910", "Q86JC8", "DDB_G0275955", "Q86JP5", "DDB_G0271980", "Q8T193", "DDB_G0294577", "Q86IY4", "DDB_G0274339", "Q556T3", "DDB_G0273107", "Q55EK9", "DDB_G0268628", "Q6UK63", "DDB_G0287855", "Q6UK63", "DDB_G0287855", "Q54F36", "DDB_G0291137", "Q54XV8", "DDB_G0278563", "Q8MML4", "DDB_G0274551", "Q55EK9", "DDB_G0268628", "P05095", "DDB_G0268632", "Q54V78", "DDB_G0280565", "Q54B14", "DDB_G0293986", "Q54ME1", "DDB_G0286015", "Q54R55", "DDB_G0288221", "Q54VR1", "DDB_G0288221", "Q54J84", "DDB_G0288221", "Q54JM9", "DDB_G0287939", "Q55BA2", "DDB_G0271242", "Q54RX2", "DDB_G0282859", "Q54HL4", "DDB_G0289365", "Q55D97", "DDB_G0270626", "O76856", "DDB_G0279411", "Q1ZXG2", "DDB_G0294577", "Q1ZXN9", "DDB_G0294577", "Q54E92", "DDB_G0291738", "Q54FL2", "DDB_G0290783", "Q54G48", "DDB_G0290407", "Q54P07", "DDB_G0285051", "Q54S62", "DDB_G0294577", "Q54S63", "DDB_G0282651", "Q55EF0", "DDB_G0269262", "Q55EG6", "DDB_G0268910", "Q86JC8", "DDB_G0275955", "Q86JP5", "DDB_G0271980", "Q8T193", "DDB_G0294577", "Q54PB7", "DDB_G0292004", "Q54HV8", "DDB_G0289195", "Q86IY4", "DDB_G0274339", "Q556T3", "DDB_G0273107" ] }, "reaction_10615210": { "compartment": "compartment_1462052", "id": "reaction_10615210", "reactome": "R-DDI-6798748", "name": "Exocytosis of secretory granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10615050" ], "products": [ "species_10615208" ], "modifiers": [], "additional_components": [ "Q54NQ0", "DDB_G0285105", "Q86A67", "DDB_G0274375", "Q86IJ1", "DDB_G0272566", "P15112", "DDB_G0288373", "Q54IA6", "DDB_G0288895", "Q54NT2", "DDB_G0284997", "Q555L5", "DDB_G0274859", "P34093", "DDB_G0279911", "Q86A21", "DDB_G0272969", "Q55G04", "DDB_G0268538", "Q54DM7", "DDB_G0292122", "P34118", "DDB_G0269156", "Q86CR9", "DDB_G0271096", "Q54QR2", "DDB_G0283679", "Q54QS3", "DDB_G0283661", "Q55C24", "DDB_G0270260", "P54651", "DDB_G0267400", "Q54LY5", "DDB_G0286303", "P36415", "DDB_G0269144", "Q54MA9", "DDB_G0286069", "Q54L24", "DDB_G0286945", "Q54W35", "DDB_G0279909", "Q00766", "DDB_G0281383", "Q54DD0", "DDB_G0292266", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q54VI4", "DDB_G0280317", "Q556G3", "DDB_G0272632", "Q556P3", "DDB_G0273153", "Q55FF3", "DDB_G0268138", "O96626", "DDB_G0288319", "Q54I79", "DDB_G0288937", "Q86KD1", "DDB_G0274167", "B0G198", "DDB_G0295683", "Q54UH3", "DDB_G0282991", "Q86KD4", "DDB_G0282991", "P04989", "DDB_G0279799", "Q23894", "DDB_G0283867", "Q54RQ2", "DDB_G0282991", "Q54TR1", "DDB_G0281605", "Q54UH2", "DDB_G0282991", "Q54E35", "DDB_G0291840", "O77229", "DDB_G0274595", "Q54PF1", "DDB_G0284601", "Q6TMK4", "DDB_G0277275", "C7G028", "DDB_G0284307", "Q54NE6", "DDB_G0285311", "Q54BC6", "DDB_G0293752", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "Q1ZXD3", "DDB_G0288621", "Q55C75", "DDB_G0270188", "Q54WI8", "DDB_G0279633", "C7G034", "DDB_G0285063", "Q54K94", "DDB_G0287569", "Q54PG1", "DDB_G0284589", "Q55E06", "DDB_G0269444", "Q54RF5", "DDB_G0283247", "Q54I82", "DDB_G0288933", "Q5R1U3", "DDB_G0277001", "Q54QS2", "DDB_G0283663", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54UJ0", "DDB_G0281051", "Q54UB5", "DDB_G0281315", "Q86JA1", "DDB_G0276917", "O96923", "DDB_G0291125", "P10733", "DDB_G0289327", "Q551I6", "DDB_G0276571", "Q54PN7", "DDB_G0284415", "Q556L1", "DDB_G0272590", "P90532", "DDB_G0288065", "Q75JR2", "DDB_G0272210", "Q54S93", "DDB_G0282595", "Q6UK63", "DDB_G0287855", "Q54UQ2", "DDB_G0280897", "Q556T3", "DDB_G0273107", "Q5V9E9", "DDB_G0283673", "Q55EK9", "DDB_G0268628", "Q552J0", "DDB_G0276233", "Q55FM7", "DDB_G0268034", "Q54QQ0", "DDB_G0283701", "Q54S93", "DDB_G0282595", "P10733", "DDB_G0289327", "Q551I6", "DDB_G0276571", "O96923", "DDB_G0291125", "P15112", "DDB_G0288373", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136", "Q54UH2", "DDB_G0282991", "Q54UH3", "DDB_G0282991", "Q86KD4", "DDB_G0282991", "P04989", "DDB_G0279799", "Q23894", "DDB_G0283867", "Q54RQ2", "DDB_G0282991", "Q54TR1", "DDB_G0281605", "C7G034", "DDB_G0285063", "Q54PG1", "DDB_G0284589", "Q55E06", "DDB_G0269444", "P34093", "DDB_G0279911", "Q86JA1", "DDB_G0276917", "Q86A21", "DDB_G0272969", "Q54UB5", "DDB_G0281315", "Q55G04", "DDB_G0268538", "Q54UJ0", "DDB_G0281051", "Q54DM7", "DDB_G0292122", "Q54NQ0", "DDB_G0285105", "P34118", "DDB_G0269156", "Q86IJ1", "DDB_G0272566", "Q54QR2", "DDB_G0283679", "Q54BC6", "DDB_G0293752", "Q1ZXD3", "DDB_G0288621", "P54651", "DDB_G0267400", "Q55C75", "DDB_G0270188", "P36415", "DDB_G0269144", "Q54WI8", "DDB_G0279633", "Q54L24", "DDB_G0286945", "Q54K94", "DDB_G0287569", "Q00766", "DDB_G0281383", "Q556G3", "DDB_G0272632", "Q556P3", "DDB_G0273153", "Q55FF3", "DDB_G0268138", "Q86AU1", "DDB_G0274263", "Q54QV7", "DDB_G0283575", "Q54VI4", "DDB_G0280317", "Q86CR9", "DDB_G0271096", "Q54QS3", "DDB_G0283661", "Q54LY5", "DDB_G0286303", "Q54MA9", "DDB_G0286069", "Q54W35", "DDB_G0279909", "Q55C24", "DDB_G0270260", "Q54DD0", "DDB_G0292266", "O96626", "DDB_G0288319", "Q86A67", "DDB_G0274375", "Q54I79", "DDB_G0288937", "Q54QQ0", "DDB_G0283701", "Q55FM7", "DDB_G0268034", "Q552J0", "DDB_G0276233", "Q54E35", "DDB_G0291840", "Q55EK9", "DDB_G0268628", "Q6TMK4", "DDB_G0277275", "P90532", "DDB_G0288065", "Q54NE6", "DDB_G0285311", "Q556L1", "DDB_G0272590", "Q555L5", "DDB_G0274859", "Q54PN7", "DDB_G0284415", "B0G198", "DDB_G0295683", "Q54UQ2", "DDB_G0280897", "Q5V9E9", "DDB_G0283673", "Q6UK63", "DDB_G0287855", "Q54NT2", "DDB_G0284997", "Q54IA6", "DDB_G0288895", "Q75JR2", "DDB_G0272210", "C7G028", "DDB_G0284307", "Q54PF1", "DDB_G0284601", "O77229", "DDB_G0274595", "Q86KD1", "DDB_G0274167", "Q54I82", "DDB_G0288933", "Q9TW32", "DDB_G0269120", "Q9UA41", "DDB_G0280401", "Q54QS2", "DDB_G0283663", "Q5R1U3", "DDB_G0277001", "Q556T3", "DDB_G0273107", "Q54RF5", "DDB_G0283247" ] }, "reaction_10614349": { "compartment": "compartment_876", "id": "reaction_10614349", "reactome": "R-DDI-6798743", "name": "Exocytosis of secretory granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614243" ], "products": [ "species_10614347" ], "modifiers": [], "additional_components": [ "Q54YP0", "DDB_G0278613", "Q559U0", "DDB_G0278613", "Q54K32", "DDB_G0287585", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "P34144", "DDB_G0277869", "Q86KI1", "DDB_G0273439", "Q54GY8", "DDB_G0289827", "Q54CM5", "DDB_G0292814", "Q23924", "DDB_G0284735", "Q54DG1", "DDB_G0292270", "Q8MYF2", "DDB_G0277441", "Q55FU9", "DDB_G0268402", "Q54RY4", "DDB_G0282899", "P20790", "DDB_G0280043", "P20791", "DDB_G0276399", "Q1ZXE7", "DDB_G0286169", "Q8T6J2", "DDB_G0274119", "Q8T6J5", "DDB_G0267438", "Q54BT5", "DDB_G0293436", "Q555Z5", "DDB_G0274121", "Q55BC0", "DDB_G0271138", "Q8T5Z7", "DDB_G0291994", "Q8T6J1", "DDB_G0291245", "Q54LZ3", "DDB_G0286293", "Q54E04", "DDB_G0291858", "Q54DA7", "DDB_G0292406", "Q54CI8", "DDB_G0292904", "Q86JP3", "DDB_G0271984", "Q869Q3", "DDB_G0274519", "Q55FK2", "DDB_G0268068", "P36411", "DDB_G0269236", "Q557I4", "DDB_G0273419", "Q55CT4", "DDB_G0270994", "Q55CY7", "DDB_G0270670", "P34138", "DDB_G0277865", "Q54FK4", "DDB_G0290833", "Q54FK8", "DDB_G0290829", "Q1ZXB8", "DDB_G0294571", "Q54K69", "DDB_G0287553", "Q1ZXB9", "DDB_G0290831", "Q54FK5", "DDB_G0290789", "Q54FK7", "DDB_G0290779", "Q552H0", "DDB_G0294571", "Q1ZXB7", "DDB_G0290791", "Q54FK2", "DDB_G0290793", "Q54K32", "DDB_G0287585", "O00899", "DDB_G0269140", "Q54I34", "DDB_G0289033", "Q23924", "DDB_G0284735", "Q54GY8", "DDB_G0289827", "Q54E04", "DDB_G0291858", "Q8MYF2", "DDB_G0277441", "Q54CI8", "DDB_G0292904", "Q55FU9", "DDB_G0268402", "P34138", "DDB_G0277865", "Q86KI1", "DDB_G0273439", "Q869Q3", "DDB_G0274519", "Q54DG1", "DDB_G0292270", "Q54RY4", "DDB_G0282899", "P20790", "DDB_G0280043", "P20791", "DDB_G0276399", "Q1ZXE7", "DDB_G0286169", "Q54DA7", "DDB_G0292406", "Q54LZ3", "DDB_G0286293", "Q86JP3", "DDB_G0271984", "Q55FK2", "DDB_G0268068", "P36411", "DDB_G0269236", "Q54D31", "DDB_G0292610", "Q55GM0", "DDB_G0292610", "Q54LD2", "DDB_G0292610", "Q54P67", "DDB_G0292610", "Q54QZ0", "DDB_G0292610", "Q54VJ6", "DDB_G0292610", "Q54WQ8", "DDB_G0292610", "Q1ZXI3", "DDB_G0292610", "Q54XB6", "DDB_G0292610", "Q54CZ8", "DDB_G0292610", "Q55GL9", "DDB_G0292610", "Q55CY7", "DDB_G0270670", "Q557I4", "DDB_G0273419", "Q55CT4", "DDB_G0270994", "Q8T6J2", "DDB_G0274119", "Q8T6J5", "DDB_G0267438", "Q54BT5", "DDB_G0293436", "Q555Z5", "DDB_G0274121", "Q55BC0", "DDB_G0271138", "Q8T5Z7", "DDB_G0291994", "Q8T6J1", "DDB_G0291245", "Q54YP0", "DDB_G0278613", "Q559U0", "DDB_G0278613", "Q54CM5", "DDB_G0292814", "P34144", "DDB_G0277869", "Q54FK5", "DDB_G0290789", "Q54FK7", "DDB_G0290779", "Q54FK8", "DDB_G0290829", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "Q1ZXB8", "DDB_G0294571", "Q552H0", "DDB_G0294571", "Q1ZXB9", "DDB_G0290831", "Q54FK2", "DDB_G0290793", "Q54FK4", "DDB_G0290833" ] }, "reaction_10614542": { "compartment": "compartment_6800173", "id": "reaction_10614542", "reactome": "R-DDI-6798745", "name": "Exocytosis of tertiary granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10614462" ], "products": [ "species_10614540" ], "modifiers": [], "additional_components": [ "Q55FR5", "DDB_G0267990", "Q54JM9", "DDB_G0287939", "Q54XV8", "DDB_G0278563", "Q8MML4", "DDB_G0274551", "Q54F36", "DDB_G0291137", "Q54HL4", "DDB_G0289365", "O76856", "DDB_G0279411", "Q54RQ2", "DDB_G0282991", "Q54TR1", "DDB_G0281605", "Q54UH2", "DDB_G0282991", "Q54UH3", "DDB_G0282991", "Q86KD4", "DDB_G0282991", "P04989", "DDB_G0279799", "Q23894", "DDB_G0283867", "Q54RX2", "DDB_G0282859", "Q6UK63", "DDB_G0287855", "Q5R1U3", "DDB_G0277001", "Q75JR2", "DDB_G0272210", "Q55D97", "DDB_G0270626", "Q54I82", "DDB_G0288933", "B0G198", "DDB_G0295683", "Q86A67", "DDB_G0274375", "P05095", "DDB_G0268632", "Q54V78", "DDB_G0280565", "Q54B14", "DDB_G0293986", "Q550I3", "DDB_G0277093", "Q23919", "DDB_G0288483", "P52922", "DDB_G0269148", "Q6UK63", "DDB_G0287855", "Q54F36", "DDB_G0291137", "Q54XV8", "DDB_G0278563", "Q8MML4", "DDB_G0274551", "Q550I3", "DDB_G0277093", "Q75JR2", "DDB_G0272210", "Q54B14", "DDB_G0293986", "Q54UH2", "DDB_G0282991", "Q54UH3", "DDB_G0282991", "Q86KD4", "DDB_G0282991", "P04989", "DDB_G0279799", "Q23894", "DDB_G0283867", "Q54RQ2", "DDB_G0282991", "Q54TR1", "DDB_G0281605", "P05095", "DDB_G0268632", "Q54V78", "DDB_G0280565", "Q55FR5", "DDB_G0267990", "P52922", "DDB_G0269148", "Q54JM9", "DDB_G0287939", "Q23919", "DDB_G0288483", "Q54RX2", "DDB_G0282859", "Q54HL4", "DDB_G0289365", "Q86A67", "DDB_G0274375", "Q55D97", "DDB_G0270626", "Q54I82", "DDB_G0288933", "Q5R1U3", "DDB_G0277001", "O76856", "DDB_G0279411", "B0G198", "DDB_G0295683" ] }, "reaction_10612848": { "compartment": "compartment_21994", "id": "reaction_10612848", "reactome": "R-DDI-6789031", "name": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1222719", "species_6788973", "species_1470067" ], "products": [ "species_1222475", "species_6789150" ], "modifiers": [ [ "species_10612845", "catalyst" ] ], "additional_components": [ "Q6TMK4", "DDB_G0277275", "CHEBI:55376" ] }, "reaction_10612851": { "compartment": "compartment_1222282", "id": "reaction_10612851", "reactome": "R-DDI-6789126", "name": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1222719", "species_6788973", "species_1470067" ], "products": [ "species_1222475", "species_6789150" ], "modifiers": [ [ "species_10612843", "catalyst" ] ], "additional_components": [ "Q6TMK4", "DDB_G0277275", "CHEBI:55376" ] }, "reaction_10612853": { "compartment": "compartment_21994", "id": "reaction_10612853", "reactome": "R-DDI-6789136", "name": "Myeloperoxidase (MPO) binds to the bacterial cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10612843", "species_983438" ], "products": [ "species_10612845" ], "modifiers": [], "additional_components": [ "Q6TMK4", "DDB_G0277275", "CHEBI:55376", "Q6TMK4", "DDB_G0277275", "CHEBI:55376" ] }, "reaction_10622909": { "compartment": "compartment_1222282", "id": "reaction_10622909", "reactome": "R-DDI-8933635", "name": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1222719", "species_1470067", "species_6789221" ], "products": [ "species_8933637", "species_1222475" ], "modifiers": [ [ "species_10612843", "catalyst" ] ], "additional_components": [ "Q6TMK4", "DDB_G0277275", "CHEBI:55376" ] }, "reaction_10619501": { "compartment": "compartment_984", "id": "reaction_10619501", "reactome": "R-DDI-8855490", "name": "Lactoperoxidase (LPO) produces OSCN-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351629", "species_8855492" ], "products": [ "species_109276", "species_8855489" ], "modifiers": [ [ "species_10619498", "catalyst" ] ], "additional_components": [ "Q6TMK4", "DDB_G0277275", "CHEBI:55376" ] }, "reaction_10597227": { "compartment": "compartment_1222693", "id": "reaction_10597227", "reactome": "R-DDI-1222516", "name": "Intraphagosomal pH is lowered to 5 by V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106" ], "products": [ "species_1470067" ], "modifiers": [ [ "species_10597224", "catalyst" ] ], "additional_components": [ "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q55AH5", "DDB_G0271882", "Q86A77", "DDB_G0274331", "O00780", "DDB_G0275701", "Q54Z13", "DDB_G0277971", "Q76NU1", "DDB_G0277401", "P54648", "DDB_G0284473", "Q54E04", "DDB_G0291858", "Q86AS7", "DDB_G0274141", "P54642", "DDB_G0274381", "P54641", "DDB_G0273071" ] }, "reaction_10593221": { "compartment": "compartment_70101", "id": "reaction_10593221", "reactome": "R-DDI-450400", "name": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593206", "species_450597", "species_10593217" ], "products": [ "species_10593219" ], "modifiers": [], "additional_components": [ "DDB_G0269948", "DDB_G0285973", "Q54MG5", "DDB_G0285973", "Q55CQ7", "DDB_G0269948" ] }, "reaction_10593230": { "compartment": "compartment_70101", "id": "reaction_10593230", "reactome": "R-DDI-450431", "name": "ZFP36 (TTP) recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10593226", "species_10591881", "species_10591977", "species_10591874", "species_10593219" ], "products": [ "species_10593228" ], "modifiers": [], "additional_components": [ "DDB_G0289921", "DDB_G0283315", "Q55BJ2", "DDB_G0271100", "Q54VM4", "DDB_G0280251", "Q54CU6", "DDB_G0292692", "Q55BB0", "DDB_G0271396", "Q54EU6", "DDB_G0291328", "Q54Q83", "DDB_G0284053", "Q54EV5", "DDB_G0291310", "Q54N99", "DDB_G0285377", "Q54BH9", "DDB_G0293614", "Q7KWX9", "DDB_G0276783", "DDB_G0287243", "Q54MG5", "DDB_G0285973", "Q55CQ7", "DDB_G0269948", "Q54MG5", "DDB_G0285973", "Q55CQ7", "DDB_G0269948", "Q54KM1", "DDB_G0287243", "Q55BJ2", "DDB_G0271100", "Q54VM4", "DDB_G0280251", "Q54CU6", "DDB_G0292692", "Q55BB0", "DDB_G0271396", "Q54EU6", "DDB_G0291328", "Q54Q83", "DDB_G0284053", "Q54EV5", "DDB_G0291310", "Q54N99", "DDB_G0285377", "Q54BH9", "DDB_G0293614", "Q7KWX9", "DDB_G0276783", "Q54R87", "DDB_G0283315", "Q54GU2", "DDB_G0289921" ] }, "reaction_10602772": { "compartment": "compartment_70101", "id": "reaction_10602772", "reactome": "R-DDI-3371435", "name": "Constitutive phosphorylation by GSK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10602761" ], "products": [ "species_10602764", "species_29370" ], "modifiers": [ [ "species_10602769", "catalyst" ] ], "additional_components": [ "DDB_G0281165", "DDB_G0281165", "DDB_G0272110" ] }, "reaction_10602840": { "compartment": "compartment_7660", "id": "reaction_10602840", "reactome": "R-DDI-3371567", "name": "DBC1 is phosphorylated by ATM/ART", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10602832" ], "products": [ "species_113582", "species_10602826" ], "modifiers": [ [ "species_10602837", "catalyst" ] ], "additional_components": [ "DDB_G0274577", "DDB_G0274577", "DDB_G0291380" ] }, "reaction_10602830": { "compartment": "compartment_7660", "id": "reaction_10602830", "reactome": "R-DDI-3371537", "name": "DBC1 binds SIRT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602826", "species_10591478" ], "products": [ "species_10602828" ], "modifiers": [], "additional_components": [ "DDB_G0274577", "DDB_G0289967", "Q54GV7", "DDB_G0289967", "Q86A78", "DDB_G0274577" ] }, "reaction_10602865": { "compartment": "compartment_70101", "id": "reaction_10602865", "reactome": "R-DDI-3371591", "name": "Trimerization of cytosolic HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602761" ], "products": [ "species_10602814" ], "modifiers": [ [ "species_10583736", "catalyst" ] ], "additional_components": [ "DDB_G0281165", "Q54UC1", "DDB_G0281165", "P0CT31", "DDB_G0269134", "P0CT32", "DDB_G0269136" ] }, "reaction_10605045": { "compartment": "compartment_70101", "id": "reaction_10605045", "reactome": "R-DDI-5324632", "name": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5324631", "species_10605040" ], "products": [ "species_10602761", "species_10589012", "species_10605042", "species_10602802" ], "modifiers": [ [ "species_10605040", "catalyst" ] ], "additional_components": [ "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "Q54UC1", "DDB_G0281165", "Q54X15", "DDB_G0279267", "P90532", "DDB_G0288065", "DDB_G0281165", "DDB_G0268042", "Q54X15", "DDB_G0279267", "P90532", "DDB_G0288065", "P54651", "DDB_G0267400", "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "Q54UC1", "DDB_G0281165", "Q54X15", "DDB_G0279267", "P90532", "DDB_G0288065" ] }, "reaction_10602820": { "compartment": "compartment_70101", "id": "reaction_10602820", "reactome": "R-DDI-3371527", "name": "HSF1 trimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602814" ], "products": [ "species_10602818" ], "modifiers": [], "additional_components": [ "Q54UC1", "DDB_G0281165", "Q54UC1", "DDB_G0281165" ] }, "reaction_10602857": { "compartment": "compartment_70101", "id": "reaction_10602857", "reactome": "R-DDI-3371586", "name": "Dissociation of cytosolic HSF1:HSP90 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10602855" ], "products": [ "species_10602761", "species_10589012", "species_10602802" ], "modifiers": [], "additional_components": [ "P54651", "DDB_G0267400", "Q55FM3", "DDB_G0268042", "Q54UC1", "DDB_G0281165", "DDB_G0281165", "DDB_G0268042", "P54651", "DDB_G0267400" ] }, "reaction_10604376": { "compartment": "compartment_7660", "id": "reaction_10604376", "reactome": "R-DDI-5082409", "name": "Dissociation of HSF1:HSP90 complex in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604374" ], "products": [ "species_10604366", "species_10604347", "species_10604372" ], "modifiers": [], "additional_components": [ "P54651", "DDB_G0267400", "Q54UC1", "DDB_G0281165", "Q55FM3", "DDB_G0268042", "DDB_G0268042", "DDB_G0281165", "P54651", "DDB_G0267400" ] }, "reaction_10604349": { "compartment": "compartment_7660", "id": "reaction_10604349", "reactome": "R-DDI-5082391", "name": "Trimerization of HSF1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10604347" ], "products": [ "species_10602818" ], "modifiers": [], "additional_components": [ "DDB_G0281165", "Q54UC1", "DDB_G0281165" ] }, "reaction_10582483": { "compartment": "compartment_7660", "id": "reaction_10582483", "reactome": "R-DDI-77590", "name": "Recruitment of CstF to the CPSF Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10582477", "species_10579555" ], "products": [ "species_10582481" ], "modifiers": [], "additional_components": [ "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q55BS1", "DDB_G0270392", "Q55CA3", "DDB_G0270148", "Q54PX4", "DDB_G0284319", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797", "C7G084", "DDB_G0295793", "Q54TS6", "DDB_G0281585", "Q54V94", "DDB_G0280529", "Q54XS9", "DDB_G0278769", "Q54LG7", "DDB_G0286645", "Q54V94", "DDB_G0280529", "Q54XS9", "DDB_G0278769", "Q54LG7", "DDB_G0286645", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q55BS1", "DDB_G0270392", "Q55CA3", "DDB_G0270148", "Q54PX4", "DDB_G0284319", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797", "C7G084", "DDB_G0295793", "Q54TS6", "DDB_G0281585" ] }, "reaction_10582479": { "compartment": "compartment_7660", "id": "reaction_10582479", "reactome": "R-DDI-77589", "name": "Recognition of AAUAAA sequence by CPSF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10579534", "species_10582475" ], "products": [ "species_10582477" ], "modifiers": [], "additional_components": [ "Q55BS1", "DDB_G0270392", "Q55CA3", "DDB_G0270148", "Q54PX4", "DDB_G0284319", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797", "C7G084", "DDB_G0295793", "Q54TS6", "DDB_G0281585", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q55D17", "DDB_G0269814", "Q54KR9", "DDB_G0287197", "Q55BS1", "DDB_G0270392", "Q55CA3", "DDB_G0270148", "Q54PX4", "DDB_G0284319", "Q86A79", "DDB_G0274799", "Q54IF1", "DDB_G0288797", "C7G084", "DDB_G0295793", "Q54TS6", "DDB_G0281585" ] }, "reaction_10601473": { "compartment": "compartment_70101", "id": "reaction_10601473", "reactome": "R-DDI-2586748", "name": "GUCA binds Ca2+ to form GUCA:Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10581368", "species_74016" ], "products": [ "species_10581380" ], "modifiers": [], "additional_components": [ "DDB_G0275931", "species_74112", "Q75K28", "DDB_G0275931" ] }, "reaction_10601385": { "compartment": "compartment_70101", "id": "reaction_10601385", "reactome": "R-DDI-2534087", "name": "NMT1/2 transfer MYS to GNAT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601375", "species_2534019" ], "products": [ "species_10581129", "species_76194" ], "modifiers": [ [ "species_10601380", "catalyst" ] ], "additional_components": [ "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "Q54VG1", "DDB_G0280351", "P16051", "DDB_G0276267", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "DDB_G0275863" ] }, "reaction_10601432": { "compartment": "compartment_70101", "id": "reaction_10601432", "reactome": "R-DDI-2534096", "name": "METAP1/2 demethylates GNAT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10601413" ], "products": [ "species_10601375", "species_174390" ], "modifiers": [ [ "species_10601429", "catalyst" ] ], "additional_components": [ "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "P16051", "DDB_G0276267", "P16894", "DDB_G0283349", "P34042", "DDB_G0285425", "P34043", "DDB_G0286185", "P34044", "DDB_G0283151", "P34045", "DDB_G0276455", "P34046", "DDB_G0284469", "Q54KV6", "DDB_G0287031", "Q54R41", "DDB_G0283419", "Q54UG5", "DDB_G0280965", "Q54VG1", "DDB_G0280351", "Q55EP5", "DDB_G0268802", "Q8T130", "DDB_G0276343", "Q55C21", "DDB_G0270264", "species_880069", "Q54WU3", "DDB_G0279433" ] }, "reaction_10581390": { "compartment": "compartment_2514888", "id": "reaction_10581390", "reactome": "R-DDI-74885", "name": "GUCYs converts GTP to cGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438" ], "products": [ "species_111294", "species_30991" ], "modifiers": [ [ "species_10581362", "catalyst" ], [ "species_10581382", "catalyst" ], [ "species_10581384", "catalyst" ], [ "species_10581380", "inhibitor" ], [ "species_10581386", "inhibitor" ], [ "species_10581388", "inhibitor" ] ], "additional_components": [ "Q03101", "DDB_G0274569", "Q553Y7", "DDB_G0275009", "DDB_G0275931", "DDB_G0275931", "species_74112", "Q75K28", "DDB_G0275931", "species_74112", "Q75K28", "DDB_G0275931", "species_74112", "Q75K28", "DDB_G0275931" ] }, "reaction_10591906": { "compartment": "compartment_70101", "id": "reaction_10591906", "reactome": "R-DDI-429978", "name": "Lsm1-7 Complex binds deadenylated mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10591863", "species_429974" ], "products": [ "species_10591865" ], "modifiers": [], "additional_components": [ "Q54HF6", "DDB_G0289499", "Q55F60", "DDB_G0268244", "Q54W83", "DDB_G0279837", "Q1ZXK3", "DDB_G0277107", "Q54KX4", "DDB_G0287053", "Q55EX5", "DDB_G0268716", "Q552U1", "DDB_G0275719", "Q54TF6", "DDB_G0281779", "Q54HF6", "DDB_G0289499", "Q55F60", "DDB_G0268244", "Q54W83", "DDB_G0279837", "Q1ZXK3", "DDB_G0277107", "Q54KX4", "DDB_G0287053", "Q55EX5", "DDB_G0268716", "Q552U1", "DDB_G0275719", "Q54TF6", "DDB_G0281779" ] }, "reaction_10591896": { "compartment": "compartment_70101", "id": "reaction_10591896", "reactome": "R-DDI-429860", "name": "DCP1-DCP2 complex decaps mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10591865" ], "products": [ "species_10591867", "species_430004" ], "modifiers": [ [ "species_10591893", "catalyst" ] ], "additional_components": [ "Q54HF6", "DDB_G0289499", "Q55F60", "DDB_G0268244", "Q54W83", "DDB_G0279837", "Q1ZXK3", "DDB_G0277107", "Q54KX4", "DDB_G0287053", "Q55EX5", "DDB_G0268716", "Q552U1", "DDB_G0275719", "Q54TF6", "DDB_G0281779", "Q54HF6", "DDB_G0289499", "Q55F60", "DDB_G0268244", "Q54W83", "DDB_G0279837", "Q1ZXK3", "DDB_G0277107", "Q54KX4", "DDB_G0287053", "Q55EX5", "DDB_G0268716", "Q552U1", "DDB_G0275719", "Q54TF6", "DDB_G0281779", "Q54E49", "DDB_G0291804", "Q54KM1", "DDB_G0287243", "Q54R87", "DDB_G0283315", "Q54J96", "DDB_G0288241" ] }, "reaction_10589052": { "compartment": "compartment_984", "id": "reaction_10589052", "reactome": "R-DDI-265456", "name": "NPC1L1 inactivation by ezetimibe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10589048", "species_265479" ], "products": [ "species_10589050" ], "modifiers": [], "additional_components": [ "Q551C5", "DDB_G0276657", "Q9TVK6", "DDB_G0269158", "species_265479", "Q551C5", "DDB_G0276657", "Q9TVK6", "DDB_G0269158" ] }, "reaction_10619411": { "compartment": "compartment_17938", "id": "reaction_10619411", "reactome": "R-DDI-8854329", "name": "TBC1D15 accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10619394" ], "products": [ "species_29372", "species_10619396" ], "modifiers": [ [ "species_10619394", "catalyst" ], [ "species_10619409", "catalyst" ] ], "additional_components": [ "species_29438", "P36411", "DDB_G0269236", "Q54FK4", "DDB_G0290833", "Q54FK2", "DDB_G0290793", "Q54FK7", "DDB_G0290779", "Q54FK5", "DDB_G0290789", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "Q54FK8", "DDB_G0290829", "Q1ZXB9", "DDB_G0290831", "Q1ZXB8", "DDB_G0294571", "Q552H0", "DDB_G0294571", "P36411", "DDB_G0269236", "Q54FK4", "DDB_G0290833", "Q54FK2", "DDB_G0290793", "Q54FK7", "DDB_G0290779", "Q54FK5", "DDB_G0290789", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "Q54FK8", "DDB_G0290829", "Q1ZXB9", "DDB_G0290831", "Q1ZXB8", "DDB_G0294571", "Q552H0", "DDB_G0294571", "species_29420", "species_29438", "P36411", "DDB_G0269236", "Q54FK4", "DDB_G0290833", "Q54FK2", "DDB_G0290793", "Q54FK7", "DDB_G0290779", "Q54FK5", "DDB_G0290789", "Q1ZXB7", "DDB_G0290791", "Q54K69", "DDB_G0287553", "Q54FK8", "DDB_G0290829", "Q1ZXB9", "DDB_G0290831", "Q1ZXB8", "DDB_G0294571", "Q552H0", "DDB_G0294571", "Q54IE1", "DDB_G0288811", "Q54UD8", "DDB_G0288811" ] }, "reaction_10619424": { "compartment": "compartment_5683628", "id": "reaction_10619424", "reactome": "R-DDI-8854588", "name": "TBC1D25 (OATL1) binds ATG8 homologues", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619420", "species_10619414" ], "products": [ "species_10619422" ], "modifiers": [], "additional_components": [ "Q54UD8", "DDB_G0288811", "Q54IE1", "DDB_G0288811", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q54G11", "DDB_G0290491", "Q86CR8", "DDB_G0286191", "Q54UD8", "DDB_G0288811", "Q54IE1", "DDB_G0288811" ] }, "reaction_10619313": { "compartment": "compartment_19363", "id": "reaction_10619313", "reactome": "R-DDI-8854209", "name": "TBC1D10A binds JFC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619309", "species_10619303" ], "products": [ "species_10619311" ], "modifiers": [], "additional_components": [ "Q54Z16", "DDB_G0289735", "Q54H32", "DDB_G0289735", "DDB_G0282977", "Q54RR0", "DDB_G0282977", "Q54Z16", "DDB_G0289735", "Q54H32", "DDB_G0289735" ] }, "reaction_10619441": { "compartment": "compartment_437051", "id": "reaction_10619441", "reactome": "R-DDI-8854604", "name": "TBC1D16 accelerates GTP hydrolysis by RAB4A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10619430" ], "products": [ "species_29372", "species_10619432" ], "modifiers": [ [ "species_10619430", "catalyst" ], [ "species_10619439", "catalyst" ] ], "additional_components": [ "Q54DA7", "DDB_G0292406", "species_29438", "Q54DA7", "DDB_G0292406", "species_29420", "Q54DA7", "DDB_G0292406", "species_29438", "Q54IE1", "DDB_G0288811", "Q54UD8", "DDB_G0288811" ] }, "reaction_10619366": { "compartment": "compartment_20699", "id": "reaction_10619366", "reactome": "R-DDI-8854303", "name": "TBC1D11 binds RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10618515", "species_10619362" ], "products": [ "species_10619364" ], "modifiers": [], "additional_components": [ "Q55FK2", "DDB_G0268068", "species_29438", "DDB_G0290597", "Q54FT8", "DDB_G0290597", "Q55FK2", "DDB_G0268068", "species_29438" ] }, "reaction_10619478": { "compartment": "compartment_262783", "id": "reaction_10619478", "reactome": "R-DDI-8854759", "name": "TBC1D14 binds RAB11 and ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619469", "species_10619467", "species_10619474" ], "products": [ "species_10619476" ], "modifiers": [], "additional_components": [ "DDB_G0292390", "P36412", "DDB_G0269238", "Q86JP0", "DDB_G0294583", "DDB_G0269130", "O96904", "DDB_G0269130", "P36412", "DDB_G0269238", "Q86JP0", "DDB_G0294583", "Q86CS2", "DDB_G0292390" ] }, "reaction_10619300": { "compartment": "compartment_24339", "id": "reaction_10619300", "reactome": "R-DDI-8854173", "name": "TBC RabGAPs accelerate GTP hydrolysis by RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10619265" ], "products": [ "species_29372", "species_10619267" ], "modifiers": [ [ "species_10619265", "catalyst" ], [ "species_10619298", "catalyst" ] ], "additional_components": [ "Q54FL2", "DDB_G0290783", "species_29438", "species_29420", "Q54FL2", "DDB_G0290783", "Q54FL2", "DDB_G0290783", "species_29438", "Q54Z16", "DDB_G0289735", "Q54H32", "DDB_G0289735", "Q54CG7", "DDB_G0292932", "Q55F14", "DDB_G0269052" ] }, "reaction_10619352": { "compartment": "compartment_262783", "id": "reaction_10619352", "reactome": "R-DDI-8854293", "name": "TBC1D10A (EPI64) binds ARF6:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10619309", "species_10619348" ], "products": [ "species_10619350" ], "modifiers": [], "additional_components": [ "Q54Z16", "DDB_G0289735", "Q54H32", "DDB_G0289735", "Q554Y8", "DDB_G0274445", "species_29438", "Q554Y8", "DDB_G0274445", "species_29438", "Q54Z16", "DDB_G0289735", "Q54H32", "DDB_G0289735" ] }, "reaction_10619340": { "compartment": "compartment_17938", "id": "reaction_10619340", "reactome": "R-DDI-8854255", "name": "TBC1D2A accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10619323" ], "products": [ "species_10619325", "species_29372" ], "modifiers": [ [ "species_10619323", "catalyst" ], [ "species_10619338", "catalyst" ] ], "additional_components": [ "species_29438", "P36411", "DDB_G0269236", "P36411", "DDB_G0269236", "species_29420", "species_29438", "P36411", "DDB_G0269236", "Q553Q2", "DDB_G0295717", "C7G032", "DDB_G0295717", "Q55E78", "DDB_G0295717", "Q553U1", "DDB_G0295717", "Q75JG4", "DDB_G0276119" ] }, "reaction_10619453": { "compartment": "compartment_5683628", "id": "reaction_10619453", "reactome": "R-DDI-8854612", "name": "TBC1D25 accelerates GTP hydrolysis by RAB33B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10619448" ], "products": [ "species_29372", "species_10619450" ], "modifiers": [ [ "species_10619448", "catalyst" ], [ "species_10619420", "catalyst" ] ], "additional_components": [ "O76173", "DDB_G0269174", "species_29438", "O76173", "DDB_G0269174", "species_29420", "O76173", "DDB_G0269174", "species_29438", "Q54UD8", "DDB_G0288811", "Q54IE1", "DDB_G0288811" ] }, "reaction_10594836": { "compartment": "compartment_70101", "id": "reaction_10594836", "reactome": "R-DDI-917696", "name": "Cargo Sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594815", "species_10594832" ], "products": [ "species_10594813", "species_10594834" ], "modifiers": [], "additional_components": [ "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P14797", "DDB_G0276765", "species_179838", "Q55DV8", "DDB_G0269510", "Q54NF1", "DDB_G0285295", "Q54LJ3", "DDB_G0286797", "Q54RC4", "DDB_G0283203", "Q55GD9", "DDB_G0267708", "Q54T18", "DDB_G0282045", "Q55DV8", "DDB_G0269510", "Q54NF1", "DDB_G0285295", "Q54LJ3", "DDB_G0286797", "Q54RC4", "DDB_G0283203", "Q55GD9", "DDB_G0267708", "Q54T18", "DDB_G0282045", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P14797", "DDB_G0276765", "species_179838" ] }, "reaction_10594788": { "compartment": "compartment_74700", "id": "reaction_10594788", "reactome": "R-DDI-917693", "name": "ESCRT Disassembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10594631" ], "products": [ "species_29372", "species_10594475", "species_29370", "species_10594489", "species_10594470", "species_10594484", "species_10594769", "species_10594465" ], "modifiers": [ [ "species_10594785", "catalyst" ] ], "additional_components": [ "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P14797", "DDB_G0276765", "species_179838", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54P63", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q86H98", "DDB_G0275573", "DDB_G0275573", "DDB_G0287993", "DDB_G0284769", "DDB_G0287021", "species_179838", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0290087", "Q54PT2", "DDB_G0284347", "Q54JK4", "DDB_G0287993", "Q55B11", "DDB_G0271488" ] }, "reaction_10594838": { "compartment": "compartment_70101", "id": "reaction_10594838", "reactome": "R-DDI-917700", "name": "MVB Vesicle Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10594491", "species_10594834" ], "products": [ "species_10594631", "species_10594832" ], "modifiers": [], "additional_components": [ "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54P63", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q86H98", "DDB_G0275573", "Q54RC4", "DDB_G0283203", "Q55GD9", "DDB_G0267708", "Q54T18", "DDB_G0282045", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P14797", "DDB_G0276765", "species_179838", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P0CG78", "DDB_G0289449", "P0CG76", "DDB_G0282295", "P0CG79", "DDB_G0282369", "P14797", "DDB_G0276765", "species_179838", "Q54GK9", "DDB_G0290087", "Q54KZ4", "DDB_G0287021", "Q54P63", "DDB_G0284769", "Q54JK4", "DDB_G0287993", "Q86H98", "DDB_G0275573", "Q54RC4", "DDB_G0283203", "Q55GD9", "DDB_G0267708", "Q54T18", "DDB_G0282045" ] }, "reaction_10611220": { "compartment": "compartment_70101", "id": "reaction_10611220", "reactome": "R-DDI-5691131", "name": "CANDI binds CUL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10585421", "species_10611216" ], "products": [ "species_10611218" ], "modifiers": [], "additional_components": [ "DDB_G0291972", "DDB_G0274167", "Q86KD1", "DDB_G0274167", "O60999", "DDB_G0291972" ] }, "reaction_10611211": { "compartment": "compartment_70101", "id": "reaction_10611211", "reactome": "R-DDI-5691108", "name": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10611084", "species_10577037" ], "products": [ "species_10611202" ], "modifiers": [ [ "species_10611208", "catalyst" ] ], "additional_components": [ "DDB_G0279159", "P0CG76", "DDB_G0282295", "P0CG78", "DDB_G0289449", "P0CG79", "DDB_G0282369", "P0CG80", "DDB_G0291928", "P0CG81", "DDB_G0279721", "P0CG88", "DDB_G0269458", "P14797", "DDB_G0276765", "DDB_G0279159", "P52285", "DDB_G0269230", "Q557E4", "DDB_G0273251", "O60999", "DDB_G0291972", "Q54XV3", "DDB_G0278711" ] }, "reaction_10611082": { "compartment": "compartment_70101", "id": "reaction_10611082", "reactome": "R-DDI-5690873", "name": "ACO1 binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690881", "species_10611078" ], "products": [ "species_10611080" ], "modifiers": [], "additional_components": [ "DDB_G0279159", "Q54X73", "DDB_G0279159" ] }, "reaction_10594848": { "compartment": "compartment_74700", "id": "reaction_10594848", "reactome": "R-DDI-917936", "name": "MCOLN1 transports Fe2+ from endosome lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_917810" ], "products": [ "species_71067" ], "modifiers": [ [ "species_10594845", "catalyst" ] ], "additional_components": [ "DDB_G0291275" ] }, "reaction_10594840": { "compartment": "compartment_74700", "id": "reaction_10594840", "reactome": "R-DDI-917841", "name": "Acidification of Tf:TfR1 containing endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_70106", "species_113592" ], "products": [ "species_29372", "species_29370", "species_74722" ], "modifiers": [ [ "species_10581339", "catalyst" ] ], "additional_components": [ "P54647", "DDB_G0287127", "Q8MML6", "DDB_G0274553", "Q55AH5", "DDB_G0271882", "Q86A77", "DDB_G0274331", "O00780", "DDB_G0275701", "Q54Z13", "DDB_G0277971", "Q76NU1", "DDB_G0277401", "P54648", "DDB_G0284473", "P54641", "DDB_G0273071", "Q86AS7", "DDB_G0274141", "Q54E04", "DDB_G0291858", "P54642", "DDB_G0274381", "Q557I5", "DDB_G0273483" ] }, "reaction_10611087": { "compartment": "compartment_70101", "id": "reaction_10611087", "reactome": "R-DDI-5690911", "name": "ACO1:4Fe-4S isomerises CIT to ISCIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76190" ], "products": [ "species_389545" ], "modifiers": [ [ "species_10611080", "catalyst" ] ], "additional_components": [ "Q54X73", "DDB_G0279159" ] } }, "mod_collapsed_pathways": {}, "degree_dictionary": { "reaction_10584068": 1, "species_10581670": 6, "Q869X2": 4, "DDB_G0275077": 1, "Q55E72": 4, "DDB_G0269364": 1, "Q869W9": 4, "DDB_G0275069": 1, "reaction_10584072": 1, "species_10584070": 2, "DDB_G0288387": 3, "reaction_10584074": 1, "species_10581684": 2, "DDB_G0291332": 2, "reaction_10601278": 3, "species_10600215": 4, "Q54IA3": 6, "DDB_G0295485": 2, "B0G154": 6, "species_10601195": 3, "species_10601275": 8, "Q54TR1": 11, "DDB_G0281605": 1, "Q54UH2": 11, "DDB_G0282991": 4, "Q54UH3": 11, "Q86KD4": 11, "P04989": 11, "DDB_G0279799": 1, "Q23894": 11, "DDB_G0283867": 1, "Q54RQ2": 11, "reaction_10603294": 4, "species_10598295": 4, "DDB_G0270488": 4, "species_10603257": 2, "species_10603255": 2, "species_10603291": 8, "reaction_10594336": 2, "species_10594322": 5, "O00910": 48, "DDB_G0281381": 1, "Q54BD4": 48, "DDB_G0293532": 1, "Q70GP4": 48, "DDB_G0268638": 1, "Q86I20": 48, "DDB_G0275167": 1, "species_10594334": 5, "reaction_10597154": 6, "species_10595036": 3, "DDB_G0270272": 4, "species_113592": 309, "species_10595029": 3, "DDB_G0292984": 2, "species_111294": 51, "species_10597151": 4, "Q54CI1": 11, "Q55C16": 10, "species_76577": 60, "reaction_10597170": 4, "species_10595031": 4, "DDB_G0281833": 3, "species_10597143": 4, "Q54TE1": 43, "reaction_10597158": 3, "species_10596135": 3, "C7G034": 12, "DDB_G0285063": 1, "Q54QF1": 8, "DDB_G0283983": 1, "species_10597156": 4, "reaction_10599224": 4, "species_10599208": 13, "B0G0Z1": 4, "DDB_G0284841": 4, "Q54E38": 6, "DDB_G0291820": 1, "Q55BQ5": 4, "Q54P37": 4, "Q54T63": 4, "Q54D12": 11, "DDB_G0292586": 3, "Q54NH2": 11, "Q54Q67": 11, "Q54I29": 12, "DDB_G0289043": 4, "species_10599220": 6, "Q55FE0": 15, "DDB_G0268574": 2, 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